| Year |
Citation |
Score |
| 2023 |
Qian Y, Birhanu BT, Yang J, Ding D, Janardhanan J, Mobashery S, Chang M. A Potent and Narrow-Spectrum Antibacterial against Infection. Journal of Medicinal Chemistry. PMID 37732641 DOI: 10.1021/acs.jmedchem.3c01249 |
0.476 |
|
| 2023 |
Janardhanan J, Kim C, Qian Y, Yang J, Meisel JE, Ding D, Speri E, Schroeder VA, Wolter WR, Oliver AG, Mobashery S, Chang M. A dual-action antibiotic that kills vegetative cells and inhibits spore germination. Proceedings of the National Academy of Sciences of the United States of America. 120: e2304110120. PMID 37155891 DOI: 10.1073/pnas.2304110120 |
0.442 |
|
| 2023 |
Kim C, Lee M, Birhanu BH, Hesek D, Chang M, Mobashery S. Synthesis of Muramyl-δ-Lactam in Spore Peptidoglycan of Clostridioides difficile. Chembiochem : a European Journal of Chemical Biology. e202300282. PMID 37072375 DOI: 10.1002/cbic.202300282 |
0.416 |
|
| 2022 |
Thakur V, Thakur VS, Aguila B, Slepak TI, Wang M, Song W, Konai M, Mobashery S, Chang M, Rana AB, Wang D, de Freitas JT, Humayun Gultekin S, Welford SM, Ivan ME, et al. Targeting extracellular matrix remodeling sensitizes glioblastoma to ionizing radiation. Neuro-Oncology Advances. 4: vdac147. PMID 36212741 DOI: 10.1093/noajnl/vdac147 |
0.427 |
|
| 2022 |
Peng Z, Konai MM, Avila-Cobian LF, Wang M, Mobashery S, Chang M. MMP-1 and ADAM10 as Targets for Therapeutic Intervention in Idiopathic Pulmonary Fibrosis. Acs Pharmacology & Translational Science. 5: 548-554. PMID 35983283 DOI: 10.1021/acsptsci.2c00050 |
0.416 |
|
| 2022 |
Masitas C, Peng Z, Wang M, Konai MM, Avila-Cobian LF, Lemieux L, Hovanesian J, Grady JE, Mobashery S, Chang M. Matrix Metalloproteinase-14 as an Instigator of Fibrosis in Human Pterygium and Its Pharmacological Intervention. Acs Pharmacology & Translational Science. 5: 555-561. PMID 35983271 DOI: 10.1021/acsptsci.2c00125 |
0.436 |
|
| 2022 |
Peng Z, Nguyen TT, Wang M, Anderson B, Konai MM, Schroeder VA, Wolter WR, Page-Mayberry T, Peterson CE, Mobashery S, Chang M. Proteomics Identification of Targets for Intervention in Pressure Ulcers. Acs Chemical Biology. 17: 1357-1363. PMID 35670779 DOI: 10.1021/acschembio.2c00382 |
0.425 |
|
| 2021 |
Martínez-Caballero S, Mahasenan KV, Kim C, Molina R, Feltzer R, Lee M, Bouley R, Hesek D, Fisher JF, Muñoz IG, Chang M, Mobashery S, Hermoso JA. Integrative structural biology of the penicillin-binding protein-1 from , an essential component of the divisome machinery. Computational and Structural Biotechnology Journal. 19: 5392-5405. PMID 34667534 DOI: 10.1016/j.csbj.2021.09.018 |
0.448 |
|
| 2021 |
Kim C, Mahasenan KV, Bhardwaj A, Wiest O, Chang M, Mobashery S. Production of Proteins of the SARS-CoV-2 Proteome for Drug Discovery. Acs Omega. 6: 19983-19994. PMID 34337272 DOI: 10.1021/acsomega.1c02984 |
0.388 |
|
| 2021 |
Gabriel CER, Nguyen TT, Gargano EM, Fisher JF, Chang M, Mobashery S. Metabolism of the Selective Matrix Metalloproteinase-9 Inhibitor ()-ND-336. Acs Pharmacology & Translational Science. 4: 1204-1213. PMID 34151210 DOI: 10.1021/acsptsci.1c00063 |
0.402 |
|
| 2021 |
Speri E, Qian Y, Janardhanan J, Masitas C, Lastochkin E, De Benedetti S, Wang M, Schroeder VA, Wolter WR, Oliver AG, Fisher JF, Mobashery S, Chang M. Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target . Acs Medicinal Chemistry Letters. 12: 991-995. PMID 34141083 DOI: 10.1021/acsmedchemlett.1c00135 |
0.48 |
|
| 2021 |
Peng Z, Nguyen TT, Song W, Anderson B, Wolter WR, Schroeder VA, Hesek D, Lee M, Mobashery S, Chang M. Selective MMP-9 Inhibitor ()-ND-336 Alone or in Combination with Linezolid Accelerates Wound Healing in Infected Diabetic Mice. Acs Pharmacology & Translational Science. 4: 107-117. PMID 33615165 DOI: 10.1021/acsptsci.0c00104 |
0.454 |
|
| 2021 |
Chang M, Mahasenan KV, Hermoso JA, Mobashery S. Unconventional Antibacterials and Adjuvants. Accounts of Chemical Research. PMID 33512995 DOI: 10.1021/acs.accounts.0c00776 |
0.543 |
|
| 2020 |
Speri E, Janardhanan J, Masitas C, Schroeder VA, Lastochkin E, Wolter WR, Fisher J, Mobashery S, Chang M. Discovery of a potent picolinamide antibacterial active against . Acs Infectious Diseases. PMID 32786277 DOI: 10.1021/Acsinfecdis.0C00479 |
0.516 |
|
| 2020 |
Qian Y, Allegretta G, Janardhanan J, Peng Z, Mahasenan KV, Lastochkin E, Gozun MMN, Tejera S, Schroeder VA, Wolter WR, Feltzer R, Mobashery S, Chang M. Exploration of the Structural Space in 4()-Quinazolinone Antibacterials. Journal of Medicinal Chemistry. PMID 32343145 DOI: 10.1021/Acs.Jmedchem.0C00153 |
0.569 |
|
| 2020 |
Wang T, Hu Z, Du X, Shi Y, Dang J, Lee M, Hesek D, Mobashery S, Wu M, Liang H. A Type VI secretion system delivers a cell-wall amidase to target bacterial competitors. Molecular Microbiology. PMID 32279364 DOI: 10.1111/Mmi.14513 |
0.367 |
|
| 2020 |
Boudreau MA, Ding D, Meisel JE, Janardhanan J, Spink E, Peng Z, Qian Y, Yamaguchi T, Testero SA, O'Daniel PI, Leemans E, Lastochkin E, Song W, Schroeder VA, Wolter WR, ... ... Mobashery S, et al. Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. Acs Medicinal Chemistry Letters. 11: 322-326. PMID 32184964 DOI: 10.1021/Acsmedchemlett.9B00379 |
0.546 |
|
| 2020 |
Dik DA, Kim C, Madukoma CS, Fisher JF, Shrout JD, Mobashery S. Fluorescence Assessment of the AmpR-Signaling Network of Pseudomonas aeruginosa to Exposure to β-Lactam Antibiotics. Acs Chemical Biology. PMID 31990176 DOI: 10.1021/Acschembio.9B00875 |
0.38 |
|
| 2020 |
Min K, An DR, Yoon HJ, Rana N, Park JS, Kim J, Lee M, Hesek D, Ryu S, Kim BM, Mobashery S, Suh SW, Lee HH. Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni. Nature Communications. 11: 458. PMID 31974386 DOI: 10.1038/S41467-019-13934-4 |
0.335 |
|
| 2019 |
Mahasenan KV, Batuecas MT, De Benedetti S, Kim C, Rana N, Lee M, Hesek D, Fisher JF, Sanz-Aparicio J, Hermoso JA, Mobashery S. Catalytic Cycle of Glycoside Hydrolase BglX from Pseudomonas aeruginosa and Its Implication in Biofilm Formation. Acs Chemical Biology. PMID 31877028 DOI: 10.1021/Acschembio.9B00754 |
0.337 |
|
| 2019 |
Alcorlo M, Dik DA, De Benedetti S, Mahasenan KV, Lee M, Domínguez-Gil T, Hesek D, Lastochkin E, López D, Boggess B, Mobashery S, Hermoso JA. Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division. Nature Communications. 10: 5567. PMID 31804467 DOI: 10.1038/S41467-019-13354-4 |
0.308 |
|
| 2019 |
Fisher JF, Mobashery S. Constructing and deconstructing the bacterial cell wall. Protein Science : a Publication of the Protein Society. PMID 31747090 DOI: 10.1002/Pro.3737 |
0.435 |
|
| 2019 |
Nguyen TT, Jones JI, Wolter WR, Pérez RL, Schroeder VA, Champion MM, Hesek D, Lee M, Suckow MA, Mobashery S, Chang M. Hyperbaric Oxygen Therapy Accelerates Wound Healing in Diabetic Mice by Decreasing Active Matrix Metalloproteinase-9. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. PMID 31736209 DOI: 10.1111/Wrr.12782 |
0.493 |
|
| 2019 |
Ceballos S, Kim C, Qian Y, Mobashery S, Chang M, Torres C. Susceptibility of methicillin-resistant to five quinazolinone antibacterials. Antimicrobial Agents and Chemotherapy. PMID 31611358 DOI: 10.1128/Aac.01344-19 |
0.539 |
|
| 2019 |
Speri E, Kim C, De Benedetti S, Qian Y, Lastochkin E, Fishovitz J, Fisher JF, Mobashery S. Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-Resistant . Acs Medicinal Chemistry Letters. 10: 1148-1153. PMID 31413798 DOI: 10.1021/Acsmedchemlett.9B00169 |
0.396 |
|
| 2019 |
Janardhanan J, Bouley R, Martínez-Caballero S, Peng Z, Batuecas-Mordillo M, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mahasenan KV, Hermoso JA, Mobashery S, Chang M. The quinazolinone allosteric inhibitor of PBP2a synergizes with piperacillin and tazobactam against methicillin-resistant . Antimicrobial Agents and Chemotherapy. PMID 30858202 DOI: 10.1128/Aac.02637-18 |
0.595 |
|
| 2019 |
Dik DA, Madukoma CS, Tomoshige S, Kim C, Lastochkin E, Boggess WC, Fisher JF, Shrout JD, Mobashery S. Slt, MltD and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of -Lactam Antibiotics. Acs Chemical Biology. PMID 30620575 DOI: 10.1021/Acschembio.8B01025 |
0.608 |
|
| 2018 |
Speri E, Fishovitz J, Mobashery S. Structure-activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant (MRSA). Medchemcomm. 9: 2008-2016. PMID 30746061 DOI: 10.1039/C8Md00479J |
0.423 |
|
| 2018 |
Raz L, Yang Y, Thompson J, Hobson S, Pesko J, Mobashery S, Chang M, Rosenberg G. MMP-9 inhibitors impair learning in spontaneously hypertensive rats. Plos One. 13: e0208357. PMID 30533010 DOI: 10.1371/Journal.Pone.0208357 |
0.462 |
|
| 2018 |
Dik DA, Batuecas MT, Lee M, Mahasenan KV, Marous DR, Lastochkin E, Fisher JF, Hermoso JA, Mobashery S. A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli. Biochemistry. PMID 30256085 DOI: 10.1021/Acs.Biochem.8B00800 |
0.385 |
|
| 2018 |
Fisher JF, Mobashery S. A positive positive to negative. Nature Chemistry. 10: 998-1000. PMID 30237531 DOI: 10.1038/S41557-018-0148-Y |
0.321 |
|
| 2018 |
Nguyen TT, Ding D, Wolter WR, Perez RL, Champion MM, Mahasenan KV, Hesek D, Lee M, Schroeder VA, Jones JI, Lastochkin E, Rose MK, Peterson CE, Suckow MA, Mobashery S, et al. Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor that Accelerates Healing. Journal of Medicinal Chemistry. PMID 30212201 DOI: 10.1021/Acs.Jmedchem.8B01005 |
0.496 |
|
| 2018 |
Mahasenan KV, Ding D, Gao M, Nguyen TT, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S. In Search of Selectivity in Inhibition of ADAM10. Acs Medicinal Chemistry Letters. 9: 708-713. PMID 30034605 DOI: 10.1021/Acsmedchemlett.8B00163 |
0.49 |
|
| 2018 |
Nguyen TT, Ding D, Wolter WR, Champion MM, Hesek D, Lee M, Pérez RL, Schroeder VA, Suckow MA, Mobashery S, Chang M. Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers. European Journal of Pharmacology. PMID 30012502 DOI: 10.1016/J.Ejphar.2018.07.014 |
0.474 |
|
| 2018 |
Chen S, Chen Z, Cui J, McCrary ML, Song H, Mobashery S, Chang M, Gu Z. Early Abrogation of Gelatinase Activity Extends the Time Window for tPA Thrombolysis after Embolic Focal Cerebral Ischemia in Mice. Eneuro. 5. PMID 29963617 DOI: 10.1523/ENEURO.0391-17.2018 |
0.399 |
|
| 2018 |
Ceballos S, Kim C, Ding D, Mobashery S, Chang M, Torres C. Activities of oxadiazole antibacterials against and other Gram-positive bacteria. Antimicrobial Agents and Chemotherapy. PMID 29866865 DOI: 10.1128/Aac.00453-18 |
0.557 |
|
| 2018 |
Dik DA, Fisher JF, Mobashery S. Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance. Chemical Reviews. PMID 29847102 DOI: 10.1021/Acs.Chemrev.8B00277 |
