| Year |
Citation |
Score |
| 2024 |
Chery-Karschney L, Patrapuvich R, Mudeppa DG, Kokkonda S, Chakrabarti R, Sriwichai P, O'Connor RM, Rathod PK, White J. Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual . Antimicrobial Agents and Chemotherapy. e0068423. PMID 38193705 DOI: 10.1128/aac.00684-23 |
0.636 |
|
| 2022 |
Russo TA, Umland TC, Deng X, El Mazouni F, Kokkonda S, Olson R, Carlino-MacDonald U, Beanan J, Alvarado CL, Tomchick DR, Hutson A, Chen H, Posner B, Rathod PK, Charman SA, et al. Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant . Proceedings of the National Academy of Sciences of the United States of America. 119: e2213116119. PMID 36512492 DOI: 10.1073/pnas.2213116119 |
0.693 |
|
| 2021 |
Tan S, Mudeppa DG, Kokkonda S, White J, Patrapuvich R, Rathod PK. Properties of with a deleted apicoplast DNA gyrase. Antimicrobial Agents and Chemotherapy. AAC0058621. PMID 34152814 DOI: 10.1128/AAC.00586-21 |
0.741 |
|
| 2021 |
Palmer MJ, Deng X, Watts S, Krilov G, Gerasyuto A, Kokkonda S, El Mazouni F, White J, White KL, Striepen J, Bath J, Schindler KA, Yeo T, Shackleford DM, Mok S, et al. Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. Journal of Medicinal Chemistry. PMID 33876936 DOI: 10.1021/acs.jmedchem.1c00173 |
0.77 |
|
| 2020 |
Kokkonda S, Deng X, White KL, El Mazouni F, White J, Shackleford DM, Katneni K, Chiu FCK, Barker H, McLaren J, Crighton E, Chen G, Angulo-Barturen I, Jimenez-Diaz MB, Ferrer S, et al. Lead optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series for the treatment of Malaria. Journal of Medicinal Chemistry. PMID 32248693 DOI: 10.1021/Acs.Jmedchem.0C00311 |
0.786 |
|
| 2018 |
Kokkonda S, El Mazouni F, White KL, White J, Shackleford DM, Lafuente-Monasterio MJ, Rowland P, Manjalanagara K, Joseph JT, Garcia-Pérez A, Fernandez J, Gamo FJ, Waterson D, Burrows JN, Palmer MJ, et al. Isoxazolopyrimidine-Based Inhibitors of Dihydroorotate Dehydrogenase with Antimalarial Activity. Acs Omega. 3: 9227-9240. PMID 30197997 DOI: 10.1021/acsomega.8b01573 |
0.762 |
|
| 2016 |
Phillips MA, White KL, Kokkonda S, Deng X, White J, El Mazouni F, Marsh KC, Tomchick DR, Manjalanagara K, Rudra KR, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Shackleford DM, et al. A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria. Acs Infectious Diseases. PMID 27641613 DOI: 10.1021/Acsinfecdis.6B00144 |
0.77 |
|
| 2016 |
Kokkonda S, Deng X, White KL, Coterón JM, Marco M, de Las Heras L, White J, El Mazouni F, Tomchick DR, Manjalanagara K, Rudra KR, Chen G, Morizzi J, Ryan E, Kaminsky W, et al. Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidines targeting Plasmodium falciparum dihydroorotate dehydrogenase display potent and selective antimalarial activity. Journal of Medicinal Chemistry. PMID 27127993 DOI: 10.1021/Acs.Jmedchem.6B00275 |
0.781 |
|
| 2015 |
Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, et al. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Science Translational Medicine. 7: 296ra111. PMID 26180101 DOI: 10.1126/Scitranslmed.Aaa6645 |
0.772 |
|
| 2015 |
Mudeppa DG, Kumar S, Kokkonda S, White J, Rathod PK. Topoisomerase II from Human Malaria Parasites: Expression, Purification, and Selective Inhibition. The Journal of Biological Chemistry. PMID 26055707 DOI: 10.1074/Jbc.M115.639039 |
0.726 |
|
| 2014 |
Deng X, Kokkonda S, El Mazouni F, White J, Burrows JN, Kaminsky W, Charman SA, Matthews D, Rathod PK, Phillips MA. Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. Journal of Medicinal Chemistry. 57: 5381-94. PMID 24801997 DOI: 10.1021/Jm500481T |
0.698 |
|
| 2012 |
Marwaha A, White J, El Mazouni F, Creason SA, Kokkonda S, Buckner FS, Charman SA, Phillips MA, Rathod PK. Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase. Journal of Medicinal Chemistry. 55: 7425-36. PMID 22877245 DOI: 10.1021/Jm300351W |
0.773 |
|
| 2011 |
Coteron JM, Marco M, Esquivias J, Deng X, White KL, White J, Koltun M, El Mazouni F, Kokkonda S, Katneni K, Bhamidipati R, Shackleford DM, Angulo-Barturen I, Ferrer SB, Jiménez-Díaz MB, et al. Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. Journal of Medicinal Chemistry. 54: 5540-61. PMID 21696174 DOI: 10.1021/Jm200592F |
0.776 |
|
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