135 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sayama S, Song A, Brown BC, Couturier J, Cai X, Xu P, Chen C, Zheng Y, Iriyama T, Sibai B, Longo M, Kellems RE, D'Alessandro A, Xia Y. Maternal erythrocyte ENT1-mediated AMPK activation counteracts placental hypoxia and supports fetal growth. Jci Insight. 5. PMID 32434995 DOI: 10.1172/Jci.Insight.130205  0.379
2020 Xie T, Chen C, Peng Z, Brown BC, Reisz JA, Xu P, Zhou Z, Song A, Zhang Y, Bogdanov MV, Kellems RE, D'Alessandro A, Zhang W, Xia Y. Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies. Circulation Research. PMID 32284030 DOI: 10.1161/Circresaha.119.316298  0.347
2020 Iriyama T, Wang W, Parchim NF, Sayama S, Kumasawa K, Nagamatsu T, Song A, Xia Y, Kellems RE. Reciprocal upregulation of hypoxia-inducible factor-1α and persistently enhanced placental adenosine signaling contribute to the pathogenesis of preeclampsia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31930569 DOI: 10.1096/Fj.201902583R  0.374
2019 Adebiyi MG, Zhao Z, Ye Y, Manalo J, Hong Y, Lee CC, Xian W, McKeon F, Culp-Hill R, D' Alessandro A, Kellems RE, Yoo SH, Han L, Xia Y. Circadian period 2: a missing beneficial factor in sickle cell disease by lowering pulmonary inflammation, iron overload, and mortality. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900246RR. PMID 31260634 DOI: 10.1096/Fj.201900246Rr  0.354
2019 Liu C, Luo R, Wang W, Peng Z, Johnson GVW, Kellems RE, Xia Y. Tissue transglutaminase-mediated AT1 receptor sensitization underlies pro-inflammatory cytokine LIGHT-induced hypertension. American Journal of Hypertension. PMID 30715101 DOI: 10.1093/Ajh/Hpz018  0.362
2018 Liu H, Adebiyi M, Liu RR, Song A, Manalo J, Wen YE, Wen AQ, Weng T, Ko J, Idowu M, Kellems RE, Eltzschig HK, Blackburn MR, Juneja HS, Xia Y. Elevated ecto-5'-nucleotidase: a missing pathogenic factor and new therapeutic target for sickle cell disease. Blood Advances. 2: 1957-1968. PMID 30097462 DOI: 10.1182/Bloodadvances.2018015784  0.384
2018 Zhao S, Adebiyi MG, Zhang Y, Couturier JP, Fan X, Zhang H, Kellems RE, Lewis DE, Xia Y. Sphingosine-1-phosphate receptor 1 mediates elevated IL-6 signaling to promote chronic inflammation and multitissue damage in sickle cell disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201600788RR. PMID 29401601 DOI: 10.1096/Fj.201600788Rr  0.37
2018 Liu H, Liu R, Nemkov T, Couturier J, Liang L, Song A, Zhao S, Sun K, Adebiyi M, Wen YE, Wen A, Liu J, Kellems R, D'Alessandro A, Blackburn M, et al. Adenosine A2B Receptor Controls Erythroid Lineage Commitment in Stress Erythropoiesis By Promoting Metabolic Reprogramming Blood. 132: 845-845. DOI: 10.1182/Blood-2018-99-114075  0.386
2017 Sun K, D'Alessandro A, Ahmed MH, Zhang Y, Song A, Ko TP, Nemkov T, Reisz JA, Wu H, Adebiyi M, Peng Z, Gong J, Liu H, Huang A, Wen YE, ... ... Kellems RE, et al. Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease. Scientific Reports. 7: 15281. PMID 29127281 DOI: 10.1038/s41598-017-13667-8  0.302
2017 Xiang Y, Ye Y, Lou Y, Yang Y, Cai C, Zhang Z, Mills T, Chen NY, Kim Y, Muge Ozguc F, Diao L, Karmouty-Quintana H, Xia Y, Kellems RE, Chen Z, et al. Comprehensive Characterization of Alternative Polyadenylation in Human Cancer. Journal of the National Cancer Institute. PMID 29106591 DOI: 10.1093/Jnci/Djx223  0.303
2017 Huang A, Wu H, Iriyama T, Zhang Y, Sun K, Song A, Liu H, Peng Z, Tang L, Lee M, Huang Y, Ni X, Kellems RE, Xia Y. Elevated Adenosine Induces Placental DNA Hypomethylation Independent of A2B Receptor Signaling in Preeclampsia. Hypertension (Dallas, Tex. : 1979). PMID 28507174 DOI: 10.1161/Hypertensionaha.117.09536  0.421
2017 Liu C, Kellems RE, Xia Y. Inflammation, Autoimmunity, and Hypertension: The Essential Role of Tissue Transglutaminase. American Journal of Hypertension. PMID 28338973 DOI: 10.1093/Ajh/Hpx027  0.359
2017 Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, ... ... Kellems RE, et al. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nature Communications. 8: 14108. PMID 28169986 DOI: 10.1038/Ncomms14108  0.332
2016 Liu H, Zhang Y, Wu H, D'Alessandro A, Yegutkin GG, Song A, Sun K, Li J, Cheng NY, Huang A, Edward Wen Y, Weng TT, Luo F, Nemkov T, Sun H, ... Kellems RE, et al. Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia. Circulation. 134: 405-21. PMID 27482003 DOI: 10.1161/Circulationaha.116.021311  0.324
2016 Wu H, Bogdanov M, Zhang Y, Sun K, Zhao S, Song A, Luo R, Parchim NF, Liu H, Huang A, Adebiyi MG, Jin J, Alexander DC, Milburn MV, Idowu M, ... ... Kellems RE, et al. Hypoxia-mediated impaired erythrocyte Lands' Cycle is pathogenic for sickle cell disease. Scientific Reports. 6: 29637. PMID 27436223 DOI: 10.1038/Srep29637  0.363
