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Miguel A. Ondetti, Ph.D. - Publications

Affiliations: 
1960-1991 Chemistry Squibb Institute for Medical Research 
Area:
Captopril
Website:
https://www.acsmedchem.org/?nd=Ondetti
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
1999 Cushman DW, Ondetti MA. Design of angiotensin converting enzyme inhibitors. Nature Medicine. 5: 1110-3. PMID 10502801 DOI: 10.1038/13423  0.788
1991 Cushman DW, Ondetti MA. History of the design of captopril and related inhibitors of angiotensin converting enzyme. Hypertension. 17: 589-92. PMID 2013486  0.772
1991 Ondetti MA. Angiotensin converting enzyme inhibitors. An overview. Hypertension. 18: III134-5. PMID 1937676  0.566
1988 Ondetti MA. Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity. Circulation. 77: I74-8. PMID 2836111  0.501
1987 Petrillo EW, Powell JR, Cushman DW, Ondetti MA. Angiotensin-converting enzyme inhibitors: accomplishments and challenges. Clinical and Experimental Hypertension. Part a, Theory and Practice. 9: 235-41. PMID 3038385 DOI: 10.3109/10641968709164183  0.785
1987 Cushman DW, Ondetti MA, Gordon EM, Natarajan S, Karanewsky DS, Krapcho J, Petrillo EW. Rational design and biochemical utility of specific inhibitors of angiotensin-converting enzyme. Journal of Cardiovascular Pharmacology. 10: S17-30. PMID 2485059  0.766
1984 Ondetti MA, Cushman DW. Angiotensin-converting enzyme inhibitors: biochemical properties and biological actions. Crc Critical Reviews in Biochemistry. 16: 381-411. PMID 6094098  0.761
1983 Ondetti MA. Biochemistry of the renin-angiotensin system. Introduction. Federation Proceedings. 42: 2722-3. PMID 6305730  0.348
1982 Ondetti MA, Cushman DW. Enzymes of the renin-angiotensin system and their inhibitors. Annual Review of Biochemistry. 51: 283-308. PMID 6287916 DOI: 10.1146/Annurev.Bi.51.070182.001435  0.795
1982 Petrillo EW, Ondetti MA. Angiotensin-converting enzyme inhibitors: medicinal chemistry and biological actions. Medicinal Research Reviews. 2: 1-41. PMID 6287131 DOI: 10.1002/Med.2610020103  0.587
1982 Condon ME, Petrillo EW, Ryono DE, Reid JA, Neubeck R, Puar M, Heikes JE, Sabo EF, Losee KA, Cushman DW, Ondetti MA. Angiotensin-converting enzyme inhibitors: importance of the amide carbonyl of mercaptoacyl amino acids for hydrogen bonding to the enzyme. Journal of Medicinal Chemistry. 25: 250-8. PMID 6279843 DOI: 10.1002/Chin.198233150  0.731
1982 Cushman DW, Cheung HS, Sabo EF, Ondetti MA. Development and design of specific inhibitors of angiotensin-converting enzyme. The American Journal of Cardiology. 49: 1390-4. PMID 6176105 DOI: 10.1016/0002-9149(82)90348-4  0.801
1981 Georgopapadakou NH, Liu FY, Ryono DE, Neubeck R, Ondetti MA. Chemical modifications of the active site of Streptomyces R61 DD-carboxypeptidase. European Journal of Biochemistry / Febs. 115: 53-7. PMID 7227371 DOI: 10.1111/J.1432-1033.1981.Tb06196.X  0.429
1981 Ondetti MA, Cushman DW. Design of protease inhibitors. Biopolymers. 20: 2001-10. PMID 6272900 DOI: 10.1002/Bip.1981.360200922  0.715
1981 Ondetti MA, Cushman DW. Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension. Journal of Medicinal Chemistry. 24: 355-61. PMID 6267277 DOI: 10.1002/Chin.198134344  0.679
1981 Gordon EM, Pluščec J, Ondetti MA. Carbacyclic isosteres of penicillanic and carbapenemic acids. Synthesis of bicyclo[3.2.0]Heptan-6-ones as potential enzyme inhibitors. Tetrahedron Letters. 22: 1871-1874. DOI: 10.1016/S0040-4039(01)90464-2  0.501
1980 Cushman DW, Ondetti MA. Inhibitors of angiotensin-converting enzyme. Progress in Medicinal Chemistry. 17: 41-104. PMID 6273970 DOI: 10.1016/S0079-6468(08)70157-7  0.78
1980 Cushman DW, Ondetti MA, Cheung HS, Antonaccio MJ, Murthy VS, Rubin B. Inhibitors of angiotensin-converting enzyme. Advances in Experimental Medicine and Biology. 130: 199-225. PMID 6250340 DOI: 10.1007/978-1-4615-9173-3_8  0.787
