Charles Flexner - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Medicine and Surgery, Epidemiology

127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Shah NS, Kityo C, Hughes MD, McCarthy C, Wallis C, Hosseinipour M, Langat D, Nyirenda M, Rassool M, Dawson R, Joseph Y, Some F, Mngqbisa R, Mukwekwerere PG, Woolley E, ... ... Flexner C, et al. Effectiveness of double-dose dolutegravir in people receiving rifampin-based tuberculosis treatment: an observational, cohort study of people with HIV from six countries. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 38739755 DOI: 10.1093/cid/ciae269  0.344
2023 Delany-Moretlwe S, Flexner C, Bauermeister JA. Advancing use of long-acting and extended delivery HIV prevention and treatment regimens. Journal of the International Aids Society. e26126. PMID 37439079 DOI: 10.1002/jia2.26126  0.393
2022 Flexner C. The future of long-acting agents for preexposure prophylaxis. Current Opinion in Hiv and Aids. 17: 192-198. PMID 35762373 DOI: 10.1097/COH.0000000000000735  0.332
2022 Flexner CW, Kashuba A. Editorial: New drugs for HIV: quo vadis? Current Opinion in Hiv and Aids. 17: 1-3. PMID 34871186 DOI: 10.1097/COH.0000000000000710  0.42
2021 Chandiwana NC, Serenata CM, Owen A, Rannard S, Pérez Casas C, Scott C, Hill A, Clayden P, Flexner C. Impact of long-acting therapies on the global HIV epidemic. Aids (London, England). 35: S137-S143. PMID 34848580 DOI: 10.1097/QAD.0000000000003102  0.407
2021 Hurwitz SJ, Tao S, Gavegnano C, Jiang Y, Tressler R, Tsibris A, Del Rio C, Overton ET, Lederman MM, Kantor A, Moser C, Kohler JJ, Lennox J, Marconi VC, Flexner C, et al. Pharmacokinetics of Ruxolitinib in HIV Suppressed Individuals on Antiretroviral Agents Therapy from the ACTG A5336 Study. Journal of Clinical Pharmacology. PMID 34169526 DOI: 10.1002/jcph.1930  0.374
2021 Phillips AN, Bansi-Matharu L, Cambiano V, Ehrenkranz P, Serenata C, Venter F, Pett S, Flexner CW, Jahn A, Revill P, Garnett GP. The potential role of long-acting injectable cabotegravir-rilpivirine in the treatment of HIV in sub-Saharan Africa: a modelling analysis. The Lancet. Global Health. PMID 33770513 DOI: 10.1016/S2214-109X(21)00025-5  0.354
2021 Marconi VC, Moser C, Gavegnano C, Deeks SG, Lederman MM, Overton ET, Tsibris A, Hunt PW, Kantor A, Sekaly RP, Tressler R, Flexner C, Hurwitz SJ, Moisi D, Clagett B, et al. Randomized Trial of Ruxolitinib in Antiretroviral-Treated Adults with HIV. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 33693561 DOI: 10.1093/cid/ciab212  0.43
2020 Flexner C, Owen A, Siccardi M, Swindells S. LONG-ACTING DRUGS AND FORMULATIONS FOR THE TREATMENT AND PREVENTION OF HIV. International Journal of Antimicrobial Agents. 106220. PMID 33166693 DOI: 10.1016/j.ijantimicag.2020.106220  0.431
2020 Durand CM, Capoferri AA, Redd AD, Zahurak M, Rosenbloom DIS, Cash A, Avery RK, Bolaños-Meade J, Bollard CM, Bullen CK, Flexner C, Fuchs EJ, Gallant J, Gladstone DE, Gocke CD, et al. Allogeneic bone marrow transplantation with post-transplant cyclophosphamide for patients with HIV and haematological malignancies: a feasibility study. The Lancet. Hiv. PMID 32649866 DOI: 10.1016/S2352-3018(20)30073-4  0.434
2020 Rajoli RKR, Demkovich ZR, Flexner C, Owen A, Siccardi M. Predicting pharmacokinetics of a tenofovir alafenamide subcutaneous implant using PBPK modelling. Antimicrobial Agents and Chemotherapy. PMID 32423957 DOI: 10.1128/Aac.00155-20  0.355
2019 Bollinger RC, Thio CL, Sulkowski MS, McKenzie-White J, Thomas DL, Flexner C. Addressing the global burden of hepatitis B virus while developing long-acting injectables for the prevention and treatment of HIV. The Lancet. Hiv. PMID 31870675 DOI: 10.1016/S2352-3018(19)30342-X  0.533
2019 Weld ED, Flexner C. Long-acting implants to treat and prevent HIV infection. Current Opinion in Hiv and Aids. PMID 31764198 DOI: 10.1097/Coh.0000000000000591  0.354
2019 K R Rajoli R, Flexner C, Chiong J, Owen A, Donnelly RF, Larrañeta E, Siccardi M. Modelling the intradermal delivery of microneedle array patches for long-acting antiretrovirals using PBPK. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 31525446 DOI: 10.1016/J.Ejpb.2019.09.011  0.401
2019 Nachman S, Townsend CL, Abrams EJ, Archary M, Capparelli E, Clayden P, Lockman S, Jean-Philippe P, Mayer K, Mirochnick M, McKenzie-White J, Struble K, Watts H, Flexner C. Long-acting or extended-release antiretroviral products for HIV treatment and prevention in infants, children, adolescents, and pregnant and breastfeeding women: knowledge gaps and research priorities. The Lancet. Hiv. PMID 31307946 DOI: 10.1016/S2352-3018(19)30147-X  0.311