2016 Luo R, Liu C, Elliott SE, Wang W, Parchim N, Iriyama T, Daugherty PS, Tao L, Eltzschig HK, Blackwell SC, Sibai BM, Kellems RE, Xia Y. Transglutaminase is a Critical Link Between Inflammation and Hypertension. Journal of the American Heart Association. 5. PMID 27364991 DOI: 10.1161/Jaha.116.003730  0.359
2016 Hu X, Adebiyi MG, Luo J, Sun K, Le TT, Zhang Y, Wu H, Zhao S, Karmouty-Quintana H, Liu H, Huang A, Wen YE, Zaika OL, Mamenko M, Pochynyuk OM, ... Kellems RE, et al. Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction. Cell Reports. PMID 27320922 DOI: 10.1016/J.Celrep.2016.05.080  0.311
2016 Song A, Zhang Y, Liu H, Sun K, Peng Z, Wu H, Kellems RE, Roach R, Xia Y. Erythrocytes Retain "Hypoxic Purinergic Memory" for Faster Acclimatization upon Re-Ascent Blood. 128: 4854-4854. DOI: 10.1182/Blood.V128.22.4854.4854  0.314
2016 Zhang Y, Zhao S, Couturier J, Kellems RE, Lewis DL, Xia Y. S1P Receptor 1-Mediatd Elevated IL-6 Signaling Underlies Chronic Inflammation and Multiple Tissue Damage in Sickle Cell Disease Blood. 128: 4849-4849. DOI: 10.1182/Blood.V128.22.4849.4849  0.34
2016 Liu H, Zhang Y, D'Alessandro A, Nemkov T, Couturier J, Zhao S, Hansen KC, Lovering AT, Roach R, Kellems RE, Eltzschig HK, Blackburn MR, Xia Y. Adenosine Signaling-Mediated Metabolic Reprogramming Regulates Erythropoiesis Blood. 128: 2437-2437. DOI: 10.1182/Blood.V128.22.2437.2437  0.316
2016 Peng Z, Luo R, Song A, Sun K, Liu H, Zhang Y, Adebiyi MG, Xia Y, Kellems RE, Huang A. Adenosine A2B Receptor Promotes Erythrocyte Oxygen Release to Counteract Tissue Hypoxia and Injury Blood. 128: 2424-2424. DOI: 10.1182/Blood.V128.22.2424.2424  0.355
2015 Liu C, Luo R, Elliott SE, Wang W, Parchim NF, Iriyama T, Daugherty PS, Blackwell SC, Sibai BM, Kellems RE, Xia Y. Elevated Transglutaminase Activity Triggers Angiotensin Receptor Activating Autoantibody Production and Pathophysiology of Preeclampsia. Journal of the American Heart Association. 4. PMID 26675250 DOI: 10.1161/Jaha.115.002323  0.397
2015 Iriyama T, Sun K, Parchim NF, Li J, Zhao C, Song A, Hart LA, Blackwell SC, Sibai BM, Chan LN, Chan TS, Hicks JM, Blackburn MR, Kellems RE, Xia Y. Response to Letter Regarding Article, "Elevated Placental Adenosine Signaling Contributes to the Pathogenesis of Preeclampsia". Circulation. 132: e222-3. PMID 26527698 DOI: 10.1161/Circulationaha.115.017262  0.324
2015 Luo R, Zhang W, Zhao C, Zhang Y, Wu H, Jin J, Zhang W, Grenz A, Eltzschig HK, Tao L, Kellems RE, Xia Y. Elevated Endothelial Hypoxia-Inducible Factor-1α Contributes to Glomerular Injury and Promotes Hypertensive Chronic Kidney Disease. Hypertension. 66: 75-84. PMID 25987665 DOI: 10.1161/Hypertensionaha.115.05578  0.344
2015 Iriyama T, Wang W, Parchim NF, Song A, Blackwell SC, Sibai BM, Kellems RE, Xia Y. Hypoxia-independent upregulation of placental hypoxia inducible factor-1α gene expression contributes to the pathogenesis of preeclampsia. Hypertension. 65: 1307-15. PMID 25847948 DOI: 10.1161/Hypertensionaha.115.05314  0.377
2015 Luo R, Liu C, Elliott S, Wang W, Daugherty P, Kellems RE, Xia Y. [259-POS]: Elevated ransglutaminase promotes the production of AT1-AA in preeclampsia. Pregnancy Hypertension. 5: 130. PMID 25787609 DOI: 10.1016/J.Preghy.2014.10.265  0.386
2015 Parchim N, Wang W, Iriyama T, Ashimi OA, Liu C, Siddiqui AH, Blackwell S, Sibai B, Kellems RE, Xia Y. [169-POS] : Elevated C-reactive protein contributes to preeclampsia via kinin signaling pathways. Pregnancy Hypertension. 5: 87. PMID 25787519 DOI: 10.1016/J.Preghy.2014.10.175  0.397
2015 Iriyama T, Sun K, Parchim N, Lee J, Blackwell S, Sibai B, Chan LN, Chan TS, Blackburn M, Kellems R, Xia Y. [89-OR]: Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia. Pregnancy Hypertension. 5: 48. PMID 25787439 DOI: 10.1016/J.Preghy.2014.10.093  0.444
2015 Sun K, Zhang Y, Bogdanov MV, Wu H, Song A, Li J, Dowhan W, Idowu M, Juneja HS, Molina JG, Blackburn MR, Kellems RE, Xia Y. Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity. Blood. 125: 1643-52. PMID 25587035 DOI: 10.1182/Blood-2014-08-595751  0.431
2015 Iriyama T, Sun K, Parchim NF, Li J, Zhao C, Song A, Hart LA, Blackwell SC, Sibai BM, Chan LN, Chan TS, Hicks MJ, Blackburn MR, Kellems RE, Xia Y. Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia. Circulation. 131: 730-41. PMID 25538227 DOI: 10.1161/Circulationaha.114.013740  0.334
