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Dyann F. Wirth - Publications

Affiliations: 
Biological Sciences in Public Health Harvard University, Cambridge, MA, United States 
Area:
Parasitology Biology, Molecular Biology, Epidemiology
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Year Citation  Score
2023 Ullah I, Farringer MA, Burkhard AY, Hathaway E, Willett BC, Khushu M, Shin SH, Sharma AI, Shao KL, Martin MC, Dvorin JD, Hartl DL, Volkman SK, Bopp S, Absalon S, ... Wirth DF, et al. Artemisinin resistance mutations in impede hemoglobin uptake. Biorxiv : the Preprint Server For Biology. PMID 38187525 DOI: 10.1101/2023.12.22.572193  0.319
2023 Schaffner SF, Badiane A, Khorgade A, Ndiop M, Gomis J, Wong W, Ndiaye YD, Diedhiou Y, Thwing J, Seck MC, Early A, Sy M, Deme A, Diallo MA, Sy N, ... ... Wirth DF, et al. Malaria surveillance reveals parasite relatedness, signatures of selection, and correlates of transmission across Senegal. Nature Communications. 14: 7268. PMID 37949851 DOI: 10.1038/s41467-023-43087-4  0.351
2023 Mandt REK, Luth MR, Tye MA, Mazitschek R, Ottilie S, Winzeler EA, Lafuente-Monasterio MJ, Gamo FJ, Wirth DF, Lukens AK. Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance. Elife. 12. PMID 37737220 DOI: 10.7554/eLife.85023  0.731
2023 Ndiaye YD, Wong W, Thwing J, Schaffner SS, Tine A, Diallo MA, Deme A, Sy M, Bei AK, Thiaw AB, Daniels R, Ndiaye T, Gaye A, Ndiaye IM, Toure M, ... ... Wirth DF, et al. Two decades of molecular surveillance in Senegal reveal changes in known drug resistance mutations associated with historical drug use and seasonal malaria chemoprevention. Medrxiv : the Preprint Server For Health Sciences. PMID 37163114 DOI: 10.1101/2023.04.24.23288820  0.679
2023 Schaffner SF, Badiane A, Khorgade A, Ndiop M, Gomis J, Wong W, Ndiaye YD, Diedhiou Y, Thwing J, Seck MC, Early A, Sy M, Deme A, Diallo MA, Sy N, ... ... Wirth DF, et al. Malaria surveillance reveals parasite relatedness, signatures of selection, and correlates of transmission across Senegal. Medrxiv : the Preprint Server For Health Sciences. PMID 37131838 DOI: 10.1101/2023.04.11.23288401  0.375
2023 Bopp S, Pasaje CFA, Summers RL, Magistrado-Coxen P, Schindler KA, Corpas-Lopez V, Yeo T, Mok S, Dey S, Smick S, Nasamu AS, Demas AR, Milne R, Wiedemar N, Corey V, ... ... Wirth DF, et al. Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature Communications. 14: 1455. PMID 36927839 DOI: 10.1038/s41467-023-36921-2  0.749
2022 Wong W, Volkman S, Daniels R, Schaffner S, Sy M, Ndiaye YD, Badiane AS, Deme AB, Diallo MA, Gomis J, Sy N, Ndiaye D, Wirth DF, Hartl DL. : a genetic metric for measuring intrahost relatedness and distinguishing cotransmission from superinfection. Pnas Nexus. 1: pgac187. PMID 36246152 DOI: 10.1093/pnasnexus/pgac187  0.609
2022 Tye MA, Payne NC, Johansson C, Singh K, Santos SA, Fagbami L, Pant A, Sylvester K, Luth MR, Marques S, Whitman M, Mota MM, Winzeler EA, Lukens AK, Derbyshire ER, ... ... Wirth DF, et al. Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance. Nature Communications. 13: 4976. PMID 36008486 DOI: 10.1038/s41467-022-32630-4  0.716
2022 Paton DG, Probst AS, Ma E, Adams KL, Shaw WR, Singh N, Bopp S, Volkman SK, Hien DFS, Paré PSL, Yerbanga RS, Diabaté A, Dabiré RK, Lefèvre T, Wirth DF, et al. Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies. Plos Pathogens. 18: e1010609. PMID 35687594 DOI: 10.1371/journal.ppat.1010609  0.405
2022 Ottilie S, Luth MR, Hellemann E, Goldgof GM, Vigil E, Kumar P, Cheung AL, Song M, Godinez-Macias KP, Carolino K, Yang J, Lopez G, Abraham M, Tarsio M, LeBlanc E, ... ... Wirth DF, et al. Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance. Communications Biology. 5: 128. PMID 35149760 DOI: 10.1038/s42003-022-03076-7  0.71
2022 Sy M, Deme AB, Warren JL, Early A, Schaffner S, Daniels RF, Dieye B, Ndiaye IM, Diedhiou Y, Mbaye AM, Volkman SK, Hartl DL, Wirth DF, Ndiaye D, Bei AK. Plasmodium falciparum genomic surveillance reveals spatial and temporal trends, association of genetic and physical distance, and household clustering. Scientific Reports. 12: 938. PMID 35042879 DOI: 10.1038/s41598-021-04572-2  0.647
2021 Forte B, Ottilie S, Plater A, Campo B, Dechering KJ, Gamo FJ, Goldberg DE, Istvan ES, Lee M, Lukens AK, McNamara CW, Niles JC, Okombo J, Pasaje CFA, Siegel MG, ... Wirth D, et al. Prioritization of Molecular Targets for Antimalarial Drug Discovery. Acs Infectious Diseases. PMID 34523908 DOI: 10.1021/acsinfecdis.1c00322  0.681
2021 Summers RL, Pasaje CFA, Pisco JP, Striepen J, Luth MR, Kumpornsin K, Carpenter EF, Munro JT, Lin, Plater A, Punekar AS, Shepherd AM, Shepherd SM, Vanaerschot M, Murithi JM, ... ... Wirth DF, et al. Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. Cell Chemical Biology. PMID 34348113 DOI: 10.1016/j.chembiol.2021.07.010  0.73
2021 Ndiaye YD, Hartl DL, McGregor D, Badiane A, Fall FB, Daniels RF, Wirth DF, Ndiaye D, Volkman SK. Genetic surveillance for monitoring the impact of drug use on Plasmodium falciparum populations. International Journal For Parasitology. Drugs and Drug Resistance. 17: 12-22. PMID 34333350 DOI: 10.1016/j.ijpddr.2021.07.004  0.66
2021 Murithi JM, Deni I, Pasaje CFA, Okombo J, Bridgford JL, Gnädig NF, Edwards RL, Yeo T, Mok S, Burkhard AY, Coburn-Flynn O, Istvan ES, Sakata-Kato T, Gomez-Lorenzo MG, Cowell AN, ... ... Wirth DF, et al. The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance. Cell Chemical Biology. PMID 34233174 DOI: 10.1016/j.chembiol.2021.06.006  0.738
2021 Yang T, Ottilie S, Istvan ES, Godinez-Macias KP, Lukens AK, Baragaña B, Campo B, Walpole C, Niles JC, Chibale K, Dechering KJ, Llinás M, Lee MCS, Kato N, Wyllie S, ... ... Wirth DF, et al. MalDA, Accelerating Malaria Drug Discovery. Trends in Parasitology. PMID 33648890 DOI: 10.1016/j.pt.2021.01.009  0.701
2021 Kayode AT, Ajogbasile FV, Akano K, Uwanibe JN, Oluniyi PE, Eromon PJ, Folarin OA, Sowunmi A, Wirth DF, Happi CT. Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique. Scientific Reports. 11: 471. PMID 33436791 DOI: 10.1038/s41598-020-80017-6  0.326
2020 Sharma AI, Shin SH, Bopp S, Volkman SK, Hartl DL, Wirth DF. Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum. Plos Genetics. 16: e1009266. PMID 33370279 DOI: 10.1371/journal.pgen.1009266  0.346
2020 Kayode AT, Akano K, Ajogbasile FV, Uwanibe JN, Oluniyi PE, Bankole BE, Eromon PJ, Sowunmi A, Folarin OA, Volkman SK, McInnis B, Sabeti P, Wirth DF, Happi CT. Polymorphisms in Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and multidrug-resistant gene 1 (Pfmdr-1) in Nigerian children 10 years post-adoption of artemisinin-based combination treatments. International Journal For Parasitology. PMID 33359205 DOI: 10.1016/j.ijpara.2020.10.001  0.36
2020 Daniels RF, Chenet S, Rogier E, Lucchi N, Herman C, Pierre B, Lemoine JF, Boncy J, Wirth DF, Chang MA, Udhayakumar V, Volkman SK. Genetic analysis reveals unique characteristics of Plasmodium falciparum parasite populations in Haiti. Malaria Journal. 19: 379. PMID 33097045 DOI: 10.1186/s12936-020-03439-7  0.652
2020 Dewasurendra RL, Baniecki ML, Schaffner S, Siriwardena Y, Moon J, Doshi R, Gunawardena S, Daniels RF, Neafsey D, Volkman S, Chandrasekharan NV, Wirth DF, Karunaweera ND. Use of a Plasmodium vivax genetic barcode for genomic surveillance and parasite tracking in Sri Lanka. Malaria Journal. 19: 342. PMID 32958025 DOI: 10.1186/S12936-020-03386-3  0.691
2020 Daniels RF, Schaffner SF, Dieye Y, Dieng G, Hainsworth M, Fall FB, Diouf CN, Ndiop M, Cisse M, Gueye AB, Sarr O, Guinot P, Deme AB, Bei AK, Sy M, ... ... Wirth DF, et al. Genetic evidence for imported malaria and local transmission in Richard Toll, Senegal. Malaria Journal. 19: 276. PMID 32746830 DOI: 10.1186/S12936-020-03346-X  0.667
2020 Daniels RF, Schaffner SF, Bennett A, Porter TR, Yukich JO, Mulube C, Mambwe B, Mwenda MC, Chishimba S, Bridges DJ, Moonga H, Hamainza B, Chizema Kawesha E, Miller JM, Steketee RW, ... Wirth DF, et al. Evidence for Reduced Malaria Parasite Population after Application of Population-Level Antimalarial Drug Strategies in Southern Province, Zambia. The American Journal of Tropical Medicine and Hygiene. PMID 32618255 DOI: 10.4269/Ajtmh.19-0666  0.694
2020 McPhillie M, Zhou Y, El Bissati K, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, ... ... Wirth D, et al. Author Correction: New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. Scientific Reports. 10: 5512. PMID 32251362 DOI: 10.1038/S41598-020-62323-1  0.654
2019 Meibalan E, Barry A, Gibbins MP, Awandu S, Meerstein-Kessel L, Achcar F, Bopp S, Moxon C, Diarra A, Debe S, Ouédraogo N, Barry-Some I, Badoum E, Fagnima T, Lanke K, ... ... Wirth D, et al. P. falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers in Burkina Faso. The Journal of Infectious Diseases. PMID 31875909 DOI: 10.1093/Infdis/Jiz680  0.35
2019 Chen AJ, Huang KC, Bopp S, Summers R, Dong P, Huang Y, Zong C, Wirth D, Cheng JX. Quantitative imaging of intraerythrocytic hemozoin by transient absorption microscopy. Journal of Biomedical Optics. 25: 1-11. PMID 31849205 DOI: 10.1117/1.Jbo.25.1.014507  0.379
2019 Mandt REK, Lafuente-Monasterio MJ, Sakata-Kato T, Luth MR, Segura D, Pablos-Tanarro A, Viera S, Magan N, Ottilie S, Winzeler EA, Lukens AK, Gamo FJ, Wirth DF. In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model. Science Translational Medicine. 11. PMID 31801884 DOI: 10.1126/Scitranslmed.Aav1636  0.757
2019 Diédhiou CK, Moussa RA, Bei AK, Daniels R, Papa Mze N, Ndiaye D, Faye N, Wirth D, Amambua-Ngwa A, Mboup S, Ahouidi AD. Temporal changes in Plasmodium falciparum reticulocyte binding protein homolog 2b (PfRh2b) in Senegal and The Gambia. Malaria Journal. 18: 239. PMID 31311552 DOI: 10.1186/S12936-019-2868-X  0.641
2019 Early AM, Daniels RF, Farrell TM, Grimsby J, Volkman SK, Wirth DF, MacInnis BL, Neafsey DE. Detection of low-density Plasmodium falciparum infections using amplicon deep sequencing. Malaria Journal. 18: 219. PMID 31262308 DOI: 10.1186/S12936-019-2856-1  0.638
2019 Sharma AI, Demas AR, Hartl DL, Wirth DF. Reply to Velavan et al.: Polymorphisms of in natural populations: Implications for functional significance. Proceedings of the National Academy of Sciences of the United States of America. 116: 12613-12614. PMID 31239364 DOI: 10.1073/Pnas.1907920116  0.307
2019 Dantzler KW, Ma S, Ngotho P, Stone WJR, Tao D, Rijpma S, De Niz M, Nilsson Bark SK, Jore MM, Raaijmakers TK, Early AM, Ubaida-Mohien C, Lemgruber L, Campo JJ, Teng AA, ... ... Wirth DF, et al. Naturally acquired immunity against immature gametocytes. Science Translational Medicine. 11. PMID 31167926 DOI: 10.1126/Scitranslmed.Aav3963  0.378
2019 Fagbami L, Deik AA, Herman JD, Singh K, Santos SA, Bopp S, Lukens AK, Clish CB, Wirth DF, Mazitschek R. The adaptive proline response in P. falciparum is independent of PfeIK1 and eIF2α signaling. Acs Infectious Diseases. PMID 30773881 DOI: 10.1021/Acsinfecdis.8B00363  0.735
2018 Bankole BE, Kayode AT, Nosamiefan IO, Eromon P, Baniecki ML, Daniels RF, Hamilton EJ, Durfee K, MacInnis B, Okafor H, Sowunmi A, Volkman SK, Sabeti P, Wirth D, Happi CT, et al. Characterization of Plasmodium falciparum structure in Nigeria with malaria SNPs barcode. Malaria Journal. 17: 472. PMID 30558627 DOI: 10.1186/S12936-018-2623-8  0.706
