| Year |
Citation |
Score |
| 2023 |
Wang K, Marciani L, Amidon GL, Smith DE, Sun D. Stochastic Differential Equation-based Mixed Effects Model of the Fluid Volume in the Fasted Stomach in Healthy Adult Human. The Aaps Journal. 25: 76. PMID 37498389 DOI: 10.1208/s12248-023-00840-3 |
0.442 |
|
| 2022 |
Wang K, Li Y, Chen B, Chen H, Smith DE, Sun D, Feng MR, Amidon GL. In Vitro Predictive Dissolution Test Should Be Developed and Recommended as a Bioequivalence Standard for the Immediate-Release Solid Oral Dosage Forms of the Highly Variable Mycophenolate Mofetil. Molecular Pharmaceutics. PMID 35603895 DOI: 10.1021/acs.molpharmaceut.1c00792 |
0.489 |
|
| 2022 |
Hens B, Seegobin N, Bermejo M, Tsume Y, Clear N, McAllister M, Amidon GE, Amidon GL. Dissolution Challenges Associated with the Surface pH of Drug Particles: Integration into Mechanistic Oral Absorption Modeling. The Aaps Journal. 24: 17. PMID 34982285 DOI: 10.1208/s12248-021-00663-0 |
0.643 |
|
| 2021 |
Salehi N, Kuminek G, Al-Gousous J, Sperry DC, Greenwood DE, Waltz NM, Amidon GL, Ziff RM, Amidon GE. Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transport Analysis. Molecular Pharmaceutics. PMID 34428047 DOI: 10.1021/acs.molpharmaceut.1c00262 |
0.314 |
|
| 2021 |
Gonzalez-Alvarez I, Bermejo M, Tsume Y, Ruiz-Picazo A, Gonzalez-Alvarez M, Hens B, Garcia-Arieta A, Amidon GE, Amidon GL. An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products. Pharmaceutics. 13. PMID 33917118 DOI: 10.3390/pharmaceutics13040507 |
0.683 |
|
| 2020 |
Salehi N, Al-Gousous J, Mudie DM, Amidon GL, Ziff RM, Amidon GE. Hierarchical Mass Transfer Analysis of Drug Particle Dissolution, Highlighting the Hydrodynamics, pH, Particle Size and Buffer Effects for Dissolution of Ionizable and non-Ionizable Drugs in a Compendial Dissolution Vessel. Molecular Pharmaceutics. PMID 32886520 DOI: 10.1021/Acs.Molpharmaceut.0C00614 |
0.422 |
|
| 2020 |
Augustijns P, Vertzoni M, Reppas C, Langguth P, Lennernäs H, Abrahamsson B, Hasler WL, Baker JR, Vanuytsel T, Tack J, Corsetti M, Bermejo M, Paixão P, Amidon GL, Hens B. Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: History, methodology and applications. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 105517. PMID 32818656 DOI: 10.1016/J.Ejps.2020.105517 |
0.403 |
|
| 2020 |
Bhatt-Mehta V, Hammoud H, Amidon GL. A proposed pediatric biopharmaceutical classification system for medications for chronic diseases in children. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 152: 105437. PMID 32598914 DOI: 10.1016/J.Ejps.2020.105437 |
0.336 |
|
| 2020 |
Hens B, Bermejo M, Cristofoletti R, Amidon GE, Amidon GL. Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b). Pharmaceutics. 12. PMID 32570975 DOI: 10.3390/Pharmaceutics12060566 |
0.398 |
|
| 2020 |
Sinko PD, Harris S, Salehi N, Meyer PJ, Amidon GL, Amidon GE. Ultra-Thin, Large-Area Membrane Diffusion Cell for pH-Dependent Simultaneous Dissolution and Absorption Studies. Molecular Pharmaceutics. PMID 32501703 DOI: 10.1021/Acs.Molpharmaceut.0C00040 |
0.4 |
|
| 2020 |
Bermejo M, Hens B, Dickens J, Mudie D, Paixão P, Tsume Y, Shedden K, Amidon GL. A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP. Pharmaceutics. 12. PMID 31963448 DOI: 10.3390/Pharmaceutics12010074 |
0.677 |
|
| 2020 |
Paixão P, Kawakami K, Bermejo M, Tsume Y, Silva N, Moribe K, Morais J, Amidon G, Yamashita S. Report from the “3rd International Symposium on BA/BE of Oral Drug Products: Biopharmaceutics meets Galenics” Journal of Drug Delivery Science and Technology. 56: 101274. DOI: 10.1016/J.Jddst.2019.101274 |
0.68 |
|
| 2020 |
Tsume Y, Igawa N, Drelich AJ, Ruan H, Amidon GE, Amidon GL. The in vivo predictive dissolution for immediate release dosage of donepezil and danazol, BCS class IIc drugs, with the GIS and the USP II with biphasic dissolution apparatus Journal of Drug Delivery Science and Technology. 56: 100920. DOI: 10.1016/J.Jddst.2019.01.035 |
0.712 |
|
| 2019 |
Yu A, Koenigsknecht MJ, Hens B, Baker JR, Wen B, Jackson TL, Pai MP, Hasler W, Amidon GL, Sun D. Mechanistic Deconvolution of Oral Absorption Model with Dynamic Gastrointestinal Fluid to Predict Regional Rate and Extent of GI Drug Dissolution. The Aaps Journal. 22: 3. PMID 31712917 DOI: 10.1208/S12248-019-0385-Z |
0.584 |
|
| 2019 |
Amaral Silva D, Al-Gousous J, Davies NM, Bou Chacra N, Webster GK, Lipka E, Amidon G, Löbenberg R. Simulated, biorelevant, clinically relevant or physiologically relevant dissolution media: The hidden role of bicarbonate buffer. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 31195131 DOI: 10.1016/J.Ejpb.2019.06.006 |
0.37 |
|
| 2019 |
Al-Gousous J, Salehi N, Amidon GE, Ziff RM, Langguth P, Amidon GL. Mass transport analysis of bicarbonate buffer: Effect of the CO-HCO hydration-dehydration kinetics in the fluid boundary layer and the apparent effective pKa controlling dissolution of acids and bases. Molecular Pharmaceutics. PMID 31013101 DOI: 10.1021/Acs.Molpharmaceut.9B00187 |
0.38 |
|
| 2019 |
Bermejo M, Kuminek G, Al-Gousous J, Ruiz-Picazo A, Tsume Y, Garcia-Arieta A, González-Alvarez I, Hens B, Amidon GE, Rodriguez-Hornedo N, Amidon GL, Mudie D. Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses. Pharmaceutics. 11. PMID 30884755 DOI: 10.3390/Pharmaceutics11030122 |
0.696 |
|
| 2019 |
Al-Gousous J, Ruan H, Blechar JA, Sun KX, Salehi N, Langguth P, Job NM, Lipka E, Loebenberg R, Bermejo M, Amidon GE, Amidon GL. Mechanistic Analysis and Experimental verification of Bicarbonate-Controlled Enteric Coat Dissolution: Potential in vivo Implications. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 30872012 DOI: 10.1016/J.Ejpb.2019.03.012 |
0.362 |
|
| 2019 |
Baker JR, Dickens JR, Koenigsknecht M, Frances A, Lee AA, Shedden KA, Brasseur JG, Amidon GL, Sun D, Hasler WL. Propagation Characteristics of Fasting Duodeno-Jejunal Contractions in Healthy Controls Measured by Clustered Closely-spaced Manometric Sensors. Journal of Neurogastroenterology and Motility. 25: 100-112. PMID 30646481 DOI: 10.5056/Jnm18112 |
0.425 |
|
| 2018 |
Paixão P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, ... ... Amidon GE, ... ... Amidon GL, et al. Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State. Molecular Pharmaceutics. PMID 30417648 DOI: 10.1021/Acs.Molpharmaceut.8B00736 |
0.746 |
|
| 2018 |
Bermejo M, Paixão P, Hens B, Tsume Y, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden KA, Wen B, Wysocki J, Löbenberg R, Lee A, ... ... Amidon GE, ... ... Amidon GL, et al. Linking the Gastrointestinal Behavior of Ibuprofen with The Systemic Exposure Between and Within Humans - Part 1: Fasted State. Molecular Pharmaceutics. PMID 30372084 DOI: 10.1021/Acs.Molpharmaceut.8B00515 |
0.742 |
|
| 2018 |
Al-Gousous J, Sun KX, McNamara DP, Hens B, Salehi N, Langguth P, Bermejo M, Amidon GE, Amidon GL. Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate-CO Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance. Molecular Pharmaceutics. PMID 30362350 DOI: 10.1021/Acs.Molpharmaceut.8B00783 |
0.323 |
|
| 2018 |
Tsume Y, Patel S, Fotaki N, Bergstrӧm C, Amidon GL, Brasseur JG, Mudie DM, Sun D, Bermejo M, Gao P, Zhu W, Sperry DC, Vertzoni M, Parrott N, Lionberger R, ... ... Amidon GE, et al. In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance. The Aaps Journal. 20: 100. PMID 30191341 DOI: 10.1208/S12248-018-0260-3 |
0.732 |
|
| 2018 |
Hu Y, Epling D, Shi J, Song F, Tsume Y, Zhu HJ, Amidon GL, Smith DE. Effect of Biphenyl Hydrolase-Like (BPHL) Gene Disruption on the Intestinal Stability, Permeability and Absorption of Valacyclovir in Wildtype and Bphl Knockout Mice. Biochemical Pharmacology. PMID 30121252 DOI: 10.1016/J.Bcp.2018.08.018 |
0.633 |
|
| 2018 |
Hens B, Sinko P, Job N, Dean M, Al-Gousous J, Salehi N, Ziff RM, Tsume Y, Bermejo M, Paixão P, Brasseur JG, Yu A, Talattof A, Benninghoff G, Langguth P, ... ... Amidon GE, ... ... Amidon GL, et al. Formulation Predictive Dissolution (fPD) Testing to Advance Oral Drug Product Development: an Introduction to the US FDA Funded '21 Century BA/BE' Project. International Journal of Pharmaceutics. PMID 29944899 DOI: 10.1016/J.Ijpharm.2018.06.050 |
0.795 |
|
| 2018 |
Paixão P, Bermejo M, Hens B, Tsume Y, Dickens J, Shedden K, Salehi N, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Wysocki J, Wen B, Lee A, ... ... Amidon GE, ... ... Amidon GL, et al. Gastric Emptying and Intestinal Appearance of Nonabsorbable Drugs Phenol Red and Paromomycin in Human Subjects: A Multi-Compartment Stomach Approach. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 29857136 DOI: 10.1016/J.Ejpb.2018.05.033 |
0.742 |
|
| 2018 |
Hens B, Talattof A, Paixão P, Bermejo M, Tsume Y, Löbenberg R, Amidon GL. Measuring the Impact of Gastrointestinal Variables on the Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model. The Aaps Journal. 20: 57. PMID 29600330 DOI: 10.1208/S12248-018-0217-6 |
0.638 |
|
| 2018 |
Hens B, Bermejo M, Tsume Y, Gonzalez-Alvarez I, Ruan H, Matsui K, Amidon GE, Cavanagh K, Kuminek G, Benninghoff G, Fan J, Rodríguez-Hornedo N, Amidon GL. Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 29378253 DOI: 10.1016/J.Ejps.2018.01.039 |
0.693 |
|
| 2018 |
Hens B, Al-Gousous J, Wang K, Salehi N, Ziff RM, Tsume Y, Bermejo M, Paixão P, Brasseur JG, Yu A, Talattof A, Benninghoff G, Langguth P, Lennernäs H, Hasler WL, ... ... Amidon GE, ... ... Amidon GL, et al. Summary of the In Vivo Predictive Dissolution (iPD) - Oral Drug Delivery (ODD) Conference 2018 Dissolution Technologies. 25: 50-53. DOI: 10.14227/Dt250218P50 |
0.747 |
|
| 2018 |
Hasler WL, Baker J, Dickens J, Koenigsknecht M, Frances A, Lee A, Shedden K, Harer K, Amidon G, Sun D. Sa1561 - Standardizing Parameters of Fasting Duodenojejunal Manometry in Healthy Volunteers Using Clustered High-Resolution Pressure Ports: Focus on Migrating Motor Complex Phase 2 Contractions Gastroenterology. 154: S-311. DOI: 10.1016/S0016-5085(18)31385-4 |
0.414 |
|
| 2017 |
Sun K, Xu H, Hilfinger JL, Lee KD, Provoda CJ, Sabit H, Amidon GL. Improved Protease-Targeting and Biopharmaceutical Properties of Novel Prodrugs of Ganciclovir. Molecular Pharmaceutics. PMID 29251944 DOI: 10.1021/Acs.Molpharmaceut.7B00792 |
0.726 |
|
| 2017 |
Sinko PD, Gidley D, Vallery R, Lamoureux A, Amidon GL, Amidon GE. In vitro Characterization of the Biomimetic Properties of Poly(dimethyl siloxane) to Simulate Oral Drug Absorption. Molecular Pharmaceutics. PMID 29120190 DOI: 10.1021/Acs.Molpharmaceut.7B00798 |
0.421 |
|
| 2017 |
Cao F, Amidon GL, Rodríguez-Hornedo N, Amidon GE. Mechanistic basis of cocrystal dissolution advantage. Journal of Pharmaceutical Sciences. PMID 28989017 DOI: 10.1016/J.Xphs.2017.09.014 |
0.405 |
|
| 2017 |
Yu A, Jackson T, Tsume Y, Koenigsknecht M, Wysocki J, Marciani L, Amidon GL, Frances A, Baker JR, Hasler W, Wen B, Pai A, Sun D. Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time. The Aaps Journal. PMID 28980204 DOI: 10.1208/S12248-017-0145-X |
