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Hiroyuki Osada - Publications

Affiliations: 
Chemical Biology Research Group RIKEN 
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57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Liu X, Sanada E, Li J, Li X, Osada H, Watanabe N. Isolation and characterization of β-transducin repeat-containing protein ligands screened using a high-throughput screening system. Oncology Research. 31: 645-654. PMID 37547765 DOI: 10.32604/or.2023.030240  0.614
2023 Liu Z, Okano A, Sanada E, Futamura Y, Nogawa T, Ishikawa K, Semba K, Li J, Li X, Osada H, Watanabe N. Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc. Oncology Research. 31: 655-666. PMID 37547761 DOI: 10.32604/or.2023.030248  0.625
2023 Liu Z, Ishikawa K, Sanada E, Semba K, Li J, Li X, Osada H, Watanabe N. Identification of antimycin A as a c-Myc degradation accelerator via high-throughput screening. The Journal of Biological Chemistry. 105083. PMID 37495110 DOI: 10.1016/j.jbc.2023.105083  0.62
2023 Tan FHP, Ting ACJ, Najimudin N, Watanabe N, Shamsuddin S, Zainuddin A, Osada H, Azzam G. 3-[[(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carbonyl]amino]propanoic acid (THICAPA) is protective against Aβ42-induced toxicity in vitro and in an Alzheimer's Disease Drosophila. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 37453137 DOI: 10.1093/gerona/glad169  0.544
2022 Aoyama M, Ishikawa K, Nemoto S, Hirano H, Watanabe N, Osada H, Watanabe S, Semba K. Lonidamine and domperidone inhibit expansion of transformed cell areas by modulating motility of surrounding non-transformed cells. The Journal of Biological Chemistry. 102635. PMID 36273581 DOI: 10.1016/j.jbc.2022.102635  0.606
2022 Bürger M, Honda K, Kondoh Y, Hong S, Watanabe N, Osada H, Chory J. Crystal structure of DWARF14-LIKE2 (DLK2) reveals a distinct substrate binding pocket architecture. Plant Direct. 6: e446. PMID 36172078 DOI: 10.1002/pld3.446  0.599
2022 Cho N, Kikuzato K, Futamura Y, Shimizu T, Hayase H, Kamisaka K, Takaya D, Yuki H, Honma T, Niikura M, Kobayashi F, Watanabe N, Osada H, Koyama H. New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety. Bioorganic & Medicinal Chemistry. 66: 116830. PMID 35594648 DOI: 10.1016/j.bmc.2022.116830  0.6
2022 Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H. Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1). Acs Chemical Biology. 17: 483-491. PMID 35128925 DOI: 10.1021/acschembio.2c00028  0.67
2021 Lee JW, Ong TG, Samian MR, Teh AH, Watanabe N, Osada H, Ong EBB. Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae. Scientific Reports. 11: 24148. PMID 34921163 DOI: 10.1038/s41598-021-03490-7  0.598
2021 Moon JY, Adams E, Miyazaki T, Kondoh Y, Muroi M, Watanabe N, Osada H, Shin R. Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana. Scientific Reports. 11: 21109. PMID 34702872 DOI: 10.1038/s41598-021-00564-4  0.565
2021 Nakatani K, Maehama T, Nishio M, Otani J, Yamaguchi K, Fukumoto M, Hikasa H, Hagiwara S, Nishina H, Mak TW, Honma T, Kondoh Y, Osada H, Yoshida M, Suzuki A. Alantolactone is a natural product that potently inhibits YAP1/TAZ via promotion of ROS accumulation. Cancer Science. PMID 34289205 DOI: 10.1111/cas.15079  0.359
2021 Wilke J, Kawamura T, Xu H, Brause A, Friese A, Metz M, Schepmann D, Wünsch B, Artacho-Cordón A, Nieto FR, Watanabe N, Osada H, Ziegler S, Waldmann H. Discovery of a σ receptor antagonist by combination of unbiased cell painting and thermal proteome profiling. Cell Chemical Biology. PMID 33567254 DOI: 10.1016/j.chembiol.2021.01.009  0.62