2019 Hobson JJ, Al-Khouja A, Curley P, Meyers D, Flexner C, Siccardi M, Owen A, Meyers CF, Rannard SP. Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies. Nature Communications. 10: 1413. PMID 30926773 DOI: 10.1038/S41467-019-09354-Z  0.34
2018 Kent SJ, Flexner C. Ageing in patients with chronic HIV infection: impact of hypercoagulation. Aids Research and Therapy. 15: 22. PMID 30474565 DOI: 10.1186/s12981-018-0211-1  0.398
2018 Weld ED, Rana MS, Dallas RH, Camacho-Gonzalez AF, Ryscavage P, Gaur AH, Chakraborty R, Swindells S, Flexner C, Agwu AL. Interest of Youth Living with HIV in Long-Acting Antiretrovirals. Journal of Acquired Immune Deficiency Syndromes (1999). PMID 30418298 DOI: 10.1097/QAI.0000000000001896  0.392
2018 Flexner C. Modern HIV Therapy: Progress and Prospects. Clinical Pharmacology and Therapeutics. PMID 30411787 DOI: 10.1002/cpt.1284  0.377
2018 Flexner C, Thomas DL, Swindells S. Creating demand for long-acting formulations for the treatment and prevention of HIV, tuberculosis, and viral hepatitis. Current Opinion in Hiv and Aids. PMID 30394948 DOI: 10.1097/Coh.0000000000000510  0.35
2018 Gulick RM, Flexner C. Long-Acting HIV Drugs for Treatment and Prevention. Annual Review of Medicine. PMID 30355266 DOI: 10.1146/annurev-med-041217-013717  0.401
2018 Monroe M, Flexner C, Cui H. Harnessing nanostructured systems for improved treatment and prevention of HIV disease. Bioengineering & Translational Medicine. 3: 102-123. PMID 30065966 DOI: 10.1002/btm2.10096  0.376
2017 Smith JM, Flexner C. The challenge of polypharmacy in an aging population and implications for future antiretroviral therapy development. Aids (London, England). 31: S173-S184. PMID 28471948 DOI: 10.1097/QAD.0000000000001401  0.364
2017 Maartens G, Boffito M, Flexner C. Compatibility of next-generation first-line antiretrovirals with rifampicin-based antituberculosis therapy in resource limited settings. Current Opinion in Hiv and Aids. PMID 28403028 DOI: 10.1097/COH.0000000000000376  0.302
2017 Jacobson JM, Flexner C. Universal antiretroviral regimens: thinking beyond one-pill-once-a-day. Current Opinion in Hiv and Aids. PMID 28368868 DOI: 10.1097/COH.0000000000000374  0.417
2016 Jacobson J, Bosinger S, Kang M, Belaunzaran-Zamudio P, Matining RM, Wilson C, Flexner CW, Clagett B, Plants J, Read S, Purdue L, Myers L, Boone L, Tebas P, Kumar P, et al. The Effect of Chloroquine on Immune Activation and Interferon Signatures Associated with HIV-1. Aids Research and Human Retroviruses. PMID 26935044 DOI: 10.1089/Aid.2015.0336  0.473
2016 Hennig S, Svensson EM, Niebecker R, Fourie PB, Weiner MH, Bonora S, Peloquin CA, Gallicano K, Flexner C, Pym A, Vis P, Olliaro PL, McIlleron H, Karlsson MO. Population pharmacokinetic drug-drug interaction pooled analysis of existing data for rifabutin and HIV PIs. The Journal of Antimicrobial Chemotherapy. PMID 26832753 DOI: 10.1093/Jac/Dkv470  0.504
2015 Nelson AG, Zhang X, Ganapathi U, Szekely Z, Flexner CW, Owen A, Sinko PJ. Drug delivery strategies and systems for HIV/AIDS pre-exposure prophylaxis and treatment. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 26315816 DOI: 10.1016/J.Jconrel.2015.08.042  0.481
2015 Rajoli RK, Back DJ, Rannard S, Freel Meyers CL, Flexner C, Owen A, Siccardi M. Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV. Clinical Pharmacokinetics. 54: 639-50. PMID 25523214 DOI: 10.1007/S40262-014-0227-1  0.495
2015 Cash A, Capoferri A, Xu D, Mchugh H, Laeyendecker O, Sakoian S, Tony L, Bullen C, Pohlmeyer C, Pham P, Lai J, Gallant J, Siliciano R, Flexner C, Pratz K, et al. Safety of Optimized Antiretroviral Therapy During Allogeneic Matched and Haploidentical Bone Marrow Transplant in HIV+ Individuals Open Forum Infectious Diseases. 2. DOI: 10.1093/Ofid/Ofv131.83  0.402
2014 Vitoria M, Ford N, Doherty M, Flexner C. Simplification of antiretroviral therapy: a necessary step in the public health response to HIV/AIDS in resource-limited settings. Antiviral Therapy. 19: 31-7. PMID 25310534 DOI: 10.3851/IMP2898  0.334
2014 Zheng L, Taiwo B, Gandhi RT, Hunt PW, Collier AC, Flexner C, Bosch RJ. Factors associated with CD8+ T-cell activation in HIV-1-infected patients on long-term antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes (1999). 67: 153-60. PMID 25072610 DOI: 10.1097/QAI.0000000000000286  0.348
2013 Flexner C, Saag M. The antiretroviral drug pipeline: prospects and implications for future treatment research. Current Opinion in Hiv and Aids. 8: 572-8. PMID 24100879 DOI: 10.1097/Coh.0000000000000011  0.459
2013 Flexner C, Plumley B, Brown Ripin DH. Treatment optimization: an outline for future success. Current Opinion in Hiv and Aids. 8: 523-7. PMID 24100878 DOI: 10.1097/Coh.0000000000000003  0.35
