| Year |
Citation |
Score |
| 2023 |
Zhang KK, Burns CM, Skinner ME, Lombard DB, Miller RA, Endicott SJ. PTEN is both an activator and a substrate of chaperone-mediated autophagy. The Journal of Cell Biology. 222. PMID 37418003 DOI: 10.1083/jcb.202208150 |
0.319 |
|
| 2023 |
Baek J, Sas K, He C, Nair V, Giblin W, Inoki A, Zhang H, Yingbao Y, Hodgin J, Nelson RG, Brosius FC, Kretzler M, Stemmer PM, Lombard DB, Pennathur S. The Deacylase Sirtuin 5 Reduces Malonylation in Non-mitochondrial Metabolic Pathways in Diabetic Kidney Disease. The Journal of Biological Chemistry. 102960. PMID 36736426 DOI: 10.1016/j.jbc.2023.102960 |
0.314 |
|
| 2022 |
Guo AH, Baliira R, Skinner ME, Kumar S, Andren A, Zhang L, Goldsmith RS, Michan S, Davis NJ, Maccani MW, Day SM, Sinclair DA, Brody MJ, Lyssiotis CA, Stein AB, ... Lombard DB, et al. Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload. Scientific Reports. 12: 12258. PMID 35851833 DOI: 10.1038/s41598-022-16506-7 |
0.497 |
|
| 2022 |
Kerk S, Lin L, Myers AL, Sutton DJ, Andren A, Sajjakulnukit P, Zhang L, Zhang Y, Jiménez JA, Nelson BS, Chen B, Robinson A, Thurston G, Kemp SB, Steele NG, ... ... Lombard DB, et al. Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context. Elife. 11. PMID 35815941 DOI: 10.7554/eLife.73245 |
0.61 |
|
| 2021 |
Giblin W, Bringman-Rodenbarger L, Guo AH, Kumar S, Monovich AC, Mostafa AM, Skinner ME, Azar M, Mady AS, Chung CH, Kadambi N, Melong KA, Lee HJ, Zhang L, Sajjakulnukit P, ... ... Lombard DB, et al. The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics. The Journal of Clinical Investigation. PMID 33945506 DOI: 10.1172/JCI138926 |
0.64 |
|
| 2020 |
Little AC, Kovalenko I, Goo LE, Hong HS, Kerk SA, Yates JA, Purohit V, Lombard DB, Merajver SD, Lyssiotis CA. High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions. Communications Biology. 3: 271. PMID 32472013 DOI: 10.1038/s42003-020-0988-z |
0.592 |
|
| 2020 |
Steen K, Chen D, Wang F, Majumdar R, Chen S, Kumar S, Lombard DB, Weigert R, Zieman AG, Parent CA, Coulombe PA. A role for keratins in supporting mitochondrial organization and function in skin keratinocytes. Molecular Biology of the Cell. mbcE19100565. PMID 32213122 DOI: 10.1091/Mbc.E19-10-0565 |
0.421 |
|
| 2020 |
Elesela S, Morris SB, Narayanan S, Kumar S, Lombard DB, Lukacs NW. Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells. Plos Pathogens. 16: e1008319. PMID 32106265 DOI: 10.1371/Journal.Ppat.1008319 |
0.403 |
|
| 2020 |
Lombard D. Novel Roles for the Sirtuin Deacylase SIRT5 in Normal Physiology and in Cancer Innovation in Aging. 4: 741-741. DOI: 10.1093/geroni/igaa057.2652 |
0.421 |
|
| 2019 |
Korfhage J, Lombard DB. Malignant Peripheral Nerve Sheath Tumors: From Epigenome to Bedside. Molecular Cancer Research : McR. PMID 31023785 DOI: 10.1158/1541-7786.Mcr-19-0147 |
0.336 |
|
| 2019 |
Lombard DB, Cierpicki T, Grembecka J. Combined MAPK Pathway and HDAC Inhibition Breaks Melanoma. Cancer Discovery. 9: 469-471. PMID 30936219 DOI: 10.1158/2159-8290.Cd-19-0069 |
0.353 |
|
| 2019 |
Chefetz I, Grimley E, Yang K, Hong L, Vinogradova EV, Suciu R, Kovalenko I, Karnak D, Morgan CA, Chtcherbinine M, Buchman C, Huddle B, Barraza S, Morgan M, Bernstein KA, ... ... Lombard DB, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Reports. 26: 3061-3075.e6. PMID 30865894 DOI: 10.1016/J.Celrep.2019.02.032 |
0.353 |
|
| 2018 |
Wong K, Robles-Espinoza CD, Rodriguez D, Rudat SS, Puig S, Potrony M, Wong CC, Hewinson J, Aguilera P, Puig-Butille JA, Bressac-de Paillerets B, Zattara H, van der Weyden L, Fletcher CDM, Brenn T, ... ... Lombard DB, et al. Association of the POT1 Germline Missense Variant p.I78T With Familial Melanoma. Jama Dermatology. PMID 30586141 DOI: 10.1001/Jamadermatol.2018.3662 |