2020 Suvarna K, Honda K, Muroi M, Kondoh Y, Watanabe N, Osada H. Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry. Bio-Protocol. 10: e3517. PMID 33654742 DOI: 10.21769/BioProtoc.3517  0.623
2020 Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N. Measurement of ATPase Activity of Valosin-containing Protein/p97. Bio-Protocol. 10: e3516. PMID 33654741 DOI: 10.21769/BioProtoc.3516  0.618
2020 Kawamura T, Futamura Y, Shang E, Muroi M, Janning P, Ueno M, Wilke J, Takeda S, Kondoh Y, Ziegler S, Watanabe N, Waldmann H, Osada H. Discovery of small-molecule modulator of heterotrimeric G-protein by integrated phenotypic profiling and chemical proteomics. Bioscience, Biotechnology, and Biochemistry. 1-7. PMID 32867616 DOI: 10.1080/09168451.2020.1812375  0.642
2020 Suvarna K, Honda K, Muroi M, Kondoh Y, Watanabe N, Osada H. Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry Bio-Protocol. 10. DOI: 10.21769/bioprotoc.3517  0.595
2020 Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N. Measurement of ATPase Activity of Valosin-containing Protein/p97 Bio-Protocol. 10. DOI: 10.21769/bioprotoc.3516  0.571
2019 Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H. Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA. Cell Chemical Biology. PMID 31813846 DOI: 10.1016/j.chembiol.2019.11.010  0.315
2019 Kwong MMY, Lee JW, Samian MR, Watanabe N, Osada H, Ong EBB. Comparison of microplate- and bottle-based methods to age yeast for chronological life span assays. Journal of Microbiological Methods. 105743. PMID 31629019 DOI: 10.1016/j.mimet.2019.105743  0.521
2019 Takase S, Kurokawa R, Kondoh Y, Honda K, Suzuki T, Kawahara T, Ikeda H, Dohmae N, Osada H, Shin-Ya K, Kushiro T, Yoshida M, Matsumoto K. Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure. Acs Chemical Biology. PMID 31365229 DOI: 10.1021/acschembio.9b00410  0.319
2019 Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H. A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition. Febs Letters. PMID 30874300 DOI: 10.1002/1873-3468.13361  0.631
2019 Murashima A, Shinjo K, Katsushima K, Onuki T, Kondoh Y, Osada H, Kagaya N, Shinya K, Kimura H, Yoshida M, Murakami S, Kondo Y. Identification of a Chemical Modulator of EZH2-mediated Silencing by Cell-based High-throughput Screening Assay. Journal of Biochemistry. PMID 30690451 DOI: 10.1093/jb/mvz007  0.309
2019 Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N. A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration. The Journal of Biological Chemistry. PMID 30610116 DOI: 10.1074/jbc.RA118.004741  0.646
2019 Förster T, Shang E, Shimizu K, Sanada E, Schölermann B, Huebecker M, Hahne G, López-Alberca MP, Janning P, Watanabe N, Sievers S, Giordanetto F, Shimizu T, Ziegler S, Osada H, et al. 2-Sulfonylpyrimidines Target the Kinesin HSET via Cysteine Alkylation European Journal of Organic Chemistry. 2019: 5486-5496. DOI: 10.1002/Ejoc.201900586  0.561
2018 Robke L, Futamura Y, Konstantinidis G, Wilke J, Aono H, Mahmoud Z, Watanabe N, Wu YW, Osada H, Laraia L, Waldmann H. Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I. Chemical Science. 9: 3014-3022. PMID 29732085 DOI: 10.1039/C7Sc05040B  0.596
2018 Suvarna K, Honda K, Kondoh Y, Osada H, Watanabe N. Identification of a small-molecule ligand of β-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells. Cancer Medicine. PMID 29380537 DOI: 10.1002/cam4.1339  0.636
2017 Wilke J, Kawamura T, Watanabe N, Osada H, Ziegler S, Waldmann H. Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion. Bioorganic & Medicinal Chemistry. PMID 29170028 DOI: 10.1016/J.Bmc.2017.11.009  0.594
