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Thomas J. Silhavy - Publications

Affiliations: 
Molecular Biology Princeton University, Princeton, NJ 
Area:
bacterial genetics
Website:
http://www.princeton.edu/molbio/silhavy/

235 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Mikheyeva IV, Sun J, Huang KC, Silhavy TJ. Mechanism of outer membrane destabilization by global reduction of protein content. Nature Communications. 14: 5715. PMID 37714857 DOI: 10.1038/s41467-023-40396-6  0.392
2023 Mikheyeva IV, Sun J, Huang KC, Silhavy TJ. Mechanism of outer membrane destabilization by global reduction of protein content. Biorxiv : the Preprint Server For Biology. PMID 36865163 DOI: 10.1101/2023.02.19.529137  0.384
2022 Combs AN, Silhavy TJ. The sacrificial adaptor protein Skp functions to remove stalled substrates from the β-barrel assembly machine. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 34969846 DOI: 10.1073/pnas.2114997119  0.326
2020 Hart EM, Silhavy TJ. Functions of the BamBCDE lipoproteins revealed by bypass mutations in BamA. Journal of Bacteriology. PMID 32817097 DOI: 10.1128/Jb.00401-20  0.493
2020 Hart EM, Gupta M, Wühr M, Silhavy TJ. The gain-of-function allele bypasses the essential requirement for BamD in β-barrel outer membrane protein assembly. Proceedings of the National Academy of Sciences of the United States of America. PMID 32675245 DOI: 10.1073/Pnas.2007696117  0.465
2020 Guest RL, Samé Guerra D, Wissler M, Grimm J, Silhavy TJ. YejM Modulates Activity of the YciM/FtsH Protease Complex To Prevent Lethal Accumulation of Lipopolysaccharide. Mbio. 11. PMID 32291302 DOI: 10.1128/Mbio.00598-20  0.366
2019 Hart EM, Mitchell AM, Konovalova A, Grabowicz M, Sheng J, Han X, Rodriguez-Rivera FP, Schwaid AG, Malinverni JC, Balibar CJ, Bodea S, Si Q, Wang H, Homsher MF, Painter RE, ... ... Silhavy TJ, et al. A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier. Proceedings of the National Academy of Sciences of the United States of America. PMID 31591200 DOI: 10.1073/Pnas.1912345116  0.819
2019 Mitchell AM, Silhavy TJ. Envelope stress responses: balancing damage repair and toxicity. Nature Reviews. Microbiology. PMID 31150012 DOI: 10.1038/S41579-019-0199-0  0.363
2019 Hart EM, Gupta M, Wühr M, Silhavy TJ. The Synthetic Phenotype of Δ Δ Double Mutants Results from a Lethal Jamming of the Bam Complex by the Lipoprotein RcsF. Mbio. 10. PMID 31113901 DOI: 10.1128/Mbio.00662-19  0.495
2019 Ricci DP, Silhavy TJ. Outer Membrane Protein Insertion by the β-barrel Assembly Machine. Ecosal Plus. 8. PMID 30869065 DOI: 10.1128/ecosalplus.ESP-0035-2018  0.781
2019 Hart EM, O'Connell A, Tang K, Wzorek JS, Grabowicz M, Kahne D, Silhavy TJ. Fine tuning of σ activation suppresses multiple assembly-defective mutations in . Journal of Bacteriology. PMID 30858299 DOI: 10.1128/Jb.00745-18  0.429
2019 Silhavy TJ, Mitchell AM. Genetic Analysis of Protein Translocation. The Protein Journal. PMID 30684070 DOI: 10.1007/S10930-019-09813-Y  0.475
2018 Mitchell AM, Srikumar T, Silhavy TJ. Cyclic Enterobacterial Common Antigen Maintains the Outer Membrane Permeability Barrier of Escherichia coli in a Manner Controlled by YhdP. Mbio. 9. PMID 30087168 DOI: 10.1128/Mbio.01321-18  0.459
2018 Konovalova A, Grabowicz M, Balibar CJ, Malinverni JC, Painter RE, Riley D, Mann PA, Wang H, Garlisi CG, Sherborne B, Rigel NW, Ricci DP, Black TA, Roemer T, Silhavy TJ, et al. Inhibitor of intramembrane protease RseP blocks the σ response causing lethal accumulation of unfolded outer membrane proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 29941590 DOI: 10.1073/Pnas.1806107115  0.804
2018 May KL, Silhavy TJ. Erratum for May and Silhavy, "The Escherichia coli Phospholipase PldA Regulates Outer Membrane Homeostasis via Lipid Signaling". Mbio. 9. PMID 29717014 DOI: 10.1128/Mbio.00718-18  0.379
2018 May KL, Silhavy TJ. ThePhospholipase PldA Regulates Outer Membrane Homeostasis via Lipid Signaling. Mbio. 9. PMID 29559571 DOI: 10.1128/Mbio.00379-18  0.385
2018 Lee J, Sutterlin HA, Wzorek JS, Mandler MD, Hagan CL, Grabowicz M, Tomasek D, May MD, Hart EM, Silhavy TJ, Kahne D. Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463713 DOI: 10.1073/Pnas.1711727115  0.815
2017 Rowland EA, Greco TM, Snowden CK, McCabe AL, Silhavy TJ, Cristea IM. Sirtuin Lipoamidase Activity Is Conserved in Bacteria as a Regulator of Metabolic Enzyme Complexes. Mbio. 8. PMID 28900027 DOI: 10.1128/Mbio.01096-17  0.389
2017 Konovalova A, Kahne DE, Silhavy TJ. Outer Membrane Biogenesis. Annual Review of Microbiology. 71: 539-556. PMID 28886680 DOI: 10.1146/Annurev-Micro-090816-093754  0.449
2017 Soltes GR, Martin NR, Park E, Sutterlin HA, Silhavy TJ. Distinctive roles for periplasmic proteases in the maintenance of essential outer membrane protein assembly. Journal of Bacteriology. PMID 28784813 DOI: 10.1128/Jb.00418-17  0.819
2017 McCabe AL, Ricci D, Adetunji M, Silhavy TJ. Conformational changes that coordinate the activity of BamA and BamD allowing β-barrel assembly. Journal of Bacteriology. PMID 28760846 DOI: 10.1128/Jb.00373-17  0.798
2017 Grabowicz M, Silhavy TJ. Redefining the essential trafficking pathway for outer membrane lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 28416660 DOI: 10.1073/Pnas.1702248114  0.445
2016 Grabowicz M, Silhavy TJ. Envelope Stress Responses: An Interconnected Safety Net. Trends in Biochemical Sciences. PMID 27839654 DOI: 10.1016/J.Tibs.2016.10.002  0.302
2016 Mitchell AM, Wang W, Silhavy TJ. Novel RpoS-dependent mechanisms strengthen the envelope permeability barrier during stationary phase. Journal of Bacteriology. PMID 27821607 DOI: 10.1128/Jb.00708-16  0.33
2016 May KL, Silhavy TJ. Making a membrane on the other side of the wall. Biochimica Et Biophysica Acta. PMID 27742351 DOI: 10.1016/J.Bbalip.2016.10.004  0.398
2016 Lee J, Xue M, Wzorek JS, Wu T, Grabowicz M, Gronenberg LS, Sutterlin HA, Davis RM, Ruiz N, Silhavy TJ, Kahne DE. Characterization of a stalled complex on the β-barrel assembly machine. Proceedings of the National Academy of Sciences of the United States of America. PMID 27439868 DOI: 10.1073/Pnas.1604100113  0.811
2016 Konovalova A, Schwalm JA, Silhavy TJ. A suppressor mutation that creates a faster and more robust σE envelope stress response. Journal of Bacteriology. PMID 27325680 DOI: 10.1128/Jb.00340-16  0.798
2016 Konovalova A, Mitchell AM, Silhavy TJ. A lipoprotein/β-barrel complex monitors lipopolysaccharide integrity transducing information across the outer membrane. Elife. 5. PMID 27282389 DOI: 10.7554/Elife.15276  0.393
2016 Mahoney TF, Ricci DP, Silhavy TJ. Classifying β-Barrel Assembly Substrates by Manipulating Essential Bam Complex Members. Journal of Bacteriology. PMID 27161117 DOI: 10.1128/Jb.00263-16  0.8
