Megan K Levings - Publications

Affiliations: 
Surgery  

204 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Rosado-Sánchez I, Haque M, Salim K, Speck M, Fung VC, Boardman DA, Mojibian M, Raimondi G, Levings MK. Tregs integrate native and CAR-mediated costimulatory signals for control of allograft rejection. Jci Insight. 8. PMID 37669115 DOI: 10.1172/jci.insight.167215  0.346
2023 Spanier JA, Fung V, Wardell CM, Alkhatib MH, Chen Y, Swanson LA, Dwyer AJ, Weno ME, Silva N, Mitchell JS, Orban PC, Mojibian M, Verchere CB, Fife BT, Levings MK. Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes in mice. The Journal of Clinical Investigation. PMID 37561596 DOI: 10.1172/JCI168601  0.326
2023 Ellis CE, Mojibian M, Ida S, Fung VCW, Skovsø S, McIver E, O'Dwyer S, Webber TD, Braam MJS, Saber N, Sasaki S, Lynn FC, Kieffer TJ, Levings MK. Human A2-CAR T Cells Reject HLA-A2+ Human Islets Transplanted Into Mice Without Inducing Graft-Versus-Host Disease. Transplantation. PMID 37528526 DOI: 10.1097/TP.0000000000004709  0.381
2023 Tuomela K, Salim K, Levings MK. Eras of designer Tregs: Harnessing synthetic biology for immune suppression. Immunological Reviews. PMID 37522861 DOI: 10.1111/imr.13254  0.443
2023 Kim JV, Assadian S, Hollander Z, Burns P, Shannon CP, Lam K, Toma M, Ignaszewski A, Davies RA, Delgado D, Haddad H, Isaac D, Kim D, Mui A, Rajda M, ... ... Levings MK, et al. Regulatory T Cell Biomarkers Identify Patients at Risk of Developing Acute Cellular Rejection in the First Year Following Heart Transplantation. Transplantation. PMID 37365692 DOI: 10.1097/TP.0000000000004607  0.375
2023 Tuomela K, Levings MK. Acidity promotes the differentiation of immunosuppressive regulatory T cells. European Journal of Immunology. e2350511. PMID 37097063 DOI: 10.1002/eji.202350511  0.391
2023 Stankiewicz LN, Salim K, Flaschner EA, Wang YX, Edgar JM, Lin BZ, Bingham GC, Major MC, Jones RD, Blau HM, Rideout EJ, Levings MK, Zandstra PW, Rossi FM. Sex biased human thymic architecture guides T cell development through spatially defined niches. Biorxiv : the Preprint Server For Biology. PMID 37090676 DOI: 10.1101/2023.04.13.536804  0.37
2023 Haque M, Boardman DA, Levings MK. Alleviating graft-versus-host disease by directing regulatory T cells to the gut … it is all about location, location, location. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 37059178 DOI: 10.1016/j.ajt.2023.04.010  0.328
2023 Lamarche C, Ward-Hartstonge K, Mi T, Lin DTS, Huang Q, Brown A, Edwards K, Novakovsky GE, Qi CN, Kobor MS, Zebley CC, Weber EW, Mackall CL, Levings MK. Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219086120. PMID 36972454 DOI: 10.1073/pnas.2219086120  0.509
2023 Colpitts SJ, Budd MA, Monajemi M, Reid KT, Murphy JM, Ivison S, Verchere CB, Levings MK, Crome SQ. Strategies for optimizing CITE-seq for human islets and other tissues. Frontiers in Immunology. 14: 1107582. PMID 36936943 DOI: 10.3389/fimmu.2023.1107582  0.379
2023 Halvorson T, Tuomela K, Levings MK. Targeting regulatory T cell metabolism in disease: novel therapeutic opportunities. European Journal of Immunology. e2250002. PMID 36891988 DOI: 10.1002/eji.202250002  0.317
2023 Spanier JA, Fung V, Wardell CM, Alkhatib MH, Chen Y, Swanson LA, Dwyer AJ, Weno ME, Silva N, Mitchell JS, Orban PC, Mojibian M, Verchere CB, Fife BT, Levings MK. Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes. Biorxiv : the Preprint Server For Biology. PMID 36865264 DOI: 10.1101/2023.02.23.529737  0.331
2023 Ellis CE, Mojibian M, Ida S, Fung VCW, Skovsø S, McIver E, O'Dwyer S, Webber TD, Braam MJS, Saber N, Kieffer TJ, Levings MK. Human A2-CAR T cells reject HLA-A2+ human islets transplanted into mice without inducing graft versus host disease. Biorxiv : the Preprint Server For Biology. PMID 36865123 DOI: 10.1101/2023.02.23.529741  0.381
2023 Poloni C, Schonhofer C, Ivison S, Levings MK, Steiner TS, Cook L. T cell activation induced marker assays in health and disease. Immunology and Cell Biology. PMID 36825901 DOI: 10.1111/imcb.12636  0.387
2022 Haque M, Boardman DA, Lam AJ, MacDonald KN, Sanderink L, Huang Q, Fung VCW, Ivison S, Mojibian M, Levings MK. Modelling Graft-Versus-Host Disease in Mice Using Human Peripheral Blood Mononuclear Cells. Bio-Protocol. 12. PMID 36561116 DOI: 10.21769/BioProtoc.4566  0.801
2022 Boardman DA, Wong MQ, Rees WD, Wu D, Himmel ME, Orban PC, Vent-Schmidt J, Zachos NC, Steiner TS, Levings MK. Flagellin-specific human CAR Tregs for immune regulation in IBD. Journal of Autoimmunity. 134: 102961. PMID 36470208 DOI: 10.1016/j.jaut.2022.102961  0.404
2022 MacDonald KN, Salim K, Levings MK. Manufacturing next-generation regulatory T-cell therapies. Current Opinion in Biotechnology. 78: 102822. PMID 36332342 DOI: 10.1016/j.copbio.2022.102822  0.416
2022 Lordén G, Lam AJ, Levings MK, Newton AC. PHLPP Signaling in Immune Cells. Current Topics in Microbiology and Immunology. 436: 117-143. PMID 36243842 DOI: 10.1007/978-3-031-06566-8_5  0.786
2022 Lauener M, AzadPour S, Abdossamadi S, Parthasarathy V, Ng B, Ostroumov E, Cuvelier GDE, Levings MK, MacDonald KN, Kariminia A, Schultz KR. CD56brightCD16- natural killer cells as an important regulatory mechanism in chronic graftversus-host disease. Haematologica. PMID 36200416 DOI: 10.3324/haematol.2022.280653  0.403
2022 MacDonald KN, Hall MG, Ivison S, Gandhi S, Klein Geltink RI, Piret JM, Levings MK. Consequences of adjusting cell density and feed frequency on serum-free expansion of thymic regulatory T cells. Cytotherapy. PMID 36008207 DOI: 10.1016/j.jcyt.2022.06.006  0.404
2022 Proics E, David M, Mojibian M, Speck M, Lounnas-Mourey N, Govehovitch A, Baghdadi W, Desnouveaux J, Bastian H, Freschi L, Privat G, Pouzet C, Grossi M, Heimendinger P, Abel T, ... ... Levings MK, et al. Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation. Gene Therapy. PMID 35931871 DOI: 10.1038/s41434-022-00358-x  0.359
2022 Lam AJ, Haque M, Ward-Hartstonge KA, Uday P, Wardell CM, Gillies JK, Speck M, Mojibian M, Klein Geltink RI, Levings MK. PTEN is required for human Treg suppression of costimulation in vitro. European Journal of Immunology. PMID 35746855 DOI: 10.1002/eji.202249888  0.82
2022 Yang JHM, Ward-Hartstonge KA, Perry DJ, Blanchfield JL, Posgai AL, Wiedeman AE, Diggins K, Rahman A, Tree TIM, Brusko TM, Levings MK, James EA, Kent SC, Speake C, Homann D, et al. Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes. European Journal of Immunology. 52: 372-388. PMID 35025103 DOI: 10.1002/eji.202049067  0.33
