| Year |
Citation |
Score |
| 2025 |
Rawat M, Padalino G, Adika E, Okombo J, Yeo T, Brancale A, Fidock DA, Hoffmann KF, Lee MCS. Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity. Plos Pathogens. 21: e1012216. PMID 39899599 DOI: 10.1371/journal.ppat.1012216 |
0.335 |
|
| 2024 |
Knaab TC, Moritz A, Pessanha de Carvalho L, Klein S, Lungerich B, Lohse K, Kruse L, Mombo-Ngoma G, Orta L, Thibaud JL, de Villiers KA, Fidock DA, Burckhardt BB, Held J, Wittlin S, et al. TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial Activity and a High Barrier to Resistance. Journal of Medicinal Chemistry. PMID 39723908 DOI: 10.1021/acs.jmedchem.4c01465 |
0.346 |
|
| 2024 |
Hagenah LM, Yeo T, Schindler KA, Jeon JH, Bloxham TS, Small-Saunders JL, Mok S, Fidock DA. Plasmodium falciparum African PfCRT Mutant Isoforms Conducive to Piperaquine Resistance are Infrequent and Impart a Major Fitness Cost. The Journal of Infectious Diseases. PMID 39661643 DOI: 10.1093/infdis/jiae617 |
0.359 |
|
| 2024 |
Xie SC, Tai CW, Morton CJ, Ma L, Huang SC, Wittlin S, Du Y, Hu Y, Dogovski C, Salimimarand M, Griffin R, England D, de la Cruz E, Deni I, Yeo T, ... ... Fidock DA, et al. A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. Plos Pathogens. 20: e1012429. PMID 39652589 DOI: 10.1371/journal.ppat.1012429 |
0.301 |
|
| 2024 |
Gomez-Gonzalez PJ, Gupta A, Drought LG, Patel A, Okombo J, van der Watt M, Walker-Gray R, Schindler KA, Burkhard AY, Yeo T, Narwal SK, Bloxham TS, Flueck C, Walker EM, Rey JA, ... ... Fidock DA, et al. Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission. Science Advances. 10: eadq1383. PMID 39642214 DOI: 10.1126/sciadv.adq1383 |
0.407 |
|
| 2024 |
Luth MR, Godinez-Macias KP, Chen D, Okombo J, Thathy V, Cheng X, Daggupati S, Davies H, Dhingra SK, Economy JM, Edgar RCS, Gomez-Lorenzo MG, Istvan ES, Jado JC, LaMonte GM, ... ... Fidock DA, et al. Systematic in vitro evolution in reveals key determinants of drug resistance. Science (New York, N.Y.). 386: eadk9893. PMID 39607932 DOI: 10.1126/science.adk9893 |
0.357 |
|
| 2024 |
Ferreira LT, Cassiano GC, Alvarez LCS, Okombo J, Calit J, Fontinha D, Gil-Iturbe E, Coyle R, Andrade CH, Sunnerhagen P, Bargieri DY, Prudêncio M, Quick M, Cravo PV, Lee MCS, ... Fidock DA, et al. A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants. Plos Pathogens. 20: e1012627. PMID 39471233 DOI: 10.1371/journal.ppat.1012627 |
0.397 |
|
| 2024 |
Brettell SB, Janha O, Begen A, Cann G, Sharma S, Olaniyan N, Yelland T, Hole AJ, Alam B, Mayville E, Gillespie R, Capper M, Fidock DA, Milligan G, Clarke DJ, et al. Targeting CLK3 with Covalent Inhibitors: A Novel Strategy for Malaria Treatment. Journal of Medicinal Chemistry. PMID 39441986 DOI: 10.1021/acs.jmedchem.4c01300 |
0.323 |
|
| 2024 |
Awalt JK, Su W, Nguyen W, Loi K, Jarman KE, Penington JS, Ramesh S, Fairhurst KJ, Yeo T, Park H, Uhlemann AC, Chandra Maity B, De N, Mukherjee P, Chakraborty A, ... ... Fidock DA, et al. Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b. European Journal of Medicinal Chemistry. 280: 116921. PMID 39388903 DOI: 10.1016/j.ejmech.2024.116921 |
0.389 |
|
| 2024 |
Kanai M, Mok S, Yeo T, Shears MJ, Ross LS, Jeon JH, Narwal S, Haile MT, Tripathi AK, Mlambo G, Kim J, Gil-Iturbe E, Okombo J, Fairhurst KJ, Bloxham T, ... ... Fidock DA, et al. Identification of the drug/metabolite transporter 1 as a marker of quinine resistance in a NF54×Cam3.II genetic cross. Biorxiv : the Preprint Server For Biology. PMID 39386571 DOI: 10.1101/2024.09.27.615529 |
0.344 |
|
| 2024 |
Okombo J, Fidock DA. Towards next-generation treatment options to combat Plasmodium falciparum malaria. Nature Reviews. Microbiology. PMID 39367132 DOI: 10.1038/s41579-024-01099-x |
0.386 |
|
| 2024 |
Bennett JM, Narwal SK, Kabeche S, Abegg D, Thathy V, Hackett F, Yeo T, Li VL, Muir R, Faucher F, Lovell S, Blackman MJ, Adibekian A, Yeh E, Fidock DA, et al. Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets. Cell Chemical Biology. PMID 39137783 DOI: 10.1016/j.chembiol.2024.07.006 |
0.407 |
|
| 2024 |
Lawong A, Gahalawat S, Ray S, Ho N, Han Y, Ward KE, Deng X, Chen Z, Kumar A, Xing C, Hosangadi V, Fairhurst KJ, Tashiro K, Liszczak G, Shackleford DM, ... ... Fidock DA, et al. Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria. Cell Chemical Biology. PMID 39084225 DOI: 10.1016/j.chembiol.2024.07.001 |
0.328 |
|
| 2024 |
Calic PPS, Ashton TD, Mansouri M, Loi K, Jarman KE, Qiu D, Lehane AM, Roy S, Rao GP, Maity B, Wittlin S, Crespo B, Gamo FJ, Deni I, Fidock DA, et al. Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3. European Journal of Medicinal Chemistry. 276: 116677. PMID 39024967 DOI: 10.1016/j.ejmech.2024.116677 |
0.408 |
|
| 2024 |
Rawat M, Padalino G, Yeo T, Brancale A, Fidock DA, Hoffmann KF, Lee MCS. Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity. Biorxiv : the Preprint Server For Biology. PMID 38712185 DOI: 10.1101/2024.04.23.590861 |
0.304 |
|
| 2024 |
Ishengoma DS, Gosling R, Martinez-Vega R, Beshir KB, Bailey JA, Chimumbwa J, Sutherland C, Conrad MD, Tadesse FG, Juliano JJ, Kamya MR, Mbacham WF, Ménard D, Rosenthal PJ, Raman J, ... ... Fidock DA, et al. Urgent action is needed to confront artemisinin partial resistance in African malaria parasites. Nature Medicine. PMID 38710833 DOI: 10.1038/d41591-024-00028-y |
0.393 |
|
| 2024 |
Rosado-Quiñones AM, Colón-Lorenzo EE, Pala ZR, Bosch J, Kudyba K, Kudyba H, Leed SE, Roncal N, Baerga-Ortiz A, Roche-Lima A, Gerena Y, Fidock DA, Roth A, Vega-Rodríguez J, Serrano AE. Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs. Antimicrobial Agents and Chemotherapy. e0164323. PMID 38639491 DOI: 10.1128/aac.01643-23 |
