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Eddy Arnold - Publications

Affiliations: 
CABM and Rutgers University 
Area:
structural biology, polymerases, reverse transcriptase, HIV, drug design
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10 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Xavier Ruiz F, Arnold E. Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance. Current Opinion in Structural Biology. 61: 113-123. PMID 31935541 DOI: 10.1016/J.Sbi.2019.11.011  0.308
2019 Ruiz FX, Hoang A, Das K, Arnold E. Structural Basis of HIV-1 Inhibition by the Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1. Journal of Medicinal Chemistry. PMID 31603676 DOI: 10.1021/Acs.Jmedchem.9B01289  0.317
2019 Arnold E, Wu H, Johnson JE. Michael G. Rossmann (1930-2019), pioneer in macromolecular and virus crystallography: scientist, mentor and friend. Acta Crystallographica. Section D, Structural Biology. 75: 523-527. PMID 31205014 DOI: 10.1107/S2059798319008398  0.378
2019 Arnold E, Hasan SS, Johnson JE, Wu H, Zhao R. Michael G. Rossmann (1930–2019): pioneer in crystallography of macromolecules and viruses Acta Crystallographica Section a Foundations and Advances. 75: a450-a451. DOI: 10.1107/S0108767319095618  0.342
2012 Johnson BC, Pauly GT, Rai G, Patel D, Bauman JD, Baker HL, Das K, Schneider JP, Maloney DJ, Arnold E, Thomas CJ, Hughes SH. A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants. Retrovirology. 9: 99. PMID 23217210 DOI: 10.1186/1742-4690-9-99  0.309
2011 Das K, Bauman JD, Rim AS, Dharia C, Clark AD, Camarasa MJ, Balzarini J, Arnold E. Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. Journal of Medicinal Chemistry. 54: 2727-37. PMID 21446702 DOI: 10.1021/Jm101536X  0.307
2008 Das K, Bauman JD, Clark AD, Frenkel YV, Lewi PJ, Shatkin AJ, Hughes SH, Arnold E. High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Proceedings of the National Academy of Sciences of the United States of America. 105: 1466-71. PMID 18230722 DOI: 10.1073/Pnas.0711209105  0.324
2006 Himmel DM, Sarafianos SG, Dharmasena S, Hossain MM, McCoy-Simandle K, Ilina T, Clark AD, Knight JL, Julias JG, Clark PK, Krogh-Jespersen K, Levy RM, Hughes SH, Parniak MA, Arnold E. HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Acs Chemical Biology. 1: 702-12. PMID 17184135 DOI: 10.1021/Cb600303Y  0.327
2006 Hamburgh ME, Curr KA, Monaghan M, Rao VR, Tripathi S, Preston BD, Sarafianos S, Arnold E, Darden T, Prasad VR. Structural determinants of slippage-mediated mutations by human immunodeficiency virus type 1 reverse transcriptase. The Journal of Biological Chemistry. 281: 7421-8. PMID 16423828 DOI: 10.1074/Jbc.M511380200  0.301
2004 Tuske S, Sarafianos SG, Clark AD, Ding J, Naeger LK, White KL, Miller MD, Gibbs CS, Boyer PL, Clark P, Wang G, Gaffney BL, Jones RA, Jerina DM, Hughes SH, ... Arnold E, et al. Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Nature Structural & Molecular Biology. 11: 469-74. PMID 15107837 DOI: 10.1038/Nsmb760  0.311
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