| Year |
Citation |
Score |
| 2024 |
Flotte TR. The Road Less Traveled: Slow but Steady Progress Toward Cystic Fibrosis Gene Therapy by UK Respiratory Gene Therapy Consortium. American Journal of Respiratory and Critical Care Medicine. PMID 39265185 DOI: 10.1164/rccm.202408-1516ED |
0.305 |
|
| 2023 |
Arjomandnejad M, Dasgupta I, Flotte TR, Keeler AM. Immunogenicity of Recombinant Adeno-Associated Virus (AAV) Vectors for Gene Transfer. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 1-19. PMID 36862289 DOI: 10.1007/s40259-023-00585-7 |
0.313 |
|
| 2020 |
Tang Q, Keeler AM, Zhang S, Su Q, Lyu Z, Cheng Y, Gao G, Flotte TR. Two-Plasmid Packaging System for Recombinant Adeno-Associated Virus. Bioresearch Open Access. 9: 219-228. PMID 33117614 DOI: 10.1089/biores.2020.0031 |
0.354 |
|
| 2018 |
Flotte TR. Airway Basal Cells Are the Key for Cystic Fibrosis Gene Therapy. Human Gene Therapy. 29: 641-642. PMID 29902084 DOI: 10.1089/hum.2018.29066.trf |
0.311 |
|
| 2018 |
Wang D, Li S, Gessler DJ, Xie J, Zhong L, Li J, Tran K, Van Vliet K, Ren L, Su Q, He R, Goetzmann JE, Flotte TR, Agbandje-McKenna M, Gao G. A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates. Molecular Therapy. Methods & Clinical Development. 9: 234-246. PMID 29766031 DOI: 10.1016/J.Omtm.2018.03.004 |
0.335 |
|
| 2017 |
Borel F, Tang Q, Gernoux G, Greer C, Wang Z, Barzel A, Kay MA, Shultz LD, Greiner DL, Flotte TR, Brehm MA, Mueller C. Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29032169 DOI: 10.1016/J.Ymthe.2017.09.020 |
0.302 |
|
| 2017 |
Flotte TR. Adeno-Associated Virus-Human Bocavirus 1 Chimeric Vectors: Ferreting Out Their Role in Airway Gene Therapy. Human Gene Therapy. 28: 611. PMID 28796554 DOI: 10.1089/hum.2017.29047.trf |
0.362 |
|
| 2016 |
Loring HS, ElMallah MK, Flotte TR. Development of RAAV2-CFTR: History of the First RAAV Vector Product to be Used in Humans. Human Gene Therapy Methods. PMID 26895204 DOI: 10.1089/hgtb.2015.150 |
0.382 |
|
| 2015 |
Gruntman AM, Flotte TR. Progress with Recombinant Adeno-Associated Virus Vectors for Gene Therapy of Alpha-1 Antitrypsin Deficiency. Human Gene Therapy Methods. 26: 77-81. PMID 26067712 DOI: 10.1089/hgtb.2015.086 |
0.331 |
|
| 2015 |
Borel F, Choudhury S, Aslanidi G, Song L, Kocabas E, Sun H, Tang Q, Srivastava A, Wagner K, Esteves M, Flotte T, Mueller C. 183. Developing Strategies To Improve the Current Clinical Vector AAV1-CB-AAT for Alpha-One Antitrypsin Deficiency Molecular Therapy. 23: S73. DOI: 10.1016/S1525-0016(16)33788-1 |
0.416 |
|
| 2013 |
Flotte TR. Birth of a new therapeutic platform: 47 years of adeno-associated virus biology from virus discovery to licensed gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1976-81. PMID 24201212 DOI: 10.1038/mt.2013.226 |
0.311 |
|
| 2013 |
Mueller C, Flotte TR. Gene-based therapy for alpha-1 antitrypsin deficiency. Copd. 10: 44-9. PMID 23527792 DOI: 10.3109/15412555.2013.764978 |
0.306 |
|
| 2013 |
Gruntman AM, Bish LT, Mueller C, Sweeney HL, Flotte TR, Gao G. Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus. Current Protocols in Microbiology. Unit 14D.3. PMID 23408131 DOI: 10.1002/9780471729259.Mc14D03S28 |
0.331 |
|
| 2013 |
Bickford JS, Mueller C, Newsom KJ, Barilovits SJ, Beachy DE, Herlihy JD, Keeler B, Flotte TR, Nick HS. Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 12: 258-65. PMID 22985691 DOI: 10.1016/J.Jcf.2012.08.014 |