2013 Ford N, Flexner C, Vella S, Ripin D, Vitoria M. Optimization and simplification of antiretroviral therapy for adults and children. Current Opinion in Hiv and Aids. 8: 591-9. PMID 24100871 DOI: 10.1097/Coh.0000000000000010  0.396
2013 Ribaudo HJ, Smith KY, Robbins GK, Flexner C, Haubrich R, Chen Y, Fischl MA, Schackman BR, Riddler SA, Gulick RM. Racial differences in response to antiretroviral therapy for HIV infection: an AIDS clinical trials group (ACTG) study analysis. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 57: 1607-17. PMID 24046302 DOI: 10.1093/Cid/Cit595  0.468
2013 Andrade A, Rosenkranz SL, Cillo AR, Lu D, Daar ES, Jacobson JM, Lederman M, Acosta EP, Campbell T, Feinberg J, Flexner C, Mellors JW, Kuritzkes DR. Three distinct phases of HIV-1 RNA decay in treatment-naive patients receiving raltegravir-based antiretroviral therapy: ACTG A5248. The Journal of Infectious Diseases. 208: 884-91. PMID 23801609 DOI: 10.1093/Infdis/Jit272  0.427
2013 Williams J, Sayles HR, Meza JL, Sayre P, Sandkovsky U, Gendelman HE, Flexner C, Swindells S. Long-acting parenteral nanoformulated antiretroviral therapy: interest and attitudes of HIV-infected patients. Nanomedicine (London, England). 8: 1807-13. PMID 23611617 DOI: 10.2217/Nnm.12.214  0.441
2013 Durand CM, Flexner C. HIV cure: Knocking on the door Clinical Pharmacology and Therapeutics. 93: 382-384. PMID 23598454 DOI: 10.1038/clpt.2013.22  0.438
2013 Dooley KE, Sayre P, Borland J, Purdy E, Chen S, Song I, Peppercorn A, Everts S, Piscitelli S, Flexner C. Safety, tolerability, and pharmacokinetics of the HIV integrase inhibitor dolutegravir given twice daily with rifampin or once daily with rifabutin: results of a phase 1 study among healthy subjects. Journal of Acquired Immune Deficiency Syndromes (1999). 62: 21-7. PMID 23075918 DOI: 10.1097/Qai.0B013E318276Cda9  0.515
2012 Lee LS, Pham P, Flexner C. Unexpected drug-drug interactions in human immunodeficiency virus (HIV) therapy: induction of UGT1A1 and bile efflux transporters by Efavirenz. Annals of the Academy of Medicine, Singapore. 41: 559-62. PMID 23303112  0.329
2012 Chen J, Flexner C, Liberman RG, Skipper PL, Louissaint NA, Tannenbaum SR, Hendrix CW, Fuchs EJ. Biphasic elimination of tenofovir diphosphate and nonlinear pharmacokinetics of zidovudine triphosphate in a microdosing study. Journal of Acquired Immune Deficiency Syndromes (1999). 61: 593-9. PMID 23187888 DOI: 10.1097/Qai.0B013E3182717C98  0.348
2012 Crawford KW, Ripin DH, Levin AD, Campbell JR, Flexner C. Optimising the manufacture, formulation, and dose of antiretroviral drugs for more cost-efficient delivery in resource-limited settings: a consensus statement. The Lancet. Infectious Diseases. 12: 550-60. PMID 22742638 DOI: 10.1016/S1473-3099(12)70134-2  0.385
2012 Dooley KE, Park JG, Swindells S, Allen R, Haas DW, Cramer Y, Aweeka F, Wiggins I, Gupta A, Lizak P, Qasba S, van Heeswijk R, Flexner C. Safety, tolerability, and pharmacokinetic interactions of the antituberculous agent TMC207 (bedaquiline) with efavirenz in healthy volunteers: AIDS Clinical Trials Group Study A5267. Journal of Acquired Immune Deficiency Syndromes (1999). 59: 455-62. PMID 22126739 DOI: 10.1097/Qai.0B013E3182410503  0.404
2011 Wang L, Soon GH, Seng KY, Li J, Lee E, Yong EL, Goh BC, Flexner C, Lee L. Pharmacokinetic modeling of plasma and intracellular concentrations of raltegravir in healthy volunteers. Antimicrobial Agents and Chemotherapy. 55: 4090-5. PMID 21746959 DOI: 10.1128/Aac.00593-11  0.322
2011 Rudek MA, Flexner C, Ambinder RF. Use of antineoplastic agents in patients with cancer who have HIV/AIDS. The Lancet. Oncology. 12: 905-12. PMID 21570912 DOI: 10.1016/S1470-2045(11)70056-0  0.463
2011 Wang LZ, Lee LS, Thuya WL, Soon GH, Kong LR, Nye PL, Lee EJ, Flexner C, Goh BC. Simultaneous determination of raltegravir and raltegravir glucuronide in human plasma by liquid chromatography-tandem mass spectrometric method. Journal of Mass Spectrometry : Jms. 46: 202-8. PMID 21259392 DOI: 10.1002/Jms.1874  0.325
2011 Pham PA, Flexner C. Emerging antiretroviral drug interactions. The Journal of Antimicrobial Chemotherapy. 66: 235-9. PMID 21131695 DOI: 10.1093/Jac/Dkq448  0.375
2010 Wilkin TJ, Su Z, Krambrink A, Long J, Greaves W, Gross R, Hughes MD, Flexner C, Skolnik PR, Coakley E, Godfrey C, Hirsch M, Kuritzkes DR, Gulick RM. Three-year safety and efficacy of vicriviroc, a CCR5 antagonist, in HIV-1-infected treatment-experienced patients. Journal of Acquired Immune Deficiency Syndromes (1999). 54: 470-6. PMID 20672447 DOI: 10.1097/Qai.0B013E3181E2Cba0  0.485
