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Jianbin Ruan - Publications

Affiliations: 
Immunology University of Connecticut, Storrs, CT, United States 
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wright SS, Wang C, Ta A, Havira MS, Ruan J, Rathinam VA, Vanaja SK. A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis. Cell Reports. 43: 114004. PMID 38522070 DOI: 10.1016/j.celrep.2024.114004  0.384
2023 Wang C, Ruan J. An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis. Plos Biology. 21: e3002103. PMID 37141191 DOI: 10.1371/journal.pbio.3002103  0.303
2023 Wang C, Shivcharan S, Tian T, Wright S, Ma D, Chang J, Li K, Song K, Xu C, Rathinam VA, Ruan J. Structural basis for GSDMB pore formation and its targeting by IpaH7.8. Nature. PMID 36991122 DOI: 10.1038/s41586-023-05832-z  0.378
2021 Wang C, Ruan J. Mechanistic Insights into Gasdermin Pore Formation and Regulation in Pyroptosis. Journal of Molecular Biology. 434: 167297. PMID 34627790 DOI: 10.1016/j.jmb.2021.167297  0.456
2021 Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. PMID 33883744 DOI: 10.1038/s41586-021-03478-3  0.601
2021 Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H. Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nature Communications. 12: 189. PMID 33420033 DOI: 10.1038/s41467-020-20320-y  0.657
2020 Ruan J. Inflammasomes. Molecular Aspects of Medicine. 76: 100934. PMID 33218678 DOI: 10.1016/j.mam.2020.100934  0.328
2020 Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, et al. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nature Immunology. PMID 32367036 DOI: 10.1038/S41590-020-0669-6  0.421
2019 Ruan J. Structural Insight of Gasdermin Family Driving Pyroptotic Cell Death. Advances in Experimental Medicine and Biology. 1172: 189-205. PMID 31628657 DOI: 10.1007/978-981-13-9367-9_9  0.456
2019 Xia S, Ruan J, Wu H. Monitoring gasdermin pore formation in vitro. Methods in Enzymology. 625: 95-107. PMID 31455540 DOI: 10.1016/bs.mie.2019.04.024  0.472
2019 Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU. SERPINB1-mediated checkpoint of inflammatory caspase activation. Nature Immunology. PMID 30692621 DOI: 10.1038/s41590-018-0303-z  0.506
2019 Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H. Molecular mechanism for NLRP6 inflammasome assembly and activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30674671 DOI: 10.2210/Pdb6Ndj/Pdb  0.687
2018 Li Y, Fu TM, Lu A, Witt K, Ruan J, Shen C, Wu H. Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. Proceedings of the National Academy of Sciences of the United States of America. PMID 30279182 DOI: 10.1073/pnas.1810524115  0.701
2018 Ruan J, Xia S, Liu X, Lieberman J, Wu H. Cryo-EM structure of the gasdermin A3 membrane pore. Nature. PMID 29695864 DOI: 10.1038/s41586-018-0058-6  0.382
2018 Annibaldi A, Wicky John S, Vanden Berghe T, Swatek KN, Ruan J, Liccardi G, Bianchi K, Elliott PR, Choi SM, Van Coillie S, Bertin J, Wu H, Komander D, Vandenabeele P, Silke J, et al. Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. Molecular Cell. 69: 566-580.e5. PMID 29452637 DOI: 10.1016/J.Molcel.2018.01.027  0.356
2017 Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Immunity. PMID 29195811 DOI: 10.1016/J.Immuni.2017.11.013  0.392
2016 Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 535: 153-158. PMID 27383986 DOI: 10.1038/Nature18629  0.423
2016 Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science (New York, N.Y.). PMID 27103670 DOI: 10.1126/Science.Aaf3036  0.39
2016 Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. The Journal of Experimental Medicine. PMID 27069117 DOI: 10.1084/Jem.20151790  0.509
2015 Lu A, Li Y, Yin Q, Ruan J, Yu X, Egelman E, Wu H. Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2. Cell Discovery. 1. PMID 26583071 DOI: 10.1038/celldisc.2015.13  0.601
2015 Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H. Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science (New York, N.Y.). PMID 26449474 DOI: 10.1126/science.aac5789  0.63
2014 Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell. 156: 1193-206. PMID 24630722 DOI: 10.1016/J.Cell.2014.02.008  0.683
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