0.307 |
|
| 2012 |
Gruntman AM, Mueller C, Flotte TR, Gao G. Gene transfer in the lung using recombinant adeno-associated virus. Current Protocols in Microbiology. Unit14D.2. PMID 22875566 DOI: 10.1002/9780471729259.Mc14D02S26 |
0.32 |
|
| 2010 |
Mueller C, Strayer MS, Sirninger J, Braag S, Branco F, Louboutin JP, Flotte TR, Strayer DS. In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors. Gene Therapy. 17: 227-37. PMID 19890354 DOI: 10.1038/gt.2009.137 |
0.392 |
|
| 2010 |
Flotte TR, Fischer AC, Goetzmann J, Mueller C, Cebotaru L, Yan Z, Wang L, Wilson JM, Guggino WB, Engelhardt JF. Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 594-600. PMID 19826405 DOI: 10.1038/Mt.2009.230 |
0.327 |
|
| 2009 |
Liqun Wang R, McLaughlin T, Cossette T, Tang Q, Foust K, Campbell-Thompson M, Martino A, Cruz P, Loiler S, Mueller C, Flotte TR. Recombinant AAV serotype and capsid mutant comparison for pulmonary gene transfer of alpha-1-antitrypsin using invasive and noninvasive delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 81-7. PMID 18941444 DOI: 10.1038/Mt.2008.217 |
0.337 |
|
| 2008 |
Mueller C, Flotte TR. Gene therapy for cystic fibrosis. Clinical Reviews in Allergy & Immunology. 35: 164-78. PMID 18600482 DOI: 10.1007/s12016-008-8080-3 |
0.36 |
|
| 2008 |
Silver JN, Flotte TR. Towards a rAAV-based gene therapy for ADA-SCID: from ADA deficiency to current and future treatment strategies. Pharmacogenomics. 9: 947-68. PMID 18597656 DOI: 10.2217/14622416.9.7.947 |
0.349 |
|
| 2008 |
Cebotaru L, Vij N, Ciobanu I, Wright J, Flotte T, Guggino WB. Cystic fibrosis transmembrane regulator missing the first four transmembrane segments increases wild type and DeltaF508 processing. The Journal of Biological Chemistry. 283: 21926-33. PMID 18508776 DOI: 10.1074/Jbc.M709156200 |
0.322 |
|
| 2008 |
Mueller C, Flotte TR. Clinical gene therapy using recombinant adeno-associated virus vectors. Gene Therapy. 15: 858-63. PMID 18418415 DOI: 10.1038/gt.2008.68 |
0.35 |
|
| 2008 |
Mueller C, Torrez D, Braag S, Martino A, Clarke T, Campbell-Thompson M, Flotte TR. Partial correction of the CFTR-dependent ABPA mouse model with recombinant adeno-associated virus gene transfer of truncated CFTR gene. The Journal of Gene Medicine. 10: 51-60. PMID 18023072 DOI: 10.1002/Jgm.1119 |
0.314 |
|
| 2008 |
Snyder R, Potter M, Phillipsberg G, Phillipsberg T, Petersen M, Sanders D, Fife J, Korytov I, Zolotukhin S, Muzyczka N, Francis J, Flotte T. Manufacture and Stability of the Recombinant Adeno-Associated Virus Serotype 2 Vector Reference Standard Bioprocessing Journal. 7: 8-14. DOI: 10.12665/J72.Snyder |
0.373 |
|
| 2007 |
Flotte TR. Gene therapy: the first two decades and the current state-of-the-art. Journal of Cellular Physiology. 213: 301-5. PMID 17577203 DOI: 10.1002/jcp.21173 |
0.37 |
|
| 2007 |
Fischer AC, Smith CI, Cebotaru L, Zhang X, Askin FB, Wright J, Guggino SE, Adams RJ, Flotte T, Guggino WB. Expression of a truncated cystic fibrosis transmembrane conductance regulator with an AAV5-pseudotyped vector in primates. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 756-63. PMID 17299412 DOI: 10.1038/Sj.Mt.6300059 |
0.485 |
|
| 2007 |