2016 Grabowicz M, Koren D, Silhavy TJ. The CpxQ sRNA Negatively Regulates Skp To Prevent Mistargeting of β-Barrel Outer Membrane Proteins into the Cytoplasmic Membrane. Mbio. 7. PMID 27048800 DOI: 10.1128/Mbio.00312-16  0.46
2016 Okuda S, Sherman DJ, Silhavy TJ, Ruiz N, Kahne D. Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model. Nature Reviews. Microbiology. PMID 27026255 DOI: 10.1038/Nrmicro.2016.25  0.404
2016 Sutterlin HA, Shi H, May KL, Miguel A, Khare S, Huang KC, Silhavy TJ. Disruption of lipid homeostasis in the Gram-negative cell envelope activates a novel cell death pathway. Proceedings of the National Academy of Sciences of the United States of America. PMID 26929379 DOI: 10.1073/Pnas.1601375113  0.803
2016 Silhavy TJ. Classic Spotlight: a Very Pleiotropic Mutant. Journal of Bacteriology. 198: 371. PMID 26773136 DOI: 10.1128/Jb.00774-15  0.317
2016 Soltes GR, Schwalm J, Ricci DP, Silhavy TJ. The activity of Escherichia coli chaperone SurA is regulated by conformational changes involving a parvulin domain. Journal of Bacteriology. PMID 26728192 DOI: 10.1128/Jb.00889-15  0.807
2016 Silhavy TJ. Classic Spotlight: Gram-Negative Bacteria Have Two Membranes. Journal of Bacteriology. 198: 201. PMID 26715373 DOI: 10.1128/Jb.00599-15  0.357
2016 Konovalova A, Mitchell AM, Silhavy TJ. Author response: A lipoprotein/β-barrel complex monitors lipopolysaccharide integrity transducing information across the outer membrane Elife. DOI: 10.7554/Elife.15276.015  0.333
2015 Konovalova A, Silhavy TJ. Outer membrane lipoprotein biogenesis: Lol is not the end. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370. PMID 26370942 DOI: 10.1098/Rstb.2015.0030  0.412
2014 Grabowicz M, Andres D, Lebar MD, Malojčić G, Kahne D, Silhavy TJ. A mutant Escherichia coli that attaches peptidoglycan to lipopolysaccharide and displays cell wall on its surface. Elife. 3: e05334. PMID 25551294 DOI: 10.7554/Elife.05334  0.354
2014 Koyuncu E, Budayeva HG, Miteva YV, Ricci DP, Silhavy TJ, Shenk T, Cristea IM. Sirtuins are evolutionarily conserved viral restriction factors. Mbio. 5. PMID 25516616 DOI: 10.1128/Mbio.02249-14  0.738
2014 Konovalova A, Perlman DH, Cowles CE, Silhavy TJ. Transmembrane domain of surface-exposed outer membrane lipoprotein RcsF is threaded through the lumen of β-barrel proteins. Proceedings of the National Academy of Sciences of the United States of America. 111: E4350-8. PMID 25267629 DOI: 10.1073/Pnas.1417138111  0.425
2014 Dwyer RS, Malinverni JC, Boyd D, Beckwith J, Silhavy TJ. Folding LacZ in the periplasm of Escherichia coli. Journal of Bacteriology. 196: 3343-50. PMID 25002543 DOI: 10.1128/Jb.01843-14  0.733
2014 Sutterlin HA, Zhang S, Silhavy TJ. Accumulation of phosphatidic acid increases vancomycin resistance in Escherichia coli. Journal of Bacteriology. 196: 3214-20. PMID 24957626 DOI: 10.1128/Jb.01876-14  0.806
2014 Malojčić G, Andres D, Grabowicz M, George AH, Ruiz N, Silhavy TJ, Kahne D. LptE binds to and alters the physical state of LPS to catalyze its assembly at the cell surface. Proceedings of the National Academy of Sciences of the United States of America. 111: 9467-72. PMID 24938785 DOI: 10.1073/Pnas.1402746111  0.353
2014 Zafar MA, Carabetta VJ, Mandel MJ, Silhavy TJ. Transcriptional occlusion caused by overlapping promoters. Proceedings of the National Academy of Sciences of the United States of America. 111: 1557-61. PMID 24474781 DOI: 10.1073/Pnas.1323413111  0.781
2014 Grabowicz M, Andres D, Lebar MD, Malojčić G, Kahne D, Silhavy TJ. Author response: A mutant Escherichia coli that attaches peptidoglycan to lipopolysaccharide and displays cell wall on its surface Elife. DOI: 10.7554/Elife.05334.011  0.325
2014 Dwyer RS, Malinverni JC, Boyd D, Beckwith J, Silhavy TJ. Folding LacZ in the periplasm of Escherichia coli Journal of Bacteriology. 196: 3343-3350. DOI: 10.1128/JB.01843-14  0.79
2013 Ricci DP, Schwalm J, Gonzales-Cope M, Silhavy TJ. The activity and specificity of the outer membrane protein chaperone SurA are modulated by a proline isomerase domain Mbio. 4. PMID 23943764 DOI: 10.1128/Mbio.00540-13  0.825
2013 Dwyer RS, Ricci DP, Colwell LJ, Silhavy TJ, Wingreen NS. Predicting functionally informative mutations in Escherichia coli BamA using evolutionary covariance analysis. Genetics. 195: 443-55. PMID 23934888 DOI: 10.1534/Genetics.113.155861  0.813
2013 Schwalm J, Mahoney TF, Soltes GR, Silhavy TJ. Role for Skp in LptD assembly in Escherichia coli. Journal of Bacteriology. 195: 3734-42. PMID 23772069 DOI: 10.1128/Jb.00431-13  0.821
2013 Rigel NW, Ricci DP, Silhavy TJ. Conformation-specific labeling of BamA and suppressor analysis suggest a cyclic mechanism for β-barrel assembly in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 110: 5151-5156. PMID 23479609 DOI: 10.1073/Pnas.1302662110  0.78
2013 Mahoney TF, Silhavy TJ. The Cpx stress response confers resistance to some, but not all, bactericidal antibiotics. Journal of Bacteriology. 195: 1869-74. PMID 23335416 DOI: 10.1128/Jb.02197-12  0.342
2013 Grabowicz M, Yeh J, Silhavy TJ. Dominant negative LptE mutation that supports a role for LptE as a plug in the LptD barrel Journal of Bacteriology. 195: 1327-1334. PMID 23316047 DOI: 10.1128/Jb.02142-12  0.436
2012 Denoncin K, Schwalm J, Vertommen D, Silhavy TJ, Collet JF. Dissecting the Escherichia coli periplasmic chaperone network using differential proteomics Proteomics. 12: 1391-1401. PMID 22589188 DOI: 10.1002/Pmic.201100633  0.835
2012 Peterson CN, Levchenko I, Rabinowitz JD, Baker TA, Silhavy TJ. RpoS proteolysis is controlled directly by ATP levels in Escherichia coli. Genes & Development. 26: 548-53. PMID 22426532 DOI: 10.1101/Gad.183517.111  0.738
2012 Ricci DP, Hagan CL, Kahne D, Silhavy TJ. Activation of the Escherichia coli β-barrel assembly machine (Bam) is required for essential components to interact properly with substrate Proceedings of the National Academy of Sciences of the United States of America. 109: 3487-3491. PMID 22331884 DOI: 10.1073/Pnas.1201362109  0.821
2012 Rigel NW, Silhavy TJ. Making a beta-barrel: Assembly of outer membrane proteins in Gram-negative bacteria Current Opinion in Microbiology. 15: 189-193. PMID 22221898 DOI: 10.1016/J.Mib.2011.12.007  0.457
2012 Rigel NW, Schwalm J, Ricci DP, Silhavy TJ. BamE modulates the Escherichia coli beta-barrel assembly machine component BamA Journal of Bacteriology. 194: 1002-1008. PMID 22178970 DOI: 10.1128/Jb.06426-11  0.829
2012 Ricci DP, Silhavy TJ. The Bam machine: A molecular cooper Biochimica Et Biophysica Acta - Biomembranes. 1818: 1067-1084. PMID 21893027 DOI: 10.1016/J.Bbamem.2011.08.020  0.791
