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Yigong Shi - Publications

Affiliations: 
Life Sciences Tsinghua National University, Beijing, Beijing Shi, China 
Area:
structural and molecular mechanisms involved in tumorigenesis
Website:
http://ygshi.life.tsinghua.edu.cn/people.html

224 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Tian L, Li Y, Shi Y. Dark and Dronc activation in . Proceedings of the National Academy of Sciences of the United States of America. 121: e2312784121. PMID 38381783 DOI: 10.1073/pnas.2312784121  0.323
2020 Thomas C, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Duong Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, ... ... Shi Y, et al. Structural and functional diversity calls for a new classification of ABC transporters. Febs Letters. PMID 32978974 DOI: 10.1002/1873-3468.13935  0.637
2020 Huang G, Zhang Y, Zhu X, Zeng C, Wang Q, Zhou Q, Tao Q, Liu M, Lei J, Yan C, Shi Y. Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis. Cell Research. PMID 32376910 DOI: 10.1038/S41422-020-0319-4  0.318
2020 Zhang Y, Li S, Zeng C, Huang G, Zhu X, Wang Q, Wang K, Zhou Q, Yan C, Zhang W, Yang G, Liu M, Tao Q, Lei J, Shi Y. Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex. Cell Research. PMID 32367042 DOI: 10.1038/S41422-020-0320-Y  0.365
2019 Wan R, Bai R, Shi Y. Molecular choreography of pre-mRNA splicing by the spliceosome. Current Opinion in Structural Biology. 59: 124-133. PMID 31476650 DOI: 10.1016/J.Sbi.2019.07.010  0.338
2019 Wan R, Bai R, Yan C, Lei J, Shi Y. Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell. PMID 30879786 DOI: 10.1016/j.cell.2019.02.006  0.359
2019 Zhang X, Zhan X, Yan C, Zhang W, Liu D, Lei J, Shi Y. Structures of the human spliceosomes before and after release of the ligated exon. Cell Research. PMID 30728453 DOI: 10.1038/s41422-019-0143-x  0.321
2019 Yan C, Wan R, Shi Y. Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome. Cold Spring Harbor Perspectives in Biology. 11. PMID 30602541 DOI: 10.1101/Cshperspect.A032409  0.31
2019 Zhou R, Yang G, Guo X, Zhou Q, Lei J, Shi Y. Recognition of the amyloid precursor protein by human gamma-secretase. Science. 363. DOI: 10.2210/Pdb6Iyc/Pdb  0.321
2019 Bai R, Wan R, Yan C, Lei J, Shi Y. Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation Science. 360: 1423-1429. DOI: 10.2210/Pdb5Zwo/Pdb  0.357
2018 Wu S, Song W, Wong CCL, Shi Y. Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein. Proceedings of the National Academy of Sciences of the United States of America. PMID 30559186 DOI: 10.1073/Pnas.1810870116  0.356
2018 Su Q, Hu F, Ge X, Lei J, Yu S, Wang T, Zhou Q, Mei C, Shi Y. Structure of the human PKD1/PKD2 complex. Science (New York, N.Y.). PMID 30093605 DOI: 10.2210/Pdb6A70/Pdb  0.353
2018 Yang SF, Sun AA, Shi Y, Li F, Pickett HA. Structural and functional characterization of the RBBP4-ZNF827 interaction and its role in NuRD recruitment to telomeres. The Biochemical Journal. PMID 30045876 DOI: 10.1042/Bcj20180310  0.326
2018 Bai R, Wan R, Yan C, Lei J, Shi Y. Structures of the fully assembled spliceosome before activation. Science (New York, N.Y.). PMID 29794219 DOI: 10.1126/Science.Aau0325  0.309
2018 Zhang X, Wang Q, Wu J, Wang J, Shi Y, Liu M. Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581294 DOI: 10.1073/Pnas.1720859115  0.396
2018 Zhang X, Yan C, Zhan X, Li L, Lei J, Shi Y. Structure of the human activated spliceosome in three conformational states. Cell Research. PMID 29360106 DOI: 10.1038/cr.2018.14  0.331
2018 Zhan X, Yan C, Zhang X, Lei J, Shi Y. Structure of a human catalytic step I spliceosome. Science (New York, N.Y.). PMID 29301961 DOI: 10.1126/Science.Aar6401  0.337
2018 Yang G, Zhou R, Zhou Q, Guo X, Yan C, Ke M, Lei J, Shi Y. Structural basis of Notch recognition by human gamma-secretase Nature. 565: 192-197. DOI: 10.2210/Pdb6Idf/Pdb  0.375
2017 Bai R, Yan C, Wan R, Lei J, Shi Y. Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae. Cell. PMID 29153833 DOI: 10.1016/J.Cell.2017.10.038  0.332
2017 Zhou R, Yang G, Shi Y. Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078389 DOI: 10.1073/Pnas.1713605114  0.315
2017 Shi Y. Mechanistic insights into precursor messenger RNA splicing by the spliceosome. Nature Reviews. Molecular Cell Biology. PMID 28951565 DOI: 10.1038/Nrm.2017.86  0.321
2017 Wan R, Yan C, Bai R, Lei J, Shi Y. Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae. Cell. PMID 28919079 DOI: 10.1016/J.Cell.2017.08.029  0.375
2017 Shi Y. The Spliceosome: A Protein-directed Metalloribozyme. Journal of Molecular Biology. PMID 28733144 DOI: 10.1016/J.Jmb.2017.07.010  0.331
2017 Yang G, Zhou R, Shi Y. Cryo-EM structures of human γ-secretase. Current Opinion in Structural Biology. 46: 55-64. PMID 28628788 DOI: 10.1016/J.Sbi.2017.05.013  0.319
2017 Zhang X, Yan C, Hang J, Finci LI, Lei J, Shi Y. An Atomic Structure of the Human Spliceosome. Cell. PMID 28502770 DOI: 10.1016/J.Cell.2017.04.033  0.804
2017 Li Y, Zhou M, Hu Q, Bai XC, Huang W, Scheres SH, Shi Y. Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme. Proceedings of the National Academy of Sciences of the United States of America. PMID 28143931 DOI: 10.1073/Pnas.1620626114  0.778
2017 Zhou R, Shi Y, Yang G. Expression, Purification, and Enzymatic Characterization of Intramembrane Proteases. Methods in Enzymology. 584: 127-155. PMID 28065261 DOI: 10.1016/Bs.Mie.2016.09.046  0.35
2016 Yan C, Wan R, Bai R, Huang G, Shi Y. Structure of a yeast step II catalytically activated spliceosome. Science (New York, N.Y.). PMID 27980089 DOI: 10.1126/Science.Aak9979  0.36
2016 Wan R, Yan C, Bai R, Huang G, Shi Y. Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution. Science (New York, N.Y.). PMID 27445308 DOI: 10.1126/Science.Aag2235  0.347
2016 Yan C, Wan R, Bai R, Huang G, Shi Y. Structure of a yeast catalytically activated spliceosome at 3.5 Å resolution. Science (New York, N.Y.). PMID 27445306 DOI: 10.1126/Science.Aag0291  0.353
2016 Huang X, Luan B, Wu J, Shi Y. An atomic structure of the human 26S proteasome. Nature Structural & Molecular Biology. PMID 27428775 DOI: 10.1038/Nsmb.3273  0.63