Flotte TR, Ng P, Dylla DE, McCray PB, Wang G, Kolls JK, Hu J. Viral vector-mediated and cell-based therapies for treatment of cystic fibrosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 229-41. PMID 17235299 DOI: 10.1038/sj.mt.6300002 |
0.328 |
|
| 2006 |
Stalvey MS, Muller C, Schatz DA, Wasserfall CH, Campbell-Thompson ML, Theriaque DW, Flotte TR, Atkinson MA. Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury. Diabetes. 55: 1939-45. PMID 16804061 DOI: 10.2337/Db05-1647 |
0.379 |
|
| 2006 |
Müller C, Braag SA, Herlihy JD, Wasserfall CH, Chesrown SE, Nick HS, Atkinson MA, Flotte TR. Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice. Laboratory Investigation; a Journal of Technical Methods and Pathology. 86: 130-40. PMID 16424881 DOI: 10.1038/Labinvest.3700379 |
0.368 |
|
| 2006 |
Conlon TJ, Walter G, Owen R, Cossette T, Erger K, Gutierrez G, Goetzman E, Matern D, Vockley J, Flotte TR. Systemic correction of a fatty acid oxidation defect by intramuscular injection of a recombinant adeno-associated virus vector. Human Gene Therapy. 17: 71-80. PMID 16409126 DOI: 10.1089/Hum.2006.17.71 |
0.683 |
|
| 2006 |
Cebotaru L, Flotte TR, Guggino WB. 498. AAV Δ264CFTR Enhances Maturation of ΔF508CFTR and wt CFTR Expression Molecular Therapy. 13: S193. DOI: 10.1016/J.Ymthe.2006.08.568 |
0.383 |
|
| 2005 |
Flotte TR. Adeno-associated virus-based gene therapy for inherited disorders. Pediatric Research. 58: 1143-7. PMID 16306183 DOI: 10.1203/01.pdr.0000189226.03684.fe |
0.365 |
|
| 2005 |
Conlon TJ, Cossette T, Erger K, Choi YK, Clarke T, Scott-Jorgensen M, Song S, Campbell-Thompson M, Crawford J, Flotte TR. Efficient hepatic delivery and expression from a recombinant adeno-associated virus 8 pseudotyped alpha1-antitrypsin vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 867-75. PMID 16085464 DOI: 10.1016/j.ymthe.2005.05.016 |
0.346 |
|
| 2005 |
Flotte TR, Schwiebert EM, Zeitlin PL, Carter BJ, Guggino WB. Correlation between DNA transfer and cystic fibrosis airway epithelial cell correction after recombinant adeno-associated virus serotype 2 gene therapy. Human Gene Therapy. 16: 921-8. PMID 16076250 DOI: 10.1089/Hum.2005.16.921 |
0.346 |
|
| 2005 |
Loiler SA, Tang Q, Clarke T, Campbell-Thompson ML, Chiodo V, Hauswirth W, Cruz P, Perret-Gentil M, Atkinson MA, Ramiya VK, Flotte TR. Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 519-27. PMID 15979413 DOI: 10.1016/J.Ymthe.2005.04.017 |
0.325 |
|
| 2005 |
Flotte TR. Recent developments in recombinant AAV-mediated gene therapy for lung diseases. Current Gene Therapy. 5: 361-6. PMID 15975013 DOI: 10.2174/1566523054064986 |
0.328 |
|
| 2005 |
Flotte TR. Adeno-associated virus-mediated gene transfer for lung diseases. Human Gene Therapy. 16: 643-8. PMID 15960596 DOI: 10.1089/hum.2005.16.643 |
0.306 |
|
| 2005 |
Virella-Lowell I, Zusman B, Foust K, Loiler S, Conlon T, Song S, Chesnut KA, Ferkol T, Flotte TR. Enhancing rAAV vector expression in the lung. The Journal of Gene Medicine. 7: 842-50. PMID 15838934 DOI: 10.1002/Jgm.759 |
0.384 |
|
| 2005 |
Chen S, Kapturczak M, Loiler SA, Zolotukhin S, Glushakova OY, Madsen KM, Samulski RJ, Hauswirth WW, Campbell-Thompson M, Berns KI, Flotte TR, Atkinson MA, Tisher CC, Agarwal A. Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors. Human Gene Therapy. 16: 235-47. PMID 15761263 DOI: 10.1089/Hum.2005.16.235 |
0.348 |
|
| 2005 |