2011 Malinverni JC, Silhavy TJ. Assembly of Outer Membrane β-Barrel Proteins: the Bam Complex. Ecosal Plus. 4. PMID 26442509 DOI: 10.1128/ecosalplus.4.3.8  0.4
2011 Malinverni JC, Silhavy TJ. Assembly of Outer Membrane β-Barrel Proteins: the Bam Complex. Ecosal Plus. 2011. PMID 25401113 DOI: 10.1128/ecosalplus.4.3.8  0.302
2011 Hagan CL, Silhavy TJ, Kahne D. β-barrel membrane protein assembly by the bam complex Annual Review of Biochemistry. 80: 189-210. PMID 21370981 DOI: 10.1146/Annurev-Biochem-061408-144611  0.49
2011 Chimalakonda G, Ruiz N, Chng SS, Garner RA, Kahne D, Silhavy TJ. Lipoprotein LptE is required for the assembly of LptD by the beta-barrel assembly machine in the outer membrane of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 108: 2492-7. PMID 21257909 DOI: 10.1073/Pnas.1019089108  0.45
2011 Cowles CE, Li Y, Semmelhack MF, Cristea IM, Silhavy TJ. The free and bound forms of Lpp occupy distinct subcellular locations in Escherichia coli Molecular Microbiology. 79: 1168-1181. PMID 21219470 DOI: 10.1111/J.1365-2958.2011.07539.X  0.337
2010 Ruiz N, Chng SS, Hinikera A, Kahne D, Silhavy TJ. Nonconsecutive disulfide bond formation in an essential integral outer membrane protein Proceedings of the National Academy of Sciences of the United States of America. 107: 12245-12250. PMID 20566849 DOI: 10.1073/Pnas.1007319107  0.438
2010 Carabetta VJ, Silhavy TJ, Cristea IM. The response regulator SprE (RssB) is required for maintaining poly(A) polymerase I-degradosome association during stationary phase Journal of Bacteriology. 192: 3713-3721. PMID 20472786 DOI: 10.1128/Jb.00300-10  0.767
2010 Silhavy TJ, Kahne D, Walker S. The bacterial cell envelope. Cold Spring Harbor Perspectives in Biology. 2: a000414. PMID 20452953 DOI: 10.1101/Cshperspect.A000414  0.345
2010 Chng SS, Ruiz N, Chimalakonda G, Silhavy TJ, Kahne D. Characterization of the two-protein complex in Escherichia coli responsible for lipopolysaccharide assembly at the outer membrane. Proceedings of the National Academy of Sciences of the United States of America. 107: 5363-8. PMID 20203010 DOI: 10.1073/Pnas.0912872107  0.415
2009 Carabetta VJ, Mohanty BK, Kushner SR, Silhavy TJ. The response regulator SprE (RssB) modulates polyadenylation and mRNA stability in Escherichia coli Journal of Bacteriology. 191: 6812-6821. PMID 19767441 DOI: 10.1128/Jb.00870-09  0.765
2009 van Stelten J, Silva F, Belin D, Silhavy TJ. Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY. Science (New York, N.Y.). 325: 753-6. PMID 19661432 DOI: 10.1126/Science.1172221  0.801
2009 Ruiz N, Kahne D, Silhavy TJ. Transport of lipopolysaccharide across the cell envelope: The long road of discovery Nature Reviews Microbiology. 7: 677-683. PMID 19633680 DOI: 10.1038/Nrmicro2184  0.316
2009 Malinverni JC, Silhavy TJ. An ABC transport system that maintains lipid asymmetry in the Gram-negative outer membrane Proceedings of the National Academy of Sciences of the United States of America. 106: 8009-8014. PMID 19383799 DOI: 10.1073/Pnas.0903229106  0.428
2009 Vertommen D, Ruiz N, Leverrier P, Silhavy TJ, Collet JF. Characterization of the role of the escherichia coli periplasmic chaperone SurA using differential proteomics Proteomics. 9: 2432-2443. PMID 19343722 DOI: 10.1002/Pmic.200800794  0.438
2008 Aoki SK, Malinverni JC, Jacoby K, Thomas B, Pamma R, Trinh BN, Remers S, Webb J, Braaten BA, Silhavy TJ, Low DA. Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB. Molecular Microbiology. 70: 323-40. PMID 18761695 DOI: 10.1111/J.1365-2958.2008.06404.X  0.48
2008 Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Dehò G, Silhavy TJ, Polissi A. Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli Journal of Bacteriology. 190: 4460-4469. PMID 18424520 DOI: 10.1128/Jb.00270-08  0.777
2008 Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ. Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 105: 5537-42. PMID 18375759 DOI: 10.1073/Pnas.0801196105  0.391
2007 Sklar JG, Wu T, Kahne D, Silhavy TJ. Defining the roles of the periplasmic chaperones SurA, Skp, and DegP in Escherichia coli Genes and Development. 21: 2473-2484. PMID 17908933 DOI: 10.1101/Gad.1581007  0.834
2007 Schmidt O, Schuenemann VJ, Hand NJ, Silhavy TJ, Martin J, Lupas AN, Djuranovic S. prlF and yhaV Encode a New Toxin-Antitoxin System in Escherichia coli Journal of Molecular Biology. 372: 894-905. PMID 17706670 DOI: 10.1016/J.Jmb.2007.07.016  0.725
2007 Kim S, Malinverni JC, Sliz P, Silhavy TJ, Harrison SC, Kahne D. Structure and function of an essential component of the outer membrane protein assembly machine. Science (New York, N.Y.). 317: 961-4. PMID 17702946 DOI: 10.1126/Science.1143993  0.442
2007 Sklar JG, Wu T, Gronenberg LS, Malinverni JC, Kahne D, Silhavy TJ. Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 104: 6400-5. PMID 17404237 DOI: 10.1073/Pnas.0701579104  0.834
2007 Fredriksson A, Ballesteros M, Peterson CN, Persson O, Silhavy TJ, Nyström T. Decline in ribosomal fidelity contributes to the accumulation and stabilization of the master stress response regulator σS upon carbon starvation Genes and Development. 21: 862-874. PMID 17403784 DOI: 10.1101/Gad.409407  0.723
2007 Button JE, Silhavy TJ, Ruiz N. A suppressor of cell death caused by the loss of σE downregulates extracytoplasmic stress responses and outer membrane vesicle production in Escherichia coli Journal of Bacteriology. 189: 1523-1530. PMID 17172327 DOI: 10.1128/Jb.01534-06  0.451
2007 Ureta AR, Endres RG, Wingreen NS, Silhavy TJ. Kinetic analysis of the assembly of the outer membrane protein LamB in Escherichia coli mutants each lacking a secretion or targeting factor in a different cellular compartment. Journal of Bacteriology. 189: 446-54. PMID 17071751 DOI: 10.1128/Jb.01103-06  0.485
2007 McCandlish AC, Silhavy TJ. Sugar-coating bacteria with lipopolysaccharides Microbe. 2: 289-295. DOI: 10.1128/Microbe.2.289.1  0.731
2007 Malinverni J, Silhavy TJ. The Identification of the YaeT Complex and Its Role in the Assembly of Bacterial Outer Membrane β-Barrel Proteins Enzymes. 25: 129-149. DOI: 10.1016/S1874-6047(07)25006-1  0.44
2006 Ruiz N, Wu T, Kahne D, Silhavy TJ. Probing the barrier function of the outer membrane with chemical conditionality. Acs Chemical Biology. 1: 385-395. PMID 17163776 DOI: 10.1021/Cb600128V  0.461
2006 Gaal T, Mandel MJ, Silhavy TJ, Gourse RL. Crl facilitates RNA polymerase holoenzyme formation. Journal of Bacteriology. 188: 7966-70. PMID 16980472 DOI: 10.1128/Jb.01266-06  0.653
2006 Wu T, McCandlish AC, Gronenberg LS, Chng SS, Silhavy TJ, Kahne D. Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 103: 11754-9. PMID 16861298 DOI: 10.1073/Pnas.0604744103  0.783
