| Year |
Citation |
Score |
| 2020 |
Wilson MM, Weinberg RA, Lees JA, Guen VJ. Emerging Mechanisms by which EMT Programs Control Stemness. Trends in Cancer. PMID 32312682 DOI: 10.1016/J.Trecan.2020.03.011 |
0.312 |
|
| 2020 |
Sharma S, Zhang T, Michowski W, Rebecca VW, Xiao M, Ferretti R, Suski JM, Bronson RT, Paulo JA, Frederick D, Fassl A, Boland GM, Geng Y, Lees JA, Medema RH, et al. Targeting the cyclin-dependent kinase 5 in metastatic melanoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 32193336 DOI: 10.1073/Pnas.1912617117 |
0.376 |
|
| 2019 |
Dalin S, Sullivan MR, Lau AN, Grauman-Boss B, Mueller HS, Kreidl E, Fenoglio S, Luengo A, Lees JA, Vander Heiden MG, Lauffenburger DA, Hemann MT. Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance. Cancer Research. PMID 31484670 DOI: 10.1158/0008-5472.Can-19-0960 |
0.307 |
|
| 2019 |
Ning JF, Stanciu M, Humphrey MR, Gorham J, Wakimoto H, Nishihara R, Lees J, Zou L, Martuza RL, Wakimoto H, Rabkin SD. Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma. Nature Communications. 10: 2910. PMID 31266951 DOI: 10.1038/S41467-019-10993-5 |
0.411 |
|
| 2018 |
Parisi T, Balsamo M, Gertler F, Lees JA. The Rb tumor suppressor regulates epithelial cell migration and polarity. Molecular Carcinogenesis. PMID 30084175 DOI: 10.1002/Mc.22886 |
0.404 |
|
| 2018 |
Perez DE, Henle AM, Amsterdam A, Hagen HR, Lees JA. Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology. Pigment Cell & Melanoma Research. PMID 29570931 DOI: 10.1111/Pcmr.12700 |
0.359 |
|
| 2018 |
Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli M, Sánchez-Rivera F, Park Y, Liang X, Eng G, Taylor MS, Azimi R, ... ... Lees J, et al. Abstract B38: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis Cancer Research. 78. DOI: 10.1158/1538-7445.Mousemodels17-B38 |
0.339 |
|
| 2017 |
Guen VJ, Chavarria TE, Kröger C, Ye X, Weinberg RA, Lees JA. EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 29158396 DOI: 10.1073/Pnas.1711534114 |
0.345 |
|
| 2017 |
Guen VJ, Edvardson S, Fraenkel ND, Fattal-Valevski A, Jalas C, Anteby I, Shaag A, Dor T, Gillis D, Kerem E, Lees JA, Colas P, Elpeleg O. A homozygous deleterious CDK10 mutation in a patient with agenesis of corpus callosum, retinopathy, and deafness. American Journal of Medical Genetics. Part A. PMID 29130579 DOI: 10.1002/Ajmg.A.38506 |
0.417 |
|
| 2017 |
Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA. Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma. Cancer Cell. PMID 28966034 DOI: 10.1016/J.Ccell.2017.08.018 |
0.452 |
|
| 2017 |
Mori M, Hazan R, Danielian PS, Mahoney JE, Li H, Lu J, Miller ES, Zhu X, Lees JA, Cardoso WV. Cytoplasmic E2f4 forms organizing centres for initiation of centriole amplification during multiciliogenesis. Nature Communications. 8: 15857. PMID 28675157 DOI: 10.1038/Ncomms15857 |
0.395 |
|
| 2017 |
Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, ... ... Lees J, et al. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nature Biotechnology. PMID 28459449 DOI: 10.1038/Nbt.3836 |
0.359 |
|
| 2017 |
Guen VJ, Gamble C, Lees JA, Colas P. The awakening of the CDK10/Cyclin M protein kinase. Oncotarget. PMID 28178678 DOI: 10.18632/Oncotarget.15024 |
0.397 |
|
| 2016 |
Guen VJ, Gamble C, Perez DE, Bourassa S, Zappel H, Gärtner J, Lees JA, Colas P. STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis. Cell Cycle (Georgetown, Tex.). 15: 678-88. PMID 27104747 DOI: 10.1080/15384101.2016.1147632 |
0.382 |
|
| 2016 |