2010 Crawford KW, Spritzler J, Kalayjian RC, Parsons T, Landay A, Pollard R, Stocker V, Lederman MM, Flexner C. Age-related changes in plasma concentrations of the HIV protease inhibitor lopinavir. Aids Research and Human Retroviruses. 26: 635-43. PMID 20560793 DOI: 10.1089/Aid.2009.0154  0.466
2010 Soon GH, Shen P, Yong EL, Pham P, Flexner C, Lee L. Pharmacokinetics of darunavir at 900 milligrams and ritonavir at 100 milligrams once daily when coadministered with efavirenz at 600 milligrams once daily in healthy volunteers. Antimicrobial Agents and Chemotherapy. 54: 2775-80. PMID 20385850 DOI: 10.1128/Aac.01564-09  0.371
2010 Flexner C, Tierney C, Gross R, Andrade A, Lalama C, Eshleman SH, Aberg J, Sanne I, Parsons T, Kashuba A, Rosenkranz SL, Kmack A, Ferguson E, Dehlinger M, Mildvan D, et al. Comparison of once-daily versus twice-daily combination antiretroviral therapy in treatment-naive patients: results of AIDS clinical trials group (ACTG) A5073, a 48-week randomized controlled trial. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 50: 1041-52. PMID 20192725 DOI: 10.1086/651118  0.454
2010 Crawford KW, Li C, Keung A, Su Z, Hughes MD, Greaves W, Kuritzkes D, Gulick R, Flexner C. Pharmacokinetic/pharmacodynamic modeling of the antiretroviral activity of the CCR5 antagonist Vicriviroc in treatment experienced HIV-infected subjects (ACTG protocol 5211). Journal of Acquired Immune Deficiency Syndromes (1999). 53: 598-605. PMID 20071999 DOI: 10.1097/QAI.0b013e3181c9caac  0.429
2009 Pham PA, la Porte CJ, Lee LS, van Heeswijk R, Sabo JP, Elgadi MM, Piliero PJ, Barditch-Crovo P, Fuchs E, Flexner C, Cameron DW. Differential effects of tipranavir plus ritonavir on atorvastatin or rosuvastatin pharmacokinetics in healthy volunteers. Antimicrobial Agents and Chemotherapy. 53: 4385-92. PMID 19667285 DOI: 10.1128/Aac.00449-09  0.306
2009 Gross R, Tierney C, Andrade A, Lalama C, Rosenkranz S, Eshleman SH, Flanigan T, Santana J, Salomon N, Reisler R, Wiggins I, Hogg E, Flexner C, Mildvan D. Modified directly observed antiretroviral therapy compared with self-administered therapy in treatment-naive HIV-1-infected patients: a randomized trial. Archives of Internal Medicine. 169: 1224-32. PMID 19597072 DOI: 10.1001/Archinternmed.2009.172  0.395
2009 Tsibris AM, Korber B, Arnaout R, Russ C, Lo CC, Leitner T, Gaschen B, Theiler J, Paredes R, Su Z, Hughes MD, Gulick RM, Greaves W, Coakley E, Flexner C, et al. Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo. Plos One. 4: e5683. PMID 19479085 DOI: 10.1371/Journal.Pone.0005683  0.311
2008 Andrade AS, Hendrix C, Parsons TL, Caballero B, Yuan CS, Flexner CW, Dobs AS, Brown TT. Pharmacokinetic and metabolic effects of American ginseng (Panax quinquefolius) in healthy volunteers receiving the HIV protease inhibitor indinavir. Bmc Complementary and Alternative Medicine. 8: 50. PMID 18713456 DOI: 10.1186/1472-6882-8-50  0.447
2008 Tsibris AM, Sagar M, Gulick RM, Su Z, Hughes M, Greaves W, Subramanian M, Flexner C, Giguel F, Leopold KE, Coakley E, Kuritzkes DR. In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject. Journal of Virology. 82: 8210-4. PMID 18495779 DOI: 10.1128/JVI.00444-08  0.305
2008 Lee LS, Wise SD, Chan C, Parsons TL, Flexner C, Lietman PS. Possible differential induction of phase 2 enzyme and antioxidant pathways by american ginseng, Panax quinquefolius. Journal of Clinical Pharmacology. 48: 599-609. PMID 18319359 DOI: 10.1177/0091270008314252  0.362
2008 Cao YJ, Flexner CW, Dunaway S, Park JG, Klingman K, Wiggins I, Conley J, Radebaugh C, Kashuba AD, MacFarland R, Becker S, Hendrix CW. Effect of low-dose ritonavir on the pharmacokinetics of the CXCR4 antagonist AMD070 in healthy volunteers. Antimicrobial Agents and Chemotherapy. 52: 1630-4. PMID 18285477 DOI: 10.1128/AAC.01460-07  0.505
2008 Willard S, Flexner C. Introduction: The changing face of HIV Journal of the International Association of Physicians in Aids Care. 7. DOI: 10.1177/1545109708315400  0.381
2007 Bakshi RP, Hamzeh F, Frank I, Eron JJ, Bosch RJ, Rosenkranz SL, Cramer YS, Ussery M, Flexner C. Effect of hydroxyurea and dideoxyinosine on intracellular 3'-deoxyadenosine-5'-triphosphate concentrations in HIV-infected patients. Aids Research and Human Retroviruses. 23: 1360-5. PMID 18184078 DOI: 10.1089/Aid.2007.0078  0.485
2007 Flexner C. HIV drug development: the next 25 years. Nature Reviews. Drug Discovery. 6: 959-66. PMID 17932493 DOI: 10.1038/Nrd2336  0.454
2007 Podzamczer D, King MS, Klein CE, Flexner C, Katlama C, Havlir DV, Letendre SL, Eron JJ, Brun SC, Bernstein B. High-dose lopinavir/ritonavir in highly treatment-experienced HIV-1 patients: efficacy, safety, and predictors of response. Hiv Clinical Trials. 8: 193-204. PMID 17720659 DOI: 10.1310/Hct0804-193  0.422
