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Erica O. Saphire, Ph.D. - Publications

Affiliations: 
2000 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Structural biology, immunology, X-ray crystallography
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150 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Saphire E, Salie ZL, Ke Z, Halfmann P, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel S, Hariharan C, Norris M, Yu X, Chennareddy C, Xiong X, Heinrich M, et al. Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the virion membrane. Research Square. PMID 38196595 DOI: 10.21203/rs.3.rs-3722563/v1  0.387
2023 Olmedillas E, Rajamanickam RR, Avalos RD, Sosa FA, Zandonatti MA, Harkins SS, Shresta S, Hastie KM, Saphire EO. Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation. Biorxiv : the Preprint Server For Biology. PMID 38168261 DOI: 10.1101/2023.12.14.571764  0.355
2023 Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO. The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus. Cell Reports. 42: 113366. PMID 37938974 DOI: 10.1016/j.celrep.2023.113366  0.429
2023 Streblow DN, Hirsch AJ, Stanton JJ, Lewis AD, Colgin L, Hessell AJ, Kreklywich CN, Smith JL, Sutton WF, Chauvin D, Woo J, Bimber BN, LeBlanc CN, Acharya SN, O'Roak BJ, ... ... Saphire EO, et al. Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology. Nature Communications. 14: 7062. PMID 37923717 DOI: 10.1038/s41467-023-42440-x  0.356
2023 Ronk AJ, Lloyd NM, Zhang M, Atyeo C, Perrett HR, Mire CE, Hastie KM, Sanders RW, Brouwer PJM, Saphire EO, Ward AB, Ksiazek TG, Alvarez Moreno JC, Thaker HM, Alter G, et al. A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection. Nature Communications. 14: 5603. PMID 37699929 DOI: 10.1038/s41467-023-41376-6  0.395
2023 Fang J, Castillon G, Phan S, McArdle S, Hariharan C, Adams A, Ellisman MH, Deniz AA, Saphire EO. Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories. Nature Communications. 14: 4159. PMID 37443171 DOI: 10.1038/s41467-023-39821-7  0.305
2023 Kaplonek P, Cizmeci D, Kwatra G, Izu A, Lee JS, Bertera HL, Fischinger S, Mann C, Amanat F, Wang W, Koen AL, Fairlie L, Cutland CL, Ahmed K, Dheda K, ... ... Saphire EO, et al. ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19. Nature Immunology. PMID 37322179 DOI: 10.1038/s41590-023-01513-1  0.366
2023 Hastie KM, Yu X, Ana-Sosa-Batiz F, Zyla DS, Harkins SS, Hariharan C, Wasserman H, Zandonatti MA, Miller R, Maule E, Kim K, Valentine KM, Shresta S, Saphire EO. Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence. Cell Reports. 42: 112421. PMID 37083327 DOI: 10.1016/j.celrep.2023.112421  0.361
2023 Gunn BM, McNamara RP, Wood L, Taylor S, Devadhasan A, Guo W, Das J, Nilsson A, Shurtleff A, Dubey S, Eichberg M, Suscovich TJ, Saphire EO, Lauffenburger D, Coller BA, et al. Antibodies against the Ebola virus soluble glycoprotein are associated with long-term vaccine-mediated protection of non-human primates. Cell Reports. 42: 112402. PMID 37061918 DOI: 10.1016/j.celrep.2023.112402  0.323
2023 Chen EC, Gilchuk P, Zost SJ, Ilinykh PA, Binshtein E, Huang K, Myers L, Bonissone S, Day S, Kona CR, Trivette A, Reidy JX, Sutton RE, Gainza C, Diaz S, ... ... Saphire EO, et al. Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes. Cell Reports. 42: 112370. PMID 37029928 DOI: 10.1016/j.celrep.2023.112370  0.415
2023 Moon-Walker A, Zhang Z, Zyla DS, Buck TK, Li H, Diaz Avalos R, Schendel SL, Hastie KM, Crotty S, Saphire EO. Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus. Cell Chemical Biology. PMID 36990092 DOI: 10.1016/j.chembiol.2023.03.005  0.417
2023 Mahita J, Ha B, Gambiez A, Schendel SL, Li H, Hastie KM, Dennison SM, Li K, Kuzmina N, Periasamy S, Bukreyev A, Munt JE, Osei-Twum M, Atyeo C, Overton JA, ... ... Saphire EO, et al. Coronavirus Immunotherapeutic Consortium Database. Database : the Journal of Biological Databases and Curation. 2023. PMID 36763096 DOI: 10.1093/database/baac112  0.325
2023 Rayaprolu V, Fulton BO, Rafique A, Arturo E, Williams D, Hariharan C, Callaway H, Parvate A, Schendel SL, Parekh D, Hui S, Shaffer K, Pascal KE, Wloga E, Giordano S, ... ... Saphire EO, et al. Structure of the Inmazeb cocktail and resistance to Ebola virus escape. Cell Host & Microbe. PMID 36708708 DOI: 10.1016/j.chom.2023.01.002  0.432
2023 Callaway HM, Hastie KM, Schendel SL, Li H, Yu X, Shek J, Buck T, Hui S, Bedinger D, Troup C, Dennison SM, Li K, Alpert MD, Bailey CC, Benzeno S, ... ... Saphire EO, et al. Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium. Cell Reports. 42: 112014. PMID 36681898 DOI: 10.1016/j.celrep.2023.112014  0.341
2022 Cable J, Saphire EO, Hayday AC, Wiltshire TD, Mousa JJ, Humphreys DP, Breij ECW, Bruhns P, Broketa M, Furuya G, Hauser BM, Mahévas M, Carfi A, Cantaert T, Kwong PD, et al. Antibodies as drugs-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 36382536 DOI: 10.1111/nyas.14915  0.303
2022 Worwa G, Cooper TK, Yeh S, Shantha JG, Hischak AMW, Klim SE, Byrum R, Kurtz JR, Anthony SM, Aiosa NM, Ragland D, Lee JH, Claire MS, Davis C, Ahmed R, ... ... Saphire EO, et al. Persistent intraocular Ebola virus RNA is associated with severe uveitis in a convalescent rhesus monkey. Communications Biology. 5: 1204. PMID 36352100 DOI: 10.1038/s42003-022-04158-2  0.309
