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Kevin C. Kain - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Cell Biology, Microbiology Biology
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273 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Mishra H, Ngai M, Crowley VM, Tran V, Painaga MSS, Gaite JY, Hamilton P, Kain KC, Hawkes MT. The Angiopoietin-Tie-2 Axis in Children and Young Adults with Dengue Virus Infection in the Philippines. The American Journal of Tropical Medicine and Hygiene. PMID 39137755 DOI: 10.4269/ajtmh.24-0115  0.51
2024 Mishra H, Balanza N, Francis C, Zhong K, Wright J, Conroy AL, Opoka RO, Bassat Q, Namasopo S, Kain KC, Hawkes MT. Heparin-Binding Protein Stratifies Mortality Risk Among Ugandan Children Hospitalized With Respiratory Distress. Open Forum Infectious Diseases. 11: ofae386. PMID 39022391 DOI: 10.1093/ofid/ofae386  0.651
2023 Varo R, Crowley VM, Mucasse H, Sitoe A, Bramugy J, Serghides L, Weckman AM, Erice C, Bila R, Vitorino P, Mucasse C, Valente M, Ajanovic S, Balanza N, Zhong K, ... ... Kain KC, et al. Adjunctive rosiglitazone treatment for severe pediatric malaria: A randomized placebo-controlled trial in Mozambican children. International Journal of Infectious Diseases : Ijid : Official Publication of the International Society For Infectious Diseases. 139: 34-40. PMID 38013152 DOI: 10.1016/j.ijid.2023.11.031  0.632
2023 Wright JK, Weckman AM, Ngai M, Stefanova V, Zhong K, McDonald CR, Elphinstone RE, Conroy AL, Coburn BA, Madanitsa M, Taylor SM, Ter Kuile FO, Kain KC. Intestinal barrier disruption with Plasmodium falciparum infection in pregnancy and risk of preterm birth: a cohort study. Ebiomedicine. 97: 104808. PMID 37837932 DOI: 10.1016/j.ebiom.2023.104808  0.524
2023 Weckman AM, McDonald CR, Ngai M, Richard-Greenblatt M, Leligdowicz A, Conroy AL, Kain KC, Namasopo S, Hawkes MT. Inflammatory profiles in febrile children with moderate and severe malnutrition presenting at-hospital in Uganda are associated with increased mortality. Ebiomedicine. 94: 104721. PMID 37467665 DOI: 10.1016/j.ebiom.2023.104721  0.672
2023 Weckman AM, Elphinstone RE, Ssenkusu JM, Tran V, Zhong K, Madanitsa M, Khairallah C, Kalilani-Phiri L, Mwapasa V, Conroy AL, Ter Kuile FO, McDonald CR, Kain KC. Sequential disruptions to inflammatory and angiogenic pathways and risk of spontaneous preterm birth in Malawian women. Iscience. 26: 106912. PMID 37332611 DOI: 10.1016/j.isci.2023.106912  0.486
2023 Mitran C, Opoka RO, Conroy AL, Namasopo S, Kain KC, Hawkes MT. Pediatric Malaria with Respiratory Distress: Prognostic Significance of Point-of-Care Lactate. Microorganisms. 11. PMID 37110346 DOI: 10.3390/microorganisms11040923  0.686
2022 McDonald CR, Weckman AM, Wright JK, Conroy AL, Kain KC. Developmental origins of disease highlight the immediate need for expanded access to comprehensive prenatal care. Frontiers in Public Health. 10: 1021901. PMID 36504964 DOI: 10.3389/fpubh.2022.1021901  0.463
2022 Saghian R, Cahill LS, Debebe SK, Rahman A, Serghides L, McDonald CR, Weckman AM, Kain KC, Sled JG. Allometric scaling relationships in mouse placenta. Journal of the Royal Society, Interface. 19: 20220579. PMID 36349448 DOI: 10.1098/rsif.2022.0579  0.564
2022 McDonald CR, Weckman AM, Richardson E, Hawkes MT, Leligdowicz A, Namasopo S, Opoka RO, Conroy AL, Kain KC. Sex as a determinant of disease severity and clinical outcome in febrile children under five presenting to a regional referral hospital in Uganda. Plos One. 17: e0276234. PMID 36269702 DOI: 10.1371/journal.pone.0276234  0.676
2022 Ngai M, Hawkes MT, Erice C, Weckman AM, Wright J, Stefanova V, Opoka RO, Namasopo S, Conroy AL, Kain KC. Intestinal injury in Ugandan children hospitalized with malaria. The Journal of Infectious Diseases. PMID 35942812 DOI: 10.1093/infdis/jiac340  0.666
2022 McDonald CR, Leligdowicz A, Conroy AL, Weckman AM, Richard-Greenblatt M, Ngai M, Erice C, Zhong K, Namasopo S, Opoka RO, Hawkes MT, Kain KC. Immune and endothelial activation markers and risk stratification of childhood pneumonia in Uganda: A secondary analysis of a prospective cohort study. Plos Medicine. 19: e1004057. PMID 35830474 DOI: 10.1371/journal.pmed.1004057  0.676
2022 Conroy AL, Hawkes MT, Leligdowicz A, Mufumba I, Starr MC, Zhong K, Namasopo S, John CC, Opoka RO, Kain KC. Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance. Bmc Medicine. 20: 221. PMID 35773743 DOI: 10.1186/s12916-022-02410-4  0.611
2022 Stefanova V, Crowley VM, Weckman AM, Kain KC. suPAR to Risk-Stratify Patients With Malaria. Frontiers in Immunology. 13: 931321. PMID 35757694 DOI: 10.3389/fimmu.2022.931321  0.333
2022 Stefanova V, Ngai M, Weckman AM, Wright JK, Zhong K, Richard-Greenblatt M, McDonald CR, Conroy AL, Namasopo S, Opoka RO, Hawkes M, Kain KC. suPAR as a Prognostic Marker of Ugandan Children at Risk of Severe and Fatal Malaria. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 35675322 DOI: 10.1093/cid/ciac457  0.697
2022 Hawkes MT, Leligdowicz A, Batte A, Situma G, Zhong K, Namasopo S, Opoka RO, Kain KC, Conroy AL. Pathophysiology of Acute Kidney Injury in Malaria and Non-Malarial Febrile Illness: A Prospective Cohort Study. Pathogens (Basel, Switzerland). 11. PMID 35456111 DOI: 10.3390/pathogens11040436  0.691
2021 Leligdowicz A, Conroy AL, Hawkes M, Richard-Greenblatt M, Zhong K, Opoka RO, Namasopo S, Bell D, Liles WC, da Costa BR, Jüni P, Kain KC. Risk-stratification of febrile African children at risk of sepsis using sTREM-1 as basis for a rapid triage test. Nature Communications. 12: 6832. PMID 34824252 DOI: 10.1038/s41467-021-27215-6  0.648
2021 Tran V, Weckman AM, Crowley VM, Cahill LS, Zhong K, Cabrera A, Elphinstone RE, Pearce V, Madanitsa M, Kalilani-Phiri L, Mwapasa V, Khairallah C, Conroy AL, Ter Kuile FO, Sled JG, ... Kain KC, et al. The Angiopoietin-Tie2 axis contributes to placental vascular disruption and adverse birth outcomes in malaria in pregnancy. Ebiomedicine. 73: 103683. PMID 34758414 DOI: 10.1016/j.ebiom.2021.103683  0.521
2021 Wang D, Darling AM, McDonald CR, Perumal N, Liu E, Wang M, Aboud S, Urassa W, Conroy AL, Hayford KT, Liles WC, Kain KC, Fawzi WW. Plasma concentrations of leptin at mid-pregnancy are associated with gestational weight gain among pregnant women in Tanzania: a prospective cohort study. Bmc Pregnancy and Childbirth. 21: 675. PMID 34615489 DOI: 10.1186/s12884-021-04146-0  0.456
2021 Weckman AM, Conroy AL, Madanitsa M, Gnaneswaran B, McDonald CR, Kalilani-Phiri L, Chandna J, Ali D, Mwapasa V, Khairallah C, Thwai KL, Meshnick SR, Taylor SM, Ter Kuile FO, Kain KC, et al. Neurocognitive outcomes in Malawian children exposed to malaria during pregnancy: An observational birth cohort study. Plos Medicine. 18: e1003701. PMID 34582452 DOI: 10.1371/journal.pmed.1003701  0.547
2021 Ouma BJ, Bangirana P, Ssenkusu JM, Datta D, Opoka RO, Idro R, Kain KC, John CC, Conroy AL. Plasma angiopoietin-2 is associated with age-related deficits in cognitive sub-scales in Ugandan children following severe malaria. Malaria Journal. 20: 17. PMID 33407493 DOI: 10.1186/s12936-020-03545-6  0.526
2020 McDonald CR, Weckman AM, Wright JK, Conroy AL, Kain KC. Pregnant Women in Low- and Middle-Income Countries Require a Special Focus During the COVID-19 Pandemic. Frontiers in Global Women's Health. 1: 564560. PMID 34816152 DOI: 10.3389/fgwh.2020.564560  0.444
2020 Balanza N, Erice C, Ngai M, Varo R, Kain KC, Bassat Q. Host-Based Prognostic Biomarkers to Improve Risk Stratification and Outcome of Febrile Children in Low- and Middle-Income Countries. Frontiers in Pediatrics. 8: 552083. PMID 33072673 DOI: 10.3389/fped.2020.552083  0.309
2020 Varo R, Erice C, Johnson S, Bassat Q, Kain KC. Clinical trials to assess adjuvant therapeutics for severe malaria. Malaria Journal. 19: 268. PMID 32709257 DOI: 10.1186/S12936-020-03340-3  0.397
2020 Ouma BJ, Ssenkusu JM, Shabani E, Datta D, Opoka RO, Idro R, Bangirana P, Park G, Joloba ML, Kain KC, John CC, Conroy AL. Endothelial Activation, Acute Kidney Injury, and Cognitive Impairment in Pediatric Severe Malaria. Critical Care Medicine. PMID 32618701 DOI: 10.1097/Ccm.0000000000004469  0.568
2020 Gautret P, Leder K, Field V, Kain KC, Hamer DH, Libman M. GeoSentinel surveillance of travel-associated infections: What lies in the future? Travel Medicine and Infectious Disease. 101600. PMID 32156631 DOI: 10.1016/J.Tmaid.2020.101600  0.312
2019 Ngai M, Weckman AM, Erice C, McDonald CR, Cahill LS, Sled JG, Kain KC. Malaria in Pregnancy and Adverse Birth Outcomes: New Mechanisms and Therapeutic Opportunities. Trends in Parasitology. PMID 31864896 DOI: 10.1016/J.Pt.2019.12.005  0.337
2019 Hawkes MT, Opoka RO, Conroy AL, Elphinstone RE, Hume HA, Namasopo S, Kain KC. Anemia and transfusion requirements among Ugandan children with severe malaria treated with intravenous artesunate. Pediatric Hematology and Oncology. 1-13. PMID 31826697 DOI: 10.1080/08880018.2019.1701161  0.698
2019 Erice C, Kain KC. New insights into microvascular injury to inform enhanced diagnostics and therapeutics for severe malaria. Virulence. 10: 1034-1046. PMID 31775570 DOI: 10.1080/21505594.2019.1696621  0.433
2019 Erice C, Kain KC. New insights into microvascular injury to inform enhanced diagnostics and therapeutics for severe malaria. Virulence. 10: 1034-1046. PMID 31775570 DOI: 10.1080/21505594.2019.1696621  0.321