2015 Parchim NF, Wang W, Iriyama T, Ashimi OA, Siddiqui AH, Blackwell S, Sibai B, Kellems RE, Xia Y. Neurokinin 3 receptor and phosphocholine transferase: missing factors for pathogenesis of C-reactive protein in preeclampsia. Hypertension. 65: 430-9. PMID 25452470 DOI: 10.1161/Hypertensionaha.114.04439  0.389
2015 Adebiyi MG, Hu X, Luo J, Sun K, Le TT, Zhang Y, Wu H, Liu H, Huang A, Kellems RE, Blackburn MR, Walters ET, Hu H, Xia Y. Sustained Elevation of Adenosine-ADORA2B Signaling Promotes Chronic Pain through Neuro-Immune Interaction in Sickle Cell Disease Blood. 126: 974-974. DOI: 10.1182/Blood.V126.23.974.974  0.316
2014 Zhang Y, Berka V, Song A, Sun K, Wang W, Zhang W, Ning C, Li C, Zhang Q, Bogdanov M, Alexander DC, Milburn MV, Ahmed MH, Lin H, Idowu M, ... ... Kellems RE, et al. Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. The Journal of Clinical Investigation. 124: 2750-61. PMID 24837436 DOI: 10.1172/Jci74604  0.343
2014 Ning C, Wen J, Zhang Y, Dai Y, Wang W, Zhang W, Qi L, Grenz A, Eltzschig HK, Blackburn MR, Kellems RE, Xia Y. Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2725-35. PMID 24614760 DOI: 10.1096/Fj.13-247833  0.456
2014 Elliott SE, Parchim NF, Liu C, Xia Y, Kellems RE, Soffici AR, Daugherty PS. Characterization of antibody specificities associated with preeclampsia. Hypertension. 63: 1086-93. PMID 24446060 DOI: 10.1161/Hypertensionaha.113.02362  0.301
2014 Wang W, Parchim NF, Iriyama T, Luo R, Zhao C, Liu C, Irani RA, Zhang W, Ning C, Zhang Y, Blackwell SC, Chen L, Tao L, Hicks MJ, Kellems RE, et al. Excess LIGHT contributes to placental impairment, increased secretion of vasoactive factors, hypertension, and proteinuria in preeclampsia. Hypertension. 63: 595-606. PMID 24324043 DOI: 10.1161/Hypertensionaha.113.02458  0.401
2014 Liu C, Wang W, Parchim N, Irani RA, Blackwell SC, Sibai B, Jin J, Kellems RE, Xia Y. Tissue transglutaminase contributes to the pathogenesis of preeclampsia and stabilizes placental angiotensin receptor type 1 by ubiquitination-preventing isopeptide modification. Hypertension. 63: 353-61. PMID 24191290 DOI: 10.1161/Hypertensionaha.113.02361  0.439
2014 Zhang Y, Zhao S, Wu H, Hu X, Luo R, Parchim N, Kellems RE, Xia Y. Sphingosine 1-Phosphate (S1P)/S1P Receptor 1 Pathway Has an Essential Role for Sickle Cell Disease Blood. 124: 4063-4063. DOI: 10.1182/Blood.V124.21.4063.4063  0.372
2014 Song A, Zhao C, Zhang Y, Li J, Blackburn MR, Grenz A, Eltzschig H, Kellems RE, Xia Y. Functions and Regulation of Erythrocyte Equlibrative Nucleoside Transporter 1 (ENT1) in Acute Hypoxia Mediated Tissue Injury Blood. 124: 2666-2666. DOI: 10.1182/Blood.V124.21.2666.2666  0.398
2014 Liu H, Zhang Y, Song A, Karmouty Quintana H, Grenz A, Sun H, Kellems RE, Eltzschig H, Roach R, Blackburn MR, Xia Y. Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Prevents Hypoxia-Induced Tissue Injury in High Altitude By Inducing 2,3-Bisphosphoglycerate Blood. 124: 2664-2664. DOI: 10.1182/Blood.V124.21.2664.2664  0.365
2013 Xia Y, Kellems RE. Angiotensin receptor agonistic autoantibodies and hypertension: preeclampsia and beyond. Circulation Research. 113: 78-87. PMID 23788505 DOI: 10.1161/Circresaha.113.300752  0.374
2013 Siddiqui AH, Irani RA, Zhang W, Wang W, Blackwell SC, Kellems RE, Xia Y. Angiotensin receptor agonistic autoantibody-mediated soluble fms-like tyrosine kinase-1 induction contributes to impaired adrenal vasculature and decreased aldosterone production in preeclampsia. Hypertension. 61: 472-9. PMID 23283357 DOI: 10.1161/Hypertensionaha.111.00157  0.382
2013 Zhang Y, Liu H, Sun K, Song A, Karmouty-Quintana H, Chen N, Grenz A, Kellems RE, Idowu M, Juneja HS, Roach R, Eltzschig H, Blackburn MR, Xia Y. Adenosine Is A Common Factor Regulating Erythrocyte 2,3-Bisphosphate Induction In Normal Individuals At High Altitude and In Patients With Sickle Cell Disease Blood. 122: 952-952. DOI: 10.1182/Blood.V122.21.952.952  0.383
2013 Kaiqi S, Zhang Y, Berka V, Kellems RE, Tsai A, Idowu M, Juneja HS, Xia Y. Role and Regulation Of Erythrocyte Sphingosine Kinase 1 Activity In Normal and Sickle Cell Disease Blood. 122: 315-315. DOI: 10.1182/Blood.V122.21.315.315  0.431
2013 Siddiqui AH, Irani RA, Zhang W, Wang W, Blackwell SC, Kellems RE, Xia Y. Erratum: Angiotensin Receptor Agonistic Autoantibody-Mediated Soluble Fms-Like Tyrosine Kinase-1 Induction Contributes to Impaired Adrenal Vasculature and Decreased Aldosterone Production in Preeclampsia (Hypertension (2013) 61 (472-479)) Hypertension. 61. DOI: 10.1161/Hyp.0B013E3182949149  0.359
2012 Wang W, Irani RA, Zhang Y, Kellems RE, Xia Y. OS069. Light, a TNF superfamily member, contributes to pathophysiology in a mouse model of preeclampsia. Pregnancy Hypertension. 2: 214. PMID 26105284 DOI: 10.1016/J.Preghy.2012.04.070  0.381