0.34 |
|
| 2024 |
Small-Saunders JL, Sinha A, Bloxham TS, Hagenah LM, Sun G, Preiser PR, Dedon PC, Fidock DA. tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum. Nature Microbiology. PMID 38632343 DOI: 10.1038/s41564-024-01664-3 |
0.401 |
|
| 2024 |
Nguyen W, Boulet C, Dans MG, Loi K, Jarman KE, Watson GM, Tham WH, Fairhurst KJ, Yeo T, Fidock DA, Wittlin S, Chowdury M, de Koning-Ward TF, Chen G, Yan D, et al. Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein. European Journal of Medicinal Chemistry. 270: 116354. PMID 38554474 DOI: 10.1016/j.ejmech.2024.116354 |
0.397 |
|
| 2024 |
Platon L, Leroy D, Fidock DA, Ménard D. Drug-induced stress mediates ring-stage growth arrest and reduces parasite susceptibility to artemisinin. Microbiology Spectrum. e0350023. PMID 38363132 DOI: 10.1128/spectrum.03500-23 |
0.339 |
|
| 2024 |
Xie SC, Wang Y, Morton CJ, Metcalfe RD, Dogovski C, Pasaje CFA, Dunn E, Luth MR, Kumpornsin K, Istvan ES, Park JS, Fairhurst KJ, Ketprasit N, Yeo T, Yildirim O, ... ... Fidock DA, et al. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature Communications. 15: 937. PMID 38297033 DOI: 10.1038/s41467-024-45224-z |
0.356 |
|
| 2024 |
Bennett JM, Narwal SK, Kabeche S, Abegg D, Hackett F, Yeo T, Li VL, Muir RK, Faucher FF, Lovell S, Blackman MJ, Adibekian A, Yeh E, Fidock DA, Bogyo M. Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets. Biorxiv : the Preprint Server For Biology. PMID 38260474 DOI: 10.1101/2024.01.11.575224 |
0.391 |
|
| 2024 |
Ménard D, Mihreteab S, Fidock DA. Artemisinin-Resistant HRP2-Negative Malaria in Eritrea. Reply. The New England Journal of Medicine. 389: 2497-2498. PMID 38157513 DOI: 10.1056/NEJMc2312559 |
0.324 |
|
| 2023 |
Hagenah LM, Dhingra SK, Small-Saunders JL, Qahash T, Willems A, Schindler KA, Rangel GW, Gil-Iturbe E, Kim J, Akhundova E, Yeo T, Okombo J, Mancia F, Quick M, Roepe PD, ... ... Fidock DA, et al. Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered physiology. Mbio. e0183223. PMID 38059639 DOI: 10.1128/mbio.01832-23 |
0.401 |
|
| 2023 |
Mok S, Yeo T, Hong D, Shears MJ, Ross LS, Ward KE, Dhingra SK, Kanai M, Bridgford JL, Tripathi AK, Mlambo G, Burkhard AY, Ansbro MR, Fairhurst KJ, Gil-Iturbe E, ... ... Fidock DA, et al. Mapping the genomic landscape of multidrug resistance in and its impact on parasite fitness. Science Advances. 9: eadi2364. PMID 37939186 DOI: 10.1126/sciadv.adi2364 |
0.39 |
|
| 2023 |
Mok S, Fidock DA. Determinants of piperaquine-resistant malaria in South America. The Lancet. Infectious Diseases. PMID 37858324 DOI: 10.1016/S1473-3099(23)00564-9 |
0.314 |
|
| 2023 |
Bennett JM, Ward KE, Muir RK, Kabeche S, Yoo E, Yeo T, Lam G, Zhang H, Almaliti J, Berger G, Faucher FF, Lin G, Gerwick WH, Yeh E, Fidock DA, et al. Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in . Acs Infectious Diseases. PMID 37712594 DOI: 10.1021/acsinfecdis.3c00310 |
0.35 |
|
| 2023 |
Stadler E, Maiga M, Friedrich L, Thathy V, Demarta-Gatsi C, Dara A, Sogore F, Striepen J, Oeuvray C, Djimdé AA, Lee MCS, Dembélé L, Fidock DA, Khoury DS, Spangenberg T. Author Correction: Propensity of selecting mutant parasites for the antimalarial drug cabamiquine. Nature Communications. 14: 5447. PMID 37673924 DOI: 10.1038/s41467-023-41287-6 |
0.317 |
|
| 2023 |
Stadler E, Maiga M, Friedrich L, Thathy V, Demarta-Gatsi C, Dara A, Sogore F, Striepen J, Oeuvray C, Djimdé AA, Lee MCS, Dembélé L, Fidock DA, Khoury DS, Spangenberg T. Propensity of selecting mutant parasites for the antimalarial drug cabamiquine. Nature Communications. 14: 5205. PMID 37626093 DOI: 10.1038/s41467-023-40974-8 |
0.356 |
|
| 2023 |
Tilley L, Xie S, Wang Y, Morton C, Metcalfe R, Dogovski C, Pasaje CF, Dunn E, Luth M, Kumpornsin K, Istvan E, Park J, Fairhurst K, Yeo T, Yildirim O, ... ... Fidock D, et al. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Research Square. PMID 37546892 DOI: 10.21203/rs.3.rs-3198291/v1 |
0.356 |
|
| 2023 |
Mok S, Yeo T, Hong D, Shears MJ, Ross LS, Ward KE, Dhingra SK, Kanai M, Bridgford JL, Tripathi AK, Mlambo G, Burkhard AY, Fairhurst KJ, Gil-Iturbe E, Park H, ... ... Fidock DA, et al. Mapping the genomic landscape of multidrug resistance in and its impact on parasite fitness. Biorxiv : the Preprint Server For Biology. PMID 37398288 DOI: 10.1101/2023.06.02.543338 |
0.389 |
|
| 2023 |
Kümpornsin K, Kochakarn T, Yeo T, Okombo J, Luth MR, Hoshizaki J, Rawat M, Pearson RD, Schindler KA, Mok S, Park H, Uhlemann AC, Jana GP, Maity BC, Laleu B, ... ... Fidock DA, et al. Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum. Nature Communications. 14: 3059. PMID 37244916 DOI: 10.1038/s41467-023-38774-1 |
0.377 |
|
| 2023 |
Armstrong JF, Campo B, Alexander SPH, Arendse LB, Cheng X, Davenport AP, Faccenda E, Fidock DA, Godinez-Macias KP, Harding SD, Kato N, Lee MCS, Luth MR, Mazitschek R, Mittal N, et al. Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR Review X. British Journal of Pharmacology. PMID 37197802 DOI: 10.1111/bph.16144 |
0.392 |
|
| 2023 |
Deni I, Stokes BH, Ward KE, Fairhurst KJ, Pasaje CFA, Yeo T, Akbar S, Park H, Muir R, Bick DS, Zhan W, Zhang H, Liu YJ, Ng CL, Kirkman LA, ... ... Fidock DA, et al. Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell Chemical Biology. PMID 36963402 DOI: 10.1016/j.chembiol.2023.03.002 |
0.396 |
|
| 2023 |
Bopp S, Pasaje CFA, Summers RL, Magistrado-Coxen P, Schindler KA, Corpas-Lopez V, Yeo T, Mok S, Dey S, Smick S, Nasamu AS, Demas AR, Milne R, Wiedemar N, Corey V, ... ... Fidock DA, et al. Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature Communications. 14: 1455. PMID 36927839 DOI: 10.1038/s41467-023-36921-2 |