2019 Elphinstone RE, Weckman AM, McDonald CR, Tran V, Zhong K, Madanitsa M, Kalilani-Phiri L, Khairallah C, Taylor SM, Meshnick SR, Mwapasa V, Ter Kuile FO, Conroy AL, Kain KC. Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study. Plos Medicine. 16: e1002914. PMID 31574087 DOI: 10.1371/Journal.Pmed.1002914  0.574
2019 Weckman AM, Ngai M, Wright J, McDonald CR, Kain KC. The Impact of Infection in Pregnancy on Placental Vascular Development and Adverse Birth Outcomes. Frontiers in Microbiology. 10: 1924. PMID 31507551 DOI: 10.3389/Fmicb.2019.01924  0.322
2019 Richard-Greenblatt M, Boillat-Blanco N, Zhong K, Mbarack Z, Samaka J, Mlaganile T, Kazimoto T, D'Acremont V, Kain KC. Prognostic accuracy of sTREM-1-based algorithms in febrile adults presenting to Tanzanian outpatient clinics. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 31102510 DOI: 10.1093/Cid/Ciz419  0.341
2019 Weckman AM, McDonald CR, Baxter JB, Fawzi WW, Conroy AL, Kain KC. Perspective: L-arginine and L-citrulline Supplementation in Pregnancy: A Potential Strategy to Improve Birth Outcomes in Low-Resource Settings. Advances in Nutrition (Bethesda, Md.). PMID 31075164 DOI: 10.1093/Advances/Nmz015  0.541
2019 McDonald CR, Weckman AM, Conroy AL, Olwoch P, Natureeba P, Kamya MR, Havlir DV, Dorsey G, Kain KC. Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole. Scientific Reports. 9: 6758. PMID 31043691 DOI: 10.1038/S41598-019-43191-W  0.559
2019 Mehta N, Perrais B, Martin K, Kumar A, Hobman TC, Cabalfin-Chua MN, Donaldo ME, Siose Painaga MS, Gaite JY, Tran V, Kain KC, Hawkes MT, Yanow SK. A Direct from Blood/Plasma Reverse Transcription-Polymerase Chain Reaction for Dengue Virus Detection in Point-of-Care Settings. The American Journal of Tropical Medicine and Hygiene. PMID 30994095 DOI: 10.4269/Ajtmh.19-0138  0.532
2019 Najjar N, McColl ER, Weckman A, Kain KC, Piquette-Miller M. Dysregulation of SLC Transporters in Malaria-Infected Pregnant Mice. Parasite Immunology. e12614. PMID 30703256 DOI: 10.1111/Pim.12614  0.308
2019 Labbé AC, Loutfy MR, Kain KC. Recent Advances in the Prophylaxis and Treatment of Malaria. Current Infectious Disease Reports. 3: 68-76. PMID 11177733 DOI: 10.1007/S11908-001-0061-0  0.376
2019 Gnaneswaran B, Conroy A, Madanitsa M, Gichuru P, Kain K, Gladstone MJ. Does Malaria In Pregnancy Affect Neurodevelopmental Outcomes F1000research. 9. DOI: 10.7490/F1000Research.1117807.1  0.559
2019 McCarthy A, Libman M, Yansouni C, Kuhn S, Geduld J, Hajek J, Ghesquiere W, Mirzanejad Y, Plewes K, Vincelette J, Barkati S, Ploude P, Greenaway C, Schwartz K, Thompson C, ... Kain K, et al. Malaria in Canadian VFRs and migrants: surveillance report from CanTravBet, April 2013 — March 2018 International Journal of Infectious Diseases. 79: 93-94. DOI: 10.1016/J.Ijid.2018.11.234  0.368
2018 McDonald CR, Weckman A, Richard-Greenblatt M, Leligdowicz A, Kain KC. Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness. Malaria Journal. 17: 353. PMID 30305137 DOI: 10.1186/S12936-018-2488-X  0.398
2018 Hawkes MT, Conroy AL, Namasopo S, Bhargava R, Kain KC, Mian Q, Opoka RO. Solar-Powered Oxygen Delivery in Low-Resource Settings: A Randomized Clinical Noninferiority Trial. Jama Pediatrics. PMID 29800014 DOI: 10.1001/Jamapediatrics.2018.0228  0.624
2018 Leligdowicz A, Richard-Greenblatt M, Wright J, Crowley VM, Kain KC. Endothelial Activation: The Ang/Tie Axis in Sepsis. Frontiers in Immunology. 9: 838. PMID 29740443 DOI: 10.3389/Fimmu.2018.00838  0.339
2018 McDonald CR, Cahill LS, Gamble JR, Elphinstone R, Gazdzinski LM, Zhong KJY, Philson AC, Madanitsa M, Kalilani-Phiri L, Mwapasa V, Ter Kuile FO, Sled JG, Conroy AL, Kain KC. Malaria in pregnancy alters l-arginine bioavailability and placental vascular development. Science Translational Medicine. 10. PMID 29514999 DOI: 10.1126/Scitranslmed.Aan6007  0.549
2018 Langlais D, Cencic R, Moradin N, Kennedy JM, Ayi K, Brown LE, Crandall I, Tarry MJ, Schmeing M, Kain KC, Porco JA, Pelletier J, Gros P. Rocaglates as dual-targeting agents for experimental cerebral malaria. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463745 DOI: 10.1073/Pnas.1713000115  0.371
2018 Conroy AL, Hawkes MT, Elphinstone R, Opoka RO, Namasopo S, Miller C, John CC, Kain KC. Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria. Malaria Journal. 17: 82. PMID 29448936 DOI: 10.1186/S12936-018-2225-5  0.706
2018 Bangirana P, Conroy AL, Opoka RO, Hawkes MT, Hermann L, Miller C, Namasopo S, Liles WC, John CC, Kain KC. Inhaled nitric oxide and cognition in pediatric severe malaria: A randomized double-blind placebo controlled trial. Plos One. 13: e0191550. PMID 29370261 DOI: 10.1371/Journal.Pone.0191550  0.677
2018 Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Kain KC, Bassat Q. Adjunctive therapy for severe malaria: a review and critical appraisal. Malaria Journal. 17: 47. PMID 29361945 DOI: 10.1186/S12936-018-2195-7  0.694
2017 Crowley VM, Ayi K, Lu Z, Liby KT, Sporn M, Kain KC. Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria. Malaria Journal. 16: 463. PMID 29137631 DOI: 10.1186/S12936-017-2109-0  0.411
2017 McDonald CR, Conroy AL, Gamble JL, Papp E, Hawkes M, Olwoch P, Natureeba P, Kamya M, Silverman M, Cohan D, Koss CA, Dorsey G, Kain KC, Serghides L. Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 29136115 DOI: 10.1093/Cid/Cix772  0.756
2017 Conroy AL, Mcdonald CR, Gamble JL, Olwoch P, Natureeba P, Cohan D, Kamya MR, Havlir DV, Dorsey G, Kain KC. Altered angiogenesis as a common mechanism underlying preterm birth, small-for-gestational age and stillbirth in women living with HIV. American Journal of Obstetrics and Gynecology. PMID 29031892 DOI: 10.1016/J.Ajog.2017.10.003  0.529
2017 Angelo KM, Libman M, Caumes E, Hamer DH, Kain KC, Leder K, Grobusch MP, Hagmann SH, Kozarsky P, Lalloo DG, Lim PL, Patimeteeporn C, Gautret P, Odolini S, Chappuis F, et al. Malaria after international travel: a GeoSentinel analysis, 2003-2016. Malaria Journal. 16: 293. PMID 28728595 DOI: 10.1186/S12936-017-1936-3  0.376
2017 Elphinstone RE, Besla R, Shikatani EA, Lu Z, Hausladen A, Davies M, Robbins CS, Husain M, Stamler JS, Kain KC. S-Nitrosoglutathione Reductase (GSNOR) Deficiency Confers Improved Survival and Neurological Outcome in Experimental Cerebral Malaria. Infection and Immunity. PMID 28674030 DOI: 10.1128/Iai.00371-17  0.409
2017 Varo R, Crowley VM, Sitoe A, Madrid L, Serghides L, Bila R, Mucavele H, Mayor A, Bassat Q, Kain KC. Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria. Malaria Journal. 16: 215. PMID 28535809 DOI: 10.1186/S12936-017-1858-0  0.696
2017 Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC. Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection. Plos One. 12: e0175130. PMID 28419100 DOI: 10.1371/Journal.Pone.0175130  0.69
2017 Barker KR, Lu Z, Kim H, Zheng Y, Chen J, Conroy AL, Hawkes M, Cheng HS, Njock MS, Fish JE, Harlan JM, López JA, Liles WC, Kain KC. miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria. Molecular Medicine (Cambridge, Mass.). 23. PMID 28182191 DOI: 10.2119/Molmed.2016.00139  0.666
2017 Boggild AK, McCarthy AE, Libman MD, Freedman DO, Kain KC. Underestimate of annual malaria imports to Canada. The Lancet. Infectious Diseases. 17: 141-142. PMID 28134112 DOI: 10.1016/S1473-3099(17)30010-5  0.394
2017 Darling AM, Mugusi FM, Etheredge AJ, Gunaratna NS, Abioye AI, Aboud S, Duggan C, Mongi R, Spiegelman D, Roberts D, Hamer DH, Kain KC, Fawzi WW. Vitamin A and Zinc Supplementation among Pregnant Women to Prevent Placental Malaria: A Randomized, Double-Blind, Placebo-Controlled Trial in Tanzania. The American Journal of Tropical Medicine and Hygiene. PMID 28115667 DOI: 10.4269/Ajtmh.16-0599  0.35
2016 Yegorov S, Galiwango RM, Ssemaganda A, Muwanga M, Wesonga I, Miiro G, Drajole DA, Kain KC, Kiwanuka N, Bagaya BS, Kaul R. Low prevalence of laboratory-confirmed malaria in clinically diagnosed adult women from the Wakiso district of Uganda. Malaria Journal. 15: 555. PMID 27842555 DOI: 10.1186/S12936-016-1604-Z  0.363
2016 Conroy AL, Hawkes M, Hayford K, Hermann L, McDonald CR, Sharma S, Namasopo S, Opoka RO, John CC, Liles WC, Miller C, Kain KC. Methemoglobin and nitric oxide therapy in Ugandan children hospitalized for febrile illness: results from a prospective cohort study and randomized double-blind placebo-controlled trial. Bmc Pediatrics. 16: 177. PMID 27814710 DOI: 10.1186/S12887-016-0719-2  0.681
2016 McDonald CR, Conroy AL, Hawkes M, Elphinstone RE, Gamble JL, Hayford K, Namasopo S, Opoka RO, Liles WC, Kain KC. Brain-Derived Neurotrophic Factor is Associated with Disease Severity and Clinical Outcome in Ugandan Children Admitted to Hospital with Severe Malaria. The Pediatric Infectious Disease Journal. PMID 27798544 DOI: 10.1097/Inf.0000000000001382  0.707
2016 Conroy AL, Hawkes M, McDonald CR, Kim H, Higgins SJ, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC. Host Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria. Open Forum Infectious Diseases. 3: ofw134. PMID 27703996 DOI: 10.1093/Ofid/Ofw134  0.73
2016 Higgins SJ, Purcell LA, Silver KL, Tran V, Crowley V, Hawkes M, Conroy AL, Opoka RO, Hay JG, Quaggin SE, Thurston G, Liles WC, Kain KC. Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria. Science Translational Medicine. 8: 358ra128. PMID 27683553 DOI: 10.1126/Scitranslmed.Aaf6812  0.715