Danielian PS, Hess RA, Lees JA. E2f4 and E2f5 are essential for the development of the male reproductive system. Cell Cycle (Georgetown, Tex.). 15: 250-60. PMID 26825228 DOI: 10.1080/15384101.2015.1121350 |
0.383 |
|
| 2016 |
Ferretti R, Bhutkar A, McNamara MC, Lees JA. BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance. Genes & Development. 30: 18-33. PMID 26679841 DOI: 10.1101/Gad.267757.115 |
0.359 |
|
| 2016 |
Nicolay BN, Danielian PS, Kottakis F, Lapek JD, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, et al. Abstract IA15: The consequences of pRb inactivation: insights from a proteomic analysis of Rb loss Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Cellcycle16-Ia15 |
0.447 |
|
| 2015 |
Nicolay BN, Danielian PS, Kottakis F, Lapek JD, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, et al. Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation. Genes & Development. 29: 1875-89. PMID 26314710 DOI: 10.1101/Gad.264127.115 |
0.368 |
|
| 2015 |
Percival SM, Thomas HR, Amsterdam A, Carroll AJ, Lees JA, Yost HJ, Parant JM. Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome. Disease Models & Mechanisms. 8: 941-55. PMID 26044958 DOI: 10.1242/Dmm.019059 |
0.382 |
|
| 2015 |
McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD. Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide. Cancer Research. PMID 26025730 DOI: 10.1158/0008-5472.Can-14-3616 |
0.351 |
|
| 2015 |
Parisi T, Bronson RT, Lees JA. Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer. Oncogene. PMID 25745996 DOI: 10.1038/Onc.2015.30 |
0.364 |
|
| 2014 |
Maynard MA, Ferretti R, Hilgendorf KI, Perret C, Whyte P, Lees JA. Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer. Oncogene. 33: 3742-7. PMID 23955081 DOI: 10.1038/Onc.2013.333 |
0.368 |
|
| 2014 |
Nicolay BN, Danielian PS, Haas W, Stephanopoulos G, Lees JA, Dyson NJ. Metabolic analysis of the loss of Rb1 in vivo Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-O4 |
0.361 |
|
| 2013 |
Zhang G, Hoersch S, Amsterdam A, Whittaker CA, Beert E, Catchen JM, Farrington S, Postlethwait JH, Legius E, Hopkins N, Lees JA. Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery. Plos Genetics. 9: e1003734. PMID 24009526 DOI: 10.1371/Journal.Pgen.1003734 |
0.638 |
|
| 2013 |
Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA. The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes & Development. 27: 1003-15. PMID 23618872 DOI: 10.1101/Gad.211326.112 |
0.395 |
|
| 2013 |
Landman AS, Danielian PS, Lees JA. Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation. Oncogene. 32: 4798-805. PMID 23146901 DOI: 10.1038/Onc.2012.496 |
0.428 |
|
| 2013 |
Ferretti R, Lees JA. Abstract C11: Molecular mechanism driving BMI1-induced melanoma metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-C11 |
0.411 |
|
| 2012 |
Ravi A, Gurtan AM, Kumar MS, Bhutkar A, Chin C, Lu V, Lees JA, Jacks T, Sharp PA. Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1. Cancer Cell. 21: 848-55. PMID 22698408 DOI: 10.1016/J.Ccr.2012.04.037 |
0.347 |
|
| 2012 |
Itzkovitz S, Lyubimova A, Blat IC, Maynard M, van Es J, Lees J, Jacks T, Clevers H, van Oudenaarden A. Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nature Cell Biology. 14: 106-14. PMID 22119784 DOI: 10.1038/Ncb2384 |
0.321 |
|
| 2010 |
Zhang G, Hoersch S, Amsterdam A, Whittaker CA, Lees JA, Hopkins N. Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proceedings of the National Academy of Sciences of the United States of America. 107: 16940-5. PMID 20837522 DOI: 10.1073/Pnas.1011548107 |