2022 Li H, Buck T, Zandonatti M, Yin J, Moon-Walker A, Fang J, Koval A, Heinrich ML, Rowland MM, Diaz Avalos R, Schendel SL, Parekh D, Zyla D, Enriquez A, Harkins S, ... ... Saphire EO, et al. A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus. Science Translational Medicine. 14: eabq0991. PMID 36288283 DOI: 10.1126/scitranslmed.abq0991  0.414
2022 Chang MR, Tomasovic L, Kuzmina NA, Ronk AJ, Byrne PO, Johnson R, Storm N, Olmedillas E, Hou YJ, Schäfer A, Leist SR, Tse LV, Ke H, Coherd C, Nguyen K, ... ... Saphire EO, et al. IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern. Nature Communications. 13: 5814. PMID 36192374 DOI: 10.1038/s41467-022-33030-4  0.37
2022 Peng W, Rayaprolu V, Parvate AD, Pronker MF, Hui S, Parekh D, Shaffer K, Yu X, Saphire EO, Snijder J. Glycan shield of the ebolavirus envelope glycoprotein GP. Communications Biology. 5: 785. PMID 35927436 DOI: 10.1038/s42003-022-03767-1  0.312
2022 Buck TK, Enriquez AS, Schendel SL, Zandonatti MA, Harkins SS, Li H, Moon-Walker A, Robinson JE, Branco LM, Garry RF, Saphire EO, Hastie KM. Neutralizing Antibodies against Lassa Virus Lineage I. Mbio. e0127822. PMID 35730904 DOI: 10.1128/mbio.01278-22  0.426
2022 Callaway HM, Zyla D, Larrous F, de Melo GD, Hastie KM, Avalos RD, Agarwal A, Corti D, Bourhy H, Saphire EO. Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science Advances. 8: eabp9151. PMID 35714192 DOI: 10.1126/sciadv.abp9151  0.381
2022 Enriquez AS, Buck TK, Li H, Norris MJ, Moon-Walker A, Zandonatti MA, Harkins SS, Robinson JE, Branco LM, Garry RF, Saphire EO, Hastie KM. Delineating the mechanism of anti-Lassa virus GPC-A neutralizing antibodies. Cell Reports. 39: 110841. PMID 35613585 DOI: 10.1016/j.celrep.2022.110841  0.48
2022 Yu X, Saphire EO. Development and Structural Analysis of Antibody Therapeutics for Filoviruses. Pathogens (Basel, Switzerland). 11. PMID 35335698 DOI: 10.3390/pathogens11030374  0.435
2022 Milligan JC, Davis CW, Yu X, Ilinykh PA, Huang K, Halfmann PJ, Cross RW, Borisevich V, Agans KN, Geisbert JB, Chennareddy C, Goff AJ, Piper AE, Hui S, Shaffer KCL, ... ... Saphire EO, et al. Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses. Cell. 185: 995-1007.e18. PMID 35303429 DOI: 10.1016/j.cell.2022.02.023  0.451
2022 Kaplonek P, Fischinger S, Cizmeci D, Bartsch YC, Kang J, Burke JS, Shin SA, Dayal D, Martin P, Mann C, Amanat F, Julg B, Nilles EJ, Musk ER, Menon AS, ... ... Saphire EO, et al. mRNA-1273 vaccine-induced antibodies maintain Fc effector functions across SARS-CoV-2 variants of concern. Immunity. PMID 35090580 DOI: 10.1016/j.immuni.2022.01.001  0.308
2022 Yuan TZ, Garg P, Wang L, Willis JR, Kwan E, Hernandez AGL, Tuscano E, Sever EN, Keane E, Soto C, Mucker EM, Fouch ME, Davidson E, Doranz BJ, Kailasan S, ... ... Saphire EO, et al. Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries. Mabs. 14: 2002236. PMID 34967699 DOI: 10.1080/19420862.2021.2002236  0.385
2021 Gilchuk P, Guthals A, Bonissone SR, Shaw JB, Ilinykh PA, Huang K, Bombardi RG, Liang J, Grinyo A, Davidson E, Chen EC, Gunn BM, Alter G, Saphire EO, Doranz BJ, et al. Proteo-Genomic Analysis Identifies Two Major Sites of Vulnerability on Ebolavirus Glycoprotein for Neutralizing Antibodies in Convalescent Human Plasma. Frontiers in Immunology. 12: 706757. PMID 34335620 DOI: 10.3389/fimmu.2021.706757  0.408
2021 Hassan AO, Shrihari S, Gorman MJ, Ying B, Yaun D, Raju S, Chen RE, Dmitriev IP, Kashentseva E, Adams LJ, Mann C, Davis-Gardner ME, Suthar MS, Shi PY, Saphire EO, et al. An intranasal vaccine durably protects against SARS-CoV-2 variants in mice. Cell Reports. 109452. PMID 34289385 DOI: 10.1016/j.celrep.2021.109452  0.529
2021 Landeras-Bueno S, Wasserman H, Oliveira G, VanAernum ZL, Busch F, Salie ZL, Wysocki VH, Andersen K, Saphire EO. Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form. Cell Reports. 35: 108986. PMID 33852858 DOI: 10.1016/j.celrep.2021.108986  0.34
2021 Gunn BM, Lu R, Slein MD, Ilinykh PA, Huang K, Atyeo C, Schendel SL, Kim J, Cain C, Roy V, Suscovich TJ, Takada A, Halfmann PJ, Kawaoka Y, Pauthner MG, ... ... Saphire EO, et al. A Fc engineering approach to define functional humoral correlates of immunity against Ebola virus. Immunity. 54: 815-828.e5. PMID 33852832 DOI: 10.1016/j.immuni.2021.03.009  0.388
2021 Wang Y, Howell KA, Brannan J, Agans KN, Turner HL, Wirchnianski AS, Kailasan S, Fusco M, Galkin A, Chiang CI, Zhao X, Saphire EO, Chandran K, Ward AB, Dye JM, et al. Prominent Neutralizing Antibody Response Targeting the Glycoprotein Subunit Interface Elicited by Immunization. Journal of Virology. PMID 33536172 DOI: 10.1128/JVI.01907-20  0.373
2020 Heinrich ML, Boisen ML, Nelson DKS, Bush DJ, Cross RW, Koval AP, Hoffmann AR, Beddingfield BJ, Hastie KM, Rowland MM, Aimukanova I, Koval S, Lathigra R, Borisevich V, Momoh M, ... ... Saphire EO, et al. Antibodies from Sierra Leonean and Nigerian Lassa fever survivors cross-react with recombinant proteins representing Lassa viruses of divergent lineages. Scientific Reports. 10: 16030. PMID 32994446 DOI: 10.1038/s41598-020-72539-w  0.333