2016 Elphinstone RE, Conroy AL, Hawkes M, Hermann L, Namasopo S, Warren HS, John CC, Liles WC, Kain KC. Alterations in systemic extracellular heme and hemopexin are associated with adverse clinical outcomes in Ugandan children with severe malaria. The Journal of Infectious Diseases. PMID 27515862 DOI: 10.1093/Infdis/Jiw357  0.704
2016 Conroy AL, Hawkes M, Elphinstone RE, Morgan C, Hermann L, Barker KR, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC. Acute Kidney Injury Is Common in Pediatric Severe Malaria and Is Associated With Increased Mortality. Open Forum Infectious Diseases. 3: ofw046. PMID 27186577 DOI: 10.1093/Ofid/Ofw046  0.685
2016 Ayi K, Lu Z, Serghides L, Ho JM, Wang JC, Liles WC, Kain KC. CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-infected Erythrocytes and Clearance of Malaria in vivo. Infection and Immunity. PMID 27091932 DOI: 10.1128/Iai.01426-15  0.65
2016 Turnbull H, Conroy A, Opoka RO, Namasopo S, Kain KC, Hawkes M. Solar-powered oxygen delivery: proof of concept. The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease. 20: 696-703. PMID 27084827 DOI: 10.5588/ijtld.15.0796  0.585
2016 Barker KR, Conroy AL, Hawkes M, Murphy H, Pandey P, Kain KC. Biomarkers of hypoxia, endothelial and circulatory dysfunction among climbers in Nepal with AMS and HAPE: a prospective case-control study. Journal of Travel Medicine. 23. PMID 26984355 DOI: 10.1093/Jtm/Taw005  0.642
2016 Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, et al. Gene control of tyrosine kinase TIE2 and vascular manifestations of infections. Proceedings of the National Academy of Sciences of the United States of America. PMID 26884170 DOI: 10.1073/Pnas.1519467113  0.358
2016 Graham SM, Chen J, Chung DW, Barker KR, Conroy AL, Hawkes MT, Namasopo S, Kain KC, López JA, Liles WC. Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial. Malaria Journal. 15: 56. PMID 26830467 DOI: 10.1186/S12936-016-1106-Z  0.71
2016 Hahn WO, Harju-Baker S, Erdman LK, Krudsood S, Kain KC, Wurfel MM, Liles WC. A common TLR1 polymorphism is associated with higher parasitaemia in a Southeast Asian population with Plasmodium falciparum malaria. Malaria Journal. 15: 12. PMID 26738805 DOI: 10.1186/S12936-015-1071-Y  0.762
2015 McDonald CR, Tran V, Kain KC. Complement Activation in Placental Malaria. Frontiers in Microbiology. 6: 1460. PMID 26733992 DOI: 10.3389/Fmicb.2015.01460  0.396
2015 Elphinstone RE, Riley F, Lin T, Higgins S, Dhabangi A, Musoke C, Cserti-Gazdewich C, Regan RF, Warren HS, Kain KC. Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case-control study of Ugandan children. Malaria Journal. 14: 511. PMID 26691827 DOI: 10.1186/S12936-015-1028-1  0.402
2015 Hawkes MT, Conroy AL, Opoka RO, Hermann L, Thorpe KE, McDonald C, Kim H, Higgins S, Namasopo S, John C, Miller C, Liles WC, Kain KC. Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial. Malaria Journal. 14: 421. PMID 26510464 DOI: 10.1186/S12936-015-0946-2  0.714
2015 Mikacenic C, Hahn WO, Price BL, Harju-Baker S, Katz R, Kain KC, Himmelfarb J, Liles WC, Wurfel MM. Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness. Plos One. 10: e0141251. PMID 26492036 DOI: 10.1371/Journal.Pone.0141251  0.334
2015 McDonald CR, Cahill LS, Ho KT, Yang J, Kim H, Silver KL, Ward PA, Mount HT, Liles WC, Sled JG, Kain KC. Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway. Plos Pathogens. 11: e1005140. PMID 26402732 DOI: 10.1371/Journal.Ppat.1005140  0.317
2015 Erdman LK, D'Acremont V, Hayford K, Rajwans N, Kilowoko M, Kyungu E, Hongoa P, Alamo L, Streiner DL, Genton B, Kain KC. Biomarkers of Host Response Predict Primary End-Point Radiological Pneumonia in Tanzanian Children with Clinical Pneumonia: A Prospective Cohort Study. Plos One. 10: e0137592. PMID 26366571 DOI: 10.1371/Journal.Pone.0137592  0.732
2015 Conroy AL, Gélvez M, Hawkes M, Rajwans N, Tran V, Liles WC, Villar-Centeno LA, Kain KC. Host biomarkers are associated with progression to dengue haemorrhagic fever: a nested case-control study. International Journal of Infectious Diseases : Ijid : Official Publication of the International Society For Infectious Diseases. 40: 45-53. PMID 26255888 DOI: 10.1016/J.Ijid.2015.07.027  0.683
2015 McDonald CR, Darling AM, Conroy AL, Tran V, Cabrera A, Liles WC, Wang M, Aboud S, Urassa W, Fawzi WW, Kain KC. Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women. Plos One. 10: e0134619. PMID 26247200 DOI: 10.1371/Journal.Pone.0134619  0.539
2015 Nyende S, Conroy A, Opoka RO, Namasopo S, Kain KC, Mpimbaza A, Bhargava R, Hawkes M. Solar-powered oxygen delivery: study protocol for a randomized controlled trial. Trials. 16: 297. PMID 26156116 DOI: 10.1186/S13063-015-0814-Y  0.645
2015 Hawkes M, Conroy AL, Opoka RO, Namasopo S, Zhong K, Liles WC, John CC, Kain KC. Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013. Emerging Infectious Diseases. 21: 1237-9. PMID 26079933 DOI: 10.3201/Eid2107.150213  0.698
2015 Conroy AL, Hawkes M, Hayford K, Namasopo S, Opoka RO, John CC, Liles WC, Kain KC. Prospective validation of pediatric disease severity scores to predict mortality in Ugandan children presenting with malaria and non-malaria febrile illness. Critical Care (London, England). 19: 47. PMID 25879892 DOI: 10.1186/S13054-015-0773-4  0.693
2015 Boggild AK, Lau R, Reynaud D, Kain KC, Gerson M. Failure of atovaquone-proguanil malaria chemoprophylaxis in a traveler to Ghana Travel Medicine and Infectious Disease. 13: 89-93. PMID 25582377 DOI: 10.1016/J.Tmaid.2014.12.010  0.333
2015 Lee J, Krajden S, Graham C, Boggild AK, Pavenski K, Keystone JS, Kain KC. Severe delayed hemolysis associated with regulated parenteral antimalarial drug. Emerging Infectious Diseases. 21: 164-6. PMID 25531800 DOI: 10.3201/Eid2101.140147  0.346
2015 Serghides L, Finney CA, Ayi K, Loutfy M, Kain KC. Chronic HIV infection impairs nonopsonic phagocytosis of malaria parasites. Journal of Acquired Immune Deficiency Syndromes (1999). 68: 128-32. PMID 25415293 DOI: 10.1097/Qai.0000000000000427  0.678
2014 Sagara I, Oduro AR, Mulenga M, Dieng Y, Ogutu B, Tiono AB, Mugyenyi P, Sie A, Wasunna M, Kain KC, Djimdé AA, Sarkar S, Chandra R, Robbins J, Dunne MW. Efficacy and safety of a combination of azithromycin and chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria in two multi-country randomised clinical trials in African adults. Malaria Journal. 13: 458. PMID 25425434 DOI: 10.1186/1475-2875-13-458  0.334
2014 Hawkes M, Conroy AL, Kain KC. Spread of artemisinin resistance in malaria. The New England Journal of Medicine. 371: 1944-5. PMID 25390755 DOI: 10.1056/Nejmc1410735  0.717
2014 Evans AB, Kulik D, Banerji A, Boggild A, Kain KC, Abdelhaleem M, Morris SK. Imported pediatric malaria at the Hospital for Sick Children, Toronto, Canada: a 16 year review. Bmc Pediatrics. 14: 251. PMID 25281037 DOI: 10.1186/1471-2431-14-251  0.389
2014 Cabrera A, Neculai D, Kain KC. CD36 and malaria: friends or foes? A decade of data provides some answers. Trends in Parasitology. 30: 436-44. PMID 25113859 DOI: 10.1016/J.Pt.2014.07.006  0.305
2014 Erdman LK, Petes C, Lu Z, Dhabangi A, Musoke C, Cserti-Gazdewich CM, Lee CG, Liles WC, Elias JA, Kain KC. Chitinase 3-like 1 is induced by Plasmodium falciparum malaria and predicts outcome of cerebral malaria and severe malarial anaemia in a case-control study of African children. Malaria Journal. 13: 279. PMID 25047113 DOI: 10.1186/1475-2875-13-279  0.786
2014 Odolini S, Gautret P, Kain KC, Smith K, Leder K, Jensenius M, Coyle CM, Castelli F, Matteelli A. Imported Plasmodium vivax malaria ex Pakistan. Journal of Travel Medicine. 21: 314-7. PMID 24889386 DOI: 10.1111/Jtm.12134  0.387
2014 Darling AM, McDonald CR, Conroy AL, Hayford KT, Liles WC, Wang M, Aboud S, Urassa WS, Kain KC, Fawzi WW. Angiogenic and inflammatory biomarkers in midpregnancy and small-for-gestational-age outcomes in Tanzania. American Journal of Obstetrics and Gynecology. 211: 509.e1-8. PMID 24881826 DOI: 10.1016/J.Ajog.2014.05.032  0.523
2014 Mendelson M, Han PV, Vincent P, von Sonnenburg F, Cramer JP, Loutan L, Kain KC, Parola P, Hagmann S, Gkrania-Klotsas E, Sotir M, Schlagenhauf P. Regional variation in travel-related illness acquired in Africa, March 1997-May 2011. Emerging Infectious Diseases. 20: 532-41. PMID 24655358 DOI: 10.3201/Eid2004.131128  0.337
2014 Serghides L, McDonald CR, Lu Z, Friedel M, Cui C, Ho KT, Mount HT, Sled JG, Kain KC. PPARγ agonists improve survival and neurocognitive outcomes in experimental cerebral malaria and induce neuroprotective pathways in human malaria. Plos Pathogens. 10: e1003980. PMID 24603727 DOI: 10.1371/Journal.Ppat.1003980  0.65
2014 Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, Kain KC. Performance of point-of-care diagnostics for glucose, lactate, and hemoglobin in the management of severe malaria in a resource-constrained hospital in Uganda. The American Journal of Tropical Medicine and Hygiene. 90: 605-8. PMID 24591431 DOI: 10.4269/Ajtmh.13-0689  0.673
2014 Showler AJ, Wilson ME, Kain KC, Boggild AK. Parasitic diseases in travelers: a focus on therapy. Expert Review of Anti-Infective Therapy. 12: 497-521. PMID 24579746 DOI: 10.1586/14787210.2014.892827  0.405
2014 Hawkes M, Conroy AL, Opoka RO, Namasopo S, Liles WC, John CC, Kain KC. Use of a three-band HRP2/pLDH combination rapid diagnostic test increases diagnostic specificity for falciparum malaria in Ugandan children. Malaria Journal. 13: 43. PMID 24484540 DOI: 10.1186/1475-2875-13-43  0.686