2018 Antonova-Koch Y, Meister S, Abraham M, Luth MR, Ottilie S, Lukens AK, Sakata-Kato T, Vanaerschot M, Owen E, Jado Rodriguez JC, Maher SP, Calla J, Plouffe D, Zhong Y, Chen K, ... ... Wirth DF, et al. Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science (New York, N.Y.). 362. PMID 30523084 DOI: 10.1126/Science.Aat9446  0.727
2018 Demas AR, Sharma AI, Wong W, Early AM, Redmond S, Bopp S, Neafsey DE, Volkman SK, Hartl DL, Wirth DF. Mutations in actin-binding protein coronin confer reduced artemisinin susceptibility. Proceedings of the National Academy of Sciences of the United States of America. PMID 30420498 DOI: 10.1073/Pnas.1812317115  0.458
2018 Schaffner SF, Taylor AR, Wong W, Wirth DF, Neafsey DE. hmmIBD: software to infer pairwise identity by descent between haploid genotypes. Malaria Journal. 17: 196. PMID 29764422 DOI: 10.1186/S12936-018-2349-7  0.397
2018 Obaldia N, Meibalan E, Sa JM, Ma S, Clark MA, Mejia P, Moraes Barros RR, Otero W, Ferreira MU, Mitchell JR, Milner DA, Huttenhower C, Wirth DF, Duraisingh MT, Wellems TE, et al. Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection. Mbio. 9. PMID 29739900 DOI: 10.1128/Mbio.00625-18  0.384
2018 Grignard L, Gonçalves BP, Early AM, Daniels RF, Tiono AB, Guelbéogo WM, Ouédraogo A, van Veen EM, Lanke K, Diarra A, Nebie I, Sirima SB, Targett GA, Volkman SK, Neafsey DE, ... Wirth DF, et al. Transmission of molecularly undetectable circulating parasite clones leads to high infection complexity in mosquitoes post feeding. International Journal For Parasitology. PMID 29738740 DOI: 10.1016/J.Ijpara.2018.02.005  0.67
2018 Redmond SN, MacInnis BM, Bopp S, Bei AK, Ndiaye D, Hartl DL, Wirth DF, Volkman SK, Neafsey DE. De Novo Mutations Resolve Disease Transmission Pathways in Clonal Malaria. Molecular Biology and Evolution. PMID 29722884 DOI: 10.1093/Molbev/Msy059  0.372
2018 Bopp S, Magistrado P, Wong W, Schaffner SF, Mukherjee A, Lim P, Dhorda M, Amaratunga C, Woodrow CJ, Ashley EA, White NJ, Dondorp AM, Fairhurst RM, Ariey F, Menard D, ... Wirth DF, et al. Plasmepsin II-III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum. Nature Communications. 9: 1769. PMID 29720620 DOI: 10.1038/S41467-018-04104-Z  0.411
2018 Early AM, Lievens M, MacInnis BL, Ockenhouse CF, Volkman SK, Adjei S, Agbenyega T, Ansong D, Gondi S, Greenwood B, Hamel M, Odero C, Otieno K, Otieno W, Owusu-Agyei S, ... ... Wirth DF, et al. Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections. Nature Communications. 9: 1381. PMID 29643376 DOI: 10.1038/S41467-018-03807-7  0.439
2018 Mukherjee A, Gagnon D, Wirth DF, Richard D. Inactivation of Plasmepsin 2 and 3 sensitizesto the antimalarial drug piperaquine. Antimicrobial Agents and Chemotherapy. PMID 29439977 DOI: 10.1128/Aac.02309-17  0.411
2018 Ross LS, Lafuente-Monasterio MJ, Sakata-Kato T, Mandt REK, Gamo FJ, Wirth DF, Lukens AK. Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum. Acs Infectious Diseases. PMID 29336544 DOI: 10.1021/Acsinfecdis.7B00217  0.803
2018 Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, ... ... Wirth DF, et al. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science (New York, N.Y.). 359: 191-199. PMID 29326268 DOI: 10.1126/Science.Aan4472  0.777
2018 Bei AK, Niang M, Deme AB, Daniels RF, Sarr FD, Sokhna C, Talla C, Faye J, Diagne N, Doucoure S, Mboup S, Wirth DF, Tall A, Ndiaye D, Hartl DL, et al. Dramatic Changes in Malaria Population Genetic Complexity in Dielmo and Ndiop, Senegal, Revealed Using Genomic Surveillance. The Journal of Infectious Diseases. PMID 29325146 DOI: 10.1093/Infdis/Jix580  0.673
2018 Wong W, Wenger EA, Hartl DL, Wirth DF. Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission. Plos Computational Biology. 14: e1005923. PMID 29315306 DOI: 10.1371/Journal.Pcbi.1005923  0.357
2017 Rabinovich RN, Drakeley C, Djimde AA, Hall BF, Hay SI, Hemingway J, Kaslow DC, Noor A, Okumu F, Steketee R, Tanner M, Wells TNC, Whittaker MA, Winzeler EA, Wirth DF, et al. malERA: An updated research agenda for malaria elimination and eradication. Plos Medicine. 14: e1002456. PMID 29190300 DOI: 10.1371/Journal.Pmed.1002456  0.379
2017 Wirth DF, Winzeler EA, Fenton B, Adams JH, Ariey F, Barillas-Mury CV, Baum J, Bhatia SN, Billker O, Bopp SE, Catteruccia F, Cowman AF, Chitnis CE, Crabb BS, Deitsch KW, et al. malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication Plos Medicine. 14. PMID 29190277 DOI: 10.1371/Journal.Pmed.1002451  0.674
2017 Nilsson Bark SK, Ahmad R, Dantzler K, Lukens AK, De Niz M, Szucs MJ, Jin X, Cotton J, Hoffmann D, Bric-Furlong E, Oomen R, Parrington M, Milner D, Neafsey DE, Carr SA, ... Wirth DF, et al. Quantitative proteomic profiling reveals novel Plasmodium falciparum surface antigens and possible vaccine candidates. Molecular & Cellular Proteomics : McP. PMID 29162636 DOI: 10.1074/Mcp.Ra117.000076  0.726
2017 Brancucci NMB, Gerdt JP, Wang C, De Niz M, Philip N, Adapa SR, Zhang M, Hitz E, Niederwieser I, Boltryk SD, Laffitte MC, Clark MA, Grüring C, Ravel D, Blancke Soares A, ... ... Wirth DF, et al. Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum. Cell. PMID 29129376 DOI: 10.1016/J.Cell.2017.10.020  0.397
2017 Gonçalves BP, Kapulu MC, Sawa P, Guelbéogo WM, Tiono AB, Grignard L, Stone W, Hellewell J, Lanke K, Bastiaens GJH, Bradley J, Nébié I, Ngoi JM, Oriango R, Mkabili D, ... ... Wirth DF, et al. Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity. Nature Communications. 8: 1133. PMID 29074880 DOI: 10.1038/S41467-017-01270-4  0.423
2017 Mukherjee A, Bopp S, Magistrado P, Wong W, Daniels R, Demas A, Schaffner S, Amaratunga C, Lim P, Dhorda M, Miotto O, Woodrow C, Ashley EA, Dondorp AM, White NJ, ... Wirth D, et al. Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia. Malaria Journal. 16: 195. PMID 28494763 DOI: 10.1186/S12936-017-1845-5  0.673
2017 Gunawardena S, Daniels RF, Yahathugoda TC, Weerasooriya MV, Durfee K, Volkman SK, Wirth DF, Karunaweera ND. Case report of Plasmodium ovale curtisi malaria in Sri Lanka: relevance for the maintenance of elimination status. Bmc Infectious Diseases. 17: 307. PMID 28438137 DOI: 10.1186/S12879-017-2411-Z  0.659
2017 Ndiaye YD, Diédhiou CK, Bei AK, Dieye B, Mbaye A, Mze NP, Daniels RF, Ndiaye IM, Déme AB, Gaye A, Sy M, Ndiaye T, Badiane AS, Ndiaye M, Premji Z, ... Wirth DF, et al. High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations. Malaria Journal. 16: 153. PMID 28420422 DOI: 10.1186/S12936-017-1811-2  0.681
2017 Wong W, Griggs AD, Daniels RF, Schaffner SF, Ndiaye D, Bei AK, Deme AB, MacInnis B, Volkman SK, Hartl DL, Neafsey DE, Wirth DF. Genetic relatedness analysis reveals the cotransmission of genetically related Plasmodium falciparum parasites in Thiès, Senegal. Genome Medicine. 9: 5. PMID 28118860 DOI: 10.1186/S13073-017-0398-0  0.644
2017 Daniels RF, Deme AB, Gomis JF, Dieye B, Durfee K, Thwing JI, Fall FB, Ba M, Ndiop M, Badiane AS, Ndiaye YD, Wirth DF, Volkman SK, Ndiaye D. Evidence of non-Plasmodium falciparum malaria infection in Kédougou, Sénégal. Malaria Journal. 16: 9. PMID 28049489 DOI: 10.1186/S12936-016-1661-3  0.677
2016 Vunnam S, Reddy A, Mazitschek R, Lukens AK, Wirth DF, Li L, Naumov P, O'Connor MJ, Al-Tel TH. Intramolecular Diaza-Diels-Alder Protocol: A Novel Diastereoselective and Modular One-Step Synthesis of Constrained Polycyclic Frameworks. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27997727 DOI: 10.1002/Chem.201605231  0.719
2016 Magistrado PA, Corey VC, Lukens AK, LaMonte G, Sasaki E, Meister S, Wree M, Winzeler E, Wirth DF. Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes. Acs Infectious Diseases. 2: 816-826. PMID 27933786 DOI: 10.1021/Acsinfecdis.6B00025  0.743
2016 Sakata-Kato T, Wirth DF. A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors. Acs Infectious Diseases. PMID 27718558 DOI: 10.1021/Acsinfecdis.6B00101  0.382
2016 Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan G, Duffy S, Eckley S, ... ... Wirth DF, et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. PMID 27602946 DOI: 10.1038/Nature19804  0.72
2016 Dieye B, Affara M, Sangare L, Joof F, Ndiaye YD, Gomis JF, Ndiaye M, Mbaye A, Diakite M, Sy N, Mbengue B, Deme AB, Daniels R, Ahouidi AD, Dieye T, ... ... Wirth DF, et al. West Africa International Centers of Excellence for Malaria Research: Drug Resistance Patterns to Artemether-Lumefantrine in Senegal, Mali, and The Gambia. The American Journal of Tropical Medicine and Hygiene. PMID 27549635 DOI: 10.4269/Ajtmh.16-0053  0.682
2016 Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, Wirth DF, André V, Duarte MT, Guedes RC, J V A Dos Santos D, Rosenthal PJ, Mazitschek R, Prudêncio M, Moreira R. Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites. Chemmedchem. PMID 27538856 DOI: 10.1002/Cmdc.201600327  0.737
2016 McPhillie M, Zhou Y, El Bissati K, Dubey J, Lorenzi H, Capper M, Lukens AK, Hickman M, Muench S, Verma SK, Weber CR, Wheeler K, Gordon J, Sanders J, Moulton H, ... ... Wirth D, et al. New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections. Scientific Reports. 6: 29179. PMID 27412848 DOI: 10.1038/Srep29179  0.724
2016 Corey VC, Lukens AK, Istvan ES, Lee MC, Franco V, Magistrado P, Coburn-Flynn O, Sakata-Kato T, Fuchs O, Gnädig NF, Goldgof G, Linares M, Gomez-Lorenzo MG, De Cózar C, Lafuente-Monasterio MJ, ... ... Wirth DF, et al. A broad analysis of resistance development in the malaria parasite. Nature Communications. 7: 11901. PMID 27301419 DOI: 10.1038/Ncomms11901  0.744
2016 Chang HH, Meibalan E, Zelin J, Daniels R, Eziefula AC, Meyer EC, Tadesse F, Grignard L, Joice RC, Drakeley C, Wirth DF, Volkman SK, Buckee C, Bousema T, Marti M. Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda. Scientific Reports. 6: 26330. PMID 27197604 DOI: 10.1038/Srep26330  0.679
2016 Obaldía Iii N, Dow GS, Gerena L, Kyle D, Otero W, Mantel PY, Baro N, Daniels R, Mukherjee A, Childs LM, Buckee C, Duraisingh MT, Volkman SK, Wirth DF, Marti M. Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model. Scientific Reports. 6: 21216. PMID 26880111 DOI: 10.1038/Srep21216  0.717
2015 Daniels R, Hamilton EJ, Durfee K, Ndiaye D, Wirth DF, Hartl DL, Volkman SK. Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria. Journal of Visualized Experiments : Jove. PMID 26575471 DOI: 10.3791/52839  0.709
2015 Neafsey DE, Juraska M, Bedford T, Benkeser D, Valim C, Griggs A, Lievens M, Abdulla S, Adjei S, Agbenyega T, Agnandji ST, Aide P, Anderson S, Ansong D, Aponte JJ, ... ... Wirth DF, et al. Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine. The New England Journal of Medicine. PMID 26488565 DOI: 10.1056/Nejmoa1505819  0.31
2015 Papa Mze N, Ndiaye YD, Diedhiou CK, Rahamatou S, Dieye B, Daniels RF, Hamilton EJ, Diallo M, Bei AK, Wirth DF, Mboup S, Volkman SK, Ahouidi AD, Ndiaye D. RDTs as a source of DNA to study Plasmodium falciparum drug resistance in isolates from Senegal and the Comoros Islands. Malaria Journal. 14: 373. PMID 26415927 DOI: 10.1186/S12936-015-0861-6  0.673