2020 Mercer J, Lee JE, Saphire EO, Freeman SA. SnapShot: Enveloped Virus Entry. Cell. 182: 786-786.e1. PMID 32763187 DOI: 10.1016/J.Cell.2020.06.033  0.371
2020 Korber B, Fischer WM, Gnanakaran S, Yoon H, Theiler J, Abfalterer W, Hengartner N, Giorgi EE, Bhattacharya T, Foley B, Hastie KM, Parker MD, Partridge DG, Evans CM, Freeman TM, ... ... Saphire EO, et al. Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus. Cell. PMID 32697968 DOI: 10.1016/J.Cell.2020.06.043  0.355
2020 Wang YT, Landeras-Bueno S, Hsieh LE, Terada Y, Kim K, Ley K, Shresta S, Saphire EO, Regla-Nava JA. Spiking Pandemic Potential: Structural and Immunological Aspects of SARS-CoV-2. Trends in Microbiology. PMID 32507543 DOI: 10.1016/J.Tim.2020.05.012  0.335
2020 Ilinykh PA, Huang K, Santos RI, Gilchuk P, Gunn BM, Karim MM, Liang J, Fouch ME, Davidson E, Parekh DV, Kimble JB, Pietzsch CA, Meyer M, Kuzmina NA, Zeitlin L, ... Saphire EO, et al. Non-neutralizing Antibodies from a Marburg Infection Survivor Mediate Protection by Fc-Effector Functions and by Enhancing Efficacy of Other Antibodies. Cell Host & Microbe. PMID 32320678 DOI: 10.1016/J.Chom.2020.03.025  0.555
2020 Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, ... ... Saphire EO, et al. Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization. Immunity. PMID 32023489 DOI: 10.1016/J.Immuni.2020.01.001  0.584
2020 Lin AE, Diehl WE, Cai Y, Finch CL, Akusobi C, Kirchdoerfer RN, Bollinger L, Schaffner SF, Brown EA, Saphire EO, Andersen KG, Kuhn JH, Luban J, Sabeti PC. Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111. Viruses. 12. PMID 31952352 DOI: 10.3390/V12010105  0.351
2020 Saphire E, Li H, Hastie K, Branco L, Garry R, Harkins S, Enriquez A, Buck T, Zandonatti M. From Kenema to Our Krios: Medical Defense Against Lassa Virus and Emerging Infectious Disease Microscopy and Microanalysis. 1-1. DOI: 10.1017/S1431927620015111  0.344
2019 Saphire EO. A glimpse into immune responses evolving against Ebola virus. Nature Medicine. PMID 31591604 DOI: 10.1038/S41591-019-0607-Z  0.461
2019 Parvate A, Williams EP, Taylor MK, Chu YK, Lanman J, Saphire EO, Jonsson CB. Diverse Morphology and Structural Features of Old and New World Hantaviruses. Viruses. 11. PMID 31527500 DOI: 10.3390/V11090862  0.307
2019 Hastie KM, Cross RW, Harkins SS, Zandonatti MA, Koval AP, Heinrich ML, Rowland MM, Robinson JE, Geisbert TW, Garry RF, Branco LM, Saphire EO. Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization. Cell. 178: 1004-1015.e14. PMID 31398326 DOI: 10.1016/J.Cell.2019.07.020  0.536
2019 Landeras-Bueno S, Oda SI, Norris MJ, Li Salie Z, Guenaga J, Wyatt RT, Saphire EO. Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment. Mbio. 10. PMID 31337716 DOI: 10.1128/Mbio.00734-19  0.442
2019 Davis CW, Jackson KJL, McElroy AK, Halfmann P, Huang J, Chennareddy C, Piper AE, Leung Y, Albariño CG, Crozier I, Ellebedy AH, Sidney J, Sette A, Yu T, Nielsen SCA, ... ... Saphire EO, et al. Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection. Cell. PMID 31104840 DOI: 10.1016/J.Cell.2019.04.036  0.443
2019 Kirchdoerfer RN, Saphire EO, Ward AB. Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex. Acta Crystallographica. Section F, Structural Biology Communications. 75: 340-347. PMID 31045563 DOI: 10.1107/S2053230X19004424  0.424
2019 King LB, West BR, Moyer CL, Gilchuk P, Flyak A, Ilinykh PA, Bombardi R, Hui S, Huang K, Bukreyev A, Crowe JE, Saphire EO. Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. Nature Communications. 10: 1788. PMID 30996276 DOI: 10.1038/S41467-019-09732-7  0.588
2019 West BR, Wec AZ, Moyer CL, Fusco ML, Ilinykh PA, Huang K, Wirchnianski AS, James RM, Herbert AS, Hui S, Goodwin E, Howell KA, Kailasan S, Aman MJ, Walker LM, ... ... Saphire EO, et al. Structural basis of broad ebolavirus neutralization by a human survivor antibody. Nature Structural & Molecular Biology. PMID 30833785 DOI: 10.1038/S41594-019-0191-4  0.57
2019 Bruhn JF, Hotard AL, Spiropoulou CF, Lo MK, Saphire EO. A Conserved Basic Patch and Central Kink in the Nipah Virus Phosphoprotein Multimerization Domain Are Essential for Polymerase Function. Structure (London, England : 1993). PMID 30799076 DOI: 10.1016/J.Str.2019.01.012  0.388
2019 Williamson L, Flyak AI, Kose N, Bombardi R, Branchizio A, Reddy S, Davidson E, Doranz B, Fusco ML, Saphire EO, Halfmann PJ, Kawaoka Y, Piper AE, Glass PJ, Crowe JE. Early human B cell response to Ebola virus in four U.S. survivors of infection. Journal of Virology. PMID 30728263 DOI: 10.1128/Jvi.01439-18  0.498
2018 Patel A, Park DH, Davis CW, Smith TRF, Leung A, Tierney K, Bryan A, Davidson E, Yu X, Racine T, Reed C, Gorman ME, Wise MC, Elliott STC, Esquivel R, ... ... Saphire EO, et al. In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model. Cell Reports. 25: 1982-1993.e4. PMID 30428362 DOI: 10.1016/J.Celrep.2018.10.062  0.463
2018 Saphire EO, Schendel SL, Gunn BM, Milligan JC, Alter G. Antibody-mediated protection against Ebola virus. Nature Immunology. 19: 1169-1178. PMID 30333617 DOI: 10.1038/S41590-018-0233-9  0.513