0.654 |
|
| 2010 |
Calo E, Quintero-Estades JA, Danielian PS, Nedelcu S, Berman SD, Lees JA. Rb regulates fate choice and lineage commitment in vivo. Nature. 466: 1110-4. PMID 20686481 DOI: 10.1038/Nature09264 |
0.475 |
|
| 2010 |
Miller ES, Berman SD, Yuan TL, Lees JA. Disruption of calvarial ossification in E2f4 mutant embryos correlates with increased proliferation and progenitor cell populations. Cell Cycle (Georgetown, Tex.). 9: 2620-8. PMID 20581455 DOI: 10.4161/Cc.9.13.12108 |
0.466 |
|
| 2010 |
Sansam CL, Cruz NM, Danielian PS, Amsterdam A, Lau ML, Hopkins N, Lees JA. A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes & Development. 24: 183-94. PMID 20080954 DOI: 10.1101/Gad.1860310 |
0.76 |
|
| 2010 |
Zhang J, Lee EY, Liu Y, Berman SD, Lodish HF, Lees JA. pRB and E2F4 play distinct cell-intrinsic roles in fetal erythropoiesis. Cell Cycle (Georgetown, Tex.). 9: 371-6. PMID 20023434 DOI: 10.4161/Cc.9.2.10467 |
0.475 |
|
| 2009 |
Berman SD, West JC, Danielian PS, Caron AM, Stone JR, Lees JA. Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proceedings of the National Academy of Sciences of the United States of America. 106: 14932-6. PMID 19706423 DOI: 10.1073/Pnas.0902408106 |
0.438 |
|
| 2009 |
Amsterdam A, Lai K, Komisarczuk AZ, Becker TS, Bronson RT, Hopkins N, Lees JA. Zebrafish Hagoromo mutants up-regulate fgf8 postembryonically and develop neuroblastoma. Molecular Cancer Research : McR. 7: 841-50. PMID 19531571 DOI: 10.1158/1541-7786.Mcr-08-0555 |
0.663 |
|
| 2009 |
Lee EY, Yuan TL, Danielian PS, West JC, Lees JA. E2F4 cooperates with pRB in the development of extra-embryonic tissues. Developmental Biology. 332: 104-15. PMID 19433082 DOI: 10.1016/J.Ydbio.2009.05.541 |
0.425 |
|
| 2009 |
Ianari A, Natale T, Calo E, Ferretti E, Alesse E, Screpanti I, Haigis K, Gulino A, Lees JA. Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell. 15: 184-94. PMID 19249677 DOI: 10.1016/J.Ccr.2009.01.026 |
0.483 |
|
| 2009 |
Lai K, Amsterdam A, Farrington S, Bronson RT, Hopkins N, Lees JA. Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 76-85. PMID 19097187 DOI: 10.1002/Dvdy.21815 |
0.647 |
|
| 2009 |
Parisi T, Bronson RT, Lees JA. Inhibition of pituitary tumors in Rb mutant chimeras through E2f4 loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis. Oncogene. 28: 500-8. PMID 18997819 DOI: 10.1038/Onc.2008.406 |
0.446 |
|
| 2008 |
King JC, Moskowitz IP, Burgon PG, Ahmad F, Stone JR, Seidman JG, Lees JA. E2F3 plays an essential role in cardiac development and function. Cell Cycle (Georgetown, Tex.). 7: 3775-80. PMID 19029823 DOI: 10.4161/Cc.7.23.7240 |
0.379 |
|
| 2008 |
Berman SD, Yuan TL, Miller ES, Lee EY, Caron A, Lees JA. The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development. Molecular Cancer Research : McR. 6: 1440-51. PMID 18819932 DOI: 10.1158/1541-7786.Mcr-08-0176 |
0.431 |
|
| 2008 |
Berman SD, Calo E, Landman AS, Danielian PS, Miller ES, West JC, Fonhoue BD, Caron A, Bronson R, Bouxsein ML, Mukherjee S, Lees JA. Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Proceedings of the National Academy of Sciences of the United States of America. 105: 11851-6. PMID 18697945 DOI: 10.1073/Pnas.0805462105 |
0.427 |
|
| 2008 |
Dovey JS, Zacharek SJ, Kim CF, Lees JA. Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Proceedings of the National Academy of Sciences of the United States of America. 105: 11857-62. PMID 18697930 DOI: 10.1073/Pnas.0803574105 |
0.352 |
|
| 2008 |