0.436 |
|
| 2023 |
Istvan ES, Guerra F, Abraham M, Huang KS, Rocamora F, Zhao H, Xu L, Pasaje C, Kumpornsin K, Luth MR, Cui H, Yang T, Palomo Diaz S, Gomez-Lorenzo MG, Qahash T, ... ... Fidock DA, et al. Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science Translational Medicine. 15: eadc9249. PMID 36888694 DOI: 10.1126/scitranslmed.adc9249 |
0.417 |
|
| 2023 |
Ashton TD, Dans MG, Favuzza P, Ngo A, Lehane AM, Zhang X, Qiu D, Chandra Maity B, De N, Schindler KA, Yeo T, Park H, Uhlemann AC, Churchyard A, Baum J, ... Fidock DA, et al. Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4. Journal of Medicinal Chemistry. PMID 36812492 DOI: 10.1021/acs.jmedchem.2c02092 |
0.424 |
|
| 2022 |
Okombo J, Mok S, Qahash T, Yeo T, Bath J, Orchard LM, Owens E, Koo I, Albert I, Llinás M, Fidock DA. Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages. Plos Pathogens. 18: e1010926. PMID 36306287 DOI: 10.1371/journal.ppat.1010926 |
0.416 |
|
| 2022 |
Arendse LB, Murithi JM, Qahash T, Pasaje CFA, Godoy LC, Dey S, Gibhard L, Ghidelli-Disse S, Drewes G, Bantscheff M, Lafuente-Monasterio MJ, Fienberg S, Wambua L, Gachuhi S, Coertzen D, ... ... Fidock DA, et al. The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple kinases and life cycle stages. Science Translational Medicine. 14: eabo7219. PMID 36260689 DOI: 10.1126/scitranslmed.abo7219 |
0.352 |
|
| 2022 |
Qiu D, Pei JV, Rosling JEO, Thathy V, Li D, Xue Y, Tanner JD, Penington JS, Aw YTV, Aw JYH, Xu G, Tripathi AK, Gnadig NF, Yeo T, Fairhurst KJ, ... ... Fidock DA, et al. A G358S mutation in the Plasmodium falciparum Na pump PfATP4 confers clinically-relevant resistance to cipargamin. Nature Communications. 13: 5746. PMID 36180431 DOI: 10.1038/s41467-022-33403-9 |
0.313 |
|
| 2022 |
Laleu B, Rubiano K, Yeo T, Hallyburton I, Anderson M, Crespo-Fernandez B, Gamo FJ, Antonova-Koch Y, Orjuela-Sanchez P, Wittlin S, Jana GP, Maity BC, Chenu E, Duffy J, Sjö P, ... ... Fidock DA, et al. Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and the Identification of its Mode of Resistance as PfeEF2. Chemmedchem. PMID 36129427 DOI: 10.1002/cmdc.202200393 |
0.421 |
|
| 2022 |
Wicht KJ, Small-Saunders JL, Hagenah LM, Mok S, Fidock DA. Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials. The Journal of Infectious Diseases. PMID 36082431 DOI: 10.1093/infdis/jiac365 |
0.414 |
|
| 2022 |
Ward KE, Fidock DA, Bridgford JL. Plasmodium falciparum resistance to artemisinin-based combination therapies. Current Opinion in Microbiology. 69: 102193. PMID 36007459 DOI: 10.1016/j.mib.2022.102193 |
0.377 |
|
| 2022 |
de Vries LE, Jansen PAM, Barcelo C, Munro J, Verhoef JMJ, Pasaje CFA, Rubiano K, Striepen J, Abla N, Berning L, Bolscher JM, Demarta-Gatsi C, Henderson RWM, Huijs T, Koolen KMJ, ... ... Fidock DA, et al. Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. Nature Communications. 13: 2158. PMID 35444200 DOI: 10.1038/s41467-022-29688-5 |
0.385 |
|
| 2022 |
Stokes BH, Ward KE, Fidock DA. Evidence of Artemisinin-Resistant Malaria in Africa. The New England Journal of Medicine. 386: 1385-1386. PMID 35388682 DOI: 10.1056/NEJMc2117480 |
0.337 |
|
| 2022 |
Barber BE, Fernandez M, Patel HB, Barcelo C, Woolley SD, Patel H, Llewellyn S, Abd-Rahman AN, Sharma S, Jain M, Ghoghari A, Di Resta I, Fuchs A, Deni I, Yeo T, ... ... Fidock DA, et al. Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study. The Lancet. Infectious Diseases. PMID 35247321 DOI: 10.1016/S1473-3099(21)00679-4 |
0.318 |
|
| 2022 |
Small-Saunders JL, Hagenah LM, Wicht KJ, Dhingra SK, Deni I, Kim J, Vendome J, Gil-Iturbe E, Roepe PD, Mehta M, Mancia F, Quick M, Eppstein MJ, Fidock DA. Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance. Plos Pathogens. 18: e1010278. PMID 35130315 DOI: 10.1371/journal.ppat.1010278 |
0.386 |
|
| 2021 |
Summers RL, Pasaje CFA, Pisco JP, Striepen J, Luth MR, Kumpornsin K, Carpenter EF, Munro JT, Lin, Plater A, Punekar AS, Shepherd AM, Shepherd SM, Vanaerschot M, Murithi JM, ... ... Fidock DA, et al. Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. Cell Chemical Biology. PMID 34348113 DOI: 10.1016/j.chembiol.2021.07.010 |
0.373 |
|
| 2021 |
Murithi JM, Pascal C, Bath J, Boulenc X, Gnädig NF, Pasaje CFA, Rubiano K, Yeo T, Mok S, Klieber S, Desert P, Jiménez-Díaz MB, Marfurt J, Rouillier M, Cherkaoui-Rbati MH, ... ... Fidock DA, et al. The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to parasite resistance. Science Translational Medicine. 13. PMID 34290058 DOI: 10.1126/scitranslmed.abg6013 |
0.352 |
|
| 2021 |
Murithi JM, Deni I, Pasaje CFA, Okombo J, Bridgford JL, Gnädig NF, Edwards RL, Yeo T, Mok S, Burkhard AY, Coburn-Flynn O, Istvan ES, Sakata-Kato T, Gomez-Lorenzo MG, Cowell AN, ... ... Fidock DA, et al. The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance. Cell Chemical Biology. PMID 34233174 DOI: 10.1016/j.chembiol.2021.06.006 |
0.411 |
|
| 2021 |
Uwimana A, Legrand E, Stokes BH, Ndikumana JM, Warsame M, Umulisa N, Ngamije D, Munyaneza T, Mazarati JB, Munguti K, Campagne P, Criscuolo A, Ariey F, Murindahabi M, Ringwald P, ... Fidock DA, et al. Author Correction: Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda. Nature Medicine. PMID 34045739 DOI: 10.1038/s41591-021-01365-y |
0.371 |
|
| 2021 |
Duffey M, Blasco B, Burrows JN, Wells TNC, Fidock DA, Leroy D. Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials. Trends in Parasitology. PMID 34001441 DOI: 10.1016/j.pt.2021.04.006 |
0.357 |
|
| 2021 |