2016 Bao H, Li F, Wang C, Wang N, Jiang Y, Tang Y, Wu J, Shi Y. Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3. The Journal of Biological Chemistry. PMID 27311713 DOI: 10.1074/Jbc.M116.736140  0.318
2016 Xue S, Wang J, Zhang X, Shi Y, Li B, Bao Q, Pang W, Ai D, Zhu Y, He J. Endothelial ATP-binding cassette G1 in mouse endothelium protects against hemodynamic-induced atherosclerosis. Biochemical and Biophysical Research Communications. PMID 27297110 DOI: 10.1016/j.bbrc.2016.06.050  0.46
2016 Gong X, Qian H, Zhou X, Wu J, Wan T, Cao P, Huang W, Zhao X, Wang X, Wang P, Shi Y, Gao GF, Zhou Q, Yan N. Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell. PMID 27238017 DOI: 10.1016/J.Cell.2016.05.022  0.607
2016 Luan B, Huang X, Wu J, Mei Z, Wang Y, Xue X, Yan C, Wang J, Finley DJ, Shi Y, Wang F. Structure of an endogenous yeast 26S proteasome reveals two major conformational states. Proceedings of the National Academy of Sciences of the United States of America. PMID 26929360 DOI: 10.1073/Pnas.1601561113  0.638
2016 Zhang Z, Hu F, Liu Y, Ma B, Chen X, Zhu K, Shi Y, Wei T, Xing Y, Gao Y, Lu H, Liu Y, Kang Q. Activation of type 5 metabotropic glutamate receptor promotes the proliferation of rat retinal progenitor cell via activation of the PI-3-K and MAPK signaling pathways. Neuroscience. PMID 26902516 DOI: 10.1016/J.Neuroscience.2016.02.030  0.426
2016 Zheng W, Men H, Li J, Xing Y, Wu B, Wang Z, Li J, Teng D, Shi Y, Li J, Jiang P, Cai J. Global MicroRNA Expression Profiling of Mouse Livers following Ischemia-Reperfusion Injury at Different Stages. Plos One. 11: e0148677. PMID 26859886 DOI: 10.1371/journal.pone.0148677  0.347
2016 Jiang T, Liu M, Wu J, Shi Y. Structural and biochemical analysis of Bcl-2 interaction with the hepatitis B virus protein HBx. Proceedings of the National Academy of Sciences of the United States of America. PMID 26858413 DOI: 10.1073/Pnas.1525616113  0.423
2016 Sun L, Li X, Shi Y. Structural biology of intramembrane proteases: mechanistic insights from rhomboid and S2P to γ-secretase. Current Opinion in Structural Biology. 37: 97-107. PMID 26811996 DOI: 10.1016/J.Sbi.2015.12.008  0.551
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... Shi Y, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.531
2016 Wan R, Yan C, Bai R, Wang L, Huang M, Wong CC, Shi Y. The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis. Science (New York, N.Y.). PMID 26743623 DOI: 10.1126/Science.Aad6466  0.305
2016 Yan X, Shi Y, Kou B, Zhu Z, Chai J, Chen D, Guo H. [Keratin 18 phosphorylation increases autophagy of colorectal cancer HCT116 cells and enhanced its sensitivity to oxaliplatin]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology. 32: 34-8. PMID 26728375  0.428
2016 Yan C, Wan R, Bai R, Huang G, Shi Y. Structure of a yeast activated spliceosome at 3.5 angstrom resolution Science. 353: 904-911. DOI: 10.2210/Pdb5Gm6/Pdb  0.364
2015 Bai XC, Rajendra E, Yang G, Shi Y, Scheres SH. Sampling the conformational space of the catalytic subunit of human γ-secretase. Elife. 4. PMID 26623517 DOI: 10.7554/Elife.11182  0.392
2015 Zhou M, Li Y, Hu Q, Bai XC, Huang W, Yan C, Scheres SH, Shi Y. Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1. Genes & Development. PMID 26543158 DOI: 10.1101/Gad.272278.115  0.77
2015 Yan C, Hang J, Wan R, Huang M, Wong CC, Shi Y. Structure of a yeast spliceosome at 3.6-angstrom resolution. Science (New York, N.Y.). 349: 1182-91. PMID 26292707 DOI: 10.1126/Science.Aac7629  0.323
2015 Hang J, Wan R, Yan C, Shi Y. Structural basis of pre-mRNA splicing. Science (New York, N.Y.). 349: 1191-8. PMID 26292705 DOI: 10.1126/Science.Aac8159  0.306
2015 Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SH, Shi Y. An atomic structure of human γ-secretase. Nature. 525: 212-7. PMID 26280335 DOI: 10.1038/Nature14892  0.747
2015 Li C, Li Y, Xing Y, Zhang Z, Zhang X, Li Z, Shi Y, Ma T, Ma R, Wang K, Wei J. Perovskite Solar Cell Using a Two-Dimensional Titania Nanosheet Thin Film as the Compact Layer. Acs Applied Materials & Interfaces. 7: 15117-22. PMID 26158908 DOI: 10.1021/acsami.5b01959  0.34
2015 Chai J, Chen P, Feng R, Liang H, Shen X, Tong G, Cheng J, Li K, Xie S, Shi Y, Wang D. Life events and chronic physical conditions among left-behind farmers in rural China a cross-sectional study. Bmc Public Health. 15: 594. PMID 26130045 DOI: 10.1186/s12889-015-1877-0  0.358
2015 Sun L, Zhao L, Yang G, Yan C, Zhou R, Zhou X, Xie T, Zhao Y, Wu S, Li X, Shi Y. Structural basis of human γ-secretase assembly. Proceedings of the National Academy of Sciences of the United States of America. 112: 6003-8. PMID 25918421 DOI: 10.1073/Pnas.1506242112  0.396
2015 Chai J, Shen X, Feng R, Cheng J, Chen Y, Zha Z, Jia S, Liang H, Zhao T, Sha R, Shi Y, Li K, Wang D. eCROPS-CA: a systematic approach toward effective and sustainable cancer prevention in rural China. Bmc Cancer. 15: 233. PMID 25886568 DOI: 10.1186/s12885-015-1253-6  0.373
2015 Dang S, Wu S, Wang J, Li H, Huang M, He W, Li YM, Wong CC, Shi Y. Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH. Proceedings of the National Academy of Sciences of the United States of America. 112: 3344-9. PMID 25733893 DOI: 10.1073/Pnas.1502150112  0.318
2015 Pang Y, Bai XC, Yan C, Hao Q, Chen Z, Wang JW, Scheres SH, Shi Y. Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila. Genes & Development. 29: 277-87. PMID 25644603 DOI: 10.1101/Gad.255877.114  0.466
2015 Shen X, Li K, Chen P, Feng R, Liang H, Tong G, Chen J, Chai J, Shi Y, Xie S, Wang D. Associations of blood pressure with common factors among left-behind farmers in rural China: a cross-sectional study using quantile regression analysis. Medicine. 94: e142. PMID 25590833 DOI: 10.1097/MD.0000000000000142  0.363
2015 Yan Z, Bai XC, Yan C, Wu J, Li Z, Xie T, Peng W, Yin CC, Li X, Scheres SH, Shi Y, Yan N. Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature. 517: 50-5. PMID 25517095 DOI: 10.1038/Nature14063  0.638
2015 Liang H, Cheng J, Shen X, Chen P, Tong G, Chai J, Li K, Xie S, Shi Y, Wang D, Sun Y. Relationships between stressful life events and impaired fasting glucose among left-behind farmers in rural China. Journal of Psychosomatic Research. 78: 178-83. PMID 25477301 DOI: 10.1016/j.jpsychores.2014.10.009  0.347