2012 Liu C, Wang W, Parchim NF, Irani RA, Ning C, Sun K, Kellems RE, Xia Y. OS057. Pathophysiological role of elevated tissue transglutaminase in autoantibody-induced features of preeclampsia in pregnant mice. Pregnancy Hypertension. 2: 208. PMID 26105271 DOI: 10.1016/J.Preghy.2012.04.058  0.379
2012 Wang W, Irani RA, Zhang Y, Ramin SM, Blackwell SC, Tao L, Kellems RE, Xia Y. Autoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia. Hypertension. 60: 712-21. PMID 22868393 DOI: 10.1161/Hypertensionaha.112.191817  0.404
2012 Ning C, Qi L, Wen J, Zhang Y, Zhang W, Wang W, Blackburn M, Kellems R, Xia Y. Excessive penile norepinephrine level underlies impaired erectile function in adenosine A1 receptor deficient mice. The Journal of Sexual Medicine. 9: 2552-61. PMID 22862844 DOI: 10.1111/J.1743-6109.2012.02896.X  0.361
2012 Zhou CC, Chang J, Mi T, Abbasi S, Gu D, Huang L, Zhang W, Kellems RE, Schwartz RJ, Xia Y. Targeted expression of Cre recombinase provokes placental-specific DNA recombination in transgenic mice. Plos One. 7: e29236. PMID 22363401 DOI: 10.1371/Journal.Pone.0029236  0.411
2012 Zhang W, Wang W, Yu H, Zhang Y, Dai Y, Ning C, Tao L, Sun H, Kellems RE, Blackburn MR, Xia Y. Interleukin 6 underlies angiotensin II-induced hypertension and chronic renal damage. Hypertension. 59: 136-44. PMID 22068875 DOI: 10.1161/Hypertensionaha.111.173328  0.348
2012 Song A, Zhang Y, Ning C, Grenz A, Etlzschig H, Kellems RE, Juneja HS, Xia Y. Reduced Erythrocyte Equlibrative Nucleoside Transporter Expression Underlies Increased Circulating Adenosine Levels and Contributes to Pathophysiology of Sickle Cell Disease Blood. 120: 3232-3232. DOI: 10.1182/blood.v120.21.3232.3232  0.32
2011 Xia Y, Kellems RE. Receptor-activating autoantibodies and disease: preeclampsia and beyond. Expert Review of Clinical Immunology. 7: 659-74. PMID 21895478 DOI: 10.1586/Eci.11.56  0.38
2011 Wen J, Dai Y, Zhang Y, Zhang W, Kellems RE, Xia Y. Impaired erectile function in CD73-deficient mice with reduced endogenous penile adenosine production. The Journal of Sexual Medicine. 8: 2172-80. PMID 21595838 DOI: 10.1111/J.1743-6109.2011.02316.X  0.315
2011 Wen J, Grenz A, Zhang Y, Dai Y, Kellems RE, Blackburn MR, Eltzschig HK, Xia Y. A2B adenosine receptor contributes to penile erection via PI3K/AKT signaling cascade-mediated eNOS activation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2823-30. PMID 21566208 DOI: 10.1096/Fj.11-181057  0.344
2011 Dai Y, Zhang W, Wen J, Zhang Y, Kellems RE, Xia Y. A2B adenosine receptor-mediated induction of IL-6 promotes CKD. Journal of the American Society of Nephrology : Jasn. 22: 890-901. PMID 21511827 DOI: 10.1681/Asn.2010080890  0.345
2011 Zhou CC, Irani RA, Dai Y, Blackwell SC, Hicks MJ, Ramin SM, Kellems RE, Xia Y. Autoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsia. Journal of Immunology (Baltimore, Md. : 1950). 186: 6024-34. PMID 21482739 DOI: 10.4049/Jimmunol.1004026  0.381
2011 Siddiqui AH, Irani RA, Zhang Y, Dai Y, Blackwell SC, Ramin SM, Kellems RE, Xia Y. Recombinant vascular endothelial growth factor 121 attenuates autoantibody-induced features of pre-eclampsia in pregnant mice. American Journal of Hypertension. 24: 606-12. PMID 21183928 DOI: 10.1038/Ajh.2010.247  0.371
2011 Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV, Carter-Dawson L, Lewis DE, Zhang W, Eltzschig HK, Kellems RE, et al. Detrimental effects of adenosine signaling in sickle cell disease. Nature Medicine. 17: 79-86. PMID 21170046 DOI: 10.1038/Nm.2280  0.396
2010 Irani RA, Zhang Y, Zhou CC, Blackwell SC, Hicks MJ, Ramin SM, Kellems RE, Xia Y. Autoantibody-mediated angiotensin receptor activation contributes to preeclampsia through tumor necrosis factor-alpha signaling. Hypertension. 55: 1246-53. PMID 20351341 DOI: 10.1161/Hypertensionaha.110.150540  0.315
2010 Zhou CC, Irani RA, Zhang Y, Blackwell SC, Mi T, Wen J, Shelat H, Geng YJ, Ramin SM, Kellems RE, Xia Y. Angiotensin receptor agonistic autoantibody-mediated tumor necrosis factor-alpha induction contributes to increased soluble endoglin production in preeclampsia. Circulation. 121: 436-44. PMID 20065159 DOI: 10.1161/Circulationaha.109.902890  0.352
2010 Siddiqui AH, Irani RA, Blackwell SC, Ramin SM, Kellems RE, Xia Y. Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: correlation with disease severity. Hypertension. 55: 386-93. PMID 19996068 DOI: 10.1161/Hypertensionaha.109.140061  0.357