0.723 |
|
| 2017 |
Sun D, Baker JR, Wen B, Frances A, Zhang H, Yu A, Zhao T, Tsume Y, Pai M, Bleske B, Zhang X, Lionberger R, Lee A, Amidon G, Hasler WL, et al. In Vivo Dissolution and Systemic Absorption of Immediate Release Ibuprofen in Human Gastrointestinal Tract Under Fed and Fasted Conditions. Molecular Pharmaceutics. PMID 28937221 DOI: 10.1021/Acs.Molpharmaceut.7B00425 |
0.762 |
|
| 2017 |
Tsume Y, Igawa N, Drelich AJ, Amidon GE, Amidon GL. The combination of GIS and biphasic to better predict in vivo dissolution of BCS class IIb drugs, ketoconazole and raloxifene. Journal of Pharmaceutical Sciences. PMID 28919384 DOI: 10.1016/J.Xphs.2017.09.002 |
0.707 |
|
| 2017 |
Tsume Y, Drelich AJ, Smith DE, Amidon GL. Potential Development of Tumor-Targeted Oral Anti-Cancer Prodrugs: Amino Acid and Dipeptide Monoester Prodrugs of Gemcitabine. Molecules (Basel, Switzerland). 22. PMID 28796151 DOI: 10.3390/Molecules22081322 |
0.697 |
|
| 2017 |
Hens B, Tsume Y, Bermejo M, Paixao P, Koenigsknecht M, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden KA, Wen B, Wysocki J, Löbenberg R, Lee A, ... ... Amidon GE, ... ... Amidon GL, et al. Low Buffer Capacity and Alternating Motility Along The Human Gastrointestinal Tract: Implications for In Vivo Dissolution and Absorption of Ionizable Drugs. Molecular Pharmaceutics. PMID 28737409 DOI: 10.1021/Acs.Molpharmaceut.7B00426 |
0.745 |
|
| 2017 |
Murray K, Hoad CL, Mudie DM, Wright J, Heissam K, Abrehart N, Pritchard SE, Al Atwah S, Gowland PA, Garnett MC, Amidon GE, Spiller RC, Amidon GL, Marciani L. Magnetic Resonance Imaging Quantification of Fasted State Colonic Liquid Pockets in Healthy Humans. Molecular Pharmaceutics. PMID 28648070 DOI: 10.1021/Acs.Molpharmaceut.7B00095 |
0.329 |
|
| 2017 |
Tsume Y, Matsui K, Searls AL, Takeuchi S, Amidon GE, Sun D, Amidon GL. The impact of supersaturation level for oral absorption of BCS class IIb drugs, dipyridamole and ketoconazole, using in vivo predictive dissolution system: Gastrointestinal Simulator (GIS). European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 28263914 DOI: 10.1016/J.Ejps.2017.02.042 |
0.77 |
|
| 2017 |
Matsui K, Tsume Y, Takeuchi S, Searls A, Amidon GL. Utilization of Gastrointestinal Simulator (GIS), an in vivo predictive dissolution methodology, coupled with computational approach to forecast oral absorption of dipyridamole. Molecular Pharmaceutics. PMID 28231003 DOI: 10.1021/Acs.Molpharmaceut.6B01063 |
0.712 |
|
| 2017 |
Lennernas H, Lindahl A, Van Peer A, Ollier C, Flanagan T, Lionberger R, Nordmark A, Yamashita S, Yu L, Amidon GL, Fischer V, Sjögren E, Zane P, McAllister M, Abrahamsson B. In Vivo predictive dissolution (IPD) and biopharmaceutical modeling and simulation: future use of modern approaches and methodologies in a regulatory context. Molecular Pharmaceutics. PMID 28195732 DOI: 10.1021/Acs.Molpharmaceut.6B00824 |
0.387 |
|
| 2017 |
Koenigsknecht M, Baker J, Fioritto AF, Tsume Y, Wen B, Dickens J, Yu A, Wysocki J, Shedden K, Bleske B, Lee A, Hasler WL, Amidon G, Sun D. Gastrointestinal Motility and Luminal pH Influence in Vivo Dissolution and Systemic Absorption of Drug Product in Human Gastrointestinal Tract Under Fed and Fasted Conditions Gastroenterology. 152: S206. DOI: 10.1016/S0016-5085(17)30994-0 |
0.74 |
|
| 2017 |
Amidon GL, Tsume Y. Oral product input to the GI tract: GIS an oral product performance technology Frontiers of Chemical Science and Engineering. 11: 516-520. DOI: 10.1007/S11705-017-1658-7 |
0.704 |
|
| 2016 |
Yu A, Baker JR, Fioritto AF, Wang Y, Luo R, Li S, Wen B, Bly M, Tsume Y, Koenigsknecht MJ, Zhang X, Lionberger R, Amidon GL, Hasler WL, Sun D. Measurement of in vivo Gastrointestinal Release and Dissolution of Three Locally Acting Mesalamine Formulations in Regions of the Human Gastrointestinal Tract. Molecular Pharmaceutics. PMID 28009518 DOI: 10.1021/Acs.Molpharmaceut.6B00641 |
0.784 |
|
| 2016 |
Hens B, Corsetti M, Spiller R, Marciani L, Vanuytsel T, Tack J, Talattof A, Amidon GL, Koziolek M, Weitschies W, Wilson CG, Bennink RJ, Brouwers J, Augustijns P. Exploring Gastrointestinal Variables Affecting Drug and Formulation Behavior: Methodologies, Challenges and Opportunities. International Journal of Pharmaceutics. PMID 27915009 DOI: 10.1016/J.Ijpharm.2016.11.063 |
0.373 |
|
| 2016 |
Matsui K, Tsume Y, Amidon GE, Amidon GL. The Evaluation of In Vitro Drug Dissolution of Commercially Available Oral Dosage Forms for Itraconazole in Gastrointestinal Simulator With Biorelevant Media. Journal of Pharmaceutical Sciences. PMID 27020985 DOI: 10.1016/J.Xphs.2016.02.020 |
0.729 |
|
| 2016 |
Cao F, Amidon GL, Rodriguez-Hornedo N, Amidon GE. Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization. Molecular Pharmaceutics. PMID 26877267 DOI: 10.1021/Acs.Molpharmaceut.5B00862 |
0.313 |
|
| 2016 |
Incecayir T, Sun J, Tsume Y, Xu H, Gose T, Nakanishi T, Tamai I, Hilfinger J, Lipka E, Amidon GL. Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue. Journal of Pharmaceutical Sciences. 105: 925-34. PMID 26869437 DOI: 10.1016/J.Xphs.2015.11.036 |
0.743 |
|
| 2016 |
Yu LX, Akseli I, Allen B, Amidon G, Bizjak TG, Boam A, Caulk M, Doleski D, Famulare J, Fisher AC, Furness S, Hasselbalch B, Havel H, Hoag SW, Iser R, et al. Advancing Product Quality: a Summary of the Second FDA/PQRI Conference. The Aaps Journal. PMID 26860627 DOI: 10.1208/S12248-016-9874-5 |
0.734 |
|
| 2016 |
Talattof A, Price JC, Amidon GL. Gastrointestinal Motility Variation and Implications for Plasma Level Variation: Oral Drug Products. Molecular Pharmaceutics. PMID 26692042 DOI: 10.1021/Acs.Molpharmaceut.5B00774 |
0.395 |
|
| 2016 |
Dickens J, Baker J, Lee A, Koenigsknecht M, Fioritto A, Amidon G, Shedden K, Sun D, Hasler W. Discrimination of Fasting and Fed Manometric Gastric and Small Bowel Contraction Morphology in Healthy Humans Using Principal Components Analysis American Journal of Gastroenterology. 111: S460-S461. DOI: 10.14309/00000434-201610001-01059 |
0.457 |
|
| 2016 |
Al-Gousous J, Amidon GL, Langguth P. Toward Biopredictive Dissolution for Enteric Coated Dosage Forms Molecular Pharmaceutics. 13: 1927-1936. DOI: 10.1021/Acs.Molpharmaceut.6B00077 |
0.323 |
|
| 2015 |
Xu H, Majmudar JD, Davda D, Ghanakota P, Kim KH, Carlson HA, Showalter HD, Martin BR, Amidon GL. Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes. Molecular Pharmaceutics. 12: 3399-407. PMID 26262434 DOI: 10.1021/Acs.Molpharmaceut.5B00414 |
0.335 |
|
| 2015 |
Matsui K, Tsume Y, Amidon GE, Amidon GL. In Vitro Dissolution of Fluconazole and Dipyridamole in Gastrointestinal Simulator (GIS), Predicting in Vivo Dissolution and Drug-Drug Interaction Caused by Acid-Reducing Agents. Molecular Pharmaceutics. 12: 2418-28. PMID 25985298 DOI: 10.1021/Acs.Molpharmaceut.5B00135 |
0.722 |
|
| 2015 |
Krieg BJ, Taghavi SM, Amidon GL, Amidon GE. In Vivo Predictive Dissolution: Comparing the Effect of Bicarbonate and Phosphate Buffer on the Dissolution of Weak Acids and Weak Bases. Journal of Pharmaceutical Sciences. PMID 25980464 DOI: 10.1002/Jps.24460 |
0.407 |
|
| 2015 |
Tsume Y, Takeuchi S, Matsui K, Amidon GE, Amidon GL. In vitro dissolution methodology, mini-Gastrointestinal Simulator (mGIS), predicts better in vivo dissolution of a weak base drug, dasatinib. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 76: 203-12. PMID 25978875 DOI: 10.1016/J.Ejps.2015.05.013 |
0.727 |
|
| 2015 |
Ozawa M, Tsume Y, Zur M, Dahan A, Amidon GL. Intestinal permeability study of minoxidil: assessment of minoxidil as a high permeability reference drug for biopharmaceutics classification. Molecular Pharmaceutics. 12: 204-11. PMID 25423288 DOI: 10.1021/Mp500553B |
0.718 |
|
| 2015 |
Matsui K, Tsume Y, Amidon GE, Amidon GL. In Vitro Dissolution of Fluconazole and Dipyridamole in Gastrointestinal Simulator (GIS), Predicting in Vivo Dissolution and Drug-Drug Interaction Caused by Acid-Reducing Agents Molecular Pharmaceutics. 12: 2418-2428. DOI: 10.1021/acs.molpharmaceut.5b00135 |
0.679 |
|
| 2015 |
Tsume Y, Takeuchi S, Matsui K, Amidon GE, Amidon GL. In vitro dissolution methodology, mini-Gastrointestinal Simulator (mGIS), predicts better in vivo dissolution of a weak base drug, dasatinib European Journal of Pharmaceutical Sciences. 76: 203-212. DOI: 10.1016/j.ejps.2015.05.013 |
0.67 |
|
| 2014 |
Dahan A, Wolk O, Yang P, Mittal S, Wu Z, Landowski CP, Amidon GL. Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers. Molecular Pharmaceutics. 11: 4385-94. PMID 25365774 DOI: 10.1021/Mp500483V |
0.745 |
|
| 2014 |
Takeuchi S, Tsume Y, Amidon GE, Amidon GL. Evaluation of a three compartment in vitro gastrointestinal simulator dissolution apparatus to predict in vivo dissolution. Journal of Pharmaceutical Sciences. 103: 3416-22. PMID 25251982 DOI: 10.1002/Jps.24112 |
0.696 |
|
| 2014 |
Walls ZF, Gupta SV, Amidon GL, Lee KD. Synthesis and characterization of valyloxy methoxy luciferin for the detection of valacyclovirase and peptide transporter. Bioorganic & Medicinal Chemistry Letters. 24: 4781-3. PMID 25240255 DOI: 10.1016/J.Bmcl.2014.09.011 |
0.336 |
|
| 2014 |
Krieg BJ, Taghavi SM, Amidon GL, Amidon GE. In vivo predictive dissolution: transport analysis of the CO2 , bicarbonate in vivo buffer system. Journal of Pharmaceutical Sciences. 103: 3473-90. PMID 25212721 DOI: 10.1002/Jps.24108 |
0.394 |
|
| 2014 |
Shah VP, Amidon GL. G.L. Amidon, H. Lennernas, V.P. Shah, and J.R. Crison. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability, Pharm Res 12, 413-420, 1995--backstory of BCS. The Aaps Journal. 16: 894-8. PMID 24961917 DOI: 10.1208/S12248-014-9620-9 |
0.404 |
|
| 2014 |
Dahan A, Wolk O, Zur M, Amidon GL, Abrahamsson B, Cristofoletti R, Groot DW, Kopp S, Langguth P, Polli JE, Shah VP, Dressman JB. Biowaiver monographs for immediate-release solid oral dosage forms: codeine phosphate. Journal of Pharmaceutical Sciences. 103: 1592-600. PMID 24788239 DOI: 10.1002/Jps.23977 |
0.417 |
|
| 2014 |
Zur M, Gasparini M, Wolk O, Amidon GL, Dahan A. The low/high BCS permeability class boundary: physicochemical comparison of metoprolol and labetalol. Molecular Pharmaceutics. 11: 1707-14. PMID 24735251 DOI: 10.1021/Mp500152Y |
0.444 |
|
| 2014 |
Tsume Y, Mudie DM, Langguth P, Amidon GE, Amidon GL. The Biopharmaceutics Classification System: subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 57: 152-63. PMID 24486482 DOI: 10.1016/J.Ejps.2014.01.009 |
0.716 |
|
| 2014 |
Tsume Y, Borras Bermejo B, Amidon GL. The dipeptide monoester prodrugs of floxuridine and gemcitabine-feasibility of orally administrable nucleoside analogs. Pharmaceuticals (Basel, Switzerland). 7: 169-91. PMID 24473270 DOI: 10.3390/Ph7020169 |
0.714 |
|
| 2014 |
Tsume Y, Incecayir T, Song X, Hilfinger JM, Amidon GL. The development of orally administrable gemcitabine prodrugs with D-enantiomer amino acids: enhanced membrane permeability and enzymatic stability. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 86: 514-23. PMID 24361461 DOI: 10.1016/J.Ejpb.2013.12.009 |
