James C. Alwine - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Microbiology Biology

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Goodrum F, Lowen A, Lakdawala S, Alwine J, Casadevall A, Imperiale M, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, et al. Virology under the Microscope-a Call for Rational Discourse. Msphere. e0003423. PMID 36700653 DOI: 10.1128/msphere.00034-23  0.522
2023 Goodrum F, Lowen A, Lakdawala S, Alwine J, Casadevall A, Imperiale M, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, et al. Virology under the Microscope-a Call for Rational Discourse. Mbio. e0018823. PMID 36700642 DOI: 10.1128/mbio.00188-23  0.522
2023 Goodrum F, Lowen A, Lakdawala S, Alwine J, Casadevall A, Imperiale M, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, et al. Virology under the Microscope-a Call for Rational Discourse. Journal of Virology. e0008923. PMID 36700640 DOI: 10.1128/jvi.00089-23  0.522
2018 Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, et al. Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell. PMID 29861175 DOI: 10.1016/J.Cell.2018.05.009  0.325
2017 Banerjee S, Tian T, Wei Z, Peck KN, Shih N, Chalian AA, O'Malley BW, Weinstein GS, Feldman MD, Alwine J, Robertson ES. Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas. Scientific Reports. 7: 4036. PMID 28642609 DOI: 10.1038/S41598-017-03466-6  0.304
2017 Vysochan A, Sengupta A, Weljie AM, Alwine JC, Yu Y. ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection. Proceedings of the National Academy of Sciences of the United States of America. PMID 28167750 DOI: 10.1073/Pnas.1614268114  0.367
2014 Shenk T, Alwine JC. Human Cytomegalovirus: Coordinating Cellular Stress, Signaling, and Metabolic Pathways. Annual Review of Virology. 1: 355-74. PMID 26958726 DOI: 10.1146/Annurev-Virology-031413-085425  0.404
2014 Baldwin DA, Feldman M, Alwine JC, Robertson ES. Metagenomic assay for identification of microbial pathogens in tumor tissues. Mbio. 5: e01714-14. PMID 25227467 DOI: 10.1128/Mbio.01714-14  0.302
2014 Yu Y, Maguire TG, Alwine JC. ChREBP, a glucose-responsive transcriptional factor, enhances glucose metabolism to support biosynthesis in human cytomegalovirus-infected cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 1951-6. PMID 24449882 DOI: 10.1073/Pnas.1310779111  0.402
2013 Yu Y, Pierciey FJ, Maguire TG, Alwine JC. PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection. Plos Pathogens. 9: e1003266. PMID 23592989 DOI: 10.1371/journal.ppat.1003266  0.41
2012 Clippinger AJ, Alwine JC. Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells. Genes & Development. 26: 2015-26. PMID 22987636 DOI: 10.1101/Gad.196147.112  0.359
2012 Yu Y, Maguire TG, Alwine JC. Human cytomegalovirus infection induces adipocyte-like lipogenesis through activation of sterol regulatory element binding protein 1. Journal of Virology. 86: 2942-9. PMID 22258239 DOI: 10.1128/JVI.06467-11  0.403
2011 Tilton C, Clippinger AJ, Maguire T, Alwine JC. Human cytomegalovirus induces multiple means to combat reactive oxygen species. Journal of Virology. 85: 12585-93. PMID 21937645 DOI: 10.1128/Jvi.05572-11  0.441
2011 Yu Y, Clippinger AJ, Pierciey FJ, Alwine JC. Viruses and metabolism: alterations of glucose and glutamine metabolism mediated by human cytomegalovirus. Advances in Virus Research. 80: 49-67. PMID 21762821 DOI: 10.1016/B978-0-12-385987-7.00003-8  0.384
2011 Clippinger AJ, Maguire TG, Alwine JC. Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation. Journal of Virology. 85: 9369-76. PMID 21734039 DOI: 10.1128/Jvi.05102-11  0.365
2011 Clippinger AJ, Maguire TG, Alwine JC. The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection. Journal of Virology. 85: 3930-9. PMID 21307192 DOI: 10.1128/Jvi.01913-10  0.482
2010 Buchkovich NJ, Yu Y, Pierciey FJ, Alwine JC. Human cytomegalovirus induces the endoplasmic reticulum chaperone BiP through increased transcription and activation of translation by using the BiP internal ribosome entry site. Journal of Virology. 84: 11479-86. PMID 20739513 DOI: 10.1128/Jvi.01330-10  0.747