2015 Santos SA, Lukens AK, Coelho L, Nogueira F, Wirth DF, Mazitschek R, Moreira R, Paulo A. Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype. European Journal of Medicinal Chemistry. 102: 320-33. PMID 26295174 DOI: 10.1016/J.Ejmech.2015.07.047  0.735
2015 Pelleau S, Moss EL, Dhingra SK, Volney B, Casteras J, Gabryszewski SJ, Volkman SK, Wirth DF, Legrand E, Fidock DA, Neafsey DE, Musset L. Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt. Proceedings of the National Academy of Sciences of the United States of America. 112: 11672-7. PMID 26261345 DOI: 10.1073/Pnas.1507142112  0.48
2015 Broadbent KM, Broadbent JC, Ribacke U, Wirth D, Rinn JL, Sabeti PC. Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA. Bmc Genomics. 16: 454. PMID 26070627 DOI: 10.1186/S12864-015-1603-4  0.361
2015 Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, ... ... Wirth DF, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Science Translational Medicine. 7: 288ra77. PMID 25995223 DOI: 10.1126/Scitranslmed.Aaa3575  0.773
2015 Daniels RF, Schaffner SF, Wenger EA, Proctor JL, Chang HH, Wong W, Baro N, Ndiaye D, Fall FB, Ndiop M, Ba M, Milner DA, Taylor TE, Neafsey DE, Volkman SK, ... ... Wirth DF, et al. Modeling malaria genomics reveals transmission decline and rebound in Senegal. Proceedings of the National Academy of Sciences of the United States of America. 112: 7067-72. PMID 25941365 DOI: 10.1073/Pnas.1505691112  0.677
2015 Hameed P S, Solapure S, Patil V, Henrich PP, Magistrado PA, Bharath S, Murugan K, Viswanath P, Puttur J, Srivastava A, Bellale E, Panduga V, Shanbag G, Awasthy D, Landge S, ... ... Wirth DF, et al. Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate. Nature Communications. 6: 6715. PMID 25823686 DOI: 10.1038/Ncomms7715  0.727
2015 Baniecki ML, Faust AL, Schaffner SF, Park DJ, Galinsky K, Daniels RF, Hamilton E, Ferreira MU, Karunaweera ND, Serre D, Zimmerman PA, Sá JM, Wellems TE, Musset L, Legrand E, ... ... Wirth DF, et al. Development of a single nucleotide polymorphism barcode to genotype Plasmodium vivax infections. Plos Neglected Tropical Diseases. 9: e0003539. PMID 25781890 DOI: 10.1371/Journal.Pntd.0003539  0.689
2015 Mejia P, Treviño-Villarreal JH, Hine C, Harputlugil E, Lang S, Calay E, Rogers R, Wirth D, Duraisingh MT, Mitchell JR. Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression. Nature Communications. 6: 6050. PMID 25636003 DOI: 10.1038/Ncomms7050  0.369
2015 Galinsky K, Valim C, Salmier A, de Thoisy B, Musset L, Legrand E, Faust A, Baniecki ML, Ndiaye D, Daniels RF, Hartl DL, Sabeti PC, Wirth DF, Volkman SK, Neafsey DE. COIL: a methodology for evaluating malarial complexity of infection using likelihood from single nucleotide polymorphism data. Malaria Journal. 14: 4. PMID 25599890 DOI: 10.1186/1475-2875-14-4  0.631
2015 Bei AK, Diouf A, Miura K, Larremore DB, Ribacke U, Tullo G, Moss EL, Neafsey DE, Daniels RF, Zeituni AE, Nosamiefan I, Volkman SK, Ahouidi AD, Ndiaye D, Dieye T, ... ... Wirth DF, et al. Immune characterization of Plasmodium falciparum parasites with a shared genetic signature in a region of decreasing transmission. Infection and Immunity. 83: 276-85. PMID 25368109 DOI: 10.1128/Iai.01979-14  0.697
2015 Lukens AK, Heidebrecht RW, Mulrooney C, Beaudoin JA, Comer E, Duvall JR, Fitzgerald ME, Masi D, Galinsky K, Scherer CA, Palmer M, Munoz B, Foley M, Schreiber SL, Wiegand RC, ... Wirth DF, et al. Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors. The Journal of Infectious Diseases. 211: 1097-103. PMID 25336726 DOI: 10.1093/Infdis/Jiu565  0.723
2015 Obaldia N, Baro NK, Calzada JE, Santamaria AM, Daniels R, Wong W, Chang HH, Hamilton EJ, Arevalo-Herrera M, Herrera S, Wirth DF, Hartl DL, Marti M, Volkman SK. Clonal outbreak of Plasmodium falciparum infection in eastern Panama. The Journal of Infectious Diseases. 211: 1087-96. PMID 25336725 DOI: 10.1093/Infdis/Jiu575  0.719
2015 Kumar AA, Lim C, Moreno Y, Mace CR, Syed A, Van Tyne D, Wirth DF, Duraisingh MT, Whitesides GM. Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers. American Journal of Hematology. 90: 31-6. PMID 25263455 DOI: 10.1002/Ajh.23860  0.645
2015 Volkman S, Daniels R, Chang H, Park D, Neafsey D, Schaffner S, Lukens A, Mboup S, Sabeti P, Wirth D, Hartl D. Genotyping malaria parasites to understand malaria transmission Annals of Global Health. 81: 82. DOI: 10.1016/J.Aogh.2015.02.694  0.805
2014 Van Tyne D, Tan Y, Daily JP, Kamiza S, Seydel K, Taylor T, Mesirov JP, Wirth DF, Milner DA. Plasmodium falciparum gene expression measured directly from tissue during human infection. Genome Medicine. 6: 110. PMID 25520756 DOI: 10.1186/S13073-014-0110-6  0.665
2014 Herman JD, Rice DP, Ribacke U, Silterra J, Deik AA, Moss EL, Broadbent KM, Neafsey DE, Desai MM, Clish CB, Mazitschek R, Wirth DF. A genomic and evolutionary approach reveals non-genetic drug resistance in malaria. Genome Biology. 15: 511. PMID 25395010 DOI: 10.1186/S13059-014-0511-2  0.481
2014 Comer E, Beaudoin JA, Kato N, Fitzgerald ME, Heidebrecht RW, Lee Md, Masi D, Mercier M, Mulrooney C, Muncipinto G, Rowley A, Crespo-Llado K, Serrano AE, Lukens AK, Wiegand RC, ... Wirth DF, et al. Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents. Journal of Medicinal Chemistry. 57: 8496-502. PMID 25211597 DOI: 10.1021/Jm500994N  0.697
2014 Hameed P S, Chinnapattu M, Shanbag G, Manjrekar P, Koushik K, Raichurkar A, Patil V, Jatheendranath S, Rudrapatna SS, Barde SP, Rautela N, Awasthy D, Morayya S, Narayan C, Kavanagh S, ... ... Wirth DF, et al. Aminoazabenzimidazoles, a novel class of orally active antimalarial agents. Journal of Medicinal Chemistry. 57: 5702-13. PMID 24914738 DOI: 10.1021/Jm500535J  0.725
2014 Ross LS, Gamo FJ, Lafuente-Monasterio MJ, Singh OM, Rowland P, Wiegand RC, Wirth DF. In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth. The Journal of Biological Chemistry. 289: 17980-95. PMID 24782313 DOI: 10.1074/Jbc.M114.558353  0.692
2014 Mharakurwa S, Daniels R, Scott A, Wirth DF, Thuma P, Volkman SK. Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia. Malaria Journal. 13: 89. PMID 24618119 DOI: 10.1186/1475-2875-13-89  0.656
2014 Bei AK, Patel SD, Volkman SK, Ahouidi AD, Ndiaye D, Mboup S, Wirth DF. An adjustable gas-mixing device to increase feasibility of in vitro culture of Plasmodium falciparum parasites in the field. Plos One. 9: e90928. PMID 24603696 DOI: 10.1371/Journal.Pone.0090928  0.334
2014 Karunaweera ND, Galappaththy GN, Wirth DF. On the road to eliminate malaria in Sri Lanka: lessons from history, challenges, gaps in knowledge and research needs. Malaria Journal. 13: 59. PMID 24548783 DOI: 10.1186/1475-2875-13-59  0.393
2014 Gunawardena S, Ferreira MU, Kapilananda GM, Wirth DF, Karunaweera ND. The Sri Lankan paradox: high genetic diversity in Plasmodium vivax populations despite decreasing levels of malaria transmission. Parasitology. 141: 880-90. PMID 24533989 DOI: 10.1017/S0031182013002278  0.344
2014 Deme AB, Park DJ, Bei AK, Sarr O, Badiane AS, Gueye Pel H, Ahouidi A, Ndir O, Mboup S, Wirth DF, Ndiaye D, Volkman SK. Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests. Malaria Journal. 13: 34. PMID 24472178 DOI: 10.1186/1475-2875-13-34  0.428
2014 Lukens AK, Ross LS, Heidebrecht R, Javier Gamo F, Lafuente-Monasterio MJ, Booker ML, Hartl DL, Wiegand RC, Wirth DF. Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance. Proceedings of the National Academy of Sciences of the United States of America. 111: 799-804. PMID 24381157 DOI: 10.1073/Pnas.1320886110  0.811
2014 Rowland P, SINGH O, Ross L, Gamo F, Lafuente-Monasterio M, Wiegand R, Wirth D. Plasmodium falciparum DHODH inhibitor complexes reveal flexible binding site Acta Crystallographica Section a Foundations and Advances. 70: C1793-C1793. DOI: 10.1107/S2053273314082072  0.675
2013 Ndiaye D, Dieye B, Ndiaye YD, Van Tyne D, Daniels R, Bei AK, Mbaye A, Valim C, Lukens A, Mboup S, Ndir O, Wirth DF, Volkman S. Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal. International Journal For Parasitology. Drugs and Drug Resistance. 3: 135-42. PMID 24533303 DOI: 10.1016/J.Ijpddr.2013.07.001  0.827
2013 Joice R, Narasimhan V, Montgomery J, Sidhu AB, Oh K, Meyer E, Pierre-Louis W, Seydel K, Milner D, Williamson K, Wiegand R, Ndiaye D, Daily J, Wirth D, Taylor T, et al. Inferring developmental stage composition from gene expression in human malaria. Plos Computational Biology. 9: e1003392. PMID 24348235 DOI: 10.1371/Journal.Pcbi.1003392  0.391
2013 Van Tyne D, Dieye B, Valim C, Daniels RF, Sène PD, Lukens AK, Ndiaye M, Bei AK, Ndiaye YD, Hamilton EJ, Ndir O, Mboup S, Volkman SK, Wirth DF, Ndiaye D. Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal. Malaria Journal. 12: 441. PMID 24314037 DOI: 10.1186/1475-2875-12-441  0.829
2013 Chang HH, Moss EL, Park DJ, Ndiaye D, Mboup S, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL. Malaria life cycle intensifies both natural selection and random genetic drift. Proceedings of the National Academy of Sciences of the United States of America. 110: 20129-34. PMID 24259712 DOI: 10.1073/Pnas.1319857110  0.397
2013 Hanson KK, Ressurreição AS, Buchholz K, Prudêncio M, Herman-Ornelas JD, Rebelo M, Beatty WL, Wirth DF, Hänscheid T, Moreira R, Marti M, Mota MM. Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: E2838-47. PMID 23836641 DOI: 10.1073/Pnas.1306097110  0.365
2013 Daniels R, Chang HH, Séne PD, Park DC, Neafsey DE, Schaffner SF, Hamilton EJ, Lukens AK, Van Tyne D, Mboup S, Sabeti PC, Ndiaye D, Wirth DF, Hartl DL, Volkman SK. Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal. Plos One. 8: e60780. PMID 23593309 DOI: 10.1371/Journal.Pone.0060780  0.823
2013 Van Tyne D, Uboldi AD, Healer J, Cowman AF, Wirth DF. Modulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugs. Antimicrobial Agents and Chemotherapy. 57: 2937-41. PMID 23587962 DOI: 10.1128/Aac.02574-12  0.736
2012 Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler EA, Wirth DF, Duraisingh MT. Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host & Microbe. 12: 739-50. PMID 23245319 DOI: 10.1016/J.Chom.2012.11.004  0.368
2012 Park DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C, Ribacke U, Van Tyne D, Galinsky K, Galligan M, Becker JS, Ndiaye D, Mboup S, Wiegand RC, Hartl DL, ... ... Wirth DF, et al. Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proceedings of the National Academy of Sciences of the United States of America. 109: 13052-7. PMID 22826220 DOI: 10.1073/Pnas.1210585109  0.831
2012 Milner DA, Pochet N, Krupka M, Williams C, Seydel K, Taylor TE, Van de Peer Y, Regev A, Wirth D, Daily JP, Mesirov JP. Transcriptional profiling of Plasmodium falciparum parasites from patients with severe malaria identifies distinct low vs. high parasitemic clusters. Plos One. 7: e40739. PMID 22815802 DOI: 10.1371/Journal.Pone.0040739  0.432
2012 Chang HH, Park DJ, Galinsky KJ, Schaffner SF, Ndiaye D, Ndir O, Mboup S, Wiegand RC, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL. Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population. Molecular Biology and Evolution. 29: 3427-39. PMID 22734050 DOI: 10.1093/Molbev/Mss161  0.454