2014 Zhou H, Shi Y, Dong Q, Zhang H, Xing Y, Wang K, Du Y, Ma T. Hole-Conductor-Free, Metal-Electrode-Free TiO2/CH3NH3PbI3 Heterojunction Solar Cells Based on a Low-Temperature Carbon Electrode. The Journal of Physical Chemistry Letters. 5: 3241-6. PMID 26276339 DOI: 10.1021/jz5017069  0.355
2014 Shen XR, Chai J, Feng R, Liu TZ, Tong GX, Cheng J, Li KC, Xie SY, Shi Y, Wang DB. Refining and validating a two-stage and web-based cancer risk assessment tool for village doctors in China. Asian Pacific Journal of Cancer Prevention : Apjcp. 15: 10683-90. PMID 25605159 DOI: 10.7314/APJCP.2014.15.24.10683  0.383
2014 Hu Q, Wu D, Chen W, Yan Z, Yan C, He T, Liang Q, Shi Y. Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome. Proceedings of the National Academy of Sciences of the United States of America. 111: 16254-61. PMID 25313070 DOI: 10.1073/Pnas.1418000111  0.419
2014 Guo R, Zheng L, Park JW, Lv R, Chen H, Jiao F, Xu W, Mu S, Wen H, Qiu J, Wang Z, Yang P, Wu F, Hui J, Fu X, ... Shi YG, ... Shi Y, et al. BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing. Molecular Cell. 56: 298-310. PMID 25263594 DOI: 10.1016/J.Molcel.2014.08.022  0.431
2014 Wang K, Shi Y, Zhang H, Xing Y, Dong Q, Ma T. Selenium as a photoabsorber for inorganic-organic hybrid solar cells. Physical Chemistry Chemical Physics : Pccp. 16: 23316-9. PMID 25259378 DOI: 10.1039/c4cp02821j  0.368
2014 Xie T, Yan C, Zhou R, Zhao Y, Sun L, Yang G, Lu P, Ma D, Shi Y. Crystal structure of the γ-secretase component nicastrin. Proceedings of the National Academy of Sciences of the United States of America. 111: 13349-54. PMID 25197054 DOI: 10.1073/Pnas.1414837111  0.748
2014 Lu P, Bai XC, Ma D, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R, Scheres SH, Shi Y. Three-dimensional structure of human γ-secretase. Nature. 512: 166-70. PMID 25043039 DOI: 10.1038/Nature13567  0.751
2014 Zhang H, Shi Y, Yan F, Wang L, Wang K, Xing Y, Dong Q, Ma T. A dual functional additive for the HTM layer in perovskite solar cells. Chemical Communications (Cambridge, England). 50: 5020-2. PMID 24709962 DOI: 10.1039/C3Cc49458F  0.358
2014 Condon SM, Mitsuuchi Y, Deng Y, LaPorte MG, Rippin SR, Haimowitz T, Alexander MD, Kumar PT, Hendi MS, Lee YH, Benetatos CA, Yu G, Kapoor GS, Neiman E, Seipel ME, ... ... Shi Y, et al. Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies. Journal of Medicinal Chemistry. 57: 3666-77. PMID 24684347 DOI: 10.1021/Jm500176W  0.518
2014 Lackford B, Yao C, Charles GM, Weng L, Zheng X, Choi EA, Xie X, Wan J, Xing Y, Freudenberg JM, Yang P, Jothi R, Hu G, Shi Y. Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal. The Embo Journal. 33: 878-89. PMID 24596251 DOI: 10.1002/Embj.201386537  0.398
2014 Benetatos CA, Mitsuuchi Y, Burns JM, Neiman EM, Condon SM, Yu G, Seipel ME, Kapoor GS, Laporte MG, Rippin SR, Deng Y, Hendi MS, Tirunahari PK, Lee YH, Haimowitz T, ... ... Shi Y, et al. Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models. Molecular Cancer Therapeutics. 13: 867-79. PMID 24563541 DOI: 10.1158/1535-7163.Mct-13-0798  0.396
2014 Zhou L, Zhou Y, Hang J, Wan R, Lu G, Yan C, Shi Y. Crystal structure and biochemical analysis of the heptameric Lsm1-7 complex. Cell Research. 24: 497-500. PMID 24513854 DOI: 10.1038/Cr.2014.18  0.309
2014 Lu P, Ma D, Yan C, Gong X, Du M, Shi Y. Structure and mechanism of a eukaryotic transmembrane ascorbate-dependent oxidoreductase. Proceedings of the National Academy of Sciences of the United States of America. 111: 1813-8. PMID 24449903 DOI: 10.1073/Pnas.1323931111  0.736
2014 Zhou L, Hang J, Zhou Y, Wan R, Lu G, Yin P, Yan C, Shi Y. Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA. Nature. 506: 116-20. PMID 24240276 DOI: 10.1038/Nature12803  0.493
2014 Chai J, Shi Y. Apoptosome and inflammasome: Conserved machineries for caspase activation National Science Review. 1: 101-118. DOI: 10.1093/Nsr/Nwt025  0.626
2014 Shi Y. Life, career, and structural biology Physica Scripta. 89. DOI: 10.1088/0031-8949/89/6/068004  0.319
2013 Yin P, Li Q, Yan C, Liu Y, Liu J, Yu F, Wang Z, Long J, He J, Wang HW, Wang J, Zhu JK, Shi Y, Yan N. Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature. 504: 168-71. PMID 24162847 DOI: 10.1038/Nature12651  0.671
2013 Yao C, Choi EA, Weng L, Xie X, Wan J, Xing Y, Moresco JJ, Tu PG, Yates JR, Shi Y. Overlapping and distinct functions of CstF64 and CstF64Ï„ in mammalian mRNA 3' processing. Rna (New York, N.Y.). 19: 1781-90. PMID 24149845 DOI: 10.1261/Rna.042317.113  0.405
2013 Xie T, Peng W, Yan C, Wu J, Gong X, Shi Y. Structural insights into RIP3-mediated necroptotic signaling. Cell Reports. 5: 70-8. PMID 24095729 DOI: 10.1016/J.Celrep.2013.08.044  0.364
2013 Huang W, Jiang T, Choi W, Qi S, Pang Y, Hu Q, Xu Y, Gong X, Jeffrey PD, Wang J, Shi Y. Mechanistic insights into CED-4-mediated activation of CED-3. Genes & Development. 27: 2039-48. PMID 24065769 DOI: 10.1101/Gad.224428.113  0.82
2013 Shi Y. Common folds and transport mechanisms of secondary active transporters. Annual Review of Biophysics. 42: 51-72. PMID 23654302 DOI: 10.1146/Annurev-Biophys-083012-130429  0.32
2013 Liu J, Mei Z, Li N, Qi Y, Xu Y, Shi Y, Wang F, Lei J, Gao N. Structural dynamics of the MecA-ClpC complex: a type II AAA+ protein unfolding machine. The Journal of Biological Chemistry. 288: 17597-608. PMID 23595989 DOI: 10.1074/Jbc.M113.458752  0.377
2013 Ma D, Lu P, Shi Y. Substrate selectivity of the acid-activated glutamate/γ-aminobutyric acid (GABA) antiporter GadC from Escherichia coli. The Journal of Biological Chemistry. 288: 15148-53. PMID 23589309 DOI: 10.1074/Jbc.M113.474502  0.686
2013 Yan H, Huang W, Yan C, Gong X, Jiang S, Zhao Y, Wang J, Shi Y. Structure and mechanism of a nitrate transporter. Cell Reports. 3: 716-23. PMID 23523348 DOI: 10.1016/J.Celrep.2013.03.007  0.351
2013 Xie T, Peng W, Liu Y, Yan C, Maki J, Degterev A, Yuan J, Shi Y. Structural basis of RIP1 inhibition by necrostatins. Structure (London, England : 1993). 21: 493-9. PMID 23473668 DOI: 10.1016/J.Str.2013.01.016  0.426