Danielian PS, Friesenhahn LB, Faust AM, West JC, Caron AM, Bronson RT, Lees JA. E2f3a and E2f3b make overlapping but different contributions to total E2f3 activity. Oncogene. 27: 6561-70. PMID 18663357 DOI: 10.1038/onc.2008.253 |
0.365 |
|
| 2008 |
MacInnes AW, Amsterdam A, Whittaker CA, Hopkins N, Lees JA. Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations. Proceedings of the National Academy of Sciences of the United States of America. 105: 10408-13. PMID 18641120 DOI: 10.1073/Pnas.0805036105 |
0.671 |
|
| 2008 |
Courel M, Friesenhahn L, Lees JA. E2f6 and Bmi1 cooperate in axial skeletal development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 1232-42. PMID 18366140 DOI: 10.1002/Dvdy.21516 |
0.414 |
|
| 2007 |
Iaquinta PJ, Lees JA. Life and death decisions by the E2F transcription factors. Current Opinion in Cell Biology. 19: 649-57. PMID 18032011 DOI: 10.1016/J.Ceb.2007.10.006 |
0.436 |
|
| 2007 |
Conboy CM, Spyrou C, Thorne NP, Wade EJ, Barbosa-Morais NL, Wilson MD, Bhattacharjee A, Young RA, Tavaré S, Lees JA, Odom DT. Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor. Plos One. 2: e1061. PMID 17957245 DOI: 10.1371/Journal.Pone.0001061 |
0.435 |
|
| 2007 |
Danielian PS, Bender Kim CF, Caron AM, Vasile E, Bronson RT, Lees JA. E2f4 is required for normal development of the airway epithelium. Developmental Biology. 305: 564-76. PMID 17383628 DOI: 10.1016/J.Ydbio.2007.02.037 |
0.405 |
|
| 2007 |
Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell. 11: 175-89. PMID 17292828 DOI: 10.1016/J.Ccr.2006.11.024 |
0.436 |
|
| 2007 |
Parisi T, Yuan TL, Faust AM, Caron AM, Bronson R, Lees JA. Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues. Molecular and Cellular Biology. 27: 2283-93. PMID 17210634 DOI: 10.1128/Mcb.01854-06 |
0.435 |
|
| 2006 |
Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA. DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Genes & Development. 20: 3117-29. PMID 17085480 DOI: 10.1101/Gad.1482106 |
0.765 |
|
| 2005 |
Iaquinta PJ, Aslanian A, Lees JA. Regulation of the Arf/p53 tumor surveillance network by E2F. Cold Spring Harbor Symposia On Quantitative Biology. 70: 309-16. PMID 16869767 DOI: 10.1101/Sqb.2005.70.050 |
0.496 |
|
| 2004 |
Aslanian A, Iaquinta PJ, Verona R, Lees JA. Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes & Development. 18: 1413-22. PMID 15175242 DOI: 10.1101/Gad.1196704 |
0.509 |
|
| 2004 |
Amsterdam A, Sadler KC, Lai K, Farrington S, Bronson RT, Lees JA, Hopkins N. Many ribosomal protein genes are cancer genes in zebrafish. Plos Biology. 2: E139. PMID 15138505 DOI: 10.1371/Journal.Pbio.0020139 |
0.649 |
|
| 2003 |
Ziebold U, Lee EY, Bronson RT, Lees JA. E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. Molecular and Cellular Biology. 23: 6542-52. PMID 12944480 DOI: 10.1128/Mcb.23.18.6542-6552.2003 |
0.409 |
|
| 2003 |
Baudino TA, Maclean KH, Brennan J, Parganas E, Yang C, Aslanian A, Lees JA, Sherr CJ, Roussel MF, Cleveland JL. Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss. Molecular Cell. 11: 905-14. PMID 12718877 DOI: 10.1016/S1097-2765(03)00102-3 |
0.418 |
|
| 2003 |
Landsberg RL, Sero JE, Danielian PS, Yuan TL, Lee EY, Lees JA. The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity. Proceedings of the National Academy of Sciences of the United States of America. 100: 2456-61. PMID 12604789 DOI: 10.1073/Pnas.0138064100 |
0.505 |
|
| 2002 |
Lee EY, Cam H, Ziebold U, Rayman JB, Lees JA, Dynlacht BD. E2F4 loss suppresses tumorigenesis in Rb mutant mice. Cancer Cell. 2: 463-72. PMID 12498715 DOI: 10.1016/S1535-6108(02)00207-6 |