Okaniwa M, Shibata A, Ochida A, Akao Y, White KL, Shackleford DM, Duffy S, Lucantoni L, Dey S, Striepen J, Yeo T, Mok S, Aguiar ACC, Sturm A, Crespo B, ... ... Fidock DA, et al. Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Cytoplasmic Prolyl-tRNA Synthetase Inhibitors. Acs Infectious Diseases. PMID 33929818 DOI: 10.1021/acsinfecdis.1c00020 |
0.353 |
|
| 2021 |
Okombo J, Kanai M, Deni I, Fidock DA. Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology. Trends in Parasitology. PMID 33715941 DOI: 10.1016/j.pt.2021.02.007 |
0.337 |
|
| 2021 |
Biddau M, Santha Kumar TR, Henrich P, Laine LM, Blackburn GJ, Chokkathukalam A, Li T, Lee Sim K, King L, Hoffman SL, Barrett MP, Coombs GH, McFadden GI, Fidock DA, Müller S, et al. Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes. International Journal For Parasitology. PMID 33713652 DOI: 10.1016/j.ijpara.2020.10.011 |
0.427 |
|
| 2021 |
Lawong A, Gahalawat S, Okombo J, Striepen J, Yeo T, Mok S, Deni I, Bridgford JL, Niederstrasser H, Zhou A, Posner B, Wittlin S, Gamo FJ, Crespo B, Churchyard A, ... ... Fidock DA, et al. Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in . Journal of Medicinal Chemistry. PMID 33620219 DOI: 10.1021/acs.jmedchem.0c02022 |
0.415 |
|
| 2021 |
Le Manach C, Dam J, Woodland JG, Kaur G, Khonde LP, Brunschwig C, Njoroge M, Wicht KJ, Horatscheck A, Paquet T, Boyle GA, Gibhard L, Taylor D, Lawrence N, Yeo T, ... ... Fidock DA, et al. Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite and Optimization Efforts. Journal of Medicinal Chemistry. PMID 33573376 DOI: 10.1021/acs.jmedchem.1c00034 |
0.369 |
|
| 2021 |
Dorjsuren D, Eastman RT, Wicht KJ, Jansen D, Talley DC, Sigmon BA, Zakharov AV, Roncal N, Girvin AT, Antonova-Koch Y, Will PM, Shah P, Sun H, Klumpp-Thomas C, Mok S, ... ... Fidock DA, et al. Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites. Scientific Reports. 11: 2121. PMID 33483532 DOI: 10.1038/s41598-021-81486-z |
0.401 |
|
| 2021 |
Miguel-Blanco C, Murithi JM, Benavente ED, Angrisano F, Sala KA, van Schalkwyk DA, Vanaerschot M, Schwach F, Fuchter MJ, Billker O, Sutherland CJ, Campino SG, Clark TG, Blagborough AM, Fidock DA, et al. The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957. Scientific Reports. 11: 1888. PMID 33479319 DOI: 10.1038/s41598-021-81343-z |
0.449 |
|
| 2020 |
Calçada C, Silva M, Baptista V, Thathy V, Silva-Pedrosa R, Granja D, Ferreira PE, Gil JP, Fidock DA, Veiga MI. Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport. Mbio. 11. PMID 33262257 DOI: 10.1128/mBio.02093-20 |
0.413 |
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| 2020 |
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Eastman RT, Dharia NV, Winzeler EA, Fidock DA. Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrobial Agents and Chemotherapy. 55: 3908-16. PMID 21576453 DOI: 10.1128/Aac.01793-10 |
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Pereira MR, Henrich PP, Sidhu AB, Johnson D, Hardink J, Van Deusen J, Lin J, Gore K, O'Brien C, Wele M, Djimde A, Chandra R, Fidock DA. In vivo and in vitro antimalarial properties of azithromycin-chloroquine combinations that include the resistance reversal agent amlodipine. Antimicrobial Agents and Chemotherapy. 55: 3115-24. PMID 21464242 DOI: 10.1128/Aac.01566-10 |
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| 2011 |
Lehane AM, van Schalkwyk DA, Valderramos SG, Fidock DA, Kirk K. Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT. Antimicrobial Agents and Chemotherapy. 55: 2310-8. PMID 21343459 DOI: 10.1128/Aac.01167-10 |
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| 2011 |
Ecker A, Lakshmanan V, Sinnis P, Coppens I, Fidock DA. Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes. The Journal of Infectious Diseases. 203: 228-36. PMID 21288823 DOI: 10.1093/Infdis/Jiq036 |
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| 2011 |
Baschong W, Wittlin S, Inglis KA, Fairlamb AH, Croft SL, Kumar TR, Fidock DA, Brun R. Triclosan is minimally effective in rodent malaria models. Nature Medicine. 17: 33-4; author reply 3. PMID 21217674 DOI: 10.1038/Nm0111-33 |
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Anderson T, Nkhoma S, Ecker A, Fidock D. How can we identify parasite genes that underlie antimalarial drug resistance? Pharmacogenomics. 12: 59-85. PMID 21174623 DOI: 10.2217/Pgs.10.165 |
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| 2010 |
Jayabalasingham B, Menard R, Fidock DA. Recent insights into fatty acid acquisition and metabolism in malarial parasites. F1000 Biology Reports. 2. PMID 20948809 DOI: 10.3410/B2-24 |
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Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, ... ... Fidock DA, et al. Spiroindolones, a potent compound class for the treatment of malaria. Science (New York, N.Y.). 329: 1175-80. PMID 20813948 DOI: 10.1126/Science.1193225 |
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Adjalley SH, Lee MC, Fidock DA. A method for rapid genetic integration into Plasmodium falciparum utilizing mycobacteriophage Bxb1 integrase. Methods in Molecular Biology (Clifton, N.J.). 634: 87-100. PMID 20676977 DOI: 10.1007/978-1-60761-652-8_6 |
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Valderramos SG, Scanfeld D, Uhlemann AC, Fidock DA, Krishna S. Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance. Antimicrobial Agents and Chemotherapy. 54: 3842-52. PMID 20566762 DOI: 10.1128/Aac.00121-10 |
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Valderramos SG, Valderramos JC, Musset L, Purcell LA, Mercereau-Puijalon O, Legrand E, Fidock DA. Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum. Plos Pathogens. 6: e1000887. PMID 20485514 DOI: 10.1371/Journal.Ppat.1000887 |