1980 Cushman DW, Ondetti MA. Inhibitors of angiotensin-converting enzyme for treatment of hypertension. Biochemical Pharmacology. 29: 1871-7. PMID 6249323 DOI: 10.1016/0006-2952(80)90096-9  0.774
1980 Cheung HS, Wang FL, Ondetti MA, Sabo EF, Cushman DW. Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence. The Journal of Biological Chemistry. 255: 401-7. PMID 6243277  0.743
1980 Cushman DW, Ondetti MA. Control of blood pressure by angiotensin blockade Trends in Pharmacological Sciences. 1: 260-263. DOI: 10.1016/0165-6147(80)90015-2  0.635
1979 Ondetti MA, Condon ME, Reid J, Sabo EF, Cheung HS, Cushman DW. Design of potent and specific inhibitors of carboxypeptidases A and B. Biochemistry. 18: 1427-30. PMID 427123 DOI: 10.1021/Bi00575A006  0.713
1979 Cushman DW, Cheung HS, Sabo EF, Rubin B, Ondetti MA. Development of specific inhibitors of angiotensin I converting enzyme (kininase II). Federation Proceedings. 38: 2778-82. PMID 228989  0.77
1978 Cushman DW, Cheung HS, Sabo EF, Ondetti MA. Design of new antihypertensive drugs: potent and specific inhibitors of angiotensin-converting enzyme. Progress in Cardiovascular Diseases. 21: 176-82. PMID 214817 DOI: 10.1016/0033-0620(78)90023-3  0.788
1978 Ondetti MA, Cushman DW. Chapter 9. Inhibitors of the Renin-Angiotensin System Annual Reports in Medicinal Chemistry. 13: 82-91. DOI: 10.1016/S0065-7743(08)60612-0  0.742
1978 Cushman DW, Ondetti MA, Cheung HS. Substrate and inhibitor binding to angiotensin-converting enzyme (ACE): role of the C-terminal dipeptide sequence Federation Proceedings. 37: No. 2340.  0.752
1977 Cushman DW, Cheung HS, Sabo EF, Ondetti MA. Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids. Biochemistry. 16: 5484-91. PMID 200262 DOI: 10.1021/Bi00644A014  0.765
1977 Ondetti MA, Rubin B, Cushman DW. Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active antihypertensive agents. Science (New York, N.Y.). 196: 441-4. PMID 191908 DOI: 10.1126/Science.191908  0.776
1977 Cushman DW, Cheung HS, Ondetti MA. Design of active site-specific inhibitors of angiotensin-converting enzyme (ACE) Federation Proceedings. 36: No. 4088.  0.767
1973 Cushman DW, Pluscec J, Williams NJ, Weaver ER, Sabo EF, Kocy O, Cheung HS, Ondetti MA. Inhibition of angiotensin-coverting enzyme by analogs of peptides from Bothrops jararaca venom. Experientia. 29: 1032-5. PMID 4354751 DOI: 10.1007/Bf01930447  0.719
1972 Ondetti MA, Pluscec J, Sabo EF, Williams NJ, Weaver ER, Kocy O. Peptidic inhibitors of the angiotensin-converting enzyme. Medicina. 32: Suppl 1:9-14. PMID 4342069  0.501
1971 Ondetti MA, Williams NJ, Sabo EF, Pluscec J, Weaver ER, Kocy O. Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure, and synthesis. Biochemistry. 10: 4033-9. PMID 4334402 DOI: 10.1021/Bi00798A004  0.571
1963 Bodanszky M, Sheehan JT, Ondetti MA, Lande S. Glycine analogs of bradykinin Journal of the American Chemical Society. 85: 991-997. DOI: 10.1021/Ja00890A036  0.362
1962 Gros EG, Ondetti MA, Sproviero JO, Deulofeu V, Deferrari JO. Reaction of ammonia with some acetylated and benzoylated monosaccharides. VII. Migration of different benzoyl groups in the ammonolysis of penta-O-benzoyl-D-glucoses Journal of Organic Chemistry. 27: 924-929. DOI: 10.1021/Jo01050A057  0.469
1961 Ondetti MA, Deulofeu V. The structure of olivacine and u-alkaloid C (Guatambuine) Tetrahedron. 15: 160-166. DOI: 10.1016/0040-4020(61)80020-3  0.479
1960 Ondetti MA, Deulofeu V. Alkaloids from aspidosperma australe müll. Argov. (note II). The structure of olivacine and U-alkaloid C (guatambuine) Tetrahedron Letters. 1: 18-22.  0.514
1959 Deferrari JO, Ondetti MA, Deulofeu V. Reaction of ammonia with some acetylated and benzoylated monosaccharides. VI. Derivatives of L-arabinose, D-xylose, and D-ribose Journal of Organic Chemistry. 24: 183-186. DOI: 10.1021/Jo01084A009  0.483
1959 Ondetti MA, Deulofeu V. Alkaloids from aspidosperma australe müll. argov. relationship of olivacine to u-alkaloid C Tetrahedron Letters. 1: 1-4.  0.473
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