2007 Gulick RM, Su Z, Flexner C, Hughes MD, Skolnik PR, Wilkin TJ, Gross R, Krambrink A, Coakley E, Greaves WL, Zolopa A, Reichman R, Godfrey C, Hirsch M, Kuritzkes DR, et al. Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211. The Journal of Infectious Diseases. 196: 304-12. PMID 17570119 DOI: 10.1086/518797  0.534
2007 Stone ND, Dunaway SB, Flexner C, Tierney C, Calandra GB, Becker S, Cao YJ, Wiggins IP, Conley J, MacFarland RT, Park JG, Lalama C, Snyder S, Kallungal B, Klingman KL, et al. Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects. Antimicrobial Agents and Chemotherapy. 51: 2351-8. PMID 17452489 DOI: 10.1128/Aac.00013-07  0.553
2007 Pham PA, Flexner C, Parsons T, Vasist L, Fuchs E, Carson K, Agarwala S, Barditch-Crovo P. Beneficial pharmacokinetic interaction between atazanavir and lopinavir/ritonavir. Journal of Acquired Immune Deficiency Syndromes (1999). 45: 201-5. PMID 17414932 DOI: 10.1097/Qai.0B013E318050D632  0.45
2007 Wilkin TJ, Su Z, Kuritzkes DR, Hughes M, Flexner C, Gross R, Coakley E, Greaves W, Godfrey C, Skolnik PR, Timpone J, Rodriguez B, Gulick RM. HIV type 1 chemokine coreceptor use among antiretroviral-experienced patients screened for a clinical trial of a CCR5 inhibitor: AIDS Clinical Trial Group A5211. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 44: 591-5. PMID 17243065 DOI: 10.1086/511035  0.389
2006 De Gruttola V, Flexner C, Schapiro J, Hughes M, Van Der Laan M, Kuritzkes DR. Drug development strategies for salvage therapy: conflicts and solutions. Aids Research and Human Retroviruses. 22: 1106-9. PMID 17147496 DOI: 10.1089/Aid.2006.22.1106  0.369
2006 Nettles RE, Kieffer TL, Parsons T, Johnson J, Cofrancesco J, Gallant JE, Carson KA, Siliciano RF, Flexner C. Marked intraindividual variability in antiretroviral concentrations may limit the utility of therapeutic drug monitoring. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 42: 1189-96. PMID 16575741 DOI: 10.1086/501458  0.413
2005 Nettles RE, Keiffer TL, Cofrancesco J, Gallant JE, Quinn T, Jackson B, Flexner C, Carson KA, Wu AW, Siliciano RF. Psychological distress and physical pain appear to have no short-term adverse impact on plasma HIV-1 RNA levels in patients on successful HAART. Hiv Clinical Trials. 6: 262-71. PMID 16425464 DOI: 10.1310/5X2L-Mvy7-Yqtb-Ebaj  0.349
2005 Flexner C. Update from the 6th International Workshop on the Clinical Pharmacology of HIV Therapy: new drugs, new formulations and drug interactions. The Hopkins Hiv Report : a Bimonthly Newsletter For Healthcare Providers / Johns Hopkins University Aids Service. 17: 1-3, 10-1. PMID 16419306  0.335
2005 Back DJ, Burger DM, Flexner CW, Gerber JG. The pharmacology of antiretroviral nucleoside and nucleotide reverse transcriptase inhibitors: implications for once-daily dosing. Journal of Acquired Immune Deficiency Syndromes (1999). 39: S1-23, quiz S24-25. PMID 15990598 DOI: 10.1097/01.qai.0000168882.67942.3f  0.316
2005 Boffito M, Acosta E, Burger D, Fletcher CV, Flexner C, Garaffo R, Gatti G, Kurowski M, Perno CF, Peytavin G, Regazzi M, Back D. Current status and future prospects of therapeutic drug monitoring and applied clinical pharmacology in antiretroviral therapy. Antiviral Therapy. 10: 375-92. PMID 15918329  0.301
2005 Nettles RE, Kieffer TL, Kwon P, Monie D, Han Y, Parsons T, Cofrancesco J, Gallant JE, Quinn TC, Jackson B, Flexner C, Carson K, Ray S, Persaud D, Siliciano RF. Intermittent HIV-1 viremia (Blips) and drug resistance in patients receiving HAART. Jama. 293: 817-29. PMID 15713771 DOI: 10.1001/Jama.293.7.817  0.429
2004 Frank I, Bosch RJ, Fiscus S, Valentine F, Flexner C, Segal Y, Ruan P, Gulick R, Wood K, Estep S, Fox L, Nevin T, Stevens M, Eron JJ. Activity, safety, and immunological effects of hydroxyurea added to didanosine in antiretroviral-naive and experienced HIV type 1-infected subjects: a randomized, placebo-controlled trial, ACTG 307. Aids Research and Human Retroviruses. 20: 916-26. PMID 15597521 DOI: 10.1089/Aid.2004.20.916  0.427
2004 Hendrix CW, Collier AC, Lederman MM, Schols D, Pollard RB, Brown S, Jackson JB, Coombs RW, Glesby MJ, Flexner CW, Bridger GJ, Badel K, MacFarland RT, Henson GW, Calandra G, et al. Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection. Journal of Acquired Immune Deficiency Syndromes (1999). 37: 1253-62. PMID 15385732 DOI: 10.1097/01.Qai.0000137371.80695.Ef  0.452
2004 Tapper ML, Flexner C, Eron JJ, Molina JM. Simplifying antiretroviral therapy. The Aids Reader. 14: 355-60, 367-71. PMID 15282865  0.345