2014 Conroy AL, Gélvez M, Hawkes M, Rajwans N, Liles WC, Villar-Centeno LA, Kain KC. Host biomarkers distinguish dengue from leptospirosis in Colombia: a case-control study. Bmc Infectious Diseases. 14: 35. PMID 24444080 DOI: 10.1186/1471-2334-14-35  0.684
2014 Liles WC, Kain KC. Endothelial activation and dysfunction in the pathogenesis of microvascular obstruction in severe malaria--a viable target for therapeutic adjunctive intervention. The Journal of Infectious Diseases. 210: 163-4. PMID 24443542 DOI: 10.1093/Infdis/Jiu035  0.308
2014 Kim H, Darwish I, Monroy MF, Prockop DJ, Liles WC, Kain KC. Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. Bmc Immunology. 15: 1. PMID 24423010 DOI: 10.1186/1471-2172-15-1  0.309
2014 Cressman AM, McDonald CR, Silver K, Kain KC, Piquette-Miller M. Malaria infection alters the expression of hepatobiliary and placental drug transporters in pregnant mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 603-10. PMID 24281836 DOI: 10.1124/Dmd.113.053983  0.367
2014 Chege D, Higgins SJ, McDonald CR, Shahabi K, Huibner S, Kain T, Kain D, Kim CJ, Leung N, Amin M, Geddes K, Serghides L, Philpott DJ, Kimani J, Gray-Owen S, ... Kain KC, et al. Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae. Journal of Acquired Immune Deficiency Syndromes (1999). 65: 517-25. PMID 24256632 DOI: 10.1097/Qai.0000000000000056  0.638
2014 Kim H, Erdman LK, Lu Z, Serghides L, Zhong K, Dhabangi A, Musoke C, Gerard C, Cserti-Gazdewich C, Liles WC, Kain KC. Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria. Infection and Immunity. 82: 371-9. PMID 24191300 DOI: 10.1128/Iai.01246-13  0.794
2013 Yi TJ, Walmsley S, Szadkowski L, Raboud J, Rajwans N, Shannon B, Kumar S, Kain KC, Kaul R, Tan DH. A randomized controlled pilot trial of valacyclovir for attenuating inflammation and immune activation in HIV/herpes simplex virus 2-coinfected adults on suppressive antiretroviral therapy. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 57: 1331-8. PMID 23946220 DOI: 10.1093/Cid/Cit539  0.312
2013 Hawkes M, Elphinstone RE, Conroy AL, Kain KC. Contrasting pediatric and adult cerebral malaria: the role of the endothelial barrier. Virulence. 4: 543-55. PMID 23924893 DOI: 10.4161/Viru.25949  0.72
2013 McDonald CR, Elphinstone RE, Kain KC. The impact of placental malaria on neurodevelopment of exposed infants: a role for the complement system? Trends in Parasitology. 29: 213-9. PMID 23562777 DOI: 10.1016/J.Pt.2013.03.005  0.332
2013 Higgins SJ, Xing K, Kim H, Kain DC, Wang F, Dhabangi A, Musoke C, Cserti-Gazdewich CM, Tracey KJ, Kain KC, Liles WC. Systemic release of high mobility group box 1 (HMGB1) protein is associated with severe and fatal Plasmodium falciparum malaria. Malaria Journal. 12: 105. PMID 23506269 DOI: 10.1186/1475-2875-12-105  0.458
2013 Conroy AL, Silver KL, Zhong K, Rennie M, Ward P, Sarma JV, Molyneux ME, Sled J, Fletcher JF, Rogerson S, Kain KC. Complement activation and the resulting placental vascular insufficiency drives fetal growth restriction associated with placental malaria. Cell Host & Microbe. 13: 215-26. PMID 23414761 DOI: 10.1016/J.Chom.2013.01.010  0.547
2013 Crandall IE, Wasilewski E, Bello AM, Mohmmed A, Malhotra P, Pai EF, Kain KC, Kotra LP. Antimalarial activities of 6-iodouridine and its prodrugs and potential for combination therapy. Journal of Medicinal Chemistry. 56: 2348-58. PMID 23410043 DOI: 10.1021/Jm301678J  0.328
2013 Finney CA, Ayi K, Wasmuth JD, Sheth PM, Kaul R, Loutfy M, Kain KC, Serghides L. HIV infection deregulates Tim-3 expression on innate cells: combination antiretroviral therapy results in partial restoration. Journal of Acquired Immune Deficiency Syndromes (1999). 63: 161-7. PMID 23314411 DOI: 10.1097/Qai.0B013E318285Cf13  0.616
2013 Finney CA, Ayi K, Wasmuth JD, Sheth PM, Kaul R, Loutfy MR, Kain KC, Serghides L. HIV infection deregulates innate immunity to malaria despite combination antiretroviral therapy. Aids (London, England). 27: 325-35. PMID 23291537 DOI: 10.1097/Qad.0B013E32835B3Dfa  0.648
2013 Elphinstone RE, Higgins SJ, Kain KC. Prevention of Malaria in Travelers: Bite Avoidance and Chemoprophylactic Measures Current Treatment Options in Infectious Diseases. 6: 47-57. DOI: 10.1007/S40506-013-0005-X  0.355
2012 Conroy AL, McDonald CR, Kain KC. Malaria in pregnancy: diagnosing infection and identifying fetal risk. Expert Review of Anti-Infective Therapy. 10: 1331-42. PMID 23241190 DOI: 10.1586/Eri.12.123  0.6
2012 Wolofsky KT, Ayi K, Branch DR, Hult AK, Olsson ML, Liles WC, Cserti-Gazdewich CM, Kain KC. ABO blood groups influence macrophage-mediated phagocytosis of Plasmodium falciparum-infected erythrocytes. Plos Pathogens. 8: e1002942. PMID 23071435 DOI: 10.1371/Journal.Ppat.1002942  0.366
2012 Wuerz T, Kane JB, Boggild AK, Krajden S, Keystone JS, Fuksa M, Kain KC, Warren R, Kempston J, Anderson J. A review of amoebic liver abscess for clinicians in a nonendemic setting. Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. 26: 729-33. PMID 23061067 DOI: 10.1155/2012/852835  0.313
2012 Neuberger A, Zhong K, Kain KC, Schwartz E. Lack of evidence for chloroquine-resistant Plasmodium falciparum malaria, Leogane, Haiti. Emerging Infectious Diseases. 18: 1487-9. PMID 22932030 DOI: 10.3201/Eid1809.120605  0.333
2012 Miller C, Miller M, McMullin B, Regev G, Serghides L, Kain K, Road J, Av-Gay Y. A phase I clinical study of inhaled nitric oxide in healthy adults. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. 11: 324-31. PMID 22520076 DOI: 10.1016/J.Jcf.2012.01.003  0.609
2012 Conroy AL, Glover SJ, Hawkes M, Erdman LK, Seydel KB, Taylor TE, Molyneux ME, Kain KC. Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria: a retrospective case-control study*. Critical Care Medicine. 40: 952-9. PMID 22343839 DOI: 10.1097/Ccm.0B013E3182373157  0.814
2012 Berghout J, Higgins S, Loucoubar C, Sakuntabhai A, Kain KC, Gros P. Genetic diversity in human erythrocyte pyruvate kinase. Genes and Immunity. 13: 98-102. PMID 21833022 DOI: 10.1038/Gene.2011.54  0.311
2012 Conroy AL, Kain KC. Low angiopoietin-1 as a predisposing factor for cerebral vasospasm in cerebral malaria Critical Care Medicine. 40: 3334. DOI: 10.1097/Ccm.0B013E318270E403  0.552
2011 Conroy AL, Liles WC, Molyneux ME, Rogerson SJ, Kain KC. Performance characteristics of combinations of host biomarkers to identify women with occult placental malaria: a case-control study from Malawi. Plos One. 6: e28540. PMID 22174834 DOI: 10.1371/Journal.Pone.0028540  0.606
2011 Serghides L, Kim H, Lu Z, Kain DC, Miller C, Francis RC, Liles WC, Zapol WM, Kain KC. Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria. Plos One. 6: e27714. PMID 22110737 DOI: 10.1371/Journal.Pone.0027714  0.681
2011 Silver KL, Conroy AL, Leke RG, Leke RJ, Gwanmesia P, Molyneux ME, Taylor DW, Wallace DT, Rogerson SJ, Kain KC. Circulating soluble endoglin levels in pregnant women in Cameroon and Malawi--associations with placental malaria and fetal growth restriction. Plos One. 6: e24985. PMID 21966395 DOI: 10.1371/Journal.Pone.0024985  0.587
2011 Higgins SJ, Kain KC, Liles WC. Immunopathogenesis of falciparum malaria: implications for adjunctive therapy in the management of severe and cerebral malaria. Expert Review of Anti-Infective Therapy. 9: 803-19. PMID 21905788 DOI: 10.1586/Eri.11.96  0.438
2011 Erdman LK, Kain KC. Taking the sting out of malaria. Immunity. 35: 149-51. PMID 21867921 DOI: 10.1016/J.Immuni.2011.08.002  0.741
2011 Hawkes M, Opoka RO, Namasopo S, Miller C, Thorpe KE, Lavery JV, Conroy AL, Liles WC, John CC, Kain KC. Inhaled nitric oxide for the adjunctive therapy of severe malaria: protocol for a randomized controlled trial. Trials. 12: 176. PMID 21752262 DOI: 10.1186/1745-6215-12-176  0.716
2011 Hawkes M, Opoka RO, Namasopo S, Miller C, Conroy AL, Serghides L, Kim H, Thampi N, Liles WC, John CC, Kain KC. Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale. Medical Hypotheses. 77: 437-44. PMID 21745716 DOI: 10.1016/J.Mehy.2011.06.003  0.783
2011 Hills T, Srivastava A, Ayi K, Wernimont AK, Kain K, Waters AP, Hui R, Pizarro JC. Characterization of a new phosphatase from Plasmodium. Molecular and Biochemical Parasitology. 179: 69-79. PMID 21689687 DOI: 10.1016/J.Molbiopara.2011.06.001  0.347
2011 Finney CA, Hawkes CA, Kain DC, Dhabangi A, Musoke C, Cserti-Gazdewich C, Oravecz T, Liles WC, Kain KC. S1P is associated with protection in human and experimental cerebral malaria. Molecular Medicine (Cambridge, Mass.). 17: 717-25. PMID 21556483 DOI: 10.2119/Molmed.2010.00214  0.378
2011 Conroy AL, McDonald CR, Silver KL, Liles WC, Kain KC. Complement activation: a critical mediator of adverse fetal outcomes in placental malaria? Trends in Parasitology. 27: 294-9. PMID 21493146 DOI: 10.1016/J.Pt.2011.02.005  0.573
2011 Kim H, Higgins S, Liles WC, Kain KC. Endothelial activation and dysregulation in malaria: a potential target for novel therapeutics. Current Opinion in Hematology. 18: 177-85. PMID 21423010 DOI: 10.1097/Moh.0B013E328345A4Cf  0.376
2011 Erdman LK, Dhabangi A, Musoke C, Conroy AL, Hawkes M, Higgins S, Rajwans N, Wolofsky KT, Streiner DL, Liles WC, Cserti-Gazdewich CM, Kain KC. Combinations of host biomarkers predict mortality among Ugandan children with severe malaria: a retrospective case-control study. Plos One. 6: e17440. PMID 21364762 DOI: 10.1371/Journal.Pone.0017440  0.818