0.417 |
|
| 2018 |
Tomoshige S, Dik DA, Akabane-Nakata M, Madukoma C, Fisher JF, Shrout JD, Mobashery S. Total Syntheses of Bulgecins A, B and C and Their Bactericidal Potentiation of the β-Lactam Antibiotics. Acs Infectious Diseases. PMID 29716193 DOI: 10.1021/Acsinfecdis.8B00105 |
0.394 |
|
| 2018 |
Byun B, Mahasenan KV, Dik DA, Marous DR, Speri E, Kumarasiri M, Fisher JF, Hermoso JA, Mobashery S. Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly. Scientific Reports. 8: 4110. PMID 29515200 DOI: 10.1038/S41598-018-22527-Y |
0.355 |
|
| 2018 |
Kim C, Hesek D, Lee M, Mobashery S. Potentiation of the activity of β-lactam antibiotics by farnesol and its derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 29402738 DOI: 10.1016/J.Bmcl.2018.01.028 |
0.416 |
|
| 2018 |
Bernardo-Garcia N, Mahasenan KV, Batuecas MT, Lee M, Hesek D, Petráčková D, Doubravová L, Branny P, Mobashery S, Hermoso JA. Allostery, Recognition of Nascent Peptidoglycan and Crosslinking of the Cell Wall by the Essential Penicillin-Binding Protein 2x of Streptococcus pneumoniae. Acs Chemical Biology. PMID 29357220 DOI: 10.1021/Acschembio.7B00817 |
0.394 |
|
| 2018 |
Lee M, Batuecas MT, Tomoshige S, Domínguez-Gil T, Mahasenan KV, Dik DA, Hesek D, Millán C, Usón I, Lastochkin E, Hermoso JA, Mobashery S. Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt ofPseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America. 115: 4393-4398. DOI: 10.2210/Pdb6Fbt/Pdb |
0.379 |
|
| 2017 |
Domínguez-Gil T, Molina R, Dik DA, Spink E, Mobashery S, Hermoso JA. The X-ray Structure of Catenated Lytic Transglycosylase SltB1. Biochemistry. PMID 29131935 DOI: 10.1021/Acs.Biochem.7B00932 |
0.331 |
|
| 2017 |
Testero SA, Granados C, Fernández D, Gallego P, Covaleda G, Reverter D, Vendrell J, Avilés FX, Pallarès I, Mobashery S. Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library. Acs Medicinal Chemistry Letters. 8: 1122-1127. PMID 29057062 DOI: 10.1021/Acsmedchemlett.7B00346 |
0.361 |
|
| 2017 |
Dik DA, Marous DR, Fisher JF, Mobashery S. Lytic transglycosylases: concinnity in concision of the bacterial cell wall. Critical Reviews in Biochemistry and Molecular Biology. 1-40. PMID 28644060 DOI: 10.1080/10409238.2017.1337705 |
0.374 |
|
| 2017 |
Mahasenan KV, Bastian M, Gao M, Frost E, Ding D, Zorina-Lichtenwalter K, Jacobs J, Suckow MA, Schroeder VA, Wolter WR, Chang M, Mobashery S. Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases. Acs Medicinal Chemistry Letters. 8: 654-659. PMID 28626528 DOI: 10.1021/Acsmedchemlett.7B00130 |
0.514 |
|
| 2017 |
Mobashery S, Lee M, Hesek D, Lastochkin E, Boggess B, Dik DA. Deciphering the Nature of Enzymatic Modifications of Bacterial Cell Wall. Chembiochem : a European Journal of Chemical Biology. PMID 28591487 DOI: 10.1002/Cbic.201700293 |
0.346 |
|
| 2017 |
Acebron I, Mahasenan KV, De Benedetti S, Lee M, Artola-Recolons C, Hesek D, Wang H, Hermoso JA, Mobashery S. Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa. Journal of the American Chemical Society. PMID 28482153 DOI: 10.1021/Jacs.7B01626 |
0.348 |
|
| 2017 |
Lee M, Hesek D, Dik DA, Fishovitz J, Lastochkin E, Boggess B, Fisher JF, Mobashery S. From Genome to Proteome to Elucidation of Reactions for All Eleven Known Lytic Transglycosylases from Pseudomonas aeruginosa. Angewandte Chemie (International Ed. in English). PMID 28128504 DOI: 10.1002/Anie.201611279 |
0.394 |
|
| 2017 |
Mahasenan KV, Molina R, Bouley R, Batuecas MT, Fisher JF, Hermoso JA, Chang M, Mobashery S. Conformational dynamics in penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus, allosteric communication network and enablement of catalysis. Journal of the American Chemical Society. PMID 28099001 DOI: 10.1021/Jacs.6B12565 |
0.575 |
|
| 2017 |
Light SH, Cahoon LA, Mahasenan KV, Lee M, Boggess B, Halavaty AS, Mobashery S, Freitag NE, Anderson WF. Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity. Structure (London, England : 1993). PMID 28089449 DOI: 10.1016/J.Str.2016.12.007 |
0.331 |
|
| 2017 |
Dik DA, Dominguez-Gil T, Lee M, Hesek D, Byun B, Fishovitz J, Boggess W, Hellman LM, Fisher JF, Hermoso JA, Mobashery S. Muropeptide Binding and the X-Ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa. Journal of the American Chemical Society. PMID 28079369 DOI: 10.1021/Jacs.6B12819 |
0.328 |
|
| 2016 |
Fisher JF, Mobashery S. Endless Resistance. Endless Antibiotics? Medchemcomm. 7: 37-49. PMID 27746889 DOI: 10.1039/C5Md00394F |
0.379 |
|
| 2016 |
Lee M, Dhar S, De Benedetti S, Hesek D, Boggess B, Blázquez B, Mathee K, Mobashery S. Corrigendum: Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance. Angewandte Chemie (International Ed. in English). 55: 12568. PMID 27676218 DOI: 10.1002/Anie.201608482 |
0.777 |
|
| 2016 |
Domínguez-Gil T, Lee M, Acebrón-Avalos I, Mahasenan KV, Hesek D, Dik DA, Byun B, Lastochkin E, Fisher JF, Mobashery S, Hermoso JA. Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa. Structure (London, England : 1993). PMID 27618662 DOI: 10.1016/J.Str.2016.07.019 |
0.354 |
|
| 2016 |
Gao M, Zhang H, Trivedi A, Mahasenan KV, Schroeder VA, Wolter WR, Suckow MA, Mobashery S, Noble-Haeusslein LJ, Chang M. Selective inhibition of MMP-2 does not alter neurological recovery after spinal cord injury. Acs Chemical Neuroscience. PMID 27551907 DOI: 10.1021/Acschemneuro.6B00217 |
0.458 |
|
| 2016 |
Janardhanan J, Meisel JE, Ding D, Schroeder VA, Wolter WR, Mobashery S, Chang M. In Vitro and In Vivo Synergy of the Oxadiazole Class of Antibacterials with β-Lactams. Antimicrobial Agents and Chemotherapy. PMID 27401567 DOI: 10.1128/Aac.00787-16 |
0.554 |
|
| 2016 |
Rivera I, Molina R, Lee M, Mobashery S, Hermoso JA. Orthologous and Paralogous AmpD Peptidoglycan Amidases from Gram-Negative Bacteria. Microbial Drug Resistance (Larchmont, N.Y.). PMID 27326855 DOI: 10.1089/Mdr.2016.0083 |
0.438 |
|
| 2016 |
Sandalova T, Lee M, Henriques-Normark B, Hesek D, Mobashery S, Mellroth P, Achour A. The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity. Molecular Microbiology. PMID 27273793 DOI: 10.1111/Mmi.13435 |
0.301 |
|
| 2016 |
Janardhanan J, Chang M, Mobashery S. The oxadiazole antibacterials. Current Opinion in Microbiology. 33: 13-17. PMID 27239942 DOI: 10.1016/J.Mib.2016.05.009 |
0.566 |
|
| 2016 |
Lee M, Dhar S, De Benedetti S, Hesek D, Boggess B, Blázquez B, Mathee K, Mobashery S. Muropeptides in Pseudomonas aeruginosa and their Role as Elicitors of β-Lactam-Antibiotic Resistance. Angewandte Chemie (International Ed. in English). PMID 27111486 DOI: 10.1002/Anie.201601693 |
0.775 |
|
| 2016 |
Fisher JF, Mobashery S. β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis. Cold Spring Harbor Perspectives in Medicine. PMID 27091943 DOI: 10.1101/Cshperspect.A025221 |
0.376 |
|
| 2016 |
Bouley R, Ding D, Peng Z, Bastian M, Lastochkin E, Song W, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. Structure-Activity Relationship for the 4(3H)-Quinazolinone Antibacterials. Journal of Medicinal Chemistry. PMID 27088777 DOI: 10.1021/Acs.Jmedchem.6B00372 |
0.534 |
|
| 2016 |
Wang H, Hesek D, Lee M, Lastochkin E, Oliver AG, Chang M, Mobashery S. The Natural Product Essramycin and Three of Its Isomers Are Devoid of Antibacterial Activity. Journal of Natural Products. PMID 27049333 DOI: 10.1021/Acs.Jnatprod.6B00057 |
0.472 |
|
| 2016 |
Lee M, Dominguez-Gil T, Hesek D, Mahasenan KV, Lastochkin E, Hermoso JA, Mobashery S. Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa. Acs Chemical Biology. PMID 27035839 DOI: 10.1021/Acschembio.6B00194 |
0.362 |
|
| 2016 |
Lenz JD, Stohl EA, Robertson R, Hackett KT, Fisher K, Xiong K, Lee M, Hesek D, Mobashery S, Seifert HS, Davies C, Dillard JP. Amidase Activity of AmiC Controls Cell Separation, Stem-peptide Release, and is Enhanced by NlpD in Neisseria gonorrhoeae. The Journal of Biological Chemistry. PMID 26984407 DOI: 10.1074/Jbc.M116.715573 |
0.309 |
|
| 2016 |
Gooyit M, Peng Z, Mobashery S, Chang M. Chapter 10: Thiirane class of gelatinase inhibitors as a privileged template that crosses the blood-brain barrier Rsc Drug Discovery Series. 2016: 262-286. DOI: 10.1039/9781782622246-00262 |
0.729 |
|
| 2015 |
Boudreau MA, Fishovitz J, Llarrull LI, Xiao Q, Mobashery S. Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules. Acs Infectious Diseases. 1: 454-9. PMID 27623311 DOI: 10.1021/Acsinfecdis.5B00086 |
0.414 |
|
| 2015 |
Leemans E, Mahasenan KV, Kumarasiri M, Spink E, Ding D, O'Daniel PI, Boudreau MA, Lastochkin E, Testero SA, Yamaguchi T, Lee M, Hesek D, Fisher JF, Chang M, Mobashery S. Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials. Bioorganic & Medicinal Chemistry Letters. PMID 26733473 DOI: 10.1016/J.Bmcl.2015.12.041 |
0.526 |
|
| 2015 |
Gao M, Nguyen TT, Suckow MA, Wolter WR, Gooyit M, Mobashery S, Chang M. Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 26598687 DOI: 10.1073/Pnas.1517847112 |
0.763 |
|
| 2015 |
Rico-Lastres P, Díez-Martínez R, Iglesias-Bexiga M, Bustamante N, Aldridge C, Hesek D, Lee M, Mobashery S, Gray J, Vollmer W, García P, Menéndez M. Substrate recognition and catalysis by LytB, a pneumococcal peptidoglycan hydrolase involved in virulence. Scientific Reports. 5: 16198. PMID 26537571 DOI: 10.1038/Srep16198 |
0.376 |
|
| 2015 |
Gonzales PR, Pesesky MW, Bouley R, Ballard A, Biddy BA, Suckow MA, Wolter WR, Schroeder VA, Burnham CD, Mobashery S, Chang M, Dantas G. Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA. Nature Chemical Biology. 11: 855-861. PMID 26368589 DOI: 10.1038/Nchembio.1911 |
0.575 |
|
| 2015 |
Kim HS, Im HN, An DR, Yoon JY, Jang JY, Mobashery S, Hesek D, Lee M, Yoo J, Cui M, Choi S, Kim C, Lee NK, Kim SJ, Kim JY, et al. The Cell-Shape Determining Csd6 Protein from Helicobacter pylori Constitutes a New Family of L,D-Carboxypeptidase. The Journal of Biological Chemistry. PMID 26306031 DOI: 10.1074/Jbc.M115.658781 |
0.529 |
|
| 2015 |
Lee M, Chen Z, Tomlinson BN, Gooyit M, Hesek D, Juarez MR, Nizam R, Boggess B, Lastochkin E, Schroeder VA, Wolter WR, Suckow MA, Cui J, Mobashery S, Gu Z, et al. Water-soluble MMP-9 inhibitor reduces lesion volume after severe traumatic brain injury. Acs Chemical Neuroscience. PMID 26241578 DOI: 10.1021/Acschemneuro.5B00140 |
0.761 |
|
| 2015 |
Galimand M, Fishovitz J, Lambert T, Barbe V, Zajicek J, Mobashery S, Courvalin P. AAC(3)-XI, a new aminoglycoside 3-N-acetyltransferase from Corynebacterium striatum. Antimicrobial Agents and Chemotherapy. 59: 5647-53. PMID 26149994 DOI: 10.1128/Aac.01203-15 |