2010 Buchkovich NJ, Maguire TG, Alwine JC. Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infection. Journal of Virology. 84: 7005-17. PMID 20484513 DOI: 10.1128/Jvi.00719-10  0.723
2009 Buchkovich NJ, Maguire TG, Paton AW, Paton JC, Alwine JC. The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the human cytomegalovirus assembly compartment. Journal of Virology. 83: 11421-8. PMID 19741001 DOI: 10.1128/Jvi.00762-09  0.708
2008 Buchkovich NJ, Yu Y, Zampieri CA, Alwine JC. The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway. Nature Reviews. Microbiology. 6: 266-75. PMID 18311165 DOI: 10.1038/Nrmicro1855  0.714
2008 Yu Y, Alwine JC. Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt. Journal of Virology. 82: 4521-6. PMID 18305032 DOI: 10.1128/Jvi.02365-07  0.391
2008 Buchkovich NJ, Maguire TG, Yu Y, Paton AW, Paton JC, Alwine JC. Human cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78, which is required for virion assembly. Journal of Virology. 82: 31-9. PMID 17942541 DOI: 10.1128/Jvi.01881-07  0.757
2007 Kudchodkar SB, Del Prete GQ, Maguire TG, Alwine JC. AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection. Journal of Virology. 81: 3649-51. PMID 17215282 DOI: 10.1128/Jvi.02079-06  0.709
2006 Kudchodkar SB, Yu Y, Maguire TG, Alwine JC. Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. Proceedings of the National Academy of Sciences of the United States of America. 103: 14182-7. PMID 16959881 DOI: 10.1073/Pnas.0605825103  0.722
2006 Yu Y, Alwine JC. 19S late mRNAs of simian virus 40 have an internal ribosome entry site upstream of the virion structural protein 3 coding sequence. Journal of Virology. 80: 6553-8. PMID 16775341 DOI: 10.1128/Jvi.00517-06  0.384
2005 Isler JA, Maguire TG, Alwine JC. Production of infectious human cytomegalovirus virions is inhibited by drugs that disrupt calcium homeostasis in the endoplasmic reticulum. Journal of Virology. 79: 15388-97. PMID 16306610 DOI: 10.1128/Jvi.79.24.15388-15397.2005  0.428
2005 Isler JA, Skalet AH, Alwine JC. Human cytomegalovirus infection activates and regulates the unfolded protein response. Journal of Virology. 79: 6890-9. PMID 15890928 DOI: 10.1128/Jvi.79.11.6890-6899.2005  0.518
2005 Yu Y, Kudchodkar SB, Alwine JC. Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection. Journal of Virology. 79: 6882-9. PMID 15890927 DOI: 10.1128/Jvi.79.11.6882-6889.2005  0.714
2005 Barrasa MI, Harel NY, Alwine JC. The phosphorylation status of the serine-rich region of the human cytomegalovirus 86-kilodalton major immediate-early protein IE2/IEP86 affects temporal viral gene expression. Journal of Virology. 79: 1428-37. PMID 15650169 DOI: 10.1128/Jvi.79.3.1428-1437.2005  0.334
2004 Kudchodkar SB, Yu Y, Maguire TG, Alwine JC. Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase. Journal of Virology. 78: 11030-9. PMID 15452223 DOI: 10.1128/Jvi.78.20.11030-11039.2004  0.703
2004 Awasthi S, Isler JA, Alwine JC. Analysis of splice variants of the immediate-early 1 region of human cytomegalovirus. Journal of Virology. 78: 8191-200. PMID 15254190 DOI: 10.1128/Jvi.78.15.8191-8200.2004  0.456
2003 Barrasa MI, Harel N, Yu Y, Alwine JC. Strain variations in single amino acids of the 86-kilodalton human cytomegalovirus major immediate-early protein (IE2) affect its functional and biochemical properties: implications of dynamic protein conformation. Journal of Virology. 77: 4760-72. PMID 12663783 DOI: 10.1128/Jvi.77.8.4760-4772.2003  0.347
2002 Cooke C, Alwine JC. Characterization of specific protein-RNA complexes associated with the coupling of polyadenylation and last-intron removal. Molecular and Cellular Biology. 22: 4579-86. PMID 12052867 DOI: 10.1128/Mcb.22.13.4579-4586.2002  0.368
2002 Yu Y, Alwine JC. Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt. Journal of Virology. 76: 3731-8. PMID 11907212 DOI: 10.1128/Jvi.76.8.3731-3738.2002  0.431
2002 Heider JA, Yu Y, Shenk T, Alwine JC. Characterization of a human cytomegalovirus with phosphorylation site mutations in the immediate-early 2 protein. Journal of Virology. 76: 928-32. PMID 11752183 DOI: 10.1128/Jvi.76.2.928-932.2002  0.431