0.695 |
|
| 2013 |
Dahan A, Wolk O, Kim YH, Ramachandran C, Crippen GM, Takagi T, Bermejo M, Amidon GL. Purely in silico BCS classification: science based quality standards for the world's drugs. Molecular Pharmaceutics. 10: 4378-90. PMID 24094040 DOI: 10.1021/Mp400485K |
0.413 |
|
| 2013 |
Heinen CA, Reuss S, Amidon GL, Langguth P. Ion pairing with bile salts modulates intestinal permeability and contributes to food-drug interaction of BCS class III compound trospium chloride. Molecular Pharmaceutics. 10: 3989-96. PMID 23750707 DOI: 10.1021/Mp400179V |
0.311 |
|
| 2013 |
Radwan A, Ebert S, Amar A, Münnemann K, Wagner M, Amidon GL, Langguth P. Mechanistic understanding of food effects: water diffusivity in gastrointestinal tract is an important parameter for the prediction of disintegration of solid oral dosage forms. Molecular Pharmaceutics. 10: 2283-90. PMID 23600970 DOI: 10.1021/Mp3006209 |
0.311 |
|
| 2013 |
Sabit H, Dahan A, Sun J, Provoda CJ, Lee KD, Hilfinger JH, Amidon GL. Cytomegalovirus protease targeted prodrug development. Molecular Pharmaceutics. 10: 1417-24. PMID 23485093 DOI: 10.1021/Mp3007067 |
0.741 |
|
| 2013 |
Fong SY, Liu M, Wei H, Löbenberg R, Kanfer I, Lee VH, Amidon GL, Zuo Z. Establishing the pharmaceutical quality of Chinese herbal medicine: a provisional BCS classification. Molecular Pharmaceutics. 10: 1623-43. PMID 23473440 DOI: 10.1021/Mp300502M |
0.318 |
|
| 2013 |
Xu H, Sabit H, Amidon GL, Showalter HD. An improved synthesis of a fluorophosphonate-polyethylene glycol-biotin probe and its use against competitive substrates. Beilstein Journal of Organic Chemistry. 9: 89-96. PMID 23400700 DOI: 10.3762/Bjoc.9.12 |
0.699 |
|
| 2013 |
Incecayir T, Tsume Y, Amidon GL. Comparison of the permeability of metoprolol and labetalol in rat, mouse, and Caco-2 cells: use as a reference standard for BCS classification. Molecular Pharmaceutics. 10: 958-66. PMID 23327720 DOI: 10.1021/Mp300410N |
0.665 |
|
| 2013 |
Gupta D, Varghese Gupta S, Dahan A, Tsume Y, Hilfinger J, Lee KD, Amidon GL. Increasing oral absorption of polar neuraminidase inhibitors: a prodrug transporter approach applied to oseltamivir analogue. Molecular Pharmaceutics. 10: 512-22. PMID 23244438 DOI: 10.1021/Mp300564V |
0.732 |
|
| 2013 |
Tsume Y, Amidon GL, Takeuchi S. Dissolution effect of gastric and intestinal pH fora BCS class II drug, pioglitazone: New in vitro dissolution system to predict in vivo dissolution Journal of Bioequivalence and Bioavailability. 5: 224-227. DOI: 10.4172/Jbb.1000162 |
0.682 |
|
| 2012 |
Tsume Y, Amidon GL. Selection of suitable prodrug candidates for in vivo studies via in vitro studies; the correlation of prodrug stability in between cell culture homogenates and human tissue homogenates. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society For Pharmaceutical Sciences, SociéTé Canadienne Des Sciences Pharmaceutiques. 15: 433-46. PMID 22974791 DOI: 10.18433/J36K6Z |
0.679 |
|
| 2012 |
Mudie DM, Shi Y, Ping H, Gao P, Amidon GL, Amidon GE. Mechanistic analysis of solute transport in an in vitro physiological two-phase dissolution apparatus. Biopharmaceutics & Drug Disposition. 33: 378-402. PMID 22847296 DOI: 10.1002/Bdd.1803 |
0.644 |
|
| 2012 |
Tsume Y, Langguth P, Garcia-Arieta A, Amidon GL. In silico prediction of drug dissolution and absorption with variation in intestinal pH for BCS class II weak acid drugs: ibuprofen and ketoprofen. Biopharmaceutics & Drug Disposition. 33: 366-77. PMID 22815122 DOI: 10.1002/Bdd.1800 |
0.702 |
|
| 2012 |
Radwan A, Amidon GL, Langguth P. Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity. Biopharmaceutics & Drug Disposition. 33: 403-16. PMID 22782559 DOI: 10.1002/Bdd.1798 |
0.38 |
|
| 2012 |
Dahan A, Lennernäs H, Amidon GL. The fraction dose absorbed, in humans, and high jejunal human permeability relationship. Molecular Pharmaceutics. 9: 1847-51. PMID 22524707 DOI: 10.1021/Mp300140H |
0.419 |
|
| 2012 |
Tsume Y, Amidon GL. The feasibility of enzyme targeted activation for amino acid/dipeptide monoester prodrugs of floxuridine; cathepsin D as a potential targeted enzyme. Molecules (Basel, Switzerland). 17: 3672-89. PMID 22450679 DOI: 10.3390/Molecules17043672 |
0.657 |
|
| 2012 |
Waldmann S, Almukainzi M, Bou-Chacra NA, Amidon GL, Lee BJ, Feng J, Kanfer I, Zuo JZ, Wei H, Bolger MB, Löbenberg R. Provisional biopharmaceutical classification of some common herbs used in Western medicine. Molecular Pharmaceutics. 9: 815-22. PMID 22352942 DOI: 10.1021/Mp200162B |
0.34 |
|
| 2011 |
Gupta SV, Gupta D, Sun J, Dahan A, Tsume Y, Hilfinger J, Lee KD, Amidon GL. Enhancing the intestinal membrane permeability of zanamivir: a carrier mediated prodrug approach. Molecular Pharmaceutics. 8: 2358-67. PMID 21905667 DOI: 10.1021/Mp200291X |
0.742 |
|
| 2011 |
Miller JM, Beig A, Krieg BJ, Carr RA, Borchardt TB, Amidon GE, Amidon GL, Dahan A. The solubility-permeability interplay: mechanistic modeling and predictive application of the impact of micellar solubilization on intestinal permeation. Molecular Pharmaceutics. 8: 1848-56. PMID 21800883 DOI: 10.1021/Mp200181V |
0.373 |
|
| 2011 |
Amidon KS, Langguth P, Lennernäs H, Yu L, Amidon GL. Bioequivalence of oral products and the biopharmaceutics classification system: Science, regulation, and public policy Clinical Pharmacology and Therapeutics. 90: 467-470. PMID 21775984 DOI: 10.1038/Clpt.2011.109 |
0.3 |
|
| 2011 |
Tsume Y, Hilfinger JM, Amidon GL. Potential of amino acid/dipeptide monoester prodrugs of floxuridine in facilitating enhanced delivery of active drug to interior sites of tumors: a two-tier monolayer in vitro study. Pharmaceutical Research. 28: 2575-88. PMID 21671137 DOI: 10.1007/S11095-011-0485-7 |
0.687 |
|
| 2011 |
Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX. The BCS, BDDCS, and regulatory guidances. Pharmaceutical Research. 28: 1774-8. PMID 21491148 DOI: 10.1007/S11095-011-0438-1 |
0.458 |
|
| 2011 |
Tsume Y, Provoda CJ, Amidon GL. The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 879: 915-20. PMID 21450537 DOI: 10.1016/J.Jchromb.2011.02.045 |
0.633 |
|
| 2011 |
Sun J, Miller JM, Beig A, Rozen L, Amidon GL, Dahan A. Mechanistic enhancement of the intestinal absorption of drugs containing the polar guanidino functionality. Expert Opinion On Drug Metabolism & Toxicology. 7: 313-23. PMID 21235283 DOI: 10.1517/17425255.2011.550875 |
0.474 |
|
| 2011 |
Dahan A, Tsume Y, Sun J, Miller JM, Amidon GL. Oral Bioavailability of Peptide and Peptidomimetic Drugs Amino Acids, Peptides and Proteins in Organic Chemistry. 4: 277-292. DOI: 10.1002/9783527631827.ch8 |
0.653 |
|
| 2010 |
Sun J, Dahan A, Walls ZF, Lai L, Lee KD, Amidon GL. Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect. Molecular Pharmaceutics. 7: 2362-8. PMID 21028903 DOI: 10.1021/Mp100300K |
0.59 |
|
| 2010 |
Mudie DM, Amidon GL, Amidon GE. Physiological parameters for oral delivery and in vitro testing. Molecular Pharmaceutics. 7: 1388-405. PMID 20822152 DOI: 10.1021/Mp100149J |
0.447 |
|
| 2010 |
Dahan A, Miller JM, Hilfinger JM, Yamashita S, Yu LX, Lennernäs H, Amidon GL. High-permeability criterion for BCS classification: segmental/pH dependent permeability considerations. Molecular Pharmaceutics. 7: 1827-34. PMID 20701326 DOI: 10.1021/Mp100175A |
0.332 |
|
| 2010 |
Dahan A, Amidon GL, Zimmermann EM. Drug targeting strategies for the treatment of inflammatory bowel disease: a mechanistic update. Expert Review of Clinical Immunology. 6: 543-50. PMID 20594127 DOI: 10.1586/Eci.10.30 |
0.376 |
|
| 2010 |
Tsume Y, Amidon GL. The biowaiver extension for BCS class III drugs: the effect of dissolution rate on the bioequivalence of BCS class III immediate-release drugs predicted by computer simulation. Molecular Pharmaceutics. 7: 1235-43. PMID 20557130 DOI: 10.1021/Mp100053Q |
0.714 |
|
| 2010 |
Miller JM, Dahan A, Gupta D, Varghese S, Amidon GL. Enabling the intestinal absorption of highly polar antiviral agents: ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir. Molecular Pharmaceutics. 7: 1223-34. PMID 20536260 DOI: 10.1021/Mp100050D |
0.43 |
|
| 2010 |
Tehler U, Nelson CH, Peterson LW, Provoda CJ, Hilfinger JM, Lee KD, McKenna CE, Amidon GL. Puromycin-sensitive aminopeptidase: an antiviral prodrug activating enzyme. Antiviral Research. 85: 482-9. PMID 19969024 DOI: 10.1016/J.Antiviral.2009.12.003 |
0.593 |
|
| 2010 |
Sun J, Dahan A, Amidon GL. Enhancing the intestinal absorption of molecules containing the polar guanidino functionality: a double-targeted prodrug approach. Journal of Medicinal Chemistry. 53: 624-32. PMID 19957998 DOI: 10.1021/Jm9011559 |
0.436 |
|
| 2010 |
Dahan A, Amidon GL. MRP2 mediated drug-drug interaction: indomethacin increases sulfasalazine absorption in the small intestine, potentially decreasing its colonic targeting. International Journal of Pharmaceutics. 386: 216-20. PMID 19944137 DOI: 10.1016/J.Ijpharm.2009.11.021 |
0.415 |
|
| 2010 |
Jantratid E, Strauch S, Becker C, Dressman JB, Amidon GL, Junginger HE, Kopp S, Midha KK, Shah VP, Stavchansky S, Barends DM. Biowaiver monographs for immediate release solid oral dosage forms: Doxycycline hyclate. Journal of Pharmaceutical Sciences. 99: 1639-53. PMID 19798752 DOI: 10.1002/Jps.21954 |
0.355 |
|
| 2010 |
Dahan A, Amidon GL. Provisional BCS Classification of the Leading Oral Drugs on the Global Market Burger's Medicinal Chemistry and Drug Discovery. 353-366. DOI: 10.1002/0471266949.Bmc162 |
0.437 |
|
| 2009 |
Dahan A, Miller JM, Amidon GL. Prediction of solubility and permeability class membership: provisional BCS classification of the world's top oral drugs. The Aaps Journal. 11: 740-6. PMID 19876745 DOI: 10.1208/S12248-009-9144-X |
0.44 |
|
| 2009 |
Shin HC, Kim HR, Cho HJ, Yi H, Cho SM, Lee DG, Abd El-Aty AM, Kim JS, Sun D, Amidon GL. Comparative gene expression of intestinal metabolizing enzymes. Biopharmaceutics & Drug Disposition. 30: 411-21. PMID 19746353 DOI: 10.1002/Bdd.675 |
0.516 |
|
| 2009 |
Dahan A, Sabit H, Amidon GL. Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 2028-36. PMID 19589874 DOI: 10.1124/Dmd.109.028282 |
0.733 |
|
| 2009 |
Gupta D, Gupta SV, Lee KD, Amidon GL. Chemical and enzymatic stability of amino acid prodrugs containing methoxy, ethoxy and propylene glycol linkers. Molecular Pharmaceutics. 6: 1604-11. PMID 19566080 DOI: 10.1021/Mp900084V |
0.35 |
|
| 2009 |
Dahan A, Amidon GL. Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. American Journal of Physiology. Gastrointestinal and Liver Physiology. 297: G371-7. PMID 19541926 DOI: 10.1152/Ajpgi.00102.2009 |
0.406 |
|
| 2009 |
Foster DR, Gonzales JP, Amidon GL, Welage LS. Intestinal dipeptide absorption is preserved during thermal injury and cytokine treatment. Jpen. Journal of Parenteral and Enteral Nutrition. 33: 520-8. PMID 19443858 DOI: 10.1177/0148607109333002 |
0.305 |
|
| 2009 |
