| Year |
Citation |
Score |
| 2021 |
Gomez-Escribano JP, Algora Gallardo L, Bozhüyük KAJ, Kendrew SG, Huckle BD, Crowhurst NA, Bibb MJ, Collis AJ, Micklefield J, Herron PR, Wilkinson B. Genome editing reveals that pSCL4 is required for chromosome linearity in . Microbial Genomics. 7. PMID 34747689 DOI: 10.1099/mgen.0.000669 |
0.687 |
|
| 2020 |
Dunstan MS, Robinson CJ, Jervis AJ, Yan C, Carbonell P, Hollywood KA, Currin A, Swainston N, Feuvre RL, Micklefield J, Faulon JL, Breitling R, Turner N, Takano E, Scrutton NS. Engineering towards production of gatekeeper (2)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol. Synthetic Biology (Oxford, England). 5: ysaa012. PMID 33195815 DOI: 10.1093/Synbio/Ysaa012 |
0.318 |
|
| 2020 |
Herbert AJ, Shepherd SA, Cronin VA, Bennett MR, Sung R, Micklefield J. Engineering orthogonal methyltransferases to create alternative bioalkylation pathways. Angewandte Chemie (International Ed. in English). PMID 32402113 DOI: 10.1002/Anie.202004963 |
0.372 |
|
| 2020 |
Robinson CJ, Carbonell P, Jervis AJ, Yan C, Hollywood KA, Dunstan MS, Currin A, Swainston N, Spiess R, Taylor S, Mulherin P, Parker S, Rowe W, Matthews NE, Malone KJ, ... ... Micklefield J, et al. Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers. Metabolic Engineering. PMID 32335188 DOI: 10.1016/J.Ymben.2020.04.008 |
0.336 |
|
| 2020 |
Winn M, Richardson SM, Campopiano DJ, Micklefield J. Harnessing and engineering amide bond forming ligases for the synthesis of amides. Current Opinion in Chemical Biology. 55: 77-85. PMID 32058241 DOI: 10.1016/J.Cbpa.2019.12.004 |
0.364 |
|
| 2019 |
Bozhüyük KA, Micklefield J, Wilkinson B. Engineering enzymatic assembly lines to produce new antibiotics. Current Opinion in Microbiology. 51: 88-96. PMID 31743841 DOI: 10.1016/J.Mib.2019.10.007 |
0.728 |
|
| 2019 |
Cummings M, Peters AD, Whitehead GFS, Menon BRK, Micklefield J, Webb SJ, Takano E. Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli. Plos Biology. 17: e3000347. PMID 31318855 DOI: 10.1371/Journal.Pbio.3000347 |
0.349 |
|
| 2018 |
Bennett M, Thompson M, Shepherd S, Dunstan M, Herbert A, Smith D, Cronin V, Menon B, Levy C, Micklefield J. Structure and Biocatalytic Scope of Coclaurine N-Methyltransferase. Angewandte Chemie (International Ed. in English). PMID 29791083 DOI: 10.1002/Anie.201805060 |
0.348 |
|
| 2018 |
de Mattos-Shipley KMJ, Greco C, Heard DM, Hough G, Mulholland NP, Vincent JL, Micklefield J, Simpson TJ, Willis CL, Cox RJ, Bailey AM. The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis. Chemical Science. 9: 4109-4117. PMID 29780540 DOI: 10.1039/C8Sc00717A |
0.419 |
|
| 2018 |
Winn M, Francis D, Micklefield J. De novo Biosynthesis of 'Non-Natural' Thaxtomin Phytotoxins. Angewandte Chemie (International Ed. in English). PMID 29603527 DOI: 10.1002/Anie.201801525 |
0.387 |
|
| 2017 |
Fisk H, Xu Y, Westley C, Turner NJ, Micklefield J, Goodacre R. From multi-step enzyme monitoring to whole-cell biotransformations: development of real-time UVRR spectroscopy. Analytical Chemistry. PMID 29076721 DOI: 10.1021/Acs.Analchem.7B03742 |
0.323 |
|
| 2017 |
Menon B, Brandenburger E, Sharif H, Klemstein U, Shepherd S, Greaney M, Micklefield J. RadH a Versatile Halogenase for Integration into Synthetic Pathways. Angewandte Chemie (International Ed. in English). PMID 28722773 DOI: 10.1002/Anie.201706342 |
0.405 |
|
| 2017 |