2012 Ly O, Gueye PE, Deme AB, Dieng T, Badiane AS, Ahouidi AD, Diallo M, Bei AK, Wirth DF, Mboup S, Sarr O. Evolution of the pfcrt T76 and pfmdr1 Y86 markers and chloroquine susceptibility 8 years after cessation of chloroquine use in Pikine, Senegal. Parasitology Research. 111: 1541-6. PMID 22706959 DOI: 10.1007/S00436-012-2994-7  0.376
2012 Amambua-Ngwa A, Park DJ, Volkman SK, Barnes KG, Bei AK, Lukens AK, Sene P, Van Tyne D, Ndiaye D, Wirth DF, Conway DJ, Neafsey DE, Schaffner SF. SNP genotyping identifies new signatures of selection in a deep sample of West African Plasmodium falciparum malaria parasites. Molecular Biology and Evolution. 29: 3249-53. PMID 22688945 DOI: 10.1093/Molbev/Mss151  0.819
2012 Bustamante C, Folarin OA, Gbotosho GO, Batista CN, Mesquita EA, Brindeiro RM, Tanuri A, Struchiner CJ, Sowunmi A, Oduola A, Wirth DF, Zalis MG, Happi CT. In vitro-reduced susceptibility to artemether in P. falciparum and its association with polymorphisms on transporter genes. The Journal of Infectious Diseases. 206: 324-32. PMID 22615315 DOI: 10.1093/Infdis/Jis359  0.405
2012 Volkman SK, Neafsey DE, Schaffner SF, Park DJ, Wirth DF. Harnessing genomics and genome biology to understand malaria biology. Nature Reviews. Genetics. 13: 315-28. PMID 22495435 DOI: 10.1038/Nrg3187  0.462
2012 Daniels R, Ndiaye D, Wall M, McKinney J, Séne PD, Sabeti PC, Volkman SK, Mboup S, Wirth DF. Rapid, field-deployable method for genotyping and discovery of single-nucleotide polymorphisms associated with drug resistance in Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 56: 2976-86. PMID 22430961 DOI: 10.1128/Aac.05737-11  0.724
2012 Heidebrecht RW, Mulrooney C, Austin CP, Barker RH, Beaudoin JA, Cheng KC, Comer E, Dandapani S, Dick J, Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M, Guha R, ... ... Wirth D, et al. Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria. Acs Medicinal Chemistry Letters. 3: 112-117. PMID 22328964 DOI: 10.1021/Ml200244K  0.715
2012 Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, Kim YJ, Lee HK, Cortese JF, Wirth DF, Dignam JD, Rao A, Yeo CY, Mazitschek R, Whitman M. Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nature Chemical Biology. 8: 311-7. PMID 22327401 DOI: 10.1038/Nchembio.790  0.31
2012 Milner DA, Vareta J, Valim C, Montgomery J, Daniels RF, Volkman SK, Neafsey DE, Park DJ, Schaffner SF, Mahesh NC, Barnes KG, Rosen DM, Lukens AK, Van Tyne D, Wiegand RC, ... ... Wirth DF, et al. Human cerebral malaria and Plasmodium falciparum genotypes in Malawi. Malaria Journal. 11: 35. PMID 22314206 DOI: 10.1186/1475-2875-11-35  0.811
2012 Volkman SK, Ndiaye D, Diakite M, Koita OA, Nwakanma D, Daniels RF, Park DJ, Neafsey DE, Muskavitch MA, Krogstad DJ, Sabeti PC, Hartl DL, Wirth DF. Application of genomics to field investigations of malaria by the international centers of excellence for malaria research. Acta Tropica. 121: 324-32. PMID 22182668 DOI: 10.1016/J.Actatropica.2011.12.002  0.686
2012 Doumbia SO, Ndiaye D, Koita OA, Diakité M, Nwakanma D, Coulibaly M, Traoré SF, Keating J, Milner DA, Ndiaye JL, Sene PD, Ahouidi A, Dieye TN, Gaye O, Okebe J, ... ... Wirth DF, et al. Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Tropica. 121: 175-83. PMID 22142790 DOI: 10.1016/J.Actatropica.2011.11.009  0.616
2012 Ceesay SJ, Bojang KA, Nwakanma D, Conway DJ, Koita OA, Doumbia SO, Ndiaye D, Coulibaly TF, Diakité M, Traoré SF, Coulibaly M, Ndiaye JL, Sarr O, Gaye O, Konaté L, ... ... Wirth DF, et al. Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Tropica. 121: 166-74. PMID 22119584 DOI: 10.1016/J.Actatropica.2011.11.005  0.406
2011 Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, ... ... Wirth DF, et al. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chemistry & Biology. 18: 1602-10. PMID 22195562 DOI: 10.1016/J.Chembiol.2011.09.016  0.828
2011 Zhang JJ, Senaratne TN, Daniels R, Valim C, Alifrangis M, Amerasinghe P, Konradsen F, Rajakaruna R, Wirth DF, Karunaweera ND. Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006. The American Journal of Tropical Medicine and Hygiene. 85: 811-4. PMID 22049031 DOI: 10.4269/Ajtmh.2011.11-0167  0.69
2011 Melnikov A, Galinsky K, Rogov P, Fennell T, Van Tyne D, Russ C, Daniels R, Barnes KG, Bochicchio J, Ndiaye D, Sene PD, Wirth DF, Nusbaum C, Volkman SK, Birren BW, et al. Hybrid selection for sequencing pathogen genomes from clinical samples. Genome Biology. 12: R73. PMID 21835008 DOI: 10.1186/Gb-2011-12-8-R73  0.755
2011 Broadbent KM, Park D, Wolf AR, Van Tyne D, Sims JS, Ribacke U, Volkman S, Duraisingh M, Wirth D, Sabeti PC, Rinn JL. A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biology. 12: R56. PMID 21689454 DOI: 10.1186/Gb-2011-12-6-R56  0.634
2011 Van Tyne D, Park DJ, Schaffner SF, Neafsey DE, Angelino E, Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA, Johnson CA, Shlyakhter I, Grossman SR, Becker JS, ... ... Wirth DF, et al. Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. Plos Genetics. 7: e1001383. PMID 21533027 DOI: 10.1371/Journal.Pgen.1001383  0.837
2011 Buchholz K, Burke TA, Williamson KC, Wiegand RC, Wirth DF, Marti M. A high-throughput screen targeting malaria transmission stages opens new avenues for drug development. The Journal of Infectious Diseases. 203: 1445-53. PMID 21502082 DOI: 10.1093/Infdis/Jir037  0.47
2011 Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, ... ... Wirth DF, et al. Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 55: 2612-22. PMID 21422215 DOI: 10.1128/Aac.01714-10  0.302
2011 Amino R, Bassat Q, Baum J, Billker O, Bogyo M, Bousema T, Christophides G, Deitsch K, Dinglasan R, Djimde A, Duraisingh M, Dzinjalamala F, Happi C, Heussler V, Kramarik J, ... ... Wirth D, et al. A research agenda for malaria eradication: basic science and enabling technologies Plos Medicine. 8: 1-6. PMID 21311584 DOI: 10.1371/Journal.Pmed.1000399  0.419
2011 Alonso P, Bassat Q, Binka F, Brewer T, Chandra R, Culpepper J, Dinglasan R, Duncan K, Duparc S, Fukuda M, Laxminarayan R, MacArthur, Magill A, Marzetta C, Milman J, ... ... Wirth D, et al. A research agenda for malaria eradication: drugs. Plos Medicine. PMID 21311580 DOI: 10.1371/Journal.Pmed.1000402  0.444
2010 Neafsey DE, Lawniczak MK, Park DJ, Redmond SN, Coulibaly MB, Traoré SF, Sagnon N, Costantini C, Johnson C, Wiegand RC, Collins FH, Lander ES, Wirth DF, Kafatos FC, Besansky NJ, et al. SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes. Science (New York, N.Y.). 330: 514-7. PMID 20966254 DOI: 10.1126/Science.1193036  0.387
2010 Booker ML, Bastos CM, Kramer ML, Barker RH, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, ... ... Wirth DF, et al. Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. The Journal of Biological Chemistry. 285: 33054-64. PMID 20702404 DOI: 10.1074/Jbc.M110.162081  0.372
2010 Orjuela-Sánchez P, Karunaweera ND, da Silva-Nunes M, da Silva NS, Scopel KK, Gonçalves RM, Amaratunga C, Sá JM, Socheat D, Fairhust RM, Gunawardena S, Thavakodirasah T, Galapaththy GL, Abeysinghe R, Kawamoto F, ... Wirth DF, et al. Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies. Bmc Genetics. 11: 65. PMID 20626846 DOI: 10.1186/1471-2156-11-65  0.485
2010 Zilversmit MM, Volkman SK, DePristo MA, Wirth DF, Awadalla P, Hartl DL. Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome. Molecular Biology and Evolution. 27: 2198-209. PMID 20427419 DOI: 10.1093/Molbev/Msq108  0.426
2010 Gunawardena S, Karunaweera ND, Ferreira MU, Phone-Kyaw M, Pollack RJ, Alifrangis M, Rajakaruna RS, Konradsen F, Amerasinghe PH, Schousboe ML, Galappaththy GN, Abeyasinghe RR, Hartl DL, Wirth DF. Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. The American Journal of Tropical Medicine and Hygiene. 82: 235-42. PMID 20133999 DOI: 10.4269/Ajtmh.2010.09-0588  0.391
2010 Ndiaye D, Patel V, Demas A, LeRoux M, Ndir O, Mboup S, Clardy J, Lakshmanan V, Daily JP, Wirth DF. A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal. The American Journal of Tropical Medicine and Hygiene. 82: 228-30. PMID 20133997 DOI: 10.4269/Ajtmh.2010.09-0470  0.477
2010 Wirth DF, Barker RH. Response: malaria diagnosis. Science (New York, N.Y.). 236: 12. PMID 17759192 DOI: 10.1126/Science.236.4797.12  0.318
2009 Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. Journal of Medicinal Chemistry. 52: 2185-7. PMID 19317450 DOI: 10.1021/Jm801654Y  0.351
2009 Rush MA, Baniecki ML, Mazitschek R, Cortese JF, Wiegand R, Clardy J, Wirth DF. Colorimetric high-throughput screen for detection of heme crystallization inhibitors. Antimicrobial Agents and Chemotherapy. 53: 2564-8. PMID 19307367 DOI: 10.1128/Aac.01466-08  0.405
2009 Dharia NV, Sidhu AB, Cassera MB, Westenberger SJ, Bopp SE, Eastman RT, Plouffe D, Batalov S, Park DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler EA. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biology. 10: R21. PMID 19216790 DOI: 10.1186/Gb-2009-10-2-R21  0.465
2009 Sims JS, Militello KT, Sims PA, Patel VP, Kasper JM, Wirth DF. Patterns of gene-specific and total transcriptional activity during the Plasmodium falciparum intraerythrocytic developmental cycle. Eukaryotic Cell. 8: 327-38. PMID 19151330 DOI: 10.1128/Ec.00340-08  0.357
2009 Lantos PM, Ahouidi AD, Bei AK, Jennings CV, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT. Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum. Parasitology. 136: 1-9. PMID 19126266 DOI: 10.1017/S0031182008005167  0.406
2009 Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF. Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 972-5. PMID 19097788 DOI: 10.1016/J.Bmcl.2008.11.071  0.718
2009 Happi CT, Gbotosho GO, Folarin OA, Sowunmi A, Hudson T, O'Neil M, Miihous W, Wirth DF, Oduola AMJ. Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in nigerian children with uncomplicated falciparum malaria Antimicrobial Agents and Chemotherapy. 53: 888-895. PMID 19075074 DOI: 10.1128/Aac.00968-08  0.431
2009 Nunes JK, Starnbach MN, Wirth DF. Secreted antibody is required for immunity to Plasmodium berghei. Infection and Immunity. 77: 414-8. PMID 19001073 DOI: 10.1128/Iai.00982-08  0.302
2008 Neafsey DE, Schaffner SF, Volkman SK, Park D, Montgomery P, Milner DA, Lukens A, Rosen D, Daniels R, Houde N, Cortese JF, Tyndall E, Gates C, Stange-Thomann N, Sarr O, ... ... Wirth DF, et al. Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biology. 9: R171. PMID 19077304 DOI: 10.1186/Gb-2008-9-12-R171  0.789
2008 Daniels R, Volkman SK, Milner DA, Mahesh N, Neafsey DE, Park DJ, Rosen D, Angelino E, Sabeti PC, Wirth DF, Wiegand RC. A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking. Malaria Journal. 7: 223. PMID 18959790 DOI: 10.1186/1475-2875-7-223  0.683
2008 Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. The Journal of Biological Chemistry. 283: 35078-85. PMID 18842591 DOI: 10.1074/Jbc.M804990200  0.685
2008 Sarr O, Ahouidi AD, Ly O, Daily JP, Ndiaye D, Ndir O, Mboup S, Wirth DF. Mutations in PFCRT K76T do not correlate with sulfadoxine-pyrimethamine-amodiaquine failure in Pikine, Senegal. Parasitology Research. 103: 765-9. PMID 18523801 DOI: 10.1007/S00436-008-1038-9  0.318
2008 Karunaweera ND, Ferreira MU, Munasinghe A, Barnwell JW, Collins WE, King CL, Kawamoto F, Hartl DL, Wirth DF. Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax. Gene. 410: 105-12. PMID 18226474 DOI: 10.1016/J.Gene.2007.11.022  0.814
