Year |
Citation |
Score |
2021 |
Tomczyk MD, Zalewski M, Jørgensen PT, Wengel J, Walczak K. Polyamine-Oligonucleotide Conjugates: 2'-Me-Triazole-Linked 1,4,7,10-Tetraazacyclododecane and Intercalating Dyes and Their Effect on the Thermal Stability of DNA Duplexes. Pharmaceutics. 14. PMID 35056962 DOI: 10.3390/pharmaceutics14010066 |
0.316 |
|
2020 |
Gouda AS, Przypis Ł, Walczak K, Jørgensen PT, Wengel J. Carbazole modified oligonucleotides: synthesis, hybridization studies and fluorescence properties. Organic & Biomolecular Chemistry. 18: 6935-6948. PMID 32936176 DOI: 10.1039/d0ob01553a |
0.305 |
|
2020 |
Gouda AS, Przypis Ł, Walczak K, Jørgensen PT, Wengel J. Carbazole modified oligonucleotides: synthesis, hybridization studies and fluorescence properties. Organic & Biomolecular Chemistry. 18: 6935-6948. PMID 32936176 DOI: 10.1039/d0ob01553a |
0.305 |
|
2019 |
Danielsen MB, Lou C, Lisowiec-Wachnicka J, Pasternak A, Jørgensen PT, Wengel J. Gapmer antisense oligonucleotides containing 2',3'-dideoxy-2'-fluoro-3'-C-hydroxymethyl-β-D-lyxofuranosyl nucleotides display site-specific RNase H cleavage and induce gene silencing. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31682037 DOI: 10.1002/chem.201904540 |
0.314 |
|
2019 |
Xu Y, Gissberg O, Pabon-Martinez YV, Wengel J, Lundin KE, Smith CIE, Zain R, Nilsson L, Villa A. The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study. Plos One. 14: e0211651. PMID 30753192 DOI: 10.1371/Journal.Pone.0211651 |
0.323 |
|
2019 |
Kotkowiak W, Wengel J, Scotton CJ, Pasternak A. Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects. Journal of Medicinal Chemistry. 62: 2499-2507. PMID 30735377 DOI: 10.1021/acs.jmedchem.8b01806 |
0.315 |
|
2017 |
Pabon-Martinez YV, Xu Y, Villa A, Lundin KE, Geny S, Nguyen CH, Pedersen EB, Jørgensen PT, Wengel J, Nilsson L, Smith CIE, Zain R. LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures. Scientific Reports. 7: 11043. PMID 28887512 DOI: 10.1038/S41598-017-09147-8 |
0.33 |
|
2017 |
Vejlegaard K, Paul S, Kosbar T, Wengel J, Caruthers MH. Oligodeoxynucleotides containing 2'-amino-LNA nucleotides as constrained morpholino phosphoramidate and phosphorodiamidate monomers. Bioorganic & Medicinal Chemistry Letters. PMID 28552336 DOI: 10.1016/j.bmcl.2017.05.023 |
0.32 |
|
2017 |
Kumar R, Ries A, Wengel J. Synthesis and Excellent Duplex Stability of Oligonucleotides Containing 2'-Amino-LNA Functionalized with Galactose Units. Molecules (Basel, Switzerland). 22. PMID 28531137 DOI: 10.3390/molecules22050852 |
0.335 |
|
2017 |
Lou C, Samuelsen SV, Christensen NJ, Vester B, Wengel J. Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA. Bioconjugate Chemistry. PMID 28332825 DOI: 10.1021/acs.bioconjchem.7b00061 |
0.347 |
|
2016 |
Ries A, Kumar R, Lou C, Kosbar T, Vengut-Climent E, Jørgensen PT, Morales JC, Wengel J. Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA and 2'-Amino-LNA Monomers. The Journal of Organic Chemistry. PMID 27736097 DOI: 10.1021/acs.joc.6b01917 |
0.323 |
|
2014 |
Perlíková P, Ejlersen M, Langkjaer N, Wengel J. Bis-pyrene-modified unlocked nucleic acids: synthesis, hybridization studies, and fluorescent properties. Chemmedchem. 9: 2120-7. PMID 25044312 DOI: 10.1002/cmdc.201402185 |
