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David L. Pompliano, PhD - Publications

Affiliations: 
2002-2007 Cancer and Anti-Infectives GSK, Rixensart, Wallonie, Belgium 
 2007-2008 Anti-Infectives Merck Research Labs, Boston, MA, United States 
 2009-2013 CEO BioLeap 
 2013-2014 Entrepreneur in Residence Third Rock Ventures 
 2014-2015 Co-founder and Chief Scientific Officer Revolution Medicines 
 2015-2018 Co-founder and Chief Scientific Officer Lodo Therapeutics 
 2021- Co-founder and Chief Innovation Officer Odyssey Therapeutics 
Area:
drug discovery, antimicrobials, oncology, enzymology, natural products, microbiome
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24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2004 Triolo TA, Chabin RM, Pompliano DL. Cloning, expression and characterization of the Streptococcus pyogenes murE gene encoding a UDP-MurNAc-L-alanyl-D-glutamate: L-lysine ligase Enzyme and Microbial Technology. 35: 300-308. DOI: 10.1016/J.Enzmictec.2004.03.020  0.323
2002 Barbosa MD, Lin S, Markwalder JA, Mills JA, DeVito JA, Teleha CA, Garlapati V, Liu C, Thompson A, Trainor GL, Kurilla MG, Pompliano DL. Regulated expression of the Escherichia coli lepB gene as a tool for cellular testing of antimicrobial compounds that inhibit signal peptidase I in vitro. Antimicrobial Agents and Chemotherapy. 46: 3549-54. PMID 12384363 DOI: 10.1128/Aac.46.11.3549-3554.2002  0.312
2002 Glick GD, Pompliano DL. Next-generation therapeutics Current Opinion in Chemical Biology. 6: 415-417. DOI: 10.1016/S1367-5931(02)00354-X  0.502
1999 Hammond GG, Huber JL, Greenlee ML, Laub JB, Young K, Silver LL, Balkovec JM, Pryor KAD, Wu JK, Leiting B, Pompliano DL, Toney JH. Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives Fems Microbiology Letters. 179: 289-296. PMID 10518728 DOI: 10.1111/J.1574-6968.1999.Tb08740.X  0.323
1999 Reddy SG, Waddell ST, Kuo DW, Wong KK, Pompliano DL. Preparative enzymatic synthesis and characterization of the cytoplasmic intermediates of murein biosynthesis Journal of the American Chemical Society. 121: 1175-1178. DOI: 10.1021/Ja983850B  0.309
1998 Toney JH, Fitzgerald PMD, Grover-Sharma N, Olson SH, May WJ, Sundelof JG, Vanderwall DE, Cleary KA, Grant SK, Wu JK, Kozarich JW, Pompliano DL, Hammond GG. Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-β-lactamase Chemistry and Biology. 5: 185-196. PMID 9545432 DOI: 10.1016/S1074-5521(98)90632-9  0.301
1998 El-Sherbeini M, Geissler WM, Pittman J, Yuan X, Wong KK, Pompliano DL. Cloning and expression of Staphylococcus aureus and Streptococcus pyogenes murD genes encoding uridine diphosphate N-acetylmuramoyl-L-alanine:D-glutamate ligases Gene. 210: 117-125. PMID 9524242 DOI: 10.1016/S0378-1119(98)00059-6  0.344
1998 Zeng B, Wong KK, Pompliano DL, Reddy S, Tanner ME. A phosphinate inhibitor of the meso-diaminopimelic acid-adding enzyme (MurE) of peptidoglycan biosynthesis Journal of Organic Chemistry. 63: 10081-10086. DOI: 10.1021/Jo981895P  0.602
1997 Eveland SS, Pompliano DL, Anderson MS. Conditionally lethal Escherichia coli murein mutants contain point defects that map to regions conserved among murein and folyl poly-γ- glutamate ligases: Identification of a ligase superfamily Biochemistry. 36: 6223-6229. PMID 9166795 DOI: 10.1021/Bi9701078  0.369