2008 Mbacham WF, Mimche PN, Netongo PM, Marie-Solange EB, Nji A, Amunom I, Daily J, Makoge V, Laserson K, Yong SM, Lomah N, Enyong P, Titanji VP, Wirth DF. Limited variation of the 5′cis-control region of the transmission blocking vaccine candidate Pfs25 amid great genetic diversity of Plasmodium falciparum in Cameroon African Journal of Biotechnology. 7: 523-533.  0.345
2007 Daily JP, Scanfeld D, Pochet N, Le Roch K, Plouffe D, Kamal M, Sarr O, Mboup S, Ndir O, Wypij D, Levasseur K, Thomas E, Tamayo P, Dong C, Zhou Y, ... ... Wirth D, et al. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature. 450: 1091-5. PMID 18046333 DOI: 10.1038/Nature06311  0.77
2007 Bethke L, Thomas S, Walker K, Lakhia R, Rangarajan R, Wirth D. The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites. Molecular and Biochemical Parasitology. 155: 18-25. PMID 17583362 DOI: 10.1016/J.Molbiopara.2007.05.003  0.829
2007 Gunasekera AM, Myrick A, Le Roch K, Winzeler E, Wirth DF. Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. Experimental Parasitology. 117: 87-92. PMID 17475254 DOI: 10.1016/J.Exppara.2007.03.001  0.793
2007 Jennings CV, Ahouidi AD, Zilversmit M, Bei AK, Rayner J, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT. Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal Infection and Immunity. 75: 3531-3538. PMID 17470537 DOI: 10.1128/Iai.00122-07  0.449
2007 Ferreira MU, Karunaweera ND, da Silva-Nunes M, da Silva NS, Wirth DF, Hartl DL. Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia. The Journal of Infectious Diseases. 195: 1218-26. PMID 17357061 DOI: 10.1086/512685  0.419
2007 Gunasekera AM, Myrick A, Militello KT, Sims JS, Dong CK, Gierahn T, Le Roch K, Winzeler E, Wirth DF. Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum. Molecular and Biochemical Parasitology. 153: 19-30. PMID 17307259 DOI: 10.1016/J.Molbiopara.2007.01.011  0.803
2007 Gunasekera AM, Wickramarachchi T, Neafsey DE, Ganguli I, Perera L, Premaratne PH, Hartl D, Handunnetti SM, Udagama-Randeniya PV, Wirth DF. Genetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population. Molecular Biology and Evolution. 24: 939-47. PMID 17244598 DOI: 10.1093/Molbev/Msm013  0.358
2007 Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, ... ... Wirth DF, et al. A genome-wide map of diversity in Plasmodium falciparum. Nature Genetics. 39: 113-9. PMID 17159979 DOI: 10.1038/Ng1930  0.778
2007 Baniecki ML, Wirth DF, Clardy J. High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrobial Agents and Chemotherapy. 51: 716-23. PMID 17116676 DOI: 10.1128/Aac.01144-06  0.446
2007 Volkman SK, Lozovsky E, Barry AE, Bedford T, Bethke L, Myrick A, Day KP, Hartl DL, Wirth DF, Sawyer SA. Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum. Gene. 387: 1-6. PMID 17005334 DOI: 10.1016/J.Gene.2006.07.026  0.777
2007 Karunaweera ND, Ferreira MU, Hartl DL, Wirth DF. Fourteen polymorphic microsatellite DNA markers for the human malaria parasite Plasmodium vivax Molecular Ecology Notes. 7: 172-175. DOI: 10.1111/J.1471-8286.2006.01534.X  0.448
2006 Happi CT, Gbotosho GO, Folarin OA, Milner D, Sarr O, Sowunmi A, Kyle DE, Milhous WK, Wirth DF, Oduola AM. Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa. Malaria Journal. 5: 82. PMID 17020611 DOI: 10.1186/1475-2875-5-82  0.431
2006 Ndiaye D, Daily JP, Sarr O, Ndir O, Gaye O, Mboup S, Roper C, Wirth DF. Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal Acta Tropica. 99: 106-111. PMID 16905111 DOI: 10.1016/J.Actatropica.2006.07.002  0.343
2006 Happi CT, Gbotosho GO, Folarin OA, Sowunmi A, Bolaji OM, Fateye BA, Kyle DE, Milhous W, Wirth DF, Oduola AMJ. Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria Parasitology Research. 100: 141-148. PMID 16874478 DOI: 10.1007/S00436-006-0246-4  0.422
2006 Bethke LL, Zilversmit M, Nielsen K, Daily J, Volkman SK, Ndiaye D, Lozovsky ER, Hartl DL, Wirth DF. Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum. Molecular and Biochemical Parasitology. 150: 10-24. PMID 16860410 DOI: 10.1016/J.Molbiopara.2006.06.004  0.787
2006 Happi CT, Gbotosho GO, Folarin OA, Bolaji OM, Sowunmi A, Kyle DE, Milhous W, Wirth DF, Oduola AMJ. Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria American Journal of Tropical Medicine and Hygiene. 75: 155-161. PMID 16837724 DOI: 10.4269/Ajtmh.2006.75.155  0.488
2006 Kidgell C, Volkman SK, Daily J, Borevitz JO, Plouffe D, Zhou Y, Johnson JR, Le Roch K, Sarr O, Ndir O, Mboup S, Batalov S, Wirth DF, Winzeler EA. A systematic map of genetic variation in Plasmodium falciparum. Plos Pathogens. 2: e57. PMID 16789840 DOI: 10.1371/Journal.Ppat.0020057  0.504
2006 Kidgell C, Volkman SK, Daily J, Borevitz JO, Plouffe D, Zhou Y, Johnson JR, Roch KGL, Sarr O, Ndir O, Mboup S, Batalov S, Wirth DF, Winzeler EA. Correction: A Systematic Map of Genetic Variation in Plasmodium falciparum Plos Pathogens. 2: e96. DOI: 10.1371/Journal.Ppat.0020096  0.352
2005 Ndiaye D, Daily JP, Sarr O, Ndir O, Gaye O, Mboup S, Wirth DF. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Senegal Tropical Medicine and International Health. 10: 1176-1179. PMID 16262743 DOI: 10.1111/J.1365-3156.2005.01506.X  0.391
2005 Jethwaney D, Lepore T, Hassan S, Mello K, Rangarajan R, Jahnen-Dechent W, Wirth D, Sultan AA. Fetuin-A, a hepatocyte-specific protein that binds Plasmodium berghei thrombospondin-related adhesive protein: a potential role in infectivity. Infection and Immunity. 73: 5883-91. PMID 16113307 DOI: 10.1128/Iai.73.9.5883-5891.2005  0.33
2005 Happi CT, Gbotosho GO, Folarin OA, Akinboye DO, Yusuf BO, Ebong OO, Sowunmi A, Kyle DE, Milhous W, Wirth DF, Oduola AMJ. Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria Acta Tropica. 95: 183-193. PMID 16023986 DOI: 10.1016/J.Actatropica.2005.06.015  0.381
2005 Sarr O, Myrick A, Daily J, Diop BM, Dieng T, Ndir O, Sow PS, Mboup S, Wirth DF. In vivo and in vitro analysis of chloroquine resistance in Plasmodium falciparum isolates from Senegal. Parasitology Research. 97: 136-40. PMID 15986248 DOI: 10.1007/S00436-005-1406-7  0.779
2005 Daily JP, Le Roch KG, Sarr O, Ndiaye D, Lukens A, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler EA, Wirth DF. In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. The Journal of Infectious Diseases. 191: 1196-203. PMID 15747257 DOI: 10.1086/428289  0.748
2005 Myrick A, Sarr O, Dieng T, Ndir O, Mboup S, Wirth DF. Analysis of the genetic diversity of the Plasmodium falciparum multidrug resistance gene 5' upstream region. The American Journal of Tropical Medicine and Hygiene. 72: 182-8. PMID 15741555 DOI: 10.4269/Ajtmh.2005.72.182  0.805
2004 Emerson LR, Skillman BC, Wolfger H, Kuchler K, Wirth DF. The sensitivities of yeast strains deficient in PDR ABC transporters, to quinoline-ring antimalarial drugs. Annals of Tropical Medicine and Parasitology. 98: 643-9. PMID 15324472 DOI: 10.1179/000349804225021523  0.801
2004 Daily JP, Le Roch KG, Sarr O, Fang X, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler EA, Wirth DF. In vivo transcriptional profiling of Plasmodium falciparum. Malaria Journal. 3: 30. PMID 15296511 DOI: 10.1186/1475-2875-3-30  0.413
2004 Gunasekera AM, Patankar S, Schug J, Eisen G, Kissinger J, Roos D, Wirth DF. Widespread distribution of antisense transcripts in the Plasmodium falciparum genome. Molecular and Biochemical Parasitology. 136: 35-42. PMID 15138065 DOI: 10.1016/J.Molbiopara.2004.02.007  0.38
2004 Dodge MA, Waller RF, Chow LM, Zaman MM, Cotton LM, McConville MJ, Wirth DF. Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites. Molecular Microbiology. 51: 1563-75. PMID 15009885 DOI: 10.1111/J.1365-2958.2003.03927.X  0.388
2004 Happi CT, Gbotosho GO, Sowunmi A, Falade CO, Akinboye DO, Gerena L, Kyle DE, Milhous W, Wirth DF, Oduola AMJ. Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria American Journal of Tropical Medicine and Hygiene. 70: 20-26. PMID 14971693 DOI: 10.4269/Ajtmh.2004.70.20  0.414
2004 Militello KT, Dodge M, Bethke L, Wirth DF. Identification of regulatory elements in the Plasmodium falciparum genome. Molecular and Biochemical Parasitology. 134: 75-88. PMID 14747145 DOI: 10.1016/J.Molbiopara.2003.11.004  0.79
2003 Happi TC, Thomas SM, Gbotosho GO, Falade CO, Akinboye DO, Gerena L, Hudson T, Sowunmi A, Kyle DE, Milhous W, Wirth DF, Oduola AMJ. Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria Annals of Tropical Medicine and Parasitology. 97: 439-451. PMID 12930607 DOI: 10.1179/000349803235002489  0.419
2003 Myrick A, Munasinghe A, Patankar S, Wirth DF. Mapping of the Plasmodium falciparum multidrug resistance gene 5'-upstream region, and evidence of induction of transcript levels by antimalarial drugs in chloroquine sensitive parasites. Molecular Microbiology. 49: 671-83. PMID 12864851 DOI: 10.1046/J.1365-2958.2003.03597.X  0.817
2003 Chow CS, Wirth DF. Linker scanning mutagenesis of the Plasmodium gallinaceum sexual stage specific gene pgs28 reveals a novel downstream cis-control element. Molecular and Biochemical Parasitology. 129: 199-208. PMID 12850264 DOI: 10.1016/S0166-6851(03)00101-4  0.375
2003 Daily JP, Roberts C, Thomas SM, Ndir O, Dieng T, Mboup S, Wirth DF. Prevalence of Plasmodium falciparum pfcrt polymorphisms and in vitro chloroquine sensitivity in Senegal Parasitology. 126: 401-405. PMID 12793643 DOI: 10.1017/S0031182003002981  0.369
2003 Nielsen KM, Kasper J, Choi M, Bedford T, Kristiansen K, Wirth DF, Volkman SK, Lozovsky ER, Hartl DL. Gene conversion as a source of nucleotide diversity in Plasmodium falciparum. Molecular Biology and Evolution. 20: 726-34. PMID 12679555 DOI: 10.1093/Molbev/Msg076  0.323
2003 Militello KT, Wirth DF. A new reporter gene for transient transfection of Plasmodium falciparum. Parasitology Research. 89: 154-7. PMID 12489017 DOI: 10.1007/S00436-002-0721-5  0.334
2003 Chow CS, Wirth DF. Corrigendum to “Linker scanning mutagenesis of the Plasmodium gallinaceum sexual stage specific gene pgs28 reveals a novel downstream cis-control element” Molecular and Biochemical Parasitology. 132: 105. DOI: 10.1016/J.Molbiopara.2003.08.008  0.301
2002 Wirth DF. Biological revelations. Nature. 419: 495-6. PMID 12368862 DOI: 10.1038/419495A  0.43
2002 Volkman SK, Hartl DL, Wirth DF, Nielsen KM, Choi M, Batalov S, Zhou Y, Plouffe D, Le Roch KG, Abagyan R, Winzeler EA. Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science (New York, N.Y.). 298: 216-8. PMID 12364807 DOI: 10.1126/Science.1075642  0.346
2002 Thomas SM, Ndir O, Dieng T, Mboup S, Wypij D, Maguire JH, Wirth DF. In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal. The American Journal of Tropical Medicine and Hygiene. 66: 474-80. PMID 12201579 DOI: 10.4269/Ajtmh.2002.66.474  0.42
2002 Hartl DL, Volkman SK, Nielsen KM, Barry AE, Day KP, Wirth DF, Winzeler EA. The paradoxical population genetics of Plasmodium falciparum. Trends in Parasitology. 18: 266-72. PMID 12036741 DOI: 10.1016/S1471-4922(02)02268-7  0.404
2002 Emerson LR, Nau ME, Martin RK, Kyle DE, Vahey M, Wirth DF. Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae. Antimicrobial Agents and Chemotherapy. 46: 787-96. PMID 11850263 DOI: 10.1128/Aac.46.3.787-796.2002  0.778