2018 West BR, Moyer CL, King LB, Fusco ML, Milligan JC, Hui S, Saphire EO. Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope. Mbio. 9. PMID 30206174 DOI: 10.1128/Mbio.01674-18  0.596
2018 Milligan JC, Parekh DV, Fuller KM, Igarashi M, Takada A, Saphire EO. Structural Characterization of Pan-ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein. The Journal of Infectious Diseases. PMID 30203042 DOI: 10.1093/Infdis/Jiy532  0.492
2018 Meyer M, Yoshida A, Ramanathan P, Saphire EO, Collins PL, Crowe JE, Samal S, Bukreyev A. Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors. Cell Reports. 24: 1816-1829. PMID 30110638 DOI: 10.1016/J.Celrep.2018.07.044  0.438
2018 Saphire EO, Schendel SL, Fusco ML, Gangavarapu K, Gunn BM, Wec AZ, Halfmann PJ, Brannan JM, Herbert AS, Qiu X, Wagh K, He S, Giorgi EE, Theiler J, Pommert KBJ, et al. Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection. Cell. 174: 938-952.e13. PMID 30096313 DOI: 10.1016/J.Cell.2018.07.033  0.555
2018 Gunn BM, Yu WH, Karim MM, Brannan JM, Herbert AS, Wec AZ, Halfmann PJ, Fusco ML, Schendel SL, Gangavarapu K, Krause T, Qiu X, He S, Das J, Suscovich TJ, ... ... Saphire EO, et al. A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus. Cell Host & Microbe. 24: 221-233.e5. PMID 30092199 DOI: 10.1016/J.Chom.2018.07.009  0.503
2018 Gilchuk P, Kuzmina N, Ilinykh PA, Huang K, Gunn BM, Bryan A, Davidson E, Doranz BJ, Turner HL, Fusco ML, Bramble MS, Hoff NA, Binshtein E, Kose N, Flyak AI, ... ... Saphire EO, et al. Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein. Immunity. PMID 30029854 DOI: 10.1016/J.Immuni.2018.06.018  0.519
2018 King LB, West BR, Schendel SL, Saphire EO. The structural basis for filovirus neutralization by monoclonal antibodies. Current Opinion in Immunology. 53: 196-202. PMID 29940415 DOI: 10.1016/J.Coi.2018.05.001  0.532
2018 Hastie KM, Saphire EO. Lassa virus glycoprotein: stopping a moving target. Current Opinion in Virology. PMID 29843991 DOI: 10.1016/J.Coviro.2018.05.002  0.494
2018 Flyak AI, Kuzmina N, Murin CD, Bryan C, Davidson E, Gilchuk P, Gulka CP, Ilinykh PA, Shen X, Huang K, Ramanathan P, Turner H, Fusco ML, Lampley R, Kose N, ... ... Saphire EO, et al. Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region. Nature Microbiology. PMID 29736037 DOI: 10.1038/S41564-018-0157-Z  0.535
2018 Boisen ML, Hartnett JN, Shaffer JG, Goba A, Momoh M, Sandi JD, Fullah M, Nelson DKS, Bush DJ, Rowland MM, Heinrich ML, Koval AP, Cross RW, Barnes KG, Lachenauer AE, ... ... Saphire EO, et al. Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever. Scientific Reports. 8: 5939. PMID 29651117 DOI: 10.1038/S41598-018-24246-W  0.415
2018 Del Vecchio K, Frick CT, Gc JB, Oda SI, Gerstman BS, Saphire EO, Chapagain PP, Stahelin RV. A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine. The Journal of Biological Chemistry. PMID 29348171 DOI: 10.1074/Jbc.M117.816280  0.418
2018 King LB, Fusco ML, Flyak AI, Ilinykh PA, Huang K, Gunn B, Kirchdoerfer RN, Hastie KM, Sangha AK, Meiler J, Alter G, Bukreyev A, Crowe JE, Saphire EO. The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host & Microbe. 23: 101-109.e4. PMID 29324225 DOI: 10.1016/J.Chom.2017.12.003  0.528
2017 Sangha AK, Dong J, Williamson L, Hashiguchi T, Saphire EO, Crowe JE, Meiler J. Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein. Structure (London, England : 1993). PMID 29153506 DOI: 10.1016/J.Str.2017.10.005  0.448
2017 Kirchdoerfer RN, Wasserman H, Amarasinghe GK, Saphire EO. Filovirus Structural Biology: The Molecules in the Machine. Current Topics in Microbiology and Immunology. PMID 28795188 DOI: 10.1007/82_2017_16  0.344
2017 Hastie KM, Zandonatti MA, Kleinfelter LM, Heinrich ML, Rowland MM, Chandran K, Branco LM, Robinson JE, Garry RF, Saphire EO. Structural basis for antibody-mediated neutralization of Lassa virus. Science (New York, N.Y.). 356: 923-928. PMID 28572385 DOI: 10.1126/Science.Aam7260  0.572
2017 Saphire EO, Hastie K, Zandonatti M, Branco L, Robinson J, Garry R. Crystal structure of the Lassa virus surface glycoprotein Acta Crystallographica Section a Foundations and Advances. 73: a12-a12. DOI: 10.1107/S0108767317099871  0.414
2016 Bruhn JF, Kirchdoerfer RN, Urata SM, Li S, Tickle IJ, Bricogne G, Saphire EO. Crystal Structure of the Marburg Virus VP35 Oligomerization Domain. Journal of Virology. PMID 27847355 DOI: 10.1128/Jvi.01085-16  0.449
2016 Kirchdoerfer RN, Moyer CL, Abelson DM, Saphire EO. The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis. Plos Pathogens. 12: e1005937. PMID 27755595 DOI: 10.1371/Journal.Ppat.1005937  0.392
2016 Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, et al. A "Trojan horse" bispecific antibody strategy for broad protection against ebolaviruses. Science (New York, N.Y.). PMID 27608667 DOI: 10.1126/Science.Aag3267  0.519
2016 Cross RW, Boisen ML, Millett MM, Nelson DS, Oottamasathien D, Hartnett JN, Jones AB, Goba A, Momoh M, Fullah M, Bornholdt ZA, Fusco ML, Abelson DM, Oda S, Brown BL, ... ... Saphire EO, et al. Analytical Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection. The Journal of Infectious Diseases. PMID 27587634 DOI: 10.1093/Infdis/Jiw293  0.412