2004 Rufo PA, Lin PW, Andrade A, Jiang L, Rameh L, Flexner C, Alper SL, Lencer WI. Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling. American Journal of Physiology. Cell Physiology. 286: C998-C1008. PMID 15075198 DOI: 10.1152/Ajpcell.00357.2003  0.409
2003 Washington CB, Flexner C, Sheiner LB, Rosenkranz SL, Segal Y, Aberg JA, Blaschke TF. Effect of simultaneous versus staggered dosing on pharmacokinetic interactions of protease inhibitors. Clinical Pharmacology and Therapeutics. 73: 406-16. PMID 12732841 DOI: 10.1016/S0009-9236(03)00006-7  0.31
2003 Flexner CW. Advances in HIV pharmacology: protein binding, pharmacogenomics, and therapeutic drug monitoring. Topics in Hiv Medicine : a Publication of the International Aids Society, Usa. 11: 40-4. PMID 12717040  0.362
2003 Rufo P, Lin PW, Andrade A, Flexner C, Jiang L, Alper SL, Lencer WI. HIV-1 protease inhibitors potentiate muscarinic stimulation of Clȡ secretion in association with increased and prolonged Ca2+ entry in T84 cells Gastroenterology. 124: A144. DOI: 10.1016/S0016-5085(03)80714-X  0.44
2002 Lucas GM, Flexner CW, Moore RD. Directly administered antiretroviral therapy in the treatment of HIV infection: benefit or burden? Aids Patient Care and Stds. 16: 527-35. PMID 12513901 DOI: 10.1089/108729102761041083  0.337
2002 Lu JF, Blaschke TF, Flexner C, Rosenkranz SL, Sheiner LB. Model-based analysis of the pharmacokinetic interactions between ritonavir, nelfinavir, and saquinavir after simultaneous and staggered oral administration. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 1455-61. PMID 12433819 DOI: 10.1124/Dmd.30.12.1455  0.301
2002 Acosta EP, Fletcher CV, Flexner C, Haas D, Hall S, Hamzeh F, Haubrich R, Kashuba A, Katzenstein D, Lawrence J, Lertora J, Gerber JG, Para M, Rosenkranz S, Sheiner L, et al. Position paper on therapeutic drug monitoring of antiretroviral agents Aids Research and Human Retroviruses. 18: 825-834. PMID 12201904 DOI: 10.1089/08892220260190290  0.364
2002 Kresina TF, Flexner CW, Sinclair J, Correia MA, Stapleton JT, Adeniyi-Jones S, Cargill V, Cheever LW. Alcohol use and HIV pharmacotherapy. Aids Research and Human Retroviruses. 18: 757-70. PMID 12167267 DOI: 10.1089/08892220260139495  0.319
2002 Speck RR, Yu XF, Hildreth J, Flexner C. Differential effects of p-glycoprotein and multidrug resistance protein-1 on productive human immunodeficiency virus infection. The Journal of Infectious Diseases. 186: 332-40. PMID 12134229 DOI: 10.1086/341464  0.713
2002 Flexner CW, Piscitelli SC. Concentration-targeted therapy and the future of HIV management. Aids (London, England). 16: S1-3. PMID 12035819  0.352
2001 Flexner C. The future of HIV treatment: I left my HAART in the 20th century The Hopkins Hiv Report : a Bimonthly Newsletter For Healthcare Providers / Johns Hopkins University Aids Service. 13: 3-5. PMID 11682854  0.374
2001 Gerber JG, Rosenkranz S, Segal Y, Aberg J, D'Amico R, Mildvan D, Gulick R, Hughes V, Flexner C, Aweeka F, Hsu A, Gal J. Effect of ritonavir/saquinavir on stereoselective pharmacokinetics of methadone: results of AIDS Clinical Trials Group (ACTG) 401. Journal of Acquired Immune Deficiency Syndromes (1999). 27: 153-60. PMID 11404537 DOI: 10.1097/00126334-200106010-00010  0.368
2001 Ratner L, Lee J, Tang S, Redden D, Hamzeh F, Herndier B, Scadden D, Kaplan L, Ambinder R, Levine A, Harrington W, Grochow L, Flexner C, Tan B, Straus D. Chemotherapy for human immunodeficiency virus-associated non-Hodgkin's lymphoma in combination with highly active antiretroviral therapy Journal of Clinical Oncology. 19: 2171-2178. PMID 11304769 DOI: 10.1200/Jco.2001.19.8.2171  0.379
2001 Flexner CW, Cargill VA, Sinclair J, Kresina TF, Cheever L. Alcohol use can result in enhanced drug metabolism in HIV pharmacotherapy Aids Patient Care and Stds. 15: 57-58. PMID 11224929 DOI: 10.1089/108729101300003636  0.319
2001 Lederman M, Mosier D, Arts E, Letvin N, Flexner C, Blauvelt A, Cairns S, Bridges S, Sarver N, Offord R. Rationale for testing chemokine inhibitors (Virustats) for prevention of HIV-1 transmission. Aids. 15: S57-S58. DOI: 10.1097/00002030-200102001-00081  0.498
2000 Andrade A, Flexner C. HIV-related drug metabolism and cytochrome P450 enzymes Aids Clinical Care. 12: 91-95. PMID 2002150695  0.366
2000 Flexner C, Bartlett JG. Complications of HIV therapy The Hopkins Hiv Report : a Bimonthly Newsletter For Healthcare Providers / Johns Hopkins University Aids Service. 12. PMID 12184226  0.396