2006 Malinverni JC, Werner J, Kim S, Sklar JG, Kahne D, Misra R, Silhavy TJ. YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli Molecular Microbiology. 61: 151-164. PMID 16824102 DOI: 10.1111/J.1365-2958.2006.05211.X  0.831
2006 Peterson CN, Carabetta VJ, Chowdhury T, Silhavy TJ. LrhA regulates rpoS translation in response to the Rcs phosphorelay system in Escherichia coli Journal of Bacteriology. 188: 3175-3181. PMID 16621809 DOI: 10.1128/Jb.188.9.3175-3181.2006  0.809
2006 Silhavy TJ, Ruiz N, Kahne D. Advances in understanding bacterial outer-membrane biogenesis Nature Reviews Microbiology. 4: 57-66. PMID 16357861 DOI: 10.1038/Nrmicro1322  0.427
2005 Isaac DD, Pinkner JS, Hultgren SJ, Silhavy TJ. The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP Proceedings of the National Academy of Sciences of the United States of America. 102: 17775-17779. PMID 16303867 DOI: 10.1073/Pnas.0508936102  0.45
2005 Justice SS, Hunstad DA, Harper JR, Duguay AR, Pinkner JS, Bann J, Frieden C, Silhavy TJ, Hultgren SJ. Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli Journal of Bacteriology. 187: 7680-7686. PMID 16267292 DOI: 10.1128/Jb.187.22.7680-7686.2005  0.817
2005 Peterson CN, Mandel MJ, Silhavy TJ. Escherichia coli starvation diets: essential nutrients weigh in distinctly. Journal of Bacteriology. 187: 7549-53. PMID 16267278 DOI: 10.1128/Jb.187.22.7549-7553.2005  0.765
2005 Ruiz N, Falcone B, Kahne D, Silhavy TJ. Chemical conditionality: A genetic strategy to probe organelle assembly Cell. 121: 307-317. PMID 15851036 DOI: 10.1016/J.Cell.2005.02.014  0.426
2005 Wu T, Malinverni J, Ruiz N, Kim S, Silhavy TJ, Kahne D. Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli Cell. 121: 235-245. PMID 15851030 DOI: 10.1016/J.Cell.2005.02.015  0.494
2005 Ruiz N, Silhavy TJ. Sensing external stress: Watchdogs of the Escherichia coli cell envelope Current Opinion in Microbiology. 8: 122-126. PMID 15802241 DOI: 10.1016/J.Mib.2005.02.013  0.333
2005 Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, ... ... Silhavy TJ, et al. An open letter to Elias Zerhouni. Science (New York, N.Y.). 307: 1409-10. PMID 15746409 DOI: 10.1126/Science.307.5714.1409C  0.614
2005 Mandel MJ, Silhavy TJ. Starvation for different nutrients in Escherichia coli results in differential modulation of RpoS levels and stability. Journal of Bacteriology. 187: 434-42. PMID 15629914 DOI: 10.1128/Jb.187.2.434-442.2005  0.655
2004 Duguay AR, Silhavy TJ. Quality control in the bacterial periplasm Biochimica Et Biophysica Acta - Molecular Cell Research. 1694: 121-134. PMID 15546662 DOI: 10.1016/J.Bbamcr.2004.04.012  0.795
2004 Batchelor E, Silhavy TJ, Goulian M. Continuous control in bacterial regulatory circuits Journal of Bacteriology. 186: 7618-7625. PMID 15516575 DOI: 10.1128/Jb.186.22.7618-7625.2004  0.3
2004 Peterson CN, Ruiz N, Silhavy TJ. RpoS proteolysis is regulated by a mechanism that does not require the SprE (RssB) response regulator phosphorylation site Journal of Bacteriology. 186: 7403-7410. PMID 15489452 DOI: 10.1128/Jb.186.21.7403-7410.2004  0.71
2004 Gibbs KA, Isaac DD, Xu J, Hendrix RW, Silhavy TJ, Theriot JA. Complex spatial distribution and dynamics of an abundant Escherichia coli outer membrane protein, LamB. Molecular Microbiology. 53: 1771-83. PMID 15341654 DOI: 10.1111/J.1365-2958.2004.04242.X  0.394
2004 Lee YM, DiGiuseppe PA, Silhavy TJ, Hultgren SJ. P pilus assembly motif necessary for activation of the CpxRA pathway by PapE in Escherichia coli Journal of Bacteriology. 186: 4326-4337. PMID 15205435 DOI: 10.1128/Jb.186.13.4326-4337.2004  0.346
2003 Hand NJ, Silhavy TJ. Null Mutations in a Nudix Gene, ygdP, Implicate an Alarmone Response in a Novel Suppression of Hybrid Jamming Journal of Bacteriology. 185: 6530-6539. PMID 14594825 DOI: 10.1128/Jb.185.22.6530-6539.2003  0.743
2003 Ruiz N, Silhavy TJ. Constitutive activation of the Escherichia coli Pho regulon upregulates rpoS translation in an Hfq-dependent fashion Journal of Bacteriology. 185: 5984-5992. PMID 14526009 DOI: 10.1128/Jb.185.20.5984-5992.2003  0.429
2003 Bowers CW, Lau F, Silhavy TJ. Secretion of LamB-LacZ by the signal recognition particle pathway of Escherichia coli Journal of Bacteriology. 185: 5697-5705. PMID 13129940 DOI: 10.1128/Jb.185.19.5697-5705.2003  0.763
2003 Shuman HA, Silhavy TJ. The art and design of genetic screens: Escherichia coli Nature Reviews Genetics. 4: 419-431. PMID 12776212 DOI: 10.1038/Nrg1087  0.37
2003 DiGiuseppe PA, Silhavy TJ. Signal detection and target gene induction by the CpxRA two-component system Journal of Bacteriology. 185: 2432-2440. PMID 12670966 DOI: 10.1128/Jb.185.8.2432-2440.2003  0.375
2002 Duguay AR, Silhavy TJ. Signal sequence mutations as tools for the characterization of LamB folding intermediates Journal of Bacteriology. 184: 6918-6928. PMID 12446642 DOI: 10.1128/Jb.184.24.6918-6928.2002  0.803
2002 Braun M, Silhavy TJ. Imp/OstA is required for cell envelope biogenesis in Escherichia coli Molecular Microbiology. 45: 1289-1302. PMID 12207697 DOI: 10.1046/J.1365-2958.2002.03091.X  0.408
2002 Otto K, Silhavy TJ. Surface sensing and adhesion of Escherichia coli controlled by the Cpx-signaling pathway Proceedings of the National Academy of Sciences of the United States of America. 99: 2287-2292. PMID 11830644 DOI: 10.1073/Pnas.042521699  0.401
2001 Rizzitello AE, Harper JR, Silhavy TJ. Genetic evidence for parallel pathways of chaperone activity in the periplasm of Escherichia coli Journal of Bacteriology. 183: 6794-6800. PMID 11698367 DOI: 10.1128/Jb.183.23.6794-6800.2001  0.674
2001 Ruiz N, Peterson CN, Silhavy TJ. RpoS-dependent transcriptional control of sprE: Regulatory feedback loop Journal of Bacteriology. 183: 5974-5981. PMID 11566997 DOI: 10.1128/Jb.183.20.5974-5981.2001  0.722
2001 Raivio TL, Silhavy TJ. Periplasmic stress and ECF sigma factors Annual Review of Microbiology. 55: 591-624. PMID 11544368 DOI: 10.1146/Annurev.Micro.55.1.591  0.426
2001 Eggert US, Ruiz N, Falcone BV, Branstrom AA, Goldman RC, Silhavy TJ, Kahne D. Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin Science. 294: 361-364. PMID 11520949 DOI: 10.1126/Science.1063611  0.383
2001 Langen GR, Harper JR, Silhavy TJ, Howard SP. Absence of the outer membrane phospholipase a suppresses the temperature-sensitive phenotype of Escherichia coli degP mutants and induces the Cpx and σEextracytoplasmic stress responses Journal of Bacteriology. 183: 5230-5238. PMID 11514504 DOI: 10.1128/JB.183.18.5230-5238.2001  0.612
2001 Hung DL, Raivio TL, Jones CH, Silhavy TJ, Hultgren SJ. Cpx signaling pathway monitors biogenesis and affects assembly and expression of P pili Embo Journal. 20: 1508-1518. PMID 11285215 DOI: 10.1093/Emboj/20.7.1508  0.369