0.34 |
|
| 2015 |
Ding D, Boudreau MA, Leemans E, Spink E, Yamaguchi T, Testero SA, O'Daniel PI, Lastochkin E, Chang M, Mobashery S. Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics. Bioorganic & Medicinal Chemistry Letters. PMID 26144346 DOI: 10.1016/J.Bmcl.2015.06.044 |
0.551 |
|
| 2015 |
Turapov O, Loraine J, Jenkins CH, Barthe P, McFeely D, Forti F, Ghisotti D, Hesek D, Lee M, Bottrill AR, Vollmer W, Mobashery S, Cohen-Gonsaud M, Mukamolova GV. The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth. Open Biology. 5: 150025. PMID 26136255 DOI: 10.1098/Rsob.150025 |
0.319 |
|
| 2015 |
Fishovitz J, Taghizadeh N, Fisher JF, Chang M, Mobashery S. The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA). Journal of the American Chemical Society. 137: 6500-5. PMID 25964995 DOI: 10.1021/Jacs.5B01374 |
0.58 |
|
| 2015 |
Wang H, Lee M, Peng Z, Blázquez B, Lastochkin E, Kumarasiri M, Bouley R, Chang M, Mobashery S. Synthesis and evaluation of 1,2,4-triazolo[1,5-a]pyrimidines as antibacterial agents against Enterococcus faecium. Journal of Medicinal Chemistry. 58: 4194-203. PMID 25923368 DOI: 10.1021/Jm501831G |
0.808 |
|
| 2015 |
Acebrón I, Chang M, Mobashery S, Hermoso JA. The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus. Current Medicinal Chemistry. 22: 1678-86. PMID 25760091 DOI: 10.2174/0929867322666150311150215 |
0.607 |
|
| 2015 |
Staude MW, Frederick TE, Natarajan SV, Wilson BD, Tanner CE, Ruggiero ST, Mobashery S, Peng JW. Investigation of signal transduction routes within the sensor/transducer protein BlaR1 of Staphylococcus aureus. Biochemistry. 54: 1600-10. PMID 25658195 DOI: 10.1021/Bi501463K |
0.385 |
|
| 2015 |
Bouley R, Kumarasiri M, Peng Z, Otero LH, Song W, Suckow MA, Schroeder VA, Wolter WR, Lastochkin E, Antunes NT, Pi H, Vakulenko S, Hermoso JA, Chang M, Mobashery S. Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one. Journal of the American Chemical Society. 137: 1738-41. PMID 25629446 DOI: 10.1021/Jacs.5B00056 |
0.528 |
|
| 2015 |
Spink E, Ding D, Peng Z, Boudreau MA, Leemans E, Lastochkin E, Song W, Lichtenwalter K, O'Daniel PI, Testero SA, Pi H, Schroeder VA, Wolter WR, Antunes NT, Suckow MA, ... ... Mobashery S, et al. Structure-activity relationship for the oxadiazole class of antibiotics. Journal of Medicinal Chemistry. 58: 1380-9. PMID 25590813 DOI: 10.1021/Jm501661F |
0.578 |
|
| 2015 |
Lee M, Hesek D, Blázquez B, Lastochkin E, Boggess B, Fisher JF, Mobashery S. Catalytic spectrum of the penicillin-binding protein 4 of Pseudomonas aeruginosa, a nexus for the induction of β-lactam antibiotic resistance. Journal of the American Chemical Society. 137: 190-200. PMID 25495032 DOI: 10.1021/Ja5111706 |
0.8 |
|
| 2015 |
Gao M, Nguyen TT, Suckow MA, Wolter WR, Gooyit M, Mobashery S, Chang M. Acceleration of diabetic wound healing using a novel proteaseanti-protease combination therapy Proceedings of the National Academy of Sciences of the United States of America. 112: 15226-15231. DOI: 10.1073/pnas.1517847112/-/DCSupplemental |
0.729 |
|
| 2014 |
Xiao Q, Vakulenko S, Chang M, Mobashery S. Mutations in mmpL and in the cell wall stress stimulon contribute to resistance to oxadiazole antibiotics in methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 58: 5841-7. PMID 25049248 DOI: 10.1128/Aac.03501-14 |
0.551 |
|
| 2014 |
Fishovitz J, Hermoso JA, Chang M, Mobashery S. Penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. Iubmb Life. 66: 572-7. PMID 25044998 DOI: 10.1002/Iub.1289 |
0.595 |
|
| 2014 |
Artola-Recolons C, Lee M, Bernardo-García N, Blázquez B, Hesek D, Bartual SG, Mahasenan KV, Lastochkin E, Pi H, Boggess B, Meindl K, Usón I, Fisher JF, Mobashery S, Hermoso JA. Structure and cell wall cleavage by modular lytic transglycosylase MltC of Escherichia coli. Acs Chemical Biology. 9: 2058-66. PMID 24988330 DOI: 10.1021/Cb500439C |
0.756 |
|
| 2014 |
Fishovitz J, Rojas-Altuve A, Otero LH, Dawley M, Carrasco-López C, Chang M, Hermoso JA, Mobashery S. Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics. Journal of the American Chemical Society. 136: 9814-7. PMID 24955778 DOI: 10.1021/Ja5030657 |
0.601 |
|
| 2014 |
Fisher JF, Mobashery S. The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa. Bioorganic Chemistry. 56: 41-8. PMID 24955547 DOI: 10.1016/J.Bioorg.2014.05.011 |
0.365 |
|
| 2014 |
Blázquez B, Llarrull LI, Luque-Ortega JR, Alfonso C, Boggess B, Mobashery S. Regulation of the expression of the β-lactam antibiotic-resistance determinants in methicillin-resistant Staphylococcus aureus (MRSA). Biochemistry. 53: 1548-50. PMID 24564530 DOI: 10.1021/Bi500074W |
0.784 |
|
| 2014 |
Mellroth P, Sandalova T, Kikhney A, Vilaplana F, Hesek D, Lee M, Mobashery S, Normark S, Svergun D, Henriques-Normark B, Achour A. Structural and functional insights into peptidoglycan access for the lytic amidase LytA of Streptococcus pneumoniae. Mbio. 5: e01120-13. PMID 24520066 DOI: 10.1128/Mbio.01120-13 |
0.372 |
|
| 2014 |
O'Daniel PI, Peng Z, Pi H, Testero SA, Ding D, Spink E, Leemans E, Boudreau MA, Yamaguchi T, Schroeder VA, Wolter WR, Llarrull LI, Song W, Lastochkin E, Kumarasiri M, ... ... Mobashery S, et al. Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity. Journal of the American Chemical Society. 136: 3664-72. PMID 24517363 DOI: 10.1021/Ja500053X |
0.583 |
|
| 2014 |
Kumarasiri M, Zhang W, Shi Q, Fisher JF, Mobashery S. Protonation states of active-site lysines of penicillin-binding protein 6 from Escherichia coli and the mechanistic implications. Proteins. 82: 1348-58. PMID 24375650 DOI: 10.1002/Prot.24501 |
0.341 |
|
| 2014 |
Frederick TE, Wilson BD, Cha J, Mobashery S, Peng JW. Revealing cell-surface intramolecular interactions in the BlaR1 protein of methicillin-resistant Staphylococcus aureus by NMR spectroscopy. Biochemistry. 53: 10-2. PMID 24359467 DOI: 10.1021/Bi401552J |
0.581 |
|
| 2014 |
Gooyit M, Peng Z, Wolter WR, Pi H, Ding D, Hesek D, Lee M, Boggess B, Champion MM, Suckow MA, Mobashery S, Chang M. A chemical biological strategy to facilitate diabetic wound healing. Acs Chemical Biology. 9: 105-10. PMID 24053680 DOI: 10.1021/Cb4005468 |
0.765 |
|
| 2014 |
Ding D, Lichtenwalter K, Pi H, Mobashery S, Chang M. Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8) Medchemcomm. 5: 1381-1383. DOI: 10.1039/C4Md00172A |
0.501 |
|
| 2014 |
Fisher JF, Mobashery S. Erratum to “The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa” [Bioorg. Chem. 56C (2014) 41–48] Bioorganic Chemistry. 55: 78. DOI: 10.1016/J.Bioorg.2014.07.006 |
0.35 |
|
| 2013 |
Hadass O, Tomlinson BN, Gooyit M, Chen S, Purdy JJ, Walker JM, Zhang C, Giritharan AB, Purnell W, Robinson CR, Shin D, Schroeder VA, Suckow MA, Simonyi A, Sun GY, ... Mobashery S, et al. Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury. Plos One. 8: e76904. PMID 24194849 DOI: 10.1371/Journal.Pone.0076904 |
0.756 |
|
| 2013 |
Otero LH, Rojas-Altuve A, Llarrull LI, Carrasco-López C, Kumarasiri M, Lastochkin E, Fishovitz J, Dawley M, Hesek D, Lee M, Johnson JW, Fisher JF, Chang M, Mobashery S, Hermoso JA. How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function. Proceedings of the National Academy of Sciences of the United States of America. 110: 16808-13. PMID 24085846 DOI: 10.1073/Pnas.1300118110 |
0.743 |
|
| 2013 |
Gooyit M, Song W, Mahasenan KV, Lichtenwalter K, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. O-phenyl carbamate and phenyl urea thiiranes as selective matrix metalloproteinase-2 inhibitors that cross the blood-brain barrier. Journal of Medicinal Chemistry. 56: 8139-50. PMID 24028490 DOI: 10.1021/Jm401217D |
0.757 |
|
| 2013 |
Smith CA, Antunes NT, Stewart NK, Toth M, Kumarasiri M, Chang M, Mobashery S, Vakulenko SB. Structural basis for carbapenemase activity of the OXA-23 β-lactamase from Acinetobacter baumannii. Chemistry & Biology. 20: 1107-15. PMID 24012371 DOI: 10.1016/J.Chembiol.2013.07.015 |
0.58 |
|
| 2013 |
Lee M, Artola-Recolons C, Carrasco-López C, Martínez-Caballero S, Hesek D, Spink E, Lastochkin E, Zhang W, Hellman LM, Boggess B, Hermoso JA, Mobashery S. Cell-wall remodeling by the zinc-protease AmpDh3 from Pseudomonas aeruginosa. Journal of the American Chemical Society. 135: 12604-7. PMID 23931161 DOI: 10.1021/Ja407445X |
0.325 |
|
| 2013 |
Martínez-Caballero S, Lee M, Artola-Recolons C, Carrasco-López C, Hesek D, Spink E, Lastochkin E, Zhang W, Hellman LM, Boggess B, Mobashery S, Hermoso JA. Reaction products and the X-ray structure of AmpDh2, a virulence determinant of Pseudomonas aeruginosa. Journal of the American Chemical Society. 135: 10318-21. PMID 23819763 DOI: 10.1021/Ja405464B |
0.333 |
|
| 2013 |
Smith JD, Kumarasiri M, Zhang W, Hesek D, Lee M, Toth M, Vakulenko S, Fisher JF, Mobashery S, Chen Y. Structural analysis of the role of Pseudomonas aeruginosa penicillin-binding protein 5 in β-lactam resistance. Antimicrobial Agents and Chemotherapy. 57: 3137-46. PMID 23629710 DOI: 10.1128/Aac.00505-13 |
0.447 |
|
| 2013 |
Fu HL, Sohail A, Valiathan RR, Wasinski BD, Kumarasiri M, Mahasenan KV, Bernardo MM, Tokmina-Roszyk D, Fields GB, Mobashery S, Fridman R. Shedding of discoidin domain receptor 1 by membrane-type matrix metalloproteinases. The Journal of Biological Chemistry. 288: 12114-29. PMID 23519472 DOI: 10.1074/Jbc.M112.409599 |
0.313 |
|
| 2013 |
Zhang W, Lee M, Hesek D, Lastochkin E, Boggess B, Mobashery S. Reactions of the three AmpD enzymes of Pseudomonas aeruginosa. Journal of the American Chemical Society. 135: 4950-3. PMID 23510438 DOI: 10.1021/Ja400970N |
0.384 |
|
| 2013 |
Lee M, Hesek D, Llarrull LI, Lastochkin E, Pi H, Boggess B, Mobashery S. Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. Journal of the American Chemical Society. 135: 3311-4. PMID 23421439 DOI: 10.1021/Ja309036Q |
0.354 |
|
| 2013 |
Johnson JW, Fisher JF, Mobashery S. Bacterial cell-wall recycling. Annals of the New York Academy of Sciences. 1277: 54-75. PMID 23163477 DOI: 10.1111/J.1749-6632.2012.06813.X |
0.66 |
|
| 2012 |
Smith CA, Frase H, Toth M, Kumarasiri M, Wiafe K, Munoz J, Mobashery S, Vakulenko SB. Structural basis for progression toward the carbapenemase activity in the GES family of β-lactamases. Journal of the American Chemical Society. 134: 19512-5. PMID 23148776 DOI: 10.1021/Ja308197J |
0.391 |
|
| 2012 |
Gooyit M, Suckow MA, Schroeder VA, Wolter WR, Mobashery S, Chang M. Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. Acs Chemical Neuroscience. 3: 730-6. PMID 23077716 DOI: 10.1021/Cn300062W |