Dahan A, Sabit H, Amidon GL. The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. The Aaps Journal. 11: 205-13. PMID 19319690 DOI: 10.1208/S12248-009-9092-5 |
0.737 |
|
| 2009 |
Miller JM, Dahan A, Gupta D, Varghese S, Amidon GL. Quasi-equilibrium analysis of the ion-pair mediated membrane transport of low-permeability drugs. Journal of Controlled Release : Official Journal of the Controlled Release Society. 137: 31-7. PMID 19264104 DOI: 10.1016/J.Jconrel.2009.02.018 |
0.382 |
|
| 2009 |
Dahan A, Amidon GL. Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: the role of efflux transport in the oral absorption of BCS class III drugs. Molecular Pharmaceutics. 6: 19-28. PMID 19248230 DOI: 10.1021/Mp800088F |
0.394 |
|
| 2009 |
Foster DR, Yee S, Bleske BE, Carver PL, Shea MJ, Menon SS, Ramachandran C, Welage LS, Amidon GL. Lack of interaction between the peptidomimetic substrates captopril and cephradine. Journal of Clinical Pharmacology. 49: 360-7. PMID 19246733 DOI: 10.1177/0091270008329554 |
0.688 |
|
| 2009 |
Sheng JJ, McNamara DP, Amidon GL. Toward an in vivo dissolution methodology: a comparison of phosphate and bicarbonate buffers. Molecular Pharmaceutics. 6: 29-39. PMID 19183104 DOI: 10.1021/Mp800148U |
0.576 |
|
| 2009 |
Foster DR, Landowski CP, Zheng X, Amidon GL, Welage LS. Interferon-gamma increases expression of the di/tri-peptide transporter, h-PEPT1, and dipeptide transport in cultured human intestinal monolayers. Pharmacological Research. 59: 215-20. PMID 19084598 DOI: 10.1016/J.Phrs.2008.11.001 |
0.696 |
|
| 2009 |
Dahan A, Amidon GL. Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein. Pharmaceutical Research. 26: 883-92. PMID 19048359 DOI: 10.1007/S11095-008-9789-7 |
0.371 |
|
| 2009 |
Dahan A, West BT, Amidon GL. Segmental-dependent membrane permeability along the intestine following oral drug administration: Evaluation of a triple single-pass intestinal perfusion (TSPIP) approach in the rat. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 36: 320-9. PMID 19028572 DOI: 10.1016/J.Ejps.2008.10.013 |
0.381 |
|
| 2009 |
Chuasuwan B, Binjesoh V, Polli JE, Zhang H, Amidon GL, Junginger HE, Midha KK, Shah VP, Stavchansky S, Dressman JB, Barends DM. Biowaiver monographs for immediate release solid oral dosage forms: Diclofenac sodium and diclofenac potassium Journal of Pharmaceutical Sciences. 98: 1206-1219. PMID 18752289 DOI: 10.1002/Jps.21525 |
0.388 |
|
| 2009 |
Arnal J, Gonzalez-Alvarez I, Bermejo M, Amidon GL, Junginger HE, Kopp S, Midha KK, Shah VP, Stavchansky S, Dressman JB, Barends DM. Biowaiver monographs for immediate release solid oral dosage forms: aciclovir. Journal of Pharmaceutical Sciences. 97: 5061-73. PMID 18425814 DOI: 10.1002/Jps.21392 |
0.375 |
|
| 2008 |
Tsume Y, Vig BS, Sun J, Landowski CP, Hilfinger JM, Ramachandran C, Amidon GL. Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters. Molecules (Basel, Switzerland). 13: 1441-54. PMID 18719516 DOI: 10.3390/Molecules13071441 |
0.819 |
|
| 2008 |
Polli JE, Abrahamsson BS, Yu LX, Amidon GL, Baldoni JM, Cook JA, Fackler P, Hartauer K, Johnston G, Krill SL, Lipper RA, Malick WA, Shah VP, Sun D, Winkle HN, et al. Summary workshop report: bioequivalence, biopharmaceutics classification system, and beyond. The Aaps Journal. 10: 373-9. PMID 18679807 DOI: 10.1208/S12248-008-9040-9 |
0.526 |
|
| 2008 |
Tsume Y, Hilfinger JM, Amidon GL. Enhanced cancer cell growth inhibition by dipeptide prodrugs of floxuridine: increased transporter affinity and metabolic stability. Molecular Pharmaceutics. 5: 717-27. PMID 18652477 DOI: 10.1021/Mp800008C |
0.687 |
|
| 2008 |
Higaki K, Choe SY, Löbenberg R, Welage LS, Amidon GL. Mechanistic understanding of time-dependent oral absorption based on gastric motor activity in humans. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 70: 313-25. PMID 18434110 DOI: 10.1016/J.Ejpb.2008.02.022 |
0.596 |
|
| 2008 |
Sheng JJ, Sirois PJ, Dressman JB, Amidon GL. Particle diffusional layer thickness in a USP dissolution apparatus II: a combined function of particle size and paddle speed. Journal of Pharmaceutical Sciences. 97: 4815-29. PMID 18314890 DOI: 10.1002/Jps.21345 |
0.437 |
|
| 2008 |
Becker C, Dressman JB, Amidon GL, Junginger HE, Kopp S, Midha KK, Shah VP, Stavchansky S, Barends DM. Biowaiver monographs for immediate release solid oral dosage forms: pyrazinamide. Journal of Pharmaceutical Sciences. 97: 3709-20. PMID 18271031 DOI: 10.1002/Jps.21250 |
0.358 |
|
| 2008 |
Lai L, Xu Z, Zhou J, Lee KD, Amidon GL. Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase. The Journal of Biological Chemistry. 283: 9318-27. PMID 18256025 DOI: 10.1074/Jbc.M709530200 |
0.558 |
|
| 2008 |
Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX. The use of BDDCS in classifying the permeability of marketed drugs. Pharmaceutical Research. 25: 483-8. PMID 18236138 DOI: 10.1007/S11095-007-9523-X |
0.385 |
|
| 2008 |
Tubic-Grozdanis M, Hilfinger JM, Amidon GL, Kim JS, Kijek P, Staubach P, Langguth P. Pharmacokinetics of the CYP 3A substrate simvastatin following administration of delayed versus immediate release oral dosage forms. Pharmaceutical Research. 25: 1591-600. PMID 18213452 DOI: 10.1007/S11095-007-9519-6 |
0.367 |
|
| 2008 |
Granero GE, Amidon GL. Possibility of enterohepatic recycling of ketoprofen in dogs. International Journal of Pharmaceutics. 349: 166-71. PMID 17890028 DOI: 10.1016/J.Ijpharm.2007.08.005 |
0.366 |
|
| 2008 |
Becker C, Dressman JB, Amidon GL, Junginger HE, Kopp S, Midha KK, Shah VP, Stavchansky S, Barends DM. Biowaiver monographs for immediate release solid oral dosage forms: ethambutol dihydrochloride. Journal of Pharmaceutical Sciences. 97: 1350-60. PMID 17879380 DOI: 10.1002/Jps.21061 |
0.363 |
|
| 2007 |
Kim HR, Park SW, Cho HJ, Chae KA, Sung JM, Kim JS, Landowski CP, Sun D, Abd El-Aty AM, Amidon GL, Shin HC. Comparative gene expression profiles of intestinal transporters in mice, rats and humans. Pharmacological Research. 56: 224-36. PMID 17681807 DOI: 10.1016/J.Phrs.2007.06.005 |
0.738 |
|
| 2007 |
Mittal S, Tsume Y, Landowski CP, Lee KD, Hilfinger JM, Amidon GL. Proline prodrug of melphalan, prophalan-L, demonstrates high therapeutic index in a murine melanoma model. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 67: 752-8. PMID 17560100 DOI: 10.1016/J.Ejpb.2007.03.024 |
0.783 |
|
| 2007 |
Mittal S, Song X, Vig BS, Amidon GL. Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma. Pharmaceutical Research. 24: 1290-8. PMID 17377743 DOI: 10.1007/S11095-007-9249-9 |
0.56 |
|
| 2007 |
Fujii Y, Takahashi M, Morita H, Kikuchi H, Aramaki Y, Amidon GL. Characteristics of gastrointestinal absorption of DX-9065a, a new synthetic anticoagulant. Drug Metabolism and Pharmacokinetics. 22: 26-32. PMID 17329908 DOI: 10.2133/Dmpk.22.26 |
0.354 |
|
| 2007 |
Becker C, Dressman JB, Amidon GL, Junginger HE, Kopp S, Midha KK, Shah VP, Stavchansky S, Barends DM. Biowaiver monographs for immediate release solid oral dosage forms: isoniazid. Journal of Pharmaceutical Sciences. 96: 522-31. PMID 17117431 DOI: 10.1002/Jps.20765 |
0.38 |
|
| 2006 |
Kim JS, Mitchell S, Kijek P, Tsume Y, Hilfinger J, Amidon GL. The suitability of an in situ perfusion model for permeability determinations: utility for BCS class I biowaiver requests. Molecular Pharmaceutics. 3: 686-94. PMID 17140256 DOI: 10.1021/Mp060042F |
0.704 |
|
| 2006 |
Takagi T, Ramachandran C, Bermejo M, Yamashita S, Yu LX, Amidon GL. A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain, and Japan. Molecular Pharmaceutics. 3: 631-43. PMID 17140251 DOI: 10.1021/Mp0600182 |
0.435 |
|
| 2006 |
Sheng JJ, Kasim NA, Chandrasekharan R, Amidon GL. Solubilization and dissolution of insoluble weak acid, ketoprofen: effects of pH combined with surfactant. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 29: 306-14. PMID 16982177 DOI: 10.1016/J.Ejps.2006.06.006 |
0.558 |
|
| 2006 |
Granero GE, Ramachandran C, Amidon GL. Rapid in vivo dissolution of ketoprofen: Implications on the biopharmaceutics classification system Pharmazie. 61: 673-676. PMID 16964708 |
0.35 |
|
| 2006 |
Cao X, Gibbs ST, Fang L, Miller HA, Landowski CP, Shin HC, Lennernas H, Zhong Y, Amidon GL, Yu LX, Sun D. Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharmaceutical Research. 23: 1675-86. PMID 16841194 DOI: 10.1007/S11095-006-9041-2 |
0.773 |
|
| 2006 |
Granero GE, Amidon GL. Stability of valacyclovir: implications for its oral bioavailability. International Journal of Pharmaceutics. 317: 14-8. PMID 16759825 DOI: 10.1016/J.Ijpharm.2006.01.050 |
0.362 |
|
| 2006 |
Jantratid E, Prakongpan S, Amidon GL, Dressman JB. Feasibility of biowaiver extension to biopharmaceutics classification system class III drug products: cimetidine. Clinical Pharmacokinetics. 45: 385-99. PMID 16584285 DOI: 10.2165/00003088-200645040-00004 |
0.415 |
|
| 2006 |
Lorenzi PL, Landowski CP, Brancale A, Song X, Townsend LB, Drach JC, Amidon GL. N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1070-7. PMID 16565170 DOI: 10.1124/Dmd.105.009209 |
0.743 |
|
| 2006 |
Manzo RH, Olivera ME, Amidon GL, Shah VP, Dressman JB, Barends DM. Biowaiver monographs for immediate release solid oral dosage forms: amitriptyline hydrochloride. Journal of Pharmaceutical Sciences. 95: 966-73. PMID 16557529 DOI: 10.1002/Jps.20615 |
0.333 |
|
| 2006 |
Jantratid E, Prakongpan S, Dressman JB, Amidon GL, Junginger HE, Midha KK, Barends DM. Biowaiver monographs for immediate release solid oral dosage forms: cimetidine. Journal of Pharmaceutical Sciences. 95: 974-84. PMID 16557528 DOI: 10.1002/Jps.20614 |
0.35 |
|
| 2006 |
Shin HC, Kim JS, Vig BS, Song X, Drach JC, Amidon GL. Interaction of intestinal nucleoside transporter hCNT2 with amino acid ester prodrugs of floxuridine and 2-bromo-5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. Biological & Pharmaceutical Bulletin. 29: 247-52. PMID 16462026 DOI: 10.1248/Bpb.29.247 |
0.373 |
|
| 2006 |
Kalantzi L, Reppas C, Dressman JB, Amidon GL, Junginger HE, Midha KK, Shah VP, Stavchansky SA, Barends DM. Biowaiver monographs for immediate release solid oral dosage forms: Acetaminophen (Paracetamol) Journal of Pharmaceutical Sciences. 95: 4-14. PMID 16307451 DOI: 10.1002/Jps.20477 |
0.39 |
|
| 2006 |
Lipka E, Spahn-Langguth H, Mutschler E, Amidon GL. In vivo non-linear intestinal permeability of celiprolol and propranolol in conscious dogs: evidence for intestinal secretion. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 6: 75-81. PMID 16256710 DOI: 10.1016/S0928-0987(97)00070-5 |
0.375 |
|
| 2006 |
Landowski CP, Lorenzi PL, Song X, Amidon GL. Nucleoside ester prodrug substrate specificity of liver carboxylesterase. The Journal of Pharmacology and Experimental Therapeutics. 316: 572-80. PMID 16223870 DOI: 10.1124/Jpet.105.092726 |
0.756 |
|
| 2005 |
Granero GE, Ramachandran C, Amidon GL. Dissolution and solubility behavior of fenofibrate in sodium lauryl sulfate solutions. Drug Development and Industrial Pharmacy. 31: 917-22. PMID 16306004 DOI: 10.1080/03639040500272108 |