2000 Hand NJ, Silhavy TJ. A practical guide to the construction and use of lac fusions in Escherichia coli Methods in Enzymology. 326: 11-35. PMID 11036632 DOI: 10.1016/S0076-6879(00)26044-8  0.704
2000 Raivio TL, Laird MW, Joly JC, Silhavy TJ. Tethering of CpxP to the inner membrane prevents spheroplast induction of the cpx envelope stress response. Molecular Microbiology. 37: 1186-97. PMID 10972835 DOI: 10.1046/J.1365-2958.2000.02074.X  0.441
1999 Raivio TL, Popkin DL, Silhavy TJ. The Cpx envelope stress response is controlled by amplification and feedback inhibition Journal of Bacteriology. 181: 5263-5272. PMID 10464196 DOI: 10.1128/Jb.181.17.5263-5272.1999  0.435
1999 Harris CR, Silhavy TJ. Mapping an interface of SecY (PrlA) and SecE (PrlG) by using synthetic phenotypes and in vivo cross-linking Journal of Bacteriology. 181: 3438-3444. PMID 10348856 DOI: 10.1128/Jb.181.11.3438-3444.1999  0.46
1999 Raivio TL, Silhavy TJ. The σ(E) and Cpx regulatory pathways: Overlapping but distinct envelope stress responses Current Opinion in Microbiology. 2: 159-165. PMID 10322173 DOI: 10.1016/S1369-5274(99)80028-9  0.392
1999 Gibson KE, Silhavy TJ. The LysR homolog LrhA promotes RpoS degradation by modulating activity of the response regulator SprE Journal of Bacteriology. 181: 563-571. PMID 9882671 DOI: 10.1128/Jb.181.2.563-571.1999  0.39
1998 Danese PN, Silhavy TJ. Targeting and assembly of periplasmic and outer-membrane proteins in Escherichia coli Annual Review of Genetics. 32: 59-94. PMID 9928475 DOI: 10.1146/Annurev.Genet.32.1.59  0.463
1998 Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ. Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli Journal of Bacteriology. 180: 5875-5884. PMID 9811644 DOI: 10.1128/Jb.180.22.5875-5884.1998  0.46
1998 Pratt LA, Silhavy TJ. Crl stimulates RpoS activity during stationary phase Molecular Microbiology. 29: 1225-1236. PMID 9767590 DOI: 10.1046/J.1365-2958.1998.01007.X  0.365
1998 Hsing W, Russo FD, Bernd KK, Silhavy TJ. Mutations that alter the kinase and phosphatase activities of the two- component sensor EnvZ Journal of Bacteriology. 180: 4538-4546. PMID 9721293 DOI: 10.1128/Jb.180.17.4538-4546.1998  0.357
1998 Van Der Wolk JPW, Fekkes P, Boorsma A, Huie JL, Silhavy TJ, Driessen AJM. PrlA4 prevents the rejection of signal sequence defective preproteins by stabilizing the SecA-SecY interaction during the initiation of translocation Embo Journal. 17: 3631-3639. PMID 9649433 DOI: 10.1093/Emboj/17.13.3631  0.429
1998 Cosma CL, Crotwell MD, Burrows SY, Silhavy TJ. Folding-based suppression of extracytoplasmic toxicity conferred by processing-defective LamB. Journal of Bacteriology. 180: 3120-30. PMID 9620961 DOI: 10.1128/Jb.180.12.3120-3130.1998  0.492
1998 Danese PN, Silhavy TJ. CpxP, a stress-combative member of the Cpx regulon. Journal of Bacteriology. 180: 831-9. PMID 9473036 DOI: 10.1128/Jb.180.4.831-839.1998  0.416
1997 Raivio TL, Silhavy TJ. Transduction of envelope stress in Escherichia coli by the Cpx two-component system. Journal of Bacteriology. 179: 7724-33. PMID 9401031 DOI: 10.1128/Jb.179.24.7724-7733.1997  0.466
1997 Silhavy TJ. Death by lethal injection. Science (New York, N.Y.). 278: 1085-6. PMID 9381204 DOI: 10.1126/Science.278.5340.1085  0.388
1997 Jones CH, Danese PN, Pinkner JS, Silhavy TJ, Hultgren SJ. The chaperone-assisted membrane release and folding pathway is sensed by two signal transduction systems. The Embo Journal. 16: 6394-406. PMID 9351822 DOI: 10.1093/Emboj/16.21.6394  0.432
1997 Hsing W, Silhavy TJ. Function of conserved histidine-243 in phosphatase activity of EnvZ, the sensor for porin osmoregulation in Escherichia coli. Journal of Bacteriology. 179: 3729-35. PMID 9171423 DOI: 10.1128/Jb.179.11.3729-3735.1997  0.33
1997 Danese PN, Silhavy TJ. The sigma(E) and the Cpx signal transduction systems control the synthesis of periplasmic protein-folding enzymes in Escherichia coli. Genes & Development. 11: 1183-93. PMID 9159399 DOI: 10.1101/Gad.11.9.1183  0.449
1996 Pratt LA, Hsing W, Gibson KE, Silhavy TJ. From acids to osmZ: multiple factors influence synthesis of the OmpF and OmpC porins in Escherichia coli. Molecular Microbiology. 20: 911-7. PMID 8809744 DOI: 10.1111/J.1365-2958.1996.Tb02532.X  0.391
1996 Pratt LA, Silhavy TJ. The response regulator SprE controls the stability of RpoS. Proceedings of the National Academy of Sciences of the United States of America. 93: 2488-92. PMID 8637901 DOI: 10.1073/Pnas.93.6.2488  0.393
1995 Cosma CL, Danese PN, Carlson JH, Silhavy TJ, Snyder WB. Mutational activation of the Cpx signal transduction pathway of Escherichia coli suppresses the toxicity conferred by certain envelope-associated stresses. Molecular Microbiology. 18: 491-505. PMID 8748033 DOI: 10.1111/J.1365-2958.1995.Mmi_18030491.X  0.511
1995 Flower AM, Osborne RS, Silhavy TJ. The allele-specific synthetic lethality of prlA-prlG double mutants predicts interactive domains of SecY and SecE. The Embo Journal. 14: 884-93. PMID 7889938 DOI: 10.1002/J.1460-2075.1995.Tb07070.X  0.379
1995 Danese PN, Snyder WB, Cosma CL, Davis LJ, Silhavy TJ. The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP. Genes & Development. 9: 387-98. PMID 7883164 DOI: 10.1101/Gad.9.4.387  0.421
1995 Snyder WB, Silhavy TJ. Beta-galactosidase is inactivated by intermolecular disulfide bonds and is toxic when secreted to the periplasm of Escherichia coli. Journal of Bacteriology. 177: 953-63. PMID 7860606 DOI: 10.1128/Jb.177.4.953-963.1995  0.421
1995 Huie JL, Silhavy TJ. Suppression of signal sequence defects and azide resistance in Escherichia coli commonly result from the same mutations in secA. Journal of Bacteriology. 177: 3518-26. PMID 7768862 DOI: 10.1128/Jb.177.12.3518-3526.1995  0.433
1995 Danese PN, Murphy CK, Silhavy TJ. Multicopy suppression of cold-sensitive sec mutations in Escherichia coli. Journal of Bacteriology. 177: 4969-73. PMID 7665473 DOI: 10.1128/Jb.177.17.4969-4973.1995  0.459
1995 Snyder WB, Davis LJ, Danese PN, Cosma CL, Silhavy TJ. Overproduction of NlpE, a new outer membrane lipoprotein, suppresses the toxicity of periplasmic LacZ by activation of the Cpx signal transduction pathway. Journal of Bacteriology. 177: 4216-23. PMID 7635808 DOI: 10.1128/Jb.177.15.4216-4223.1995  0.479
1995 Kenney LJ, Bauer MD, Silhavy TJ. Phosphorylation-dependent conformational changes in OmpR, an osmoregulatory DNA-binding protein of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 92: 8866-70. PMID 7568033 DOI: 10.1073/Pnas.92.19.8866  0.355
1994 Flower AM, Doebele RC, Silhavy TJ. PrlA and PrlG suppressors reduce the requirement for signal sequence recognition. Journal of Bacteriology. 176: 5607-14. PMID 8083155 DOI: 10.1128/Jb.176.18.5607-5614.1994  0.432