2000 Hans H, Alwine JC. Functionally significant secondary structure of the simian virus 40 late polyadenylation signal. Molecular and Cellular Biology. 20: 2926-32. PMID 10733596 DOI: 10.1128/Mcb.20.8.2926-2932.2000  0.33
1999 Cooke C, Hans H, Alwine JC. Utilization of splicing elements and polyadenylation signal elements in the coupling of polyadenylation and last-intron removal. Molecular and Cellular Biology. 19: 4971-9. PMID 10373547 DOI: 10.1128/Mcb.19.7.4971  0.335
1999 Lukac DM, Alwine JC. Effects of Human Cytomegalovirus Major Immediate-Early Proteins in Controlling the Cell Cycle and Inhibiting Apoptosis: Studies with ts13 Cells Journal of Virology. 73: 2825-2831. DOI: 10.1128/Jvi.73.4.2825-2831.1999  0.37
1998 Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. Rna (New York, N.Y.). 4: 1493-9. PMID 9848648 DOI: 10.1017/S1355838298981183  0.351
1998 Damania B, Lieberman P, Alwine JC. Simian virus 40 large T antigen stabilizes the TATA-binding protein- TFIIA complex on the TATA element Molecular and Cellular Biology. 18: 3926-3935. PMID 9632777 DOI: 10.1128/Mcb.18.7.3926  0.335
1998 Harel NY, Alwine JC. Phosphorylation of the human cytomegalovirus 86-kilodalton immediate-early protein IE2. Journal of Virology. 72: 5481-92. PMID 9621004 DOI: 10.1128/Jvi.72.7.5481-5492.1998  0.386
1998 Damania B, Mital R, Alwine JC. Simian virus 40 large T antigen interacts with human TFIIB-related factor and small nuclear RNA-activating protein complex for transcriptional activation of TATA-containing polymerase III promoters Molecular and Cellular Biology. 18: 1331-1338. PMID 9488448 DOI: 10.1128/Mcb.18.3.1331  0.391
1997 Lukac DM, Harel NY, Tanese N, Alwine JC. TAF-like functions of human cytomegalovirus immediate-early proteins. Journal of Virology. 71: 7227-39. PMID 9311796 DOI: 10.1128/Jvi.71.10.7227-7239.1997  0.373
1996 Cooke C, Alwine JC. The cap and the 3' splice site similarly affect polyadenylation efficiency. Molecular and Cellular Biology. 16: 2579-84. PMID 8649365 DOI: 10.1128/Mcb.16.6.2579  0.339
1996 Damania B, Alwine JC. TAF-like function of SV40 large T antigen Genes and Development. 10: 1369-1381. PMID 8647434 DOI: 10.1101/Gad.10.11.1369  0.33
1996 Lutz CS, Murthy KG, Schek N, O'Connor JP, Manley JL, Alwine JC. Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro. Genes & Development. 10: 325-37. PMID 8595883 DOI: 10.1101/Gad.10.3.325  0.377
1994 Lutz CS, Alwine JC. Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signal. Genes & Development. 8: 576-86. PMID 7926751 DOI: 10.1101/Gad.8.5.576  0.388
1994 Lukac DM, Manuppello JR, Alwine JC. Transcriptional activation by the human cytomegalovirus immediate-early proteins: requirements for simple promoter structures and interactions with multiple components of the transcription complex. Journal of Virology. 68: 5184-5193. DOI: 10.1128/Jvi.68.8.5184-5193.1994  0.371
1993 Kim JYH, Gonzalez-Scarano F, Zeichner SL, Alwine JC. Replication of type 1 human immunodeficiency viruses containing linker substitution mutations in the -201 to -130 region of the long terminal repeat Journal of Virology. 67: 1658-1662. PMID 8437235 DOI: 10.1128/Jvi.67.3.1658-1662.1993  0.391
1993 Gruda MC, Zabolotny JM, Xiao JH, Davidson I, Alwine JC. Transcriptional activation by simian virus 40 large T antigen: interactions with multiple components of the transcription complex. Molecular and Cellular Biology. 13: 961-9. PMID 8423815 DOI: 10.1128/Mcb.13.2.961  0.346
1993 Laughlin MA, Zeichner S, Kolson D, Alwine JC, Seshamma T, Pomerantz RJ, Gonzalez-Scarano F. Sodium Butyrate Treatment of Cells Latently Infected with HIV-1 Results in the Expression of Unspliced Viral RNA Virology. 196: 496-505. PMID 8372431 DOI: 10.1006/Viro.1993.1505  0.391
1992 Valsamakis A, Schek N, Alwine JC. Elements upstream of the AAUAAA within the human immunodeficiency virus polyadenylation signal are required for efficient polyadenylation in vitro. Molecular and Cellular Biology. 12: 3699-705. PMID 1508176 DOI: 10.1128/Mcb.12.9.3699  0.361