2011 Ricciuto DR, dos Santos CC, Hawkes M, Toltl LJ, Conroy AL, Rajwans N, Lafferty EI, Cook DJ, Fox-Robichaud A, Kahnamoui K, Kain KC, Liaw PC, Liles WC. Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis. Critical Care Medicine. 39: 702-10. PMID 21242795 DOI: 10.1097/Ccm.0B013E318206D285  0.679
2011 Silver KL, Conroy AL, Leke RGF, Leke RJI, Gwanmesia P, Molyneux ME, Wallace Taylor D, Rogerson SJ, Kain KC. Correction: Circulating Soluble Endoglin Levels in Pregnant Women in Cameroon and Malawi—Associations with Placental Malaria and Fetal Growth Restriction Plos One. 6. DOI: 10.1371/annotation/e9946f72-821d-45ea-bcd4-3fa3ff89a5fe  0.497
2010 Conroy AL, Phiri H, Hawkes M, Glover S, Mallewa M, Seydel KB, Taylor TE, Molyneux ME, Kain KC. Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study. Plos One. 5: e15291. PMID 21209923 DOI: 10.1371/Journal.Pone.0015291  0.688
2010 Hawkes M, Li X, Crockett M, Diassiti A, Finney C, Min-Oo G, Liles WC, Liu J, Kain KC. CD36 deficiency attenuates experimental mycobacterial infection. Bmc Infectious Diseases. 10: 299. PMID 20950462 DOI: 10.1186/1471-2334-10-299  0.547
2010 Labbé K, Miu J, Yeretssian G, Serghides L, Tam M, Finney CA, Erdman LK, Goulet ML, Kain KC, Stevenson MM, Saleh M. Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kappaB signaling. Journal of Immunology (Baltimore, Md. : 1950). 185: 5495-502. PMID 20876354 DOI: 10.4049/Jimmunol.1002517  0.797
2010 Cserti-Gazdewich CM, Dzik WH, Erdman L, Ssewanyana I, Dhabangi A, Musoke C, Kain KC. Combined measurement of soluble and cellular ICAM-1 among children with Plasmodium falciparum malaria in Uganda. Malaria Journal. 9: 233. PMID 20712868 DOI: 10.1186/1475-2875-9-233  0.773
2010 Finney CA, Lu Z, Hawkes M, Yeh WC, Liles WC, Kain KC. Divergent roles of IRAK4-mediated innate immune responses in two experimental models of severe malaria. The American Journal of Tropical Medicine and Hygiene. 83: 69-74. PMID 20595480 DOI: 10.4269/Ajtmh.2010.09-0753  0.616
2010 Wang F, Lu Z, Hawkes M, Yang H, Kain KC, Liles WC. Fas (CD95) induces rapid, TLR4/IRAK4-dependent release of pro-inflammatory HMGB1 from macrophages. Journal of Inflammation (London, England). 7: 30. PMID 20565784 DOI: 10.1186/1476-9255-7-30  0.52
2010 Silver KL, Higgins SJ, McDonald CR, Kain KC. Complement driven innate immune response to malaria: fuelling severe malarial diseases. Cellular Microbiology. 12: 1036-45. PMID 20545944 DOI: 10.1111/J.1462-5822.2010.01492.X  0.415
2010 Hawkes M, Li X, Crockett M, Diassiti A, Liles WC, Liu J, Kain KC. Malaria exacerbates experimental mycobacterial infection in vitro and in vivo. Microbes and Infection / Institut Pasteur. 12: 864-74. PMID 20542132 DOI: 10.1016/J.Micinf.2010.05.013  0.621
2010 Min-Oo G, Ayi K, Bongfen SE, Tam M, Radovanovic I, Gauthier S, Santiago H, Rothfuchs AG, Roffê E, Sher A, Mullick A, Fortin A, Stevenson MM, Kain KC, Gros P. Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium. Experimental Parasitology. 125: 315-24. PMID 20219464 DOI: 10.1016/J.Exppara.2010.02.009  0.405
2010 Silver KL, Zhong K, Leke RG, Taylor DW, Kain KC. Dysregulation of angiopoietins is associated with placental malaria and low birth weight. Plos One. 5: e9481. PMID 20208992 DOI: 10.1371/Journal.Pone.0009481  0.349
2009 Conroy AL, Lafferty EI, Lovegrove FE, Krudsood S, Tangpukdee N, Liles WC, Kain KC. Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria. Malaria Journal. 8: 295. PMID 20003529 DOI: 10.1186/1475-2875-8-295  0.581
2009 Erdman LK, Cosio G, Helmers AJ, Gowda DC, Grinstein S, Kain KC. CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria. Journal of Immunology (Baltimore, Md. : 1950). 183: 6452-9. PMID 19864601 DOI: 10.4049/Jimmunol.0901374  0.725
2009 Helmers AJ, Gowda DC, Kain KC, Liles WC. Statins fail to improve outcome in experimental cerebral malaria and potentiate Toll-like receptor-mediated cytokine production by murine macrophages. The American Journal of Tropical Medicine and Hygiene. 81: 631-7. PMID 19815878 DOI: 10.4269/Ajtmh.2009.09-0204  0.394
2009 Ayi K, Liles WC, Gros P, Kain KC. Adenosine triphosphate depletion of erythrocytes simulates the phenotype associated with pyruvate kinase deficiency and confers protection against Plasmodium falciparum in vitro. The Journal of Infectious Diseases. 200: 1289-99. PMID 19743919 DOI: 10.1086/605843  0.351
2009 Boggild AK, Krudsood S, Patel SN, Serghides L, Tangpukdee N, Katz K, Wilairatana P, Liles WC, Looareesuwan S, Kain KC. Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 49: 841-9. PMID 19673614 DOI: 10.1086/605431  0.678
2009 Finney CA, Lu Z, LeBourhis L, Philpott DJ, Kain KC. Disruption of Nod-like receptors alters inflammatory response to infection but does not confer protection in experimental cerebral malaria. The American Journal of Tropical Medicine and Hygiene. 80: 718-22. PMID 19407112 DOI: 10.4269/Ajtmh.2009.80.718  0.407
2009 Serghides L, Patel SN, Ayi K, Lu Z, Gowda DC, Liles WC, Kain KC. Rosiglitazone modulates the innate immune response to Plasmodium falciparum infection and improves outcome in experimental cerebral malaria. The Journal of Infectious Diseases. 199: 1536-45. PMID 19392627 DOI: 10.1086/598222  0.701
2009 Conroy A, Serghides L, Finney C, Owino SO, Kumar S, Gowda DC, Liles WC, Moore JM, Kain KC. C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. Plos One. 4: e4953. PMID 19308263 DOI: 10.1371/Journal.Pone.0004953  0.71
2009 Lovegrove FE, Tangpukdee N, Opoka RO, Lafferty EI, Rajwans N, Hawkes M, Krudsood S, Looareesuwan S, John CC, Liles WC, Kain KC. Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. Plos One. 4: e4912. PMID 19300530 DOI: 10.1371/Journal.Pone.0004912  0.597
2009 Perrault SD, Hajek J, Zhong K, Owino SO, Sichangi M, Smith G, Shi YP, Moore JM, Kain KC. Human immunodeficiency virus co-infection increases placental parasite density and transplacental malaria transmission in Western Kenya. The American Journal of Tropical Medicine and Hygiene. 80: 119-25. PMID 19141849 DOI: 10.4269/Ajtmh.2009.80.119  0.398
2008 Helmers AJ, Lovegrove FE, Harlan JM, Kain KC, Liles WC. Failure of two distinct anti-apoptotic approaches to reduce mortality in experimental cerebral malaria. The American Journal of Tropical Medicine and Hygiene. 79: 823-5. PMID 19052286 DOI: 10.4269/Ajtmh.2008.79.823  0.395
2008 Erdman LK, Finney CA, Liles WC, Kain KC. Inflammatory pathways in malaria infection: TLRs share the stage with other components of innate immunity. Molecular and Biochemical Parasitology. 162: 105-11. PMID 18804125 DOI: 10.1016/J.Molbiopara.2008.08.006  0.763
2008 Lovegrove FE, Peña-Castillo L, Liles WC, Hughes TR, Kain KC. Plasmodium falciparum shows transcriptional versatility within the human host. Trends in Parasitology. 24: 288-91. PMID 18538633 DOI: 10.1016/J.Pt.2008.04.004  0.364
2008 Lovegrove FE, Gharib SA, Peña-Castillo L, Patel SN, Ruzinski JT, Hughes TR, Liles WC, Kain KC. Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model. Plos Pathogens. 4: e1000068. PMID 18483551 DOI: 10.1371/Journal.Ppat.1000068  0.391
2008 Rose GW, Suh KN, Kain KC, Le Saux N, McCarthy AE. Atovaquone-proguanil resistance in imported falciparum malaria in a young child. The Pediatric Infectious Disease Journal. 27: 567-9. PMID 18434932 DOI: 10.1097/Inf.0B013E318167918D  0.314
2008 Patel SN, Berghout J, Lovegrove FE, Ayi K, Conroy A, Serghides L, Min-oo G, Gowda DC, Sarma JV, Rittirsch D, Ward PA, Liles WC, Gros P, Kain KC. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. The Journal of Experimental Medicine. 205: 1133-43. PMID 18426986 DOI: 10.1084/Jem.20072248  0.692
2008 Ayi K, Min-Oo G, Serghides L, Crockett M, Kirby-Allen M, Quirt I, Gros P, Kain KC. Pyruvate kinase deficiency and malaria. The New England Journal of Medicine. 358: 1805-10. PMID 18420493 DOI: 10.1056/Nejmoa072464  0.665
2008 Erdman LK, Kain KC. Molecular diagnostic and surveillance tools for global malaria control. Travel Medicine and Infectious Disease. 6: 82-99. PMID 18342279 DOI: 10.1016/J.Tmaid.2007.10.001  0.761
2008 Bello AM, Poduch E, Liu Y, Wei L, Crandall I, Wang X, Dyanand C, Kain KC, Pai EF, Kotra LP. Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase. Journal of Medicinal Chemistry. 51: 439-48. PMID 18189347 DOI: 10.1021/Jm7010673  0.303
2008 Erdman L, Kain KC. STIMULATION OF TOLL-LIKE RECEPTOR 2 BY PLASMODIUMFALCIPARUM GLYCOSYLPHOSPHATIDYLINOSITOLS ENHANCES MACROPHAGE INTERNALIZATION OF PARASITIZED AND UNINFECTED ERYTHROCYTES Clinical & Investigative Medicine. 31: 9. DOI: 10.25011/Cim.V31I4.4801  0.754
2007 Lovegrove FE, Gharib SA, Patel SN, Hawkes CA, Kain KC, Liles WC. Expression microarray analysis implicates apoptosis and interferon-responsive mechanisms in susceptibility to experimental cerebral malaria. The American Journal of Pathology. 171: 1894-903. PMID 17991715 DOI: 10.2353/Ajpath.2007.070630  0.352
2007 Hawkes M, Kain KC. Advances in malaria diagnosis. Expert Review of Anti-Infective Therapy. 5: 485-95. PMID 17547512 DOI: 10.1586/14787210.5.3.485  0.564
2007 Keen J, Serghides L, Ayi K, Patel SN, Ayisi J, van Eijk A, Steketee R, Udhayakumar V, Kain KC. HIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites. Plos Medicine. 4: e181. PMID 17535103 DOI: 10.1371/Journal.Pmed.0040181  0.628