2016 Pallesen J, Murin CD, de Val N, Cottrell CA, Hastie KM, Turner HL, Fusco ML, Flyak AI, Zeitlin L, Crowe JE, Andersen KG, Saphire EO, Ward AB. Structures of Ebola virus GP and sGP in complex with therapeutic antibodies. Nature Microbiology. 1: 16128. PMID 27562261 DOI: 10.1038/Nmicrobiol.2016.128  0.535
2016 Wasserman H, Saphire EO. More than Meets the Eye: Hidden Structures in the Proteome. Annual Review of Virology. PMID 27482901 DOI: 10.1146/Annurev-Virology-100114-054923  0.348
2016 Goba A, Khan SH, Fonnie M, Fullah M, Moigboi A, Kovoma A, Sinnah V, Yoko N, Rogers H, Safai S, Momoh M, Koroma V, Kamara FK, Konowu E, Yillah M, ... ... Saphire EO, et al. An Outbreak of Ebola Virus Disease in the Lassa Fever Zone. The Journal of Infectious Diseases. PMID 27402779 DOI: 10.1093/Infdis/Jiw239  0.372
2016 Saphire EO, Aman MJ. Feverish Quest for Ebola Immunotherapy: Straight or Cocktail? Trends in Microbiology. PMID 27338027 DOI: 10.1016/J.Tim.2016.05.008  0.404
2016 Robinson JE, Hastie KM, Cross RW, Yenni RE, Elliott DH, Rouelle JA, Kannadka CB, Smira AA, Garry CE, Bradley BT, Yu H, Shaffer JG, Boisen ML, Hartnett JN, Zandonatti MA, ... ... Saphire EO, et al. Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits. Nature Communications. 7: 11544. PMID 27161536 DOI: 10.1038/Ncomms11544  0.554
2016 Howell KA, Qiu X, Brannan JM, Bryan C, Davidson E, Holtsberg FW, Wec AZ, Shulenin S, Biggins JE, Douglas R, Enterlein SG, Turner HL, Pallesen J, Murin CD, He S, ... ... Saphire EO, et al. Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site. Cell Reports. PMID 27160900 DOI: 10.1016/J.Celrep.2016.04.026  0.513
2016 Hastie KM, Igonet S, Sullivan BM, Legrand P, Zandonatti MA, Robinson JE, Garry RF, Rey FA, Oldstone MB, Saphire EO. Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV. Nature Structural & Molecular Biology. PMID 27111888 DOI: 10.1038/Nsmb.3210  0.476
2016 Qiu X, Audet J, Lv M, He S, Wong G, Wei H, Luo L, Fernando L, Kroeker A, Bovendo HF, Bello A, Li F, Ye P, Jacobs M, Ippolito G, ... Saphire EO, et al. Two-mAb cocktail protects macaques against the Makona variant of Ebola virus. Science Translational Medicine. 8: 329ra33. PMID 26962157 DOI: 10.1126/Scitranslmed.Aad9875  0.507
2016 Hastie KM, Zandonatti M, Liu T, Li S, Woods VL, Saphire EO. Crystal structure of the oligomeric form of the Lassa virus matrix protein Z. Journal of Virology. PMID 26912609 DOI: 10.1128/Jvi.02896-15  0.374
2016 Bornholdt ZA, Turner HL, Murin CD, Li W, Sok D, Souders CA, Piper AE, Goff A, Shamblin JD, Wollen SE, Sprague TR, Fusco ML, Pommert KB, Cavacini LA, Smith HL, ... ... Saphire EO, et al. Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak. Science (New York, N.Y.). PMID 26912366 DOI: 10.1126/Science.Aad5788  0.56
2016 Flyak AI, Shen X, Murin CD, Turner HL, David JA, Fusco ML, Lampley R, Kose N, Ilinykh PA, Kuzmina N, Branchizio A, King H, Brown L, Bryan C, Davidson E, ... ... Saphire EO, et al. Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection. Cell. PMID 26806128 DOI: 10.1016/J.Cell.2015.12.022  0.554
2016 Dye J, Chandran K, Kobinger G, Kawaoka Y, Zeitlin L, Ward A, Nykiforuk C, Aman J, Lai J, Saphire E. E-105 Antibodies against ebola virus Jaids Journal of Acquired Immune Deficiency Syndromes. 71: 58. DOI: 10.1097/01.Qai.0000479621.47644.67  0.485
2015 Bornholdt ZA, Ndungo E, Fusco ML, Bale S, Flyak AI, Crowe JE, Chandran K, Saphire EO. Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies. Mbio. 7. PMID 26908579 DOI: 10.1128/Mbio.02154-15  0.535
2015 Oda SI, Noda T, Wijesinghe KJ, Halfmann P, Bornholdt ZA, Abelson DM, Armbrust T, Stahelin RV, Kawaoka Y, Saphire EO. Crystal structure of Marburg virus VP40: matrix assembly and immunosuppression. Journal of Virology. PMID 26656687 DOI: 10.1128/Jvi.01597-15  0.465
2015 Kielian M, Saphire EO. Potent Antibody Protection against an Emerging Alphavirus Threat. Cell. 163: 1053-4. PMID 26590413 DOI: 10.1016/J.Cell.2015.11.006  0.526
2015 Holtsberg FW, Shulenin S, Vu H, Howell KA, Patel SJ, Gunn B, Karim M, Lai JR, Frei JC, Nyakatura EK, Zeitlin L, Douglas R, Fusco ML, Froude JW, Saphire EO, et al. Pan-ebolavirus and pan-filovirus mouse monoclonal antibodies: protection against Ebola and Sudan viruses. Journal of Virology. PMID 26468533 DOI: 10.1128/Jvi.02171-15  0.538
2015 Fusco ML, Hashiguchi T, Cassan R, Biggins JE, Murin CD, Warfield KL, Li S, Holtsberg FW, Shulenin S, Vu H, Olinger GG, Kim DH, Whaley KJ, Zeitlin L, Ward AB, ... ... Saphire EO, et al. Correction: Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs. Plos Pathogens. 11: e1005212. PMID 26452225 DOI: 10.1371/Journal.Ppat.1005212  0.339
2015 Burton DR, Saphire EO. Swift antibodies to counter emerging viruses. Proceedings of the National Academy of Sciences of the United States of America. 112: 10082-3. PMID 26261336 DOI: 10.1073/Pnas.1513050112  0.465
2015 Boisen ML, Oottamasathien D, Jones AB, Millett MM, Nelson DS, Bornholdt ZA, Fusco ML, Abelson DM, Oda S, Hartnett JN, Rowland MM, Heinrich ML, Akdag M, Goba A, Momoh M, ... ... Saphire EO, et al. Development of Prototype Filovirus Recombinant Antigen Immunoassays. The Journal of Infectious Diseases. 212: S359-67. PMID 26232440 DOI: 10.1093/Infdis/Jiv353  0.321