0.511 |
|
| 2002 |
Fajas L, Landsberg RL, Huss-Garcia Y, Sardet C, Lees JA, Auwerx J. E2Fs regulate adipocyte differentiation. Developmental Cell. 3: 39-49. PMID 12110166 DOI: 10.1016/S1534-5807(02)00190-9 |
0.457 |
|
| 2002 |
Cloud JE, Rogers C, Reza TL, Ziebold U, Stone JR, Picard MH, Caron AM, Bronson RT, Lees JA. Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo. Molecular and Cellular Biology. 22: 2663-72. PMID 11909960 DOI: 10.1128/Mcb.22.8.2663-2672.2002 |
0.442 |
|
| 2002 |
Trimarchi JM, Lees JA. Sibling rivalry in the E2F family. Nature Reviews. Molecular Cell Biology. 3: 11-20. PMID 11823794 DOI: 10.1038/Nrm714 |
0.73 |
|
| 2001 |
Ziebold U, Reza T, Caron A, Lees JA. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes & Development. 15: 386-91. PMID 11230146 DOI: 10.1101/Gad.858801 |
0.427 |
|
| 2001 |
Gaubatz S, Lees JA, Lindeman GJ, Livingston DM. E2F4 is exported from the nucleus in a CRM1-dependent manner. Molecular and Cellular Biology. 21: 1384-92. PMID 11158323 DOI: 10.1128/Mcb.21.4.1384-1392.2001 |
0.486 |
|
| 2001 |
Trimarchi JM, Fairchild B, Wen J, Lees JA. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex Proceedings of the National Academy of Sciences. 98: 1519-1524. DOI: 10.1073/Pnas.98.4.1519 |
0.728 |
|
| 2000 |
Perren A, Komminoth P, Saremaslani P, Matter C, Feurer S, Lees JA, Heitz PU, Eng C. Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells. The American Journal of Pathology. 157: 1097-103. PMID 11021813 DOI: 10.1016/S0002-9440(10)64624-X |
0.382 |
|
| 2000 |
Humbert PO, Rogers C, Ganiatsas S, Landsberg RL, Trimarchi JM, Dandapani S, Brugnara C, Erdman S, Schrenzel M, Bronson RT, Lees JA. E2F4 is essential for normal erythrocyte maturation and neonatal viability. Molecular Cell. 6: 281-91. PMID 10983976 DOI: 10.1016/S1097-2765(00)00029-0 |
0.743 |
|
| 2000 |
Gimm O, Attié-Bitach T, Lees JA, Vekemans M, Eng C. Expression of the PTEN tumour suppressor protein during human development. Human Molecular Genetics. 9: 1633-9. PMID 10861290 DOI: 10.1093/Hmg/9.11.1633 |
0.346 |
|
| 2000 |
Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Baak JP, Lees JA, Weng LP, Eng C. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. Journal of the National Cancer Institute. 92: 924-30. PMID 10841828 DOI: 10.1093/Jnci/92.11.924 |
0.342 |
|
| 2000 |
Gimm O, Perren A, Weng LP, Marsh DJ, Yeh JJ, Ziebold U, Gil E, Hinze R, Delbridge L, Lees JA, Mutter GL, Robinson BG, Komminoth P, Dralle H, Eng C. Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. The American Journal of Pathology. 156: 1693-700. PMID 10793080 DOI: 10.1016/S0002-9440(10)65040-7 |
0.311 |
|
| 2000 |
Humbert PO, Verona R, Trimarchi JM, Rogers C, Dandapani S, Lees JA. E2f3 is critical for normal cellular proliferation Genes & Development. 14: 690-703. DOI: 10.1101/Gad.14.6.690 |
0.42 |
|
| 1999 |
Perren A, Weng LP, Boag AH, Ziebold U, Thakore K, Dahia PL, Komminoth P, Lees JA, Mulligan LM, Mutter GL, Eng C. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. The American Journal of Pathology. 155: 1253-60. PMID 10514407 DOI: 10.1016/S0002-9440(10)65227-3 |
0.313 |
|
| 1999 |
Lees JA, Weinberg RA. Tossing monkey wrenches into the clock: new ways of treating cancer. Proceedings of the National Academy of Sciences of the United States of America. 96: 4221-3. PMID 10200241 DOI: 10.1073/Pnas.96.8.4221 |
0.334 |
|
| 1999 |