0.755 |
|
| 2012 |
Yamaguchi T, Blázquez B, Hesek D, Lee M, Llarrull LI, Boggess B, Oliver AG, Fisher JF, Mobashery S. Inhibitors for Bacterial Cell-Wall Recycling. Acs Medicinal Chemistry Letters. 3: 238-242. PMID 22844551 DOI: 10.1021/Ml2002746 |
0.756 |
|
| 2012 |
Makino H, Tada Y, Wada K, Liang EI, Chang M, Mobashery S, Kanematsu Y, Kurihara C, Palova E, Kanematsu M, Kitazato K, Hashimoto T. Pharmacological stabilization of intracranial aneurysms in mice: a feasibility study. Stroke; a Journal of Cerebral Circulation. 43: 2450-6. PMID 22798328 DOI: 10.1161/Strokeaha.112.659821 |
0.426 |
|
| 2012 |
Lee M, Ikejiri M, Klimpel D, Toth M, Espahbodi M, Hesek D, Forbes C, Kumarasiri M, Noll BC, Chang M, Mobashery S. Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors. Acs Medicinal Chemistry Letters. 3: 490-495. PMID 22737278 DOI: 10.1021/Ml300050B |
0.5 |
|
| 2012 |
Llarrull LI, Mobashery S. Dissection of events in the resistance to β-lactam antibiotics mediated by the protein BlaR1 from Staphylococcus aureus. Biochemistry. 51: 4642-9. PMID 22616850 DOI: 10.1021/Bi300429P |
0.404 |
|
| 2012 |
Cui J, Chen S, Zhang C, Meng F, Wu W, Hu R, Hadass O, Lehmidi T, Blair GJ, Lee M, Chang M, Mobashery S, Sun GY, Gu Z. Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia. Molecular Neurodegeneration. 7: 21. PMID 22587708 DOI: 10.1186/1750-1326-7-21 |
0.483 |
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| 2012 |
Boudreau MA, Fisher JF, Mobashery S. Messenger functions of the bacterial cell wall-derived muropeptides. Biochemistry. 51: 2974-90. PMID 22409164 DOI: 10.1021/Bi300174X |
0.329 |
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| 2012 |
Kumarasiri M, Llarrull LI, Borbulevych O, Fishovitz J, Lastochkin E, Baker BM, Mobashery S. An amino acid position at crossroads of evolution of protein function: antibiotic sensor domain of BlaR1 protein from Staphylococcus aureus versus clasS D β-lactamases. The Journal of Biological Chemistry. 287: 8232-41. PMID 22262858 DOI: 10.1074/Jbc.M111.333179 |
0.378 |
|
| 2012 |
Park JS, Lee WC, Yeo KJ, Ryu KS, Kumarasiri M, Hesek D, Lee M, Mobashery S, Song JH, Kim SI, Lee JC, Cheong C, Jeon YH, Kim HY. Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram-negative bacterial outer membrane. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 219-28. PMID 21965596 DOI: 10.1096/Fj.11-188425 |
0.328 |
|
| 2011 |
Testero SA, Llarrull LI, Fisher JF, Chang M, Mobashery S. Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry. Arkivoc : Free Online Journal of Organic Chemistry. 2011: 221-226. PMID 32774191 DOI: 10.3998/Ark.5550190.0012.719 |
0.529 |
|
| 2011 |
Testero SA, Lee M, Staran RT, Espahbodi M, Llarrull LI, Toth M, Mobashery S, Chang M. Sulfonate-containing thiiranes as selective gelatinase inhibitors. Acs Medicinal Chemistry Letters. 2: 177-81. PMID 24900296 DOI: 10.1021/Ml100254E |
0.51 |
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| 2011 |
Bush K, Courvalin P, Dantas G, Davies J, Eisenstein B, Huovinen P, Jacoby GA, Kishony R, Kreiswirth BN, Kutter E, Lerner SA, Levy S, Lewis K, Lomovskaya O, Miller JH, ... Mobashery S, et al. Tackling antibiotic resistance. Nature Reviews. Microbiology. 9: 894-6. PMID 22048738 DOI: 10.1038/Nrmicro2693 |
0.381 |
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| 2011 |
Llarrull LI, Toth M, Champion MM, Mobashery S. Activation of BlaR1 protein of methicillin-resistant Staphylococcus aureus, its proteolytic processing, and recovery from induction of resistance. The Journal of Biological Chemistry. 286: 38148-58. PMID 21896485 DOI: 10.1074/Jbc.M111.288985 |
0.403 |
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| 2011 |
Gooyit M, Lee M, Schroeder VA, Ikejiri M, Suckow MA, Mobashery S, Chang M. Selective water-soluble gelatinase inhibitor prodrugs. Journal of Medicinal Chemistry. 54: 6676-90. PMID 21866961 DOI: 10.1021/Jm200566E |
0.759 |
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| 2011 |
Sohail A, Marco M, Zhao H, Shi Q, Merriman S, Mobashery S, Fridman R. Characterization of the dimerization interface of membrane type 4 (MT4)-matrix metalloproteinase. The Journal of Biological Chemistry. 286: 33178-89. PMID 21828052 DOI: 10.1074/Jbc.M111.253369 |
0.318 |
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| 2011 |
Borbulevych O, Kumarasiri M, Wilson B, Llarrull LI, Lee M, Hesek D, Shi Q, Peng J, Baker BM, Mobashery S. Lysine Nzeta-decarboxylation switch and activation of the beta-lactam sensor domain of BlaR1 protein of methicillin-resistant Staphylococcus aureus. The Journal of Biological Chemistry. 286: 31466-72. PMID 21775440 DOI: 10.1074/Jbc.M111.252189 |
0.41 |
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| 2011 |
Carrasco-López C, Rojas-Altuve A, Zhang W, Hesek D, Lee M, Barbe S, André I, Ferrer P, Silva-Martin N, Castro GR, MartÃnez-Ripoll M, Mobashery S, Hermoso JA. Crystal structures of bacterial peptidoglycan amidase AmpD and an unprecedented activation mechanism. The Journal of Biological Chemistry. 286: 31714-22. PMID 21775432 DOI: 10.1107/S0108767311094360 |
0.372 |
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| 2011 |
Antunes NT, Frase H, Toth M, Mobashery S, Vakulenko SB. Resistance to the third-generation cephalosporin ceftazidime by a deacylation-deficient mutant of the TEM β-lactamase by the uncommon covalent-trapping mechanism. Biochemistry. 50: 6387-95. PMID 21696166 DOI: 10.1021/Bi200403E |
0.391 |
|
| 2011 |
Shi Q, Meroueh SO, Fisher JF, Mobashery S. A computational evaluation of the mechanism of penicillin-binding protein-catalyzed cross-linking of the bacterial cell wall. Journal of the American Chemical Society. 133: 5274-83. PMID 21417389 DOI: 10.1021/Ja1074739 |
0.381 |
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| 2011 |
Frase H, Smith CA, Toth M, Champion MM, Mobashery S, Vakulenko SB. Identification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry. The Journal of Biological Chemistry. 286: 14396-409. PMID 21345789 DOI: 10.1074/Jbc.M110.208744 |
0.39 |
|
| 2011 |
Artola-Recolons C, Carrasco-López C, Llarrull LI, Kumarasiri M, Lastochkin E, Martínez de Ilarduya I, Meindl K, Usón I, Mobashery S, Hermoso JA. High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli. Biochemistry. 50: 2384-6. PMID 21341761 DOI: 10.1021/Bi200085Y |
0.335 |
|
| 2011 |
Testero SA, Bouley R, Fisher JF, Chang M, Mobashery S. Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases. Bioorganic & Medicinal Chemistry Letters. 21: 2675-8. PMID 21256011 DOI: 10.1016/J.Bmcl.2010.12.076 |
0.475 |
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| 2011 |
Maestro B, Novaková L, Hesek D, Lee M, Leyva E, Mobashery S, Sanz JM, Branny P. Recognition of peptidoglycan and β-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae. Febs Letters. 585: 357-63. PMID 21167155 DOI: 10.1016/J.Febslet.2010.12.016 |
0.332 |
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| 2011 |
Chongsiriwatana NP, Miller TM, Wetzler M, Vakulenko S, Karlsson AJ, Palecek SP, Mobashery S, Barron AE. Short alkylated peptoid mimics of antimicrobial lipopeptides. Antimicrobial Agents and Chemotherapy. 55: 417-20. PMID 20956607 DOI: 10.1128/Aac.01080-10 |
0.336 |
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| 2011 |
Benson HL, Mobashery S, Chang M, Kheradmand F, Hong JS, Smith GN, Shilling RA, Wilkes DS. Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells. American Journal of Respiratory Cell and Molecular Biology. 44: 700-8. PMID 20639459 DOI: 10.1165/Rcmb.2010-0125Oc |
0.47 |
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| 2010 |
Lee M, Hesek D, Shah IM, Oliver AG, Dworkin J, Mobashery S. Synthetic peptidoglycan motifs for germination of bacterial spores. Chembiochem : a European Journal of Chemical Biology. 11: 2525-9. PMID 21117117 DOI: 10.1002/Cbic.201000626 |
0.327 |
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| 2010 |
Zhou J, Tao P, Fisher JF, Shi Q, Mobashery S, Schlegel HB. QM/MM Studies of the Matrix Metalloproteinase 2 (MMP2) Inhibition Mechanism of (S)-SB-3CT and its Oxirane Analogue. Journal of Chemical Theory and Computation. 6: 3580-3587. PMID 21076643 DOI: 10.1021/Ct100382K |
0.311 |
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| 2010 |
Llarrull LI, Testero SA, Fisher JF, Mobashery S. The future of the β-lactams. Current Opinion in Microbiology. 13: 551-7. PMID 20888287 DOI: 10.1016/J.Mib.2010.09.008 |
0.396 |
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| 2010 |
Llarrull LI, Prorok M, Mobashery S. Binding of the gene repressor BlaI to the bla operon in methicillin-resistant Staphylococcus aureus. Biochemistry. 49: 7975-7. PMID 20722402 DOI: 10.1021/Bi101177A |
0.379 |
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| 2010 |
Fisher JF, Mobashery S. Host-guest chemistry of the peptidoglycan. Journal of Medicinal Chemistry. 53: 4813-29. PMID 20524613 DOI: 10.1021/Jm100086U |
0.351 |
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| 2010 |
Bernal P, Lemaire S, Pinho MG, Mobashery S, Hinds J, Taylor PW. Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2. The Journal of Biological Chemistry. 285: 24055-65. PMID 20516078 DOI: 10.1074/Jbc.M110.114793 |
0.431 |
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| 2010 |
Pérez-Dorado I, González A, Morales M, Sanles R, Striker W, Vollmer W, Mobashery S, García JL, Martínez-Ripoll M, García P, Hermoso JA. Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC. Nature Structural & Molecular Biology. 17: 576-81. PMID 20400948 DOI: 10.1038/Nsmb.1817 |
0.343 |
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| 2010 |
Fisher JF, Mobashery S. Mechanism-based profiling of MMPs. Methods in Molecular Biology (Clifton, N.J.). 622: 471-87. PMID 20135299 DOI: 10.1007/978-1-60327-299-5_27 |
0.311 |
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| 2010 |
Toth M, Smith C, Frase H, Mobashery S, Vakulenko S. An antibiotic-resistance enzyme from a deep-sea bacterium. Journal of the American Chemical Society. 132: 816-23. PMID 20000704 DOI: 10.1021/Ja908850P |
0.417 |
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| 2010 |
Fernández D, Testero S, Vendrell J, Avilés FX, Mobashery S. The X-ray structure of carboxypeptidase A inhibited by a thiirane mechanism-based inhibitor. Chemical Biology & Drug Design. 75: 29-34. PMID 19895506 DOI: 10.1111/J.1747-0285.2009.00907.X |
0.326 |