Mohiuddin I, Loiler S, Zolotukhin I, Byrne BJ, Flotte TR, Snyder RO. Herpesvirus-based infectious titering of recombinant adeno-associated viral vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 320-6. PMID 15668144 DOI: 10.1016/J.Ymthe.2004.08.030 |
0.344 |
|
| 2004 |
Byoung BS, Nakamaru-Ogiso E, Cruz P, Flotte TR, Yagi T, Matsuno-Yagi A. Functional expression of the single subunit NADH dehydrogenase in mitochondria in vivo: A potential therapy for complex I deficiencies Human Gene Therapy. 15: 887-895. PMID 15353043 DOI: 10.1089/hum.2004.15.887 |
0.304 |
|
| 2004 |
Sirninger J, Muller C, Braag S, Tang Q, Yue H, Detrisac C, Ferkol T, Guggino WB, Flotte TR. Functional characterization of a recombinant adeno-associated virus 5-pseudotyped cystic fibrosis transmembrane conductance regulator vector Human Gene Therapy. 15: 832-841. PMID 15353038 DOI: 10.1089/Hum.2004.15.832 |
0.663 |
|
| 2004 |
Virella-Lowell I, Herlihy JD, Liu B, Lopez C, Cruz P, Muller C, Baker HV, Flotte TR. Effects of CFTR, interleukin-10, and Pseudomonas aeruginosa on gene expression profiles in a CF bronchial epithelial cell Line. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 562-73. PMID 15336656 DOI: 10.1016/J.Ymthe.2004.06.215 |
0.456 |
|
| 2004 |
Conlon TJ, Flotte TR. Recombinant adeno-associated virus vectors for gene therapy. Expert Opinion On Biological Therapy. 4: 1093-101. PMID 15268676 DOI: 10.1517/14712598.4.7.1093 |
0.333 |
|
| 2004 |
Flotte TR. Gene therapy progress and prospects: Recombinant adeno-associated virus (rAAV) vectors Gene Therapy. 11: 805-810. PMID 15042119 DOI: 10.1038/sj.gt.3302233 |
0.378 |
|
| 2004 |
Flotte TR, Brantly ML, Spencer LT, Byrne BJ, Spencer CT, Baker DJ, Humphries M. Phase I trial of intramuscular injection of a recombinant adeno-associated virus alpha 1-antitrypsin (rAAV2-CB-hAAT) gene vector to AAT-deficient adults. Human Gene Therapy. 15: 93-128. PMID 14965381 DOI: 10.1089/10430340460732490 |
0.329 |
|
| 2004 |
Zhang YC, Powers M, Wasserfall C, Brusko T, Song S, Flotte T, Snyder RO, Potter M, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Nick HS, Agarwal A, Ellis TM, Atkinson MA. Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity. Gene Therapy. 11: 233-40. PMID 14737082 DOI: 10.1038/Sj.Gt.3302144 |
0.416 |
|
| 2004 |
Song S, Goudy K, Campbell-Thompson M, Wasserfall C, Scott-Jorgensen M, Wang J, Tang Q, Crawford JM, Ellis TM, Atkinson MA, Flotte TR. Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice Gene Therapy. 11: 181-186. PMID 14712302 DOI: 10.1038/Sj.Gt.3302156 |
0.37 |
|
| 2003 |
Fischer AC, Beck SE, Smith CI, Laube BL, Askin FB, Guggino SE, Adams RJ, Flotte TR, Guggino WB. Successful transgene expression with serial doses of aerosolized rAAV2 vectors in rhesus macaques. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 918-26. PMID 14664794 DOI: 10.1016/J.Ymthe.2003.08.015 |
0.324 |
|
| 2003 |
Flotte TR, Zeitlin PL, Reynolds TC, Heald AE, Pedersen P, Beck S, Conrad CK, Brass-Ernst L, Humphries M, Sullivan K, Wetzel R, Taylor G, Carter BJ, Guggino WB. Phase I trial of intranasal and endobronchial administration of a recombinant adeno-associated virus serotype 2 (rAAV2)-CFTR vector in adult cystic fibrosis patients: a two-part clinical study. Human Gene Therapy. 14: 1079-88. PMID 12885347 DOI: 10.1089/104303403322124792 |
0.362 |