1997 Toney JH, Wu JK, Overbye KM, Thompson CM, Pompliano DL. High-yield expression, purification, and characterization of active, soluble Bacteroides fragilis metallo-β-lactamase, CcrA Protein Expression and Purification. 9: 355-362. PMID 9126607 DOI: 10.1006/Prep.1996.0718  0.394
1996 Anderson MS, Eveland SS, Onishi HR, Pompliano DL. Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-alanine-adding enzyme: Use of a glutathione S-transferase fusion Biochemistry. 35: 16264-16269. PMID 8973200 DOI: 10.1021/Bi961872+  0.375
1995 Koblan KS, Schaber MD, Edwards G, Gibbs JB, Pompliano DL. src-homology 2 (SH2) domain ligation as an allosteric regulator: Modulation of phosphoinositide-specific phospholipase Cγ1 structure and activity Biochemical Journal. 305: 745-751. PMID 7531435 DOI: 10.1042/Bj3050745  0.348
1993 Pompliano DL. Isoprenoid diphosphate utilization by recombinant human farnesyl:Protein transferase: Interactive binding between substrates and a preferred kinetic pathway Biochemistry. 32: 8341-8347. PMID 8347630 DOI: 10.1021/Bi00083A038  0.33
1992 Pompliano DL, Rands E, Schaber MD, Mosser SD, Anthony NJ, Gibbs JB. Steady-state kinetic mechanism of ras farnesyl:protein transferase Biochemistry. 31: 3800-3807. PMID 1567835 DOI: 10.1021/Bi00130A010  0.332
1992 Seidel HM, Pompliano DL, Knowles JR. Phosphonate biosynthesis: molecular cloning of the gene for phosphoenolpyruvate mutase from Tetrahymena pyriformis and overexpression of the gene product in Escherichia coli. Biochemistry. 31: 2598-608. PMID 1547241 DOI: 10.1021/Bi00124A021  0.588
1992 Seidel HM, Pompliano DL, Knowles JR. Exons as microgenes? Science (New York, N.Y.). 257: 1489-90. PMID 1523407  0.519
1992 Pollack SJ, Freeman S, Pompliano DL, Knowles JR. Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus. European Journal of Biochemistry / Febs. 209: 735-43. PMID 1330557 DOI: 10.1111/J.1432-1033.1992.Tb17342.X  0.645
1992 Draths KM, Pompliano DL, Conley DL, Frost JW, Berry A, Disbrow GL, Staversky RJ, Lievense JC. Biocatalytic synthesis of aromatics from D-glucose: The role of transketolase Journal of the American Chemical Society. 114: 3956-3962. DOI: 10.1021/Ja00036A050  0.655
1990 Pompliano DL, Peyman A, Knowles JR. Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase. Biochemistry. 29: 3186-94. PMID 2185832 DOI: 10.1021/Bi00465A005  0.634
1989 Pompliano DL, Reimer LM, Myrvold S, Frost JW. Probing lethal metabolic perturbations in plants with chemical inhibition of dehydroquinate synthase Journal of the American Chemical Society. 111: 1866-1871. DOI: 10.1021/Ja00187A049  0.622
1989 Myrvold S, Reimer LM, Pompliano DL, Frost JW. Chemical inhibition of dehydroquinate synthase Journal of the American Chemical Society. 111: 1861-1866. DOI: 10.1021/Ja00187A048  0.633
1987 Roach MC, Ungar LW, Zare RN, Reimer LM, Pompliano DL, Frost JW. Fluorescence detection of alkylphosphonic acids using p-(9-anthroyloxy)phenacyl bromide [2] Analytical Chemistry. 59: 1056-1059. DOI: 10.1021/Ac00134A027  0.58
1986 Reimer LM, Conley DL, Pompliano DL, Frost JW. Construction of an enzyme-targeted organophosphonate using immobilized enzyme and whole cell synthesis Journal of the American Chemical Society. 108: 8010-8015. DOI: 10.1021/Ja00285A022  0.659
1986 Cordeiro ML, Pompliano DL, Frost JW. Degradation and detoxification of organophosphonates: Cleavage of the carbon to phosphorus bond Journal of the American Chemical Society. 108: 332-334.  0.576
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