0.322 |
|
2014 |
Perlíková P, Ejlersen M, Langkjaer N, Wengel J. Bis-pyrene-modified unlocked nucleic acids: synthesis, hybridization studies, and fluorescent properties. Chemmedchem. 9: 2120-7. PMID 25044312 DOI: 10.1002/cmdc.201402185 |
0.322 |
|
2014 |
Kauppinen S, Vester B, Wengel J. Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics. Drug Discovery Today. Technologies. 2: 287-90. PMID 24981949 DOI: 10.1016/j.ddtec.2005.08.012 |
0.324 |
|
2014 |
Astakhova IK, Wengel J. Scaffolding along nucleic acid duplexes using 2'-amino-locked nucleic acids. Accounts of Chemical Research. 47: 1768-77. PMID 24749544 DOI: 10.1021/ar500014g |
0.321 |
|
2014 |
Astakhova IK, Wengel J. Scaffolding along nucleic acid duplexes using 2'-amino-locked nucleic acids. Accounts of Chemical Research. 47: 1768-77. PMID 24749544 DOI: 10.1021/ar500014g |
0.321 |
|
2014 |
Perlíková P, Karlsen KK, Pedersen EB, Wengel J. Unlocked nucleic acids with a pyrene-modified uracil: synthesis, hybridization studies, fluorescent properties and i-motif stability. Chembiochem : a European Journal of Chemical Biology. 15: 146-56. PMID 24501777 DOI: 10.1002/cbic.201300567 |
0.33 |
|
2014 |
Perlíková P, Karlsen KK, Pedersen EB, Wengel J. Unlocked nucleic acids with a pyrene-modified uracil: synthesis, hybridization studies, fluorescent properties and i-motif stability. Chembiochem : a European Journal of Chemical Biology. 15: 146-56. PMID 24501777 DOI: 10.1002/cbic.201300567 |
0.33 |
|
2013 |
Sau SP, Madsen AS, Podbevsek P, Andersen NK, Kumar TS, Andersen S, Rathje RL, Anderson BA, Guenther DC, Karmakar S, Kumar P, Plavec J, Wengel J, Hrdlicka PJ. Identification and characterization of second-generation invader locked nucleic acids (LNAs) for mixed-sequence recognition of double-stranded DNA. The Journal of Organic Chemistry. 78: 9560-70. PMID 24032477 DOI: 10.1021/Jo4015936 |
0.343 |
|
2012 |
Crouzier L, Dubois C, Edwards SL, Lauridsen LH, Wengel J, Veedu RN. Efficient reverse transcription using locked nucleic acid nucleotides towards the evolution of nuclease resistant RNA aptamers Plos One. 7: e35990. PMID 22558297 |
0.306 |
|
2011 |
Pasternak A, Wengel J. Unlocked nucleic acid--an RNA modification with broad potential. Organic & Biomolecular Chemistry. 9: 3591-7. PMID 21431171 DOI: 10.1039/c0ob01085e |
0.339 |
|
2011 |
Hansen LH, Lobedanz S, Douthwaite S, Arar K, Wengel J, Kirpekar F, Vester B. Minimal substrate features for Erm methyltransferases defined by using a combinatorial oligonucleotide library. Chembiochem : a European Journal of Chemical Biology. 12: 610-4. PMID 21264994 DOI: 10.1002/cbic.201000606 |
0.302 |
|
2010 |
Pasternak A, Wengel J. Modulation of i-motif thermodynamic stability by the introduction of UNA (unlocked nucleic acid) monomers. Bioorganic & Medicinal Chemistry Letters. 21: 752-5. PMID 21185179 DOI: 10.1016/j.bmcl.2010.11.106 |
0.326 |
|
2010 |
Skov J, Bryld T, Lindegaard D, Nielsen KE, Højland T, Wengel J, Petersen M. Synthesis and structural characterization of piperazino-modified DNA that favours hybridization towards DNA over RNA. Nucleic Acids Research. 39: 1953-65. PMID 21062815 DOI: 10.1093/nar/gkq1123 |