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| 2010 |
Testero SA, Fisher JF, Mobashery S. β-Lactam Antibiotics Burger's Medicinal Chemistry and Drug Discovery. 257-402. DOI: 10.1002/0471266949.Bmc226 |
0.333 |
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| 2009 |
Gooyit M, Lee M, Hesek D, Boggess B, Oliver AG, Fridman R, Mobashery S, Chang M. Synthesis, kinetic characterization and metabolism of diastereomeric 2-(1-(4-phenoxyphenylsulfonyl)ethyl)thiiranes as potent gelatinase and MT1-MMP inhibitors. Chemical Biology & Drug Design. 74: 535-46. PMID 19824893 DOI: 10.1111/J.1747-0285.2009.00898.X |
0.774 |
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| 2009 |
Forbes C, Shi Q, Fisher JF, Lee M, Hesek D, Llarrull LI, Toth M, Gossing M, Fridman R, Mobashery S. Active site ring-opening of a thiirane moiety and picomolar inhibition of gelatinases. Chemical Biology & Drug Design. 74: 527-34. PMID 19807733 DOI: 10.1111/J.1747-0285.2009.00881.X |
0.376 |
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| 2009 |
Chen Y, Zhang W, Shi Q, Hesek D, Lee M, Mobashery S, Shoichet BK. Crystal structures of penicillin-binding protein 6 from Escherichia coli. Journal of the American Chemical Society. 131: 14345-54. PMID 19807181 DOI: 10.1021/Ja903773F |
0.384 |
|
| 2009 |
Tao P, Fisher JF, Shi Q, Vreven T, Mobashery S, Schlegel HB. Matrix metalloproteinase 2 inhibition: combined quantum mechanics and molecular mechanics studies of the inhibition mechanism of (4-phenoxyphenylsulfonyl)methylthiirane and its oxirane analogue. Biochemistry. 48: 9839-47. PMID 19754151 DOI: 10.1021/Bi901118R |
0.313 |
|
| 2009 |
Frase H, Shi Q, Testero SA, Mobashery S, Vakulenko SB. Mechanistic basis for the emergence of catalytic competence against carbapenem antibiotics by the GES family of beta-lactamases. The Journal of Biological Chemistry. 284: 29509-13. PMID 19656947 DOI: 10.1074/Jbc.M109.011262 |
0.418 |
|
| 2009 |
Zhang W, Fisher JF, Mobashery S. The bifunctional enzymes of antibiotic resistance. Current Opinion in Microbiology. 12: 505-11. PMID 19615931 DOI: 10.1016/J.Mib.2009.06.013 |
0.422 |
|
| 2009 |
Fisher JF, Mobashery S. Three decades of the class A beta-lactamase acyl-enzyme. Current Protein & Peptide Science. 10: 401-7. PMID 19538154 DOI: 10.2174/138920309789351967 |
0.384 |
|
| 2009 |
Ota R, Kurihara C, Tsou TL, Young WL, Yeghiazarians Y, Chang M, Mobashery S, Sakamoto A, Hashimoto T. Roles of matrix metalloproteinases in flow-induced outward vascular remodeling. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 1547-58. PMID 19513084 DOI: 10.1038/Jcbfm.2009.77 |
0.456 |
|
| 2009 |
Lee M, Zhang W, Hesek D, Noll BC, Boggess B, Mobashery S. Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance. Journal of the American Chemical Society. 131: 8742-3. PMID 19496566 DOI: 10.1021/Ja9025566 |
0.408 |
|
| 2009 |
Llarrull LI, Fisher JF, Mobashery S. Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge. Antimicrobial Agents and Chemotherapy. 53: 4051-63. PMID 19470504 DOI: 10.1128/Aac.00084-09 |
0.439 |
|
| 2009 |
Hesek D, Lee M, Zhang W, Noll BC, Mobashery S. Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli. Journal of the American Chemical Society. 131: 5187-93. PMID 19309146 DOI: 10.1021/Ja808498M |
0.337 |
|
| 2009 |
Lee M, Celenza G, Boggess B, Blase J, Shi Q, Toth M, Bernardo MM, Wolter WR, Suckow MA, Hesek D, Noll BC, Fridman R, Mobashery S, Chang M. A potent gelatinase inhibitor with anti-tumor-invasive activity and its metabolic disposition. Chemical Biology & Drug Design. 73: 189-202. PMID 19207421 DOI: 10.1111/J.1747-0285.2008.00750.X |
0.483 |
|
| 2009 |
Molina R, González A, Stelter M, Pérez-Dorado I, Kahn R, Morales M, Moscoso M, Campuzano S, Campillo NE, Mobashery S, GarcÃa JL, GarcÃa P, Hermoso JA. Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae. Embo Reports. 10: 246-51. PMID 19165143 DOI: 10.1038/Embor.2008.245 |
0.314 |
|
| 2009 |
Toth M, Chow JW, Mobashery S, Vakulenko SB. Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases. The Journal of Biological Chemistry. 284: 6690-6. PMID 19158087 DOI: 10.1074/Jbc.M808148200 |
0.404 |
|
| 2008 |
Zhao H, Sohail A, Sun Q, Shi Q, Kim S, Mobashery S, Fridman R. Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25). The Journal of Biological Chemistry. 283: 35023-32. PMID 18936094 DOI: 10.1074/Jbc.M806553200 |
0.313 |
|
| 2008 |
Suvorov M, Lee M, Hesek D, Boggess B, Mobashery S. Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall. Journal of the American Chemical Society. 130: 11878-9. PMID 18700763 DOI: 10.1021/Ja805482B |
0.71 |
|
| 2008 |
Martin MD, Carter KJ, Jean-Philippe SR, Chang M, Mobashery S, Thiolloy S, Lynch CC, Matrisian LM, Fingleton B. Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Research. 68: 6251-9. PMID 18676849 DOI: 10.1158/0008-5472.Can-08-0537 |
0.479 |
|
| 2008 |
Villegas-Estrada A, Lee M, Hesek D, Vakulenko SB, Mobashery S. Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics. Journal of the American Chemical Society. 130: 9212-3. PMID 18582062 DOI: 10.1021/Ja8029448 |
0.446 |
|
| 2008 |
Shi Q, Meroueh SO, Fisher JF, Mobashery S. Investigation of the mechanism of the cell wall DD-carboxypeptidase reaction of penicillin-binding protein 5 of Escherichia coli by quantum mechanics/molecular mechanics calculations. Journal of the American Chemical Society. 130: 9293-303. PMID 18576637 DOI: 10.1021/Ja801727K |
0.322 |
|
| 2008 |
Lemaire S, Fuda C, Van Bambeke F, Tulkens PM, Mobashery S. Restoration of susceptibility of methicillin-resistant Staphylococcus aureus to β-lactam antibiotics by acidic pH: Role of penicillin-binding protein PBP Journal of Biological Chemistry. 283: 12769-12776. PMID 18337244 DOI: 10.1074/Jbc.M800079200 |
0.799 |
|
| 2008 |
Totir MA, Cha J, Ishiwata A, Wang B, Sheri A, Anderson VE, Buynak J, Mobashery S, Carey PR. Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence. Biochemistry. 47: 4094-101. PMID 18324783 DOI: 10.1021/Bi702348W |
0.576 |
|
| 2008 |
Celenza G, Villegas-Estrada A, Lee M, Boggess B, Forbes C, Wolter WR, Suckow MA, Mobashery S, Chang M. Metabolism of (4-phenoxyphenylsulfonyl) methylthiirane, a selective gelatinase inhibitor. Chemical Biology & Drug Design. 71: 187-96. PMID 18221479 DOI: 10.1111/J.1747-0285.2008.00632.X |
0.463 |
|
| 2008 |
Badarau A, Shi Q, Chow JW, Zajicek J, Mobashery S, Vakulenko S. Aminoglycoside 2″-phosphotransferase type IIIa from Enterococcus Journal of Biological Chemistry. 283: 7638-7647. PMID 18199745 DOI: 10.1074/Jbc.M709645200 |
0.369 |
|
| 2008 |
Kim DH, Lilliehook C, Roides B, Chen Z, Chang M, Mobashery S, Goldman SA. Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 208-16. PMID 18171938 DOI: 10.1523/Jneurosci.3674-07.2008 |
0.472 |
|
| 2008 |
Lee M, Hesek D, Shi Q, Noll BC, Fisher JF, Chang M, Mobashery S. Conformational analyses of thiirane-based gelatinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 3064-7. PMID 18083555 DOI: 10.1016/J.Bmcl.2007.11.131 |
0.494 |
|
| 2007 |
Brickner SJ, Mobashery S. Prospects of therapies targeting resistant bacteria-New challenges 20 years post emergence of vancomycin-resistant enterococcus Current Opinion in Microbiology. 10: 425-427. PMID 17951102 DOI: 10.1016/J.Mib.2007.09.002 |
0.353 |
|
| 2007 |
Rosenblum G, Meroueh S, Toth M, Fisher JF, Fridman R, Mobashery S, Sagi I. Molecular structures and dynamics of the stepwise activation mechanism of a matrix metalloproteinase zymogen: Challenging the cysteine switch dogma Journal of the American Chemical Society. 129: 13566-13574. PMID 17929919 DOI: 10.1021/Ja073941L |
0.347 |
|
| 2007 |
Lee M, Villegas-Estrada A, Celenza G, Boggess B, Toth M, Kreitinger G, Forbes C, Fridman R, Mobashery S, Chang M. Metabolism of a highly selective gelatinase inhibitor generates active metabolite. Chemical Biology & Drug Design. 70: 371-82. PMID 17927722 DOI: 10.1111/J.1747-0285.2007.00577.X |
0.508 |
|
| 2007 |
Zhang W, Shi Q, Meroueh SO, Vakulenko SB, Mobashery S. Catalytic mechanism of penicillin-binding protein 5 of Escherichia coli Biochemistry. 46: 10113-10121. PMID 17685588 DOI: 10.1021/Bi700777X |
0.373 |
|
| 2007 |
Pérez-Dorado I, Campillo NE, Monterroso B, Hesek D, Lee M, Páez JA, García P, Martínez-Ripoll M, García JL, Mobashery S, Menéndez M, Hermoso JA. Elucidation of the molecular recognition of bacterial cell wall by modular pneumococcal phage endolysin CPL-1 Journal of Biological Chemistry. 282: 24990-24999. PMID 17581815 DOI: 10.1074/Jbc.M704317200 |
0.361 |
|
| 2007 |
Fuda C, Suvorov M, Shi Q, Hesek D, Lee M, Mobashery S. Shared functional attributes between the mecA gene product of Staphylococcus sciuri and penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. Biochemistry. 46: 8050-7. PMID 17567045 DOI: 10.1021/Bi7004587 |
0.802 |
|
| 2007 |
Cha J, Vakulenko SB, Mobashery S. Characterization of the beta-lactam antibiotic sensor domain of the MecR1 signal sensor/transducer protein from methicillin-resistant Staphylococcus aureus. Biochemistry. 46: 7822-31. PMID 17550272 DOI: 10.1021/Bi7005459 |
0.587 |
|
| 2007 |
Meroueh SO, Mobashery S. Conformational transition in the aminoacyl t-RNA site of the bacterial ribosome both in the presence and absence of an aminoglycoside antibiotic Chemical Biology and Drug Design. 69: 291-297. PMID 17539821 DOI: 10.1111/J.1747-0285.2007.00505.X |
0.314 |
|
| 2007 |
Cho S, Wang Q, Swaminathan CP, Hesek D, Lee M, Boons GJ, Mobashery S, Mariuzza RA. Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins. Proceedings of the National Academy of Sciences of the United States of America. 104: 8761-6. PMID 17502600 DOI: 10.1073/Pnas.0701453104 |
0.366 |
|
| 2007 |
Suvorov M, Vakulenko SB, Mobashery S. Cytoplasmic-membrane anchoring of a class A beta-lactamase and its capacity in manifesting antibiotic resistance. Antimicrobial Agents and Chemotherapy. 51: 2937-42. PMID 17502412 DOI: 10.1128/Aac.00011-07 |
0.73 |
|
| 2007 |
Toth M, Zajicek J, Kim C, Chow JW, Smith C, Mobashery S, Vakulenko S. Kinetic mechanism of enterococcal aminoglycoside phosphotransferase 2"-Ib. Biochemistry. 46: 5570-8. PMID 17425289 DOI: 10.1021/Bi6024512 |
0.609 |
|
| 2007 |
Kim C, Villegas-Estrada A, Hesek D, Mobashery S. Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib/AAC(6')-Ib' from Pseudomonas aeruginosa. Biochemistry. 46: 5270-82. PMID 17417880 DOI: 10.1021/Bi700111Z |
0.609 |
|
| 2007 |
