Kimberley A. Lentz, Ph.D. - Publications

Affiliations: 
2000 University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Pharmacy, Pharmaceutical Chemistry

30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Kostich W, Hamman BD, Li YW, Naidu S, Dandapani K, Feng J, Easton A, Bourin C, Baker K, Allen J, Savelieva K, Louis JV, Dokania M, Elavazhangan S, Vattikundala P, ... ... Lentz KA, et al. Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain. The Journal of Pharmacology and Experimental Therapeutics. PMID 27411717 DOI: 10.1124/jpet.116.235333  0.64
2016 Toyn JH, Boy KM, Raybon J, Meredith JE, Roberston AS, Guss V, Hoque N, Sweeney F, Zhuo X, Clarke W, Snow K, Denton RR, Zuev D, Thompson LA, Morrison J, ... ... Lentz KA, et al. Robust translation of GSM pharmacology across preclinical species and human subjects. The Journal of Pharmacology and Experimental Therapeutics. PMID 27189974 DOI: 10.1124/jpet.116.232249  0.64
2016 Soares HD, Gasior M, Toyn JH, Wang JS, Hong Q, Berisha F, Furlong MT, Raybon J, Lentz KA, Sweeney F, Zheng N, Akinsanya B, Berman RM, Thompson LA, Olson RE, et al. The Gamma Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and CSF of Healthy Volunteers. The Journal of Pharmacology and Experimental Therapeutics. PMID 27189973 DOI: 10.1124/jpet.116.232256  0.64
2016 Ahuja VT, Hartz RA, Molski TF, Mattson GK, Lentz KA, Grace JE, Lodge NJ, Bronson JJ, Macor JE. Synthesis and evaluation of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 (CRF1) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 27020524 DOI: 10.1016/j.bmcl.2016.03.067  0.64
2015 Shi J, Zuev D, Xu L, Lentz KA, Grace JE, Toyn JH, Olson RE, Macor JE, Thompson LA. Design and optimization of tricyclic gamma-secretase modulators. Bioorganic & Medicinal Chemistry Letters. PMID 26848108 DOI: 10.1016/j.bmcl.2015.06.020  0.64
2015 Boy KM, Guernon JM, Wu YJ, Zhang Y, Shi J, Zhai W, Zhu S, Gerritz SW, Toyn JH, Meredith JE, Barten DM, Burton CR, Albright CF, Good AC, Grace JE, ... Lentz KA, et al. Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE). Bioorganic & Medicinal Chemistry Letters. PMID 26497283 DOI: 10.1016/j.bmcl.2015.10.031  0.64
2014 Toyn JH, Thompson LA, Lentz KA, Meredith JE, Burton CR, Sankaranararyanan S, Guss V, Hall T, Iben LG, Krause CM, Krause R, Lin XA, Pierdomenico M, Polson C, Robertson AS, et al. Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780. International Journal of Alzheimer's Disease. 2014: 431858. PMID 25097793 DOI: 10.1155/2014/431858  0.64
2013 Vivian D, Cheng K, Khurana S, Xu S, Whiterock V, Witter D, Lentz KA, Santone KS, Raufman JP, Polli JE. Design and characterization of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile Acid transporter activity. Pharmaceutical Research. 30: 1240-51. PMID 23319170 DOI: 10.1007/s11095-012-0963-6  0.64
2013 Albright CF, Dockens RC, Meredith JE, Olson RE, Slemmon R, Lentz KA, Wang JS, Denton RR, Pilcher G, Rhyne PW, Raybon JJ, Barten DM, Burton C, Toyn JH, Sankaranarayanan S, et al. Pharmacodynamics of selective inhibition of γ-secretase by avagacestat. The Journal of Pharmacology and Experimental Therapeutics. 344: 686-95. PMID 23275065 DOI: 10.1124/jpet.112.199356  0.64
2012 Luo G, Chen L, Conway CM, Denton R, Keavy D, Gulianello M, Huang Y, Kostich W, Lentz KA, Mercer SE, Schartman R, Signor L, Browning M, Macor JE, Dubowchik GM. Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine. Acs Medicinal Chemistry Letters. 3: 337-41. PMID 24900474 DOI: 10.1021/ml300021s  0.64
2012 Luo G, Chen L, Conway CM, Denton R, Keavy D, Signor L, Kostich W, Lentz KA, Santone KS, Schartman R, Browning M, Tong G, Houston JG, Dubowchik GM, Macor JE. Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine. Journal of Medicinal Chemistry. 55: 10644-51. PMID 23153230 DOI: 10.1021/jm3013147  0.64
2012 Gerritz SW, Zhai W, Shi S, Zhu S, Toyn JH, Meredith JE, Iben LG, Burton CR, Albright CF, Good AC, Tebben AJ, Muckelbauer JK, Camac DM, Metzler W, Cook LS, ... ... Lentz KA, et al. Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis. Journal of Medicinal Chemistry. 55: 9208-23. PMID 23030502 DOI: 10.1021/jm300931y  0.64
2012 Whiterock VJ, Morgan DG, Lentz KA, Orcutt TL, Sinz MW. Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs Drug Metabolism and Disposition. 40: 228-231. PMID 22074769 DOI: 10.1124/dmd.111.041848  0.64
2011 Thompson LA, Shi J, Decicco CP, Tebben AJ, Olson RE, Boy KM, Guernon JM, Good AC, Liauw A, Zheng C, Copeland RA, Combs AP, Trainor GL, Camac DM, Muckelbauer JK, ... Lentz KA, et al. Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 6909-15. PMID 21974952 DOI: 10.1016/j.bmcl.2011.06.116  0.64