2000 Raines CP, Flexner C, Sun E, Heath-Chiozzi M, Lewis RH, Fields C, Deetz C, Apuzzo L, Eshleman SH, Jackson JB, Gallant JE. Safety, tolerability, and antiretroviral effects of ritonavir-nelfinavir combination therapy administered for 48 weeks. Journal of Acquired Immune Deficiency Syndromes (1999). 25: 322-8. PMID 11114832 DOI: 10.1097/00042560-200012010-00005  0.438
2000 Dowell P, Flexner C, Kwiterovich PO, Lane MD. Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors. The Journal of Biological Chemistry. 275: 41325-32. PMID 11018036 DOI: 10.1074/Jbc.M006474200  0.467
2000 Flexner C. Dual protease inhibitor therapy in HIV-infected patients: Pharmacologic rationale and clinical benefits Annual Review of Pharmacology and Toxicology. 40: 649-674. PMID 10836150  0.46
2000 Speck RR, Flexner C, Tian CJ, Yu XF. Comparison of human immunodeficiency virus type 1 Pr55(Gag) and Pr160(Gag-pol) processing intermediates that accumulate in primary and transformed cells treated with peptidic and nonpeptidic protease inhibitors. Antimicrobial Agents and Chemotherapy. 44: 1397-403. PMID 10770790 DOI: 10.1128/Aac.44.5.1397-1403.2000  0.723
2000 Lin PW, Rufo PA, Flexner C, Lencer WI. The HIV-1 protease inhibitor nelfinvir enhances CA++-dependent Cl- secretion in intestinal T84 cell monolayers Gastroenterology. 118: A607. DOI: 10.1016/S0016-5085(00)84566-7  0.439
1999 Finzi D, Blankson J, Siliciano JD, Margolick JB, Chadwick K, Pierson T, Smith K, Lisziewicz J, Lori F, Flexner C, Quinn TC, Chaisson RE, Rosenberg E, Walker B, Gange S, et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nature Medicine. 5: 512-7. PMID 10229227 DOI: 10.1038/8394  0.396
1999 Ratner L, Redden D, Hamzeh F, Levine A, Harrington W, Scadden D, Kaplan L, Ambinder R, Grochow L, Flexner C, Tan B, Straus D. CHEMOTHERAPY FOR HIV-ASSOCIATED NON-HODGKIN LYMPHOMA (HIV-NHL) IN COMBINATION WITH HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) IS NOT ASSOCIATED WITH EXCESSIVE TOXICITY. Jaids: Journal of Acquired Immune Deficiency Syndromes. 21: A32. DOI: 10.1097/00126334-199905010-00112  0.505
1998 Flexner C. Fat city: understanding HIV lipodystrophy The Hopkins Hiv Report : a Bimonthly Newsletter For Healthcare Providers / Johns Hopkins University Aids Service. 10: 14-15. PMID 11365774  0.406
1998 Di Perri G, Del Bravo P, Concia E, Palleja S, Flexner CW. HIV-protease inhibitors [4] (multiple letters) New England Journal of Medicine. 339: 773-774. PMID 9742031 DOI: 10.1056/NEJM199809103391115  0.438
1998 Maenza J, Flexner C. Combination antiretroviral therapy for HIV infection American Family Physician. 57: 2789-2798. PMID 9636341  0.377
1998 Flexner C. HIV-protease inhibitors New England Journal of Medicine. 338: 1281-1292. PMID 9562584 DOI: 10.1056/Nejm199804303381808  0.558
1998 Yu XF, Dawson L, Tian CJ, Flexner C, Dettenhofer M. Mutations of the human immunodeficiency virus type 1 p6(Gag) domain result in reduced retention of pol proteins during virus assembly Journal of Virology. 72: 3412-3417. PMID 9525672 DOI: 10.1128/Jvi.72.4.3412-3417.1998  0.448
1997 Fischl MA, Richman DD, Flexner C, Para MF, Haubrich R, Karim A, Yeramian P, Holden-Wiltse J, Meehan PM. Phase I/II study of the toxicity, pharmacokinetics, and activity of the HIV protease inhibitor SC-52151 Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 15: 28-34. PMID 9215651 DOI: 10.1097/00042560-199705010-00005  0.413
1997 Sharma UK, Song HF, Willingham FF, Hannig J, Flexner C, Farzadegan H, Nicolau C, Schwartz DH. Diagnosis of human immunodeficiency virus infection using citrated whole blood. Clinical and Diagnostic Laboratory Immunology. 4: 261-3. PMID 9144360  0.369
1997 Piscitelli SC, Flexner C, Minor JR, Polis MA, Masur H. Drug interactions in patients infected with human immunodeficiency virus. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 23: 685-93. PMID 8909827 DOI: 10.1093/Clinids/23.4.685  0.382
1997 Hammond JMJ, Hannig J, Schwartz D, Flexner C. Survival kinetics of autologous erythrocytes (RBCs) modified by electroinsertion of recombinant CD4 Clinical Pharmacology and Therapeutics. 61: 193.  0.359
1996 Heldman AW, Hartert TV, Ray SC, Daoud EG, Kowalski TE, Pompili VJ, Sisson SD, Tidmore WC, Vom Eigen KA, Goodman SN, Lietman PS, Petty BG, Flexner C. Oral antibiotic treatment of right-sided staphylococcal endocarditis in injection drug users: Prospective randomized comparison with parenteral therapy American Journal of Medicine. 101: 68-76. PMID 8686718 DOI: 10.1016/S0002-9343(96)00070-8  0.319
1996 Tosi PF, Schwartz D, Sharma U, Mouneimne Y, Hannig J, Li G, McKinley G, Grieco M, Flexner CW, Lazarte J, Norse D, Nicolau C, Volsky DJ. Human erythrocytes bearing electroinserted CD4 neutralize infection in vitro by primary isolates of human immunodeficiency virus type 1. Blood. 87: 4839-44. PMID 8639857  0.369