2007 Wilson ME, Weld LH, Boggild A, Keystone JS, Kain KC, von Sonnenburg F, Schwartz E. Fever in returned travelers: results from the GeoSentinel Surveillance Network. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 44: 1560-8. PMID 17516399 DOI: 10.1086/518173  0.352
2007 Crockett M, Kain KC. Tafenoquine: a promising new antimalarial agent. Expert Opinion On Investigational Drugs. 16: 705-15. PMID 17461742 DOI: 10.1517/13543784.16.5.705  0.384
2007 Krudsood S, Patel SN, Tangpukdee N, Thanachartwet W, Leowattana W, Pornpininworakij K, Boggild AK, Looareesuwan S, Kain KC. Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand. The American Journal of Tropical Medicine and Hygiene. 76: 655-8. PMID 17426165 DOI: 10.4269/Ajtmh.2007.76.655  0.358
2007 Patel SN, Lu Z, Ayi K, Serghides L, Gowda DC, Kain KC. Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo. Journal of Immunology (Baltimore, Md. : 1950). 178: 3954-61. PMID 17339496 DOI: 10.4049/Jimmunol.178.6.3954  0.668
2007 Boggild AK, Parise ME, Lewis LS, Kain KC. Atovaquone-proguanil: report from the CDC expert meeting on malaria chemoprophylaxis (II). The American Journal of Tropical Medicine and Hygiene. 76: 208-23. PMID 17297027 DOI: 10.4269/Ajtmh.2007.76.208  0.304
2007 Erdman L, Cosio G, Patel SN, Grinstein S, Kain KC. Innate inflammatory and phagocytic responses to Plasmodium falciparum: linked processes or molecularly discrete pathways?s Clinical & Investigative Medicine. 30: 81. DOI: 10.25011/Cim.V30I4.2851  0.743
2007 Finney CAM, Liles WC, Kain KC. Severe malaria and host response: time for a paradigm shift in therapeutic strategies to improve clinical outcome Drug Discovery Today: Disease Mechanisms. 4: 207-214. DOI: 10.1016/J.Ddmec.2008.02.009  0.393
2007 Silver KL, Kain KC, Liles WC. Endothelial activation and dysregulation: A common pathway to organ injury in infectious diseases associated with systemic inflammation Drug Discovery Today: Disease Mechanisms. 4: 215-222. DOI: 10.1016/J.Ddmec.2008.01.002  0.311
2006 Lovegrove FE, Peña-Castillo L, Mohammad N, Liles WC, Hughes TR, Kain KC. Simultaneous host and parasite expression profiling identifies tissue-specific transcriptional programs associated with susceptibility or resistance to experimental cerebral malaria. Bmc Genomics. 7: 295. PMID 17118208 DOI: 10.1186/1471-2164-7-295  0.389
2006 Lu Z, Serghides L, Patel SN, Degousee N, Rubin BB, Krishnegowda G, Gowda DC, Karin M, Kain KC. Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model. Journal of Immunology (Baltimore, Md. : 1950). 177: 6344-52. PMID 17056565 DOI: 10.4049/Jimmunol.177.9.6344  0.644
2006 Leder K, Tong S, Weld L, Kain KC, Wilder-Smith A, von Sonnenburg F, Black J, Brown GV, Torresi J. Illness in travelers visiting friends and relatives: a review of the GeoSentinel Surveillance Network. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 43: 1185-93. PMID 17029140 DOI: 10.1086/507893  0.317
2006 Stauffer WM, Magill A, Kain KC. Parasitic central nervous system infections in immunocompromised hosts: clarification of malaria diagnosis. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 43: 114-5; author reply . PMID 16758433 DOI: 10.1086/504951  0.393
2006 Serghides L, Patel SN, Ayi K, Kain KC. Placental chondroitin sulfate A-binding malarial isolates evade innate phagocytic clearance. The Journal of Infectious Diseases. 194: 133-9. PMID 16741892 DOI: 10.1086/504721  0.65
2006 Boggild AK, Yohanna S, Keystone JS, Kain KC. Prospective analysis of parasitic infections in Canadian travelers and immigrants. Journal of Travel Medicine. 13: 138-44. PMID 16706944 DOI: 10.1111/J.1708-8305.2006.00032.X  0.394
2006 Farcas GA, Soeller R, Zhong K, Zahirieh A, Kain KC. Real-time polymerase chain reaction assay for the rapid detection and characterization of chloroquine-resistant Plasmodium falciparum malaria in returned travelers. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 42: 622-7. PMID 16447106 DOI: 10.1086/500134  0.386
2005 Patel SN, Kain KC. Atovaquone/proguanil for the prophylaxis and treatment of malaria. Expert Review of Anti-Infective Therapy. 3: 849-61. PMID 16307498 DOI: 10.1586/14787210.3.6.849  0.369
2005 Kuhn S, Gill MJ, Kain KC. Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to west Africa. The American Journal of Tropical Medicine and Hygiene. 72: 407-9. PMID 15827276 DOI: 10.4269/Ajtmh.2005.72.407  0.334
2005 Ayi K, Patel SN, Serghides L, Smith TG, Kain KC. Nonopsonic phagocytosis of erythrocytes infected with ring-stage Plasmodium falciparum. Infection and Immunity. 73: 2559-63. PMID 15784606 DOI: 10.1128/Iai.73.4.2559-2563.2005  0.64
2005 Pillai DR, Kain KC. Entamoeba histolytica: identification of a distinct beta2 integrin-like molecule with a potential role in cellular adherence. Experimental Parasitology. 109: 135-42. PMID 15713444 DOI: 10.1016/J.Exppara.2004.12.007  0.563
2005 Serghides L, Kain KC. Peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists have minimal effects on the interaction of endothelial cells with Plasmodium falciparum-infected erythrocytes. Infection and Immunity. 73: 1209-13. PMID 15664966 DOI: 10.1128/Iai.73.2.1209-1213.2005  0.63
2004 Mazzulli T, Kain K, Butany J. Severe acute respiratory syndrome: Overview with an emphasis on the Toronto experience Archives of Pathology and Laboratory Medicine. 128: 1346-1350. PMID 15578877 DOI: 10.1043/1543-2165(2004)128<1346:Sarsow>2.0.Co;2  0.304
2004 Elliott JH, O'Brien D, Leder K, Kitchener S, Schwartz E, Weld L, Brown GV, Kain KC, Torresi J. Imported Plasmodium vivax malaria: demographic and clinical features in nonimmune travelers. Journal of Travel Medicine. 11: 213-7. PMID 15541223 DOI: 10.2310/7060.2004.19004  0.41
2004 Boggild AK, Keystone JS, Kain KC. Tropical pulmonary eosinophilia: a case series in a setting of nonendemicity. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 39: 1123-8. PMID 15486834 DOI: 10.1086/423964  0.312
2004 Leder K, Black J, O'Brien D, Greenwood Z, Kain KC, Schwartz E, Brown G, Torresi J. Malaria in travelers: a review of the GeoSentinel surveillance network. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 39: 1104-12. PMID 15486832 DOI: 10.1086/424510  0.372
2004 Lim S, Katz K, Krajden S, Fuksa M, Keystone JS, Kain KC. Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management. Cmaj : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. 171: 479-84. PMID 15337730 DOI: 10.1503/Cmaj.1031698  0.338
2004 Smith TG, Kain KC. Inactivation of Plasmodium falciparum by photodynamic excitation of heme-cycle intermediates derived from delta-aminolevulinic acid. The Journal of Infectious Diseases. 190: 184-91. PMID 15195259 DOI: 10.1086/421503  0.379
2004 Suh KN, Kain KC, Keystone JS. Malaria. Cmaj : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. 170: 1693-702. PMID 15159369 DOI: 10.1503/cmaj.1030418  0.322
2004 Farcas GA, Zhong KJ, Mazzulli T, Kain KC. Evaluation of the RealArt Malaria LC real-time PCR assay for malaria diagnosis. Journal of Clinical Microbiology. 42: 636-8. PMID 14766829 DOI: 10.1128/Jcm.42.2.636-638.2004  0.357
2004 Alweis RL, DiRosario K, Conidi G, Kain KC, Olans R, Tully JL. Serial nosocomial transmission of Plasmodium falciparum malaria from patient to nurse to patient. Infection Control and Hospital Epidemiology. 25: 55-9. PMID 14756221 DOI: 10.1086/502293  0.318
2004 Patel SN, Serghides L, Smith TG, Febbraio M, Silverstein RL, Kurtz TW, Pravenec M, Kain KC. CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages. The Journal of Infectious Diseases. 189: 204-13. PMID 14722884 DOI: 10.1086/380764  0.626
2003 Farcas GA, Zhong KJ, Lovegrove FE, Graham CM, Kain KC. Evaluation of the Binax NOW ICT test versus polymerase chain reaction and microscopy for the detection of malaria in returned travelers. The American Journal of Tropical Medicine and Hygiene. 69: 589-92. PMID 14740873 DOI: 10.4269/Ajtmh.2003.69.6.0690589  0.391
2003 Ruebush TK, Zegarra J, Cairo J, Andersen EM, Green M, Pillai DR, Marquiño W, Huilca M, Arévalo E, Garcia C, Solary L, Kain KC. Chloroquine-resistant Plasmodium vivax malaria in Peru. The American Journal of Tropical Medicine and Hygiene. 69: 548-52. PMID 14695094 DOI: 10.4269/Ajtmh.2003.69.548  0.605
2003 Nathoo S, Serghides L, Kain KC. Effect of HIV-1 antiretroviral drugs on cytoadherence and phagocytic clearance of Plasmodium falciparum-parasitised erythrocytes. Lancet (London, England). 362: 1039-41. PMID 14522535 DOI: 10.1016/S0140-6736(03)14414-5  0.662
2003 Serghides L, Smith TG, Patel SN, Kain KC. CD36 and malaria: friends or foes? Trends in Parasitology. 19: 461-9. PMID 14519584 DOI: 10.1016/J.Pt.2003.08.006  0.674
2003 Schwartz E, Bujanover S, Kain KC. Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 37: 450-1. PMID 12884171 DOI: 10.1086/375599  0.316
2003 Forney JR, Wongsrichanalai C, Magill AJ, Craig LG, Sirichaisinthop J, Bautista CT, Miller RS, Ockenhouse CF, Kester KE, Aronson NE, Andersen EM, Quino-Ascurra HA, Vidal C, Moran KA, Murray CK, ... ... Kain KC, et al. Devices for rapid diagnosis of Malaria: evaluation of prototype assays that detect Plasmodium falciparum histidine-rich protein 2 and a Plasmodium vivax-specific antigen. Journal of Clinical Microbiology. 41: 2358-66. PMID 12791849 DOI: 10.1128/Jcm.41.6.2358-2366.2003  0.344
2003 Kain KC. Current status and replies to frequently posed questions on atovaquone plus proguanil (Malarone) for the prevention of malaria. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 17: 23-8. PMID 12785875 DOI: 10.2165/00063030-200317001-00006  0.378