2022 Boardman DA, Levings MK. Emerging strategies for treating autoimmune disorders with genetically modified Treg cells. The Journal of Allergy and Clinical Immunology. 149: 1-11. PMID 34998473 DOI: 10.1016/j.jaci.2021.11.007  0.417
2021 Huang Q, Lam AJ, Boardman DA, Dawson NAJ, Levings MK. Suppression of Human Dendritic Cells by Regulatory T Cells. Bio-Protocol. 11: e4217. PMID 34859131 DOI: 10.21769/BioProtoc.4217  0.835
2021 Lam AJ, Uday P, Gillies JK, Levings MK. Helios is a marker, not a driver, of human Treg stability. European Journal of Immunology. PMID 34561855 DOI: 10.1002/eji.202149318  0.828
2021 Budd MA, Monajemi M, Colpitts SJ, Crome SQ, Verchere CB, Levings MK. Interactions between islets and regulatory immune cells in health and type 1 diabetes. Diabetologia. 64: 2378-2388. PMID 34550422 DOI: 10.1007/s00125-021-05565-6  0.352
2021 Lam AJ, Lin DTS, Gillies JK, Uday P, Pesenacker AM, Kobor MS, Levings MK. Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity. Cell Reports. 36: 109494. PMID 34348163 DOI: 10.1016/j.celrep.2021.109494  0.805
2021 Pj White M, Smyth DJ, Cook L, Ziegler SF, Levings MK, Maizels RM. The parasite cytokine mimic Hp-TGM potently replicates the regulatory effects of TGF-β on murine CD4 T cells. Immunology and Cell Biology. PMID 33988885 DOI: 10.1111/imcb.12479  0.352
2021 Cook L, Reid KT, Häkkinen E, de Bie B, Tanaka S, Smyth DJ, White MP, Wong MQ, Huang Q, Gillies JK, Zeigler SF, Maizels RM, Levings MK. Induction of stable human FOXP3 Tregs by a parasite-derived TGF-β mimic. Immunology and Cell Biology. PMID 33929751 DOI: 10.1111/imcb.12475  0.429
2021 Fung VCW, Rosado-Sánchez I, Levings MK. Transduction of Human T Cell Subsets with Lentivirus. Methods in Molecular Biology (Clifton, N.J.). 2285: 227-254. PMID 33928557 DOI: 10.1007/978-1-0716-1311-5_19  0.443
2021 Ahmad I, Bijl J, Ivison S, Atenafu EG, Panzarella T, Broady R, Szwajcer D, Walker I, Kim DD, Bredeson C, Foley R, Hogge DE, Allan D, Delisle J, Schultz K, ... ... Levings M, et al. Continuous Alloreactive T Cell Depletion and Regulatory T Cell Expansion for the Treatment of Steroid- Refractory or Dependent Chronic GVHD – a Multicentre Phase II Clinical Trial (CARE Trial) Transplantation and Cellular Therapy. 27: S285. DOI: 10.1016/S2666-6367(21)00364-X  0.308
2020 Scott DW, Levings MK. Novel T regulatory cells come of age: The curious incident of a mouse in Tennessee, delayed thymectomy and chimeric receptors! Cellular Immunology. 359: 104253. PMID 33307362 DOI: 10.1016/j.cellimm.2020.104253  0.315
2020 Wardell CM, MacDonald KN, Levings MK, Cook L. Cross talk between human regulatory T cells and antigen presenting cells: Lessons for clinical applications. European Journal of Immunology. PMID 33301176 DOI: 10.1002/eji.202048746  0.502
2020 Wu D, Wong MQ, Vent-Schmidt J, Boardman DA, Steiner TS, Levings MK. A method for expansion and retroviral transduction of mouse regulatory T cells. Journal of Immunological Methods. 112931. PMID 33221458 DOI: 10.1016/j.jim.2020.112931  0.469
2020 Rosado-Sánchez I, Levings MK. Building a CAR-Treg: Going from the basic to the luxury model. Cellular Immunology. 358: 104220. PMID 33096321 DOI: 10.1016/j.cellimm.2020.104220  0.47
2020 Dawson NAJ, Rosado-Sánchez I, Novakovsky GE, Fung VCW, Huang Q, McIver E, Sun G, Gillies J, Speck M, Orban PC, Mojibian M, Levings MK. Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells. Science Translational Medicine. 12. PMID 32817364 DOI: 10.1126/Scitranslmed.Aaz3866  0.514
2020 Cook L, Levings MK. T-Cell Specificity Matters in IBD: Impaired IL10 Production Revealed by OmpC-Tetramers. Cellular and Molecular Gastroenterology and Hepatology. PMID 32645294 DOI: 10.1016/J.Jcmgh.2020.06.007  0.452
2020 Wu D, Wong CK, Han JM, Orban PC, Huang Q, Gillies J, Mojibian M, Gibson WT, Levings MK. T reg-specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome. The Journal of Experimental Medicine. 217. PMID 32478834 DOI: 10.1084/Jem.20191542  0.405
2020 Boardman DA, Garcia RV, Ivison SM, Bressler B, Dhar TM, Zhao Q, Levings MK. Pharmacological inhibition of RORC2 enhances human Th17-Treg stability and function. European Journal of Immunology. PMID 32388860 DOI: 10.1002/Eji.201948435  0.499
2020 Sicard A, Lamarche C, Speck M, Wong M, Rosado-Sánchez I, Blois M, Glaichenhaus N, Mojibian M, Levings MK. Donor-specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 31957209 DOI: 10.1111/Ajt.15787  0.407
2020 Dijke E, Ellis T, Larsen I, Rebeyka I, Freed D, Al-Aklabi M, Levings M, West L. Human Leukocyte Antigen (HLA) Class II Expression on Regulatory T Cells (Tregs) Isolated from Discarded Human Thymus is Induced by In Vitro Expansion Conditions The Journal of Heart and Lung Transplantation. 39: S178-S179. DOI: 10.1016/J.Healun.2020.01.755  0.431
2019 MacDonald KN, Ivison S, Hippen KL, Hoeppli RE, Hall M, Zheng G, Dijke IE, Aklabi MA, Freed DH, Rebeyka I, Gandhi S, West LJ, Piret JM, Blazar BR, Levings MK. Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol. Cytotherapy. PMID 31810768 DOI: 10.1016/J.Jcyt.2019.10.011  0.494
2019 Cook L, Lisko DJ, Wong MQ, Garcia RV, Himmel ME, Seidman EG, Bressler B, Levings MK, Steiner TS. Analysis of flagellin-specific adaptive immunity reveals links to dysbiosis in patients with Inflammatory Bowel Disease. Cellular and Molecular Gastroenterology and Hepatology. PMID 31790809 DOI: 10.1016/J.Jcmgh.2019.11.012  0.459
2019 Wu D, Huang Q, Orban PC, Levings MK. Ectopic germline recombination activity of the widely-used Foxp3-YFP-Cre mouse: a case-report. Immunology. PMID 31713233 DOI: 10.1111/Imm.13153  0.341
2019 Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, ... ... Levings MK, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). European Journal of Immunology. 49: 1457-1973. PMID 31633216 DOI: 10.1002/Eji.201970107  0.32
2019 Cook L, Stahl M, Han X, Nazli A, MacDonald KN, Wong MQ, Tsai K, Dizzell S, Jacobson K, Bressler B, Kaushic C, Vallance BA, Steiner TS, Levings MK. Suppressive and Gut Reparative Functions of Human Type 1 T-regulatory Cells. Gastroenterology. PMID 31513797 DOI: 10.1053/J.Gastro.2019.09.002  0.571
2019 Wu D, Levings MK. A New Mechanism of Action in Human and Mouse Treg Cells: The Ke(y)to Suppression. Immunity. 50: 1122-1124. PMID 31117006 DOI: 10.1016/J.Immuni.2019.04.008  0.508
2019 MacDonald KN, Piret JM, Levings MK. Methods to manufacture regulatory T cells for cell therapy. Clinical and Experimental Immunology. PMID 30913302 DOI: 10.1111/Cei.13297  0.458