1995 Dezube BJ, Lederman MM, Spritzler JG, Chapman B, Korvick JA, Flexner C, Dando S, Mattiacci MR, Ahlers CM, Zhang L, Novick WJ, Kasdan P, Fahey JL, Pardee AB, Crumpacker CS. High-dose pentoxifylline in patients with AIDS: Inhibition of tumor necrosis factor production Journal of Infectious Diseases. 171: 1628-1632. PMID 7769305 DOI: 10.1093/Infdis/171.6.1628  0.334
1995 Haubrich RH, Flexner C, Lederman MM, Hirsch M, Pettinelli CP, Ginsberg R, Lietman P, Hamzeh FM, Spector SA, Richman DD, Hammer S, Cooley T, Gulick R, Sullivan M, Spina C, et al. A randomized trial of the activity and safety of ro 24-7429 (tat antagonist) versus nucleoside for human immunodeficiency virus infection Journal of Infectious Diseases. 172: 1246-1252. PMID 7594660 DOI: 10.1093/Infdis/172.5.1246  0.488
1995 Chavan SJ, Bornmann WG, Flexner C, Prochaska HJ. Inactivation of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by Oltipraz: Evidence for the Formation of a Stable Adduct Archives of Biochemistry and Biophysics. 324: 143-152. PMID 7503549 DOI: 10.1006/abbi.1995.9916  0.37
1994 Hendrix CW, Flexner C, Szebeni J, Kuwahara S, Pennypacker S, Weinstein JN, Lietman PS. Effect of dipyridamole on zidovudine pharmacokinetics and short-term tolerance in asymptomatic human immunodeficiency virus-infected subjects Antimicrobial Agents and Chemotherapy. 38: 1036-1040. PMID 8067734 DOI: 10.1128/Aac.38.5.1036  0.402
1994 Flexner C, Van Der Horst C, Jacobson MA, Powderly W, Duncanson F, Ganes D, Barditch-Crovo PA, Petty BG, Baron PA, Armstrong D, Bricmont P, Kuye O, Yacobi A, Desjardins R, Polsky B. Relationship between plasma concentrations of 3‘-deoxy-3’-fluorothymidine (alovudine) and antiretroviral activity in two concentration-controlled trials Journal of Infectious Diseases. 170: 1394-1403. PMID 7995977 DOI: 10.1093/infdis/170.6.1394  0.388
1992 Stein D, Corey L, Volberding P, Jermano J, Dixon D, Feldstein M, Flexner C, Freeman D, Grieco M, Havlir D, Leedom J, Mitsuyasu R, Para M, Sacks H, Seidlin M. Preliminary safety and activity evaluation of new agents for the treatment of HIV-1 infection: Recommended guidelines for trial design Controlled Clinical Trials. 13: 388. DOI: 10.1016/0197-2456(92)90069-C  0.437
1991 Moore RD, Kessler H, Richman DD, Flexner C, Chaisson RE. Non-Hodgkin’s Lymphoma in Patients With Advanced HIV Infection Treated With Zidovudine Jama: the Journal of the American Medical Association. 265: 2208-2211. PMID 2013953 DOI: 10.1001/Jama.1991.03460170062034  0.419
1991 Flexner C, Barditch-Crovo PA, Kornhauser DM, Farzadegan H, Nerhood LJ, Chaisson RE, Bell KM, Lorentsen KJ, Hendrix CW, Petty BG, Lietman PS. Pharmacokinetics, toxicity, and activity of intravenous dextran sulfate in human immunodeficiency virus infection Antimicrobial Agents and Chemotherapy. 35: 2544-2550. PMID 1810188 DOI: 10.1128/Aac.35.12.2544  0.565
1991 Flexner C, Barditch-Crovo P, Kornhauser D, Nerhood L, Hendrix C, Lorentsen K, Farzadegan H, Petty B, Lietman P. Intravenous dextran sulfate (DS) increases circulating HIV antigen levels in patients with ARC or AIDS Antiviral Research. 15: 125. DOI: 10.1016/0166-3542(91)90240-R  0.487
1990 Hosmalin A, Clerici M, Houghten R, Pendleton CD, Flexner C, Lucey DR, Moss B, Germain RN, Shearer GM, Berzofsky JA. An epitope in human immunodeficiency virus 1 reverse transcriptase recognized by both mouse and human cytotoxic T lymphocytes Proceedings of the National Academy of Sciences of the United States of America. 87: 2344-2348. PMID 1690429 DOI: 10.1073/Pnas.87.6.2344  0.416
1989 Walker BD, Flexner C, Birch-Limberger K, Fisher L, Paradis TJ, Aldovini A, Young R, Moss B, Schooley RT. Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1 Proceedings of the National Academy of Sciences of the United States of America. 86: 9514-9518. PMID 2480604 DOI: 10.1073/Pnas.86.23.9514  0.344
1989 Lorentsen KJ, Hendrix CW, Collins JM, Kornhauser DM, Petty BG, Klecker RW, Flexner C, Eckel RH, Lietman PS. Dextran sulfate is poorly absorbed after oral administration Annals of Internal Medicine. 111: 561-566. PMID 2476054 DOI: 10.7326/0003-4819-111-7-561  0.334
1988 Flexner C, Broyles SS, Earl P, Chakrabarti S, Moss B. Characterization of human immunodeficiency virus gag/pol gene products expressed by recombinant vaccinia viruses Virology. 166: 339-349. PMID 2459842 DOI: 10.1016/0042-6822(88)90504-1  0.442
1988 Walker BD, Flexner C, Paradis TJ, Fuller TC, Hirsch MS, Schooley RT, Moss B. HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals Science. 240: 64-66. PMID 2451288 DOI: 10.1126/Science.2451288  0.437
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