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Fidock DA. Drug discovery: Priming the antimalarial pipeline. Nature. 465: 297-8. PMID 20485420 DOI: 10.1038/465297A |
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Melcher M, Muhle RA, Henrich PP, Kraemer SM, Avril M, Vigan-Womas I, Mercereau-Puijalon O, Smith JD, Fidock DA. Identification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells. Cellular Microbiology. 12: 1446-62. PMID 20438573 DOI: 10.1111/J.1462-5822.2010.01481.X |
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Eastman RT, Fidock DA. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nature Reviews. Microbiology. 7: 864-74. PMID 19881520 DOI: 10.1038/Nrmicro2239 |
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Moura PA, Dame JB, Fidock DA. Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors. Antimicrobial Agents and Chemotherapy. 53: 4968-78. PMID 19752273 DOI: 10.1128/Aac.00882-09 |
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Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature Chemical Biology. 5: 765-71. PMID 19734910 DOI: 10.1038/Nchembio.215 |
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Gratraud P, Huws E, Falkard B, Adjalley S, Fidock DA, Berry L, Jacobs WR, Baird MS, Vial H, Kremer L. Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target. Plos One. 4: e6889. PMID 19707292 DOI: 10.1371/Journal.Pone.0006889 |
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Ayong L, Raghavan A, Schneider TG, Taraschi TF, Fidock DA, Chakrabarti D. The longin domain regulates the steady-state dynamics of Sec22 in Plasmodium falciparum. Eukaryotic Cell. 8: 1330-40. PMID 19617396 DOI: 10.1128/Ec.00092-09 |
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Muhle RA, Adjalley S, Falkard B, Nkrumah LJ, Muhle ME, Fidock DA. A var gene promoter implicated in severe malaria nucleates silencing and is regulated by 3' untranslated region and intronic cis-elements. International Journal For Parasitology. 39: 1425-39. PMID 19463825 DOI: 10.1016/J.Ijpara.2009.05.001 |
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Nkrumah LJ, Riegelhaupt PM, Moura P, Johnson DJ, Patel J, Hayton K, Ferdig MT, Wellems TE, Akabas MH, Fidock DA. Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Molecular and Biochemical Parasitology. 165: 122-31. PMID 19428659 DOI: 10.1016/J.Molbiopara.2009.01.011 |
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Dharia NV, Sidhu AB, Cassera MB, Westenberger SJ, Bopp SE, Eastman RT, Plouffe D, Batalov S, Park DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler EA. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biology. 10: R21. PMID 19216790 DOI: 10.1186/Gb-2009-10-2-R21 |
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Sisowath C, Petersen I, Veiga MI, Mårtensson A, Premji Z, Björkman A, Fidock DA, Gil JP. In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa. The Journal of Infectious Diseases. 199: 750-7. PMID 19210165 DOI: 10.1086/596738 |
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Chiang AN, Valderramos JC, Balachandran R, Chovatiya RJ, Mead BP, Schneider C, Bell SL, Klein MG, Huryn DM, Chen XS, Day BW, Fidock DA, Wipf P, Brodsky JL. Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. Bioorganic & Medicinal Chemistry. 17: 1527-33. PMID 19195901 DOI: 10.1016/J.Bmc.2009.01.024 |
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Yu M, Kumar TR, Nkrumah LJ, Coppi A, Retzlaff S, Li CD, Kelly BJ, Moura PA, Lakshmanan V, Freundlich JS, Valderramos JC, Vilcheze C, Siedner M, Tsai JH, Falkard B, ... ... Fidock DA, et al. The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host & Microbe. 4: 567-78. PMID 19064257 DOI: 10.1016/J.Chom.2008.11.001 |
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Fidock DA, Eastman RT, Ward SA, Meshnick SR. Recent highlights in antimalarial drug resistance and chemotherapy research. Trends in Parasitology. 24: 537-44. PMID 18938106 DOI: 10.1016/J.Pt.2008.09.005 |
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Lee MC, Moura PA, Miller EA, Fidock DA. Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif. Molecular Microbiology. 68: 1535-46. PMID 18410493 DOI: 10.1111/J.1365-2958.2008.06250.X |
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Ekland EH, Fidock DA. In vitro evaluations of antimalarial drugs and their relevance to clinical outcomes. International Journal For Parasitology. 38: 743-7. PMID 18406409 DOI: 10.1016/J.Ijpara.2008.03.004 |
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Greenwood BM, Fidock DA, Kyle DE, Kappe SH, Alonso PL, Collins FH, Duffy PE. Malaria: progress, perils, and prospects for eradication. The Journal of Clinical Investigation. 118: 1266-76. PMID 18382739 DOI: 10.1172/Jci33996 |
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Lee MC, Fidock DA. Arresting malaria parasite egress from infected red blood cells. Nature Chemical Biology. 4: 161-2. PMID 18277974 DOI: 10.1038/Nchembio0308-161 |
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Pendyala PR, Ayong L, Eatrides J, Schreiber M, Pham C, Chakrabarti R, Fidock DA, Allen CM, Chakrabarti D. Characterization of a PRL protein tyrosine phosphatase from Plasmodium falciparum. Molecular and Biochemical Parasitology. 158: 1-10. PMID 18096253 DOI: 10.1016/J.Molbiopara.2007.11.006 |
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Ekland EH, Fidock DA. Advances in understanding the genetic basis of antimalarial drug resistance. Current Opinion in Microbiology. 10: 363-70. PMID 17709280 DOI: 10.1016/J.Mib.2007.07.007 |