2013 Lu P, Ma D, Chen Y, Guo Y, Chen GQ, Deng H, Shi Y. L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia. Cell Research. 23: 635-44. PMID 23337585 DOI: 10.1038/Cr.2013.13  0.691
2013 Li X, Dang S, Yan C, Gong X, Wang J, Shi Y. Structure of a presenilin family intramembrane aspartate protease. Nature. 493: 56-61. PMID 23254940 DOI: 10.1038/Nature11801  0.523
2012 Yao C, Biesinger J, Wan J, Weng L, Xing Y, Xie X, Shi Y. Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylation. Proceedings of the National Academy of Sciences of the United States of America. 109: 18773-8. PMID 23112178 DOI: 10.1073/Pnas.1211101109  0.431
2012 Yin P, Deng D, Yan C, Pan X, Xi JJ, Yan N, Shi Y. Specific DNA-RNA hybrid recognition by TAL effectors. Cell Reports. 2: 707-13. PMID 23022487 DOI: 10.1016/J.Celrep.2012.09.001  0.779
2012 Deng D, Yin P, Yan C, Pan X, Gong X, Qi S, Xie T, Mahfouz M, Zhu JK, Yan N, Shi Y. Recognition of methylated DNA by TAL effectors. Cell Research. 22: 1502-4. PMID 22945353 DOI: 10.1038/Cr.2012.127  0.748
2012 Wong AH, Yan C, Shi Y. Crystal structure of the yeast metacaspase Yca1. The Journal of Biological Chemistry. 287: 29251-9. PMID 22761449 DOI: 10.1074/Jbc.M112.381806  0.443
2012 Ma D, Lu P, Yan C, Fan C, Yin P, Wang J, Shi Y. Structure and mechanism of a glutamate-GABA antiporter. Nature. 483: 632-6. PMID 22407317 DOI: 10.1038/Nature10917  0.747
2012 Wu D, Hu Q, Yan Z, Chen W, Yan C, Huang X, Zhang J, Yang P, Deng H, Wang J, Deng X, Shi Y. Structural basis of ultraviolet-B perception by UVR8. Nature. 484: 214-9. PMID 22388820 DOI: 10.1038/Nature10931  0.318
2012 Huang W, Choi W, Hu W, Mi N, Guo Q, Ma M, Liu M, Tian Y, Lu P, Wang FL, Deng H, Liu L, Gao N, Yu L, Shi Y. Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Research. 22: 473-89. PMID 22310240 DOI: 10.1038/Cr.2012.24  0.745
2012 Deng D, Yan C, Pan X, Mahfouz M, Wang J, Zhu JK, Shi Y, Yan N. Structural basis for sequence-specific recognition of DNA by TAL effectors. Science (New York, N.Y.). 335: 720-3. PMID 22223738 DOI: 10.1126/Science.1215670  0.793
2011 Yu JW, Jeffrey PD, Ha JY, Yang X, Shi Y. Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region. Proceedings of the National Academy of Sciences of the United States of America. 108: 21004-9. PMID 22158899 DOI: 10.1073/Pnas.1111708108  0.437
2011 Li X, Wang J, Shi Y. Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE. Nature Communications. 2: 408. PMID 21811237 DOI: 10.1038/Ncomms1418  0.604
2011 Shi Y, Yang S, Troup S, Lu X, Callaghan S, Park DS, Xing Y, Yang X. Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1. Oncology Reports. 25: 1713-9. PMID 21479363 DOI: 10.3892/or.2011.1248  0.456
2011 Wang F, Mei Z, Qi Y, Yan C, Hu Q, Wang J, Shi Y. Structure and mechanism of the hexameric MecA-ClpC molecular machine. Nature. 471: 331-5. PMID 21368759 DOI: 10.1038/Nature09780  0.409
2010 Zhang P, Wang J, Shi Y. Structure and mechanism of the S component of a bacterial ECF transporter. Nature. 468: 717-20. PMID 20972419 DOI: 10.1038/Nature09488  0.338
2010 Qi S, Pang Y, Hu Q, Liu Q, Li H, Zhou Y, He T, Liang Q, Liu Y, Yuan X, Luo G, Li H, Wang J, Yan N, Shi Y. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell. 141: 446-57. PMID 20434985 DOI: 10.1016/J.Cell.2010.03.017  0.798
2010 Mei Y, Yong J, Liu H, Shi Y, Meinkoth J, Dreyfuss G, Yang X. tRNA binds to cytochrome c and inhibits caspase activation. Molecular Cell. 37: 668-78. PMID 20227371 DOI: 10.1016/J.Molcel.2010.01.023  0.406
2010 Gao X, Zhou L, Jiao X, Lu F, Yan C, Zeng X, Wang J, Shi Y. Mechanism of substrate recognition and transport by an amino acid antiporter. Nature. 463: 828-32. PMID 20090677 DOI: 10.1038/Nature08741  0.368
2009 Wang Y, Huang Y, Wang J, Cheng C, Huang W, Lu P, Xu YN, Wang P, Yan N, Shi Y. Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel. Nature. 462: 467-72. PMID 19940917 DOI: 10.1038/Nature08610  0.782
2009 Huhn J, Jeffrey PD, Larsen K, Rundberget T, Rise F, Cox NR, Arcus V, Shi Y, Miles CO. A structural basis for the reduced toxicity of dinophysistoxin-2. Chemical Research in Toxicology. 22: 1782-6. PMID 19916524 DOI: 10.1021/Tx9001622  0.694
2009 Shi Y. Serine/threonine phosphatases: mechanism through structure. Cell. 139: 468-84. PMID 19879837 DOI: 10.1016/J.Cell.2009.10.006  0.37
2009 Wang F, Mei Z, Qi Y, Yan C, Xiang S, Zhou Z, Hu Q, Wang J, Shi Y. Crystal structure of the MecA degradation tag. The Journal of Biological Chemistry. 284: 34376-81. PMID 19801546 DOI: 10.1074/Jbc.M109.053033  0.437
2009 Mei Z, Wang F, Qi Y, Zhou Z, Hu Q, Li H, Wu J, Shi Y. Molecular determinants of MecA as a degradation tag for the ClpCP protease. The Journal of Biological Chemistry. 284: 34366-75. PMID 19767395 DOI: 10.1074/Jbc.M109.053017  0.576
2009 Gell DA, Feng L, Zhou S, Jeffrey PD, Bendak K, Gow A, Weiss MJ, Shi Y, Mackay JP. A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin. The Journal of Biological Chemistry. 284: 29462-9. PMID 19706593 DOI: 10.1074/Jbc.M109.027045  0.343
2009 Li X, Wang B, Feng L, Kang H, Qi Y, Wang J, Shi Y. Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage. Proceedings of the National Academy of Sciences of the United States of America. 106: 14837-42. PMID 19706448 DOI: 10.1073/Pnas.0903289106  0.544
2009 Geng X, Zhou QH, Kage-Nakadai E, Shi Y, Yan N, Mitani S, Xue D. Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells. Cell Death and Differentiation. 16: 1385-94. PMID 19575016 DOI: 10.1038/Cdd.2009.88  0.668
2009 Zhang F, Wu Z, Zhang P, Tian G, Finley D, Shi Y. Mechanism of substrate unfolding and translocation by the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Molecular Cell. 34: 485-96. PMID 19481528 DOI: 10.1016/J.Molcel.2009.04.022  0.382
2009 Zhang F, Hu M, Tian G, Zhang P, Finley D, Jeffrey PD, Shi Y. Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Molecular Cell. 34: 473-84. PMID 19481527 DOI: 10.1016/J.Molcel.2009.04.021  0.402
2009 Gao X, Lu F, Zhou L, Dang S, Sun L, Li X, Wang J, Shi Y. Structure and mechanism of an amino acid antiporter. Science (New York, N.Y.). 324: 1565-8. PMID 19478139 DOI: 10.1126/Science.1173654  0.451