0.319 |
|
2010 |
Veedu RN, Burri HV, Kumar P, Sharma PK, Hrdlicka PJ, Vester B, Wengel J. Polymerase-directed synthesis of C5-ethynyl locked nucleic acids. Bioorganic & Medicinal Chemistry Letters. 20: 6565-8. PMID 20932755 DOI: 10.1016/J.Bmcl.2010.09.044 |
0.329 |
|
2010 |
Laursen MB, Pakula MM, Gao S, Fluiter K, Mook OR, Baas F, Langklaer N, Wengel SL, Wengel J, Kjems J, Bramsen JB. Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo. Molecular Biosystems. 6: 862-70. PMID 20567772 DOI: 10.1039/B918869J |
0.326 |
|
2010 |
Pasternak A, Wengel J. Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides. Nucleic Acids Research. 38: 6697-706. PMID 20562222 DOI: 10.1093/nar/gkq561 |
0.3 |
|
2010 |
Gupta P, Langkjær N, Wengel J. Synthesis and biophysical studies of coronene functionalized 2'-amino-LNA: a novel class of fluorescent nucleic acids. Bioconjugate Chemistry. 21: 513-20. PMID 20099893 DOI: 10.1021/bc900421r |
0.308 |
|
2010 |
Karlsen KK, Jensen TB, Wengel J. Synthesis of an unlocked nucleic acid terpyridine monomer and binding of divalent metal ion in nucleic acid duplexes. The Journal of Organic Chemistry. 74: 8838-41. PMID 19863123 DOI: 10.1021/jo9019978 |
0.361 |
|
2010 |
Jensen TB, Langkjaer N, Wengel J. Unlocked nucleic acid (UNA) and UNA derivatives: thermal denaturation studies. Nucleic Acids Symposium Series (2004). 133-4. PMID 18776289 DOI: 10.1093/nass/nrn068 |
0.312 |
|
2009 |
Langkjaer N, Pasternak A, Wengel J. UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability. Bioorganic & Medicinal Chemistry. 17: 5420-5. PMID 19604699 DOI: 10.1016/j.bmc.2009.06.045 |
0.307 |
|
2009 |
Fluiter K, Mook OR, Vreijling J, Langkjaer N, Højland T, Wengel J, Baas F. Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4'-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer. Molecular Biosystems. 5: 838-43. PMID 19603119 DOI: 10.1039/b903922h |
0.305 |
|
2009 |
Umemoto T, Wengel J, Madsen AS. Functionalization of 2'-amino-LNA with additional nucleobases. Organic & Biomolecular Chemistry. 7: 1793-7. PMID 19590773 DOI: 10.1039/b901028a |
0.308 |
|
2009 |
Nagahama K, Veedu RN, Wengel J. Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides. Bioorganic & Medicinal Chemistry Letters. 19: 2707-9. PMID 19375912 DOI: 10.1016/j.bmcl.2009.03.116 |
0.327 |
|
2008 |
Kaur H, Arora A, Wengel J, Maiti S. Thermodynamic, counterion and hydration effects for the incorporation of locked nucleic acid (LNA) nucleotides in duplex. Nucleic Acids Symposium Series (2004). 425-6. PMID 18776435 DOI: 10.1093/nass/nrn216 |
0.336 |
|
2008 |
Kalek M, Benediktson P, Vester B, Wengel J. Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach. Chemical Communications (Cambridge, England). 762-4. PMID 18478716 DOI: 10.1039/B712532A |
0.615 |
|
2008 |
Kalek M, Benediktson P, Vester B, Wengel J. Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach. Chemical Communications (Cambridge, England). 762-4. PMID 18478716 DOI: 10.1039/B712532A |
0.615 |
|
2008 |