2017 Waldmann H, Robke L, Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Wu Y, Engel J. Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34. Angewandte Chemie (International Ed. in English). PMID 28544137 DOI: 10.1002/Anie.201703738  0.626
2017 Nogawa T, Ogita N, Futamura Y, Negishi S, Watanabe N, Osada H. Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684. The Journal of Antibiotics. PMID 28096547 DOI: 10.1038/ja.2016.167  0.558
2016 Ong WD, Okubo-Kurihara E, Kurihara Y, Shimada S, Makita Y, Kawashima M, Honda K, Kondoh Y, Watanabe N, Osada H, Cutler SR, Sudesh K, Matsui M. Chemical-Induced Inhibition of Blue Light-Mediated Seedling Development Caused by Disruption of Upstream Signal Transduction Involving Cryptochromes in Arabidopsis thaliana. Plant & Cell Physiology. PMID 28011868 DOI: 10.1093/Pcp/Pcw181  0.573
2016 Kumar A, Kawamura T, Kawatani M, Osada H, Zhang KY. Identification and structure activity relationship of purine derivatives as novel MTH1 inhibitors. Chemical Biology & Drug Design. PMID 27863017 DOI: 10.1111/cbdd.12909  0.323
2016 Kondoh Y, Honda K, Hiranuma S, Hayashi T, Shimizu T, Watanabe N, Osada H. Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ. Scientific Reports. 6: 29881. PMID 27431267 DOI: 10.1038/srep29881  0.65
2016 Subedi A, Futamura Y, Nishi M, Ryo A, Watanabe N, Osada H. High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism. Biochemical and Biophysical Research Communications. PMID 27363336 DOI: 10.1016/j.bbrc.2016.06.128  0.604
2016 Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H. Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival. Scientific Reports. 6: 26521. PMID 27210421 DOI: 10.1038/srep26521  0.326
2016 Subedi A, Shimizu T, Ryo A, Sanada E, Watanabe N, Osada H. Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening. Biochemical and Biophysical Research Communications. PMID 27120460 DOI: 10.1016/j.bbrc.2016.04.124  0.655
2016 Ursu A, Illich DJ, Takemoto Y, Porfetye AT, Zhang M, Brockmeyer A, Janning P, Watanabe N, Osada H, Vetter IR, Ziegler S, Schöler HR, Waldmann H. Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chemical Biology. PMID 27049670 DOI: 10.1016/J.Chembiol.2016.02.015  0.61
2016 Watanabe N, Osada H. Small molecules that target phosphorylation dependent protein-protein interaction. Bioorganic & Medicinal Chemistry. PMID 27017542 DOI: 10.1016/j.bmc.2016.03.023  0.62
2015 Hayase H, Watanabe N, Lim CL, Nogawa T, Komatsuya K, Kita K, Osada H. Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity. Bioscience, Biotechnology, and Biochemistry. 79: 633-5. PMID 25471083 DOI: 10.1080/09168451.2014.987205  0.57
2014 Choi SB, Choong YS, Saito A, Wahab HA, Najimudin N, Watanabe N, Osada H, Ong EB. In Silico Investigation of a HIV-1 Vpr Inhibitor Binding Site: Potential for Virtual Screening and anti-HIV Drug Design. Molecular Informatics. 33: 742-8. PMID 27485420 DOI: 10.1002/minf.201400080  0.62
2013 Ooi LC, Watanabe N, Futamura Y, Sulaiman SF, Darah I, Osada H. Identification of small molecule inhibitors of p27(Kip1) ubiquitination by high-throughput screening. Cancer Science. 104: 1461-7. PMID 23910095 DOI: 10.1111/cas.12246  0.642
2013 Zimmermann TJ, Bürger M, Tashiro E, Kondoh Y, Martinez NE, Görmer K, Rosin-Steiner S, Shimizu T, Ozaki S, Mikoshiba K, Watanabe N, Hall D, Vetter IR, Osada H, Hedberg C, et al. Boron-based inhibitors of acyl protein thioesterases 1 and 2. Chembiochem : a European Journal of Chemical Biology. 14: 115-22. PMID 23239555 DOI: 10.1002/Cbic.201200571  0.635
2013 Kondoh Y, Osada H. High-throughput screening identifies small molecule inhibitors of molecular chaperones. Current Pharmaceutical Design. 19: 473-92. PMID 22920900  0.31