2009 Yu JW, Jeffrey PD, Shi Y. Mechanism of procaspase-8 activation by c-FLIPL. Proceedings of the National Academy of Sciences of the United States of America. 106: 8169-74. PMID 19416807 DOI: 10.1073/Pnas.0812453106  0.381
2009 Roelofs J, Park S, Haas W, Tian G, McAllister FE, Huo Y, Lee BH, Zhang F, Shi Y, Gygi SP, Finley D. Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature. 459: 861-5. PMID 19412159 DOI: 10.1038/Nature08063  0.358
2009 Shi Y. Assembly and structure of protein phosphatase 2A. Science in China. Series C, Life Sciences / Chinese Academy of Sciences. 52: 135-46. PMID 19277525 DOI: 10.1007/S11427-009-0018-3  0.349
2009 Zhang X, Wang J, Fan C, Li H, Sun H, Gong S, Chen YH, Shi Y. Crystal structure of TIPE2 provides insights into immune homeostasis. Nature Structural & Molecular Biology. 16: 89-90. PMID 19079267 DOI: 10.1038/Nsmb.1522  0.403
2009 Shi Y. Structure and mechanism of Site-2 Protease Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.1949  0.328
2008 Yu JW, Shi Y. FLIP and the death effector domain family Oncogene. 27: 6216-6227. PMID 18931689 DOI: 10.1038/Onc.2008.299  0.412
2008 Xu Y, Chen Y, Zhang P, Jeffrey PD, Shi Y. Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. Molecular Cell. 31: 873-85. PMID 18922469 DOI: 10.1016/J.Molcel.2008.08.006  0.681
2008 Geng X, Shi Y, Nakagawa A, Yoshina S, Mitani S, Shi Y, Xue D. Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3. Nature Structural & Molecular Biology. 15: 1094-101. PMID 18776901 DOI: 10.1038/Nsmb.1488  0.419
2008 Shi Y. Apoptosome assembly. Methods in Enzymology. 442: 141-56. PMID 18662568 DOI: 10.1016/S0076-6879(08)01407-9  0.305
2008 Urban S, Shi Y. Core principles of intramembrane proteolysis: comparison of rhomboid and site-2 family proteases. Current Opinion in Structural Biology. 18: 432-41. PMID 18440799 DOI: 10.1016/J.Sbi.2008.03.005  0.333
2008 Du YF, Shi Y, Xing YF, Xing YF, Zeng FQ, Zeng FQ. Establishment of CXCR4-small interfering RNA retrovirus vector driven by human prostate-specific antigen promoter and its biological effects on prostate cancer in vitro and in vivo. Journal of Cancer Research and Clinical Oncology. 134: 1255-64. PMID 18431597 DOI: 10.1007/s00432-008-0394-2  0.362
2008 Fang C, Tang W, Tang RQ, Wang L, Zhou GQ, Huang K, Li XW, Feng GY, He M, Du LZ, Zhu SM, Xing YL, Sang H, He L, Shi YY. Family-based association studies of CAPON and schizophrenia in the Chinese Han population. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 32: 1210-3. PMID 18430503 DOI: 10.1016/j.pnpbp.2008.03.007  0.362
2008 Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y. Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell. 133: 154-63. PMID 18394995 DOI: 10.1016/J.Cell.2008.02.041  0.61
2008 Shi Y. Deubiquitination of Lys63-linkage by a CYLD UBP. Structure (London, England : 1993). 16: 338-40. PMID 18334208 DOI: 10.1016/J.Str.2008.02.001  0.316
2007 Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, Shi Y. Structure of a site-2 protease family intramembrane metalloprotease. Science (New York, N.Y.). 318: 1608-12. PMID 18063795 DOI: 10.1126/Science.1150755  0.673
2007 Yan N, Shi Y. Allosteric activation of a bacterial stress sensor. Cell. 131: 441-3. PMID 17981109 DOI: 10.1016/J.Cell.2007.10.021  0.627
2007 Chen G, Jeffrey PD, Fuqua C, Shi Y, Chen L. Structural basis for antiactivation in bacterial quorum sensing. Proceedings of the National Academy of Sciences of the United States of America. 104: 16474-9. PMID 17921255 DOI: 10.1073/Pnas.0704843104  0.388
2007 Luo W, Lu Y, Giesy JP, Wang T, Shi Y, Wang G, Xing Y. Effects of land use on concentrations of metals in surface soils and ecological risk around Guanting Reservoir, China. Environmental Geochemistry and Health. 29: 459-71. PMID 17805979 DOI: 10.1007/S10653-007-9115-Z  0.348
2007 Xing Y, Lü YL, Shi YJ, Wang TY, Luo W, Wang G, Ma H, Sun YM. [Assessment on PCBs wastes treatment technologies including incineration, cement kiln and secure landfill]. Huan Jing Ke Xue= Huanjing Kexue / [Bian Ji, Zhongguo Ke Xue Yuan Huan Jing Ke Xue Wei Yuan Hui "Huan Jing Ke Xue" Bian Ji Wei Yuan Hui.]. 28: 673-8. PMID 17633654  0.346
2007 Chen Y, Xu Y, Bao Q, Xing Y, Li Z, Lin Z, Stock JB, Jeffrey PD, Shi Y. Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40. Nature Structural & Molecular Biology. 14: 527-34. PMID 17529992 DOI: 10.1038/Nsmb1254  0.792
2007 Baker RP, Young K, Feng L, Shi Y, Urban S. Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate. Proceedings of the National Academy of Sciences of the United States of America. 104: 8257-62. PMID 17463085 DOI: 10.1073/Pnas.0700814104  0.375
2007 Wang X, Wang J, Gengyo-Ando K, Gu L, Sun CL, Yang C, Shi Y, Kobayashi T, Shi Y, Mitani S, Xie XS, Xue D. C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nature Cell Biology. 9: 541-9. PMID 17401362 DOI: 10.1038/Ncb1574  0.343
2007 Oberstein A, Jeffrey PD, Shi Y. Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. The Journal of Biological Chemistry. 282: 13123-32. PMID 17337444 DOI: 10.1074/Jbc.M700492200  0.743
2007 Wist AD, Gu L, Riedl SJ, Shi Y, McLendon GL. Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP Bioorganic and Medicinal Chemistry. 15: 2935-2943. PMID 17336535 DOI: 10.1016/J.Bmc.2007.02.010  0.368
2007 Bao Q, Lu W, Rabinowitz JD, Shi Y. Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1. Molecular Cell. 25: 181-92. PMID 17244527 DOI: 10.1016/J.Molcel.2006.12.013  0.561
2007 Zhao X, Tang R, Gao B, Shi Y, Zhou J, Guo S, Zhang J, Wang Y, Tang W, Meng J, Li S, Wang H, Ma G, Lin C, Xiao Y, et al. Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia. American Journal of Human Genetics. 80: 12-8. PMID 17160890 DOI: 10.1086/510438  0.377
2007 Luo W, Wang T, Lu Y, Giesy JP, Shi Y, Zheng Y, Xing Y, Wu G. Landscape ecology of the Guanting Reservoir, Beijing, China: multivariate and geostatistical analyses of metals in soils. Environmental Pollution (Barking, Essex : 1987). 146: 567-76. PMID 17010487 DOI: 10.1016/J.Envpol.2006.08.001  0.341
2007 Bao Q, Shi Y. Apoptosome: a platform for the activation of initiator caspases. Cell Death and Differentiation. 14: 56-65. PMID 16977332 DOI: 10.1038/Sj.Cdd.4402028  0.615