2019 Lam AJ, MacDonald KN, Pesenacker AM, Juvet SC, Morishita KA, Bressler B, Pan JG, Sidhu SS, Rioux JD, Levings MK. Innate Control of Tissue-Reparative Human Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 30850479 DOI: 10.4049/Jimmunol.1801330  0.815
2019 Lad D, Huang Q, Hoeppli R, Garcia R, Xu L, Levings M, Song K, Broady R. Evaluating the role of Tregs in the progression of multiple myeloma. Leukemia & Lymphoma. 1-9. PMID 30773086 DOI: 10.1080/10428194.2019.1579324  0.532
2019 Dawson NA, Lamarche C, Hoeppli RE, Bergqvist P, Fung V, McIver E, Huang Q, Gillies J, Speck M, Orban PC, Bush JW, Mojibian M, Levings MK. Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in T regulatory cells. Jci Insight. PMID 30753169 DOI: 10.1172/Jci.Insight.123672  0.429
2019 Pesenacker AM, Chen V, Gillies J, Speake C, Marwaha AK, Sun AC, Chow S, Tan R, Elliott T, Dutz JP, Tebbutt SJ, Levings MK. Treg gene signatures predict and measure type 1 diabetes trajectory. Jci Insight. PMID 30730852 DOI: 10.1172/Jci.Insight.123879  0.312
2019 Dijke E, Ellis T, Larsen I, Rebeyka I, Freed D, Al Aklabi M, Levings M, West L. OR12 Expansion conditions affect human leukocyte antigens (HLA) Class II expression on thymic regulatory T cells (TREGS) Human Immunology. 80: 16. DOI: 10.1016/J.Humimm.2019.07.014  0.454
2018 Wu D, Han JM, Yu X, Lam AJ, Hoeppli RE, Pesenacker AM, Huang Q, Chen V, Speake C, Yorke E, Nguyen N, Sampath S, Harris D, Levings MK. Characterization of regulatory T cells in obese omental adipose tissue in humans. European Journal of Immunology. PMID 30566246 DOI: 10.1002/Eji.201847570  0.79
2018 Ivison S, Malek M, Garcia RV, Broady R, Halpin A, Richaud M, Brant RF, Wang SI, Goupil M, Guan Q, Ashton P, Warren J, Rajab A, Urschel S, Kumar D, ... ... Levings MK, et al. A standardized immune phenotyping and automated data analysis platform for multicenter biomarker studies. Jci Insight. 3. PMID 30518691 DOI: 10.1172/Jci.Insight.121867  0.322
2018 Sicard A, Boardman DA, Levings MK. Taking regulatory T-cell therapy one step further. Current Opinion in Organ Transplantation. 23: 509-515. PMID 30063480 DOI: 10.1097/Mot.0000000000000566  0.503
2018 Hoeppli RE, MacDonald KN, Leclair P, Fung VCW, Mojibian M, Gillies J, Rahavi SMR, Campbell AIM, Gandhi SK, Pesenacker AM, Reid G, Lim CJ, Levings MK. Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inflammation or intestinal regions. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 29766641 DOI: 10.1111/Ajt.14936  0.53
2018 Sicard A, Levings MK, Scott DW. Engineering Therapeutic T Cells to Suppress Alloimmune Responses Using TCRs, CARs or BARs. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 29603617 DOI: 10.1111/Ajt.14747  0.521
2018 Lamarche C, Levings MK. Guiding regulatory T cells to the allograft. Current Opinion in Organ Transplantation. 23: 106-113. PMID 29140829 DOI: 10.1097/Mot.0000000000000483  0.492
2018 Lam AJ, Huang H, Pan JG, Sidhu SS, Charron G, Ivison SM, Rioux JD, Levings MK. Human Regulatory T Cell Potential for Tissue Repair Via IL-33/ST2 and Amphiregulin Transplantation. 102. DOI: 10.1097/01.Tp.0000543061.12872.C0  0.803
2018 Alonso-Guallart P, Duran-Struuck R, Stern J, Berglund E, Llore N, Zitsman J, Pierre G, Kofman S, Danton M, Gokova S, Lopes E, McMurchy A, Tang Q, Levings M, Sykes M, et al. Megadose Bone Marrow and Regulatory T cells for the Induction of Immune Tolerance in Non-Human Primates Through Durable Mixed Hematopoietic Chimerism Across MHC-barriers Transplantation. 102: S263-S264. DOI: 10.1097/01.Tp.0000542954.80179.6B  0.473
2018 Dawson NAJ, Lamarche C, Bergqvist P, Huang Q, Mojibian M, Gillies J, Orban PC, Hoeppli R, Levings MK. Humanization and Pre-Clinical Validation of an Anti-HLA-A*02: 01 Chimeric Antigen Receptor for use with Regulatory T cells to Enhance Transplant Tolerance. Transplantation. 102. DOI: 10.1097/01.Tp.0000542905.98105.1F  0.464
2018 Bernaldo-de-Quiros E, Camino M, Gil-Jaurena JM, Fernández-Santos E, Gil N, Panadero E, Medrano C, López R, Martínez-Bonet M, Hernández-Flórez D, Levings MK, West LJ, Pion M, Correa-Rocha R. “First-In-Human” Clinical Trial Employing Adoptive Transfer of Autologous Thymus-Derived Treg Cells (thyTreg) to Prevent Graft Rejection in Heart-Transplanted Children Transplantation. 102. DOI: 10.1097/01.Tp.0000542859.38902.Af  0.325
2017 Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, ... ... Levings M, et al. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Frontiers in Immunology. 8: 1844. PMID 29379498 DOI: 10.3389/Fimmu.2017.01844  0.499
2017 Dawson NAJ, Vent-Schmidt J, Levings MK. Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells. Frontiers in Immunology. 8: 1460. PMID 29163527 DOI: 10.3389/Fimmu.2017.01460  0.56
2017 Ivison S, des Rosiers C, Lesage S, Rioux JD, Levings MK. Biomarker-guided stratification of autoimmune patients for biologic therapy. Current Opinion in Immunology. 49: 56-63. PMID 29053992 DOI: 10.1016/J.Coi.2017.09.006  0.321
2017 Cossarizza A, Chang HD, Radbruch A, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, ... ... Levings MK, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies. European Journal of Immunology. 47: 1584-1797. PMID 29023707 DOI: 10.1002/Eji.201646632  0.409
2017 Kariminia A, Ivison S, Ng B, Rozmus J, Sung S, Varshney A, Aljurf M, Lachance S, Walker I, Toze C, Lipton J, Lee SJ, Szer J, Doocey R, Lewis I, ... ... Levings MK, et al. CD56bright NK regulatory cells in filgrastim primed donor blood or marrow products regulate chronic GvHD: CBMTG randomized 0601 study results. Haematologica. PMID 28935847 DOI: 10.3324/Haematol.2017.170928  0.436
2017 Becker M, Levings MK, Daniel C. Adipose-tissue regulatory T cells: Critical players in adipose-immune crosstalk. European Journal of Immunology. PMID 28849586 DOI: 10.1002/Eji.201646739  0.506
2017 Dawson NAJ, Levings MK. Antigen-specific regulatory T cells: are police CARs the answer? Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 28688236 DOI: 10.1016/J.Trsl.2017.06.009  0.533
2017 Golec DP, Hoeppli RE, Henao Caviedes LM, McCann J, Levings MK, Baldwin TA. Thymic progenitors of TCRαβ(+) CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development. The Journal of Experimental Medicine. PMID 28652304 DOI: 10.1084/Jem.20170844  0.41
2017 Lad D, Hoeppli R, Huang Q, Garcia R, Xu L, Toze C, Broady R, Levings M. Regulatory T-cells drive immune dysfunction in CLL. Leukemia & Lymphoma. 1-4. PMID 28573905 DOI: 10.1080/10428194.2017.1330475  0.527