1992 Schek N, Cooke C, Alwine JC. Definition of the upstream efficiency element of the simian virus 40 late polyadenylation signal by using in vitro analyses. Molecular and Cellular Biology. 12: 5386-93. PMID 1333042 DOI: 10.1128/Mcb.12.12.5386  0.35
1992 Zeichner SL, Hirka G, Andrews PW, Alwine JC. Differentiation-dependent human immunodeficiency virus long terminal repeat regulatory elements active in human teratocarcinoma cells. Journal of Virology. 66: 2268-2273. DOI: 10.1128/Jvi.66.4.2268-2273.1992  0.357
1991 Valsamakis A, Zeichner S, Carswell S, Alwine JC. The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylation. Proceedings of the National Academy of Sciences of the United States of America. 88: 2108-12. PMID 1848693 DOI: 10.1073/Pnas.88.6.2108  0.344
1991 Zeichner SL, Kim JY, Alwine JC. Linker-scanning mutational analysis of the transcriptional activity of the human immunodeficiency virus type 1 long terminal repeat. Journal of Virology. 65: 2436-2444. DOI: 10.1128/Jvi.65.5.2436-2444.1991  0.38
1990 Gallo GJ, Gruda MC, Manuppello JR, Alwine JC. Activity of simian DNA-binding factors is altered in the presence of simian virus 40 (SV40) early proteins: characterization of factors binding to elements involved in activation of the SV40 late promoter. Journal of Virology. 64: 173-184. DOI: 10.1128/Jvi.64.1.173-184.1990  0.348
1989 Carswell S, Alwine JC. Efficiency of utilization of the simian virus 40 late polyadenylation site: effects of upstream sequences. Molecular and Cellular Biology. 9: 4248-58. PMID 2573828 DOI: 10.1128/Mcb.9.10.4248  0.38
1988 Gallo GJ, Gilinger G, Alwine JC. Simian virus 40 T antigen alters the binding characteristics of specific simian DNA-binding factors. Molecular and Cellular Biology. 8: 1648-56. PMID 2837651 DOI: 10.1128/Mcb.8.4.1648  0.357
1985 Sadofsky M, Connelly S, Manley JL, Alwine JC. Identification of a sequence element on the 3' side of AAUAAA which is necessary for simian virus 40 late mRNA 3'-end processing. Molecular and Cellular Biology. 5: 2713-9. PMID 3016512 DOI: 10.1128/Mcb.5.10.2713  0.341
1984 Keller JM, Alwine JC. Activation of the SV40 late promoter: Direct effects of T antigen in the absence of viral DNA replication Cell. 36: 381-389. PMID 6319019 DOI: 10.1016/0092-8674(84)90231-9  0.365
1982 Alwine JC. Hybrid Selection of Small RNAs by Using Simian Virus 40 DNA: Evidence that the Simian Virus 40-Associated Small RNA Is Synthesized by Specific Cleavage from Large Viral Transcripts Journal of Virology. 43: 987-996. DOI: 10.1128/Jvi.43.3.987-996.1982  0.363
1982 Alwine JC. Evidence for simian virus 40 late transcriptional control: mixed infections of wild-type simian virus 40 and a late leader deletion mutant exhibit trans effects on late viral RNA synthesis. Journal of Virology. 42: 798-803. DOI: 10.1128/jvi.42.3.798-803.1982  0.312
1981 Khoury G, Alwine JC, Dhar R, Gruss P, Lai CJ, Segal S, Seif I. Regulation of SV40 gene expression through RNA splicing. Cold Spring Harbor Symposia On Quantitative Biology. 41-54. PMID 6253152 DOI: 10.1101/Sqb.1980.044.01.007  0.614
1980 Alwine JC, Dhar R, Khoury G. A small RNA induced late in simian virus 40 infection can associate with early viral mRNAs. Proceedings of the National Academy of Sciences of the United States of America. 77: 1379-83. PMID 6246491 DOI: 10.1073/Pnas.77.3.1379  0.62
1980 Khoury G, Alwine J, Goldman N, Gruss P, Jay G. New chimeric splice junction in adenovirus type 2-simian virus 40 hybrid viral mRNA. Journal of Virology. 36: 143-151. DOI: 10.1128/Jvi.36.1.143-151.1980  0.669
1977 Alwine JC, Reed SI, Stark GR. Characterization of the Autoregulation of Simian Virus 40 Gene A Journal of Virology. 24: 22-27. DOI: 10.1128/Jvi.24.1.22-27.1977  0.322
1976 Reed SI, Stark GR, Alwine JC. Autoregulation of simian virus 40 gene A by T antigen. Proceedings of the National Academy of Sciences of the United States of America. 73: 3083-7. PMID 184459 DOI: 10.1073/Pnas.73.9.3083  0.362
1974 Alwine JC, Steinhart WL, Hill CW. Transcription of herpes simplex type 1 DNA in nuclei isolated from infected HEp-2 and KB cells. Virology. 60: 302-7. PMID 4366499 DOI: 10.1016/0042-6822(74)90390-0  0.32
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