2006 Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y. Structure of the protein phosphatase 2A holoenzyme. Cell. 127: 1239-51. PMID 17174897 DOI: 10.1016/J.Cell.2006.11.033  0.721
2006 Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nature Structural & Molecular Biology. 13: 1084-91. PMID 17099694 DOI: 10.1038/Nsmb1179  0.799
2006 Xing Y, Xu Y, Chen Y, Jeffrey PD, Chao Y, Lin Z, Li Z, Strack S, Stock JB, Shi Y. Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell. 127: 341-53. PMID 17055435 DOI: 10.1016/J.Cell.2006.09.025  0.74
2006 Shi Y. Mechanical aspects of apoptosome assembly. Current Opinion in Cell Biology. 18: 677-84. PMID 17046227 DOI: 10.1016/J.Ceb.2006.09.006  0.408
2006 Chao Y, Xing Y, Chen Y, Xu Y, Lin Z, Li Z, Jeffrey PD, Stock JB, Shi Y. Structure and mechanism of the phosphotyrosyl phosphatase activator. Molecular Cell. 23: 535-46. PMID 16916641 DOI: 10.1016/J.Molcel.2006.07.027  0.768
2006 Lin X, Duan X, Liang YY, Su Y, Wrighton KH, Long J, Hu M, Davis CM, Wang J, Brunicardi FC, Shi Y, Chen YG, Meng A, Feng XH. PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell. 125: 915-28. PMID 16751101 DOI: 10.1016/J.Cell.2006.03.044  0.303
2006 Xing Y, Lü YL, Liu WB, Shi YJ, Luo W, Ren HC. [Assessment of PCB pollution in spatial distribution and analysis of the PCB sources in sediments in China]. Huan Jing Ke Xue= Huanjing Kexue / [Bian Ji, Zhongguo Ke Xue Yuan Huan Jing Ke Xue Wei Yuan Hui "Huan Jing Ke Xue" Bian Ji Wei Yuan Hui.]. 27: 228-34. PMID 16686180  0.355
2006 Wang TY, Lu YL, Dawson RW, Shi YJ, Zhang H, Xing Y. Effects of environmental factors on organochlorine pesticide residues in soils of the Guanting Reservoir area, China. Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes. 41: 309-21. PMID 16484090 DOI: 10.1080/03601230500357538  0.354
2006 Yang C, Yan N, Parish J, Wang X, Shi Y, Xue D. RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in Caenorhabditis elegans. The Journal of Biological Chemistry. 281: 9137-44. PMID 16467303 DOI: 10.1074/Jbc.M511742200  0.671
2006 Tang W, Shi Y, Feng G, Yan L, Xing Y, Zhu S, Liu J, Zhao X, Tang R, Du J, Zhang J, He G, Liang P, He L. Family-based association studies of the TCP1 gene and schizophrenia in the Chinese Han population. Journal of Neural Transmission (Vienna, Austria : 1996). 113: 1537-43. PMID 16465465 DOI: 10.1007/s00702-005-0419-9  0.348
2006 Yan N, Huh JR, Schirf V, Demeler B, Hay BA, Shi Y. Structure and activation mechanism of the Drosophila initiator caspase Dronc. The Journal of Biological Chemistry. 281: 8667-74. PMID 16446367 DOI: 10.1074/Jbc.M513232200  0.692
2006 Hu M, Gu L, Li M, Jeffrey PD, Gu W, Shi Y. Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. Plos Biology. 4: e27. PMID 16402859 DOI: 10.1371/Journal.Pbio.0040027  0.358
2006 Tang RQ, Zhao XZ, Shi YY, Tang W, Gu NF, Feng GY, Xing YL, Zhu SM, Sang H, Liang PJ, He L. Family-based association study of Epsin 4 and Schizophrenia. Molecular Psychiatry. 11: 395-9. PMID 16402136 DOI: 10.1038/sj.mp.4001780  0.36
2006 Zhao X, Tang R, Xiao Z, Shi Y, Feng G, Gu N, Shi J, Xing Y, Yan L, Sang H, Zhu S, Liu H, Chen W, Liu J, Tang W, et al. An investigation of the dihydropyrimidinase-like 2 (DPYSL2) gene in schizophrenia: genetic association study and expression analysis. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 9: 705-12. PMID 16321170 DOI: 10.1017/S1461145705006267  0.354
2006 Li FY, Jeffrey PD, Yu JW, Shi Y. Crystal structure of a viral FLIP: insights into FLIP-mediated inhibition of death receptor signaling. The Journal of Biological Chemistry. 281: 2960-8. PMID 16317000 DOI: 10.1074/Jbc.M511074200  0.417
2006 Yan N, Xu Y, Shi Y. 2:1 Stoichiometry of the CED-4-CED-9 complex and the tetrameric CED-4: insights into the regulation of CED-3 activation. Cell Cycle (Georgetown, Tex.). 5: 31-4. PMID 16294007 DOI: 10.4161/Cc.5.1.2263  0.801
2005 Weiss MJ, Zhou S, Feng L, Gell DA, Mackay JP, Shi Y, Gow AJ. Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia. Annals of the New York Academy of Sciences. 1054: 103-17. PMID 16339656 DOI: 10.1196/Annals.1345.013  0.314
2005 Shi YJ, Lu YL, Zhang H, Wang TY, Xing Y. Persistent organic pollutants control strategy in China. Journal of Environmental Sciences (China). 17: 309-14. PMID 16295912  0.352
2005 Yu X, Acehan D, Ménétret JF, Booth CR, Ludtke SJ, Riedl SJ, Shi Y, Wang X, Akey CW. A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. Structure (London, England : 1993). 13: 1725-35. PMID 16271896 DOI: 10.1016/J.Str.2005.09.006  0.425
2005 Yan N, Shi Y. Mechanisms of apoptosis through structural biology. Annual Review of Cell and Developmental Biology. 21: 35-56. PMID 16212486 DOI: 10.1146/Annurev.Cellbio.21.012704.131040  0.684
2005 Hu M, Li P, Song L, Jeffrey PD, Chenova TA, Wilkinson KD, Cohen RE, Shi Y. Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. The Embo Journal. 24: 3747-56. PMID 16211010 DOI: 10.1038/Sj.Emboj.7600832  0.433
2005 Yan N, Chai J, Lee ES, Gu L, Liu Q, He J, Wu JW, Kokel D, Li H, Hao Q, Xue D, Shi Y. Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature. 437: 831-7. PMID 16208361 DOI: 10.1038/Nature04002  0.785
2005 Bao Q, Riedl SJ, Shi Y. Structure of Apaf-1 in the auto-inhibited form: a critical role for ADP. Cell Cycle (Georgetown, Tex.). 4: 1001-3. PMID 15970665 DOI: 10.4161/Cc.4.8.1849  0.65
2005 Xing Y, Lu Y, Dawson RW, Shi Y, Zhang H, Wang T, Liu W, Ren H. A spatial temporal assessment of pollution from PCBs in China. Chemosphere. 60: 731-9. PMID 15964056 DOI: 10.1016/j.chemosphere.2005.05.001  0.354
2005 Chao Y, Shiozaki EN, Srinivasula SM, Rigotti DJ, Fairman R, Shi Y. Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. Plos Biology. 3: e183. PMID 15941357 DOI: 10.1371/Journal.Pbio.0030183  0.809
2005 Feng L, Zhou S, Gu L, Gell DA, Mackay JP, Weiss MJ, Gow AJ, Shi Y. Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem. Nature. 435: 697-701. PMID 15931225 DOI: 10.1038/Nature03609  0.322
2005 Riedl SJ, Li W, Chao Y, Schwarzenbacher R, Shi Y. Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature. 434: 926-33. PMID 15829969 DOI: 10.1038/Nature03465  0.482