|
| 2003 |
Stacpoole PW, Owen R, Flotte TR. The pyruvate dehydrogenase complex as a target for gene therapy Current Gene Therapy. 3: 239-245. PMID 12762482 DOI: 10.2174/1566523034578320 |
0.702 |
|
| 2003 |
Chen S, Agarwal A, Glushakova OY, Jorgensen MS, Salgar SK, Poirier A, Flotte TR, Croker BP, Madsen KM, Atkinson MA, Hauswirth WW, Berns KI, Tisher CC. Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors. Journal of the American Society of Nephrology : Jasn. 14: 947-58. PMID 12660329 DOI: 10.1097/01.Asn.0000057858.45649.F7 |
0.317 |
|
| 2003 |
Zhang YC, Pileggi A, Agarwal A, Molano RD, Powers M, Brusko T, Wasserfall C, Goudy K, Zahr E, Poggioli R, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Nick H, Flotte T, et al. Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice. Diabetes. 52: 708-16. PMID 12606512 DOI: 10.2337/Diabetes.52.3.708 |
0.323 |
|
| 2002 |
Zhang YC, Molano RD, Pileggi A, Powers M, Cross J, Wasserfall C, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Flotte T, Ellis TM, Ricordi C, Atkinson MA, Inverardi L. Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation. Transplantation. 74: 1184-6. PMID 12438968 DOI: 10.1097/00007890-200210270-00022 |
0.304 |
|
| 2002 |
Owen R, Mandel RJ, Ammini CV, Conlon TJ, Kerr DS, Stacpoole PW, Flotte TR. Gene therapy for pyruvate dehydrogenase E1alpha deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 394-9. PMID 12231176 DOI: 10.1006/Mthe.2002.0683 |
0.725 |
|
| 2002 |
Mah C, Byrne BJ, Flotte TR. Virus-based gene delivery systems Clinical Pharmacokinetics. 41: 901-911. PMID 12222993 DOI: 10.2165/00003088-200241120-00001 |
0.349 |
|
| 2002 |
Mah C, Fraites TJ, Zolotukhin I, Song S, Flotte TR, Dobson J, Batich C, Byrne BJ. Improved method of recombinant AAV2 delivery for systemic targeted gene therapy Molecular Therapy. 6: 106-112. PMID 12095310 DOI: 10.1006/Mthe.2001.0636 |
0.349 |
|
| 2002 |
Flotte TR, Virella-Lowell I, Chesnut KA. Adeno-associated viral vectors for CF gene therapy Methods in Molecular Medicine. 70: 599-608. PMID 11917554 DOI: 10.1385/1-59259-187-6:599 |
0.379 |
|
| 2002 |
Flotte TR. Recombinant adeno-associated virus gene therapy for cystic fibrosis and α1-antitrypsin deficiency Chest. 121: 98S-102S. PMID 11893723 |
0.353 |
|
| 2002 |
Kapturczak M, Zolotukhin S, Cross J, Pileggi A, Molano RD, Jorgensen M, Byrne B, Flotte TR, Ellis T, Inverardi L, Ricordi C, Nick H, Atkinson M, Agarwal A. Transduction of human and mouse pancreatic islet cells using a bicistronic recombinant adeno-associated viral vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 154-60. PMID 11829522 DOI: 10.1006/Mthe.2002.0522 |
0.346 |
|
| 2001 |
Kapturczak MH, Flotte T, Atkinson MA. Adeno-Associated Virus (AAV) as a vehicle for therapeutic gene delivery: Improvements in vector design and viral production enhance potential to prolong graft survival in pancreatic islet cell transplantation for the reversal of type 1 diabetes Current Molecular Medicine. 1: 245-258. PMID 11899074 DOI: 10.2174/1566524013363979 |
0.42 |
|
| 2001 |
Flotte TR. Recombinant adeno-associated virus vectors for cystic fibrosis gene therapy Current Opinion in Molecular Therapeutics. 3: 497-502. PMID 11699895 |
0.382 |
|
| 2001 |