0.361 |
|
| 2018 |
Toubai T, Tamaki H, Peltier DC, Rossi C, Oravecz-Wilson K, Liu C, Zajac C, Wu J, Sun Y, Fujiwara H, Henig I, Kim S, Lombard DB, Reddy P. Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation. Journal of Immunology (Baltimore, Md. : 1950). PMID 30389773 DOI: 10.4049/Jimmunol.1800148 |
0.347 |
|
| 2018 |
Kumar S, Lombard DB. Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology. Critical Reviews in Biochemistry and Molecular Biology. 53: 311-334. PMID 29637793 DOI: 10.1080/10409238.2018.1458071 |
0.503 |
|
| 2017 |
Bringman-Rodenbarger LR, Guo AH, Lyssiotis CA, Lombard DB. Emerging roles for SIRT5 in metabolism and cancer. Antioxidants & Redox Signaling. PMID 28707979 DOI: 10.1089/Ars.2017.7264 |
0.647 |
|
| 2017 |
Lombard DB, Zhao Y. ACSF3 and Mal(onate)-Adapted Mitochondria. Cell Chemical Biology. 24: 649-650. PMID 28644952 DOI: 10.1016/J.Chembiol.2017.06.004 |
0.404 |
|
| 2017 |
Kumar S, Lombard DB. Cycling around Lysine Modifications. Trends in Biochemical Sciences. PMID 28595832 DOI: 10.1016/J.Tibs.2017.05.006 |
0.38 |
|
| 2017 |
Kumar S, Lombard DB. For Certain, SIRT4 Activities! Trends in Biochemical Sciences. PMID 28587732 DOI: 10.1016/J.Tibs.2017.05.008 |
0.31 |
|
| 2017 |
Cho CS, Lombard DB, Lee JH. SIRT3 as a Regulator of Hepatic Autophagy. Hepatology (Baltimore, Md.). PMID 28520180 DOI: 10.1002/Hep.29271 |
0.303 |
|
| 2017 |
Kump KJ, Miao L, Mady AS, Lev K, Giblin W, Skinner ME, Lombard DB, Nikolovska-Coleska Z. Abstract 1173: A novel selective Mcl-1 inhibitor exhibitsin vitroandin vivoefficacy in melanoma Cancer Research. 77: 1173-1173. DOI: 10.1158/1538-7445.Am2017-1173 |
0.413 |
|
| 2016 |
Kumar S, Lombard DB. Generation and Purification of Catalytically Active Recombinant Sirtuin5 (SIRT5) Protein. Methods in Molecular Biology (Clifton, N.J.). 1436: 241-57. PMID 27246219 DOI: 10.1007/978-1-4939-3667-0_16 |
0.431 |
|
| 2016 |
Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, ... ... Lombard DB, et al. Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation. Molecular Cell. 62: 194-206. PMID 27105115 DOI: 10.1016/J.Molcel.2016.03.036 |
0.375 |
|
| 2016 |
Kumar S, Lombard DB. Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules. F1000research. 5. PMID 27081480 DOI: 10.12688/F1000Research.7821.1 |
0.304 |
|
| 2016 |
Park J, Chen K, Park J, Pak M, Verhaegen M, Fullen D, Scott D, Osterman A, Wang M, Andea A, Prichard A, Scolyer R, Wilmott J, Lombard DB. Human Melanoma Cell Need SIRT5 to Survive Free Radical Biology and Medicine. 100: S128. DOI: 10.1016/J.Freeradbiomed.2016.10.334 |
0.52 |
|
| 2016 |
Park J, Chen K, Park J, Lombard DB. TOR Signal Is Suppressed by Sirt5 in Different Nutrient Condition Free Radical Biology and Medicine. 100: S86. DOI: 10.1016/J.Freeradbiomed.2016.10.215 |
0.417 |
|
| 2015 |
Guetschow ED, Kumar S, Lombard DB, Kennedy RT. Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples. Analytical and Bioanalytical Chemistry. PMID 26635020 DOI: 10.1007/S00216-015-9206-0 |
0.303 |
|
| 2015 |
Novgorodov SA, Riley CL, Keffler JA, Yu J, Kindy MS, Macklin WB, Lombard DB, Gudz TI. SIRT3 Deacetylates Ceramide Synthases: Implications for Mitochondrial Dysfunction and Brain Injury. The Journal of Biological Chemistry. PMID 26620563 DOI: 10.1074/Jbc.M115.668228 |
0.357 |
|
| 2015 |
Lombard DB, Dash BP, Kumar S. Acetyl-ed question in mitochondrial biology? The Embo Journal. 34: 2597-600. PMID 26369717 DOI: 10.15252/Embj.201592927 |
0.417 |
|
| 2015 |