Latham J, Brandenburger E, Shepherd SA, Menon BRK, Micklefield J. Development of Halogenase Enzymes for Use in Synthesis. Chemical Reviews. PMID 28466644 DOI: 10.1021/Acs.Chemrev.7B00032 |
0.368 |
|
| 2017 |
Westley C, Fisk H, Xu Y, Hollywood K, Carnell A, Micklefield J, Turner N, Goodacre R. Real-time monitoring of enzyme-catalysed reactions using deep UV resonance Raman spectroscopy. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28370547 DOI: 10.1002/Chem.201701388 |
0.301 |
|
| 2017 |
Bennett MR, Shepherd SA, Cronin VA, Micklefield J. Recent advances in methyltransferase biocatalysis. Current Opinion in Chemical Biology. 37: 97-106. PMID 28259085 DOI: 10.1016/J.Cbpa.2017.01.020 |
0.365 |
|
| 2016 |
Menon BR, Latham J, Dunstan MS, Brandenburger E, Klemstein U, Leys D, Karthikeyan C, Greaney MF, Shepherd SA, Micklefield J. Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes. Organic & Biomolecular Chemistry. 14: 9354-9361. PMID 27714222 DOI: 10.1039/C6Ob01861K |
0.343 |
|
| 2016 |
Robinson CJ, Medina-Stacey D, Wu MC, Vincent HA, Micklefield J. Rewiring Riboswitches to Create New Genetic Circuits in Bacteria. Methods in Enzymology. 575: 319-48. PMID 27417935 DOI: 10.1016/Bs.Mie.2016.02.022 |
0.357 |
|
| 2016 |
Carbonell P, Currin A, Dunstan M, Fellows D, Jervis A, Rattray NJ, Robinson CJ, Swainston N, Vinaixa M, Williams A, Yan C, Barran P, Breitling R, Chen GG, Faulon JL, ... ... Micklefield J, et al. SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals. Biochemical Society Transactions. 44: 675-7. PMID 27284023 DOI: 10.1042/Bst20160009 |
0.332 |
|
| 2016 |
Struck AW, Bennett MR, Shepherd SA, Law BJ, Zhou Y, Wong LS, Micklefield J. An Enzyme Cascade for Selective Modification of Tyrosine Residues in Structurally Diverse Peptides and Proteins. Journal of the American Chemical Society. PMID 26867114 DOI: 10.1021/Jacs.5B10928 |
0.364 |
|
| 2016 |
Shepherd SA, Menon BR, Fisk H, Struck AW, Levy C, Leys D, Micklefield J. A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase Enzyme. Chembiochem : a European Journal of Chemical Biology. PMID 26840773 DOI: 10.1002/Cbic.201600051 |
0.337 |
|
| 2016 |
Law BJ, Bennett MR, Thompson ML, Levy C, Shepherd SA, Leys D, Micklefield J. Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase. Angewandte Chemie (International Ed. in English). PMID 26797714 DOI: 10.1002/Anie.201508287 |
0.316 |
|
| 2016 |
Winn M, Fyans JK, Zhuo Y, Micklefield J. Recent advances in engineering nonribosomal peptide assembly lines Natural Product Reports. 33: 317-347. DOI: 10.1039/C5Np00099H |
0.373 |
|
| 2015 |
Shepherd SA, Karthikeyan C, Latham J, Struck AW, Thompson ML, Menon BRK, Styles MQ, Levy C, Leys D, Micklefield J. Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes. Chemical Science. 6: 3454-3460. PMID 29511510 DOI: 10.1039/C5Sc00913H |
0.378 |
|
| 2015 |
Law BJC, Struck AW, Bennett MR, Wilkinson B, Micklefield J. Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase. Chemical Science. 6: 2885-2892. PMID 29403635 DOI: 10.1039/C5Sc00164A |
0.732 |
|
| 2015 |
Morra R, Shankar J, Robinson CJ, Halliwell S, Butler L, Upton M, Hay S, Micklefield J, Dixon N. Dual transcriptional-translational cascade permits cellular level tuneable expression control. Nucleic Acids Research. PMID 26405200 DOI: 10.1093/Nar/Gkv912 |
0.554 |
|
| 2015 |
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Micklefield J, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890 |