2017 Lam AJ, Hoeppli RE, Levings MK. Harnessing Advances in T Regulatory Cell Biology for Cellular Therapy in Transplantation. Transplantation. PMID 28376037 DOI: 10.1097/Tp.0000000000001757  0.811
2017 Cook L, Munier CM, Seddiki N, van Bockel D, Ontiveros N, Hardy MY, Gillies JK, Levings MK, Reid H, Peterson J, Rossjohn J, Anderson RP, Zaunders J, Tye-Din JA, Kelleher AD. Circulating Gluten-Specific FOXP3(+)CD39(+) Regulatory T Cells Have Impaired Suppressive Function in Celiac Disease. The Journal of Allergy and Clinical Immunology. PMID 28283419 DOI: 10.1016/J.Jaci.2017.02.015  0.543
2017 Hoeppli RE, Dijke E, Campbell A, West LJ, Levings MK. Migration Capacity of Thymic Regulatory T Cells can be Tuned by Expansion in Cytokine-Enriched Culture Conditions Transplantation. 101. DOI: 10.1097/01.Tp.0000520352.47820.13  0.472
2017 Quirós EBd, Pérez VA, Clemente M, Gil-Jaurena JM, González MT, Pion M, Lombardi G, West LJ, Levings M, Correa-Rocha R. Thymus-Derived Treg Infusion to Prevent Graft Rejection in Heart-Transplanted Children: Initial Exploration of a New Therapeutic Arsenal to Boost Immune Tolerance Transplantation. 101. DOI: 10.1097/01.Tp.0000520350.40197.6B  0.33
2017 MacDonald K, Hoeppli R, Piret J, Dijke E, West L, Levings M. Development of GMP-Compatible Protocols for Thymus-Derived Regulatory T Cell Expansion Transplantation. 101: S9. DOI: 10.1097/01.Tp.0000520303.10595.5E  0.495
2017 Cook L, Wong M, Rees W, Lau T, Levings M, Steiner T. CD4+ T Cells Specific for C. difficile Toxins are a Marker of Patients with Active Relapsing Disease Open Forum Infectious Diseases. 4. DOI: 10.1093/Ofid/Ofx163.948  0.436
2017 Cook L, Wong MQ, Garcia R, Himmel ME, Bressler B, Seidman EG, Steiner TS, Levings MK. A Novel Whole Blood Assay Detects Flagellin-Specific CD4 + T Cells in Patients with Inflammatory Bowel Disease Gastroenterology. 152: S615. DOI: 10.1016/S0016-5085(17)32185-6  0.439
2017 Dijke E, Hoeppli R, Larsen I, Rebeyka I, Ross D, Levings M, West L. OR42 Expanded thymic regulatory T cells (Tregs) have low class I HLA expression levels and are HLA-DR negative – Potential for ‘Off-The-Shelf’ Cellular Therapy? Human Immunology. 78: 40. DOI: 10.1016/J.Humimm.2017.06.048  0.488
2017 Lad D, Broady R, Huang J, Hoeppli R, Pesenacker A, Garcia R, Xu L, Levings M, Song K. Evaluating the Role of Tregs in the Progression of Multiple Myeloma Clinical Lymphoma, Myeloma & Leukemia. 17. DOI: 10.1016/J.Clml.2017.03.075  0.312
2016 Duran-Struuck R, Sondermeijer HP, Bühler L, Alonso-Guallart P, Zitsman J, Kato Y, Wu A, McMurchy AN, Woodland D, Griesemer A, Martinez M, Boskovic S, Kawai T, Cosimi AB, Wuu CS, ... ... Levings M, et al. Effect of ex vivo Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques. Transplantation. PMID 27846155 DOI: 10.1097/Tp.0000000000001559  0.509
2016 Pesenacker AM, Cook L, Levings MK. The role of FOXP3 in autoimmunity. Current Opinion in Immunology. 43: 16-23. PMID 27544816 DOI: 10.1016/J.Coi.2016.07.004  0.498
2016 Hoeppli RE, MacDonald KG, Levings MK, Cook L. How antigen specificity directs regulatory T-cell function: self, foreign and engineered specificity. Hla. PMID 27256587 DOI: 10.1111/tan.12822  0.432
2016 MacDonald KG, Hoeppli RE, Huang Q, Gillies J, Luciani DS, Orban PC, Broady R, Levings MK. Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. The Journal of Clinical Investigation. PMID 26999600 DOI: 10.1172/Jci82771  0.509
2016 Patterson SJ, Pesenacker AM, Wang AY, Gillies J, Mojibian M, Morishita K, Tan R, Kieffer TJ, Verchere CB, Panagiotopoulos C, Levings MK. T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression. The Journal of Clinical Investigation. PMID 26854929 DOI: 10.1172/Jci83987  0.548
2016 Pesenacker AM, Wang AY, Singh A, Gillies J, Kim YW, Piccirillo CA, Nguyen D, Haining WN, Tebbutt SJ, Panagiotopoulos C, Levings MK. A Treg gene signature is a specific and sensitive biomarker to identify children with new onset type 1 diabetes. Diabetes. PMID 26786322 DOI: 10.2337/Db15-0572  0.452
2016 Dijke E, Hoeppli R, Seeberger K, Larsen I, Rebeyka I, Ross D, Korbutt G, Levings M, West L. Allogeneic and Xenogeneic Immunity Is Potently Suppressed by Expanded Regulatory T Cells (Tregs) from Human Thymus Journal of Heart and Lung Transplantation. 35. DOI: 10.1016/J.Healun.2016.01.521  0.577
2015 Weiner J, Duran-Struuck R, Zitsman J, Buhler L, Sondermeijer H, McMurchy AN, Levings MK, Sykes M, Griesemer A. Restimulation After Cryopreservation and Thawing Preserves the Phenotype and Function of Expanded Baboon Regulatory T Cells. Transplantation Direct. 1: 1-7. PMID 27019869 DOI: 10.1097/Txd.0000000000000511  0.527
2015 Dijke IE, Hoeppli RE, Ellis T, Pearcey J, Huang Q, McMurchy AN, Boer K, Peeters AM, Aubert G, Larsen I, Ross DB, Rebeyka I, Campbell A, Baan CC, Levings MK, et al. Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 26414799 DOI: 10.1111/Ajt.13456  0.576
2015 Yao Y, Vent-Schmidt J, McGeough MD, Wong M, Hoffman HM, Steiner TS, Levings MK. Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism. Journal of Immunology (Baltimore, Md. : 1950). 195: 488-97. PMID 26056255 DOI: 10.4049/Jimmunol.1403225  0.526
2015 Han JM, Wu D, Denroche HC, Yao Y, Verchere CB, Levings MK. IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance. Journal of Immunology (Baltimore, Md. : 1950). 194: 4777-83. PMID 25870243 DOI: 10.4049/Jimmunol.1500020  0.405
2015 Hoeppli RE, Wu D, Cook L, Levings MK. The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome. Frontiers in Immunology. 6: 61. PMID 25741338 DOI: 10.3389/Fimmu.2015.00061  0.553
2015 MacDonald KG, Dawson NA, Huang Q, Dunne JV, Levings MK, Broady R. Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis. The Journal of Allergy and Clinical Immunology. 135: 946-.e9. PMID 25678090 DOI: 10.1016/J.Jaci.2014.12.1932  0.529
2015 Pesenacker AM, Broady R, Levings MK. Control of tissue-localized immune responses by human regulatory T cells. European Journal of Immunology. 45: 333-43. PMID 25378065 DOI: 10.1002/Eji.201344205  0.545
2015 Dijke E, Hoeppli R, Ellis T, Pearcey J, Larsen I, Rebeyka I, Ross D, Levings M, West L. Rapamycin Enhances the Suppressive Capacity of Ex Vivo Expanded Regulatory T Cells (Tregs) Isolated From Pediatric Thymus Journal of Heart and Lung Transplantation. 34. DOI: 10.1016/J.Healun.2015.01.397  0.517