0.338 |
|
| 2005 |
Landowski CP, Song X, Lorenzi PL, Hilfinger JM, Amidon GL. Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolism. Pharmaceutical Research. 22: 1510-8. PMID 16132363 DOI: 10.1007/S11095-005-6156-9 |
0.783 |
|
| 2005 |
Cao X, Yu LX, Barbaciru C, Landowski CP, Shin HC, Gibbs S, Miller HA, Amidon GL, Sun D. Permeability dominates in vivo intestinal absorption of P-gp substrate with high solubility and high permeability. Molecular Pharmaceutics. 2: 329-40. PMID 16053336 DOI: 10.1021/Mp0499104 |
0.757 |
|
| 2005 |
Lorenzi PL, Landowski CP, Song X, Borysko KZ, Breitenbach JM, Kim JS, Hilfinger JM, Townsend LB, Drach JC, Amidon GL. Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 314: 883-90. PMID 15901797 DOI: 10.1124/Jpet.104.082412 |
0.777 |
|
| 2005 |
Löbenberg R, Kim JS, Amidon GL. Pharmacokinetics of an immediate release, a controlled release and a two pulse dosage form in dogs. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 60: 17-23. PMID 15848051 DOI: 10.1016/J.Ejpb.2004.11.010 |
0.402 |
|
| 2005 |
Landowski CP, Vig BS, Song X, Amidon GL. Targeted delivery to PEPT1-overexpressing cells: acidic, basic, and secondary floxuridine amino acid ester prodrugs. Molecular Cancer Therapeutics. 4: 659-67. PMID 15827340 DOI: 10.1158/1535-7163.Mct-04-0290 |
0.725 |
|
| 2005 |
Song X, Lorenzi PL, Landowski CP, Vig BS, Hilfinger JM, Amidon GL. Amino acid ester prodrugs of the anticancer agent gemcitabine: synthesis, bioconversion, metabolic bioevasion, and hPEPT1-mediated transport. Molecular Pharmaceutics. 2: 157-67. PMID 15804190 DOI: 10.1021/Mp049888E |
0.79 |
|
| 2005 |
Mittal S, Song X, Vig BS, Landowski CP, Kim I, Hilfinger JM, Amidon GL. Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs. Molecular Pharmaceutics. 2: 37-46. PMID 15804176 DOI: 10.1021/Mp049922P |
0.785 |
|
| 2005 |
Song X, Vig BS, Lorenzi PL, Drach JC, Townsend LB, Amidon GL. Amino acid ester prodrugs of the antiviral agent 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole as potential substrates of hPEPT1 transporter. Journal of Medicinal Chemistry. 48: 1274-7. PMID 15715497 DOI: 10.1021/Jm049450I |
0.613 |
|
| 2004 |
Kim I, Crippen GM, Amidon GL. Structure and specificity of a human valacyclovir activating enzyme: a homology model of BPHL. Molecular Pharmaceutics. 1: 434-46. PMID 16028355 DOI: 10.1021/Mp049959+ |
0.554 |
|
| 2004 |
Kim I, Song X, Vig BS, Mittal S, Shin HC, Lorenzi PJ, Amidon GL. A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein. Molecular Pharmaceutics. 1: 117-27. PMID 15832508 DOI: 10.1021/Mp0499757 |
0.669 |
|
| 2004 |
Kasim NA, Whitehouse M, Ramachandran C, Bermejo M, Lennernäs H, Hussain AS, Junginger HE, Stavchansky SA, Midha KK, Shah VP, Amidon GL. Molecular properties of WHO essential drugs and provisional biopharmaceutical classification. Molecular Pharmaceutics. 1: 85-96. PMID 15832504 DOI: 10.1021/Mp034006H |
0.424 |
|
| 2004 |
Faria TN, Timoszyk JK, Stouch TR, Vig BS, Landowski CP, Amidon GL, Weaver CD, Wall DA, Smith RL. A novel high-throughput pepT1 transporter assay differentiates between substrates and antagonists. Molecular Pharmaceutics. 1: 67-76. PMID 15832502 DOI: 10.1021/Mp034001K |
0.702 |
|
| 2004 |
Landowski CP, Anderle P, Sun D, Sadee W, Amidon GL. Transporter and ion channel gene expression after Caco-2 cell differentiation using 2 different microarray technologies. The Aaps Journal. 6: e21. PMID 15760106 DOI: 10.1208/Aapsj060321 |
0.712 |
|
| 2004 |
Balakrishnan A, Rege BD, Amidon GL, Polli JE. Surfactant-mediated dissolution: contributions of solubility enhancement and relatively low micelle diffusivity. Journal of Pharmaceutical Sciences. 93: 2064-75. PMID 15236455 DOI: 10.1002/Jps.20118 |
0.356 |
|
| 2004 |
Delaney B, Stevens LA, Schmelzer W, Haworth J, McCurry S, Hilfinger JM, Kim JS, Tsume Y, Amidon GL, Kritchevsky D. Oral absorption of phytosterols and emulsified phytosterols by Sprague-Dawley rats. The Journal of Nutritional Biochemistry. 15: 289-95. PMID 15135153 DOI: 10.1016/J.Jnutbio.2003.08.013 |
0.663 |
|
| 2004 |
Sun D, Yu LX, Hussain MA, Wall DA, Smith RL, Amidon GL. In vitro testing of drug absorption for drug 'developability' assessment: forming an interface between in vitro preclinical data and clinical outcome. Current Opinion in Drug Discovery & Development. 7: 75-85. PMID 14982151 |
0.529 |
|
| 2004 |
Yu LX, Carlin AS, Amidon GL, Hussain AS. Feasibility studies of utilizing disk intrinsic dissolution rate to classify drugs. International Journal of Pharmaceutics. 270: 221-7. PMID 14726137 DOI: 10.1016/J.Ijpharm.2003.10.016 |
0.39 |
|
| 2004 |
Amidon GL. Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability Edited by H. van de Waterbeemd, H. Lennemas, and P. Artursson. Wiley-VCH, Weinheim, Germany. 2003. xvii + 579 pp. 18 × 24.5 cm. ISBN 3-527-30438-X. $195.00. Journal of Medicinal Chemistry. 47: 1868-1868. DOI: 10.1021/Jm040011T |
0.323 |
|
| 2003 |
Landowski CP, Han HK, Lee KD, Amidon GL. A fluorescent hPept1 transporter substrate for uptake screening. Pharmaceutical Research. 20: 1738-45. PMID 14661916 DOI: 10.1023/B:Pham.0000003369.64891.51 |
0.693 |
|
| 2003 |
Vig BS, Lorenzi PJ, Mittal S, Landowski CP, Shin HC, Mosberg HI, Hilfinger JM, Amidon GL. Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis. Pharmaceutical Research. 20: 1381-8. PMID 14567631 DOI: 10.1023/A:1025745824632 |
0.75 |
|
| 2003 |
Panyam J, Dali MM, Sahoo SK, Ma W, Chakravarthi SS, Amidon GL, Levy RJ, Labhasetwar V. Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 92: 173-87. PMID 14499195 DOI: 10.1016/S0168-3659(03)00328-6 |
0.475 |
|
| 2003 |
Shin HC, Landowski CP, Sun D, Vig BS, Kim I, Mittal S, Lane M, Rosania G, Drach JC, Amidon GL. Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. Biochemical and Biophysical Research Communications. 307: 696-703. PMID 12893280 DOI: 10.1016/S0006-291X(03)01259-2 |
0.812 |
|
| 2003 |
Chiu YY, Higaki K, Neudeck BL, Barnett JL, Welage LS, Amidon GL. Human jejunal permeability of cyclosporin A: influence of surfactants on P-glycoprotein efflux in Caco-2 cells. Pharmaceutical Research. 20: 749-56. PMID 12751630 DOI: 10.1023/A:1023481418576 |
0.406 |
|
| 2003 |
Landowski CP, Sun D, Foster DR, Menon SS, Barnett JL, Welage LS, Ramachandran C, Amidon GL. Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parameters. The Journal of Pharmacology and Experimental Therapeutics. 306: 778-86. PMID 12750437 DOI: 10.1124/Jpet.103.051011 |
0.807 |
|
| 2003 |
Kim I, Chu XY, Kim S, Provoda CJ, Lee KD, Amidon GL. Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase. The Journal of Biological Chemistry. 278: 25348-56. PMID 12732646 DOI: 10.1074/Jbc.M302055200 |
0.587 |
|
| 2003 |
Tamura S, Tokunaga Y, Ibuki R, Amidon GL, Sezaki H, Yamashita S. The site-specific transport and metabolism of tacrolimus in rat small intestine. The Journal of Pharmacology and Experimental Therapeutics. 306: 310-6. PMID 12676880 DOI: 10.1124/Jpet.103.050716 |
0.347 |
|
| 2003 |
Saito G, Amidon GL, Lee KD. Enhanced cytosolic delivery of plasmid DNA by a sulfhydryl-activatable listeriolysin O/protamine conjugate utilizing cellular reducing potential. Gene Therapy. 10: 72-83. PMID 12525839 DOI: 10.1038/sj.gt.3301859 |
0.49 |
|
| 2002 |
Oh DM, Han HK, Williamson RM, Bigge CF, Amidon GL, Stewart BH, Surendran N. Improved intestinal transport of PD 158473, an N-methyl-D-aspartate (NMDA) antagonist, by involvement of multiple transporters. Journal of Pharmaceutical Sciences. 91: 2579-87. PMID 12434401 DOI: 10.1002/Jps.10241 |
0.363 |
|
| 2002 |
Sun D, Lennernas H, Welage LS, Barnett JL, Landowski CP, Foster D, Fleisher D, Lee KD, Amidon GL. Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs. Pharmaceutical Research. 19: 1400-16. PMID 12425456 DOI: 10.1023/A:1020483911355 |
0.765 |
|
| 2002 |
Su SF, Amidon GL, Lee HJ. Possible degradative process of cholecystokinin analogs in rabbit jejunum brush-border membrane vesicles. Life Sciences. 72: 35-47. PMID 12409143 DOI: 10.1016/S0024-3205(02)02198-7 |
0.346 |
|
| 2002 |
Martinez M, Amidon G, Clarke L, Jones WW, Mitra A, Riviere J. Applying the biopharmaceutics classification system to veterinary pharmaceutical products. Part II. Physiological considerations. Advanced Drug Delivery Reviews. 54: 825-50. PMID 12363433 DOI: 10.1016/S0169-409X(02)00071-6 |
0.422 |
|
| 2002 |
Yu LX, Amidon GL, Polli JE, Zhao H, Mehta MU, Conner DP, Shah VP, Lesko LJ, Chen ML, Lee VH, Hussain AS. Biopharmaceutics classification system: the scientific basis for biowaiver extensions. Pharmaceutical Research. 19: 921-5. PMID 12180542 DOI: 10.1023/A:1016473601633 |
0.394 |
|
| 2002 |
Martinez MN, Amidon GL. A mechanistic approach to understanding the factors affecting drug absorption: a review of fundamentals. Journal of Clinical Pharmacology. 42: 620-43. PMID 12043951 DOI: 10.1177/00970002042006005 |
0.437 |
|
| 2002 |
Lee HJ, Amidon GL. The effect of enzyme inhibitor and absorption site following [D-ala2, D-leu5]enkephalin oral administration in rats. Biopharmaceutics & Drug Disposition. 23: 131-41. PMID 12015787 DOI: 10.1002/Bdd.302 |
0.329 |
|
| 2002 |
Li LY, Amidon GL, Kim JS, Heimbach T, Kesisoglou F, Topliss JT, Fleisher D. Intestinal metabolism promotes regional differences in apical uptake of indinavir: coupled effect of P-glycoprotein and cytochrome P450 3A on indinavir membrane permeability in rat. The Journal of Pharmacology and Experimental Therapeutics. 301: 586-93. PMID 11961060 DOI: 10.1124/Jpet.301.2.586 |
0.352 |
|
| 2002 |
Lennernäs H, Knutson L, Knutson T, Hussain A, Lesko L, Salmonson T, Amidon GL. The effect of amiloride on the in vivo effective permeability of amoxicillin in human jejunum: experience from a regional perfusion technique. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 15: 271-7. PMID 11923059 DOI: 10.1016/S0928-0987(02)00005-2 |
0.374 |
|
| 2002 |
Su SF, Amidon GL, Lee HJ. Intestinal metabolism and absorption of cholecystokinin analogs in rats. Biochemical and Biophysical Research Communications. 292: 632-8. PMID 11922613 DOI: 10.1006/Bbrc.2002.6718 |
0.386 |
|
| 2002 |
Tamura S, Ohike A, Ibuki R, Amidon GL, Yamashita S. Tacrolimus is a class II low-solubility high-permeability drug: the effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats. Journal of Pharmaceutical Sciences. 91: 719-29. PMID 11920757 DOI: 10.1002/Jps.10041 |
0.363 |
|
| 2002 |
Takamatsu N, Welage LS, Hayashi Y, Yamamoto R, Barnett JL, Shah VP, Lesko LJ, Ramachandran C, Amidon GL. Variability in cimetidine absorption and plasma double peaks following oral administration in the fasted state in humans: correlation with antral gastric motility. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 53: 37-47. PMID 11777751 DOI: 10.1016/S0939-6411(01)00207-7 |
0.312 |
|
| 2002 |
Botka CW, Wittig TW, Graul RC, Nielsen CU, Higaka K, Amidon GL, Sadée W. Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. Aaps Pharmsci. 2: E16. PMID 11741232 DOI: 10.1208/Ps020216 |