1994 Pratt LA, Silhavy TJ. OmpR mutants specifically defective for transcriptional activation. Journal of Molecular Biology. 243: 579-94. PMID 7966283 DOI: 10.1016/0022-2836(94)90033-7  0.4
1993 Carlson JH, Silhavy TJ. Signal sequence processing is required for the assembly of LamB trimers in the outer membrane of Escherichia coli. Journal of Bacteriology. 175: 3327-34. PMID 8501036 DOI: 10.1128/Jb.175.11.3327-3334.1993  0.466
1993 Russo FD, Slauch JM, Silhavy TJ. Mutations that affect separate functions of OmpR the phosphorylated regulator of porin transcription in Escherichia coli. Journal of Molecular Biology. 231: 261-73. PMID 8389883 DOI: 10.1006/Jmbi.1993.1281  0.673
1993 Osborne RS, Silhavy TJ. PrlA suppressor mutations cluster in regions corresponding to three distinct topological domains. The Embo Journal. 12: 3391-8. PMID 8253067 DOI: 10.1002/J.1460-2075.1993.Tb06013.X  0.391
1993 Russo FD, Silhavy TJ. The essential tension: opposed reactions in bacterial two-component regulatory systems. Trends in Microbiology. 1: 306-10. PMID 8162415 DOI: 10.1016/0966-842X(93)90007-E  0.321
1992 Snyder WB, Silhavy TJ. Enhanced export of beta-galactosidase fusion proteins in prlF mutants is Lon dependent. Journal of Bacteriology. 174: 5661-8. PMID 1512198 DOI: 10.1128/Jb.174.17.5661-5668.1992  0.489
1992 Bieker-Brady K, Silhavy TJ. Suppressor analysis suggests a multistep, cyclic mechanism for protein secretion in Escherichia coli. The Embo Journal. 11: 3165-74. PMID 1387081 DOI: 10.1002/J.1460-2075.1992.Tb05393.X  0.486
1992 Geiger O, Russo FD, Silhavy TJ, Kennedy EP. Membrane-derived oligosaccharides affect porin osmoregulation only in media of low ionic strength. Journal of Bacteriology. 174: 1410-3. PMID 1370954 DOI: 10.1128/Jb.174.4.1410-1413.1992  0.368
1992 Phillips GJ, Silhavy TJ. The E. coli ffh gene is necessary for viability and efficient protein export. Nature. 359: 744-6. PMID 1331806 DOI: 10.1038/359744A0  0.418
1991 Schatz PJ, Bieker KL, Ottemann KM, Silhavy TJ, Beckwith J. One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. coli secretion machinery Embo Journal. 10: 1749-1757. PMID 2050112 DOI: 10.1002/J.1460-2075.1991.Tb07699.X  0.515
1991 Misra R, Peterson A, Ferenci T, Silhavy TJ. A genetic approach for analyzing the pathway of lamb assembly into the outer membrane of escherichia coli Journal of Biological Chemistry. 266: 13592-13597. PMID 1856196  0.323
1991 Bassford P, Beckwith J, Ito K, Kumamoto C, Mizushima S, Oliver D, Randall L, Silhavy T, Tai PC, Wickner B. The primary pathway of protein export in E. coli. Cell. 65: 367-8. PMID 1850320 DOI: 10.1016/0092-8674(91)90453-6  0.374
1991 Russo FD, Silhavy TJ. EnvZ controls the concentration of phosphorylated OmpR to mediate osmoregulation of the porin genes Journal of Molecular Biology. 222: 567-580. PMID 1660927 DOI: 10.1016/0022-2836(91)90497-T  0.34
1991 Slauch JM, Silhavy TJ. Genetic fusions as experimental tools Methods in Enzymology. 204: 213-248. PMID 1658562 DOI: 10.1016/0076-6879(91)04011-C  0.632
1991 Slauch JM, Russo FD, Silhavy TJ. Suppressor mutations in rpoA suggest that OmpR controls transcription by direct interaction with the α subunit of RNA polymerase Journal of Bacteriology. 173: 7501-7510. PMID 1657891 DOI: 10.1128/Jb.173.23.7501-7510.1991  0.652
1991 Slauch JM, Silhavy TJ. cis-Acting ompF mutations that result in OmpR-dependent constitutive expression Journal of Bacteriology. 173: 4039-4048. PMID 1648075 DOI: 10.1128/Jb.173.13.4039-4048.1991  0.669
1990 Bieker KL, Silhavy TJ. The genetics of protein secretion in E. coli Trends in Genetics. 6: 329-334. PMID 2281528 DOI: 10.1016/0168-9525(90)90254-4  0.425
1990 Bieker KL, Phillips GJ, Silhavy TJ. The sec and prl genes of Escherichia coli Journal of Bioenergetics and Biomembranes. 22: 291-310. PMID 2202721 DOI: 10.1007/Bf00763169  0.421
1990 Kiino DR, Phillips GJ, Silhavy TJ. Increased expression of the bifunctional protein PrlF suppresses overproduction lethality associated with exported β-galactosidase hybrid proteins in Escherichia coli Journal of Bacteriology. 172: 185-192. PMID 2152898  0.304
1990 Bieker KL, Silhavy TJ. PrlA (SecY) and PrlG (SecE) interact directly and function sequentially during protein translocation in E. coli Cell. 61: 833-842. PMID 2111734 DOI: 10.1016/0092-8674(90)90193-I  0.506
1990 Phillips GJ, Silhavy TJ. Heat-shock proteins DnaK and GroEL facilitate export of LacZ hybrid proteins in E. coli Nature. 344: 882-884. PMID 2109835 DOI: 10.1038/344882A0  0.413
1990 Igo MM, Slauch JM, Silhavy TJ. Signal transduction in bacteria: Kinases that control gene expression New Biologist. 2: 5-9. PMID 1964084  0.65
1989 Trun NJ, Silhavy TJ. The genetics of protein targeting in Escherichia coli K12 Journal of Cell Science. 93: 13-28. PMID 2693457 DOI: 10.1242/Jcs.1989.Supplement_11.2  0.494
1989 Stader J, Gansheroff LJ, Silhavy TJ. New suppressors of signal-sequence mutations, prlG, are linked tightly to the secE gene of Escherichia coli Genes & Development. 3: 1045-1052. PMID 2673921 DOI: 10.1101/Gad.3.7.1045  0.382
1989 Igo MM, Ninfa AJ, Silhavy TJ. A bacterial environmental sensor that functions as a protein kinase and stimulates transcriptional activation Genes & Development. 3: 598-605. PMID 2663643 DOI: 10.1101/Gad.3.5.598  0.323
1989 Slauch JM, Silhavy TJ. Genetic analysis of the switch that controls porin gene expression in Escherichia coli K-12 Journal of Molecular Biology. 210: 281-292. PMID 2557454 DOI: 10.1016/0022-2836(89)90330-6  0.713
1989 Trun NJ, Silhavy TJ. PrlC, a suppressor of signal sequence mutations in Escherichia coli, can direct the insertion of the signal sequence into the membrane Journal of Molecular Biology. 205: 665-676. PMID 2538634 DOI: 10.1016/0022-2836(89)90312-4  0.393
1989 Bieker KL, Silhavy TJ. PrlA is important for the translocation of exported proteins across the cytoplasmic membrane of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 86: 968-972. PMID 2536939 DOI: 10.1073/Pnas.86.3.968  0.495
1988 Stader J, Silhavy TJ. A progenitor of the outer membrane LamB trimer Journal of Bacteriology. 170: 1973-1974. PMID 3280555 DOI: 10.1128/Jb.170.4.1973-1974.1988  0.367
1988 Igo MM, Silhavy TJ. EnvZ, a transmembrane environmental sensor of Escherichia coli K-12, is phosphorylated in vitro Journal of Bacteriology. 170: 5971-5973. PMID 3056929 DOI: 10.1128/Jb.170.12.5971-5973.1988  0.368
1988 Trun NJ, Stader J, Lupas A, Kumamoto C, Silhavy TJ. Two cellular components, PrlA and SecB, that recognize different sequence determinants are required for efficient protein export Journal of Bacteriology. 170: 5928-5930. PMID 3056926 DOI: 10.1128/Jb.170.12.5928-5930.1988  0.412