2015 Guallart PA, Zitsman J, Sondermeijer H, Bühler L, Ovanez C, McMurchy A, Levings M, Sykes M, Duran-Struuck R. Phenotype, Function and Expansion of Regulatory T Cells in the Cynomolgus Macaque (Macaca fascicularis) Biology of Blood and Marrow Transplantation. 21: S280-S281. DOI: 10.1016/J.Bbmt.2014.11.445  0.514
2015 Guallart PA, Zitsman J, Sondermeijer H, Woodland D, Kato Y, Weiner J, Griesemer A, Bühler L, McMurchy A, Levings M, Sykes M, Duran-Struuck R. Induction of Durable Mixed Hematopoietic Chimerism and Immune Tolerance in Monkeys Biology of Blood and Marrow Transplantation. 21: S46-S47. DOI: 10.1016/J.Bbmt.2014.11.040  0.358
2014 Antignano F, Burrows K, Hughes MR, Han JM, Kron KJ, Penrod NM, Oudhoff MJ, Wang SK, Min PH, Gold MJ, Chenery AL, Braam MJ, Fung TC, Rossi FM, McNagny KM, ... ... Levings MK, et al. Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation. The Journal of Clinical Investigation. 124: 1945-55. PMID 24667637 DOI: 10.1172/Jci69592  0.507
2014 Han JM, Patterson SJ, Speck M, Ehses JA, Levings MK. Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity. Journal of Immunology (Baltimore, Md. : 1950). 192: 623-9. PMID 24323581 DOI: 10.4049/Jimmunol.1302181  0.414
2014 Vent-Schmidt J, Han JM, MacDonald KG, Levings MK. The role of FOXP3 in regulating immune responses. International Reviews of Immunology. 33: 110-28. PMID 23947341 DOI: 10.3109/08830185.2013.811657  0.47
2014 Dijke E, McMurchy A, Ellis T, Boer K, Larsen I, Rebeyka I, Ross D, Baan C, Levings M, West L. Pediatric Thymic Tissue as a Novel Source for the Expansion of Stable Regulatory T Cells for Cellular Therapy.: Abstract# 2273 Transplantation. 98: 43. DOI: 10.1097/00007890-201407151-00144  0.46
2014 Dijke E, McMurchy A, Ellis T, Boer K, Larsen I, Rebeyka I, Ross D, Baan C, Levings M, West L. Expanded Thymic CD25+FOXP3+ Regulatory T Cells (Tregs) Maintain Stable Function and Phenotype Under Inflammatory Conditions - Potential for Cellular Therapy? Journal of Heart and Lung Transplantation. 33. DOI: 10.1016/J.Healun.2014.01.104  0.516
2013 Han JM, Levings MK. Immune regulation in obesity-associated adipose inflammation. Journal of Immunology (Baltimore, Md. : 1950). 191: 527-32. PMID 23825387 DOI: 10.4049/Jimmunol.1301035  0.349
2013 MacDonald KG, Han JM, Himmel ME, Huang Q, Kan B, Campbell AI, Lavoie PM, Levings MK. Response to comment on "helios+ and helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans". Journal of Immunology (Baltimore, Md. : 1950). 190: 4440-1. PMID 23606719 DOI: 10.4049/Jimmunol.1390019  0.458
2013 Himmel ME, MacDonald KG, Garcia RV, Steiner TS, Levings MK. Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans. Journal of Immunology (Baltimore, Md. : 1950). 190: 2001-8. PMID 23359504 DOI: 10.4049/Jimmunol.1201379  0.556
2013 McMurchy AN, Levings MK. In vitro generation of human T regulatory cells: generation, culture, and analysis of FOXP3-transduced T cells. Methods in Molecular Biology (Clifton, N.J.). 946: 115-32. PMID 23179829 DOI: 10.1007/978-1-62703-128-8_8  0.618
2013 McMurchy AN, Gillies J, Gizzi MC, Riba M, Garcia-Manteiga JM, Cittaro D, Lazarevic D, Di Nunzio S, Piras IS, Bulfone A, Roncarolo MG, Stupka E, Bacchetta R, Levings MK. A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells. Blood. 121: 1265-75. PMID 23169781 DOI: 10.1182/Blood-2012-05-431023  0.563
2013 Battaglia M, Bacchetta R, Levings M, Gregori S. T-Cell-Mediated Suppression: From Bench to Bedside Blood. 122. DOI: 10.1182/Blood.V122.21.Sci-37.Sci-37  0.618
2013 Prestidge T, Davis J, Huang J, Himmel M, Levings M. Autologous transplant for autoimmune disease: optimizing the regulatory T cells Cytotherapy. 15: S42-S43. DOI: 10.1016/J.Jcyt.2013.01.161  0.462
2013 Dijke E, Levings M, McMurchy A, Larsen I, Rebeyka I, Ross D, West L. Pediatric thymic tissue as a source of CD25+FOXP3+ regulatory T cells (Tregs) for cellular therapy Cytotherapy. 15. DOI: 10.1016/J.Jcyt.2013.01.160  0.493
2013 Dijke E, McMurchy A, Levings M, Larsen I, Rebeyka I, Ross D, West L. Pediatric Thymic Tissue as a Source of Regulatory T Cells for Cellular Therapy Journal of Heart and Lung Transplantation. 32. DOI: 10.1016/J.Healun.2013.01.982  0.495
2012 Yao Y, Levings MK, Steiner TS. ATP conditions intestinal epithelial cells to an inflammatory state that promotes components of DC maturation. European Journal of Immunology. 42: 3310-21. PMID 22987503 DOI: 10.1002/Eji.201142213  0.459
2012 Han JM, Patterson SJ, Levings MK. The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function. Frontiers in Immunology. 3: 245. PMID 22905034 DOI: 10.3389/Fimmu.2012.00245  0.549
2012 MacDonald KG, Orban PC, Levings MK. T regulatory cell therapy in transplantation: stability, localization and functional specialization. Current Opinion in Organ Transplantation. 17: 343-8. PMID 22790068 DOI: 10.1097/Mot.0B013E328355Aaaf  0.534
2012 Marwaha AK, Leung NJ, McMurchy AN, Levings MK. TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? Frontiers in Immunology. 3: 129. PMID 22675324 DOI: 10.3389/Fimmu.2012.00129  0.486
2012 Yurchenko E, Shio MT, Huang TC, Da Silva Martins M, Szyf M, Levings MK, Olivier M, Piccirillo CA. Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. Plos One. 7: e35572. PMID 22545118 DOI: 10.1371/Journal.Pone.0035572  0.604
2012 Himmel ME, Yao Y, Orban PC, Steiner TS, Levings MK. Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers. Immunology. 136: 115-22. PMID 22348589 DOI: 10.1111/J.1365-2567.2012.03572.X  0.473
2012 McMurchy AN, Levings MK. Suppression assays with human T regulatory cells: a technical guide. European Journal of Immunology. 42: 27-34. PMID 22161814 DOI: 10.1002/Eji.201141651  0.6
2012 Hardenberg G, Yao Y, Piccirillo CA, Levings MK, Steiner TS. Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient mice. Inflammatory Bowel Diseases. 18: 85-93. PMID 22038840 DOI: 10.1002/Ibd.21738  0.544
2012 Ivison S, Kariminia A, Levings M, Broady R, Panzarella T, Albert-Green A, Aljurf M, Al Humaidan H, Foley R, Devins G, Kerr HM, Lee SJ, Swajcer D, Toze CL, Couban S, et al. Higher Proportions of IFNg-Producing T Cells, CD56bright NK Cells and Immature B Cells in the Lymphocytes of G-CSF Stimulated Donor Grafts Are Associated with Less Chronic Gvhd After HSCT: Results From the Canadian BMT Group 0601 Randomized, Phase III Trial Blood. 120: 1944-1944. DOI: 10.1182/Blood.V120.21.1944.1944  0.449
2012 Dijke E, McMurchy A, Levings M, Larsen I, Rebeyka I, Ross D, West L. Expansion of Highly Suppressive FOXP3+ Regulatory T Cells from Pediatric Thymic Tissue: 2239 Transplantation. 94: 1193. DOI: 10.1097/00007890-201211271-00661  0.51