2003 Kain KC. Atovaquone/proguanil: the need for family protection. Journal of Travel Medicine. 10: S8-12; discussion S2. PMID 12737754 DOI: 10.2310/7060.2003.35057  0.377
2003 Pillai DR, Hijar G, Montoya Y, Marouiño W, Ruebush TK, Wongsrichanalai C, Kain KC. Lack of prediction of mefloquine and mefloquine-artesunate treatment outcome by mutations in the Plasmodium falciparum multidrug resistance 1 (pfmdr1) gene for P. falciparum malaria in Peru. The American Journal of Tropical Medicine and Hygiene. 68: 107-10. PMID 12557835 DOI: 10.4269/Ajtmh.2003.68.107  0.576
2003 Labbé AC, Patel S, Crandall I, Kain KC. A molecular surveillance system for global patterns of drug resistance in imported malaria. Emerging Infectious Diseases. 9: 33-6. PMID 12533279 DOI: 10.3201/Eid0901.020121  0.338
2003 Smith TG, Serghides L, Patel SN, Febbraio M, Silverstein RL, Kain KC. CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum. Infection and Immunity. 71: 393-400. PMID 12496189 DOI: 10.1128/Iai.71.1.393-400.2003  0.643
2002 Smith TG, Ayi K, Serghides L, Mcallister CD, Kain KC. Innate immunity to malaria caused by Plasmodium falciparum. Clinical and Investigative Medicine. MéDecine Clinique Et Experimentale. 25: 262-72. PMID 12516999  0.667
2002 Richardson DC, Ciach M, Zhong KJ, Crandall I, Kain KC. Evaluation of the Makromed dipstick assay versus PCR for diagnosis of Plasmodium falciparum malaria in returned travelers. Journal of Clinical Microbiology. 40: 4528-30. PMID 12454146 DOI: 10.1128/Jcm.40.12.4528-4530.2002  0.375
2002 Loutfy MR, Wilson M, Keystone JS, Kain KC. Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area. The American Journal of Tropical Medicine and Hygiene. 66: 749-52. PMID 12224585 DOI: 10.4269/Ajtmh.2002.66.749  0.339
2002 Ohrt C, Purnomo, Sutamihardja MA, Tang D, Kain KC. Impact of microscopy error on estimates of protective efficacy in malaria-prevention trials. The Journal of Infectious Diseases. 186: 540-6. PMID 12195382 DOI: 10.1086/341938  0.311
2002 Kisilevsky R, Crandall I, Szarek WA, Bhat S, Tan C, Boudreau L, Kain KC. Short-chain aliphatic polysulfonates inhibit the entry of Plasmodium into red blood cells. Antimicrobial Agents and Chemotherapy. 46: 2619-26. PMID 12121942 DOI: 10.1128/Aac.46.8.2619-2626.2002  0.34
2002 Serghides L, Kain KC. Mechanism of protection induced by vitamin A in falciparum malaria. Lancet (London, England). 359: 1404-6. PMID 11978340 DOI: 10.1016/S0140-6736(02)08360-5  0.666
2002 Serghides L, Nathoo S, Walmsley S, Kain KC. CD36 deficiency induced by antiretroviral therapy. Aids (London, England). 16: 353-8. PMID 11834946 DOI: 10.1097/00002030-200202150-00006  0.618
2002 Kain K. Book Review: WHO Expert Committee on Malaria Tropical Doctor. 32: 191-191. DOI: 10.1177/004947550203200344  0.31
2002 Serghides L, Kain K. Paludisme: effet protecteur de la vitamine A Revue FrançAise Des Laboratoires. 2002: 15. DOI: 10.1016/s0338-9898(02)80387-0  0.524
2001 Pillai DR, Kobayashi S, Kain KC. Entamoeba dispar: molecular characterization of the galactose/N-acetyl-d-galactosamine lectin. Experimental Parasitology. 99: 226-34. PMID 11888250 DOI: 10.1006/Expr.2001.4672  0.536
2001 Labbé AC, Bualombai P, Pillai DR, Zhong KJ, Vanisaveth V, Hongvanthong B, Looareesuwan S, Kain KC. Molecular markers for chloroquine-resistant Plasmodium falciparum malaria in Thailand and Laos. Annals of Tropical Medicine and Parasitology. 95: 781-8. PMID 11784432 DOI: 10.1080/00034980120103414  0.587
2001 Labbé AC, Pillai DR, Hongvangthong B, Vanisaveth V, Pomphida S, Inkathone S, Hay Burgess DC, Kain KC. The performance and utility of rapid diagnostic assays for Plasmodium falciparum malaria in a field setting in the Lao People's Democratic Republic. Annals of Tropical Medicine and Parasitology. 95: 671-7. PMID 11784420 DOI: 10.1080/00034980120103243  0.592
2001 Berman JD, Nielsen R, Chulay JD, Dowler M, Kain KC, Kester KE, Williams J, Whelen AC, Shmuklarsky MJ. Causal prophylactic efficacy of atovaquone-proguanil (Malarone) in a human challenge model. Transactions of the Royal Society of Tropical Medicine and Hygiene. 95: 429-32. PMID 11579890 DOI: 10.1016/S0035-9203(01)90206-8  0.322
2001 Overbosch D, Schilthuis H, Bienzle U, Behrens RH, Kain KC, Clarke PD, Toovey S, Knobloch J, Nothdurft HD, Shaw D, Roskell NS, Chulay JD, Boraston S, Salzman J, Tessier D, et al. Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: Results from a randomized, double-blind study Clinical Infectious Diseases. 33: 1015-1021. PMID 11528574 DOI: 10.1086/322694  0.379
2001 Gonzalez-Ceron L, Rodriguez MH, Santillan F, Chavez B, Nettel JA, Hernandez-Avila JE, Kain KC. Plasmodium vivax: ookinete destruction and oocyst development arrest are responsible for Anopheles albimanus resistance to circumsporozoite phenotype VK247 parasites. Experimental Parasitology. 98: 152-61. PMID 11527438 DOI: 10.1006/Expr.2001.4626  0.383
2001 Forney JR, Magill AJ, Wongsrichanalai C, Sirichaisinthop J, Bautista CT, Heppner DG, Miller RS, Ockenhouse CF, Gubanov A, Shafer R, DeWitt CC, Quino-Ascurra HA, Kester KE, Kain KC, Walsh DS, et al. Malaria rapid diagnostic devices: performance characteristics of the ParaSight F device determined in a multisite field study. Journal of Clinical Microbiology. 39: 2884-90. PMID 11474008 DOI: 10.1128/Jcm.39.8.2884-2890.2001  0.368
2001 Taylor WR, Widjaja H, Richie TL, Basri H, Ohrt C, Tjitra, Taufik E, Jones TR, Kain KC, Hoffman SL. Chloroquine/doxycycline combination versus chloroquine alone, and doxycycline alone for the treatment of Plasmodium falciparum and Plasmodium vivax malaria in northeastern Irian Jaya, Indonesia. The American Journal of Tropical Medicine and Hygiene. 64: 223-8. PMID 11463107 DOI: 10.4269/Ajtmh.2001.64.223  0.373
2001 Shanks GD, Kain KC, Keystone JS. Malaria chemoprophylaxis in the age of drug resistance. II. Drugs that may be available in the future Clinical Infectious Diseases. 33: 381-385. PMID 11438908 DOI: 10.1086/321866  0.345
2001 Laoboonchai A, Kawamoto F, Thanoosingha N, Kojima S, Scott Miller RR, Kain KC, Wongsrichanalai C. PCR-based ELISA technique for malaria diagnosis of specimens from Thailand. Tropical Medicine & International Health : Tm & Ih. 6: 458-62. PMID 11422960 DOI: 10.1046/J.1365-3156.2001.00736.X  0.341
2001 Kain KC, Shanks GD, Keystone JS. Malaria chemoprophylaxis in the age of drug resistance. I. Currently recommended drug regimens Clinical Infectious Diseases. 33: 226-234. PMID 11418883 DOI: 10.1086/321817  0.32
2001 Serghides L, Kain KC. Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages. Journal of Immunology (Baltimore, Md. : 1950). 166: 6742-8. PMID 11359831 DOI: 10.4049/Jimmunol.166.11.6742  0.664
2001 Taylor WR, Doan HN, Nguyen DT, Tran TU, Fryauff DJ, Gómez-Saladín E, Kain KC, Le DC, Baird JK. Assessing drug sensitivity of Plasmodium vivax to halofantrine or choroquine in southern, central Vietnam using an extended 28-day in vivo test and polymerase chain reaction genotyping. The American Journal of Tropical Medicine and Hygiene. 62: 693-7. PMID 11304056 DOI: 10.4269/Ajtmh.2000.62.693  0.33
2001 Zhong KJ, Salas CJ, Shafer R, Gubanov A, Gasser RA, Magill AJ, Forney JR, Kain KC. Comparison of IsoCode STIX and FTA Gene Guard collection matrices as whole-blood storage and processing devices for diagnosis of malaria by PCR. Journal of Clinical Microbiology. 39: 1195-6. PMID 11230458 DOI: 10.1128/Jcm.39.3.1195-1196.2001  0.329
2001 Pillai DR, Labbé AC, Vanisaveth V, Hongvangthong B, Pomphida S, Inkathone S, Zhong K, Kain KC. Plasmodium falciparum malaria in Laos: chloroquine treatment outcome and predictive value of molecular markers. The Journal of Infectious Diseases. 183: 789-95. PMID 11181156 DOI: 10.1086/318836  0.595
2000 Pillai DR, Kain KC. Recent developments in amoebiasis:the Gal/GalNAc lectins of Entamoeba histolytica and Entamoeba dispar. Microbes and Infection / Institut Pasteur. 2: 1775-83. PMID 11137050 DOI: 10.1016/S1286-4579(00)01330-7  0.561
2000 Høgh B, Clarke PD, Camus D, Nothdurft HD, Overbosch D, Günther M, Joubert I, Kain KC, Shaw D, Roskell NS, Chulay JD. Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in non-immune travellers: A randomised, double-blind study Lancet. 356: 1888-1894. PMID 11130385 DOI: 10.1016/S0140-6736(00)03260-8  0.407
2000 Pillai DR, Kobayashi S, Kain KC. Entamoeba dispar galactose/N-acetyl-D-galactosamine lectin: evidence for differential gene expression and conformational regulation. Archives of Medical Research. 31: S234-6. PMID 11070297 DOI: 10.1016/S0188-4409(00)00224-1  0.517
2000 McGilvray ID, Serghides L, Kapus A, Rotstein OD, Kain KC. Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum-parasitized erythrocytes: a role for CD36 in malarial clearance. Blood. 96: 3231-40. PMID 11050008 DOI: 10.1182/Blood.V96.9.3231.H8003231_3231_3240  0.636
2000 Crandall I, Charuk J, Kain KC. Nonylphenolethoxylates as malarial chloroquine resistance reversal agents Antimicrobial Agents and Chemotherapy. 44: 2431-2434. PMID 10952591 DOI: 10.1128/Aac.44.9.2431-2434.2000  0.337
2000 Rodriguez MH, Gonzalez-Ceron L, Hernandez JE, Nettel JA, Villarreal C, Kain KC, Wirtz RA. Different prevalences of Plasmodium vivax phenotypes VK210 and VK247 associated with the distribution of Anopheles albimanus and Anopheles pseudopunctipennis in Mexico. The American Journal of Tropical Medicine and Hygiene. 62: 122-7. PMID 10761736 DOI: 10.4269/Ajtmh.2000.62.122  0.384