Cha J, Mobashery S. Lysine N(zeta)-decarboxylation in the BlaR1 protein from Staphylococcus aureus at the root of its function as an antibiotic sensor. Journal of the American Chemical Society. 129: 3834-5. PMID 17343387 DOI: 10.1021/Ja070472E |
0.588 |
|
| 2006 |
Kim C, Hesek D, Zajícek J, Vakulenko SB, Mobashery S. Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3'')-Ii/AAC(6')-IId from Serratia marcescens. Biochemistry. 45: 8368-77. PMID 16819836 DOI: 10.1021/Bi060723G |
0.618 |
|
| 2006 |
Thumanu K, Cha J, Fisher JF, Perrins R, Mobashery S, Wharton C. Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium. Proceedings of the National Academy of Sciences of the United States of America. 103: 10630-5. PMID 16815972 DOI: 10.1073/Pnas.0601971103 |
0.567 |
|
| 2006 |
Rekharsky M, Hesek D, Lee M, Meroueh SO, Inoue Y, Mobashery S. Thermodynamics of interactions of vancomycin and synthetic surrogates of bacterial cell wall Journal of the American Chemical Society. 128: 7736-7737. PMID 16771477 DOI: 10.1021/Ja061828+ |
0.301 |
|
| 2006 |
Fisher JF, Mobashery S. Recent advances in MMP inhibitor design Cancer and Metastasis Reviews. 25: 115-136. PMID 16680577 DOI: 10.1007/S10555-006-7894-9 |
0.33 |
|
| 2006 |
Hesek D, Toth M, Meroueh SO, Brown S, Zhao H, Sakr W, Fridman R, Mobashery S. Design and Characterization of a Metalloproteinase Inhibitor-Tethered Resin for the Detection of Active MMPs in Biological Samples Chemistry and Biology. 13: 379-386. PMID 16632250 DOI: 10.1016/J.Chembiol.2006.01.012 |
0.325 |
|
| 2006 |
Hesek D, Noll BC, Mobashery S. Side reaction of significance in preparation of peptide- or peptidomimetic-based hydroxamate enzyme inhibitors Journal of Organic Chemistry. 71: 2885-2887. PMID 16555848 DOI: 10.1021/Jo052546F |
0.328 |
|
| 2006 |
Meroueh SO, Bencze KZ, Hesek D, Lee M, Fisher JF, Stemmler TL, Mobashery S. Three-dimensional structure of the bacterial cell wall peptidoglycan. Proceedings of the National Academy of Sciences of the United States of America. 103: 4404-9. PMID 16537437 DOI: 10.1073/Pnas.0510182103 |
0.33 |
|
| 2006 |
Murray JB, Meroueh SO, Russell RJ, Lentzen G, Haddad J, Mobashery S. Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site. Chemistry & Biology. 13: 129-38. PMID 16492561 DOI: 10.1016/J.Chembiol.2005.11.004 |
0.343 |
|
| 2006 |
Fuda C, Hesek D, Lee M, Heilmayer W, Novak R, Vakulenko SB, Mobashery S. Mechanistic basis for the action of new cephalosporin antibiotics effective against methicillin- and vancomycin-resistant Staphylococcus aureus Journal of Biological Chemistry. 281: 10035-10041. PMID 16459335 DOI: 10.1074/Jbc.M508846200 |
0.809 |
|
| 2006 |
Kim C, Cha JY, Yan H, Vakulenko SB, Mobashery S. Hydrolysis of ATP by aminoglycoside 3'-phosphotransferases: an unexpected cost to bacteria for harboring an antibiotic resistance enzyme. The Journal of Biological Chemistry. 281: 6964-9. PMID 16407230 DOI: 10.1074/Jbc.M513257200 |
0.697 |
|
| 2006 |
Bonfil RD, Sabbota A, Nabha S, Bernardo MM, Dong Z, Meng H, Yamamoto H, Chinni SR, Lim IT, Chang M, Filetti LC, Mobashery S, Cher ML, Fridman R. Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor. International Journal of Cancer. Journal International Du Cancer. 118: 2721-6. PMID 16381009 DOI: 10.1002/Ijc.21645 |
0.456 |
|
| 2005 |
Cross JB, Vreven T, Meroueh SO, Mobashery S, Schlegel HB. Computational investigation of irreversible inactivation of the zinc-dependent protease carboxypeptidase A. The Journal of Physical Chemistry. B. 109: 4761-9. PMID 16851559 DOI: 10.1021/Jp0455172 |
0.343 |
|
| 2005 |
Meroueh SO, Fisher JF, Schlegel HB, Mobashery S. Ab initio QM/MM study of class A beta-lactamase acylation: dual participation of Glu166 and Lys73 in a concerted base promotion of Ser70. Journal of the American Chemical Society. 127: 15397-407. PMID 16262403 DOI: 10.1021/Ja051592U |
0.356 |
|
| 2005 |
Lee M, Bernardo MM, Meroueh SO, Brown S, Fridman R, Mobashery S. Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors Organic Letters. 7: 4463-4465. PMID 16178559 DOI: 10.1021/Ol0517269 |
0.302 |
|
| 2005 |
Fuda CC, Fisher JF, Mobashery S. Beta-lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome. Cellular and Molecular Life Sciences : Cmls. 62: 2617-33. PMID 16143832 DOI: 10.1007/S00018-005-5148-6 |
0.807 |
|
| 2005 |
Li J, Cross JB, Vreven T, Meroueh SO, Mobashery S, Schlegel HB. Lysine carboxylation in proteins: OXA-10 beta-lactamase. Proteins. 61: 246-57. PMID 16121396 DOI: 10.1002/Prot.20596 |
0.353 |
|
| 2005 |
Ikejiri M, Bernardo MM, Bonfil RD, Toth M, Chang M, Fridman R, Mobashery S. Potent mechanism-based inhibitors for matrix metalloproteinases. The Journal of Biological Chemistry. 280: 33992-4002. PMID 16046398 DOI: 10.1074/Jbc.M504303200 |
0.526 |
|
| 2005 |
Ikejiri M, Bernardo MM, Meroueh SO, Brown S, Chang M, Fridman R, Mobashery S. Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A. The Journal of Organic Chemistry. 70: 5709-12. PMID 15989356 DOI: 10.1021/Jo050339+ |
0.514 |
|
| 2005 |
Thomas VL, Golemi-Kotra D, Kim C, Vakulenko SB, Mobashery S, Shoichet BK. Structural consequences of the inhibitor-resistant Ser130Gly substitution in TEM beta-lactamase. Biochemistry. 44: 9330-8. PMID 15981999 DOI: 10.1021/Bi0502700 |
0.609 |
|
| 2005 |
Osenkowski P, Meroueh SO, Pavel D, Mobashery S, Fridman R. Mutational and structural analyses of the hinge region of membrane type 1-matrix metalloproteinase and enzyme processing Journal of Biological Chemistry. 280: 26160-26168. PMID 15901740 DOI: 10.1074/Jbc.M414379200 |
0.316 |
|
| 2005 |
Kim C, Mobashery S. Phosphoryl transfer by aminoglycoside 3'-phosphotransferases and manifestation of antibiotic resistance. Bioorganic Chemistry. 33: 149-58. PMID 15888308 DOI: 10.1016/J.Bioorg.2004.11.001 |
0.6 |
|
| 2005 |
Krüger A, Arlt MJ, Gerg M, Kopitz C, Bernardo MM, Chang M, Mobashery S, Fridman R. Antimetastatic activity of a novel mechanism-based gelatinase inhibitor. Cancer Research. 65: 3523-6. PMID 15867341 DOI: 10.1158/0008-5472.Can-04-3570 |
0.507 |
|
| 2005 |
Fuda C, Hesek D, Lee M, Morio KI, Nowak T, Mobashery S. Activation for catalysis of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by bacterial cell wall Journal of the American Chemical Society. 127: 2056-2057. PMID 15713078 DOI: 10.1021/Ja0434376 |
0.814 |
|
| 2005 |
Fisher JF, Meroueh SO, Mobashery S. Bacterial resistance to β-lactam antibiotics: Compelling opportunism, compelling opportunity Chemical Reviews. 105: 395-424. PMID 15700950 DOI: 10.1021/Cr030102I |
0.391 |
|
| 2005 |
Lee M, Hesek D, Mobashery S. A practical synthesis of nitrocefin Journal of Organic Chemistry. 70: 367-369. PMID 15624952 DOI: 10.1021/Jo0487395 |
0.386 |
|
| 2005 |
Toth M, Osenkowski P, Hesek D, Brown S, Meroueh S, Sakr W, Mobashery S, Fridman R. Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase Biochemical Journal. 387: 497-506. PMID 15560752 DOI: 10.1042/Bj20041324 |
0.314 |
|
| 2004 |
Birck C, Cha JY, Cross J, Schulze-Briese C, Meroueh SO, Schlegel HB, Mobashery S, Samama JP. X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction. Journal of the American Chemical Society. 126: 13945-7. PMID 15506754 DOI: 10.1021/Ja044742U |
0.587 |
|
| 2004 |
Lee M, Fridman R, Mobashery S. Extracellular proteases as targets for treatment of cancer metastases Chemical Society Reviews. 33: 401-409. PMID 15354221 DOI: 10.1039/B209224G |
0.331 |
|
| 2004 |
Brown S, Meroueh SO, Fridman R, Mobashery S. Quest for selectivity in inhibition of matrix metalloproteinases Current Topics in Medicinal Chemistry. 4: 1227-1238. PMID 15320723 DOI: 10.2174/1568026043387854 |
0.326 |
|
| 2004 |
Lim IT, Meroueh SO, Lee M, Heeg MJ, Mobashery S. Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis Journal of the American Chemical Society. 126: 10271-10277. PMID 15315439 DOI: 10.1021/Ja0489240 |
0.315 |
|
| 2004 |
Fuda C, Suvorov M, Vakulenko SB, Mobashery S. The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus. The Journal of Biological Chemistry. 279: 40802-6. PMID 15226303 DOI: 10.1074/Jbc.M403589200 |
0.816 |
|
| 2004 |
Golemi-Kotra D, Meroueh SO, Kim C, Vakulenko SB, Bulychev A, Stemmler AJ, Stemmler TL, Mobashery S. The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins. The Journal of Biological Chemistry. 279: 34665-73. PMID 15152012 DOI: 10.1074/Jbc.M313143200 |
0.608 |
|
| 2004 |
Solomon A, Rosenblum G, Gonzales PE, Leonard JD, Mobashery S, Milla ME, Sagi I. Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-α-converting enzyme and matrix metalloproteinases despite their high structural similarity Journal of Biological Chemistry. 279: 31646-31654. PMID 15102849 DOI: 10.1074/Jbc.M401310200 |
0.365 |
|
| 2004 |
Hesek D, Lee M, Morio KI, Mobashery S. Synthesis of a Fragment of Bacterial Cell Wall Journal of Organic Chemistry. 69: 2137-2146. PMID 15058963 DOI: 10.1021/Jo035583K |
0.314 |
|
| 2004 |
Kim C, Haddad J, Vakulenko SB, Meroueh SO, Wu Y, Yan H, Mobashery S. Fluorinated aminoglycosides and their mechanistic implication for aminoglycoside 3'-phosphotransferases from Gram-negative bacteria. Biochemistry. 43: 2373-83. PMID 14992574 DOI: 10.1021/Bi036095+ |
0.591 |
|
| 2004 |
Hesek D, Suvorov M, Morio K, Lee M, Brown S, Vakulenko SB, Mobashery S. Synthetic peptidoglycan substrates for penicillin-binding protein 5 of Gram-negative bacteria. The Journal of Organic Chemistry. 69: 778-84. PMID 14750804 DOI: 10.1021/Jo035397E |
0.737 |
|
| 2004 |
Cha JY, Ishiwata A, Mobashery S. A novel beta-lactamase activity from a penicillin-binding protein of Treponema pallidum and why syphilis is still treatable with penicillin. The Journal of Biological Chemistry. 279: 14917-21. PMID 14747460 DOI: 10.1074/Jbc.M400666200 |
0.6 |
|
| 2003 |
Lee M, Hesek D, Suvorov M, Lee W, Vakulenko S, Mobashery S. A mechanism-based inhibitor targeting the DD-transpeptidase activity of bacterial penicillin-binding proteins. Journal of the American Chemical Society. 125: 16322-6. PMID 14692773 DOI: 10.1021/Ja038445L |
0.748 |
|
| 2003 |
Meroueh SO, Minasov G, Lee W, Shoichet BK, Mobashery S. Structural aspects for evolution of beta-lactamases from penicillin-binding proteins. Journal of the American Chemical Society. 125: 9612-8. PMID 12904027 DOI: 10.1021/Ja034861U |
0.432 |
|
| 2003 |
Vakulenko SB, Mobashery S. Versatility of aminoglycosides and prospects for their future Clinical Microbiology Reviews. 16: 430-450. PMID 12857776 DOI: 10.1128/Cmr.16.3.430-450.2003 |
0.394 |
|
| 2003 |