1988 Bremer E, Silhavy TJ, Weinstock GM. Transposition of λplacMu is mediated by the A protein altered at its carboxy-terminal end Gene. 71: 177-186. PMID 2850974 DOI: 10.1016/0378-1119(88)90089-3  0.355
1988 Slauch JM, Garrett S, Jackson DE, Silhavy TJ. EnvZ functions through OmpR to control porin gene expression in Escherichia coli K-12 Journal of Bacteriology. 170: 439-441. PMID 2826400 DOI: 10.1128/Jb.170.1.439-441.1988  0.697
1987 Ferenci T, Silhavy TJ. Sequence information required for protein translocation from the cytoplasm Journal of Bacteriology. 169: 5339-5342. PMID 3316179 DOI: 10.1128/Jb.169.12.5339-5342.1987  0.34
1987 Rasmussen BA, Silhavy TJ. The first 28 amino acids of mature LamB are required for rapid and efficient export from the cytoplasm Genes & Development. 1: 185-196. PMID 2824280 DOI: 10.1101/Gad.1.2.185  0.413
1986 Bremer E, Silhavy TJ, Maldener M, Cole ST. Isolation and characterization of mutants deleted for the sulA-ompA region of the Escherichia coli K-12 chromosome Fems Microbiology Letters. 33: 173-178. DOI: 10.1111/J.1574-6968.1986.Tb01266.X  0.33
1985 Benson SA, Hall MN, Silhavy TJ. Genetic analysis of protein export in Escherichia coli K12. Annual Review of Biochemistry. 54: 101-34. PMID 3896116 DOI: 10.1146/Annurev.Bi.54.070185.000533  0.34
1985 Palva ET, Saris P, Silhavy TJ. Gene fusions to the ptsM/pel locus of Escherichia coli Mgg Molecular & General Genetics. 199: 427-433. PMID 3162078 DOI: 10.1007/Bf00330754  0.374
1985 Silhavy TJ, Beckwith JR. Uses of lac fusions for the study of biological problems. Microbiological Reviews. 49: 398-418. PMID 3005818 DOI: 10.1128/Mmbr.49.4.398-418.1985  0.633
1985 Sodergren EJ, Davidson J, Taylor RK, Silhavy TJ. Selection for mutants altered in the expression or export of outer membrane porin OmpF Journal of Bacteriology. 162: 1047-1053. PMID 2987179  0.367
1984 Benson SA, Bremer E, Silhavy TJ. Intragenic regions required for LamB export Proceedings of the National Academy of Sciences of the United States of America. 81: 3830-3834. PMID 6374667 DOI: 10.1073/Pnas.81.12.3830  0.419
1984 Palva ET, Silhavy TJ. lacZ fusions to genes that specify exported proteins: A general technique Mgg Molecular & General Genetics. 194: 388-394. PMID 6330498 DOI: 10.1007/Bf00425549  0.436
1984 Bremer E, Silhavy TJ, Weisemann JM, Weinstock GM. λ placMu: A transposable derivative of bacteriophage lambda for creating lacZ protein fusions in a single step Journal of Bacteriology. 158: 1084-1093. PMID 6327627 DOI: 10.1128/Jb.158.3.1084-1093.1984  0.394
1984 Lopilato JE, Garwin JL, Emr SD, Silhavy TJ, Beckwith JR. D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport. Journal of Bacteriology. 158: 665-73. PMID 6327616 DOI: 10.1128/Jb.158.2.665-673.1984  0.782
1984 Kiino DR, Silhavy TJ. Mutation prlF1 relieves the lethality associated with export of β-galactosidase hybrid proteins in Escherichia coli Journal of Bacteriology. 158: 878-883. PMID 6233268  0.306
1983 Silhavy TJ, Benson SA, Emr SD. Mechanisms of protein localization. Microbiological Reviews. 47: 313-44. PMID 6355805 DOI: 10.1128/Mmbr.47.3.313-344.1983  0.649
1983 Benson SA, Silhavy TJ. Information within the mature LamB protein necessary for localization to the outer membrane of E coli K12 Cell. 32: 1325-1335. PMID 6340836 DOI: 10.1016/0092-8674(83)90313-6  0.46
1983 Garrett S, Taylor RK, Silhavy TJ. Isolation and characterization of chain-terminating nonsense mutations in a porin regulator gene, envZ Journal of Bacteriology. 156: 62-69. PMID 6311806 DOI: 10.1128/Jb.156.1.62-69.1983  0.431
1983 Weinstock GM, Ap Rhys C, Berman ML, Hampar B, Jackson D, Silhavy TJ, Weisemann J, Zweig M. Open reading frame expression vectors: A general method for antigen production in Escherichia coli using protein fusions to β-galactosidase Proceedings of the National Academy of Sciences of the United States of America. 80: 4432-4436. PMID 6308625 DOI: 10.1073/Pnas.80.14.4432  0.421
1983 Taylor RK, Hall MN, Silhavy TJ, Gottesman M. Isolation and characterization of mutations altering expression of the major outer membrane porin proteins using the local anaesthetic procaine Journal of Molecular Biology. 166: 273-282. PMID 6304323 DOI: 10.1016/S0022-2836(83)80085-0  0.461
1983 Emr SD, Silhavy TJ. Importance of secondary structure in the signal sequence for protein secretion. Proceedings of the National Academy of Sciences of the United States of America. 80: 4599-603. PMID 6224220 DOI: 10.1073/Pnas.80.15.4599  0.722
1983 Benson SA, Silhavy TJ. Genetic Analysis of Protein Localization Cold Spring Harbor Monograph Archive. 15: 253-280. DOI: 10.1101/087969176.15.253  0.391
1983 Silhavy TJ, Beckwith J. [2] Isolation and characterization of mutants of Escherichia coli K12 affected in protein localization Methods in Enzymology. 97: 11-40. DOI: 10.1016/0076-6879(83)97115-X  0.726
1983 Beckwith J, Silhavy TJ. [1] Genetic analysis of protein export in Escherichia coli Methods in Enzymology. 97: 3-11. DOI: 10.1016/0076-6879(83)97114-8  0.737
1982 Emr SD, Silhavy TJ. Molecular components of the signal sequence that function in the initiation of protein export. The Journal of Cell Biology. 95: 689-96. PMID 6759512 DOI: 10.1083/Jcb.95.3.689  0.701
1982 Emr SD, Silhavy TJ. The signal hypothesis in bacteria. Progress in Clinical and Biological Research. 91: 3-14. PMID 6755484  0.601
1982 Shultz J, Silhavy TJ, Berman ML, Fiil N, Emr SD. A previously unidentified gene in the spc operon of Escherichia coli K12 specifies a component of the protein export machinery. Cell. 31: 227-35. PMID 6297749 DOI: 10.1016/0092-8674(82)90422-6  0.713
1982 Hall MN, Schwartz M, Silhavy TJ. Sequence information within the lamB gene is required for proper routing of the bacteriophage λ receptor protein to the outer membrane of Escherichia coli K-12 Journal of Molecular Biology. 156: 93-112. PMID 6212690 DOI: 10.1016/0022-2836(82)90461-2  0.45
1981 Hall MN, Silhavy TJ. Genetic analysis of the major outer membrane proteins of Escherichia coli Annual Review of Genetics. 15: 91-142. PMID 7039497 DOI: 10.1146/Annurev.Ge.15.120181.000515  0.433
1981 Bassford PJ, Emr SD, Silhavy TJ, Beckwith J, Beduelle H, Clément JM, Hedgpeth J, Hofnung M. The genetics of protein secretion in Escherichia coli. Methods in Cell Biology. 23: 27-38. PMID 7035805 DOI: 10.1016/S0091-679X(08)61489-2  0.725
1981 Hall MN, Silhavy TJ. The ompB locus and the regulation of the major outer membrane porin proteins of Escherichia coli K12 Journal of Molecular Biology. 146: 23-43. PMID 7021856 DOI: 10.1016/0022-2836(81)90364-8  0.474