1999 Ohrt C, Mirabelli-Primdahl L, Looareesuwan S, Wilairatana P, Walsh D, Kain KC. Determination of failure of treatment of Plasmodium falciparum infection by using polymerase chain reaction single-strand conformational polymorphism fingerprinting Clinical Infectious Diseases. 28: 847-852. PMID 10825049 DOI: 10.1086/515204  0.308
1999 Pillai DR, Keystone JS, Sheppard DC, MacLean JD, MacPherson DW, Kain KC. Entamoeba histolytica and Entamoeba dispar: epidemiology and comparison of diagnostic methods in a setting of nonendemicity. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 29: 1315-8. PMID 10524983 DOI: 10.1086/313433  0.572
1999 Pillai DR, Kain KC. Immunochromatographic strip-based detection of Entamoeba histolytica-E. dispar and Giardia lamblia coproantigen. Journal of Clinical Microbiology. 37: 3017-9. PMID 10449494 DOI: 10.1128/Jcm.37.9.3017-3019.1999  0.533
1999 Pillai DR, Wan PS, Yau YC, Ravdin JI, Kain KC. The cysteine-rich region of the Entamoeba histolytica adherence lectin (170-kilodalton subunit) is sufficient for high-affinity Gal/GalNAc-specific binding in vitro. Infection and Immunity. 67: 3836-41. PMID 10417146 DOI: 10.1128/Iai.67.8.3836-3841.1999  0.548
1999 Zhong KJY, Kain KC. Evaluation of a colorimetric PCR-based assay to diagnose Plasmodium falciparum malaria in travelers Journal of Clinical Microbiology. 37: 339-341. PMID 9889214 DOI: 10.1128/Jcm.37.2.339-341.1999  0.348
1999 Gonzalez-Ceron L, Rodriguez MH, Nettel JC, Villarreal C, Kain KC, Hernandez JE. Differential susceptibilities of Anopheles albimanus and Anopheles pseudopunctipennis to infections with coindigenous Plasmodium vivax variants VK210 and VK247 in southern Mexico. Infection and Immunity. 67: 410-2. PMID 9864243 DOI: 10.1128/Iai.67.1.410-412.1999  0.341
1998 Fryauff DJ, Tuti S, Mardi A, Masbar S, Patipelohi R, Leksana B, Kain KC, Bangs MJ, Richie TL, Baird JK. Chloroquine-resistant Plasmodium vivax in transmigration settlements of West Kalimantan, Indonesia. The American Journal of Tropical Medicine and Hygiene. 59: 513-8. PMID 9790420 DOI: 10.4269/Ajtmh.1998.59.513  0.36
1998 Pieroni P, Mills CD, Ohrt C, Harrington MA, Kain KC. Comparison of the ParaSight-F test and the ICT Malaria Pf test with the polymerase chain reaction for the diagnosis of Plasmodium falciparum malaria in travellers. Transactions of the Royal Society of Tropical Medicine and Hygiene. 92: 166-9. PMID 9764322 DOI: 10.1016/S0035-9203(98)90730-1  0.385
1998 Serghides L, Crandall I, Hull E, Kain KC. The Plasmodium falciparum-CD36 interaction is modified by a single amino acid substitution in CD36. Blood. 92: 1814-9. PMID 9716613 DOI: 10.1182/Blood.V92.5.1814  0.595
1998 Kain KC, Harrington MA, Tennyson S, Keystone JS. Imported malaria: Prospective analysis of problems in diagnosis and management Clinical Infectious Diseases. 27: 142-149. PMID 9675468 DOI: 10.1086/514616  0.393
1998 Kain KC, Keystone JS. Malaria in travelers. Epidemiology, disease, and prevention Infectious Disease Clinics of North America. 12: 267-284. PMID 9658245 DOI: 10.1016/S0891-5520(05)70005-2  0.401
1998 Baqi M, Gamble K, Keystone JS, Kain KC. Malaria: Probably locally acquired in Toronto, Ontario Canadian Journal of Infectious Diseases. 9: 183-184. DOI: 10.1155/1998/150650  0.36
1997 Humar A, Harrington MA, Kain KC. Evaluation of a non-isotopic polymerase chain reaction-based assay to detect and predict treatment failure of Plasmodium vivax malaria in travellers Transactions of the Royal Society of Tropical Medicine and Hygiene. 91: 406-409. PMID 9373634 DOI: 10.1016/S0035-9203(97)90258-3  0.342
1997 Ohrt C, Mirabelli-Primdahl L, Karnasuta C, Chantakulkij S, Kain KC. Distinguishing Plasmodium falciparum treatment failures from reinfections by restriction fragment length polymorphism and polymerase chain reaction genotyping American Journal of Tropical Medicine and Hygiene. 57: 430-437. PMID 9347959 DOI: 10.4269/Ajtmh.1997.57.430  0.321
1997 Pillai DR, Britten D, Ackers JP, Ravdin JI, Kain KC. A gene homologous to hgl2 of Entamoeba histolytica is present and expressed in Entamoeba dispar. Molecular and Biochemical Parasitology. 87: 101-5. PMID 9233678 DOI: 10.1016/S0166-6851(97)00047-9  0.521
1997 Smoak BL, DeFraites RF, Magill AJ, Kain KC, Wellde BT. Plasmodium vivax infections in U.S. Army troops: Failure of primaquine to prevent relapse in studies from Somalia American Journal of Tropical Medicine and Hygiene. 56: 231-234. PMID 9080885 DOI: 10.4269/Ajtmh.1997.56.231  0.318
1997 Humar A, Ohrt C, Harrington MA, Pillai D, Kain KC. ParaSight®F test compared with the polymerase chain reaction and microscopy for the diagnosis of Plasmodium falciparum malaria in travelers American Journal of Tropical Medicine and Hygiene. 56: 44-48. PMID 9063360 DOI: 10.4269/Ajtmh.1997.56.44  0.63
1997 Pillai DR, Britten D, Ackers JP, Ravdin JI, Kain KC. The sequence of a highly homologous gene to hgl2* of Entamoeba histolytica that is present and expressed in E.dispar. Archives of Medical Research. 28: 19-20. PMID 9032997  0.471
1996 Phillips EJ, Keystone JS, Kain KC. Failure of combined chloroquine and high-dose primaquine therapy for Plasmodium vivax malaria acquired in Guyana, South America Clinical Infectious Diseases. 23: 1171-1175. PMID 8922821 DOI: 10.1093/Clinids/23.5.1171  0.353
1996 Kain KC, Gadd E, Gushulak B, McCarthy A, MacPherson D. Errors in treatment recommendations for severe malaria [22] Lancet. 348: 621-622. PMID 8774603 DOI: 10.1016/S0140-6736(05)64843-X  0.301
1996 Craig AA, Kain KC. Molecular analysis of strains of Plasmodium vivax from paired primary and relapse infections Journal of Infectious Diseases. 174: 373-379. PMID 8699069 DOI: 10.1093/Infdis/174.2.373  0.318
1996 Kain KC. Chemotherapy of drug-resistant malaria Canadian Journal of Infectious Diseases. 7: 25-33. DOI: 10.1155/1996/139612  0.34
1995 Kain KC. Chemotherapy and prevention of drug-resistant malaria Wilderness and Environmental Medicine. 6: 307-324. PMID 11990096 DOI: 10.1580/1080-6032(1995)006[0307:Capodr]2.3.Co;2  0.347
1995 Gopinath R, Keystone JS, Kain KC. Concurrent falciparum malaria and salmonella bacteremia in travelers: Report of two cases Clinical Infectious Diseases. 20: 706-708. PMID 7756501 DOI: 10.1093/Clinids/20.3.706  0.374
1994 Kain KC, Gopinath R, Yau Y, Temahivong T, Wongsrichanalai C. In vivo response of falciparum malaria to chloroquine in southern Thailand. The Journal of Infectious Diseases. 170: 258-9. PMID 8014517 DOI: 10.1093/Infdis/170.1.258  0.375
1994 Gopinath R, Wongsrichanalai C, Cordón-Rosales C, Mirabelli L, Kyle D, Kain KC. Failure to detect a Plasmodium vivax-like malaria parasite in globally collected blood samples. The Journal of Infectious Diseases. 170: 1630-3. PMID 7996011 DOI: 10.1093/Infdis/170.6.1630  0.352
1994 Kain KC, Kyle DE, Wongsrichanalai C, Brown AE, Webster HK, Vanijanonta S, Looareesuwan S. Qualitative and semiquantitative polymerase chain reaction to predict Plasmodium falciparum treatment failure. The Journal of Infectious Diseases. 170: 1626-30. PMID 7996010 DOI: 10.1093/Infdis/170.6.1626  0.349
1992 Kain KC, Brown AE, Webster HK, Wirtz RA, Keystone JS, Rodriguez MH, Kinahan J, Rowland M, Lanar DE. Circumsporozoite genotyping of global isolates of Plasmodium vivax from dried blood specimens. Journal of Clinical Microbiology. 30: 1863-6. PMID 1629344 DOI: 10.1128/Jcm.30.7.1863-1866.1992  0.322
1992 Sethabutr O, Brown AE, Panyim S, Kain KC, Webster HK, Echeverria P. Detection of Plasmodium falciparum by polymerase chain reaction in a field study. The Journal of Infectious Diseases. 166: 145-8. PMID 1607686 DOI: 10.1093/Infdis/166.1.145  0.313
1992 Kain KC, Wirtz RA, Fernandez I, Franke ED, Rodriguez MH, Lanar DE. Serologic and genetic characterization of Plasmodium vivax from whole blood-impregnated filter paper discs American Journal of Tropical Medicine and Hygiene. 46: 473-479. PMID 1575295 DOI: 10.4269/Ajtmh.1992.46.473  0.304
1992 Brown AE, Kain KC, Pipithkul J, Webster HK. Demonstration by the polymerase chain reaction of mixed Plasmodium falciparum and P. vivax infections undetected by conventional microscopy. Transactions of the Royal Society of Tropical Medicine and Hygiene. 86: 609-12. PMID 1287912 DOI: 10.1016/0035-9203(92)90147-5  0.378
1991 Kain KC, Noble MA, Barteluk RL, Tubbesing RH. Arcanobacterium hemolyticum infection: confused with scarlet fever and diphtheria. The Journal of Emergency Medicine. 9: 33-5. PMID 2045646 DOI: 10.1016/0736-4679(91)90529-O  0.314
1991 Kain KC, Barteluk RL, Kelly MT, He X, de Hua G, Ge YA, Proctor EM, Byrne S, Stiver HG. Etiology of childhood diarrhea in Beijing, China. Journal of Clinical Microbiology. 29: 90-5. PMID 1993771 DOI: 10.1128/Jcm.29.1.90-95.1991  0.3
1989 Kain KC, Kelly MT. Clinical features, epidemiology, and treatment of Plesiomonas shigelloides diarrhea. Journal of Clinical Microbiology. 27: 998-1001. PMID 2745707 DOI: 10.1128/Jcm.27.5.998-1001.1989  0.342
1987 Kain KC, Noble MA, Freeman HJ, Barteluk RL. Epidemiology and clinical features associated with Blastocystis hominis infection. Diagnostic Microbiology and Infectious Disease. 8: 235-44. PMID 3449317 DOI: 10.1016/0732-8893(87)90055-1  0.324
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