Fridman R, Toth M, Chvyrkova I, Meroueh SO, Mobashery S. Cell surface association of matrix metalloproteinase-9 (gelatinase B) Cancer and Metastasis Reviews. 22: 153-166. PMID 12784994 DOI: 10.1023/A:1023091214123 |
0.318 |
|
| 2003 |
Rosenblum G, Meroueh SO, Kleifeld O, Brown S, Singson SP, Fridman R, Mobashery S, Sagi I. Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2) Journal of Biological Chemistry. 278: 27009-27015. PMID 12679334 DOI: 10.1074/Jbc.M301139200 |
0.357 |
|
| 2003 |
Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S. The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography. Journal of the American Chemical Society. 125: 3410-1. PMID 12643685 DOI: 10.1021/Ja029736H |
0.379 |
|
| 2003 |
Golemi-Kotra D, Cha JY, Meroueh SO, Vakulenko SB, Mobashery S. Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus. The Journal of Biological Chemistry. 278: 18419-25. PMID 12591921 DOI: 10.1074/Jbc.M300611200 |
0.597 |
|
| 2002 |
Kotra LP, Zhang L, Fridman R, Orlando R, Mobashery S. N-Glycosylation pattern of the zymogenic form of human matrix metalloproteinase-9. Bioorganic Chemistry. 30: 356-70. PMID 12485595 DOI: 10.1016/S0045-2068(02)00501-1 |
0.332 |
|
| 2002 |
Meroueh SO, Roblin P, Golemi D, Maveyraud L, Vakulenko SB, Zhang Y, Samama JP, Mobashery S. Molecular dynamics at the root of expansion of function in the M69L inhibitor-resistant TEM beta-lactamase from Escherichia coli. Journal of the American Chemical Society. 124: 9422-30. PMID 12167037 DOI: 10.1021/Ja026547Q |
0.433 |
|
| 2002 |
Vakulenko SB, Golemi D, Geryk B, Suvorov M, Knox JR, Mobashery S, Lerner SA. Mutational replacement of Leu-293 in the class C Enterobacter cloacae P99 beta-lactamase confers increased MIC of cefepime. Antimicrobial Agents and Chemotherapy. 46: 1966-70. PMID 12019116 DOI: 10.1128/Aac.46.6.1966-1970.2002 |
0.711 |
|
| 2002 |
Toth M, Hernandez-Barrantes S, Osenkowski P, Bernardo MM, Gervasi DC, Shimura Y, Meroueh O, Kotra LP, Gálvez BG, Arroyo AG, Mobashery S, Fridman R. Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzyme. The Journal of Biological Chemistry. 277: 26340-50. PMID 12004057 DOI: 10.1074/Jbc.M200655200 |
0.361 |
|
| 2002 |
Llano-Sotelo B, Azucena EF, Kotra LP, Mobashery S, Chow CS. Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site. Chemistry & Biology. 9: 455-63. PMID 11983334 DOI: 10.1016/S1074-5521(02)00125-4 |
0.393 |
|
| 2002 |
Haddad J, Kotra LP, Llano-Sotelo B, Kim C, Azucena EF, Liu M, Vakulenko SB, Chow CS, Mobashery S. Design of novel antibiotics that bind to the ribosomal acyltransfer site. Journal of the American Chemical Society. 124: 3229-37. PMID 11916405 DOI: 10.1021/Ja011695M |
0.599 |
|
| 2002 |
Maveyraud L, Golemi-Kotra D, Ishiwata A, Meroueh O, Mobashery S, Samama JP. High-resolution X-ray structure of an acyl-enzyme species for the class D OXA-10 beta-lactamase. Journal of the American Chemical Society. 124: 2461-5. PMID 11890794 DOI: 10.1021/Ja016736T |
0.378 |
|
| 2002 |
Bernardo MM, Brown S, Li ZH, Fridman R, Mobashery S. Design, synthesis, and characterization of potent, slow-binding inhibitors that are selective for gelatinases. The Journal of Biological Chemistry. 277: 11201-7. PMID 11790786 DOI: 10.1074/Jbc.M111021200 |
0.343 |
|
| 2002 |
Golemi D, Maveyraud L, Haddad J, Lee W, Ishiwata A, Miyashita K, Mourey L, Vakulenko S, Kotra L, Samama JP, Mobashery S. Antibacterials as wonder drugs and how their effectiveness is being compromised Pharmacochemistry Library. 32: 193-205. DOI: 10.1016/S0165-7208(02)80020-4 |
0.402 |
|
| 2001 |
Golemi D, Maveyraud L, Vakulenko S, Samama J, Mobashery S. Critical involvement of a carbamylated lysine in catalytic function of class D β-lactamases Proceedings of the National Academy of Sciences of the United States of America. 98: 14280-14285. PMID 11724923 DOI: 10.1073/Pnas.241442898 |
0.368 |
|
| 2001 |
Grapsas I, Lerner SA, Mobashery S. Conjoint molecules of cephalosporins and aminoglycosides. Archiv Der Pharmazie. 334: 295-301. PMID 11688141 DOI: 10.1002/1521-4184(200109)334:8/9<295::Aid-Ardp295>3.0.Co;2-3 |
0.346 |
|
| 2001 |
Azucena E, Mobashery S. Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition. Drug Resistance Updates. 4: 106-117. PMID 11512519 DOI: 10.1054/Drup.2001.0197 |
0.387 |
|
| 2001 |
Nagase T, Golemi D, Ishiwata A, Mobashery S. Inhibition of β-Lactamases by 6,6-Bis(hydroxylmethyl)penicillanate Bioorganic Chemistry. 29: 140-145. PMID 11437389 DOI: 10.1006/Bioo.2001.1205 |
0.387 |
|
| 2001 |
Kim DH, Mobashery S. Mechanism-Based Inhibition of Zinc Proteases Current Medicinal Chemistry. 8: 959-965. PMID 11375763 DOI: 10.2174/0929867013372805 |
0.337 |
|
| 2001 |
Kridel SJ, Chen E, Kotra LP, Howard EW, Mobashery S, Smith JW. Substrate hydrolysis by matrix metalloproteinase-9. The Journal of Biological Chemistry. 276: 20572-8. PMID 11279151 DOI: 10.1074/Jbc.M100900200 |
0.319 |
|
| 2001 |
Kleifeld O, Kotra LP, Gervasi DC, Brown S, Bernardo MM, Fridman R, Mobashery S, Sagi I. X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme. The Journal of Biological Chemistry. 276: 17125-31. PMID 11278946 DOI: 10.1074/Jbc.M011604200 |
0.364 |
|
| 2001 |
Lee W, McDonough MA, Kotra LP, Li ZH, Silvaggi NR, Takeda Y, Kelly JA, Mobashery S. A 1.2-Å snapshot of the final step of bacterial cell wall biosynthesis Proceedings of the National Academy of Sciences of the United States of America. 98: 1427-1431. PMID 11171967 DOI: 10.1073/Pnas.98.4.1427 |
0.395 |
|
| 2000 |
Maveyraud L, Golemi D, Kotra LP, Tranier S, Vakulenko S, Mobashery S, Samama J. Insights into Class D β-Lactamases Are Revealed by the Crystal Structure of the OXA10 Enzyme from Pseudomonas aeruginosa Structure. 8: 1289-1298. PMID 11188693 DOI: 10.1016/S0969-2126(00)00534-7 |
0.37 |
|
| 2000 |
Golemi D, Maveyraud L, Ishiwata A, Tranier S, Miyashita K, Nagase T, Massova I, Mourey L, Samama J, Mobashery S. 6-(Hydroxyalkyl)penicillanates as Probes for Mechanisms of β-Lactamases The Journal of Antibiotics. 53: 1022-1027. PMID 11132946 DOI: 10.7164/Antibiotics.53.1022 |
0.331 |
|
| 2000 |
Kotra LP, Haddad J, Mobashery S. Aminoglycosides: Perspectives on Mechanisms of Action and Resistance and Strategies to Counter Resistance Antimicrobial Agents and Chemotherapy. 44: 3249-3256. PMID 11083623 DOI: 10.1128/Aac.44.12.3249-3256.2000 |
0.379 |
|
| 2000 |
Liu M, Haddad J, Azucena E, Kotra LP, Kirzhner M, Mobashery S. Tethered bisubstrate derivatives as probes for mechanism and as inhibitors of aminoglycoside 3'-phosphotransferases. Journal of Organic Chemistry. 65: 7422-7431. PMID 11076599 DOI: 10.1021/Jo000589K |
0.385 |
|
| 2000 |
Therrien C, Kotra LP, Sanschagrin F, Mobashery S, Levesque RC. Evaluation of inhibition of the carbenicillin-hydrolyzing beta-lactamase PSE-4 by the clinically used mechanism-based inhibitors. Febs Letters. 470: 285-92. PMID 10745083 DOI: 10.1016/S0014-5793(00)01342-9 |
0.383 |
|
| 2000 |
Olson MW, Bernardo MM, Pietila M, Gervasi DC, Toth M, Kotra LP, Massova I, Mobashery S, Fridman R. Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. Differential rates for activation by stromelysin 1. The Journal of Biological Chemistry. 275: 2661-8. PMID 10644727 DOI: 10.1074/Jbc.275.4.2661 |
0.344 |
|
| 2000 |
Lee W, Li ZH, Vakulenko S, Mobashery S. A light-inactivated antibiotic. Journal of Medicinal Chemistry. 43: 128-32. PMID 10633044 DOI: 10.1021/Jm980648A |
0.341 |
|
| 2000 |
Golemi D, Maveyraud L, Vakulenko S, Tranier S, Ishiwata A, Kotra LP, Samama J, Mobashery S. The First Structural and Mechanistic Insights for Class D beta-Lactamases: Evidence for a Novel Catalytic Process for Turnover of beta-Lactam Antibiotics Journal of the American Chemical Society. 122: 6132-6133. DOI: 10.2210/Pdb1Ewz/Pdb |
0.343 |
|
| 2000 |
Bulychev A, Bellettini JR, O'Brien M, Crocker PJ, Samama J, Miller MJ, Mobashery S. N-Sulfonyloxy-β-lactam Inhibitors for β-Lactamases Tetrahedron. 56: 5719-5728. DOI: 10.1016/S0040-4020(00)00427-0 |
0.363 |
|
| 1999 |
Mourey L, Kotra LP, Bellettini J, Bulychev A, O'Brien M, Miller MJ, Mobashery S, Samama JP. Inhibition of the broad spectrum nonmetallocarbapenamase of class A (NMC-A) beta-lactamase from Enterobacter cloacae by monocyclic beta-lactams. The Journal of Biological Chemistry. 274: 25260-5. PMID 10464248 DOI: 10.1074/Jbc.274.36.25260 |
0.395 |
|
| 1999 |
Vakulenko SB, Taibi-Tronche P, Tóth M, Massova I, Lerner SA, Mobashery S. Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) beta-lactamase from Escherichia coli. The Journal of Biological Chemistry. 274: 23052-60. PMID 10438473 DOI: 10.1074/Jbc.274.33.23052 |
0.371 |
|
| 1999 |
Swarén P, Golemi D, Cabantous S, Bulychev A, Maveyraud L, Mobashery S, Samama JP. X-ray structure of the Asn276Asp variant of the Escherichia coli TEM-1 beta-lactamase: direct observation of electrostatic modulation in resistance to inactivation by clavulanic acid. Biochemistry. 38: 9570-6. PMID 10423234 DOI: 10.1021/Bi990758Z |
0.405 |
|
| 1999 |
Bulychev A, Mobashery S. Class C β-Lactamases Operate at the Diffusion Limit for Turnover of Their Preferred Cephalosporin Substrates Antimicrobial Agents and Chemotherapy. 43: 1743-1746. PMID 10390233 DOI: 10.1128/Aac.43.7.1743 |
0.335 |
|
| 1999 |
Haddad J, Vakulenko aS, Mobashery S. An Antibiotic Cloaked by Its Own Resistance Enzyme Journal of the American Chemical Society. 121: 11922-11923. DOI: 10.1021/Ja993452O |
0.414 |
|
| 1998 |
Yang Y, Roestamadji J, Mobashery S, Orlando R. The use of neamine as a molecular template: Identification of active site residues in the bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa by mass spectroscopy Bioorganic and Medicinal Chemistry Letters. 8: 3489-3494. PMID 9934458 DOI: 10.1016/S0960-894X(98)00634-9 |
0.396 |
|
| 1998 |
Roestamadji J, Mobashery S. The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa. Bioorganic & Medicinal Chemistry Letters. 8: 3483-3488. PMID 9934457 DOI: 10.1016/S0960-894X(98)00633-7 |
0.432 |
|
| 1998 |
Massova I, Martin P, Bulychev A, Kocz R, Doyle M, Edwards BF, Mobashery S. Templates for design of inhibitors for serine proteases: application of the program DOCK to the discovery of novel inhibitors for thrombin. Bioorganic & Medicinal Chemistry Letters. 8: 2463-6. PMID 9873562 DOI: 10.1016/S0960-894X(98)00444-2 |
0.311 |
|
| 1998 |
Vakulenko SB, Geryk B, Kotra LP, Mobashery S, Lerner SA. Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene. Antimicrobial Agents and Chemotherapy. 42: 1542-8. PMID 9660980 DOI: 10.1128/Aac.42.7.1542 |
0.392 |
|
| 1998 |