0.715 |
|
| 2015 |
Wu MC, Lowe PT, Robinson CJ, Vincent HA, Dixon N, Leigh J, Micklefield J. Rational Re-engineering of a Transcriptional Silencing PreQ1 Riboswitch. Journal of the American Chemical Society. PMID 26106809 DOI: 10.1021/Jacs.5B03405 |
0.575 |
|
| 2015 |
Wu MC, Styles MQ, Law BJ, Struck AW, Nunns L, Micklefield J. Engineered Biosynthesis of Enduracidin Lipoglycopeptide Antibiotics using the Ramoplanin Mannosyltransferase Ram29. Microbiology (Reading, England). PMID 25878261 DOI: 10.1099/Mic.0.000095 |
0.427 |
|
| 2015 |
Lewin R, Goodall M, Thompson ML, Leigh J, Breuer M, Baldenius K, Micklefield J. Enzymatic enantioselective decarboxylative protonation of heteroaryl malonates. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 6557-63. PMID 25766433 DOI: 10.1002/Chem.201406014 |
0.375 |
|
| 2015 |
Diez V, Loznik M, Taylor S, Winn M, Rattray NJ, Podmore H, Micklefield J, Goodacre R, Medema MH, Müller U, Bovenberg R, Janssen DB, Takano E. Functional Exchangeability of Oxidase and Dehydrogenase Reactions in the Biosynthesis of Hydroxyphenylglycine, a Nonribosomal Peptide Building Block. Acs Synthetic Biology. 4: 796-807. PMID 25713978 DOI: 10.1021/Sb500368W |
0.393 |
|
| 2014 |
Robinson CJ, Vincent HA, Wu MC, Lowe PT, Dunstan MS, Leys D, Micklefield J. Modular riboswitch toolsets for synthetic genetic control in diverse bacterial species. Journal of the American Chemical Society. 136: 10615-24. PMID 24971878 DOI: 10.1021/Ja502873J |
0.364 |
|
| 2014 |
Vincent HA, Robinson CJ, Wu MC, Dixon N, Micklefield J. Generation of orthogonally selective bacterial riboswitches by targeted mutagenesis and in vivo screening. Methods in Molecular Biology (Clifton, N.J.). 1111: 107-29. PMID 24549615 DOI: 10.1007/978-1-62703-755-6_8 |
0.578 |
|
| 2012 |
Struck AW, Thompson ML, Wong LS, Micklefield J. S-adenosyl-methionine-dependent methyltransferases: highly versatile enzymes in biocatalysis, biosynthesis and other biotechnological applications. Chembiochem : a European Journal of Chemical Biology. 13: 2642-55. PMID 23180741 DOI: 10.1002/Cbic.201200556 |
0.364 |
|
| 2012 |
Thirlway J, Lewis R, Nunns L, Al Nakeeb M, Styles M, Struck AW, Smith CP, Micklefield J. Introduction of a non-natural amino acid into a nonribosomal peptide antibiotic by modification of adenylation domain specificity. Angewandte Chemie (International Ed. in English). 51: 7181-4. PMID 22711659 DOI: 10.1002/Anie.201202043 |
0.367 |
|
| 2012 |
Chen L, Cressina E, Dixon N, Erixon K, Agyei-Owusu K, Micklefield J, Smith AG, Abell C, Leeper FJ. Probing riboswitch-ligand interactions using thiamine pyrophosphate analogues. Organic & Biomolecular Chemistry. 10: 5924-31. PMID 22514012 DOI: 10.1039/C2Ob07116A |
0.532 |
|
| 2012 |
Wu MC, Law B, Wilkinson B, Micklefield J. Bioengineering natural product biosynthetic pathways for therapeutic applications. Current Opinion in Biotechnology. 23: 931-40. PMID 22487048 DOI: 10.1016/J.Copbio.2012.03.008 |
0.744 |
|
| 2012 |
Dixon N, Robinson CJ, Geerlings T, Duncan JN, Drummond SP, Micklefield J. Orthogonal riboswitches for tuneable coexpression in bacteria. Angewandte Chemie (International Ed. in English). 51: 3620-4. PMID 22383398 DOI: 10.1002/Anie.201109106 |
0.549 |
|
| 2011 |