Donsante A, Vogler C, Muzyczka N, Crawford JM, Barker J, Flotte T, Campbell-Thompson M, Daly T, Sands MS. Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors. Gene Therapy. 8: 1343-6. PMID 11571571 DOI: 10.1038/Sj.Gt.3301541 |
0.334 |
|
| 2001 |
Song S, Embury J, Laipis PJ, Berns KI, Crawford JM, Flotte TR. Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors. Gene Therapy. 8: 1299-306. PMID 11571566 DOI: 10.1038/Sj.Gt.3301422 |
0.393 |
|
| 2001 |
Flotte TR, Laube BL. Gene therapy in cystic fibrosis. Chest. 120: 124S-131S. PMID 11555567 |
0.389 |
|
| 2001 |
Xu L, Daly T, Gao C, Flotte TR, Song S, Byrne BJ, Sands MS, Parker Ponder K. CMV-beta-actin promoter directs higher expression from an adeno-associated viral vector in the liver than the cytomegalovirus or elongation factor 1 alpha promoter and results in therapeutic levels of human factor X in mice. Human Gene Therapy. 12: 563-73. PMID 11268288 DOI: 10.1089/104303401300042500 |
0.335 |
|
| 2001 |
Flotte T, Agarwal A, Wang J, Song S, Fenjves ES, Inverardi L, Chesnut K, Afione S, Loiler S, Wasserfall C, Kapturczak M, Ellis T, Nick H, Atkinson M. Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors. Diabetes. 50: 515-20. PMID 11246870 DOI: 10.2337/Diabetes.50.3.515 |
0.448 |
|
| 2001 |
Seo BB, Wang J, Flotte TR, Yagi T, Matsuno-Yagi A. Use of the NADH-quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae as a possible cure for complex I defects in human cells. The Journal of Biological Chemistry. 275: 37774-8. PMID 10982813 DOI: 10.1074/jbc.M007033200 |
0.304 |
|
| 2001 |
Flotte TR, Owen R. Response to A. de Grey Antioxidants & Redox Signaling. 3: 1155-1155. DOI: 10.1089/152308601317203675 |
0.61 |
|
| 2000 |
Owen R IV, Lewin AP, Peel A, Wang J, Guy J, Hauswirth WW, Stacpoole PW, Flotte TR. Recombinant adeno-associated virus vector-based gene transfer for defects in oxidative metabolism. Human Gene Therapy. 11: 2067-78. PMID 11044909 DOI: 10.1089/104303400750001381 |
0.359 |
|
| 2000 |
Wu P, Xiao W, Conlon T, Hughes J, Agbandje-McKenna M, Ferkol T, Flotte T, Muzyczka N. Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism. Journal of Virology. 74: 8635-47. PMID 10954565 DOI: 10.1128/Jvi.74.18.8635-8647.2000 |
0.384 |
|
| 1999 |
Wagner JA, Messner AH, Moran ML, Daifuku R, Kouyama K, Desch JK, Manley S, Norbash AM, Conrad CK, Friborg S, Reynolds T, Guggino WB, Moss RB, Carter BJ, Wine JJ, ... Flotte TR, et al. Safety and biological efficacy of an adeno-associated virus vector-cystic fibrosis transmembrane regulator (AAV-CFTR) in the cystic fibrosis maxillary sinus. The Laryngoscope. 109: 266-74. PMID 10890777 DOI: 10.1097/00005537-199902000-00017 |
0.34 |
|
| 1999 |
Owen R, Lewin AS, Wang J, Hauswirth WW, Stacpoole PW, Flotte TR. Adeno-Associated Virus (AAV)-Based Gene Therapy for Defects in Oxidative Metabolism Pediatric Research. 45: 140A-140A. DOI: 10.1203/00006450-199904020-00833 |
0.696 |
|
| 1999 |
Beck SE, Jones LA, Chesnut K, Walsh SM, Reynolds TC, Carter BJ, Askin FB, Flotte TR, Guggino WB. Repeated Delivery of Adeno-Associated Virus Vectors to the Rabbit Airway Journal of Virology. 73: 9446-9455. DOI: 10.1128/jvi.73.11.9446-9455.1999 |
0.354 |
|
| 1998 |
Flotte TR, Carter BJ. Adeno-associated virus vectors for gene therapy of cystic fibrosis Methods in Enzymology. 292: 717-732. PMID 9711594 DOI: 10.1016/S0076-6879(98)92055-9 |
0.395 |
|
| 1998 |