2001 Trouiller P, Torreele E, Olliaro P, White N, Foster S, Wirth D, Pécoul B. Drugs for neglected diseases: a failure of the market and a public health failure? Tropical Medicine & International Health. 6: 945-951. PMID 11703850 DOI: 10.1046/J.1365-3156.2001.00803.X  0.308
2001 Patankar S, Munasinghe A, Shoaibi A, Cummings LM, Wirth DF. Serial analysis of gene expression in Plasmodium falciparum reveals the global expression profile of erythrocytic stages and the presence of anti-sense transcripts in the malarial parasite Molecular Biology of the Cell. 12: 3114-3125. PMID 11598196 DOI: 10.1091/Mbc.12.10.3114  0.806
2001 Volkman SK, Barry AE, Lyons EJ, Nielsen KM, Thomas SM, Choi M, Thakore SS, Day KP, Wirth DF, Hartl DL. Recent origin of Plasmodium falciparum from a single progenitor. Science (New York, N.Y.). 293: 482-4. PMID 11463913 DOI: 10.1126/Science.1059878  0.478
2001 Mbacham WF, Chow CS, Daily J, Golightly LM, Wirth DF. Deletion analysis of the 5′ flanking sequence of the Plasmodium gallinaceum sexual stage specific gene pgs28 suggests a bipartite arrangement of cis-control elements Molecular and Biochemical Parasitology. 113: 183-187. PMID 11254967 DOI: 10.1016/S0166-6851(01)00210-9  0.304
2001 Munasinghe A, Patankar S, Cook BP, Madden SL, Martin RK, Kyle DE, Shoaibi A, Cummings LM, Wirth DF. Serial analysis of gene expression (SAGE) in Plasmodium falciparum: application of the technique to A-T rich genomes. Molecular and Biochemical Parasitology. 113: 23-34. PMID 11254951 DOI: 10.1016/S0166-6851(00)00378-9  0.808
2000 Vasconcelos KF, Plowe CV, Fontes CJ, Kyle D, Wirth DF, Pereira Da Silva LH, Zalis MG. Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropteroate Synthase of Isolates from the Amazon Region of Brazil Memorias Do Instituto Oswaldo Cruz. 95: 721-728. PMID 10998224 DOI: 10.1590/S0074-02762000000500020  0.361
2000 Hauser H, Spitzer D, Verhoeyen E, Unsinger J, Wirth D. New approaches towards ex vivo and in vivo gene therapy. Cells, Tissues, Organs. 167: 75-80. PMID 10971031 DOI: 10.1159/000016770  0.325
2000 Nau ME, Emerson LR, Martin RK, Kyle DE, Wirth DF, Vahey M. Technical assessment of the affymetrix yeast expression GeneChip YE6100 platform in a heterologous model of genes that confer resistance to antimalarial drugs in yeast. Journal of Clinical Microbiology. 38: 1901-8. PMID 10790119 DOI: 10.1128/Jcm.38.5.1901-1908.2000  0.802
2000 Golightly LM, Mbacham W, Daily J, Wirth DF. 3' UTR elements enhance expression of Pgs28, an ookinete protein of Plasmodium gallinaceum Molecular and Biochemical Parasitology. 105: 61-70. PMID 10613699 DOI: 10.1016/S0166-6851(99)00165-6  0.396
1999 Laserson KF, Petralanda I, Almera R, Barker RH, Spielman A, Maguire JH, Wirth DF. Genetic characterization of an epidemic of Plasmodium falciparum malaria among Yanomami Amerindians Journal of Infectious Diseases. 180: 2081-2085. PMID 10558976 DOI: 10.1086/315144  0.442
1999 Dechering KJ, Kaan AM, Mbacham W, Wirth DF, Eling W, Konings RNH, Stunnenberg HG. Isolation and functional characterization of two distinct sexual-stage- specific promoters of the human malaria parasite Plasmodium falciparum Molecular and Cellular Biology. 19: 967-978. PMID 9891033 DOI: 10.1128/Mcb.19.2.967  0.387
1999 Wirth DF. Chapter 33. Malaria: A Third World Disease in Need of First World Drug Development Annual Reports in Medicinal Chemistry. 34: 349-358. DOI: 10.1016/S0065-7743(08)60595-3  0.427
1998 Wirth D. Malaria: A 21st century solution for an ancient disease Nature Medicine. 4: 1360-1362. PMID 9846567 DOI: 10.1038/3943  0.408
1998 Volkman S, Wirth D. Functional analysis of pfmdr1 gene of Plasmodium falciparum. Methods in Enzymology. 292: 174-81. PMID 9711553 DOI: 10.1016/S0076-6879(98)92014-6  0.45
1998 Zalis MG, Pang L, Silveira MS, Milhous WK, Wirth DF. Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: Evidence for quinine resistance American Journal of Tropical Medicine and Hygiene. 58: 630-637. PMID 9598453 DOI: 10.4269/Ajtmh.1998.58.630  0.455
1998 Saiz M, Llanos-Cuentas A, Echevarria J, Roncal N, Cruz M, Muniz MT, Lucas C, Wirth DF, Scheffter S, Magill AJ, Patterson JL. Short report: detection of Leishmaniavirus in human biopsy samples of leishmaniasis from Peru. The American Journal of Tropical Medicine and Hygiene. 58: 192-4. PMID 9502603 DOI: 10.4269/Ajtmh.1998.58.192  0.32
1996 Gueiros-Filho FJ, Viola JP, Gomes FC, Farina M, Lins U, Bertho AL, Wirth DF, Lopes UG. Leishmania amazonensis: multidrug resistance in vinblastine-resistant promastigotes is associated with rhodamine 123 efflux, DNA amplification, and RNA overexpression of a Leishmania mdr1 gene. Experimental Parasitology. 81: 480-90. PMID 8542989 DOI: 10.1006/Expr.1995.1141  0.374
1996 Waters AF, Wirth DF, Wellems TE, Del Portllo HA. Transfection of malaria parasites Parasitology Today. 12: 129-132. DOI: 10.1016/0169-4758(96)30002-1  0.439
1996 Olliaro P, Cattani J, Wirth D. Malaria, the submerged disease. Jama. 275: 230-233. DOI: 10.1001/Jama.1996.03530270070034  0.393
1995 Volkman SK, Cowman AF, Wirth DF. Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum Proceedings of the National Academy of Sciences of the United States of America. 92: 8921-8925. PMID 7568044 DOI: 10.1073/Pnas.92.19.8921  0.428
1994 Barker RH, Banchongaksorn T, Courvau JM, Suwonkerd W, Rimwungtragoon K, Srittong N, Wirth DF. DNA probes as epidemiological tools for surveillance of plasmodium falciparum malaria in Thailand International Journal of Epidemiology. 23: 161-168. PMID 8194913 DOI: 10.1093/Ije/23.1.161  0.302
1994 Coutaux AF, Mooney JJ, Wirth DF. Neuronal monoamine reuptake inhibitors enhance in vitro susceptibility to chloroquine in resistant Plasmodium falciparum Antimicrobial Agents and Chemotherapy. 38: 1419-1421. PMID 8092848 DOI: 10.1128/Aac.38.6.1419  0.36
1994 Wong AKC, Chow LMC, Wirth DF. A homologous recombination strategy to analyze the vinblastine resistance property of the V-circle in Leishmania Molecular and Biochemical Parasitology. 64: 75-86. PMID 8078525 DOI: 10.1016/0166-6851(94)90136-8  0.407
1994 Barker RH, Banchongaksorn T, Courval JM, Suwonkerd W, Rimwungtragoon K, Wirth DF. Plasmodium falciparum and P. vivax: Factors affecting sensitivity and specificity of PCR-based diagnosis of malaria Experimental Parasitology. 79: 41-49. PMID 8050524 DOI: 10.1006/Expr.1994.1057  0.327
1994 Zalis MG, Wilson CM, Zhang Y, Wirth DF. Characterization of the pfmdr2 gene for Plasmodium falciparum Molecular and Biochemical Parasitology. 63: 311. PMID 7911976 DOI: 10.1016/0166-6851(94)90068-X  0.416
1993 Goonewardene R, Daily J, Kaslow D, Sullivan TJ, Duffy P, Carter R, Mendis K, Wirth D. Transfection of the malaria parasite and expression of firefly luciferase. Proceedings of the National Academy of Sciences of the United States of America. 90: 5234-6. PMID 8506371 DOI: 10.1073/Pnas.90.11.5234  0.422
1993 Acuna-Soto R, Samuelson J, De Girolami P, Zarate L, Millan-Velasco F, Schoolnick G, Wirth D. Application of the polymerase chain reaction to the epidemiology of pathogenic and nonpathogenic Entamoeba histolytica. The American Journal of Tropical Medicine and Hygiene. 48: 58-70. PMID 8427389 DOI: 10.4269/Ajtmh.1993.48.58  0.311
1993 Wilson CM, Volkman SK, Thaithong S, Martin RK, Kyle DE, Milhous WK, Wirth DF. Amplification of pfmdr1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand Molecular and Biochemical Parasitology. 57: 151-160. PMID 8426608 DOI: 10.1016/0166-6851(93)90252-S  0.441
1993 Chow LMC, Wong AKC, Ullman B, Wirth DF. Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enriettii Molecular and Biochemical Parasitology. 60: 195-208. PMID 8232412 DOI: 10.1016/0166-6851(93)90131-G  0.437
1993 Zalis MG, Wilson CM, Zhang Y, Wirth DF. Characterization of the pfmdr 2 gene for Plasmodium falciparum Molecular and Biochemical Parasitology. 62: 83-92. PMID 8114829 DOI: 10.1016/0166-6851(93)90180-6  0.301
1993 Hendrickson N, Sifri CD, Henderson DM, Allen T, Wirth DF, Ullman B. Molecular characterization of the ldmdr1 multidrug resistance gene from Leishmania donovani. Molecular and Biochemical Parasitology. 60: 53-64. PMID 8103567 DOI: 10.1016/0166-6851(93)90028-V  0.393
1993 Volkman SK, Wilson CM, Wirth DF. Stage-specific transcripts of the Plasmodium falciparum pfmdr1 gene Molecular and Biochemical Parasitology. 57: 203-211. PMID 8094538 DOI: 10.1016/0166-6851(93)90196-5  0.422
1992 Barker RH, Banchongaksorn T, Courval JM, Suwonkerd W, Rimwungtragoon K, Wirth DF. A simple method to detect Plasmodium falciparum directly from blood samples using the polymerase chain reaction American Journal of Tropical Medicine and Hygiene. 46: 416-426. PMID 1575288 DOI: 10.4269/Ajtmh.1992.46.416  0.319
1992 De Curotto Lafaille MA, Laban A, Wirth DF. Gene expression in Leishmania: Analysis of essential 5′ DNA sequences Proceedings of the National Academy of Sciences of the United States of America. 89: 2703-2707. PMID 1557376 DOI: 10.1073/Pnas.89.7.2703  0.349
1992 Henderson DM, Sifri CD, Rodgers M, Wirth DF, Hendrickson N, Ullman B. Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene. Molecular and Cellular Biology. 12: 2855-65. PMID 1350325 DOI: 10.1128/Mcb.12.6.2855  0.455
1991 Laskay T, Kiessling R, Rinke DeWit TF, Wirth DF. Generation of species-specific DNA probes for Leishmania aethiopica Molecular and Biochemical Parasitology. 44: 279-286. PMID 2052028 DOI: 10.1016/0166-6851(91)90014-W  0.303
1991 Tobin JF, Laban A, Wirth DF. Homologous recombination in Leishmania enriettii Proceedings of the National Academy of Sciences of the United States of America. 88: 864-868. PMID 1992478 DOI: 10.1073/Pnas.88.3.864  0.399
1990 Ayala P, Samuelson J, Wirth D, Orozco E. Entamoeba histolytica: Physiology of multidrug resistance Experimental Parasitology. 71: 169-175. PMID 2373187 DOI: 10.1016/0014-4894(90)90019-9  0.372
1990 Laban A, Tobin JF, De Lafaille MAC, Wirth DF. Stable expression of the bacterial neor gene in Leishmania enriettii Nature. 343: 572-574. PMID 2300209 DOI: 10.1038/343572A0  0.377
1990 Samuelson J, Ayala P, Orozco E, Wirth D. Emetine-resistant mutants of Entamoeba histolytica overexpress mRNAs for multidrug resistance Molecular and Biochemical Parasitology. 38: 281-290. PMID 1970121 DOI: 10.1016/0166-6851(90)90031-G  0.429
1989 Joseph JT, Aldritt SM, Unnasch T, Puijalon O, Wirth DF. Characterization of a conserved extrachromosomal element isolated from the avian malarial parasite Plasmodium gallinaceum. Molecular and Cellular Biology. 9: 3621-9. PMID 2779561 DOI: 10.1128/Mcb.9.9.3621  0.372
1989 Aldritt SM, Joseph JT, Wirth DF. Sequence identification of cytochrome b in Plasmodium gallinaceum. Molecular and Cellular Biology. 9: 3614-20. PMID 2779560 DOI: 10.1128/Mcb.9.9.3614  0.368
1989 Wirth DF, Rogers WO, Barker R, Dourado H, Suesebang L, Albuquerque B. Leishmaniasis and malaria: DNA probes for diagnosis and epidemiologic analysis Annals of the New York Academy of Sciences. 569: 183-192. PMID 2698086 DOI: 10.1111/J.1749-6632.1989.Tb27368.X  0.308
1989 Bakker RH, Suebsaeng L, Rooney W, Wirth DF. Detection of Plasmodium falciparum infection in human patients: A comparison of the DNA probe method to microscopic diagnosis American Journal of Tropical Medicine and Hygiene. 41: 266-272. PMID 2679157 DOI: 10.4269/Ajtmh.1989.41.266  0.337