Colak G, Pougovkina O, Dai L, Tan M, Te Brinke H, Huang H, Cheng Z, Park J, Wan X, Liu X, Yue WW, Wanders RJ, Locasale JW, Lombard DB, de Boer VC, et al. Proteomic and biochemical studies of lysine malonylation suggests its malonic aciduria-associated regulatory role in mitochondrial function and fatty acid oxidation. Molecular & Cellular Proteomics : McP. PMID 26320211 DOI: 10.1074/Mcp.M115.048850 |
0.426 |
|
| 2015 |
Kumar S, Lombard DB. Mitochondrial sirtuins and their relationships with metabolic disease and cancer. Antioxidants & Redox Signaling. 22: 1060-77. PMID 25545135 DOI: 10.1089/Ars.2014.6213 |
0.474 |
|
| 2014 |
Zwaans BM, Lombard DB. Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming. Disease Models & Mechanisms. 7: 1023-32. PMID 25085992 DOI: 10.1242/Dmm.016287 |
0.471 |
|
| 2014 |
Giblin W, Skinner ME, Lombard DB. Sirtuins: guardians of mammalian healthspan. Trends in Genetics : Tig. 30: 271-86. PMID 24877878 DOI: 10.1016/J.Tig.2014.04.007 |
0.324 |
|
| 2014 |
Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, ... ... Lombard DB, et al. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metabolism. 19: 605-17. PMID 24703693 DOI: 10.1016/J.Cmet.2014.03.014 |
0.423 |
|
| 2014 |
Hong S, Zhao B, Lombard DB, Fingar DC, Inoki K. Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation. The Journal of Biological Chemistry. 289: 13132-41. PMID 24652283 DOI: 10.1074/Jbc.M113.520734 |
0.33 |
|
| 2014 |
Lombard DB, Zwaans BM. SIRT3: as simple as it seems? Gerontology. 60: 56-64. PMID 24192814 DOI: 10.1159/000354382 |
0.447 |
|
| 2013 |
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Molecular Cell. 50: 919-30. PMID 23806337 DOI: 10.1016/J.Molcel.2013.06.001 |
0.486 |
|
| 2013 |
Wirth M, Karaca S, Wenzel D, Ho L, Tishkoff D, Lombard DB, Verdin E, Urlaub H, Jedrusik-Bode M, Fischle W. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Mitochondrion. 13: 705-20. PMID 23438705 DOI: 10.1016/J.Mito.2013.02.002 |
0.396 |
|
| 2013 |
Park J, Lombard DB. SIRT5 Regulates Mitochondrial Functions through Modulating Diverse Lysine Post-Translational Modifications Free Radical Biology and Medicine. 65: S152. DOI: 10.1016/J.Freeradbiomed.2013.10.779 |
0.376 |
|
| 2012 |
Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, ... ... Lombard DB, et al. The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell. 151: 1185-99. PMID 23217706 DOI: 10.1016/J.Cell.2012.10.047 |
0.457 |
|
| 2012 |
Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, Fergusson MM, Liu J, Rovira II, Cheng HL, Wang G, Gucek M, Lombard D, Alt FW, Sack MN, et al. The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature. 492: 199-204. PMID 23201684 DOI: 10.1038/Nature11700 |
0.338 |
|
| 2012 |
Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevanandam V, Cunningham JM, Deng CX, Lombard DB, Mostoslavsky R, Gupta MP. The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nature Medicine. 18: 1643-50. PMID 23086477 DOI: 10.1038/Nm.2961 |
0.335 |
|
| 2012 |
Chiang WC, Tishkoff DX, Yang B, Wilson-Grady J, Yu X, Mazer T, Eckersdorff M, Gygi SP, Lombard DB, Hsu AL. C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress. Plos Genetics. 8: e1002948. PMID 23028355 DOI: 10.1371/Journal.Pgen.1002948 |
0.355 |
|
| 2012 |
Lombard DB, Miller RA. Ageing: Sorting out the sirtuins. Nature. 483: 166-7. PMID 22367538 DOI: 10.1038/Nature10950 |
0.369 |
|
| 2011 |
Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Ho L, Lombard D, He TC, et al. The first identification of lysine malonylation substrates and its regulatory enzyme. Molecular & Cellular Proteomics : McP. 10: M111.012658. PMID 21908771 DOI: 10.1074/Mcp.M111.012658 |
0.378 |
|
| 2011 |
Lombard DB, Tishkoff DX, Bao J. Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation. Handbook of Experimental Pharmacology. 206: 163-88. PMID 21879450 DOI: 10.1007/978-3-642-21631-2_8 |