Vester B, Boel AM, Lobedanz S, Babu BR, Raunkjaer M, Lindegaard D, Raunak, Hrdlicka PJ, Højland T, Sharma PK, Kumar S, Nielsen P, Wengel J. Chemically modified oligonucleotides with efficient RNase H response. Bioorganic & Medicinal Chemistry Letters. 18: 2296-300. PMID 18356048 DOI: 10.1016/J.Bmcl.2008.03.004 |
0.309 |
|
2008 |
Kaur H, Wengel J, Maiti S. Thermodynamics of DNA-RNA heteroduplex formation: effects of locked nucleic acid nucleotides incorporated into the DNA strand. Biochemistry. 47: 1218-27. PMID 18171024 DOI: 10.1021/bi700996z |
0.355 |
|
2007 |
Umemoto T, Hrdlicka PJ, Babu BR, Wengel J. Dual-probe system using pyrenylmethyl-modified amino-LNA for mismatch detection. Nucleosides, Nucleotides & Nucleic Acids. 26: 1261-3. PMID 18066764 DOI: 10.1080/15257770701528255 |
0.312 |
|
2007 |
Umemoto T, Hrdlicka PJ, Babu BR, Wengel J. Sensitive SNP dual-probe assays based on pyrene-functionalized 2'-amino-LNA: lessons to be learned. Chembiochem : a European Journal of Chemical Biology. 8: 2240-8. PMID 17979173 DOI: 10.1002/Cbic.200700408 |
0.314 |
|
2007 |
Donini S, Clerici M, Wengel J, Vester B, Peracchi A. The advantages of being locked. Assessing the cleavage of short and long RNAs by locked nucleic acid-containing 8-17 deoxyribozymes. The Journal of Biological Chemistry. 282: 35510-8. PMID 17908692 DOI: 10.1074/jbc.M706993200 |
0.308 |
|
2007 |
Kalek M, Madsen AS, Wengel J. Effective modulation of DNA duplex stability by reversible transition metal complex formation in the minor groove. Journal of the American Chemical Society. 129: 9392-400. PMID 17616191 DOI: 10.1021/Ja071076Z |
0.604 |
|
2007 |
Kalek M, Madsen AS, Wengel J. Effective modulation of DNA duplex stability by reversible transition metal complex formation in the minor groove. Journal of the American Chemical Society. 129: 9392-400. PMID 17616191 DOI: 10.1021/Ja071076Z |
0.604 |
|
2006 |
Kaur H, Arora A, Wengel J, Maiti S. Thermodynamic, counterion, and hydration effects for the incorporation of locked nucleic acid nucleotides into DNA duplexes. Biochemistry. 45: 7347-55. PMID 16752924 DOI: 10.1021/bi060307w |
0.35 |
|
2006 |
Kalra N, Parlato MC, Parmar VS, Wengel J. DNA and LNA oligonucleotides containing N2'-functionalised derivatives of 2'-amino-2'-deoxyuridine. Bioorganic & Medicinal Chemistry Letters. 16: 3166-9. PMID 16621554 DOI: 10.1016/j.bmcl.2006.03.072 |
0.313 |
|
2006 |
Kauppinen S, Vester B, Wengel J. Locked nucleic acid: high-affinity targeting of complementary RNA for RNomics. Handbook of Experimental Pharmacology. 405-22. PMID 16594628 DOI: 10.1007/3-540-27262-3_21 |
0.311 |
|
2005 |
Babu BR, Hrdlicka PJ, McKenzie CJ, Wengel J. Optimized DNA targeting using N,N-bis(2-pyridylmethyl)-beta-alanyl 2'-amino-LNA. Chemical Communications (Cambridge, England). 1705-7. PMID 15791305 DOI: 10.1039/B417101B |
0.346 |
|
2005 |
Jepsen JS, Wengel J. LNA-antisense rivals siRNA for gene silencing. Current Opinion in Drug Discovery & Development. 7: 188-94. PMID 15603252 |
0.343 |
|
2005 |