0.31 |
|
| 2002 |
Takamatsu N, Welage LS, Hayashi Y, Yamamoto R, Barnett JL, Shah VP, Lesko LJ, Ramachandran C, Amidon GL. Corrigendum to “Variability in cimetidine absorption and plasma double peaks following oral administration in the fasted state in humans: correlation with antral gastric motility” [Eur. J. Pharm. Biopharm. 53 (2002) 37–47] European Journal of Pharmaceutics and Biopharmaceutics. 54: 255. DOI: 10.1016/S0939-6411(02)00058-9 |
0.308 |
|
| 2001 |
Sun D, Landowski CP, Chu X, Wallsten R, Komorowski TE, Fleisher D, Amidon GL. Drug inhibition of Gly-Sar uptake and hPepT1 localization using hPepT1-GFP fusion protein. Aaps Pharmsci. 3: E2. PMID 11741253 DOI: 10.1208/Ps030102 |
0.739 |
|
| 2001 |
Choe SY, Neudeck BL, Welage LS, Amidon GE, Barnett JL, Amidon GL. Novel method to assess gastric emptying in humans: the Pellet Gastric Emptying Test. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 14: 347-53. PMID 11684410 DOI: 10.1016/S0928-0987(01)00196-8 |
0.6 |
|
| 2001 |
Takamatsu N, Kim ON, Welage LS, Idkaidek NM, Hayashi Y, Barnett J, Yamamoto R, Lipka E, Lennernäs H, Hussain A, Lesko L, Amidon GL. Human jejunal permeability of two polar drugs: cimetidine and ranitidine. Pharmaceutical Research. 18: 742-4. PMID 11474776 DOI: 10.1023/A:1011020025338 |
0.384 |
|
| 2001 |
Higaki K, Yamashita S, Amidon GL. Time-dependent oral absorption models Journal of Pharmacokinetics and Pharmacodynamics. 28: 109-128. PMID 11381566 DOI: 10.1023/A:1011573831444 |
0.333 |
|
| 2000 |
Han HK, Amidon GL. Targeted prodrug design to optimize drug delivery Aaps Pharmsci [Electronic Resource]. 2. PMID 11741222 DOI: 10.1208/Ps020106 |
0.393 |
|
| 2000 |
Ezra A, Hoffman A, Breuer E, Alferiev IS, Mönkkönen J, El Hanany-Rozen N, Weiss G, Stepensky D, Gati I, Cohen H, Törmälehto S, Amidon GL, Golomb G. A peptide prodrug approach for improving bisphosphonate oral absorption Journal of Medicinal Chemistry. 43: 3641-3652. PMID 11020278 DOI: 10.1021/Jm980645Y |
0.431 |
|
| 2000 |
Löbenberg R, Krämer J, Shah VP, Amidon GL, Dressman JB. Dissolution testing as a prognostic tool for oral drug absorption: dissolution behavior of glibenclamide. Pharmaceutical Research. 17: 439-44. PMID 10870988 DOI: 10.1023/A:1007529020774 |
0.344 |
|
| 2000 |
Löbenberg R, Amidon GL. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards European Journal of Pharmaceutics and Biopharmaceutics. 50: 3-12. PMID 10840189 DOI: 10.1016/S0939-6411(00)00091-6 |
0.404 |
|
| 2000 |
Desai MP, Hilfinger JM, Amidon GL, Levy RJ, Labhasetwar V. Immune response with biodegradable nanospheres and alum: Studies in rabbits using staphylococcal enterotoxin B-toxoid Journal of Microencapsulation. 17: 215-225. PMID 10738697 DOI: 10.1080/026520400288454 |
0.463 |
|
| 2000 |
Jinno J, Oh DM, Crison JR, Amidon GL. Dissolution of ionizable water-insoluble drugs: The combined effect of pH and surfactant Journal of Pharmaceutical Sciences. 89: 268-274. PMID 10688756 DOI: 10.1002/(Sici)1520-6017(200002)89:2<268::Aid-Jps14>3.0.Co;2-F |
0.37 |
|
| 2000 |
Hilgendorf C, Spahn-Langguth H, Regårdh CG, Lipka E, Amidon GL, Langguth P. Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: permeabilities via diffusion, inside- and outside-directed carrier-mediated transport. Journal of Pharmaceutical Sciences. 89: 63-75. PMID 10664539 DOI: 10.1002/(Sici)1520-6017(200001)89:1<63::Aid-Jps7>3.0.Co;2-6 |
0.314 |
|
| 2000 |
Amidon GL. Dissolution studies as surrogate for bioequivalence European Journal of Drug Metabolism and Pharmacokinetics. 25: 65-65. DOI: 10.1007/Bf03190063 |
0.315 |
|
| 1999 |
Hsu CP, Walter E, Merkle HP, Rothen-Rutishauser B, Wunderli-Allenspach H, Hilfinger JM, Amidon GL. Function and immunolocalization of overexpressed human intestinal H+/peptide cotransporter in adenovirus-transduced Caco-2 cells. Aaps Pharmsci. 1: E12. PMID 11741208 DOI: 10.1208/Ps010312 |
0.303 |
|
| 1999 |
Oh DM, Han HK, Amidon GL. Drug transport and targeting. Intestinal transport Pharmaceutical Biotechnology. 12: 59-88. PMID 10742972 DOI: 10.1007/0-306-46812-3_3 |
0.407 |
|
| 1999 |
Oh DM, Amidon GL. Overview of membrane transport Pharmaceutical Biotechnology. 12: 1-27. PMID 10742970 DOI: 10.1007/0-306-46812-3_1 |
0.418 |
|
| 1999 |
Lipka E, Amidon GL. Setting bioequivalence requirements for drug development based on preclinical data: Optimizing oral drug delivery systems Journal of Controlled Release. 62: 41-49. PMID 10518633 DOI: 10.1016/S0168-3659(99)00022-X |
0.433 |
|
| 1999 |
Markland P, Zhang Y, Amidon GL, Yang VC. A pH- and ionic strength-responsive polypeptide hydrogel: Synthesis, characterization, and preliminary protein release studies Journal of Biomedical Materials Research. 47: 595-602. PMID 10497296 DOI: 10.1002/(Sici)1097-4636(19991215)47:4<595::Aid-Jbm17>3.0.Co;2-I |
0.307 |
|
| 1999 |
Yu LX, Amidon GL. A compartmental absorption and transit model for estimating oral drug absorption International Journal of Pharmaceutics. 186: 119-125. PMID 10486429 DOI: 10.1016/S0378-5173(99)00147-7 |
0.424 |
|
| 1999 |
Markland P, Amidon GL, Yang VC. Modified polypeptides containing γ-benzyl glutamic acid as drug delivery platforms International Journal of Pharmaceutics. 178: 183-192. PMID 10205638 DOI: 10.1016/S0378-5173(98)00373-1 |
0.347 |
|
| 1999 |
Kaus LC, Gillespie WR, Hussain AS, Amidon GL. The effect of in vivo dissolution, gastric emptying rate, and intestinal transit time on the peak concentration and area-under-the-curve of drugs with different gastrointestinal permeabilities. Pharmaceutical Research. 16: 272-80. PMID 10100314 DOI: 10.1023/A:1018836727001 |
0.376 |
|
| 1999 |
Han HK, Rhie JK, Oh DM, Saito G, Hsu CP, Stewart BH, Amidon GL. CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs. Journal of Pharmaceutical Sciences. 88: 347-50. PMID 10052994 DOI: 10.1021/Js980132E |
0.629 |
|
| 1999 |
Taki Y, Sakane T, Nadai T, Sezaki H, Amidon GL, Langguth P, Yamashita S. First-pass metabolism of peptide drugs in rat perfused liver. The Journal of Pharmacy and Pharmacology. 50: 1013-8. PMID 9811162 DOI: 10.1111/J.2042-7158.1998.Tb06916.X |
0.331 |
|
| 1999 |
Pang DC, Amidon GL, Preusch PC, Sadee W. Meeting report. Second AAPS-NIH frontier symposium 1999: Membrane transporters and drug therapy Aaps Pharmsci. 1: XI-XII. DOI: 10.1208/Ps010205 |
0.354 |
|
| 1998 |
Axelrod HR, Kim JS, Longley CB, Lipka E, Amidon GL, Kakarla R, Hui YW, Weber SJ, Choe S, Sofia MJ. Intestinal transport of gentamicin with a novel, glycosteroid drug transport agent Pharmaceutical Research. 15: 1876-1881. PMID 9892472 DOI: 10.1023/A:1011962207882 |
0.647 |
|
| 1998 |
Covitz KM, Amidon GL, Sadée W. Membrane topology of the human dipeptide transporter, hPEPT1, determined by epitope insertions. Biochemistry. 37: 15214-21. PMID 9790685 DOI: 10.1021/Bi981128K |
0.319 |
|
| 1998 |
Han HK, Oh DM, Amidon GL. Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter Pharmaceutical Research. 15: 1382-1386. PMID 9755889 DOI: 10.1023/A:1011945420235 |
0.421 |
|
| 1998 |
Hsu CP, Hilfinger JM, Walter E, Merkle HP, Roessler BJ, Amidon GL. Overexpression of human intestinal oligopeptide transporter in mammalian cells via adenoviral transduction. Pharmaceutical Research. 15: 1376-81. PMID 9755888 DOI: 10.1023/A:1011993303397 |
0.395 |
|
| 1998 |
Croyle MA, Roessler BJ, Hsu CP, Sun R, Amidon GL. Beta cyclodextrins enhance adenoviral-mediated gene delivery to the intestine. Pharmaceutical Research. 15: 1348-55. PMID 9755884 DOI: 10.1023/A:1011985101580 |
0.326 |
|
| 1998 |
Croyle MA, Anderson DJ, Roessler BJ, Amidon GL. Development of a highly efficient purification process for recombinant adenoviral vectors for oral gene delivery. Pharmaceutical Development and Technology. 3: 365-72. PMID 9742557 DOI: 10.3109/10837459809009864 |
0.308 |
|
| 1998 |
Han H, de Vrueh RL, Rhie JK, Covitz KM, Smith PL, Lee CP, Oh DM, Sadée W, Amidon GL. 5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharmaceutical Research. 15: 1154-9. PMID 9706043 DOI: 10.1023/A:1011919319810 |
0.418 |
|
| 1998 |
Yu LX, Amidon GL. Saturable small intestinal drug absorption in humans: Modeling and interpretation of cefatrizine data European Journal of Pharmaceutics and Biopharmaceutics. 45: 199-203. PMID 9704917 DOI: 10.1016/S0939-6411(97)00088-X |
0.395 |
|
| 1998 |
Idkaidek NM, Amidon GL, Smith DE, Najib NM, Hassan MM. Determination of the population pharmacokinetic parameters of sustained-release and enteric-coated oral formulations, and the suppository formulation of diclofenac sodium by simultaneous data fitting using NONMEM. Biopharmaceutics & Drug Disposition. 19: 169-74. PMID 9570000 DOI: 10.1002/(Sici)1099-081X(199804)19:3<169::Aid-Bdd83>3.0.Co;2-C |
0.341 |
|
| 1998 |
Croyle MA, Walter E, Janich S, Roessler BJ, Amidon GL. Role of integrin expression in adenovirus-mediated gene delivery to the intestinal epithelium. Human Gene Therapy. 9: 561-73. PMID 9525317 DOI: 10.1089/Hum.1998.9.4-561 |
0.319 |
|
| 1998 |
Rhie JK, Hayashi Y, Welage LS, Frens J, Wald RJ, Barnett JL, Amidon GE, Putcha L, Amidon GL. Drug marker absorption in relation to pellet size, gastric motility and viscous meals in humans. Pharmaceutical Research. 15: 233-8. PMID 9523309 DOI: 10.1023/A:1011962501270 |
0.352 |
|
| 1998 |
Dressman JB, Amidon GL, Reppas C, Shah VP. Dissolution testing as a prognostic tool for oral drug absorption: Immediate release dosage forms Pharmaceutical Research. 15: 11-22. PMID 9487541 DOI: 10.1023/A:1011984216775 |
0.359 |
|
| 1998 |
Takamatsu N, Welage LS, Idkaidek NM, Liu DY, Lee PI, Hayashi Y, Rhie JK, Lennernäs H, Barnett JL, Shah VP, Lesko L, Amidon GL. Human intestinal permeability of piroxicam, propranolol, phenylalanine, and PEG 400 determined by jejunal perfusion. Pharmaceutical Research. 14: 1127-32. PMID 9327437 DOI: 10.1023/A:1012134219095 |
0.426 |
|
| 1997 |
Yu LX, Lipka E, Crison JR, Amidon GL. Transport approaches to the biopharmaceutical design of oral drug delivery systems: prediction of intestinal absorption. Advanced Drug Delivery Reviews. 19: 359-76. PMID 11540095 DOI: 10.1016/0169-409X(96)00009-9 |
0.381 |
|
| 1997 |
Desai MP, Labhasetwar V, Walter E, Levy RJ, Amidon GL. The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharmaceutical Research. 14: 1568-73. PMID 9434276 DOI: 10.1023/A:1012126301290 |
0.506 |
|
| 1997 |
Bowe CL, Mokhtarzadeh L, Venkatesan P, Babu S, Axelrod HR, Sofia MJ, Kakarla R, Chan TY, Kim JS, Lee HJ, Amidon GL, Choe SY, Walker S, Kahne D. Design of compounds that increase the absorption of polar molecules. Proceedings of the National Academy of Sciences of the United States of America. 94: 12218-23. PMID 9342389 DOI: 10.1073/Pnas.94.22.12218 |
0.639 |
|
| 1997 |
Cheng CL, Smith DE, Carver PL, Cox SR, Watkins PB, Blake DS, Kauffman CA, Meyer KM, Amidon GL, Stetson PL. Steady-state pharmacokinetics of delavirdine in HIV-positive patients: Effect on erythromycin breath test Clinical Pharmacology and Therapeutics. 61: 531-543. PMID 9164415 DOI: 10.1016/S0009-9236(97)90133-8 |