Gil EB, Malone Link E, Liu LX, Johnson CD, Lees JA. Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene. Proceedings of the National Academy of Sciences of the United States of America. 96: 2925-30. PMID 10077613 DOI: 10.1073/Pnas.96.6.2925 |
0.388 |
|
| 1999 |
Brugarolas J, Moberg K, Boyd SD, Taya Y, Jacks T, Lees JA. Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation. Proceedings of the National Academy of Sciences of the United States of America. 96: 1002-7. PMID 9927683 DOI: 10.1073/Pnas.96.3.1002 |
0.711 |
|
| 1998 |
Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proceedings of the National Academy of Sciences of the United States of America. 95: 2850-5. PMID 9501179 DOI: 10.1073/Pnas.95.6.2850 |
0.782 |
|
| 1997 |
Verona R, Moberg K, Estes S, Starz M, Vernon JP, Lees JA. E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Molecular and Cellular Biology. 17: 7268-82. PMID 9372959 DOI: 10.1128/Mcb.17.12.7268 |
0.706 |
|
| 1997 |
Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L. Specific regulation of E2F family members by cyclin-dependent kinases. Molecular and Cellular Biology. 17: 3867-75. PMID 9199321 DOI: 10.1128/Mcb.17.7.3867 |
0.668 |
|
| 1996 |
Moberg K, Starz MA, Lees JA. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry. Molecular and Cellular Biology. 16: 1436-49. PMID 8657117 DOI: 10.1128/Mcb.16.4.1436 |
0.704 |
|
| 1995 |
Zhu L, Enders G, Lees JA, Beijersbergen RL, Bernards R, Harlow E. The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. The Embo Journal. 14: 1904-13. PMID 7743997 DOI: 10.1002/J.1460-2075.1995.Tb07182.X |
0.409 |
|
| 1995 |
Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA. In vivo association of E2F and DP family proteins. Molecular and Cellular Biology. 15: 2536-46. PMID 7739537 DOI: 10.1128/Mcb.15.5.2536 |
0.483 |
|
| 1994 |
Dynlacht BD, Flores O, Lees JA, Harlow E. Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes & Development. 8: 1772-86. PMID 7958856 DOI: 10.1101/Gad.8.15.1772 |
0.472 |
|
| 1994 |
Zhu L, Enders GH, Wu CL, Starz MA, Moberg KH, Lees JA, Dyson N, Harlow E. Growth suppression by members of the retinoblastoma protein family. Cold Spring Harbor Symposia On Quantitative Biology. 59: 75-84. PMID 7587134 DOI: 10.1101/Sqb.1994.059.01.011 |
0.625 |
|
| 1993 |
Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes & Development. 7: 1850-61. PMID 8405995 DOI: 10.1101/Gad.7.10.1850 |
0.431 |
|
| 1993 |
Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K. The retinoblastoma protein binds to a family of E2F transcription factors. Molecular and Cellular Biology. 13: 7813-25. PMID 8246996 DOI: 10.1128/Mcb.13.12.7813 |
0.459 |
|
| 1992 |
Helin K, Lees JA, Vidal M, Dyson N, Harlow E, Fattaey A. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell. 70: 337-50. PMID 1638634 DOI: 10.1016/0092-8674(92)90107-N |
0.421 |
|
| 1992 |
Hu QJ, Lees JA, Buchkovich KJ, Harlow E. The retinoblastoma protein physically associates with the human cdc2 kinase. Molecular and Cellular Biology. 12: 971-80. PMID 1545827 DOI: 10.1128/Mcb.12.3.971 |
0.363 |
|
| 1992 |
Danielian P, White R, Lees J, Parker M. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. The Embo Journal. 11: 1025-1033. DOI: 10.1002/J.1460-2075.1992.Tb05141.X |
0.336 |
|
| 1991 |
Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E. The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. The Embo Journal. 10: 4279-90. PMID 1756735 DOI: 10.1002/J.1460-2075.1991.Tb05006.X |
0.384 |
|
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