Filichev VV, Christensen UB, Pedersen EB, Babu BR, Wengel J. Locked nucleic acids and intercalating nucleic acids in the design of easily denaturing nucleic acids: thermal stability studies. Chembiochem : a European Journal of Chemical Biology. 5: 1673-9. PMID 15532065 DOI: 10.1002/cbic.200400222 |
0.31 |
|
2004 |
Vester B, Wengel J. LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA. Biochemistry. 43: 13233-41. PMID 15491130 DOI: 10.1021/BI0485732 |
0.345 |
|
2004 |
Pfundheller HM, Sørensen AM, Lomholt C, Johansen AM, Koch T, Wengel J. Locked nucleic acid synthesis. Methods in Molecular Biology (Clifton, N.J.). 288: 127-46. PMID 15333901 DOI: 10.1385/1-59259-823-4:127 |
0.312 |
|
2004 |
Nielsen KE, Rasmussen J, Kumar R, Wengel J, Jacobsen JP, Petersen M. NMR studies of fully modified locked nucleic acid (LNA) hybrids: solution structure of an LNA:RNA hybrid and characterization of an LNA:DNA hybrid. Bioconjugate Chemistry. 15: 449-57. PMID 15149171 DOI: 10.1021/bc034145h |
0.319 |
|
2004 |
Vester B, Lundberg LB, Sørensen MD, Babu BR, Douthwaite S, Wengel J. Improved RNA cleavage by LNAzyme derivatives of DNAzymes. Biochemical Society Transactions. 32: 37-40. PMID 14748708 DOI: 10.1042/ |
0.313 |
|
2003 |
Lindegaard D, Wengel J. Synthesis and hybridization properties of oligodeoxynucleotides containing 3'-deoxy-3'-C-methyleneuridine. Nucleosides, Nucleotides & Nucleic Acids. 22: 1159-61. PMID 14565369 DOI: 10.1081/NCN-120022825 |
0.308 |
|
2003 |
Poopeiko NE, Juhl M, Vester B, Sørensen MD, Wengel J. Xylo-Configured oligonucleotides (XNA, xylo nucleic acid): synthesis of conformationally restricted derivatives and hybridization towards DNA and RNA complements. Bioorganic & Medicinal Chemistry Letters. 13: 2285-90. PMID 12824019 DOI: 10.1016/S0960-894X(03)00441-4 |
0.349 |
|
2003 |
Petersen M, Wengel J. LNA: a versatile tool for therapeutics and genomics. Trends in Biotechnology. 21: 74-81. PMID 12573856 DOI: 10.1016/S0167-7799(02)00038-0 |
0.348 |
|
2003 |
Lauritsen A, Dahl BM, Dahl O, Vester B, Wengel J. Methylphosphonate LNA: a locked nucleic acid with a methylphosphonate linkage. Bioorganic & Medicinal Chemistry Letters. 13: 253-6. PMID 12482433 DOI: 10.1016/S0960-894X(02)00882-X |
0.358 |
|
2003 |
Lauritsen A, Wengel J. Oligodeoxynucleotides containing amide-linked LNA-type dinucleotides: synthesis and high-affinity nucleic acid hybridization. Chemical Communications (Cambridge, England). 530-1. PMID 12120575 DOI: 10.1039/B111000D |
0.329 |
|
2002 |
Babu BR, Wengel J. Universal hybridization using LNA (locked nucleic acid) containing a novel pyrene LNA nucleotide monomer. Chemical Communications (Cambridge, England). 2114-5. PMID 12240189 DOI: 10.1039/B106065C |
0.335 |
|
2002 |
Petersen M, Bondensgaard K, Wengel J, Jacobsen JP. Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids. Journal of the American Chemical Society. 124: 5974-82. PMID 12022830 DOI: 10.1021/JA012288D |
0.301 |
|
2001 |
CHRISTENSEN U, JACOBSEN N, RAJWANSHI VK, WENGEL J, KOCH T. Stopped-flow kinetics of locked nucleic acid (LNA)–oligonucleotide duplex formation: studies of LNA–DNA and DNA–DNA interactions Biochemical Journal. 354: 481-484. DOI: 10.1042/BJ3540481 |
0.314 |
|
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