1989 Barker RH, Brandling-Bennett AD, Koech DK, Mugambi M, Khan B, David R, David JR, Wirth DF. Plasmodium falciparum: DNA probe diagnosis of malaria in Kenya Experimental Parasitology. 69: 226-233. PMID 2676577 DOI: 10.1016/0014-4894(89)90069-6  0.32
1989 Wilson CM, Serrano AE, Wasley A, Bogenschutz MP, Shankar AH, Wirth DF. Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum Science. 244: 1184-1186. PMID 2658061 DOI: 10.1126/Science.2658061  0.468
1989 Laban A, Wirth DF. Transfection of Leishmania enriettii and expression of chloramphenicol acetyltransferase gene Proceedings of the National Academy of Sciences of the United States of America. 86: 9119-9123. PMID 2594753 DOI: 10.1073/Pnas.86.23.9119  0.313
1989 Samuelson J, Acuna-Soto R, Reed S, Biagi F, Wirth D. DNA hybridization probe for clinical diagnosis of Entamoeba histolytica. Journal of Clinical Microbiology. 27: 671-676. PMID 2542361 DOI: 10.1128/Jcm.27.4.671-676.1989  0.331
1987 Sim BK, Shah J, Wirth DF, Piessens WF. Characterization of the filarial genome Ciba Foundation Symposium. 127: 107-124. PMID 2885158  0.32
1986 Wirth DF, Rogers WO, Barker R, Dourado H, Suesebang L, Albuquerque B. Leishmaniasis and malaria: New tools for epidemiologic analysis Science. 234: 975-979. PMID 3535070 DOI: 10.1126/Science.3535070  0.409
1986 Sim KL, Mak JW, Cheong WH, Sutanto I, Kurniawan L, Marwoto HA, Franke E, Campell JR, Wirth DF, Piessens WF. Identification of Brugia malayi in vectors with a species-specific DNA probe American Journal of Tropical Medicine and Hygiene. 35: 559-564. PMID 3518507 DOI: 10.4269/Ajtmh.1986.35.559  0.302
1986 Barker RH, Suebsaeng L, Rooney W, Alecrim GC, Dourado HV, Wirth DF. Specific DNA probe for the diagnosis of Plasmodium falciparum malaria Science. 231: 1434-1436. PMID 3513309 DOI: 10.1126/Science.3513309  0.402
1986 Lopes UG, Wirth DF. Identification of visceral Leishmania species with cloned sequences of kinetoplast DNA Molecular and Biochemical Parasitology. 20: 77-84. PMID 3016536 DOI: 10.1016/0166-6851(86)90144-1  0.301
1986 Shah JS, Lamontagne L, Unnasch TR, Wirth DF, Piessens WF. Characterization of a ribosomal DNA clone of Brugia malayi. Molecular and Biochemical Parasitology. 19: 67-75. PMID 3012333 DOI: 10.1016/0166-6851(86)90067-8  0.301
1986 Miller SI, Landfear SM, Wirth DF. Cloning and characterization of a leishmania gene encoding a RNA spliced leader sequence Nucleic Acids Research. 14: 7341-7360. PMID 2429261 DOI: 10.1093/Nar/14.18.7341  0.335
1986 Wirth DF, Barker Junior R, Alecrim G, Dourado H, Suesebang L, Albuquerque B. Malaria: new tools for epidemiological analysis MemóRias Do Instituto Oswaldo Cruz. 81: 231-234. DOI: 10.1590/S0074-02761986000600038  0.359
1985 Unnasch TR, McLafferty M, Wirth DF. The primary structure of the rRNA insertions of Plasmodium lophurae Molecular and Biochemical Parasitology. 16: 149-161. PMID 2993883 DOI: 10.1016/0166-6851(85)90083-0  0.33
1984 Landfear SM, Wirth DF. Control of tubulin gene expression in the parasitic protozoan Leishmania enriettii Nature. 309: 716-717. PMID 6728033 DOI: 10.1038/309716A0  0.364
1984 Carter R, Miller LH, Rener J, Kaushal DC, Kumar N, Graves PM, Grotendorst CA, Gwadz RW, French C, Wirth D. Target antigens in malaria transmission blocking immunity Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 307: 201-213. PMID 6151684 DOI: 10.1098/Rstb.1984.0120  0.388
1983 Landfear SM, McMahon Pratt D, Wirth DF. Tandem arrangement of tubulin genes in the protozoan parasite Leishmania enriettii Molecular and Cellular Biology. 3: 1070-1076. PMID 6877238 DOI: 10.1128/mcb.3.6.1070-1076.1983  0.311
1983 Unnasch TR, Wirth DF. The cloned rRNA genes of P. lophurae: A novel rDNA structure Nucleic Acids Research. 11: 8461-8472. PMID 6324085 DOI: 10.1093/Nar/11.23.8461  0.307
1983 Unnasch TR, Wirth DF. The avian malaria Plasmodium lophurae has a small number of heterogeneous ribosomal RNA genes Nucleic Acids Research. 11: 8443-8459. PMID 6324084 DOI: 10.1093/Nar/11.23.8443  0.425
1983 Wirth DF, Slater C. Isolation and characterization of an α-tubulin gene from Leishmania enriettii Molecular and Biochemical Parasitology. 9: 83-92. PMID 6321982 DOI: 10.1016/0166-6851(83)90059-2  0.314
Low-probability matches (unlikely to be authored by this person)
2016 Joice R, Frantzreb C, Pradham A, Seydel KB, Kamiza S, Wirth DF, Duraisingh MT, Molyneux ME, Taylor TE, Marti M, Milner DA. Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. PMID 26916076 DOI: 10.1038/Modpathol.2016.27  0.3
1989 Meredith SE, Unnasch TR, Karam M, Piessens WF, Wirth DF. Cloning and characterization of an Onchocerca volvulus specific DNA sequence. Molecular and Biochemical Parasitology. 36: 1-10. PMID 2811941 DOI: 10.1016/0166-6851(89)90194-1  0.298
2018 Larsen EM, Chang CF, Sakata-Kato T, Arico JW, Lombardo VM, Wirth DF, Taylor RE. Conformation-guided analogue design identifies potential antimalarial compounds through inhibition of mitochondrial respiration. Organic & Biomolecular Chemistry. PMID 30009295 DOI: 10.1039/C8Ob01257A  0.298
2012 Badiane AS, Sarr O, Deme AB, Ahouidi AD, Gueye PE, Ndiaye M, Seck MC, Diallo M, Bei AK, Duraisingh MT, Wirth D, Ndiaye D, Ndir O, Mboup S. Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal. Journal of Infection in Developing Countries. 6: 727-33. PMID 23103895 DOI: 10.3855/Jidc.2587  0.297
2002 Hirschmann F, Verhoeyen E, Wirth D, Bauwens S, Hauser H, Rudert M. Vital marking of articular chondrocytes by retroviral infection using green fluorescence protein. Osteoarthritis and Cartilage. 10: 109-118. PMID 11869070 DOI: 10.1053/Joca.2001.0486  0.297
2016 Silterra J, Gillette MA, Lanaspa M, Pellé KG, Valim C, Ahmad R, Acácio S, Almendinger KD, Tan Y, Madrid L, Alonso PL, Carr SA, Wiegand RC, Bassat Q, Mesirov JP, ... ... Wirth DF, et al. Transcriptional categorization of the etiology of pneumonia syndrome in pediatric patients in malaria endemic areas. The Journal of Infectious Diseases. PMID 27837008 DOI: 10.1093/Infdis/Jiw531  0.296
1982 Wirth DF, McMahon Pratt D. Rapid identification of Leishmania species by specific hybridization of kinetoplast DNA in cutaneous lesions Proceedings of the National Academy of Sciences of the United States of America. 79: 6999-7003. PMID 6960359 DOI: 10.1073/Pnas.79.22.6999  0.295
2003 Gunasekera AM, Patankar S, Schug J, Eisen G, Wirth DF. Drug-induced alterations in gene expression of the asexual blood forms of Plasmodium falciparum. Molecular Microbiology. 50: 1229-39. PMID 14622411 DOI: 10.1046/J.1365-2958.2003.03787.X  0.294
1989 Waters AP, Unnasch TR, Wirth DF, Mccutchan TF. Sequence of a small ribosomal RNA gene from Plasmodium lophurae Nucleic Acids Research. 17: 1763. PMID 2922293 DOI: 10.1093/Nar/17.4.1763  0.293
2023 Wong W, Schaffner SF, Thwing J, Seck MC, Gomis J, Diedhiou Y, Sy N, Ndiop M, Ba F, Diallo I, Sene D, Diallo MA, Ndiaye YD, Sy M, Sene A, ... ... Wirth DF, et al. Evaluating the performance of Plasmodium falciparum genetics for inferring National Malaria Control Program reported incidence in Senegal. Research Square. PMID 37961451 DOI: 10.21203/rs.3.rs-3516287/v1  0.29
2018 Wirth DF, Casamitjana N, Tanner M, Reich MR. Global action for training in malaria elimination. Malaria Journal. 17: 51. PMID 29370810 DOI: 10.1186/S12936-018-2199-3  0.288
2009 Wirth D, Daily J, Winzeler E, Mesirov JP, Regev A. In vivo profiles in malaria are consistent with a novel physiological state. Proceedings of the National Academy of Sciences of the United States of America. 106: E70; author reply E7. PMID 19570993 DOI: 10.1073/Pnas.0904478106  0.288
1985 Landfear SM, Wirth DF. Structure of mRNA encoded by tubulin genes in Leishmania enriettii Molecular and Biochemical Parasitology. 15: 61-82. PMID 3990710 DOI: 10.1016/0166-6851(85)90029-5  0.288
1987 Shah JS, Karam M, Piessens WF, Wirth DF. Characterization of an onchocerca-specific DNA clone from Onchocerca volvulus American Journal of Tropical Medicine and Hygiene. 37: 376-384. PMID 3661830 DOI: 10.4269/Ajtmh.1987.37.376  0.288
1990 Rodgers MR, Popper SJ, Wirth DF. Amplification of kinetoplast DNA as a tool in the detection and diagnosis of Leishmania Experimental Parasitology. 71: 267-275. PMID 2170165 DOI: 10.1016/0014-4894(90)90031-7  0.287
2011 Sandhu U, Cebula M, Behme S, Riemer P, Wodarczyk C, Metzger D, Reimann J, Schirmbeck R, Hauser H, Wirth D. Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells Nucleic Acids Research. 39: e1. PMID 20935052 DOI: 10.1093/Nar/Gkq868  0.287
2010 Urgaonkar S, Cortese JF, Barker RH, Cromwell M, Serrano AE, Wirth DF, Clardy J, Mazitschek R. A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity. Organic Letters. 12: 3998-4001. PMID 20718474 DOI: 10.1021/Ol101566H  0.282
2000 Acuna-Soto R, Maguire JH, Wirth DF. Original ContributionGender distribution in asymptomatic and invasive amebiasis The American Journal of Gastroenterology. 95. DOI: 10.1016/S0002-9270(99)00584-5  0.281
1986 Landfear SM, Miller SI, Wirth DF. Transcriptional mapping of Leishmania enriettii tubulin mRNAs Molecular and Biochemical Parasitology. 21: 235-245. PMID 3807944 DOI: 10.1016/0166-6851(86)90129-5  0.281
2024 Wong W, Schaffner SF, Thwing J, Seck MC, Gomis J, Diedhiou Y, Sy N, Ndiop M, Ba F, Diallo I, Sene D, Diallo MA, Ndiaye YD, Sy M, Sene A, ... ... Wirth DF, et al. Evaluating the performance of Plasmodium falciparum genetic metrics for inferring National Malaria Control Programme reported incidence in Senegal. Malaria Journal. 23: 68. PMID 38443939 DOI: 10.1186/s12936-024-04897-z  0.281
2000 Acuna-Soto R, Maguire JH, Wirth DF. Gender distribution in asymptomatic and invasive amebiasis American Journal of Gastroenterology. 95: 1277-1283. PMID 10811339 DOI: 10.1111/J.1572-0241.2000.01525.X  0.28
1987 Rogers WO, Wirth DF. Kinetoplast DNA minicircles: Regions of extensive sequence divergence Proceedings of the National Academy of Sciences of the United States of America. 84: 565-569. PMID 3025880 DOI: 10.1073/Pnas.84.2.565  0.28
2015 Valim C, Ahmad R, Lanaspa M, Tan Y, Acácio S, Gillette MA, Almendinger KD, Milner DA, Madrid L, Pellé K, Harezlak J, Silterra J, Alonso PL, Carr SA, Mesirov JP, ... Wirth DF, et al. Responses to Bacteria, Virus and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia. American Journal of Respiratory and Critical Care Medicine. PMID 26469764 DOI: 10.1164/Rccm.201506-1100Oc  0.276
1986 Lee Sim BK, Piessens WF, Wirth DF. A DNA probe cloned in Escherichia coli for the identification of Brugia malayi Molecular and Biochemical Parasitology. 19: 117-123. PMID 2425257 DOI: 10.1016/0166-6851(86)90116-7  0.276
2008 Mazitschek R, Patel V, Wirth DF, Clardy J. Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. Bioorganic & Medicinal Chemistry Letters. 18: 2809-12. PMID 18430569 DOI: 10.1016/J.Bmcl.2008.04.007  0.271
2005 Militello KT, Patel V, Chessler AD, Fisher JK, Kasper JM, Gunasekera A, Wirth DF. RNA polymerase II synthesizes antisense RNA in Plasmodium falciparum. Rna (New York, N.Y.). 11: 365-70. PMID 15703443 DOI: 10.1261/Rna.7940705  0.27