2012 Montane J, Obach M, Bischoff L, Soukhatcheva G, Orban PC, Hardenberg G, Levings MK, Tan R, Verchere CB. Chemokine Induced Tolerance in Mouse Islet Allografts Canadian Journal of Diabetes. 36. DOI: 10.1016/J.Jcjd.2012.07.468  0.344
2011 Cohen CJ, Crome SQ, MacDonald KG, Dai EL, Mager DL, Levings MK. Human Th1 and Th17 cells exhibit epigenetic stability at signature cytokine and transcription factor loci. Journal of Immunology (Baltimore, Md. : 1950). 187: 5615-26. PMID 22048764 DOI: 10.4049/Jimmunol.1101058  0.46
2011 Yurchenko E, Levings MK, Piccirillo CA. CD4+ Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammation. European Journal of Immunology. 41: 3455-66. PMID 21956668 DOI: 10.1002/Eji.201141814  0.571
2011 Zhang X, de Chickera SN, Willert C, Economopoulos V, Noad J, Rohani R, Wang AY, Levings MK, Scheid E, Foley R, Foster PJ, Dekaban GA. Cellular magnetic resonance imaging of monocyte-derived dendritic cell migration from healthy donors and cancer patients as assessed in a scid mouse model. Cytotherapy. 13: 1234-48. PMID 21923625 DOI: 10.3109/14653249.2011.605349  0.329
2011 Assi K, Patterson S, Dedhar S, Owen D, Levings M, Salh B. Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire. Bmc Immunology. 12: 42. PMID 21806815 DOI: 10.1186/1471-2172-12-42  0.362
2011 Antignano F, Hamilton M, Patterson S, Ho V, Cohen C, Levings MK, Krystal G. SHIP-deficient dendritic cells, unlike wild type dendritic cells, suppress T cell proliferation via a nitric oxide-independent mechanism. Plos One. 6: e21893. PMID 21755007 DOI: 10.1371/Journal.Pone.0021893  0.475
2011 Montane J, Bischoff L, Soukhatcheva G, Dai DL, Hardenberg G, Levings MK, Orban PC, Kieffer TJ, Tan R, Verchere CB. Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets. The Journal of Clinical Investigation. 121: 3024-8. PMID 21737880 DOI: 10.1172/Jci43048  0.499
2011 McMurchy AN, Bushell A, Levings MK, Wood KJ. Moving to tolerance: clinical application of T regulatory cells. Seminars in Immunology. 23: 304-13. PMID 21620722 DOI: 10.1016/J.Smim.2011.04.001  0.501
2011 Patterson SJ, Han JM, Garcia R, Assi K, Gao T, O'Neill A, Newton AC, Levings MK. Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 186: 5533-7. PMID 21498666 DOI: 10.4049/Jimmunol.1002126  0.473
2011 Hardenberg G, Steiner TS, Levings MK. Environmental influences on T regulatory cells in inflammatory bowel disease. Seminars in Immunology. 23: 130-8. PMID 21295492 DOI: 10.1016/J.Smim.2011.01.012  0.543
2011 Himmel ME, Crome SQ, Ivison S, Piccirillo C, Steiner TS, Levings MK. Human CD4+ FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils. European Journal of Immunology. 41: 306-12. PMID 21268001 DOI: 10.1002/Eji.201040459  0.568
2011 Wang AY, Crome SQ, Jenkins KM, Medin JA, Bramson JL, Levings MK. Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production. Cancer Immunology, Immunotherapy : Cii. 60: 381-8. PMID 21153637 DOI: 10.1007/S00262-010-0948-4  0.479
2011 Ivison SM, Himmel ME, Mayer M, Yao Y, Kifayet A, Levings MK, Steiner TS. The stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells. Inflammatory Bowel Diseases. 17: 319-33. PMID 20722064 DOI: 10.1002/Ibd.21428  0.34
2011 Assi K, Patterson S, Owen DA, Dedhar S, Levings MK, Salh B. Integrin-Linked Kinase Promotes Colitis Through Regulation of CCL2, Fibronectin and Regulatory T Cells Gastroenterology. 140: S-636. DOI: 10.1016/S0016-5085(11)62632-2  0.462
2011 Yao Y, Steiner TS, Levings MK. The Stress Signal Extracellular ATP Modulates Immune Responses in Intestinal Epithelial Cells and Influences Dendritic Cell Maturation Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)62627-9  0.376
2011 Wang AY, Levings MK. T regulatory cells and cancer immunotherapy Experimental and Applied Immunotherapy. 207-228. DOI: 10.1007/978-1-60761-980-2_10  0.451
2010 McMurchy AN, Gillies J, Allan SE, Passerini L, Gambineri E, Roncarolo MG, Bacchetta R, Levings MK. Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells. The Journal of Allergy and Clinical Immunology. 126: 1242-51. PMID 21036387 DOI: 10.1016/J.Jaci.2010.09.001  0.484
2010 Silverman JM, Clos J, Horakova E, Wang AY, Wiesgigl M, Kelly I, Lynn MA, McMaster WR, Foster LJ, Levings MK, Reiner NE. Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 185: 5011-22. PMID 20881185 DOI: 10.4049/Jimmunol.1000541  0.464
2010 Broady R, Yu J, Chow V, Tantiworawit A, Kang C, Berg K, Martinka M, Ghoreishi M, Dutz J, Levings MK. Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells. Blood. 116: 5748-51. PMID 20864580 DOI: 10.1182/Blood-2010-07-295436  0.454
2010 Marwaha AK, Crome SQ, Panagiotopoulos C, Berg KB, Qin H, Ouyang Q, Xu L, Priatel JJ, Levings MK, Tan R. Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes. Journal of Immunology (Baltimore, Md. : 1950). 185: 3814-8. PMID 20810982 DOI: 10.4049/Jimmunol.1001860  0.537
2010 Crome SQ, Clive B, Wang AY, Kang CY, Chow V, Yu J, Lai A, Ghahary A, Broady R, Levings MK. Inflammatory effects of ex vivo human Th17 cells are suppressed by regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 185: 3199-208. PMID 20720207 DOI: 10.4049/Jimmunol.1000557  0.567
2010 Ladd M, Sharma A, Huang Q, Wang AY, Xu L, Genowati I, Levings MK, Lavoie PM. Natural killer T cells constitutively expressing the interleukin-2 receptor α chain early in life are primed to respond to lower antigenic stimulation. Immunology. 131: 289-99. PMID 20545784 DOI: 10.1111/J.1365-2567.2010.03304.X  0.544
2010 Maggi L, Santarlasci V, Capone M, Peired A, Frosali F, Crome SQ, Querci V, Fambrini M, Liotta F, Levings MK, Maggi E, Cosmi L, Romagnani S, Annunziato F. CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC. European Journal of Immunology. 40: 2174-81. PMID 20486123 DOI: 10.1002/Eji.200940257  0.424
2010 Crome SQ, Wang AY, Levings MK. Translational mini-review series on Th17 cells: Function and regulation of human T helper 17 cells in health and disease Clinical and Experimental Immunology. 159: 109-119. PMID 19912252 DOI: 10.1111/J.1365-2249.2009.04037.X  0.563
2010 Ivison SM, Himmel ME, Hardenberg G, Wark PA, Kifayet A, Levings MK, Steiner TS. TLR5 is not required for flagellin-mediated exacerbation of DSS colitis. Inflammatory Bowel Diseases. 16: 401-9. PMID 19774646 DOI: 10.1002/Ibd.21097  0.434
2010 Montane J, Bischoff L, Soukhatcheva G, Hardenberg G, Levings MK, Tan R, Verchere CB. T Regulatory Cell Mediated Protection Of Allograft In Type 1 Diabetes: 2628 Transplantation. 90: 371. DOI: 10.1097/00007890-201007272-00686  0.422