2010 Wen J, Jiang X, Dai Y, Zhang Y, Tang Y, Sun H, Mi T, Phatarpekar PV, Kellems RE, Blackburn MR, Xia Y. Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 740-9. PMID 19858092 DOI: 10.1096/Fj.09-144147  0.398
2010 Wen J, Jiang X, Dai Y, Zhang Y, Tang Y, Sun H, Mi T, Kellems RE, Blackburn MR, Xia Y. Adenosine deaminase enzyme therapy prevents and reverses the heightened cavernosal relaxation in priapism. The Journal of Sexual Medicine. 7: 3011-22. PMID 19845544 DOI: 10.1111/J.1743-6109.2009.01552.X  0.308
2009 Irani RA, Zhang Y, Blackwell SC, Zhou CC, Ramin SM, Kellems RE, Xia Y. The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia. The Journal of Experimental Medicine. 206: 2809-22. PMID 19887397 DOI: 10.1084/Jem.20090872  0.401
2009 Xia Y, Kellems RE. Is preeclampsia an autoimmune disease? Clinical Immunology (Orlando, Fla.). 133: 1-12. PMID 19501024 DOI: 10.1016/J.Clim.2009.05.004  0.411
2009 Zhang Y, Dai Y, Wen J, Kellems RE, Blackburn MR, Juneja HS, Xia Y. Detrimental Role of Excess Adenosine-Mediated 2,3-Diphosphoglycerate Induction in Erythrocyte Sickling and Novel Mechanism-Based Therapies. Blood. 114: 906-906. DOI: 10.1182/Blood.V114.22.906.906  0.415
2008 Zhou CC, Zhang Y, Irani RA, Zhang H, Mi T, Popek EJ, Hicks MJ, Ramin SM, Kellems RE, Xia Y. Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice. Nature Medicine. 14: 855-62. PMID 18660815 DOI: 10.1038/Nm.1856  0.406
2008 Mi T, Abbasi S, Zhang H, Uray K, Chunn JL, Xia LW, Molina JG, Weisbrodt NW, Kellems RE, Blackburn MR, Xia Y. Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. The Journal of Clinical Investigation. 118: 1491-501. PMID 18340377 DOI: 10.1172/Jci33467  0.406
2008 Zhou CC, Ahmad S, Mi T, Abbasi S, Xia L, Day MC, Ramin SM, Ahmed A, Kellems RE, Xia Y. Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling. Hypertension. 51: 1010-9. PMID 18259044 DOI: 10.1161/Hypertensionaha.107.097790  0.44
2007 Xia Y, Zhou CC, Ramin SM, Kellems RE. Angiotensin receptors, autoimmunity, and preeclampsia. Journal of Immunology (Baltimore, Md. : 1950). 179: 3391-5. PMID 17785770 DOI: 10.4049/Jimmunol.179.6.3391  0.383
2007 Mohsenin A, Mi T, Xia Y, Kellems RE, Chen JF, Blackburn MR. Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 293: L753-61. PMID 17601796 DOI: 10.1152/Ajplung.00187.2007  0.338
2007 Xia Y, Ramin SM, Kellems RE. Potential roles of angiotensin receptor-activating autoantibody in the pathophysiology of preeclampsia. Hypertension. 50: 269-75. PMID 17576854 DOI: 10.1161/Hypertensionaha.107.091322  0.395
2007 Zhou CC, Ahmad S, Mi T, Xia L, Abbasi S, Hewett PW, Sun C, Ahmed A, Kellems RE, Xia Y. Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy. Circulation Research. 100: 88-95. PMID 17158338 DOI: 10.1161/01.Res.0000254703.11154.18  0.371
2007 Yuan J, Chunn JL, Mi T, Molina JG, Abbasi S, Sun C, Zhang J, Miller CS, Westney OL, Blackburn MR, Kellems RE, Xia Y, Wang R. 676: Adenosine Deaminase Knockout in Mice Induces Priapism VIA A2B Receptor Journal of Urology. 177: 227-227. DOI: 10.1016/S0022-5347(18)30916-9  0.348
2006 Carbonaro DA, Jin X, Petersen D, Wang X, Dorey F, Kil KS, Aldrich M, Blackburn MR, Kellems RE, Kohn DB. In vivo transduction by intravenous injection of a lentiviral vector expressing human ADA into neonatal ADA gene knockout mice: a novel form of enzyme replacement therapy for ADA deficiency. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 1110-20. PMID 16651028 DOI: 10.1016/J.Ymthe.2006.02.013  0.756
2006 Abbasi S, Lee JD, Su B, Chen X, Alcon JL, Yang J, Kellems RE, Xia Y. Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1. The Journal of Biological Chemistry. 281: 7717-26. PMID 16415348 DOI: 10.1074/Jbc.M510775200  0.345
2006 Schaubach BM, Wen HY, Kellems RE. Regulation of murine Ada gene expression in the placenta by transcription factor RUNX1. Placenta. 27: 269-77. PMID 16338472 DOI: 10.1016/J.Placenta.2005.03.001  0.657
2006 Chunn JL, Mohsenin A, Young HW, Lee CG, Elias JA, Kellems RE, Blackburn MR. Partially adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevations. American Journal of Physiology. Lung Cellular and Molecular Physiology. 290: L579-87. PMID 16258000 DOI: 10.1152/Ajplung.00258.2005  0.348
2005 Abbasi S, Su B, Kellems RE, Yang J, Xia Y. The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated T-cells activation. The Journal of Biological Chemistry. 280: 36737-46. PMID 16126726 DOI: 10.1074/Jbc.M506493200  0.398
2005 Wen HY, Abbasi S, Kellems RE, Xia Y. mTOR: A placental growth signaling sensor Placenta. 26. PMID 15837070 DOI: 10.1016/J.Placenta.2005.02.004  0.315