1981 Emr SD, Hanley-Way S, Silhavy TJ. Suppressor mutations that restore export of a protein with a defective signal sequence. Cell. 23: 79-88. PMID 7011570 DOI: 10.1016/0092-8674(81)90272-5  0.727
1981 Hall MN, Silhavy TJ. Genetic analysis of the ompB locus in Escherichia coli K-12 Journal of Molecular Biology. 151: 1-15. PMID 6799653 DOI: 10.1016/0022-2836(81)90218-7  0.381
1980 Hall MN, Emr SD, Silhavy TJ. Genetic studies on mechanisms of protein localization in Escherichia coli K-12. Journal of Supramolecular Structure. 13: 147-63. PMID 7017277 DOI: 10.1002/Jss.400130203  0.747
1980 Moreno F, Fowler AV, Hall M, Silhavy TJ, Zabin I, Schwartz M. A signal sequence is not sufficient to lead beta-galactosidase out of the cytoplasm. Nature. 286: 356-9. PMID 6772962 DOI: 10.1038/286356A0  0.394
1980 Shuman HA, Silhavy TJ, Beckwith JR. Labeling of proteins with beta-galactosidase by gene fusion. Identification of a cytoplasmic membrane component of the Escherichia coli maltose transport system. The Journal of Biological Chemistry. 255: 168-74. PMID 6765939  0.702
1980 Emr SD, Silhavy TJ. Mutations affecting localization of an Escherichia coli outer membrane protein, the bacteriophage lambda receptor. Journal of Molecular Biology. 141: 63-90. PMID 6448927 DOI: 10.1016/S0022-2836(80)80029-5  0.737
1980 Emr SD, Hall MN, Silhavy TJ. A mechanism of protein localization: the signal hypothesis and bacteria. The Journal of Cell Biology. 86: 701-11. PMID 6447703 DOI: 10.1083/Jcb.86.3.701  0.738
1980 Emr SD, Hedgpeth J, Clément JM, Silhavy TJ, Hofnung M. Sequence analysis of mutations that prevent export of lambda receptor, an Escherichia coli outer membrane protein. Nature. 285: 82-5. PMID 6445509 DOI: 10.1038/285082A0  0.718
1980 Guarente LP, Isberg RR, Syvanen M, Silhavy TJ. Conferral of transposable properties to a chromosomal gene in Escherichia coli. Journal of Molecular Biology. 141: 235-48. PMID 6253648 DOI: 10.1016/0022-2836(80)90179-5  0.551
1980 Bassford P, Beckwith J, Berman M, Brickman E, Casadaban M, Guarente L, Saint-Girons I, Sarthy A, Schwartz M, Shuman H, Silhavy T. Genetic Fusions of the lac Operon: A New Approach to the Study of Biological Processes Cold Spring Harbor Monograph Archive. 7: 245-261. DOI: 10.1101/087969133.7.245  0.789
1979 Silhavy TJ, Brickman E, Bassford PJ, Casadaban MJ, Shuman HA, Schwartz V, Guarente L, Schwartz M, Beckwith JR. Structure of the malB region in Escherichia coli K12. II. Genetic map of the malE,F,G operon. Molecular & General Genetics : Mgg. 174: 249-59. PMID 384167 DOI: 10.1007/BF00267797  0.783
1979 Miki K, Silhavy TJ, Andrews KJ. Resolution of glpA and glpT loci into separate operons in Escherichia coli K-12 strains Journal of Bacteriology. 138: 268-269. PMID 374371 DOI: 10.1128/Jb.138.1.268-269.1979  0.3
1979 Hall MN, Silhavy TJ. Transcriptional regulation of Escherichia coli K-12 major outer membrane protein 1b Journal of Bacteriology. 140: 342-350. PMID 115844 DOI: 10.1128/Jb.140.2.342-350.1979  0.444
1979 Bassford PJ, Silhavy TJ, Beckwith JR. Use of gene fusion to study secretion of maltose-binding protein into Escherichia coli periplasm. Journal of Bacteriology. 139: 19-31. PMID 110778 DOI: 10.1128/Jb.139.1.19-31.1979  0.736
1979 Brickman E, Silhavy TJ, Bassford PJ, Shuman HA, Beckwith JR. Sites within gene lacZ of Escherichia coli for formation of active hybrid beta-galactosidase molecules. Journal of Bacteriology. 139: 13-8. PMID 110776 DOI: 10.1128/Jb.139.1.13-18.1979  0.691
1978 Argast M, Ludtke D, Silhavy TJ, Boos W. A second transport system for sn-glycerol-3-phosphate in Escherichia coli. Journal of Bacteriology. 136: 1070-83. PMID 363686  0.549
1978 Emr SD, Schwartz M, Silhavy TJ. Mutations altering the cellular localization of the phage lambda receptor, an Escherichia coli outer membrane protein. Proceedings of the National Academy of Sciences of the United States of America. 75: 5802-6. PMID 104291 DOI: 10.1073/Pnas.75.12.5802  0.728
1978 Débarbouillé M, Shuman HA, Silhavy TJ, Schwartz M. Dominant constitutive mutations in malT, the positive regulator gene of the maltose regulon in Escherichia coli Journal of Molecular Biology. 124: 359-371. PMID 101676 DOI: 10.1016/0022-2836(78)90304-2  0.384
1977 Silhavy TJ, Shuman HA, Beckwith J, Schwartz M. Use of gene fusions to study outer membrane protein localization in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 74: 5411-5415. PMID 414221 DOI: 10.1073/Pnas.74.12.5411  0.744
1976 Silhavy TJ, Casadaban MJ, Shuman HA, Beckwith JR. Conversion of beta-galactosidase to a membrane-bound state by gene fusion. Proceedings of the National Academy of Sciences of the United States of America. 73: 3423-7. PMID 790385 DOI: 10.1073/Pnas.73.10.3423  0.804
1976 Szmelcman S, Schwartz M, Silhavy TJ, Boos W. Maltose transport in Escherichia coli K12. A comparison of transport kinetics in wild-type and lambda-resistant mutants as measured by fluorescence quenching. European Journal of Biochemistry / Febs. 65: 13-9. PMID 776623 DOI: 10.1111/J.1432-1033.1976.Tb10383.X  0.53
1976 Silhavy TJ, Hartig-Beecken I, Boos W. Periplasmic protein related to the sn-glycerol-3-phosphate transport system of Escherichia coli. Journal of Bacteriology. 126: 951-8. PMID 770459 DOI: 10.1128/Jb.126.2.951-958.1976  0.554
1975 Silhavy TJ, Boos W. The "hidden ligand" of the galactose-binding protein. European Journal of Biochemistry / Febs. 54: 163-7. PMID 1097247 DOI: 10.1111/J.1432-1033.1975.Tb04125.X  0.522
1975 Silhavy TJ, Szmelcman S, Boos W, Schwartz M. On the significance of the retention of ligand by protein. Proceedings of the National Academy of Sciences of the United States of America. 72: 2120-4. PMID 1094454 DOI: 10.1073/Pnas.72.6.2120  0.559
1975 Johnson WC, Silhavy TJ, Boos W. Two-dimensional polyacylamide gel electrophoresis of envelope proteins of Escherichia coli. Applied Microbiology. 29: 405-13. PMID 803821  0.603
1974 Silhavy TJ, Boos W. Selection procedure for mutants defective in the beta-methylgalactoside transport system of Escherichia coli utilizing the compound 2R-glyceryl-beta-D-galactopyranoside. Journal of Bacteriology. 120: 424-32. PMID 4607764 DOI: 10.1128/Jb.120.1.424-432.1974  0.548
1974 McGowan EB, Silhavy TJ, Boos W. Involvement of a tryptophan residue in the binding site of Escherichia coli galactose-binding protein. Biochemistry. 13: 993-9. PMID 4591622 DOI: 10.1021/Bi00702A025  0.547
1973 Silhavy TJ, Boos W. A convenient synthesis of (2R)-glyceryl-beta-D-galactopyranoside. A substrate for beta-galactosidase, the lactose repressor, the galactose-binding protein, and the beta-methylgalactoside transport system. The Journal of Biological Chemistry. 248: 6571-4. PMID 4581106  0.457
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