Massova I, Mobashery S. Kinship and Diversification of Bacterial Penicillin-Binding Proteins and β-Lactamases Antimicrobial Agents and Chemotherapy. 42: 1-17. PMID 9449253 DOI: 10.1128/Aac.42.1.1 |
0.349 |
|
| 1998 |
Massova I, Kotra LP, Fridman R, Mobashery S. Matrix metalloproteinases: structures, evolution, and diversification The Faseb Journal. 12: 1075-1095. DOI: 10.1096/Fasebj.12.12.1075 |
0.313 |
|
| 1998 |
Li Z, Bulychev A, Kotra LP, Massova I, Mobashery S. Hydrogen Bonding and Attenuation of the Rate of Enzymic Catalysis Journal of the American Chemical Society. 120: 13003-13007. DOI: 10.1021/Ja983063E |
0.302 |
|
| 1998 |
Maveyraud L, Mourey L, Kotra LP, Pedelacq J, Guillet V, Mobashery S, Samama J. Structural Basis for Clinical Longevity of Carbapenem Antibiotics in the Face of Challenge by the Common Class A β-Lactamases from the Antibiotic-Resistant Bacteria Journal of the American Chemical Society. 120: 9748-9752. DOI: 10.1021/Ja9818001 |
0.42 |
|
| 1998 |
Mourey L, Miyashita K, Swarén P, Bulychev A, Samama J, Mobashery S. Inhibition of the NMC-A β-Lactamase by a Penicillanic Acid Derivative and the Structural Bases for the Increase in Substrate Profile of This Antibiotic Resistance Enzyme Journal of the American Chemical Society. 120: 9382-9383. DOI: 10.1021/Ja9817996 |
0.419 |
|
| 1998 |
Kotra LP, Mobashery S. β-Lactam antibiotics, β-lactamases and bacterial resistance Bulletin De L'Institut Pasteur. 96: 139-150. DOI: 10.1016/S0020-2452(98)80009-2 |
0.368 |
|
| 1998 |
Bush K, Mobashery S. How β-Lactamases Have Driven Pharmaceutical Drug Discovery Advances in Experimental Medicine and Biology. 456: 71-98. DOI: 10.1007/978-1-4615-4897-3_5 |
0.398 |
|
| 1997 |
Olson MW, Gervasi DC, Mobashery S, Fridman R. Kinetic analysis of the binding of human matrix metalloproteinase-2 and -9 to tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2. The Journal of Biological Chemistry. 272: 29975-83. PMID 9368077 DOI: 10.1074/Jbc.272.47.29975 |
0.355 |
|
| 1997 |
Azucena E, Grapsas I, Mobashery S. Properties of a Bifunctional Bacterial Antibiotic Resistance Enzyme That Catalyzes ATP-Dependent 2‘‘-Phosphorylation and Acetyl-CoA-Dependent 6‘-Acetylation of Aminoglycosides Journal of the American Chemical Society. 119: 2317-2318. DOI: 10.1021/Ja964278W |
0.397 |
|
| 1997 |
Bulychev A, Massova I, Miyashita K, Mobashery S. Nuances of Mechanisms and Their Implications for Evolution of the Versatile β-Lactamase Activity: From Biosynthetic Enzymes to Drug Resistance Factors Journal of the American Chemical Society. 119: 7619-7625. DOI: 10.1021/Ja963708F |
0.383 |
|
| 1997 |
Massova I, Pirkle H, Edwards BF, Mobashery S. Insights into the three-dimensional structure of crotalase: Implications for biological activity and substrate specificity Bioorganic & Medicinal Chemistry Letters. 7: 3139-3144. DOI: 10.1016/S0960-894X(97)10168-8 |
0.316 |
|
| 1997 |
Massova I, Fridman R, Mobashery S. Structural Insights into the Catalytic Domains of Human Matrix Metalloprotease-2 and Human Matrix Metalloprotease-9: Implications for Substrate Specificities Journal of Molecular Modeling. 3: 17-30. DOI: 10.1007/S008940050021 |
0.324 |
|
| 1996 |
Ghosh SS, Dakoji S, Tanaka Y, Cho YJ, Mobashery S. Properties of analogues of an intermediate in the process of mechanism-based inactivation of carboxypeptidase A. Bioorganic & Medicinal Chemistry. 4: 1487-92. PMID 8894106 DOI: 10.1016/0968-0896(96)00142-3 |
0.334 |
|
| 1996 |
Maveyraud L, Massova I, Birck C, Miyashita K, Samama J, Mobashery S. Crystal Structure of 6α-(Hydroxymethyl)penicillanate Complexed to the TEM-1 β-Lactamase from Escherichia coli: Evidence on the Mechanism of Action of a Novel Inhibitor Designed by a Computer-Aided Process Journal of the American Chemical Society. 118: 7435-7440. DOI: 10.1021/Ja9609718 |
0.38 |
|
| 1996 |
Taibi-Tronche P, Massova I, Vakulenko SB, Lerner SA, Mobashery S. Evidence for structural elasticity of class A β-lactamases in the course of catalytic turnover of the novel cephalosporin cefepime Journal of the American Chemical Society. 118: 7441-7448. DOI: 10.1021/Ja9529753 |
0.379 |
|
| 1996 |
Miyashita K, Massova I, Mobashery S. Quantification of the extent of attenuation of the rate of turnover chemistry of the TEM-1 β-lactamase by the α-1R-hydroxyethyl group in substrates Bioorganic & Medicinal Chemistry Letters. 6: 319-322. DOI: 10.1016/0960-894X(96)00022-4 |
0.305 |
|
| 1995 |
Siregar JJ, Miroshnikov K, Mobashery S. Purification, characterization, and investigation of the mechanism of aminoglycoside 3'-phosphotransferase type Ia. Biochemistry. 34: 12681-12688. PMID 7548020 DOI: 10.1021/Bi00039A026 |
0.384 |
|
| 1995 |
Vakulenko SB, Tóth M, Taibi P, Mobashery S, Lerner SA. Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams. Antimicrobial Agents and Chemotherapy. 39: 1878-80. PMID 7486939 DOI: 10.1128/Aac.39.8.1878 |
0.369 |
|
| 1995 |
Roestamadji J, Grapsas I, Mobashery S. Loss of individual electrostatic interactions between aminoglycoside antibiotics and resistance enzymes as an effective means to overcoming bacterial drug resistance Journal of the American Chemical Society. 117: 11060-11069. DOI: 10.1021/Ja00150A004 |
0.39 |
|
| 1995 |
Miyashita K, Massova I, Taibi P, Mobashery S. Design, Synthesis, and Evaluation of a Potent Mechanism-Based Inhibitor for the TEM .beta.-Lactamase with Implications for the Enzyme Mechanism Journal of the American Chemical Society. 117: 11055-11059. DOI: 10.1021/Ja00150A003 |
0.353 |
|
| 1995 |
Bulychev A, O'Brien ME, Massova I, Teng M, Gibson TA, Miller MJ, Mobashery S. Potent mechanism-based inhibition of the TEM-1 .beta.-lactamase by novel N-sulfonyloxy .beta.-lactams Journal of the American Chemical Society. 117: 5938-5943. DOI: 10.1021/Ja00127A005 |
0.31 |
|
| 1995 |
Roestamadji J, Grapsas I, Mobashery S. Mechanism-Based Inactivation Of Bacterial Aminoglycoside 3'-Phosphotransferases Journal of the American Chemical Society. 117: 80-84. DOI: 10.1021/Ja00106A009 |
0.3 |
|
| 1995 |
Miyashita K, Mobashery S. Mechanistic support for the stepwise process for inactivation of class A β-lactamases by clavulanate Bioorganic & Medicinal Chemistry Letters. 5: 1043-1048. DOI: 10.1016/0960-894X(95)00162-M |
0.34 |
|
| 1994 |
Imtiaz U, Billings EM, Knox JR, Mobashery S. A structure-based analysis of the inhibition of class A beta-lactamases by sulbactam. Biochemistry. 33: 5728-5738. PMID 8180199 DOI: 10.1021/Bi00185A009 |
0.35 |
|
| 1994 |
Siregar JJ, Lerner SA, Mobashery S. Purification and characterization of aminoglycoside 3'-phosphotransferase type IIa and kinetic comparison with a new mutant enzyme. Antimicrobial Agents and Chemotherapy. 38: 641-7. PMID 8031025 DOI: 10.1128/Aac.38.4.641 |
0.369 |
|
| 1993 |
Levy OE, Taibi P, Mobashery S, Ghosh SS. A mechanism-based inactivation study of neutral endopeptidase 24.11. Journal of Medicinal Chemistry. 36: 2408-11. PMID 8360886 DOI: 10.1021/Jm00068A019 |
0.336 |
|
| 1993 |
Imtiaz U, Manavathu EK, Lerner SA, Mobashery S. Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase. Antimicrobial Agents and Chemotherapy. 37: 2438-42. PMID 8285630 DOI: 10.1128/Aac.37.11.2438 |
0.353 |
|
| 1993 |
Zafaralla G, Mobashery S. Evidence for a new enzyme-catalyzed reaction other than .beta.-lactam hydrolysis in turnover of a penem by the TEM-1 .beta.-lactamase Journal of the American Chemical Society. 115: 4962-4965. DOI: 10.1021/Ja00065A003 |
0.346 |
|
| 1993 |
Imtiaz U, Billings E, Knox JR, Manavathu EK, Lerner SA, Mobashery S. Inactivation of class A β-lactamases by clavulanic acid : the role of arginine-244 in a proposed nonconcerted sequence of events Journal of the American Chemical Society. 115: 4435-4442. DOI: 10.1021/Ja00064A003 |
0.343 |
|
| 1992 |
Zafaralla G, Manavathu EK, Lerner SA, Mobashery S. Elucidation of the role of arginine-244 in the turnover processes of class A beta-lactamases. Biochemistry. 31: 3847-52. PMID 1567841 DOI: 10.1021/Bi00130A016 |
0.349 |
|
| 1992 |
Ghosh SS, Said-Nejad O, Roestamadji J, Mobashery S. The first mechanism-based inactivators for angiotensin-converting enzyme. Journal of Medicinal Chemistry. 35: 4175-9. PMID 1331459 DOI: 10.1021/Jm00100A024 |
0.328 |
|
| 1992 |
Zafaralla G, Mobashery S. Facilitation of the .DELTA.2 .fwdarw. .DELTA.1 pyrroline tautomerization of carbapenem antibiotics by the highly conserved arginine-244 of class A .beta.-lactamases during the course of turnover Journal of the American Chemical Society. 114: 1505-1506. DOI: 10.1021/Ja00030A070 |
0.351 |
|
| 1990 |
Mobashery S, Doughty M, Kaiser ET. Inactivation of the catalytic subunit of bovine cAMP-dependent protein kinase by a peptide-based affinity inactivator. Biopolymers. 29: 131-8. PMID 2328282 DOI: 10.1002/Bip.360290118 |
0.651 |
|
| 1990 |
Mobashery S, Ghosh SS, Tamura SY, Kaiser ET. Design of an effective mechanism-based inactivator for a zinc protease. Proceedings of the National Academy of Sciences of the United States of America. 87: 578-82. PMID 2300547 DOI: 10.1073/Pnas.87.2.578 |
0.555 |
|
| 1989 |
Radziejewski C, Miller WT, Mobashery S, Goldberg AR, Kaiser ET. Purification of recombinant pp60v-src protein tyrosine kinase and phosphorylation of peptides with different secondary structure preference. Biochemistry. 28: 9047-52. PMID 2481500 |
0.529 |
|
| 1988 |
Mobashery S, Kaiser ET. Identification of amino acid residues involved in substrate recognition by the catalytic subunit of bovine cyclic AMP dependent protein kinase: peptide-based affinity labels. Biochemistry. 27: 3691-6. PMID 3408721 DOI: 10.1021/Bi00410A025 |
0.461 |
|
| 1986 |
Mobashery S, Johnston M. Preparation of ceph-3-em esters unaccompanied by .DELTA.3 .fwdarw. .DELTA.2 isomerization of the cephalosporin The Journal of Organic Chemistry. 51: 4723-4726. DOI: 10.1021/Jo00374A045 |
0.508 |
|
| 1986 |
Mobashery S, Lerner SA, Johnston M. Conscripting β-Lactamase for Use in Drug Delivery. Synthesis and Biological Activity of a Cephalosporin C10-Ester of an Antibiotic Dipeptide. Journal of the American Chemical Society. 108: 1685-1686. DOI: 10.1021/Ja00267A045 |
0.563 |
|
| 1986 |
Mobashery S, Johnston M. A novel approach to deacylation of ceph-3-em esters Tetrahedron Letters. 27: 3333-3336. DOI: 10.1016/S0040-4039(00)84788-7 |
0.513 |
|
| 1985 |
Mobashery S, Johnston M. A new approach to the preparation of N-carboxy .alpha.-amino acid anhydrides The Journal of Organic Chemistry. 50: 2200-2202. DOI: 10.1021/Jo00212A042 |
0.506 |
|
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