0.337 |
|
| 1997 |
Crison JR, Weiner ND, Amidon GL. Dissolution media for in vitro testing of water-insoluble drugs: effect of surfactant purity and electrolyte on in vitro dissolution of carbamazepine in aqueous solutions of sodium lauryl sulfate. Journal of Pharmaceutical Sciences. 86: 384-8. PMID 9050810 DOI: 10.1021/Js960105T |
0.328 |
|
| 1997 |
Crison JR, Shah VP, Skelly JP, Amidon GL. Drug dissolution into micellar solutions: development of a convective diffusion model and comparison to the film equilibrium model with application to surfactant-facilitated dissolution of carbamazepine. Journal of Pharmaceutical Sciences. 85: 1005-11. PMID 8877894 DOI: 10.1021/Js930336P |
0.389 |
|
| 1997 |
Cook TJ, Amidon GL, Yang VC. Polypeptides for controlled release applications: Synthesis and preliminary characterization and release studies International Journal of Pharmaceutics. 159: 197-206. DOI: 10.1016/S0378-5173(97)00308-6 |
0.305 |
|
| 1997 |
Langguth P, Bohner V, Heizmann J, Merkle H, Wolffram S, Amidon G, Yamashita S. The challenge of proteolytic enzymes in intestinal peptide delivery Journal of Controlled Release. 46: 39-57. DOI: 10.1016/S0168-3659(96)01586-6 |
0.362 |
|
| 1997 |
Walter E, Croyle MA, Davidson BL, Roessler BJ, Hilfinger JM, Amidon GL. Adenovirus mediated gene transfer to intestinal epithelial cells as a potential approach for oral delivery of peptides and proteins Journal of Controlled Release. 46: 75-87. DOI: 10.1016/S0168-3659(96)01584-2 |
0.323 |
|
| 1996 |
Lipka E, Crison J, Amidon GL. Transmembrane transport of peptide type compounds: Prospects for oral delivery Journal of Controlled Release. 39: 121-129. PMID 11539926 DOI: 10.1016/0168-3659(95)00145-X |
0.356 |
|
| 1996 |
Desai MP, Labhasetwar V, Amidon GL, Levy RJ. Gastrointestinal uptake of biodegradable microparticles: Effect of particle size Pharmaceutical Research. 13: 1838-1845. PMID 8987081 DOI: 10.1023/A:1016085108889 |
0.516 |
|
| 1996 |
Covitz KMY, Amidon GL, Sadée W. Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells Pharmaceutical Research. 13: 1631-1634. PMID 8956326 DOI: 10.1023/A:1016476220296 |
0.356 |
|
| 1996 |
Walter E, Janich S, Roessler BJ, Hilfinger JM, Amidon GL. HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: in vitro-in vivo correlation with permeability data from rats and humans. Journal of Pharmaceutical Sciences. 85: 1070-6. PMID 8897273 DOI: 10.1021/Js960110X |
0.444 |
|
| 1996 |
Lennemäs H, Knutson L, Knutson T, Lesko L, Salmonson T, Amidon G. Human effective permeability data forrurosemide, hydrochlorthiazide, ketoprofen and naproxen to be used in the proposed biopharmaceutical drug classification system for IR-products European Journal of Pharmaceutical Sciences. 4: S152. DOI: 10.1016/S0928-0987(97)86464-0 |
0.352 |
|
| 1996 |
Lennernäs H, Knutson L, Lesko L, Salmonson T, Amidon G. A ten-fold lower human jejunal Peff-value for α-methyldopa compared to L-dopa ar a similar luminal concentration of these two drugs European Journal of Pharmaceutical Sciences. 4: S75. DOI: 10.1016/S0928-0987(97)86241-0 |
0.353 |
|
| 1996 |
Amidon GL. Prodrugs topical and ocular drug delivery Journal of Controlled Release. 38: 96-97. DOI: 10.1016/S0168-3659(96)90023-1 |
0.386 |
|
| 1996 |
Walter E, Kissel T, Amidon GL. The intestinal peptide carrier: A potential transport system for small peptide derived drugs Advanced Drug Delivery Reviews. 20: 33-58. DOI: 10.1016/0169-409X(95)00129-U |
0.37 |
|
| 1996 |
Lipka E, Crison JR, Schug BS, Blume HH, Amidon GL. Drug Interactions in the Gastrointestinal Tract and Their Impact on Drug Absorption and Systemic Availability: A Mechanistic Review Handbook of Experimental Pharmacology. 122: 13-43. DOI: 10.1007/978-3-642-61015-8_2 |
0.401 |
|
| 1995 |
Lennernäs H, Crison JR, Amidon GL. Permeability and clearance views of drug absorption: A commentary Journal of Pharmacokinetics and Biopharmaceutics. 23: 333-337. PMID 8834200 DOI: 10.1007/Bf02354289 |
0.396 |
|
| 1995 |
Lipka E, Lee ID, Langguth P, Spahn-Langguth H, Mutschler E, Amidon GL. Celiprolol double-peak occurrence and gastric motility: Nonlinear mixed effects modeling of bioavailability data obtained in dogs Journal of Pharmacokinetics and Biopharmaceutics. 23: 267-286. PMID 8834196 DOI: 10.1007/Bf02354285 |
0.349 |
|
| 1995 |
Sadée W, Drübbisch V, Amidon GL. Biology of Membrane Transport Proteins Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12: 1823-1837. PMID 8786953 DOI: 10.1023/A:1016211015926 |
0.347 |
|
| 1995 |
Polli JE, Amidon GL. Mathematical model and dimensional analysis of glycocholate binding to cholestyramine resin: Implications for in vivo resin performance Journal of Pharmaceutical Sciences. 84: 1446-1454. PMID 8748328 DOI: 10.1002/Jps.2600841212 |
0.326 |
|
| 1995 |
Langguth P, Lee KM, Spahn-Langguth H, Amidon GL. Variable gastric emptying and discontinuities in drug absorption profiles: dependence of rates and extent of cimetidine absorption on motility phase and pH. Biopharmaceutics & Drug Disposition. 15: 719-46. PMID 7888602 DOI: 10.1002/Bdd.2510150902 |
0.351 |
|
| 1995 |
Su SF, Amidon GL. Investigation into the intestinal metabolism of [D-Ala1] peptide T amide: implication for oral drug delivery. Biochimica Et Biophysica Acta. 1245: 62-8. PMID 7654767 DOI: 10.1016/0304-4165(95)00063-H |
0.31 |
|
| 1995 |
Bleske BE, Welage LS, Rose S, Amidon GL, Shea MJ. The effect of dosage release formulations on the pharmacokinetics of propranolol stereoisomers in humans. Journal of Clinical Pharmacology. 35: 374-8. PMID 7650226 DOI: 10.1002/J.1552-4604.1995.Tb04076.X |
0.312 |
|
| 1995 |
Amidon GL, Lennernäs H, Shah VP, Crison JR. A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12: 413-420. PMID 7617530 DOI: 10.1023/A:1016212804288 |
0.445 |
|
| 1995 |
Mummaneni V, Amidon GL, Dressman JB. Gastric pH Influences the Appearance of Double Peaks in the Plasma Concentration-Time Profiles of Cimetidine After Oral Administration in Dogs Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12: 780-786. PMID 7479568 DOI: 10.1023/A:1016284214708 |
0.309 |
|
| 1995 |
Oh DM, Amidon GL, Sadee W. Functional expressions of endogenous dipeptide transporter and exogenous proton/peptide cotransporter in Xenopus oocytes Archives of Pharmacal Research. 18: 12-17. DOI: 10.1007/Bf02976500 |
0.338 |
|
| 1995 |
Oh DM, Curl RL, Yong CS, Amidon GL. Effect of micronization on the extent of drug absorption from suspensions in humans Archives of Pharmacal Research. 18: 427-433. DOI: 10.1007/Bf02976347 |
0.38 |
|
| 1994 |
Langguth P, Merkle HP, Amidon GL. Oral Absorption of Peptides: The Effect of Absorption Site and Enzyme Inhibition on the Systemic Availability of Metkephamid Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 11: 528-535. PMID 8058610 DOI: 10.1023/A:1018962415287 |
0.352 |
|
| 1994 |
Amidon GL, Lee HJ. Absorption of peptide and peptidomimetic drugs Annual Review of Pharmacology and Toxicology. 34: 321-341. PMID 8042854 DOI: 10.1146/Annurev.Pa.34.040194.001541 |
0.418 |
|
| 1994 |
Yu DM, Amidon GL, Weiner ND, Fleisher D, Goldberg AH. The role of rheological properties in mucociliary transport by frog palate ciliated model. Pharmaceutical Research. 11: 1785-91. PMID 7899245 DOI: 10.1023/A:1018927719656 |
0.31 |
|
| 1994 |
Schwendeman SP, Amidon GL, Labhasetwar V, Levy RJ. Modulated drug release using iontophoresis through heterogeneous cation- exchange membranes. 2. Influence of cation-exchanger content on membrane resistance and characteristic times Journal of Pharmaceutical Sciences. 83: 1482-1494. PMID 7884674 DOI: 10.1002/Jps.2600831023 |
0.681 |
|
| 1994 |
Oh DM, Amidon GL. Prediction of drug-drug interaction during oral absorption of carrier-mediated compounds in humans Archives of Pharmacal Research. 17: 364-370. DOI: 10.1007/Bf02974178 |
0.417 |
|
| 1994 |
Bai JPF, Stewart BH, Amidon GL. Gastrointestinal Transport of Peptide and Protein Drugs and Prodrugs Handbook of Experimental Pharmacology. 110: 189-206. DOI: 10.1007/978-3-642-78680-8_6 |
0.327 |
|
| 1993 |
Yuasa H, Amidon GL, Fleisher D. Peptide Carrier-Mediated Transport in Intestinal Brush Border Membrane Vesicles of Rats and Rabbits: Cephradine Uptake and Inhibition Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 400-404. PMID 8464813 DOI: 10.1023/A:1018940306394 |
0.369 |
|
| 1993 |
Sinko PJ, Leesman GD, Amidon GL. Mass Balance Approaches for Estimating the Intestinal Absorption and Metabolism of Peptides and Analogues: Theoretical Development and Applications Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 271-275. PMID 8456076 DOI: 10.1023/A:1018999130076 |
0.598 |
|
| 1993 |
Oh DM, Curl RL, Amidon GL. Estimating the Fraction Dose Absorbed from Suspensions of Poorly Soluble Compounds in Humans: A Mathematical Model Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 264-270. PMID 8456075 DOI: 10.1023/A:1018947113238 |
0.327 |
|
| 1993 |
Luner PE, Amidon GL. Description and simulation of a multiple mixing tank model to predict the effect of bile sequestrants on bile salt excretion Journal of Pharmaceutical Sciences. 82: 311-318. PMID 8450428 DOI: 10.1002/Jps.2600820319 |
0.315 |
|
| 1993 |
Oh DM, Sinko PJ, Amidon GL. Characterization of the oral absorption of some β-lactams: Effect of the α-amino side chain group Journal of Pharmaceutical Sciences. 82: 897-900. PMID 8229687 DOI: 10.1002/Jps.2600820907 |
0.58 |
|
| 1993 |
Schwendeman SP, Amidon GL, Levy RJ. Determinants of the modulated release of antiarrhythmic drugs by iontophoresis through polymer membranes Macromolecules. 26: 2264-2272. DOI: 10.1021/Ma00061A020 |
0.708 |
|
| 1992 |
Doo-Man Oh, Sinko PJ, Amidon GL. Characterization of the oral absorption of several aminopenicillins: Determination of intrinsic membrane absorption parameters in the rat intestine in situ International Journal of Pharmaceutics. 85: 181-187. PMID 11537280 DOI: 10.1016/0378-5173(92)90147-T |
0.537 |
|
| 1992 |
Bai JPF, Hu M, Subramanian P, Mosberg HI, Amidon GL. Utilization of peptide carrier system to improve intestinal absorption: Targeting prolidase as a prodrug-converting enzyme Journal of Pharmaceutical Sciences. 81: 113-116. PMID 1545347 DOI: 10.1002/Jps.2600810202 |
0.327 |
|
| 1992 |
Bai JPF, Amidon GL. Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug Delivery Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 9: 969-978. PMID 1409387 DOI: 10.1023/A:1015885823793 |
0.41 |
|
| 1992 |
Schwendeman SP, Amidon GL, Meyerhoff ME, Levy RJ. Modulated drug release using iontophoresis through heterogeneous cation exchange membranes: membrane preparation and influence of resin crosslinkage Macromolecules. 25: 2531-2540. DOI: 10.1021/Ma00035A036 |
0.687 |
|
| 1991 |
Kou JH, Fleisher D, Amidon GL. Calculation of the Aqueous Diffusion Layer Resistance for Absorption in a Tube: Application to Intestinal Membrane Permeability Determination Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 298-305. PMID 2052515 DOI: 10.1023/A:1015829128646 |