2015 Kirchdoerfer RN, Abelson DM, Li S, Wood MR, Saphire EO. Assembly of the Ebola Virus Nucleoprotein from a Chaperoned VP35 Complex. Cell Reports. PMID 26119732 DOI: 10.1016/J.Celrep.2015.06.003  0.387
2015 Fusco ML, Hashiguchi T, Cassan R, Biggins JE, Murin CD, Warfield KL, Li S, Holtsberg FW, Shulenin S, Vu H, Olinger GG, Kim DH, Whaley KJ, Zeitlin L, Ward AB, ... ... Saphire EO, et al. Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs. Plos Pathogens. 11: e1005016. PMID 26115029 DOI: 10.1371/Journal.Ppat.1005016  0.569
2015 Saphire EO. New Advances in the Effort against Ebola. Cell Host & Microbe. 17: 545-7. PMID 25974296 DOI: 10.1016/J.Chom.2015.04.015  0.313
2015 Clifton MC, Bruhn JF, Atkins K, Webb TL, Baydo RO, Raymond A, Lorimer DD, Edwards TE, Myler PJ, Saphire EO. High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus. The Journal of Infectious Diseases. 212: S167-71. PMID 25957961 DOI: 10.1093/Infdis/Jiv090  0.419
2015 Hashiguchi T, Fusco ML, Bornholdt ZA, Lee JE, Flyak AI, Matsuoka R, Kohda D, Yanagi Y, Hammel M, Crowe JE, Saphire EO. Structural basis for Marburg virus neutralization by a cross-reactive human antibody. Cell. 160: 904-12. PMID 25723165 DOI: 10.1016/J.Cell.2015.01.041  0.584
2015 Flyak AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, Hashiguchi T, Bornholdt ZA, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Ward AB, Saphire EO, Bukreyev A, et al. Mechanism of human antibody-mediated neutralization of Marburg virus. Cell. 160: 893-903. PMID 25723164 DOI: 10.1016/J.Cell.2015.01.031  0.555
2015 Boisen ML, Schieffelin JS, Goba A, Oottamasathien D, Jones AB, Shaffer JG, Hastie KM, Hartnett JN, Momoh M, Fullah M, Gabiki M, Safa S, Zandonatti M, Fusco M, Bornholdt Z, ... ... Saphire EO, et al. Multiple circulating infections can mimic the early stages of viral hemorrhagic fevers and possible human exposure to filoviruses in Sierra Leone prior to the 2014 outbreak. Viral Immunology. 28: 19-31. PMID 25531344 DOI: 10.1089/Vim.2014.0108  0.437
2014 Murin CD, Fusco ML, Bornholdt ZA, Qiu X, Olinger GG, Zeitlin L, Kobinger GP, Ward AB, Saphire EO. Structures of protective antibodies reveal sites of vulnerability on Ebola virus. Proceedings of the National Academy of Sciences of the United States of America. 111: 17182-7. PMID 25404321 DOI: 10.1073/Pnas.1414164111  0.53
2014 West BR, Hastie KM, Saphire EO. Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression. Acta Crystallographica. Section D, Biological Crystallography. 70: 1764-9. PMID 24914986 DOI: 10.1107/S1399004714007883  0.384
2014 Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO. Structure of the Reston ebolavirus VP30 C-terminal domain. Acta Crystallographica. Section F, Structural Biology Communications. 70: 457-60. PMID 24699737 DOI: 10.1107/S2053230X14003811  0.35
2014 Olal D, Dick A, Woods VL, Liu T, Li S, Devignot S, Weber F, Saphire EO, Daumke O. Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein. Nucleic Acids Research. 42: 6025-37. PMID 24688060 DOI: 10.1093/Nar/Gku229  0.357
2014 Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJ, van de Winkel JG, Wilson IA, Koster AJ, Taylor RP, Saphire EO, et al. Complement is activated by IgG hexamers assembled at the cell surface. Science (New York, N.Y.). 343: 1260-3. PMID 24626930 DOI: 10.1126/Science.1248943  0.538
2014 Zhang AP, Bornholdt ZA, Abelson DM, Saphire EO. Crystal structure of Marburg virus VP24. Journal of Virology. 88: 5859-63. PMID 24574400 DOI: 10.1128/Jvi.03565-13  0.469
2014 Kuhn JH, Bào Y, Bavari S, Becker S, Bradfute S, Brauburger K, Rodney Brister J, Bukreyev AA, Caì Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, ... ... Saphire EO, et al. Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA. Archives of Virology. 159: 1229-37. PMID 24190508 DOI: 10.1007/S00705-013-1877-2  0.421
2014 Bruhn JF, Barnett KC, Bibby J, Thomas JM, Keegan RM, Rigden DJ, Bornholdt ZA, Saphire EO. Crystal structure of the nipah virus phosphoprotein tetramerization domain. Journal of Virology. 88: 758-62. PMID 24155387 DOI: 10.1128/Jvi.02294-13  0.435
2014 Bornholdt Z, Noda T, Abelson D, Halfmann P, Wood M, Kawaoa Y, Saphire EO. 133 Structural basis for ebolavirus matrix assembly and budding; protein plasticity allows multiple functions Jaids Journal of Acquired Immune Deficiency Syndromes. 65: 55. DOI: 10.1097/01.Qai.0000446713.32982.25  0.431
2014 Saphire EO, Bornholdt ZA, Abelson DM, Halfmann P, Noda T, Wood M, Kawaoka Y. Structural Rearrangement of the Ebola Virus VP40 Protein Begets Multiple Functions in the Virus Life Cycle Biophysical Journal. 106: 637a. DOI: 10.1016/J.Bpj.2013.11.3524  0.456
2013 Saphire EO. An update on the use of antibodies against the filoviruses. Immunotherapy. 5: 1221-33. PMID 24188676 DOI: 10.2217/Imt.13.124  0.491
2013 Bornholdt ZA, Noda T, Abelson DM, Halfmann P, Wood MR, Kawaoka Y, Saphire EO. Structural rearrangement of ebola virus VP40 begets multiple functions in the virus life cycle. Cell. 154: 763-74. PMID 23953110 DOI: 10.1016/J.Cell.2013.07.015  0.453