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Hunt P, Afonso A, Creasey A, Culleton R, Sidhu AB, Logan J, Valderramos SG, McNae I, Cheesman S, do Rosario V, Carter R, Fidock DA, Cravo P. Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites. Molecular Microbiology. 65: 27-40. PMID 17581118 DOI: 10.1111/J.1365-2958.2007.05753.X |
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Freundlich JS, Wang F, Tsai HC, Kuo M, Shieh HM, Anderson JW, Nkrumah LJ, Valderramos JC, Yu M, Kumar TR, Valderramos SG, Jacobs WR, Schiehser GA, Jacobus DP, Fidock DA, et al. X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy. The Journal of Biological Chemistry. 282: 25436-44. PMID 17567585 DOI: 10.1074/Jbc.M701813200 |
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Nicola G, Smith CA, Lucumi E, Kuo MR, Karagyozov L, Fidock DA, Sacchettini JC, Abagyan R. Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening. Biochemical and Biophysical Research Communications. 358: 686-91. PMID 17509532 DOI: 10.1016/J.Bbrc.2007.04.113 |
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Sanchez CP, Rohrbach P, McLean JE, Fidock DA, Stein WD, Lanzer M. Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum. Molecular Microbiology. 64: 407-20. PMID 17493125 DOI: 10.1111/J.1365-2958.2007.05664.X |
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Bonilla JA, Moura PA, Bonilla TD, Yowell CA, Fidock DA, Dame JB. Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum. International Journal For Parasitology. 37: 317-27. PMID 17207486 DOI: 10.1016/J.Ijpara.2006.11.008 |
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Sidhu AB, Sun Q, Nkrumah LJ, Dunne MW, Sacchettini JC, Fidock DA. In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin. The Journal of Biological Chemistry. 282: 2494-504. PMID 17110371 DOI: 10.1074/Jbc.M608615200 |
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Reeves DC, Liebelt DA, Lakshmanan V, Roepe PD, Fidock DA, Akabas MH. Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms. Molecular and Biochemical Parasitology. 150: 288-99. PMID 17014918 DOI: 10.1016/J.Molbiopara.2006.09.001 |
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Valderramos SG, Fidock DA. Transporters involved in resistance to antimalarial drugs. Trends in Pharmacological Sciences. 27: 594-601. PMID 16996622 DOI: 10.1016/J.Tips.2006.09.005 |
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Bray PG, Mungthin M, Hastings IM, Biagini GA, Saidu DK, Lakshmanan V, Johnson DJ, Hughes RH, Stocks PA, O'Neill PM, Fidock DA, Warhurst DC, Ward SA. PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX. Molecular Microbiology. 62: 238-51. PMID 16956382 DOI: 10.1111/J.1365-2958.2006.05368.X |
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Nkrumah LJ, Muhle RA, Moura PA, Ghosh P, Hatfull GF, Jacobs WR, Fidock DA. Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase. Nature Methods. 3: 615-21. PMID 16862136 DOI: 10.1038/Nmeth904 |
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Sidhu AB, Uhlemann AC, Valderramos SG, Valderramos JC, Krishna S, Fidock DA. Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. The Journal of Infectious Diseases. 194: 528-35. PMID 16845638 DOI: 10.1086/507115 |
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Rohrbach P, Sanchez CP, Hayton K, Friedrich O, Patel J, Sidhu AB, Ferdig MT, Fidock DA, Lanzer M. Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum. The Embo Journal. 25: 3000-11. PMID 16794577 DOI: 10.1038/Sj.Emboj.7601203 |
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LaCrue AN, Sivaguru M, Walter MF, Fidock DA, James AA, Beerntsen BT. A ubiquitous Plasmodium protein displays a unique surface labeling pattern in sporozoites. Molecular and Biochemical Parasitology. 148: 199-209. PMID 16697061 DOI: 10.1016/J.Molbiopara.2006.03.016 |
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Freundlich JS, Yu M, Lucumi E, Kuo M, Tsai HC, Valderramos JC, Karagyozov L, Jacobs WR, Schiehser GA, Fidock DA, Jacobus DP, Sacchettini JC. Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives. Bioorganic & Medicinal Chemistry Letters. 16: 2163-9. PMID 16466916 DOI: 10.1016/J.Bmcl.2006.01.051 |
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Randrianarivelojosia M, Fidock DA, Belmonte O, Valderramos SG, Mercereau-Puijalon O, Ariey F. First evidence of pfcrt mutant Plasmodium falciparum in Madagascar. Transactions of the Royal Society of Tropical Medicine and Hygiene. 100: 826-30. PMID 16442577 DOI: 10.1016/J.Trstmh.2005.10.009 |
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Furuya T, Mu J, Hayton K, Liu A, Duan J, Nkrumah L, Joy DA, Fidock DA, Fujioka H, Vaidya AB, Wellems TE, Su XZ. Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 16813-8. PMID 16275909 DOI: 10.1073/Pnas.0501858102 |
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Biagini GA, Fidock DA, Bray PG, Ward SA. Mutations conferring drug resistance in malaria parasite drug transporters Pgh1 and PfCRT do not affect steady-state vacuolar Ca2+. Antimicrobial Agents and Chemotherapy. 49: 4807-8. PMID 16251339 DOI: 10.1128/Aac.49.11.4807-4808.2005 |
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Freundlich JS, Anderson JW, Sarantakis D, Shieh HM, Yu M, Valderramos JC, Lucumi E, Kuo M, Jacobs WR, Fidock DA, Schiehser GA, Jacobus DP, Sacchettini JC. Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives. Bioorganic & Medicinal Chemistry Letters. 15: 5247-52. PMID 16198563 DOI: 10.1016/J.Bmcl.2005.08.044 |