2005 Bobst SM, Day MC, Gilstrap LC, Xia Y, Kellems RE. Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretion. American Journal of Hypertension. 18: 330-6. PMID 15797649 DOI: 10.1016/J.Amjhyper.2004.10.002  0.747
2005 Blackburn MR, Kellems RE. Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation. Advances in Immunology. 86: 1-41. PMID 15705418 DOI: 10.1016/S0065-2776(04)86001-2  0.385
2004 Thway TM, Shlykov SG, Day MC, Sanborn BM, Gilstrap LC, Xia Y, Kellems RE. Antibodies from preeclamptic patients stimulate increased intracellular Ca2+ mobilization through angiotensin receptor activation. Circulation. 110: 1612-9. PMID 15381659 DOI: 10.1161/01.Cir.0000142855.68398.3A  0.37
2003 Aldrich MB, Chen W, Blackburn MR, Martinez-Valdez H, Datta SK, Kellems RE. Impaired germinal center maturation in adenosine deaminase deficiency. Journal of Immunology (Baltimore, Md. : 1950). 171: 5562-70. PMID 14607964 DOI: 10.4049/Jimmunol.171.10.5562  0.352
2003 Li M, Kellems RE. Sp1 and Sp3 Are important regulators of AP-2gamma gene transcription. Biology of Reproduction. 69: 1220-30. PMID 12801994 DOI: 10.1095/Biolreprod.103.015545  0.373
2003 Xia Y, Wen H, Bobst S, Day MC, Kellems RE. Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human trophoblast cells. Journal of the Society For Gynecologic Investigation. 10: 82-93. PMID 12593997 DOI: 10.1016/S1071-5576(02)00259-9  0.747
2003 Xia Y, Wen HY, Young ME, Guthrie PH, Taegtmeyer H, Kellems RE. Mammalian target of rapamycin and protein kinase A signaling mediate the cardiac transcriptional response to glutamine. The Journal of Biological Chemistry. 278: 13143-50. PMID 12522136 DOI: 10.1074/Jbc.M208500200  0.335
2002 Wen HY, Xia Y, Young ME, Taegtmeyer H, Kellems RE. The adenylosuccinate synthetase-1 gene is activated in the hypertrophied heart. Journal of Cellular and Molecular Medicine. 6: 235-43. PMID 12169208 DOI: 10.1111/J.1582-4934.2002.Tb00190.X  0.407
2002 Xia Y, Wen HY, Kellems RE. Angiotensin II inhibits human trophoblast invasion through AT1 receptor activation. The Journal of Biological Chemistry. 277: 24601-8. PMID 11983698 DOI: 10.1074/Jbc.M201369200  0.393
2002 Xia Y, Wen H, Prashner HR, Chen R, Inagami T, Catanzaro DF, Kellems RE. Pregnancy-induced changes in renin gene expression in mice. Biology of Reproduction. 66: 135-43. PMID 11751275 DOI: 10.1095/Biolreprod66.1.135  0.422
2002 Wen H, Xia Y, Lewis A, Kellems RE. 12 Hand 1 and hand 2 proteins regulate cardiac expression of the murine adenylosuccinate synthetase 1 gene in the murine heart Journal of Molecular and Cellular Cardiology. 34: A41. DOI: 10.1016/S0022-2828(02)90220-8  0.317
2001 Apasov SG, Blackburn MR, Kellems RE, Smith PT, Sitkovsky MV. Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling Journal of Clinical Investigation. 108: 131-141. PMID 11435465 DOI: 10.1172/Jci10360  0.351
2000 Aldrich MB, Blackburn MR, Datta SK, Kellems RE. Adenosine deaminase-deficient mice: models for the study of lymphocyte development and adenosine signaling. Advances in Experimental Medicine and Biology. 486: 57-63. PMID 11783528 DOI: 10.1007/0-306-46843-3_11  0.325
2000 Thompson LF, Van de Wiele CJ, Laurent AB, Hooker SW, Vaughn JG, Jiang H, Khare K, Kellems RE, Blackburn MR, Hershfield MS, Resta R. Metabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ cultures. The Journal of Clinical Investigation. 106: 1149-57. PMID 11067867 DOI: 10.1172/Jci9944  0.419
2000 Blackburn MR, Aldrich M, Volmer JB, Chen W, Zhong H, Kelly S, Hershfield MS, Datta SK, Kellems RE. The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities. The Journal of Biological Chemistry. 275: 32114-21. PMID 10908569 DOI: 10.1074/Jbc.M005153200  0.323
2000 Blackburn MR, Volmer JB, Thrasher JL, Zhong H, Crosby JR, Lee JJ, Kellems RE. Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction. The Journal of Experimental Medicine. 192: 159-70. PMID 10899903 DOI: 10.1084/Jem.192.2.159  0.325
2000 Aldrich MB, Blackburn MR, Kellems RE. The importance of adenosine deaminase for lymphocyte development and function. Biochemical and Biophysical Research Communications. 272: 311-5. PMID 10833410 DOI: 10.1006/Bbrc.2000.2773  0.326
2000 Xu PA, Kellems RE. Function of murine adenosine deaminase in the gastrointestinal tract Biochemical and Biophysical Research Communications. 269: 749-757. PMID 10720488 DOI: 10.1006/Bbrc.2000.2357  0.387
2000 Xia Y, McMillin JB, Lewis A, Moore M, Zhu WG, Williams RS, Kellems RE. Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene Journal of Biological Chemistry. 275: 1855-1863. PMID 10636885 DOI: 10.1074/Jbc.275.3.1855  0.375