2011 Boy KM, Guernon JM, Shi J, Toyn JH, Meredith JE, Barten DM, Burton CR, Albright CF, Marcinkeviciene J, Good AC, Tebben AJ, Muckelbauer JK, Camac DM, Lentz KA, Bronson JJ, et al. Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE). Bioorganic & Medicinal Chemistry Letters. 21: 6916-24. PMID 21782431 DOI: 10.1016/j.bmcl.2011.06.109  0.64
2011 Marcin LR, Higgins MA, Zusi FC, Zhang Y, Dee MF, Parker MF, Muckelbauer JK, Camac DM, Morin PE, Ramamurthy V, Tebben AJ, Lentz KA, Grace JE, Marcinkeviciene JA, Kopcho LM, et al. Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1. Bioorganic & Medicinal Chemistry Letters. 21: 537-41. PMID 21078556 DOI: 10.1016/j.bmcl.2010.10.079  0.64
2010 Gillman KW, Starrett JE, Parker MF, Xie K, Bronson JJ, Marcin LR, McElhone KE, Bergstrom CP, Mate RA, Williams R, Meredith JE, Burton CR, Barten DM, Toyn JH, Roberts SB, ... Lentz KA, et al. Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor. Acs Medicinal Chemistry Letters. 1: 120-4. PMID 24900185 DOI: 10.1021/ml1000239  0.64
2009 Hartz RA, Ahuja VT, Zhuo X, Mattson RJ, Denhart DJ, Deskus JA, Vrudhula VM, Pan S, Ditta JL, Shu YZ, Grace JE, Lentz KA, Lelas S, Li YW, Molski TF, et al. A strategy to minimize reactive metabolite formation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailable corticotropin-releasing factor-1 receptor antagonist. Journal of Medicinal Chemistry. 52: 7653-68. PMID 19954247 DOI: 10.1021/jm900716v  0.64
2009 Hartz RA, Ahuja VT, Arvanitis AG, Rafalski M, Yue EW, Denhart DJ, Schmitz WD, Ditta JL, Deskus JA, Brenner AB, Hobbs FW, Payne J, Lelas S, Li YW, Molski TF, ... ... Lentz KA, et al. Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists. Journal of Medicinal Chemistry. 52: 4173-91. PMID 19552437 DOI: 10.1021/jm900301y  0.64
2009 Hartz RA, Ahuja VT, Rafalski M, Schmitz WD, Brenner AB, Denhart DJ, Ditta JL, Deskus JA, Yue EW, Arvanitis AG, Lelas S, Li YW, Molski TF, Wong H, Grace JE, ... Lentz KA, et al. In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists. Journal of Medicinal Chemistry. 52: 4161-72. PMID 19552436 DOI: 10.1021/jm900302q  0.64
2009 Hartz RA, Ahuja VT, Rafalski M, Schmitz WD, Brenner AB, Denhart DJ, Ditta JL, Deskus JA, Yue EW, Arvanitis AG, Lelas S, Li YW, Molski TF, Wong H, Grace JE, ... Lentz KA, et al. Corrections to in vitro intrinsic clearance-based optimization of N 3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF 1) receptor antagonists (Journal of Medicinal Chemistry (2009) 52, (4161-4172) DOI: 10.1021/jm900302q] Journal of Medicinal Chemistry. 52: 5770. DOI: 10.1021/jm9011033  0.64
2008 Lentz KA. Current methods for predicting human food effect. The Aaps Journal. 10: 282-8. PMID 18500565 DOI: 10.1208/s12248-008-9025-8  0.64
2008 Meredith JE, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, ... ... Lentz KA, et al. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice. The Journal of Pharmacology and Experimental Therapeutics. 326: 502-13. PMID 18499745 DOI: 10.1124/jpet.108.138974  0.64
2007 Lentz KA, Quitko M, Morgan DG, Grace JE, Gleason C, Marathe PH. Development and validation of a preclinical food effect model. Journal of Pharmaceutical Sciences. 96: 459-72. PMID 17075867 DOI: 10.1002/jps.20767  0.64
2006 Gupta E, Barends DM, Yamashita E, Lentz KA, Harmsze AM, Shah VP, Dressman JB, Lipper RA. Review of global regulations concerning biowaivers for immediate release solid oral dosage forms European Journal of Pharmaceutical Sciences. 29: 315-324. PMID 16806858 DOI: 10.1016/j.ejps.2006.05.001  0.64
2005 Rytting E, Lentz KA, Chen XQ, Qian F, Vakatesh S. Aqueous and cosolvent solubility data for drug-like organic compounds. The Aaps Journal. 7: E78-105. PMID 16146352 DOI: 10.1208/aapsj070110  0.64
2004 Tolle-Sander S, Lentz KA, Maeda DY, Coop A, Polli JE. Increased acyclovir oral bioavailability via a bile acid conjugate. Molecular Pharmaceutics. 1: 40-8. PMID 15832499  0.64
2004 Rytting E, Lentz KA, Chen XQ, Qian F, Venkatesh S. A quantitative structure-property relationship for predicting drug solubility in PEG 400/water cosolvent systems. Pharmaceutical Research. 21: 237-44. PMID 15032304 DOI: 10.1023/B:PHAM.0000016237.06815.7a  0.64
2000 Lentz KA, Polli JW, Wring SA, Humphreys JE, Polli JE. Influence of passive permeability on apparent P-glycoprotein kinetics. Pharmaceutical Research. 17: 1456-60. PMID 11303953 DOI: 10.1023/A:1007692622216  0.64
2000 Lentz KA, Hayashi J, Lucisano LJ, Polli JE. Development of a more rapid, reduced serum culture system for Caco-2 monolayers and application to the biopharmaceutics classification system. International Journal of Pharmaceutics. 200: 41-51. PMID 10845684 DOI: 10.1016/S0378-5173(00)00334-3  0.64
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