0.336 |
|
| 1991 |
Friedman DI, Amidon GL. Oral Absorption of Peptides: Influence of pH and Inhibitors on the Intestinal Hydrolysis of Leu-Enkephalin and Analogues Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 93-96. PMID 2014216 DOI: 10.1023/A:1015842609565 |
0.342 |
|
| 1991 |
Sinko PJ, Leesman GD, Amidon GL. Predicting Fraction Dose Absorbed in Humans Using a Macroscopic Mass Balance Approach Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 979-988. PMID 1924168 DOI: 10.1023/A:1015892621261 |
0.6 |
|
| 1991 |
Lui CY, Amidon GL, Goldberg A. Intranasal absorption of flurazepam, midazolam, and triazolam in dogs Journal of Pharmaceutical Sciences. 80: 1125-1129. PMID 1815070 DOI: 10.1002/Jps.2600801207 |
0.361 |
|
| 1991 |
Chu JS, Chandrasekharan R, Amidon GL, Weiner ND, Goldberg AH. Viscometric study of polyacrylic acid systems as mucoadhesive sustained-release gels. Pharmaceutical Research. 8: 1408-12. PMID 1798678 DOI: 10.1023/A:1015805307999 |
0.37 |
|
| 1991 |
Amidon GL, DeBrincat GA, Najib N. Effects of gravity on gastric emptying, intestinal transit, and drug absorption Journal of Clinical Pharmacology. 31: 968-973. PMID 1761729 DOI: 10.1002/J.1552-4604.1991.Tb03658.X |
0.36 |
|
| 1990 |
Tsuji A, Tamai I, Nakanishi M, Amidon GL. Mechanism of absorption of the dipeptide alpha-methyldopa-phe in intestinal brush-border membrane vesicles. Pharmaceutical Research. 7: 308-9. PMID 2339108 DOI: 10.1023/A:1015894617027 |
0.371 |
|
| 1990 |
Choi HK, Flynn GL, Amidon GL. Transdermal Delivery of Bioactive Peptides: The Effect of n-Decylmethyl Sulfoxide, pH, and Inhibitors on Enkephalin Metabolism and Transport Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 7: 1099-1106. PMID 2293206 DOI: 10.1023/A:1015915922363 |
0.325 |
|
| 1990 |
Donovan MD, Flynn GL, Amidon GL. The Molecular Weight Dependence of Nasal Absorption: The Effect of Absorption Enhancers Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 7: 808-815. PMID 2235878 DOI: 10.1023/A:1015904730599 |
0.338 |
|
| 1990 |
Johnston TP, Boyd JA, Ciesliga BL, Schoen FJ, Amidon G, Levy RJ. Controlled release of ethanehydroxy diphosphonate from polyurethane reservoirs to inhibit calcification of bovine pericardium used in bioprosthetic heart valves International Journal of Pharmaceutics. 59: 95-104. DOI: 10.1016/0378-5173(90)90083-G |
0.479 |
|
| 1990 |
Kou JH, Fleisher D, Amidon GL. Modeling drug release from dynamically swelling poly(hydroxyethyl methacrylate-co-methacrylic acid) hydrogels Journal of Controlled Release. 12: 241-250. DOI: 10.1016/0168-3659(90)90105-3 |
0.379 |
|
| 1990 |
Amidon GL. Specialized drug delivery systems manufacturing and production technology Journal of Controlled Release. 14: 107. DOI: 10.1016/0168-3659(90)90065-2 |
0.317 |
|
| 1990 |
Skelly JP, Amidon GL, Barr WH, Benet LZ, Carter JE, Robinson JR, Shah VP, Yacobi A. In vitro and in vivo testing and correlation for oral controlled/ modified release dosage forms. report of the 2nd workshop held December 1988, Washington, DC. U.S.A. Journal of Controlled Release. 14: 95-106. DOI: 10.1016/0168-3659(90)90064-Z |
0.396 |
|
| 1990 |
Friedman DI, Amidon GL. Characterization of the intestinal transport parameters for small peptide drugs Journal of Controlled Release. 13: 141-146. DOI: 10.1016/0168-3659(90)90005-E |
0.376 |
|
| 1989 |
Hu M, Subramanian P, Mosberg HI, Amidon GL. Use of the Peptide Carrier System to Improve the Intestinal Absorption of L-α-Methyldopa: Carrier Kinetics, Intestinal Permeabilities, and In Vitro Hydrolysis of Dipeptidyl Derivatives of L-α-Methyldopa Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 6: 66-70. PMID 2717522 DOI: 10.1023/A:1015855820488 |
0.351 |
|
| 1989 |
Sinko PJ, Amidon GL. Characterization of the oral absorption of β-lactam antibiotics II: Competitive absorption and peptide carrier specificity Journal of Pharmaceutical Sciences. 78: 723-727. PMID 2585263 DOI: 10.1002/Jps.2600780904 |
0.581 |
|
| 1989 |
Friedman DI, Amidon GL. Passive and Carrier-Mediated Intestinal Absorption Components of Two Angiotensin Converting Enzyme (ACE) Inhibitor Prodrugs in Rats: Enalapril and Fosinopril Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 6: 1043-1047. PMID 2560181 DOI: 10.1023/A:1015978420797 |
0.401 |
|
| 1989 |
Friedman DI, Amidon GL. Intestinal absorption mechanism of dipeptide angiotensin converting enzyme inhibitors of the lysyl-proline type: Lisinopril and SQ 29,852 Journal of Pharmaceutical Sciences. 78: 995-998. PMID 2559191 DOI: 10.1002/Jps.2600781205 |
0.35 |
|
| 1989 |
Johnston TP, Bove EL, Bolling SF, Boyd JA, Ciesliga BL, Amidon GL, Schoen FJ, Levy RJ. Controlled release of 1-hydroxyethylidene diphosphonate: in vitro assessment and effects on bioprosthetic calcification in sheep tricuspid valve replacements International Journal of Pharmaceutics. 52: 139-148. DOI: 10.1016/0378-5173(89)90288-3 |
0.494 |
|
| 1988 |
Hu M, Sinko PJ, deMeere AL, Johnson DA, Amidon GL. Membrane permeability parameters for some amino acids and beta-lactam antibiotics: application of the boundary layer approach. Journal of Theoretical Biology. 131: 107-14. PMID 3419188 DOI: 10.1016/S0022-5193(88)80124-3 |
0.598 |
|
| 1988 |
Amidon GL, Sinko PJ, Fleisher D. Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 5: 651-654. PMID 3244618 DOI: 10.1023/A:1015927004752 |
0.633 |
|
| 1988 |
Sinko PJ, Amidon GL. Characterization of the Oral Absorption of β-Lactam Antibiotics. I. Cephalosporins: Determination of Intrinsic Membrane Absorption Parameters in the Rat Intestine In Situ Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 5: 645-650. PMID 3244617 DOI: 10.1023/A:1015974920682 |
0.527 |
|
| 1988 |
McNamara DP, Amidon GL. Reaction plane approach for estimating the effects of buffers on the dissolution rate of acidic drugs Journal of Pharmaceutical Sciences. 77: 511-517. PMID 3171931 DOI: 10.1002/Jps.2600770610 |
0.326 |
|
| 1988 |
Hu M, Amidon GL. Passive and carrier-mediated intestinal absorption components of captopril Journal of Pharmaceutical Sciences. 77: 1007-1011. PMID 3072405 DOI: 10.1002/Jps.2600771204 |
0.374 |
|
| 1987 |
Oberle RL, Amidon GL. The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine; an explanation for the double peak phenomenon Journal of Pharmacokinetics and Biopharmaceutics. 15: 529-544. PMID 3694496 DOI: 10.1007/Bf01061761 |
0.303 |
|
| 1987 |
Sinko PJ, Ming Hu, Amidon GL. Carrier mediated transport of amino acids, small peptides, and their drug analogs Journal of Controlled Release. 6: 115-121. DOI: 10.1016/0168-3659(87)90069-1 |
0.616 |
|
| 1986 |
Stewart BH, Amidon GL, Brabec RK. Uptake of prodrugs by rat intestinal mucosal cells: Mechanism and pharmaceutical implications Journal of Pharmaceutical Sciences. 75: 940-945. PMID 3795023 DOI: 10.1002/Jps.2600751005 |
0.374 |
|
| 1986 |
Fleisher D, Johnson KC, Stewart BH, Amidon GL. Oral absorption of 21-corticosteroid esters: A function of aqueous stability and intestinal enzyme activity and distribution Journal of Pharmaceutical Sciences. 75: 934-939. PMID 3795022 DOI: 10.1002/Jps.2600751004 |
0.396 |
|
| 1986 |
Lui CY, Amidon GL, Berardi RR, Fleisher D, Youngberg C, Dressman JB. Comparison of gastrointestinal pH in dogs and humans: implications on the use of the beagle dog as a model for oral absorption in humans. Journal of Pharmaceutical Sciences. 75: 271-4. PMID 3701609 DOI: 10.1002/Jps.2600750313 |
0.33 |
|
| 1986 |
Amidon GL, Merfeld AE, Dressman JB. Concentration and pH dependency of α-methyldopa absorption in rat intestine Journal of Pharmacy and Pharmacology. 38: 363-368. PMID 2872312 DOI: 10.1111/J.2042-7158.1986.Tb04588.X |
0.357 |
|
| 1985 |
Johnson K, Amidon GL, Pogany S. Solution kinetics of a water-soluble hydrocortisone prodrug: Hydrocortisone-21-lysinate Journal of Pharmaceutical Sciences. 74: 87-89. PMID 3981427 DOI: 10.1002/Jps.2600740124 |
0.315 |
|
| 1985 |
Fleisher D, Stewart BH, Amidon GL. Design of prodrugs for improved gastrointestinal absorption by intestinal enzyme targeting Methods in Enzymology. 360-381. PMID 3900636 DOI: 10.1016/S0076-6879(85)12030-6 |
0.448 |
|
| 1985 |
Amidon GL, Stewart BH, Pogany S. Improving the intestinal mucosal cell uptake of water insoluble compounds Journal of Controlled Release. 2: 13-26. DOI: 10.1016/0168-3659(85)90029-X |
0.363 |
|
| 1984 |
Dressman JB, Fleisher D, Amidon GL. Physicochemical model for dose-dependent drug absorption Journal of Pharmaceutical Sciences. 73: 1274-1279. PMID 6548523 DOI: 10.1002/Jps.2600730922 |
0.411 |
|
| 1983 |
Amidon GL, Lee M, Lee H. Intestinal absorption of amino acid derivatives: Structural requirements for membrane hydrolysis Journal of Pharmaceutical Sciences. 72: 943-944. PMID 6413676 DOI: 10.1002/Jps.2600720826 |
0.367 |
|
| 1982 |
Selen A, Amidon GL, Welling PG. Pharmacokinetics of probenecid following oral doses of human volunteers Journal of Pharmaceutical Sciences. 71: 1238-1242. PMID 7175716 DOI: 10.1002/Jps.2600711114 |
0.316 |
|
| 1982 |
Amidon GL, Chang M, Fleisher D, Allen R. Intestinal absorption of amino acid derivatives: Importance of the free α-amino group Journal of Pharmaceutical Sciences. 71: 1138-1141. PMID 7143212 DOI: 10.1002/Jps.2600711015 |
0.302 |
|
| 1981 |
Banerjee PK, Amidon GL. Physicochemical property modification strategies based on enzyme substrate specificities III: Carboxypeptidase A hydrolysis of aspirin derivatives Journal of Pharmaceutical Sciences. 70: 1307-1309. PMID 7320841 DOI: 10.1002/Jps.2600701204 |
0.356 |
|
| 1981 |
Banerjee PK, Amidon GL. Physicochemical property modification strategies based on enzyme substrate specificities II: α-chymotrypsin hydrolysis of aspirin derivatives Journal of Pharmaceutical Sciences. 70: 1304-1306. PMID 7320840 DOI: 10.1002/Jps.2600701203 |
0.316 |
|
| 1981 |
Banerjee PK, Amidon GL. Physicochemical property modification strategies based on enzyme substrate specificities I: Rationale, synthesis, and pharmaceutical properties of aspirin derivatives Journal of Pharmaceutical Sciences. 70: 1299-1303. PMID 7320839 DOI: 10.1002/Jps.2600701202 |
0.359 |
|
| 1980 |
Amidon GL, Leesman GD, Elliott RL. Improving intestinal absorption of water-insoluble compounds: A membrane metabolism strategy Journal of Pharmaceutical Sciences. 69: 1363-1368. PMID 6780682 DOI: 10.1002/Jps.2600691203 |
0.402 |
|
| 1976 |
Yalkowsky SH, Valvani SC, Amidon GL. Solubility of nonelectrolytes in polar solvents. IV. Nonpolar drugs in mixed solvents Journal of Pharmaceutical Sciences. 65: 1488-1494. PMID 978408 DOI: 10.1002/Jps.2600651018 |
0.349 |
|
| 1973 |
Welling PG, Craig WA, Amidon GL, Kunin CM. Pharmacokinetics of trimethoprim and sulfamethoxazole in normal subjects and in patients with renal failure. The Journal of Infectious Diseases. 128: Suppl:556-66 p. PMID 4758046 DOI: 10.1093/Infdis/128.Supplement_3.S556 |
0.325 |
|
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