1999 Lewis AL, Xia Y, Datta SK, McMillin J, Kellems RE. Combinatorial interactions regulate cardiac expression of the murine adenylosuccinate synthetase 1 gene. The Journal of Biological Chemistry. 274: 14188-97. PMID 10318837 DOI: 10.1074/Jbc.274.20.14188  0.377
1999 Xu PA, Winston JH, Datta SK, Kellems RE. Regulation of forestomach-specific expression of the murine adenosine deaminase gene Journal of Biological Chemistry. 274: 10316-10323. PMID 10187819 DOI: 10.1074/Jbc.274.15.10316  0.44
1998 Shi D, Kellems RE. Transcription factor AP-2γ regulates murine adenosine deaminase gene expression during placental development Journal of Biological Chemistry. 273: 27331-27338. PMID 9765260 DOI: 10.1074/Jbc.273.42.27331  0.41
1998 Blackburn MR, Datta SK, Kellems RE. Adenosine deaminase-deficient mice generated using a two-stage genetic engineering strategy exhibit a combined immunodeficiency Journal of Biological Chemistry. 273: 5093-5100. PMID 9478961 DOI: 10.1074/Jbc.273.9.5093  0.354
1998 Blackburn MR, Wakamiya M, Kellems RE. Purine metabolic disturbances in adenosine deaminase deficient fetuses and placentae: A protective role for this enzyme during murine development Placenta. 19: 121-135. DOI: 10.1016/S0143-4004(98)80010-6  0.363
1997 Shi D, Winston JH, Blackburn MR, Datta SK, Hanten G, Kellems RE. Diverse genetic regulatory motifs required for murine adenosine deaminase gene expression in the placenta. The Journal of Biological Chemistry. 272: 2334-41. PMID 8999942 DOI: 10.1074/Jbc.272.4.2334  0.447
1996 Winston JH, Hong L, Datta SK, Kellems RE. An intron 1 regulatory region from the murine adenosine deaminase gene can activate heterologous promoters for ubiquitous expression in transgenic mice Somatic Cell and Molecular Genetics. 22: 261-278. PMID 9000171 DOI: 10.1007/Bf02369566  0.446
1996 Lewis AL, Guicherit OM, Datta SK, Hanten GR, Kellems RE. Structure and expression of the murine muscle adenylosuccinate synthetase gene. The Journal of Biological Chemistry. 271: 22647-56. PMID 8798436 DOI: 10.1074/Jbc.271.37.22647  0.319
1996 Blackburn MR, Kellems RE. Regulation and function of adenosine deaminase in mice Progress in Nucleic Acid Research and Molecular Biology. 55: 195-226. PMID 8787611 DOI: 10.1016/S0079-6603(08)60194-4  0.397
1996 Blackburn MR, Datta SK, Wakamiya M, Vartabedian BS, Kellems RE. Metabolic and immunologie consequences of limited adenosine deaminase expression in mice Journal of Biological Chemistry. 271: 15203-15210. PMID 8663040 DOI: 10.1074/Jbc.271.25.15203  0.385
1996 Shi D, Winston J, Blackbum M, Datta S, Kellems R. Diverse genetic regulatory elements are essential for murine adenosine deaminase gene expression in trophoblasts Placenta. 17: A11. DOI: 10.1016/S0143-4004(96)90105-8  0.348
1995 Wakamiya M, Blackburn MR, Jurecic R, McArthur MJ, Geske RS, Cartwright J, Mitani K, Vaishnav S, Belmont JW, Kellems RE, Finegold MJ, Montgomery CA, Bradley A, Caskey CT. Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice Proceedings of the National Academy of Sciences of the United States of America. 92: 3673-3677. PMID 7731963 DOI: 10.1073/Pnas.92.9.3673  0.361
1995 Blackburn MR, Wakamiya M, Caskey CT, Kellems RE. Tissue-specific rescue suggests that placental adenosine deaminase is important for fetal development in mice. The Journal of Biological Chemistry. 270: 23891-4. PMID 7592575 DOI: 10.1074/Jbc.270.41.23891  0.38
1994 Kash SF, Kellems RE. Control of transcription arrest in intron 1 of the murine adenosine deaminase gene Molecular and Cellular Biology. 14: 6198-6207. PMID 8065352 DOI: 10.1128/Mcb.14.9.6198  0.342
1994 Datta SK, Guicherit OM, Kellems RE. Adenylosuccinate synthetase: A dominant amplifiable genetic marker in mammalian cells Somatic Cell and Molecular Genetics. 20: 381-389. PMID 7825060 DOI: 10.1007/Bf02257455  0.339
1994 Winston JH, Hong L, Akroyd S, Hanten G, Waymire K, Overbeek P, Kellems RE. Diverse genetic regulatory elements are required to direct the proper tissue-specific and developmental expression of the murine adenosine deaminase gene. Advances in Experimental Medicine and Biology. 370: 579-84. PMID 7660973 DOI: 10.1007/978-1-4615-2584-4_121  0.429
1993 Kash SF, Innis JW, Jackson AU, Kellems RE. Functional analysis of a stable transcription arrest site in the first intron of the murine adenosine deaminase gene. Molecular and Cellular Biology. 13: 2718-29. PMID 8474437 DOI: 10.1128/Mcb.13.5.2718  0.36