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Sidhu AB, Valderramos SG, Fidock DA. pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Molecular Microbiology. 57: 913-26. PMID 16091034 DOI: 10.1111/J.1365-2958.2005.04729.X |
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Sanchez CP, McLean JE, Rohrbach P, Fidock DA, Stein WD, Lanzer M. Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum. Biochemistry. 44: 9862-70. PMID 16026158 DOI: 10.1021/Bi050061F |
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Lakshmanan V, Bray PG, Verdier-Pinard D, Johnson DJ, Horrocks P, Muhle RA, Alakpa GE, Hughes RH, Ward SA, Krogstad DJ, Sidhu AB, Fidock DA. A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance. The Embo Journal. 24: 2294-305. PMID 15944738 DOI: 10.1038/Sj.Emboj.7600681 |
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Bray PG, Martin RE, Tilley L, Ward SA, Kirk K, Fidock DA. Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance. Molecular Microbiology. 56: 323-33. PMID 15813727 DOI: 10.1111/J.1365-2958.2005.04556.X |
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Omara-Opyene AL, Moura PA, Sulsona CR, Bonilla JA, Yowell CA, Fujioka H, Fidock DA, Dame JB. Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy. The Journal of Biological Chemistry. 279: 54088-96. PMID 15491999 DOI: 10.1074/Jbc.M409605200 |
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Johnson DJ, Fidock DA, Mungthin M, Lakshmanan V, Sidhu AB, Bray PG, Ward SA. Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents. Molecular Cell. 15: 867-77. PMID 15383277 DOI: 10.1016/J.Molcel.2004.09.012 |
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Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S. Antimalarial drug discovery: efficacy models for compound screening. Nature Reviews. Drug Discovery. 3: 509-20. PMID 15173840 DOI: 10.1038/Nrd1416 |
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Bennett TN, Kosar AD, Ursos LM, Dzekunov S, Singh Sidhu AB, Fidock DA, Roepe PD. Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH. Molecular and Biochemical Parasitology. 133: 99-114. PMID 14668017 DOI: 10.1016/J.Molbiopara.2003.09.008 |
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Waller KL, Muhle RA, Ursos LM, Horrocks P, Verdier-Pinard D, Sidhu AB, Fujioka H, Roepe PD, Fidock DA. Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter. The Journal of Biological Chemistry. 278: 33593-601. PMID 12813054 DOI: 10.1074/Jbc.M302215200 |
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Kuo MR, Morbidoni HR, Alland D, Sneddon SF, Gourlie BB, Staveski MM, Leonard M, Gregory JS, Janjigian AD, Yee C, Musser JM, Kreiswirth B, Iwamoto H, Perozzo R, Jacobs WR, ... ... Fidock DA, et al. Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. The Journal of Biological Chemistry. 278: 20851-9. PMID 12606558 DOI: 10.1074/Jbc.M211968200 |
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Singh Sidhu AB, Verdier-Pinard D, Fidock DA. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations Science. 298: 210-213. PMID 12364805 DOI: 10.1126/Science.1074045 |
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Fidock DA, Nguyen TV, Beerntsen BT, James AA. Production of stage-specific Plasmodium falciparum cDNA libraries using subtractive hybridization. Methods in Molecular Medicine. 72: 277-89. PMID 12125125 DOI: 10.1385/1-59259-271-6:277 |
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Fidock DA, Rathore D, McCutchan TF. Construction of Plasmodium falciparum lambda cDNA libraries Methods in Molecular Medicine. 72: 265-275. PMID 12125124 DOI: 10.1385/1-59259-271-6:265 |
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Perozzo R, Kuo M, Sidhu ABS, Valiyaveettil JT, Bittman R, Jacobs WR, Fidock DA, Sacchettini JC. Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase Journal of Biological Chemistry. 277: 13106-13114. PMID 11792710 DOI: 10.1074/Jbc.M112000200 |
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Cooper RA, Ferdig MT, Su XZ, Ursos LM, Mu J, Nomura T, Fujioka H, Fidock DA, Roepe PD, Wellems TE. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Molecular Pharmacology. 61: 35-42. PMID 11752204 DOI: 10.1124/Mol.61.1.35 |
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Mehlotra RK, Fujioka H, Roepe PD, Janneh O, Ursos LM, Jacobs-Lorena V, McNamara DT, Bockarie MJ, Kazura JW, Kyle DE, Fidock DA, Zimmerman PA. Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America. Proceedings of the National Academy of Sciences of the United States of America. 98: 12689-94. PMID 11675500 DOI: 10.1073/Pnas.221440898 |
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Carlton JM, Fidock DA, Djimdé A, Plowe CV, Wellems TE. Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum. Current Opinion in Microbiology. 4: 415-20. PMID 11495804 DOI: 10.1016/S1369-5274(00)00228-9 |
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Nguyen TV, Fujioka H, Kang AS, Rogers WO, Fidock DA, James AA. Stage-dependent Localization of a Novel Gene Product of the Malaria Parasite, Plasmodium falciparum Journal of Biological Chemistry. 276: 26724-26731. PMID 11371568 DOI: 10.1074/Jbc.M103375200 |
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Tsai YL, Hayward RE, Langer RC, Fidock DA, Vinetz JM. Disruption of Plasmodium falciparum chitinase markedly impairs parasite invasion of mosquito midgut Infection and Immunity. 69: 4048-4054. PMID 11349075 DOI: 10.1128/Iai.69.6.4048-4054.2001 |
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Nomura T, Carlton JMR, Baird JK, Del Portillo HA, Fryauff DJ, Rathore D, Fidock DA, Su XZ, Collins WE, McCutchan TF, Wootton JC, Wellems TE. Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria Journal of Infectious Diseases. 183: 1653-1661. PMID 11343215 DOI: 10.1086/320707 |