Flotte TR, Beck SE, Chesnut K, Potter M, Poirier A, Zolotukhin S. A fluorescence video-endoscopy technique for defection of gene transfer and expression Gene Therapy. 5: 166-173. PMID 9578835 DOI: 10.1038/Sj.Gt.3300579 |
0.373 |
|
| 1997 |
Rubenstein RC, McVeigh U, Flotte TR, Guggino WB, Zeitlin PL. CFTR gene transduction in neonatal rabbits using an adeno-associated virus (AAV) vector. Gene Therapy. 4: 384-92. PMID 9274714 DOI: 10.1038/Sj.Gt.3300417 |
0.433 |
|
| 1997 |
Flotte TR, Carter BJ. In Vivo Gene Therapy with Adeno-Associated Virus Vectors for Cystic Fibrosis Advances in Pharmacology. 40: 85-101. PMID 9217924 DOI: 10.1016/S1054-3589(08)60138-6 |
0.407 |
|
| 1996 |
Baudard M, Flotte TR, Aran JM, Thierry AR, Pastan I, Pang MG, Kearns WG, Gottesman MM. Expression of the human multidrug resistance and glucocerebrosidase cDNAs from adeno-associated vectors: efficient promoter activity of AAV sequences and in vivo delivery via liposomes. Human Gene Therapy. 7: 1309-22. PMID 8818718 DOI: 10.1089/Hum.1996.7.11-1309 |
0.317 |
|
| 1996 |
Carter BJ, Flotte TR. Development of adeno-associated virus vectors for gene therapy of cystic fibrosis Current Topics in Microbiology and Immunology. 218: 119-144. PMID 8794249 |
0.391 |
|
| 1996 |
Flotte T, Carter B, Conrad C, Guggino W, Reynolds T, Rosenstein B, Taylor G, Walden S, Wetzel R. A Phase I Study of an Adeno-Associated Virus-CFTR Gene Vector in Adult CF Patients with Mild Lung Disease. Johns Hopkins Children's Center, Baltimore, Maryland Human Gene Therapy. 7: 1145-1159. PMID 8773517 DOI: 10.1089/Hum.1996.7.9-1145 |
0.392 |
|
| 1995 |
Flotte TR, Carter BJ. Adeno-associated virus vectors for gene therapy Gene Therapy. 2: 357-362. PMID 7584109 |
0.407 |
|
| 1994 |
Flotte TR, Afione SA, Zeitlin PL. Adeno-associated virus vector gene expression occurs in nondividing cells in the absence of vector DNA integration. American Journal of Respiratory Cell and Molecular Biology. 11: 517-21. PMID 7946381 DOI: 10.1165/ajrcmb.11.5.7946381 |
0.326 |
|
| 1994 |
Schwiebert EM, Flotte T, Cutting GR, Guggino WB. Both CFTR and outwardly rectifying chloride channels contribute to cAMP- stimulated whole cell chloride currents American Journal of Physiology - Cell Physiology. 266. PMID 7515570 DOI: 10.1152/Ajpcell.1994.266.5.C1464 |
0.304 |
|
| 1993 |
Flotte TR. Prospects for virus-based gene therapy for cystic fibrosis Journal of Bioenergetics and Biomembranes. 25: 37-42. PMID 8382676 DOI: 10.1007/BF00768066 |
0.41 |
|
| 1993 |
Flotte TR, Afione SA, Conrad C, McGrath SA, Solow R, Oka H, Zeitlin PL, Guggino WB, Carter BJ. Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector. Proceedings of the National Academy of Sciences of the United States of America. 90: 10613-7. PMID 7504271 DOI: 10.1073/Pnas.90.22.10613 |
0.409 |
|
| 1992 |
Egan M, Flotte T, Afione S, Solow R, Zeitlin PL, Carter BJ, Guggino WB. Defective regulation of outwardly rectifying Cl- channels by protein kinase a corrected by insertion of CFTR Nature. 358: 581-584. PMID 1380129 DOI: 10.1038/358581A0 |
0.341 |
|
| 1992 |
Flotte TR, Solow R, Owens RA, Afione S, Zeitlin PL, Carter BJ. Gene expression from adeno-associated virus vectors in airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 7: 349-56. PMID 1325813 DOI: 10.1165/ajrcmb/7.3.349 |
0.399 |
|
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