1992 Winston JH, Hanten GR, Overbeek PA, Kellems RE. 5' flanking sequences of the murine adenosine deaminase gene direct expression of a reporter gene to specific prenatal and postnatal tissues in transgenic mice. The Journal of Biological Chemistry. 267: 13472-9. PMID 1618849  0.314
1991 Hong L, Mulholland J, Chinsky JM, Knudsen TB, Kellems RE, Glasser SR. Developmental expression of adenosine deaminase during decidualization in the rat uterus Biology of Reproduction. 44: 83-93. PMID 2015355 DOI: 10.1095/Biolreprod44.1.83  0.393
1991 Chen Z, Innis JW, Sun M, Wright DA, Kellems RE. Sequence Requirements for Transcriptional Arrest in Exon 1 of the Human Adenosine Deaminase Gene Molecular and Cellular Biology. 11: 6248-6256. PMID 1944287 DOI: 10.1128/Mcb.11.12.6248  0.38
1991 Innis JW, Kellems RE. A heat-labile factor promotes premature 3' end formation in exon 1 of the murine adenosine deaminase gene in a cell-free transcription system Molecular and Cellular Biology. 11: 5398-5409. PMID 1717827 DOI: 10.1128/Mcb.11.11.5398  0.336
1991 Kellems RE. Gene amplification in mammalian cells: strategies for protein production Current Opinion in Biotechnology. 2: 723-729. PMID 1367725 DOI: 10.1016/0958-1669(91)90042-4  0.347
1990 al-Ubaidi MR, Ramamurthy V, Maa MC, Ingolia DE, Chinsky JM, Martin BD, Kellems RE. Structural and functional analysis of the murine adenosine deaminase gene. Genomics. 7: 476-85. PMID 2387582 DOI: 10.1016/0888-7543(90)90189-2  0.364
1990 Chinsky JM, Ramamurthy V, Fanslow WC, Ingolia DE, Blackburn MR, Shaffer KT, Higley HR, Trentin JJ, Rudolph FB, Knudsen TB, Kellems RE. Developmental expression of adenosine deaminase in the upper alimentary tract of mice Differentiation. 42: 172-183. PMID 2187728 DOI: 10.1111/J.1432-0436.1990.Tb00759.X  0.345
1990 Chen Z, Harless ML, Wright DA, Kellems RE. Identification and characterization of transcriptional arrest sites in exon 1 of the human adenosine deaminase gene Molecular and Cellular Biology. 10: 4555-4564. PMID 1697031 DOI: 10.1128/Mcb.10.9.4555  0.368
1989 Knudsen TB, Gray MK, Church JK, Blackburn MR, Airhart MJ, Kellems RE, Skalko RG. Early postimplantation embryolethality in mice following in utero inhibition of adenosine deaminase with 2'-deoxycoformycin. Teratology. 40: 615-26. PMID 2623648 DOI: 10.1002/Tera.1420400609  0.341
1989 Stallings RL, Siciliano MJ, Frazier ML, al-Ubaidi MR, Kellems RE. Hypomethylation and ADA gene expression in mouse CAK cells. Somatic Cell and Molecular Genetics. 15: 1-11. PMID 2464855 DOI: 10.1007/BF01534664  0.341
1986 Kaufman RJ, Murtha P, Ingolia DE, Yeung CY, Kellems RE. Selection and amplification of heterologous genes encoding adenosine deaminase in mammalian cells Proceedings of the National Academy of Sciences of the United States of America. 83: 3136-3140. PMID 3486414 DOI: 10.1073/Pnas.83.10.3136  0.335
1986 Belmont JW, Henkel-Tigges J, Chang SM, Wager-Smith K, Kellems RE, Dick JE, Magli MC, Phillips RA, Bernstein A, Caskey CT. Expression of human adenosine deaminase in murine haematopoietic progenitor cells following retroviral transfer. Nature. 322: 385-7. PMID 3016551 DOI: 10.1038/322385A0  0.391
1986 Ingolia DE, Al-Ubaidi MR, Yeung CY, Bigo HA, Wright D, Kellems RE. Molecular cloning of the murine adenosine deaminase gene from a genetically enriched source: identification and characterization of the promoter region. Molecular and Cellular Biology. 6: 4458-66. PMID 2432402 DOI: 10.1128/Mcb.6.12.4458  0.377
1985 Ingolia DE, Yeung C, Shoemaker C, Kaufman RJ, Kellems RE. EXPRESSION OF MURINE ADA CDNA IN E. COLI AND MAMMALIAN CELLS: 90 Pediatric Research. 19: 758-758. DOI: 10.1203/00006450-198507000-00110  0.306
1985 Kellems RE, Yeung CY, Ingolia DE. Adenosine deaminase deficiency and severe combined immunodeficiencies Trends in Genetics. 1: 278-283. DOI: 10.1016/0168-9525(85)90105-2  0.38
1984 Leys EJ, Crouse GF, Kellems RE. Dihydrofolate reductase gene expression in cultured mouse cells is regulated by transcript stabilization in the nucleus Journal of Cell Biology. 99: 180-187. PMID 6736126 DOI: 10.1083/Jcb.99.1.180  0.331
1983 Yoder SS, Robberson BL, Leys EJ, Hook AG, Al-Ubaidi M, Yeung CY, Kellems RE, Berget SM. Control of cellular gene expression during adenovirus infection: induction and shut-off of dihydrofolate reductase gene expression by adenovirus type 2. Molecular and Cellular Biology. 3: 819-28. PMID 6865943 DOI: 10.1128/Mcb.3.5.819  0.336
1978 Schimke RT, Alt FW, Kellems RE, Kaufman RJ, Bertino JR. Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harbor Symposia On Quantitative Biology. 42: 649-57. PMID 277312 DOI: 10.1101/Sqb.1978.042.01.067  0.313
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