2010 Himmel M, Crome S, Ivison S, Steiner T, Levings MK. Human Cd4+Foxp3+ T Regulatory Cells Produce Cxcl8 And Recruit Inflammatory Immune Cells: 3112 Transplantation. 90: 56. DOI: 10.1097/00007890-201007272-00108  0.568
2010 McMurchy A, Dai D, Gillies J, Verchere CB, Levings MK. Generation Of Human T Regulatory Cells With The Capacity To Suppress Islet Allograft Rejection In A Xenogeneic Mouse Model.: 673 Transplantation. 90: 8. DOI: 10.1097/00007890-201007272-00016  0.521
2010 Marwaha A, Levings M, Crome S, Panagiotopoulos C, Priatel J, Tan R. S.76Increased Fraction of IL-17 Secreting Cells in Type 1 Diabetes Clinical Immunology. 135. DOI: 10.1016/J.Clim.2010.03.398  0.316
2010 Crome S, Clive B, Wang A, Kang C, Chow V, Yiu J, Broady R, Levings M. The Inflammatory Effects of ex vivo Human T Helper 17 Cells are Suppressed by T Regulatory Cells Clinical Immunology. 135. DOI: 10.1016/J.Clim.2010.03.361  0.545
2010 Patterson S, Garcia R, O'Neill A, Gao T, Newton A, Levings M. PHLPP Regulates the Development, Function and Molecular Signaling Pathways of T Regulatory Cells Clinical Immunology. 135: S6. DOI: 10.1016/J.Clim.2010.03.025  0.441
2010 Broady R, Yu J, Chow V, Tantiworiwat A, Kang C, Berg K, Levings M. Patients With Cutaneous Graft Versus Host Disease Exhibit Reduced Production Of IL-17 Biology of Blood and Marrow Transplantation. 16. DOI: 10.1016/J.Bbmt.2009.12.456  0.309
2009 McMurchy AN, Levings MK. 3rd Keystone Symposium on T regulatory cells. Immunotherapy. 1: 529-37. PMID 20635985 DOI: 10.2217/Imt.09.33  0.519
2009 McMurchy AN, Di Nunzio S, Roncarolo MG, Bacchetta R, Levings MK. Molecular regulation of cellular immunity by FOXP3. Advances in Experimental Medicine and Biology. 665: 30-46. PMID 20429414 DOI: 10.1007/978-1-4419-1599-3_3  0.525
2009 Broady R, Yu J, Levings MK. ATG-induced expression of FOXP3 in human CD4(+) T cells in vitro is associated with T-cell activation and not the induction of FOXP3(+) T regulatory cells. Blood. 114: 5003-6. PMID 19822903 DOI: 10.1182/Blood-2009-04-214437  0.573
2009 Levings MK, Thomson AW. MASTering Treg function to promote tolerance. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 9: 2209-10. PMID 19764946 DOI: 10.1111/J.1600-6143.2009.02810.X  0.359
2009 Di Nunzio S, Cecconi M, Passerini L, McMurchy AN, Baron U, Turbachova I, Vignola S, Valencic E, Tommasini A, Junker A, Cazzola G, Olek S, Levings MK, Perroni L, Roncarolo MG, et al. Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations. Blood. 114: 4138-41. PMID 19738030 DOI: 10.1182/Blood-2009-04-214593  0.493
2009 Locke NR, Patterson SJ, Hamilton MJ, Sly LM, Krystal G, Levings MK. SHIP regulates the reciprocal development of T regulatory and Th17 cells Journal of Immunology. 183: 975-983. PMID 19542365 DOI: 10.4049/Jimmunol.0803749  0.547
2009 Crome SQ, Wang AY, Kang CY, Levings MK. The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells European Journal of Immunology. 39: 1480-1493. PMID 19449310 DOI: 10.1002/Eji.200838908  0.504
2008 Allan SE, Song-Zhao GX, Abraham T, McMurchy AN, Levings MK. Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3. European Journal of Immunology. 38: 3282-9. PMID 19039775 DOI: 10.1002/Eji.200838373  0.568
2008 Broady R, Levings MK. Graft-versus-host disease: suppression by statins. Nature Medicine. 14: 1155-6. PMID 18989280 DOI: 10.1038/Nm1108-1155  0.308
2008 Himmel ME, Hardenberg G, Piccirillo CA, Steiner TS, Levings MK. The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunology. 125: 145-53. PMID 18798918 DOI: 10.1111/J.1365-2567.2008.02939.X  0.54
2008 Allan SE, Broady R, Gregori S, Himmel ME, Locke N, Roncarolo MG, Bacchetta R, Levings MK. CD4+ T-regulatory cells: toward therapy for human diseases. Immunological Reviews. 223: 391-421. PMID 18613849 DOI: 10.1111/J.1600-065X.2008.00634.X  0.581
2008 Broady R, Yu J, Levings MK. Pro-tolerogenic effects of photodynamic therapy with TH9402 on dendritic cells. Journal of Clinical Apheresis. 23: 82-91. PMID 18381757 DOI: 10.1002/Jca.20162  0.491
2008 Passerini L, Allan SE, Battaglia M, Di Nunzio S, Alstad AN, Levings MK, Roncarolo MG, Bacchetta R. STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells. International Immunology. 20: 421-31. PMID 18270368 DOI: 10.1093/Intimm/Dxn002  0.516
2008 Allan SE, Alstad AN, Merindol N, Crellin NK, Amendola M, Bacchetta R, Naldini L, Roncarolo MG, Soudeyns H, Levings MK. Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 194-202. PMID 17984976 DOI: 10.1038/Sj.Mt.6300341  0.591
2008 Broady R, Crome SQ, Yu J, Dutz JP, Levings MK. Development of a Modified Skin Explant Assay to Study Treg Suppression of Th17 Cell Mediated GvHD in the Skin Blood. 112: 5434-5434. DOI: 10.1182/Blood.V112.11.5434.5434  0.597
2008 Bacchetta R, Nunzio SD, Perroni LB, Passerini L, Allan S, Alstad A, Junker A, Levings M, Roncarolo MG. F.75. Molecular and Functional Studies in T Cells from Healthy Carriers of FOXP3 Mutations Clinical Immunology. 127. DOI: 10.1016/J.Clim.2008.03.187  0.377
2008 Crome S, Wang A, Levings M. Expression of RORC2 Controls the Development of Human Th17 Cells Clinical Immunology. 127. DOI: 10.1016/J.Clim.2008.03.043  0.42
2007 Gregori S, Bacchetta R, Passerini L, Levings MK, Roncarolo MG. Isolation, expansion, and characterization of human natural and adaptive regulatory T cells. Methods in Molecular Biology (Clifton, N.J.). 380: 83-105. PMID 17876089 DOI: 10.1007/978-1-59745-395-0_6  0.596
2007 Crellin NK, Garcia RV, Levings MK. Flow cytometry-based methods for studying signaling in human CD4+CD25+FOXP3+ T regulatory cells. Journal of Immunological Methods. 324: 92-104. PMID 17582431 DOI: 10.1016/J.Jim.2007.05.008  0.567
2007 Allan SE, Crome SQ, Crellin NK, Passerini L, Steiner TS, Bacchetta R, Roncarolo MG, Levings MK. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. International Immunology. 19: 345-54. PMID 17329235 DOI: 10.1093/Intimm/Dxm014  0.571
2007 Crellin NK, Garcia RV, Levings MK. Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells. Blood. 109: 2014-2022. PMID 17062729 DOI: 10.1182/Blood-2006-07-035279  0.47
2007 Crome SQ, Wang A, Levings MK. 27 Effects of IL-17 On Effector and Regultory T Cell Subsets Cytokine. 39: 8-8. DOI: 10.1016/J.Cyto.2007.07.032  0.48
2006 Levings MK, Allan S, d'Hennezel E, Piccirillo CA. Functional dynamics of naturally occurring regulatory T cells in health and autoimmunity. Advances in Immunology. 92: 119-155. PMID 17145303 DOI: 10.1016/S0065-2776(06)92003-3  0.537