Woolard J, Vousden W, Moss SJ, Krishnakumar A, Gammons MV, Nowak DG, Dixon N, Micklefield J, Spannhoff A, Bedford MT, Gregory MA, Martin CJ, Leadlay PF, Zhang MQ, Harper SJ, et al. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chemical Science (Royal Society of Chemistry : 2010). 2011: 273-278. PMID 22822423 DOI: 10.1039/C0Sc00297F |
0.732 |
|
| 2011 |
Worthington RJ, Micklefield J. Biophysical and cellular-uptake properties of mixed-sequence pyrrolidine-amide oligonucleotide mimics. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 14429-41. PMID 22076794 DOI: 10.1002/Chem.201101950 |
0.334 |
|
| 2011 |
Lewis RA, Nunns L, Thirlway J, Carroll K, Smith CP, Micklefield J. Active site modification of the β-ketoacyl-ACP synthase FabF3 of Streptomyces coelicolor affects the fatty acid chain length of the CDA lipopeptides. Chemical Communications (Cambridge, England). 47: 1860-2. PMID 21135931 DOI: 10.1039/C0Cc03444D |
0.355 |
|
| 2011 |
Dixon N, Robinson CJ, Duncan JN, Geerlings T, Lestari SA, Micklefield J. Orthogonal riboswitches as tools for controlling gene expression in bacteria Collection of Czechoslovak Chemical Communications. 12: 86-94. DOI: 10.1135/Css201112086 |
0.53 |
|
| 2010 |
Dixon N, Duncan JN, Geerlings T, Dunstan MS, McCarthy JE, Leys D, Micklefield J. Reengineering orthogonally selective riboswitches. Proceedings of the National Academy of Sciences of the United States of America. 107: 2830-5. PMID 20133756 DOI: 10.1073/Pnas.0911209107 |
0.56 |
|
| 2010 |
MICKLEFIELD J, BLOCK MH, BATTERSBY AR. ChemInform Abstract: Alkylation and Acylation of 5-Phenylsulfonyl- and 5-Cyanobutyrolactones. Cheminform. 24: no-no. DOI: 10.1002/chin.199301167 |
0.41 |
|
| 2009 |
Wong LS, Khan F, Micklefield J. Selective covalent protein immobilization: strategies and applications. Chemical Reviews. 109: 4025-53. PMID 19572643 DOI: 10.1021/Cr8004668 |
0.335 |
|
| 2009 |
Wilkinson B, Micklefield J. Chapter 14. Biosynthesis of nonribosomal peptide precursors. Methods in Enzymology. 458: 353-78. PMID 19374990 DOI: 10.1016/S0076-6879(09)04814-9 |
0.733 |
|
| 2009 |
Micklefield J. Biosynthesis and biosynthetic engineering of calcium-dependent lipopeptide antibiotics Pure and Applied Chemistry. 81: 1065-1074. DOI: 10.1351/Pac-Con-08-08-29 |
0.423 |
|
| 2008 |
Wong LS, Thirlway J, Micklefield J. Direct site-selective covalent protein immobilization catalyzed by a phosphopantetheinyl transferase. Journal of the American Chemical Society. 130: 12456-64. PMID 18722432 DOI: 10.1021/Ja8030278 |
0.307 |
|
| 2008 |
Amir-Heidari B, Thirlway J, Micklefield J. Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues. Organic & Biomolecular Chemistry. 6: 975-8. PMID 18327318 DOI: 10.1039/B718766C |
0.366 |
|
| 2007 |
Dixon N, Wong LS, Geerlings TH, Micklefield J. Cellular targets of natural products. Natural Product Reports. 24: 1288-310. PMID 18033580 DOI: 10.1039/B616808F |
0.577 |
|
| 2007 |
Powell A, Borg M, Amir-Heidari B, Neary JM, Thirlway J, Wilkinson B, Smith CP, Micklefield J. Engineered biosynthesis of nonribosomal lipopeptides with modified fatty acid side chains. Journal of the American Chemical Society. 129: 15182-91. PMID 18020333 DOI: 10.1021/Ja074331O |
0.741 |
|
| 2007 |
Mahlert C, Kopp F, Thirlway J, Micklefield J, Marahiel MA. Stereospecific enzymatic transformation of alpha-ketoglutarate to (2S,3R)-3-methyl glutamate during acidic lipopeptide biosynthesis. Journal of the American Chemical Society. 129: 12011-8. PMID 17784761 DOI: 10.1021/Ja074427I |
0.371 |
|
| 2007 |