2012 Watanabe N, Osada H. [Small molecule inhibitors of phosphorylation specific peptidyl prolyl cis-trans isomerase Pin1]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 70: 709-17. PMID 23513925  0.58
2012 Futamura Y, Kawatani M, Kazami S, Tanaka K, Muroi M, Shimizu T, Tomita K, Watanabe N, Osada H. Morphobase, an encyclopedic cell morphology database, and its use for drug target identification. Chemistry & Biology. 19: 1620-30. PMID 23261605 DOI: 10.1016/j.chembiol.2012.10.014  0.616
2012 Watanabe N, Osada H. [Cell cycle]. Nihon Rinsho. Japanese Journal of Clinical Medicine. 70: 79-85. PMID 23133932  0.554
2012 Watanabe N, Osada H. Phosphorylation-dependent protein-protein interaction modules as potential molecular targets for cancer therapy. Current Drug Targets. 13: 1654-8. PMID 23030498  0.636
2012 Bürger M, Zimmermann TJ, Kondoh Y, Stege P, Watanabe N, Osada H, Waldmann H, Vetter IR. Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases. Journal of Lipid Research. 53: 43-50. PMID 22052940 DOI: 10.1194/Jlr.M019851  0.604
2011 Ong EB, Watanabe N, Saito A, Futamura Y, Abd El Galil KH, Koito A, Najimudin N, Osada H. Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR. The Journal of Biological Chemistry. 286: 14049-56. PMID 21357691 DOI: 10.1074/jbc.M110.185397  0.64
2010 Yashiroda Y, Okamoto R, Hatsugai K, Takemoto Y, Goshima N, Saito T, Hamamoto M, Sugimoto Y, Osada H, Seimiya H, Yoshida M. A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor. Biochemical and Biophysical Research Communications. 394: 569-73. PMID 20214890 DOI: 10.1016/J.Bbrc.2010.03.021  0.34
2009 Kawai K, Saito A, Sudo T, Osada H. A p38 mitogen-activated protein kinase inhibitor screening method using growth recovery of Escherichia coli as an index. Analytical Biochemistry. 388: 128-33. PMID 19248755 DOI: 10.1016/j.ab.2009.02.022  0.313
2009 Watanabe N, Sekine T, Takagi M, Iwasaki J, Imamoto N, Kawasaki H, Osada H. Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition. The Journal of Biological Chemistry. 284: 2344-53. PMID 19033445 DOI: 10.1074/jbc.M805308200  0.634
2006 Watanabe N, Nishihara Y, Yamaguchi T, Koito A, Miyoshi H, Kakeya H, Osada H. Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity. Febs Letters. 580: 2598-602. PMID 16631749 DOI: 10.1016/j.febslet.2006.04.007  0.622
2005 Nakazawa J, Watanabe N, Imoto M, Osada H. Mutational analysis of growth arrest and cellular localization of human immunodeficiency virus type 1 Vpr in the budding yeast, Saccharomyces cerevisiae. The Journal of General and Applied Microbiology. 51: 245-56. PMID 16205032 DOI: JST.JSTAGE/jgam/51.245  0.591
2005 Watanabe N, Arai H, Iwasaki J, Shiina M, Ogata K, Hunter T, Osada H. Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Proceedings of the National Academy of Sciences of the United States of America. 102: 11663-8. PMID 16085715 DOI: 10.1073/Pnas.0500410102  0.584
2005 Teruya T, Simizu S, Kanoh N, Osada H. Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells. Febs Letters. 579: 2463-8. PMID 15848189 DOI: 10.1016/j.febslet.2005.03.049  0.355
2004 Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H. M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proceedings of the National Academy of Sciences of the United States of America. 101: 4419-24. PMID 15070733 DOI: 10.1073/Pnas.0307700101  0.587
2002 Ueda K, Usui T, Nakayama H, Ueki M, Takio K, Ubukata M, Osada H. 4-isoavenaciolide covalently binds and inhibits VHR, a dual-specificity phosphatase. Febs Letters. 525: 48-52. PMID 12163160 DOI: 10.1016/S0014-5793(02)03065-X  0.318
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