2021 Sy M, Badiane AS, Deme AB, Gaye A, Ndiaye T, Fall FB, Siddle KJ, Dieye B, Ndiaye YD, Diallo MA, Diongue K, Seck MC, Ndiaye IM, Cissé M, Gueye AB, ... ... Wirth DF, et al. Genomic investigation of atypical malaria cases in Kanel, northern Senegal. Malaria Journal. 20: 103. PMID 33608006 DOI: 10.1186/s12936-021-03637-x  0.269
1988 Rogers WO, Wirth DF. Generation of sequence diversity in the kinetoplast DNA minicircles of Leishmania mexicana amazonensis Molecular and Biochemical Parasitology. 30: 1-8. PMID 3398889 DOI: 10.1016/0166-6851(88)90126-0  0.269
2006 Coroadinha AS, Schucht R, Gama-Norton L, Wirth D, Hauser H, Carrondo MJT. The use of recombinase mediated cassette exchange in retroviral vector producer cell lines: predictability and efficiency by transgene exchange. Journal of Biotechnology. 124: 457-468. PMID 16529836 DOI: 10.1016/J.Jbiotec.2006.01.037  0.268
1993 Iralu JV, Sritharan VK, Pieciak WS, Wirth DF, Maguire JH, Barker RH. Diagnosis of Mycobacterium avium bacteremia by polymerase chain reaction Journal of Clinical Microbiology. 31: 1811-1814. PMID 8349758 DOI: 10.1128/Jcm.31.7.1811-1814.1993  0.267
2000 Patankar S, Fujioka H, Wirth DF. The signal sequence and C-terminal hydrophobic domain are required for localization of the sexual stage antigen Pgs28 to the surface of P. gallinaceum ookinetes Molecular and Biochemical Parasitology. 111: 425-435. PMID 11163448 DOI: 10.1016/S0166-6851(00)00340-6  0.266
1999 Saiz M, Ro YT, Wirth DF, Patterson JL. Host cell proteins bind specifically to the capsid-cleaved 5' end of Leishmaniavirus RNA. Journal of Biochemistry. 126: 538-44. PMID 10467169 DOI: 10.1093/Oxfordjournals.Jbchem.A022483  0.264
1993 Tobin JF, Wirth DF. Mutational analysis of a signal sequence required for protein secretion in Leishmania major Molecular and Biochemical Parasitology. 62: 243-249. PMID 8139617 DOI: 10.1016/0166-6851(93)90113-C  0.264
1989 Patel RJ, Piessens WF, David JR, Wirth DF. A Cloned DNA Fragment for Identification of Mycobacterium Tuberculosis Reviews of Infectious Diseases. 11: S411-S419. PMID 2496456 DOI: 10.1093/Clinids/11.Supplement_2.S411  0.259
1990 Fries JWU, Patel RJ, Piessens WF, Wirth DF. Genus- and species-specific DNA probes to identify mycobacteria using the polymerase chain reaction Molecular and Cellular Probes. 4: 87-105. PMID 2366764 DOI: 10.1016/0890-8508(90)90011-N  0.259
1994 Sánchez MA, Peattie DA, Wirth D, Orozco E. Cloning, genomic organization and transcription of the Entamoeba histolytica alpha-tubulin-encoding gene. Gene. 146: 239-44. PMID 8076825 DOI: 10.1016/0378-1119(94)90299-2  0.255
2010 Nehlsen K, Herrmann S, Zauers J, Hauser H, Wirth D. Toxin–antitoxin based transgene expression in mammalian cells Nucleic Acids Research. 38. PMID 20007149 DOI: 10.1093/Nar/Gkp1140  0.254
1986 Comeau AM, Miller SI, Wirth DF. Chromosome location of four genes in Leishmania Molecular and Biochemical Parasitology. 21: 161-169. PMID 3785294 DOI: 10.1016/0166-6851(86)90019-8  0.252
1996 Olliaro PL, Gottlieb M, Wirth DF. Plasmodium falciparum proteinases: Targeted drug development Parasitology Today. 12: 413-414. DOI: 10.1016/0169-4758(96)30028-8  0.251
1999 Herbst A, Koester M, Wirth D, Hauser H, Welte K. G-CSF receptor mutations in patients with severe congenital neutropenia do not abrogate Jak2 activation and stat1/stat3 translocation. Annals of the New York Academy of Sciences. 872: 320-327. PMID 10372134 DOI: 10.1111/J.1749-6632.1999.Tb08476.X  0.251
1989 Widmer G, Comeau AM, Furlong DB, Wirth DF, Patterson JL. Characterization of a RNA virus from the parasite Leishmania Proceedings of the National Academy of Sciences of the United States of America. 86: 5979-5982. PMID 2762308 DOI: 10.1073/Pnas.86.15.5979  0.247
1990 Patel RJ, Fries JWU, Piessens WF, Wirth DF. Sequence analysis and amplification by polymerase chain reaction of a cloned DNA fragment for identification of Mycobacterium tuberculosis Journal of Clinical Microbiology. 28: 513-518. PMID 2108994 DOI: 10.1128/Jcm.28.3.513-518.1990  0.244
1977 Robbins PW, Hubbard SC, Turco SJ, Wirth DF. Proposal for a common oligosaccharide intermediate in the synthesis of membrane glycoproteins. Cell. 12: 893-900. PMID 202393 DOI: 10.1016/0092-8674(77)90153-2  0.243
1991 Fries JWU, Patel RJ, Piessens WF, Wirth DF. Detection of untreated mycobacteria by using polymerase chain reaction and specific DNA probes Journal of Clinical Microbiology. 29: 1744-1747. PMID 1761699 DOI: 10.1128/Jcm.29.8.1744-1747.1991  0.242
1988 Miller SI, Wirth DF. trans splicing in Leishmania enriettii and identification of ribonucleoprotein complexes containing the spliced leader and U2 equivalent RNAs Molecular and Cellular Biology. 8: 2597-2603. PMID 3405214 DOI: 10.1128/Mcb.8.6.2597  0.242
1994 Driesel G, Wirth D, Stark K, Baumgarten R, Sucker U, Schreier E. Hepatitis C virus (HCV) genotype distribution in German isolates : studies on the sequence variability in the E2 and NS5 region Archives of Virology. 139: 379-388. PMID 7832643 DOI: 10.1007/Bf01310799  0.24
1979 Wirth DF, Lodish HF, Robbins PW. Requirements for the insertion of the Sindbis envelope glycoproteins into the endoplasmic reticulum membrane Journal of Cell Biology. 81: 154-162. PMID 479287 DOI: 10.1083/Jcb.81.1.154  0.228
1977 Wirth DF, Katz F, Small B, Lodish HF. How a single sindbis virus mRNA directs the synthesis of one soluble protein and two integral membrane glycoproteins Cell. 10: 253-263. PMID 837448 DOI: 10.1016/0092-8674(77)90219-7  0.227
1980 Senger DR, Wirth DF, Hynes RO. Transformation-specific secreted phosophoproteins. Nature. 286: 619-21. PMID 7402340 DOI: 10.1038/286619A0  0.226
2013 Volkman SK, Neafsey DE, Schaffner SF, Sabeti PC, Wirth DF. From Population Genomics to Elucidated Traits in Plasmodium Falciparum: Population Genomics, Genetic Diversity, and Association in Malaria Evolution of Virulence in Eukaryotic Microbes. 111-123. DOI: 10.1002/9781118308165.ch6  0.221
1979 Senger DR, Wirth DF, Hynes RO. Transformed mammalian cells secrete specific proteins and phosphoproteins. Cell. 16: 885-93. PMID 88265 DOI: 10.1016/0092-8674(79)90103-X  0.219
2010 Gama-Norton L, Herrmann S, Schucht R, Coroadinha AS, Löw R, Alves PM, Bartholomae CC, Schmidt M, Baum C, Schambach A, Hauser H, Wirth D. Retroviral vector performance in defined chromosomal Loci of modular packaging cell lines. Human Gene Therapy. 21: 979-91. PMID 20222806 DOI: 10.1089/Hum.2009.089  0.218
1987 Wirth DF, Barker RH. Malaria diagnosis Science. 236.  0.216
1994 Wong AKC, Curotto De Lafaille MA, Wirth DF. Identification of a cis-acting gene regulatory element from the lemdr1 locus of Leishmania enriettii Journal of Biological Chemistry. 269: 26497-26502. PMID 7929372  0.211
1997 Perkins ME, Volkman S, Wirth DF, Le Blancq SM. Characterizationof an ATP-binding cassette transporter in Cryptosporidium parvum Molecular and Biochemical Parasitology. 87: 117-122. PMID 9233681 DOI: 10.1016/S0166-6851(97)00053-4  0.204
1980 Senger DR, Wirth DF, Bryant C, Hynes RO. Transformation-specific secreted proteins. Cold Spring Harbor Symposia On Quantitative Biology. 44: 651-7. PMID 6933047 DOI: 10.1101/Sqb.1980.044.01.068  0.202
1997 OLLIARO P, WIRTH D. New Targets for Antimalarial Drug Discovery Journal of Pharmacy and Pharmacology. 49: 29-33. DOI: 10.1111/j.2042-7158.1997.tb06157.x  0.2
2021 Gillette MA, Mani DR, Uschnig C, Pellé KG, Madrid L, Acácio S, Lanaspa M, Alonso P, Valim C, Carr SA, Schaffner SF, MacInnis B, Milner DA, Bassat Q, Wirth DF. Biomarkers to distinguish bacterial from viral pediatric clinical pneumonia in a malaria endemic setting. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 33534888 DOI: 10.1093/cid/ciaa1843  0.198
1992 Tobin JF, Wirth DF. A sequence insertion targeting vector for Leishmania enriettii Journal of Biological Chemistry. 267: 4752-4758. PMID 1537857  0.197
2003 Hamoir J, Nemmar A, Halloy D, Wirth D, Vincke G, Vanderplasschen A, Nemery B, Gustin P. Effect of polystyrene particles on lung microvascular permeability in isolated perfused rabbit lungs: role of size and surface properties. Toxicology and Applied Pharmacology. 190: 278-285. PMID 12902199 DOI: 10.1016/S0041-008X(03)00192-3  0.196
1993 Fontanet AL, Johnston BD, Walker AM, Rooney W, Thimasarn K, Sturchler D, Macdonald M, Hours M, Wirth DF. High prevalence of mefloquine-resistant falciparum malaria in eastern Thailand Bulletin of the World Health Organization. 71: 377-383. PMID 8324857  0.192
1980 Lodish HF, Wirth D, Porter M. Synthesis and assembly of viral membrane proteins. Annals of the New York Academy of Sciences. 343: 319-37. PMID 6249165 DOI: 10.1111/J.1749-6632.1980.Tb47261.X  0.191
1989 Lanar DE, McLaughlin GL, Wirth DF, Barker RJ, Zolg JW, Chulay JD. Comparison of thick films, in vitro culture and DNA hybridization probes for detecting Plasmodium falciparum malaria. The American Journal of Tropical Medicine and Hygiene. 40: 3-6. PMID 2644856  0.182
1992 De Lafaille MAC, Wirth DF. Creation of null/+ mutants of the α-tubulin gene in Leishmania enriettii by gene cluster deletion Journal of Biological Chemistry. 267: 23839-23846. PMID 1429722  0.179
2023 Juraska M, Early AM, Li L, Schaffner SF, Lievens M, Khorgade A, Simpkins B, Hejazi NS, Benkeser DA, Wang Q, Mercer LD, Adjei S, Agbenyega T, Anderson S, Ansong D, ... ... Wirth DF, et al. Baseline malaria infection status and RTS,S/AS01E malaria vaccine efficacy. Medrxiv : the Preprint Server For Health Sciences. PMID 38045387 DOI: 10.1101/2023.11.22.23298907  0.178
2021 Chaudhury S, MacGill RS, Early AM, Bolton JS, King CR, Locke E, Pierson T, Wirth DF, Neafsey DE, Bergmann-Leitner ES. Breadth of humoral immune responses to the C-terminus of the circumsporozoite protein is associated with protective efficacy induced by the RTS,S malaria vaccine. Vaccine. PMID 33431225 DOI: 10.1016/j.vaccine.2020.12.055  0.161
1993 Tobin JF, Reiner SL, Hatam F, Zheng S, Leptak CL, Wirth DF, Locksley RM. Transfected Leishmania expressing biologically active IFN-γ Journal of Immunology. 150: 5059-5069. PMID 8098724  0.158
1979 Witte ON, Wirth DF. Structure of the murine leukemia virus envelope glycoprotein precursor Journal of Virology. 29: 735-743. PMID 430608  0.156
1988 Rogers WO, Burnheim PF, Wirth DF. Detection of Leishmania within sand flies by kinetoplast DNA hybridization American Journal of Tropical Medicine and Hygiene. 39: 434-439. PMID 2848422  0.119
1981 Robbins PW, Wirth DF, Hering C. Expression of the Streptomyces enzyme endoglycosidase H in Escherichia coli Journal of Biological Chemistry. 256: 10640-10644. PMID 6270125  0.112
1984 Robbins PW, Trimble RB, Wirth DF, Hering C, Maley F, Maley GF, Das R, Gibson BW, Royal N, Biemann K. Primary structure of the Streptomyces enzyme endo-beta-N-acetylglucosaminidase H. The Journal of Biological Chemistry. 259: 7577-83. PMID 6429133  0.105
2021 Wilkinson JE, Franzosa EA, Everett C, Li C, Hu FB, Wirth DF, Song M, Chan AT, Rimm E, Garrett WS, Huttenhower C. A framework for microbiome science in public health. Nature Medicine. PMID 33820996 DOI: 10.1038/s41591-021-01258-0  0.063
2013 Wirth DF, Roesler S, Silari M, Streit-Bianchi M, Theis C, Vincke H. Radiation protection at CERN Cern Accelerator School: High Power Hadron Machines, Cas 2011 - Proceedings. 415-436.  0.036
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