2004 Tibbetts MD, Shiozaki EN, Gu L, McDonald ER, El-Deiry WS, Shi Y. Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2. Structure (London, England : 1993). 12: 2257-63. PMID 15576038 DOI: 10.1016/J.Str.2004.10.007  0.807
2004 Feng L, Gell DA, Zhou S, Gu L, Kong Y, Li J, Hu M, Yan N, Lee C, Rich AM, Armstrong RS, Lay PA, Gow AJ, Weiss MJ, Mackay JP, ... Shi Y, et al. Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin. Cell. 119: 629-40. PMID 15550245 DOI: 10.1016/J.Cell.2004.11.025  0.609
2004 Riedl SJ, Shi Y. Molecular mechanisms of caspase regulation during apoptosis. Nature Reviews. Molecular Cell Biology. 5: 897-907. PMID 15520809 DOI: 10.1038/Nrm1496  0.404
2004 Yan N, Gu L, Kokel D, Chai J, Li W, Han A, Chen L, Xue D, Shi Y. Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4. Molecular Cell. 15: 999-1006. PMID 15383288 DOI: 10.1016/J.Molcel.2004.08.022  0.745
2004 Shiozaki EN, Shi Y. Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology. Trends in Biochemical Sciences. 29: 486-94. PMID 15337122 DOI: 10.1016/J.Tibs.2004.07.003  0.811
2004 La P, Silva AC, Hou Z, Wang H, Schnepp RW, Yan N, Shi Y, Hua X. Direct binding of DNA by tumor suppressor menin. The Journal of Biological Chemistry. 279: 49045-54. PMID 15331604 DOI: 10.1074/Jbc.M409358200  0.656
2004 Shi Y. Caspase activation, inhibition, and reactivation: a mechanistic view. Protein Science : a Publication of the Protein Society. 13: 1979-87. PMID 15273300 DOI: 10.1110/Ps.04789804  0.436
2004 Shi Y. Caspase activation: revisiting the induced proximity model. Cell. 117: 855-8. PMID 15210107 DOI: 10.1016/J.Cell.2004.06.007  0.396
2004 Shiozaki EN, Gu L, Yan N, Shi Y. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Molecular Cell. 14: 405-12. PMID 15125843 DOI: 10.1016/S1097-2765(04)00238-2  0.792
2004 Yan N, Wu JW, Chai J, Li W, Shi Y. Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nature Structural & Molecular Biology. 11: 420-8. PMID 15107838 DOI: 10.1038/Nsmb764  0.787
2004 Huh JR, Vernooy SY, Yu H, Yan N, Shi Y, Guo M, Hay BA. Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. Plos Biology. 2: E15. PMID 14737191 DOI: 10.1371/Journal.Pbio.0020015  0.678
2004 Zhao X, Shi Y, Tang J, Tang R, Yu L, Gu N, Feng G, Zhu S, Liu H, Xing Y, Zhao S, Sang H, Guan Y, St Clair D, He L. A case control and family based association study of the neuregulin1 gene and schizophrenia. Journal of Medical Genetics. 41: 31-4. PMID 14729827 DOI: 10.1136/jmg.2003.014977  0.354
2003 Yan N, Shi Y. Histone H1.2 as a trigger for apoptosis. Nature Structural Biology. 10: 983-5. PMID 14634629 DOI: 10.1038/Nsb1203-983  0.628
2003 Chai J, Yan N, Huh JR, Wu JW, Li W, Hay BA, Shi Y. Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. Nature Structural Biology. 10: 892-8. PMID 14517550 DOI: 10.1038/Nsb989  0.789
2003 Glover CJ, Hite K, DeLosh R, Scudiero DA, Fivash MJ, Smith LR, Fisher RJ, Wu JW, Shi Y, Kipp RA, McLendon GL, Sausville EA, Shoemaker RH. A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay. Analytical Biochemistry. 320: 157-69. PMID 12927820 DOI: 10.1016/S0003-2697(03)00389-0  0.361
2003 Tang JX, Zhou J, Fan JB, Li XW, Shi YY, Gu NF, Feng GY, Xing YL, Shi JG, He L. Family-based association study of DTNBP1 in 6p22.3 and schizophrenia. Molecular Psychiatry. 8: 717-8. PMID 12888799 DOI: 10.1038/sj.mp.4001287  0.354
2003 Shi Y, Massagué J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 113: 685-700. PMID 12809600 DOI: 10.1016/S0092-8674(03)00432-X  0.304
2003 Chai J, Wu JW, Yan N, Massagué J, Pavletich NP, Shi Y. Features of a Smad3 MH1-DNA complex: Roles of water and zinc in DNA binding Journal of Biological Chemistry. 278: 20327-20331. PMID 12686552 DOI: 10.1074/Jbc.C300134200  0.798
2003 Shiozaki EN, Chai J, Rigotti DJ, Riedl SJ, Li P, Srinivasula SM, Alnemri ES, Fairman R, Shi Y. Mechanism of XIAP-mediated inhibition of caspase-9. Molecular Cell. 11: 519-27. PMID 12620238 DOI: 10.1016/S1097-2765(03)00054-6  0.819
2002 Hu M, Li P, Li M, Li W, Yao T, Wu JW, Gu W, Cohen RE, Shi Y. Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell. 111: 1041-54. PMID 12507430 DOI: 10.1016/S0092-8674(02)01199-6  0.596
2002 Wang X, Yang C, Chai J, Shi Y, Xue D. Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science (New York, N.Y.). 298: 1587-92. PMID 12446902 DOI: 10.1126/Science.1076194  0.568
2002 Wu JW, Krawitz AR, Chai J, Li W, Zhang F, Luo K, Shi Y. Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling. Cell. 111: 357-67. PMID 12419246 DOI: 10.1016/S0092-8674(02)01006-1  0.562
2002 Kipp RA, Case MA, Wist AD, Cresson CM, Carrell M, Griner E, Wiita A, Albiniak PA, Chai J, Shi Y, Semmelhack MF, McLendon GL. Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners Biochemistry. 41: 7344-7349. PMID 12044166 DOI: 10.1021/Bi0121454  0.541
2002 Shi Y. Apoptosome: the cellular engine for the activation of caspase-9. Structure (London, England : 1993). 10: 285-8. PMID 12005427 DOI: 10.1016/S0969-2126(02)00732-3  0.413
2002 Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y. Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. Nature Structural Biology. 9: 436-41. PMID 11967569 DOI: 10.1038/Nsb795  0.71
2002 Shi Y. Mechanisms of caspase activation and inhibition during apoptosis. Molecular Cell. 9: 459-70. PMID 11931755 DOI: 10.1016/S1097-2765(02)00482-3  0.402
2002 Shiozaki EN, Chai J, Shi Y. Oligomerization and activation of caspase-9, induced by Apaf-1 CARD. Proceedings of the National Academy of Sciences of the United States of America. 99: 4197-202. PMID 11904389 DOI: 10.1073/Pnas.072544399  0.81
2002 Shi Y. A conserved tetrapeptide motif: potentiating apoptosis through IAP-binding. Cell Death and Differentiation. 9: 93-5. PMID 11840157 DOI: 10.1038/Sj.Cdd.4400957  0.384
2002 Srinivasula SM, Datta P, Kobayashi M, Wu JW, Fujioka M, Hegde R, Zhang Z, Mukattash R, Fernandes-Alnemri T, Shi Y, Jaynes JB, Alnemri ES. sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein. Current Biology : Cb. 12: 125-30. PMID 11818063 DOI: 10.1016/S0960-9822(01)00657-1  0.451