2013 Bale S, Julien JP, Bornholdt ZA, Krois AS, Wilson IA, Saphire EO. Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism. Journal of Virology. 87: 10385-8. PMID 23824825 DOI: 10.1128/Jvi.01452-13  0.473
2013 Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR, Bukreyev AA, Caì Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, Formenty P, ... ... Saphire EO, et al. Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae. Archives of Virology. 158: 1425-32. PMID 23358612 DOI: 10.1007/S00705-012-1594-2  0.357
2013 Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR, Bukreyev AA, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Hensley LE, Honko AN, Jahrling PB, ... ... Saphire EO, et al. Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae. Archives of Virology. 158: 301-11. PMID 23001720 DOI: 10.1007/S00705-012-1454-0  0.367
2013 Zhang APP, Bornholdt ZA, Liu T, Abelson DM, Lee DE, Li S, Woods VL, Saphire EO. Correction: The Ebola Virus Interferon Antagonist VP24 Directly Binds STAT1 and Has a Novel, Pyramidal Fold Plos Pathogens. 9. DOI: 10.1371/Annotation/360Ddc68-0313-4Eae-Af24-043Cc040C52D  0.334
2013 Beurskens FJ, de Jong RN, Verploegen S, Voorhorst M, Strumane K, Lindorfer MA, Taylor RP, Saphire EO, Burton D, Schuurman J, Parren PW. Enhanced IgG Hexamerization Mediates Efficient C1q Docking and Complement-Dependent Cytotoxicity; Preclinical Proof Of Concept On Primary CLL and Burkitt Lymphoma Blood. 122: 375-375. DOI: 10.1182/Blood.V122.21.375.375  0.42
2012 Koellhoffer JF, Chen G, Sandesara RG, Bale S, Saphire EO, Chandran K, Sidhu SS, Lai JR. Two synthetic antibodies that recognize and neutralize distinct proteolytic forms of the ebola virus envelope glycoprotein. Chembiochem : a European Journal of Chemical Biology. 13: 2549-57. PMID 23111988 DOI: 10.1002/Cbic.201200493  0.546
2012 Zhang AP, Abelson DM, Bornholdt ZA, Liu T, Woods VL, Saphire EO. The ebolavirus VP24 interferon antagonist: know your enemy. Virulence. 3: 440-5. PMID 23076242 DOI: 10.4161/Viru.21302  0.401
2012 Bale S, Julien JP, Bornholdt ZA, Kimberlin CR, Halfmann P, Zandonatti MA, Kunert J, Kroon GJ, Kawaoka Y, MacRae IJ, Wilson IA, Saphire EO. Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism. Plos Pathogens. 8: e1002916. PMID 23028316 DOI: 10.1371/Journal.Ppat.1002916  0.553
2012 Hastie KM, King LB, Zandonatti MA, Saphire EO. Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease. Plos One. 7: e44211. PMID 22937163 DOI: 10.1371/Journal.Pone.0044211  0.411
2012 Bale S, Dias JM, Fusco ML, Hashiguchi T, Wong AC, Liu T, Keuhne AI, Li S, Woods VL, Chandran K, Dye JM, Saphire EO. Structural basis for differential neutralization of ebolaviruses. Viruses. 4: 447-70. PMID 22590681 DOI: 10.3390/V4040447  0.575
2012 Hastie KM, Bale S, Kimberlin CR, Saphire EO. Hiding the evidence: two strategies for innate immune evasion by hemorrhagic fever viruses. Current Opinion in Virology. 2: 151-6. PMID 22482712 DOI: 10.1016/J.Coviro.2012.01.003  0.404
2012 Zhang AP, Bornholdt ZA, Liu T, Abelson DM, Lee DE, Li S, Woods VL, Saphire EO. The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold. Plos Pathogens. 8: e1002550. PMID 22383882 DOI: 10.1371/Journal.Ppat.1002550  0.443
2012 Olal D, Kuehne AI, Bale S, Halfmann P, Hashiguchi T, Fusco ML, Lee JE, King LB, Kawaoka Y, Dye JM, Saphire EO. Structure of an antibody in complex with its mucin domain linear epitope that is protective against Ebola virus. Journal of Virology. 86: 2809-16. PMID 22171276 DOI: 10.1128/Jvi.05549-11  0.574
2012 Brecher M, Schornberg KL, Delos SE, Fusco ML, Saphire EO, White JM. Cathepsin cleavage potentiates the Ebola virus glycoprotein to undergo a subsequent fusion-relevant conformational change. Journal of Virology. 86: 364-72. PMID 22031933 DOI: 10.1128/Jvi.05708-11  0.466
2012 Olal D, Kuehne A, Bale S, Halfmann P, Hashiguchi T, Fusco ML, Lee JE, King LB, Kawaoka Y, Dye JM, Saphire EO. Structure of an Ebola Virus-Protective Antibody in Complex with its Mucin-Domain Linear Epitope. Journal of Virology. 86: 2809. DOI: 10.2210/Pdb2Y6S/Pdb  0.503
2011 Bale S, Liu T, Li S, Wang Y, Abelson D, Fusco M, Woods VL, Saphire EO. Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion. Plos Neglected Tropical Diseases. 5: e1395. PMID 22102923 DOI: 10.1371/Journal.Pntd.0001395  0.466
2011 Dias JM, Kuehne AI, Abelson DM, Bale S, Wong AC, Halfmann P, Muhammad MA, Fusco ML, Zak SE, Kang E, Kawaoka Y, Chandran K, Dye JM, Saphire EO. A shared structural solution for neutralizing ebolaviruses. Nature Structural & Molecular Biology. 18: 1424-7. PMID 22101933 DOI: 10.1038/Nsmb.2150  0.535
2011 Hastie KM, Liu T, Li S, King LB, Ngo N, Zandonatti MA, Woods VL, de la Torre JC, Saphire EO. Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding. Proceedings of the National Academy of Sciences of the United States of America. 108: 19365-70. PMID 22084115 DOI: 10.1073/Pnas.1108515108  0.409
2011 Saphire EO, Oldstone MB. Measles virus fusion shifts into gear. Nature Structural & Molecular Biology. 18: 115-6. PMID 21289649 DOI: 10.1038/Nsmb0211-115  0.39