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Djimdé A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourté Y, Coulibaly D, Dicko A, Su XZ, Nomura T, Fidock DA, Wellems TE, Plowe CV. A molecular marker for chloroquine-resistant falciparum malaria. The New England Journal of Medicine. 344: 257-63. PMID 11172152 DOI: 10.1056/Nejm200101253440403 |
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Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu AB, Naudé B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Molecular Cell. 6: 861-71. PMID 11090624 DOI: 10.1016/S1097-2765(05)00077-8 |
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Kaneko O, Fidock DA, Schwartz OM, Miller LH. Disruption of the C-terminal region of EBA-175 in the Dd2/Nm clone of Plasmodium falciparum does not affect erythrocyte invasion. Molecular and Biochemical Parasitology. 110: 135-46. PMID 10989151 DOI: 10.1016/S0166-6851(00)00263-2 |
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Fidock DA, Nomura T, Cooper RA, Su XZ, Talley AK, Wellems TE. Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum Molecular and Biochemical Parasitology. 110: 1-10. PMID 10989140 DOI: 10.1016/S0166-6851(00)00249-8 |
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Fidock DA, Nguyen TV, Ribeiro JM, Valenzuela JG, James AA. Plasmodium falciparum: Generation of a cDNA library enriched in sporozoite-specific transcripts by directional tag subtractive hybridization Experimental Parasitology. 95: 220-225. PMID 10964651 DOI: 10.1006/Expr.2000.4528 |
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Templeton TJ, Kaslow DC, Fidock DA. Developmental arrest of the human malaria parasite Plasmodium falciparum within the mosquito midgut via CTRP gene disruption. Molecular Microbiology. 36: 1-9. PMID 10760158 DOI: 10.1046/J.1365-2958.2000.01821.X |
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de Koning-Ward TF, Fidock DA, Thathy V, Menard R, van Spaendonk RM, Waters AP, Janse CJ. The selectable marker human dihydrofolate reductase enables sequential genetic manipulation of the Plasmodium berghei genome. Molecular and Biochemical Parasitology. 106: 199-212. PMID 10699250 DOI: 10.1016/S0166-6851(99)00189-9 |
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|
| 1999 |
Vinetz JM, Dave SK, Specht CA, Brameld KA, Xu B, Hayward R, Fidock DA. The chitinase PfCHT1 from the human malaria parasite Plasmodium falciparum lacks proenzyme and chitin-binding domains and displays unique substrate preferences Proceedings of the National Academy of Sciences of the United States of America. 96: 14061-14066. PMID 10570198 DOI: 10.1073/Pnas.96.24.14061 |
0.469 |
|
| 1999 |
Wellems TE, Su XZ, Ferdig M, Fidock DA. Genome projects, genetic analysis, and the changing landscape of malaria research Current Opinion in Microbiology. 2: 415-419. PMID 10458983 DOI: 10.1016/S1369-5274(99)80073-3 |
0.425 |
|
| 1999 |
Cociancich SO, Park SS, Fidock DA, Shahabuddin M. Vesicular ATPase-overexpressing cells determine the distribution of malaria parasite oocysts on the midguts of mosquitoes Journal of Biological Chemistry. 274: 12650-12655. PMID 10212245 DOI: 10.1074/Jbc.274.18.12650 |
0.304 |
|
| 1998 |
Fidock DA, Nomura T, Wellems TE. Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase Molecular Pharmacology. 54: 1140-1147. PMID 9855645 DOI: 10.1124/Mol.54.6.1140 |
0.523 |
|
| 1998 |
Wellems TE, Wootton JC, Fujioka H, Su XZ, Cooper R, Baruch D, Fidock DA. P. falciparum CG2, linked to chloroquine resistance, does not resemble Na+/H+ exchangers Cell. 94: 285-286. PMID 9708730 DOI: 10.1016/S0092-8674(00)81471-3 |
0.34 |
|
| 1998 |
Wellems T, Su X, Fidock D, Nomura T, Cooper R, Baruch D, Fujioka H. A candidate molecule for chloroquine resistance in Plasmodium falciparum malaria Parasitology International. 47: 17. DOI: 10.1016/S1383-5769(98)80009-3 |
0.353 |
|
| 1997 |
Fidock DA, Wellems TE. Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil Proceedings of the National Academy of Sciences of the United States of America. 94: 10931-10936. PMID 9380737 DOI: 10.1073/Pnas.94.20.10931 |
0.524 |
|
| 1997 |
Fidock DA, Pasquetto V, Gras H, Badell E, Eling W, Ballou WR, Belghiti J, Tartar A, Druilhe P. Plasmodium falciparum sporozoite invasion is inhibited by naturally acquired or experimentally induced polyclonal antibodies to the STARP antigen European Journal of Immunology. 27: 2502-2513. PMID 9368603 DOI: 10.1002/Eji.1830271007 |
0.338 |
|
| 1995 |
Aidoo M, Lalvani A, Allsopp CE, Plebanski M, Meisner SJ, Krausa P, Browning M, Morris-Jones S, Gotch F, Fidock DA. Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria. Lancet (London, England). 345: 1003-7. PMID 7536870 DOI: 10.1016/S0140-6736(95)90754-8 |
0.361 |
|
| 1994 |
Fidock DA, Bottius E, Brahimi K, Inge IMD, Moelans, Aikawa M, Konings RNH, Certa U, Olafsson P, Kaidoh T, Asavanich A, Guerin-Marchand C, Druilhe P. Cloning and characterization of a novel Plasmodium falciparum sporozoite surface antigen, STARP Molecular and Biochemical Parasitology. 64: 219-232. PMID 7935600 DOI: 10.1016/0166-6851(94)00012-3 |
0.381 |
|
| 1994 |
Fidock DA, Sallenave-Sales S, Sherwood JA, Gachihi GS, de Fatima Ferreira-da-Cruz M, Thomas AW, Druilhe P. Conservation of the Plasmodium falciparum sporozoite surface protein gene, STARP, in field isolates and distinct species of Plasmodium Molecular and Biochemical Parasitology. 67: 255-267. PMID 7870130 DOI: 10.1016/0166-6851(94)00138-3 |
0.358 |
|
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