2001 Wu JW, Hu M, Chai J, Seoane J, Huse M, Li C, Rigotti DJ, Kyin S, Muir TW, Fairman R, Massagué J, Shi Y. Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling. Molecular Cell. 8: 1277-89. PMID 11779503 DOI: 10.1016/S1097-2765(01)00421-X  0.536
2001 Fesik SW, Shi Y. Structural biology. Controlling the caspases. Science (New York, N.Y.). 294: 1477-8. PMID 11711663 DOI: 10.1126/Science.1062236  0.411
2001 Chai J, Wu Q, Shiozaki E, Srinivasula SM, Alnemri ES, Shi Y. Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding. Cell. 107: 399-407. PMID 11701129 DOI: 10.1016/S0092-8674(01)00544-X  0.825
2001 Wu JW, Cocina AE, Chai J, Hay BA, Shi Y. Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides. Molecular Cell. 8: 95-104. PMID 11511363 DOI: 10.1016/S1097-2765(01)00282-9  0.596
2001 Shi Y. A structural view of mitochondria-mediated apoptosis Nature Structural Biology. 8: 394-401. PMID 11323712 DOI: 10.1038/87548  0.408
2001 Wu JW, Fairman R, Penry J, Shi Y. Formation of a stable heterodimer between Smad2 and Smad4. The Journal of Biological Chemistry. 276: 20688-94. PMID 11274206 DOI: 10.1074/Jbc.M100174200  0.349
2001 Chai J, Shiozaki E, Srinivasula SM, Wu Q, Datta P, Alnemri ES, Shi Y, Dataa P. Structural basis of caspase-7 inhibition by XIAP. Cell. 104: 769-80. PMID 11257230 DOI: 10.1016/S0092-8674(01)00272-0  0.824
2001 Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA, Robbins PD, Fernandes-Alnemri T, Shi Y, Alnemri ES. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature. 410: 112-6. PMID 11242052 DOI: 10.1038/35065125  0.812
2001 Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee R, Robbins PD, Fernandes-Alnemri T, Shi Y, Alnemri ES. Erratum: correction: A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis Nature. 411: 1081-1081. DOI: 10.1038/35082622  0.801
2000 Wu G, Chai J, Suber TL, Wu JW, Du C, Wang X, Shi Y. Structural basis of IAP recognition by Smac/DIABLO. Nature. 408: 1008-12. PMID 11140638 DOI: 10.1038/35050012  0.744
2000 Chai J, Du C, Wu JW, Kyin S, Wang X, Shi Y. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature. 406: 855-62. PMID 10972280 DOI: 10.1038/35022514  0.623
2000 Shi Y. Survivin structure: Crystal unclear Nature Structural Biology. 7: 620-623. PMID 10932241 DOI: 10.1038/77904  0.37
2000 Ha S, Walker D, Shi Y, Walker S. The 1.9 A crystal structure of Escherichia coli MurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis. Protein Science : a Publication of the Protein Society. 9: 1045-52. PMID 10892798 DOI: 10.1110/Ps.9.6.1045  0.399
1999 Song X, Shi Y, Zhu X, Chai J. [The application of chopping method for phacoemulsification of hard nucleus cataract]. [Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology. 35: 88-90. PMID 11835779  0.358
1999 Hua X, Miller ZA, Wu G, Shi Y, Lodish HF. Specificity in transforming growth factor beta-induced transcription of the plasminogen activator inhibitor-1 gene: interactions of promoter DNA, transcription factor muE3, and Smad proteins. Proceedings of the National Academy of Sciences of the United States of America. 96: 13130-5. PMID 10557285 DOI: 10.1073/Pnas.96.23.13130  0.303
1999 Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. 99: 323-34. PMID 10555148 DOI: 10.1016/S0092-8674(00)81663-3  0.663
1999 Qin H, Srinivasula SM, Wu G, Fernandes-Alnemri T, Alnemri ES, Shi Y. Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature. 399: 549-57. PMID 10376594 DOI: 10.1038/21124  0.677
1999 Yan SD, Shi Y, Zhu A, Fu J, Zhu H, Zhu Y, Gibson L, Stern E, Collison K, Al-Mohanna F, Ogawa S, Roher A, Clarke SG, Stern DM. Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity. The Journal of Biological Chemistry. 274: 2145-56. PMID 9890977 DOI: 10.1074/Jbc.274.4.2145  0.311
1998 Shi Y, Wang YF, Jayaraman L, Yang H, Massagué J, Pavletich NP. Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling Cell. 94: 585-594. PMID 9741623 DOI: 10.1016/S0092-8674(00)81600-1  0.667
1998 Chen YG, Hata A, Lo RS, Wotton D, Shi Y, Pavletich N, Massagué J. Determinants of specificity in TGF-β signal transduction Genes and Development. 12: 2144-2152. PMID 9679059 DOI: 10.1101/Gad.12.14.2144  0.64
1998 Lo RS, Chen YG, Shi Y, Pavletich NP, Massagué J. The L3 loop: A structural motif determining specific interactions between SMAD proteins and TGF-β receptors Embo Journal. 17: 996-1005. PMID 9463378 DOI: 10.1093/Emboj/17.4.996  0.605
1997 Kim YG, Shi Y, Berg JM, Chandrasegaran S. Site-specific cleavage of DNA-RNA hybrids by zinc finger/FokI cleavage domain fusions. Gene. 203: 43-9. PMID 9426005 DOI: 10.1016/S0378-1119(97)00489-7  0.555
1997 Shi Y, Hata A, Lo RS, Massagué J, Pavletich NP. A structural basis for mutational inactivation of the tumour suppressor Smad4 Nature. 388: 87-93. PMID 9214508 DOI: 10.1038/40431  0.659
1996 Shi Y, Berg JM. DNA unwinding induced by zinc finger protein binding. Biochemistry. 35: 3845-8. PMID 8620008 DOI: 10.1021/Bi952384P  0.583
1996 Berg JM, Shi Y. The galvanization of biology: a growing appreciation for the roles of zinc. Science (New York, N.Y.). 271: 1081-5. PMID 8599083 DOI: 10.1126/Science.271.5252.1081  0.594
1995 Shi Y, Berg JM. A direct comparison of the properties of natural and designed zinc-finger proteins. Chemistry & Biology. 2: 83-9. PMID 9383408 DOI: 10.1016/1074-5521(95)90280-5  0.586
1995 Shi Y, Berg JM. Specific DNA-RNA hybrid binding by zinc finger proteins. Science (New York, N.Y.). 268: 282-4. PMID 7536342 DOI: 10.1126/Science.7536342  0.546
1993 Shi Y, Beger RD, Berg JM. Metal binding properties of single amino acid deletion mutants of zinc finger peptides: studies using cobalt(II) as a spectroscopic probe. Biophysical Journal. 64: 749-53. PMID 8471726 DOI: 10.1016/S0006-3495(93)81435-8  0.517
1991 Ruppel A, Xing Y, Dell R, Numrich P, Shi YE. Schistosoma mansoni and S. japonicum: decline of antibodies against diagnostic adult worm antigens (Sm31/32) following praziquantel treatment of mice. Tropical Medicine and Parasitology : Official Organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft FüR Technische Zusammenarbeit (Gtz). 42: 325-31. PMID 1796226  0.353
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