2011 Hastie KM, Kimberlin CR, Zandonatti MA, MacRae IJ, Saphire EO. Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression. Proceedings of the National Academy of Sciences of the United States of America. 108: 2396-401. PMID 21262835 DOI: 10.1073/Pnas.1016404108  0.399
2010 Kimberlin CR, Bornholdt ZA, Li S, Woods VL, MacRae IJ, Saphire EO. Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression. Proceedings of the National Academy of Sciences of the United States of America. 107: 314-9. PMID 20018665 DOI: 10.1073/Pnas.0910547107  0.409
2009 Lee JE, Saphire EO. Ebolavirus glycoprotein structure and mechanism of entry. Future Virology. 4: 621-635. PMID 20198110 DOI: 10.2217/Fvl.09.56  0.52
2009 Lee JE, Fusco ML, Abelson DM, Hessell AJ, Burton DR, Saphire EO. Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein. Acta Crystallographica. Section D, Biological Crystallography. 65: 1162-80. PMID 19923712 DOI: 10.1107/S0907444909032314  0.437
2009 Lee JE, Saphire EO. Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it. Current Opinion in Structural Biology. 19: 408-17. PMID 19559599 DOI: 10.1016/J.Sbi.2009.05.004  0.528
2008 Lee JE, Fusco ML, Hessell AJ, Oswald WB, Burton DR, Saphire EO. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature. 454: 177-82. PMID 18615077 DOI: 10.1038/Nature07082  0.546
2008 Lee JE, Kuehne A, Abelson DM, Fusco ML, Hart MK, Saphire EO. Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda x light chain. Journal of Molecular Biology. 375: 202-16. PMID 18005986 DOI: 10.1016/J.Jmb.2007.10.017  0.497
2008 Lee J, Fusco M, Hessell A, Oswald W, Burton D, Saphire E. Structure of the trimeric prefusionEbolavirus GP complexed with an antibody from a human survivor Acta Crystallographica Section a Foundations of Crystallography. 64: C58-C58. DOI: 10.1107/S0108767308098152  0.471
2007 Saphire EO, Montero M, Menendez A, van Houten NE, Irving MB, Pantophlet R, Zwick MB, Parren PW, Burton DR, Scott JK, Wilson IA. Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies. Journal of Molecular Biology. 369: 696-709. PMID 17445828 DOI: 10.1016/J.Jmb.2007.01.060  0.554
2006 Cárdenas WB, Loo YM, Gale M, Hartman AL, Kimberlin CR, Martínez-Sobrido L, Saphire EO, Basler CF. Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling. Journal of Virology. 80: 5168-78. PMID 16698997 DOI: 10.1128/Jvi.02199-05  0.369
2004 Zwick MB, Saphire EO, Burton DR. gp41: HIV's shy protein. Nature Medicine. 10: 133-4. PMID 14760422 DOI: 10.1038/Nm0204-133  0.365
2003 Scanlan CN, Pantophlet R, Wormald MR, Saphire EO, Calarese D, Stanfield R, Wilson IA, Katinger H, Dwek RA, Burton DR, Rudd PM. The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12. Advances in Experimental Medicine and Biology. 535: 205-18. PMID 14714897 DOI: 10.1007/978-1-4615-0065-0_13  0.744
2003 Saphire EO, Stanfield RL, Crispin MD, Morris G, Zwick MB, Pantophlet RA, Parren PW, Rudd PM, Dwek RA, Burton DR, Wilson IA. Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design. Advances in Experimental Medicine and Biology. 535: 55-66. PMID 14714888 DOI: 10.1007/978-1-4615-0065-0_4  0.559
2003 Stanfield RL, Ghiara JB, Saphire EO, Profy AT, Wilson IA. Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop Virology. 315: 159-173. PMID 14592768 DOI: 10.1016/S0042-6822(03)00525-7  0.547
2003 Zwick MB, Parren PW, Saphire EO, Church S, Wang M, Scott JK, Dawson PE, Wilson IA, Burton DR. Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120. Journal of Virology. 77: 5863-76. PMID 12719580 DOI: 10.1128/Jvi.77.10.5863-5876.2003  0.547
2002 Saphire EO, Stanfield RL, Crispin MD, Parren PW, Rudd PM, Dwek RA, Burton DR, Wilson IA. Contrasting IgG structures reveal extreme asymmetry and flexibility. Journal of Molecular Biology. 319: 9-18. PMID 12051932 DOI: 10.1016/S0022-2836(02)00244-9  0.537
2001 Zwick MB, Labrijn AF, Wang M, Spenlehauer C, Saphire EO, Binley JM, Moore JP, Stiegler G, Katinger H, Burton DR, Parren PW. Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41. Journal of Virology. 75: 10892-905. PMID 11602729 DOI: 10.1128/Jvi.75.22.10892-10905.2001  0.514
2001 Saphire EO, Parren PW. Listening for viral infection. Nature Biotechnology. 19: 823-4. PMID 11533636 DOI: 10.1038/Nbt0901-823  0.333
2001 Saphire EO, Parren PW, Pantophlet R, Zwick MB, Morris GM, Rudd PM, Dwek RA, Stanfield RL, Burton DR, Wilson IA. Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science (New York, N.Y.). 293: 1155-9. PMID 11498595 DOI: 10.1126/Science.1061692  0.582
2001 Burton DR, Saphire EO, Parren PW. A model for neutralization of viruses based on antibody coating of the virion surface. Current Topics in Microbiology and Immunology. 260: 109-43. PMID 11443871 DOI: 10.1007/978-3-662-05783-4_7  0.411
2001 Poignard P, Saphire EO, Parren PW, Burton DR. gp120: Biologic aspects of structural features. Annual Review of Immunology. 19: 253-74. PMID 11244037 DOI: 10.1146/Annurev.Immunol.19.1.253  0.408
2001 Saphire EO, Parren PW, Barbas CF, Burton DR, Wilson IA. Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1. Acta Crystallographica. Section D, Biological Crystallography. 57: 168-71. PMID 11134947 DOI: 10.1107/S0907444900017376  0.569
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