2006 Gianfrani C, Levings MK, Sartirana C, Mazzarella G, Barba G, Zanzi D, Camarca A, Iaquinto G, Giardullo N, Auricchio S, Troncone R, Roncarolo MG. Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells. Journal of Immunology (Baltimore, Md. : 1950). 177: 4178-86. PMID 16951383 DOI: 10.4049/Jimmunol.177.6.4178  0.549
2006 Roncarolo MG, Gregori S, Battaglia M, Bacchetta R, Fleischhauer K, Levings MK. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunological Reviews. 212: 28-50. PMID 16903904 DOI: 10.1111/J.0105-2896.2006.00420.X  0.582
2006 Bacchetta R, Passerini L, Gambineri E, Dai M, Allan SE, Perroni L, Dagna-Bricarelli F, Sartirana C, Matthes-Martin S, Lawitschka A, Azzari C, Ziegler SF, Levings MK, Roncarolo MG. Defective regulatory and effector T cell functions in patients with FOXP3 mutations. The Journal of Clinical Investigation. 116: 1713-22. PMID 16741580 DOI: 10.1172/Jci25112  0.531
2006 Roncarolo MG, Gregori S, Battaglia M, Bacchetta R, Fleischhauer K, Levings MK. Erratum: Interleukin-10- secreting type 1 regulatory T cells in rodents and humans (Immunological Reviews (2006) 212, (28-50)) Immunological Reviews. 213. DOI: 10.1111/J.1600-065X.2006.00448.X  0.513
2006 Allan S, Passerini L, Bacchetta R, Amendola M, Naldini L, Roncarolo MG, Levings M. Su.98. Defining a Role for FOXP3 in Human Cd4+ T-Cells Clinical Immunology. 119. DOI: 10.1016/J.Clim.2006.04.525  0.513
2006 Bacchetta R, Passerini L, Gambineri E, Allan S, Perroni L, Matthes-Martin S, Lawitschka A, Ziegler S, Levings M, Roncarolo MG. OR.40. Foxp3 Mutations in Children: Different Degrees of Impairment in Regulatory and Effector T-Cell Functions in Patients with Distinct Genotypes and Phenotypes Clinical Immunology. 119. DOI: 10.1016/J.Clim.2006.04.196  0.392
2006 Crellin N, Garcia R, Levings M. OR.7. Human CD4+CD25+ T Regulatory Cells Have Altered PKB Signalling Which Correlates with Suppressive Function Clinical Immunology. 119. DOI: 10.1016/J.Clim.2006.04.009  0.447
2005 Crellin NK, Garcia RV, Hadisfar O, Allan SE, Steiner TS, Levings MK. Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells. Journal of Immunology. 175: 8051-8059. PMID 16339542 DOI: 10.4049/Jimmunol.175.12.8051  0.513
2005 Allan SE, Passerini L, Bacchetta R, Crellin N, Dai M, Orban PC, Ziegler SF, Roncarolo MG, Levings MK. The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. The Journal of Clinical Investigation. 115: 3276-84. PMID 16211090 DOI: 10.1172/Jci24685  0.47
2005 Levings MK, Roncarolo MG. Phenotypic and functional differences between human CD4+CD25+ and type 1 regulatory T cells. Current Topics in Microbiology and Immunology. 293: 303-326. PMID 15981486 DOI: 10.1007/3-540-27702-1_14  0.502
2005 Salvati VM, Mazzarella G, Gianfrani C, Levings MK, Stefanile R, De Giulio B, Iaquinto G, Giardullo N, Auricchio S, Roncarolo MG, Troncone R. Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa. Gut. 54: 46-53. PMID 15591503 DOI: 10.1136/Gut.2003.023150  0.488
2005 Levings MK, Gregori S, Tresoldi E, Cazzaniga S, Bonini C, Roncarolo MG. Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells. Blood. 105: 1162-1169. PMID 15479730 DOI: 10.1182/Blood-2004-03-1211  0.581
2005 Guilbault B, Fairhurst M, Crellin N, Levings MK, Eaves AC, Thomas TE. A Simple Two-Step Method for the Isolation of Human CD4 + CD25 +bright / FOXP3 + Regulatory T Cells Directly from Whole Blood. Blood. 106: 2382-2382. DOI: 10.1182/Blood.V106.11.2382.2382  0.446
2004 Roncarolo MG, Gregori S, Levings M. Type 1 T regulatory cells and their relationship with CD4+CD25+ T regulatory cells. Novartis Foundation Symposium. 252: 115-27; discussion 1. PMID 14609215  0.498
2003 Roncarolo MG, Gregori S, Levings M. Type 1 T regulatory cells and their relationship with CD4+CD25+ T regulatory cells. Novartis Foundation Symposium. 252: 115-131. DOI: 10.1002/0470871628.Ch9  0.579
2002 Levings MK, Bacchetta R, Schulz U, Roncarolo MG. The Role of IL-10 and TGF-β in the Differentiation and Effector Function of T Regulatory Cells International Archives of Allergy and Immunology. 129: 263-276. PMID 12483031 DOI: 10.1159/000067596  0.547
2002 Levings MK, Sangregorio R, Sartirana C, Moschin AL, Battaglia M, Orban PC, Roncarolo M. Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells Journal of Experimental Medicine. 196: 1335-1346. PMID 12438424 DOI: 10.1084/Jem.20021139  0.51
2002 Bacchetta R, Sartirana C, Levings MK, Bordignon C, Narula S, Roncarolo M. Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines. European Journal of Immunology. 32: 2237-2245. PMID 12209636 DOI: 10.1002/1521-4141(200208)32:8<2237::Aid-Immu2237>3.0.Co;2-2  0.459
2001 Roncarolo MG, Bacchetta R, Bordignon C, Narula S, Levings MK. Type 1 T regulatory cells. Immunological Reviews. 182: 68-79. PMID 11722624 DOI: 10.1034/J.1600-065X.2001.1820105.X  0.537
2001 Levings MK, Sangregorio R, Roncarolo M. Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function Journal of Experimental Medicine. 193: 1295-1302. PMID 11390436 DOI: 10.1084/Jem.193.11.1295  0.499
2001 Levings MK, Sangregorio R, Galbiati F, Squadrone S, Malefyt RdW, Roncarolo M. IFN-α and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells Journal of Immunology. 166: 5530-5539. PMID 11313392 DOI: 10.4049/Jimmunol.166.9.5530  0.535
2001 Roncarolo MG, Levings MK, Traversari C. Differentiation of T Regulatory Cells by Immature Dendritic Cells Journal of Experimental Medicine. 193. PMID 11208869 DOI: 10.1084/Jem.193.2.F5  0.456
2000 Roncarolo MG, Levings MK. The role of different subsets of T regulatory cells in controlling autoimmunity. Current Opinion in Immunology. 12: 676-683. PMID 11102772 DOI: 10.1016/S0952-7915(00)00162-X  0.546
2000 Levings MK, Roncarolo M. T-regulatory 1 cells: A novel subset of CD4+ T cells with immunoregulatory properties The Journal of Allergy and Clinical Immunology. 106. PMID 10887343 DOI: 10.1067/Mai.2000.106635  0.587
1999 Levings MK, Bessette DC, Schrader JW. Interleukin-4 synergizes with Raf-1 to promote long-term proliferation and activation of c-jun N-terminal kinase Blood. 93: 3694-3702. PMID 10339476 DOI: 10.1182/Blood.V93.11.3694.411A33_3694_3702  0.338
1997 Welham MJ, Bone H, Levings M, Learmonth L, Wang LM, Leslie KB, Pierce JH, Schrader JW. Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells Journal of Biological Chemistry. 272: 1377-1381. PMID 8995447 DOI: 10.1074/Jbc.272.2.1377  0.36
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