0.451 |
|
| 2011 |
Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, Verdin EM, Kahn CR. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proceedings of the National Academy of Sciences of the United States of America. 108: 14608-13. PMID 21873205 DOI: 10.1073/Pnas.1111308108 |
0.341 |
|
| 2011 |
Lu Z, Bourdi M, Li JH, Aponte AM, Chen Y, Lombard DB, Gucek M, Pohl LR, Sack MN. SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity. Embo Reports. 12: 840-6. PMID 21720390 DOI: 10.1038/Embor.2011.121 |
0.402 |
|
| 2010 |
Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metabolism. 12: 654-61. PMID 21109197 DOI: 10.1016/J.Cmet.2010.11.003 |
0.458 |
|
| 2010 |
Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proceedings of the National Academy of Sciences of the United States of America. 107: 21790-4. PMID 21098266 DOI: 10.1073/Pnas.1016306107 |
0.387 |
|
| 2010 |
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464: 121-5. PMID 20203611 DOI: 10.1038/Nature08778 |
0.42 |
|
| 2009 |
Yang B, Zwaans BM, Eckersdorff M, Lombard DB. The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability. Cell Cycle (Georgetown, Tex.). 8: 2662-3. PMID 19597350 DOI: 10.4161/Cc.8.16.9329 |
0.321 |
|
| 2009 |
Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB. Calorie restriction alters mitochondrial protein acetylation. Aging Cell. 8: 604-6. PMID 19594485 DOI: 10.1111/J.1474-9726.2009.00503.X |
0.42 |
|
| 2008 |
Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proceedings of the National Academy of Sciences of the United States of America. 105: 3374-9. PMID 18296641 DOI: 10.1073/Pnas.0712145105 |
0.475 |
|
| 2008 |
Lombard DB, Schwer B, Alt FW, Mostoslavsky R. SIRT6 in DNA repair, metabolism and ageing. Journal of Internal Medicine. 263: 128-41. PMID 18226091 DOI: 10.1111/J.1365-2796.2007.01902.X |
0.352 |
|
| 2008 |
Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, et al. Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Molecular and Cellular Biology. 28: 1688-701. PMID 18180281 DOI: 10.1128/Mcb.01154-06 |
0.366 |
|
| 2007 |
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Molecular and Cellular Biology. 27: 8807-14. PMID 17923681 DOI: 10.1128/Mcb.01636-07 |
0.472 |
|
| 2006 |
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 124: 315-29. PMID 16439206 DOI: 10.1016/J.Cell.2005.11.044 |
0.384 |
|
| 2006 |
Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer M, Stokes N, Murphy MM, Appella E, Alt FW. Erratum: Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress (Cell Metabolism) (2005) vol. 2 (67-76)) Cell Metabolism. 3. DOI: 10.1016/J.Cmet.2005.12.006 |
0.353 |
|
| 2005 |
Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N, Murphy MM, Appella E, Alt FW. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metabolism. 2: 67-76. PMID 16054100 DOI: 10.1016/J.Cmet.2005.06.007 |
0.35 |
|
| 2004 |
Du X, Shen J, Kugan N, Furth EE, Lombard DB, Cheung C, Pak S, Luo G, Pignolo RJ, DePinho RA, Guarente L, Johnson FB. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Molecular and Cellular Biology. 24: 8437-46. PMID 15367665 DOI: 10.1128/Mcb.24.19.8437-8446.2004 |
0.323 |
|
| 2004 |
Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nature Genetics. 36: 877-82. PMID 15235603 DOI: 10.1038/Ng1389 |
0.336 |
|
| 1998 |
Marciniak RA, Lombard DB, Johnson FB, Guarente L. Nucleolar localization of the Werner syndrome protein in human cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 6887-92. PMID 9618508 DOI: 10.1073/Pnas.95.12.6887 |
0.323 |
|
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