Powell A, Al Nakeeb M, Wilkinson B, Micklefield J. Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues. Chemical Communications (Cambridge, England). 2683-5. PMID 17594019 DOI: 10.1039/B706224A |
0.71 |
|
| 2007 |
Wilkinson B, Micklefield J. Mining and engineering natural-product biosynthetic pathways. Nature Chemical Biology. 3: 379-86. PMID 17576425 DOI: 10.1038/Nchembio.2007.7 |
0.753 |
|
| 2007 |
Neary JM, Powell A, Gordon L, Milne C, Flett F, Wilkinson B, Smith CP, Micklefield J. An asparagine oxygenase (AsnO) and a 3-hydroxyasparaginyl phosphotransferase (HasP) are involved in the biosynthesis of calcium-dependent lipopeptide antibiotics. Microbiology (Reading, England). 153: 768-76. PMID 17322197 DOI: 10.1099/Mic.0.2006/002725-0 |
0.748 |
|
| 2007 |
Tan TH, Worthington RJ, Pritchard RG, Morral J, Micklefield J. Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA/RNA binding properties. Organic & Biomolecular Chemistry. 5: 239-48. PMID 17205167 DOI: 10.1039/B613384N |
0.341 |
|
| 2006 |
Milne C, Powell A, Jim J, Al Nakeeb M, Smith CP, Micklefield J. Biosynthesis of the (2S,3R)-3-methyl glutamate residue of nonribosomal lipopeptides. Journal of the American Chemical Society. 128: 11250-9. PMID 16925444 DOI: 10.1021/Ja062960C |
0.334 |
|
| 2005 |
Micklefield J. Nature's protection racket. Chemistry & Biology. 12: 611-3. PMID 15975504 DOI: 10.1016/J.Chembiol.2005.06.002 |
0.313 |
|
| 2004 |
Uguru GC, Milne C, Borg M, Flett F, Smith CP, Micklefield J. Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates. Journal of the American Chemical Society. 126: 5032-3. PMID 15099062 DOI: 10.1021/Ja048778Y |
0.308 |
|
| 2002 |
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J. Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor. Chemistry & Biology. 9: 1175-87. PMID 12445768 DOI: 10.1016/S1074-5521(02)00252-1 |
0.751 |
|
| 2001 |
Micklefield J. Backbone modification of nucleic acids: synthesis, structure and therapeutic applications. Current Medicinal Chemistry. 8: 1157-79. PMID 11472234 DOI: 10.2174/0929867013372391 |
0.341 |
|
| 1997 |
Micklefield J, Beckmann M, Mackman RL, Block MH, Leeper FJ, Battersby AR. Haem d1: Stereoselective synthesis of the macrocycle to establish its absolute configuration as 2R,7R Journal of the Chemical Society - Perkin Transactions 1. 2123-2138. DOI: 10.1039/A700655A |
0.483 |
|
| 1997 |
Mackman RL, Micklefield J, Block MH, Leeper FJ, Battersby AR. Haem d1: Development of a new coupling procedure leading to the synthesis of isobacteriochlorins Journal of the Chemical Society - Perkin Transactions 1. 2111-2122. DOI: 10.1039/A700654C |
0.516 |
|
| 1995 |
Micklefield J, Harris KJ, Gröger S, Mocek U, Hilbi H, Dimroth P, Floss HG. Stereochemical course of malonate decarboxylation in Malonomonas rubra Journal of the American Chemical Society. 117: 1153-1154. DOI: 10.1021/Ja00108A042 |
0.445 |
|
| 1993 |
Micklefield J, MacKman RL, Aucken CJ, Beckmann M, Block MH, Leeper FJ, Battersby AR. A novel stereoselective synthesis of the macrocycle of haem d1 that establishes its absolute configuration as 2R,7R Journal of the Chemical Society, Chemical Communications. 275-277. DOI: 10.1039/C39930000275 |
0.466 |
|
| 1992 |
Micklefield J, Block MH, Battersby AR. Alkylation and acylation of 5-phenylsulphonyl- and 5-cyanobutyrolactones Tetrahedron. 48: 7519-7526. DOI: 10.1016/S0040-4020(01)90365-5 |
0.485 |
|
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