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Florian L. Muller, Ph.D. - Publications

Affiliations: 
2007 The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States 
Area:
Biochemistry, Molecular Biology, Neuroscience Biology
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Jang YC, Rodriguez K, Lustgarten MS, Muller FL, Bhattacharya A, Pierce A, Choi JJ, Lee NH, Chaudhuri A, Richardson AG, Van Remmen H. Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems. Geroscience. PMID 32451848 DOI: 10.1007/s11357-020-00200-5  0.491
2019 Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R, Han J, Shi X, Seth S, Meyers BA, Miller M, ... ... Muller FL, et al. Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Reports. 26: 469-482.e5. PMID 30625329 DOI: 10.1016/J.Celrep.2018.12.043  0.388
2019 Muller F, Hammoudi N, Lin Y, Satani N. YIA19-004: Collateral Deletion of Glycolysis Genes Generates Selective Vulnerabilities to Inhibitors of Oxidative Phosphorylation Journal of the National Comprehensive Cancer Network. 17. DOI: 10.6004/Jnccn.2018.7219  0.303
2018 Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip AA, Al-Atrash G, Asara J, Bardenhagen J, Carrillo CC, Carroll C, ... ... Muller F, et al. An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nature Medicine. PMID 29892070 DOI: 10.1038/S41591-018-0052-4  0.379
2018 Lissanu Deribe Y, Sun Y, Terranova C, Khan F, Martinez-Ledesma J, Gay J, Gao G, Mullinax RA, Khor T, Feng N, Lin YH, Wu CC, Reyes C, Peng Q, Robinson F, ... ... Muller F, et al. Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer. Nature Medicine. PMID 29892061 DOI: 10.1038/S41591-018-0019-5  0.36
2018 Dey P, Baddour J, Kim Y, Macloed R, Muller F, Wu CC, Wang H, Viale A, Ying H, Draetta G, Maitra A, Wang A, Nagrath D, DePinho R. Abstract 777: Malic enzyme 3 as a collateral lethality target in pancreatic cancer Cancer Research. 78: 777-777. DOI: 10.1158/1538-7445.Am2018-777  0.38
2018 Francesco MED, Marszalek JR, McAfoos T, Carroll CL, Kang Z, Liu G, Theroff JP, Bardenhager JP, Bandi ML, Molina JR, Gera S, Protopopova M, Sun Y, Do MKG, Feng N, ... Muller F, et al. Abstract 1655: Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors Cancer Research. 78: 1655-1655. DOI: 10.1158/1538-7445.Am2018-1655  0.342
2017 Hwang I, Oh H, Santo E, Kim DY, Chen JW, Bronson RT, Locasale JW, Na Y, Lee J, Reed S, Toth M, Yu WH, Muller FL, Paik J. FOXO protects against age-progressive axonal degeneration. Aging Cell. PMID 29178390 DOI: 10.1111/Acel.12701  0.309
2017 Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Wu CC, Seth S, Akdemir KC, Leo E, ... ... Muller F, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. PMID 28178232 DOI: 10.1038/Nature21064  0.334
2017 Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, et al. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. PMID 28099419 DOI: 10.1038/Nature21052  0.379
2017 Lin Y, Satani N, Hammoudi N, Pisaneschi F, Leonard P, Maxwell D, Peng Z, Link T, Gilbert LIR, Bosajou A, Sun D, Marszalek J, Sun Y, McMurray JS, Mandal PK, ... ... Muller F, et al. Abstract A39: Pomhex, a cell-permeable high potency enolase inhibitor with utility for collateral lethality treatment of cancer Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-A39  0.327
2017 Molina J, Bandi M, Bardenhagen J, Bristow C, Carroll C, Chang E, Cross J, Daver N, Feng N, Do MG, Greer J, Han J, Hirst J, Huang S, Jiang Y, ... ... Muller F, et al. Abstract 4971: IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors Cancer Research. 77: 4971-4971. DOI: 10.1158/1538-7445.Am2017-4971  0.367
2016 Satani N, Lin YH, Hammoudi N, Raghavan S, Georgiou DK, Muller FL. ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase. Plos One. 11: e0168739. PMID 28030597 DOI: 10.1371/Journal.Pone.0168739  0.301
2016 Protopopova M, Bandi M, Sun Y, Bardenhagen J, Bristow C, Carroll C, Chang E, Feng N, Do MG, Greer J, Konopleva M, Matre P, Kang Z, Liu G, Muller F, et al. Abstract A65: IACS-10759: A novel OXPHOS inhibitor that selectively kills tumors with metabolic vulnerabilities Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-A65  0.372
2016 Lin Y, Satani N, Hammoudi N, Marszalek J, Sun Y, Protopopova M, Francesco MED, Czako B, Wang A, DePinho RA, Muller FL. Abstract 3837: Passenger deletion of ENO1 as a collateral lethality target in cancer Cancer Research. 76: 3837-3837. DOI: 10.1158/1538-7445.Am2016-3837  0.393
2015 Muller FL, Aquilanti EA, DePinho RA. Collateral Lethality: A new therapeutic strategy in oncology. Trends in Cancer. 1: 161-173. PMID 26870836 DOI: 10.1016/J.Trecan.2015.10.002  0.318
2015 Protopopova M, Bandi M, Bardenhagen J, Bristow C, Carroll C, Chang E, Feng N, Do MG, Greer J, Konopleva M, Matre P, Kang Z, Liu G, Muller F, Lofton T, et al. Abstract 4455: Relapsed/refractory AML responds robustly to IACS-10759, a novel OXPHOS inhibitor Cancer Research. 75: 4455-4455. DOI: 10.1158/1538-7445.Am2015-4455  0.34
2015 Protopopova M, Bandi M, Bardenhagen J, Bristow C, Carroll C, Chang E, Feng N, Do MG, Greer J, Konopleva M, Matre P, Kang Z, Liu G, Muller F, Lofton T, et al. Abstract 4380: IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities Cancer Research. 75: 4380-4380. DOI: 10.1158/1538-7445.Am2015-4380  0.37
2015 Lin Y, Marszalek J, Sun Y, Hammoudi N, Leonard P, Maxwell D, Satani N, Zhang P, Link T, Lee G, Francesco MED, Czako B, Want AY, DePinho RA, Muller FL. Abstract C183: Pomhex: a cell-permeable high potency Enolase inhibitor with in vivo anti-neoplastic activity Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C183  0.366
2014 Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 514: 628-32. PMID 25119024 DOI: 10.1038/Nature13611  0.369
2014 Marszalek JR, Bandi M, Bardenhagen J, Bristow C, Carroll C, Chang E, Feng N, Czako B, Do MG, Greer J, Johnson RM, Konopleva M, Kang Z, Liu G, Lofton T, ... ... Muller F, et al. Abstract 949: Identification of OXPHOS inhibitors which selectively kill tumors with specific metabolic vulnerabilities Cancer Research. 74: 949-949. DOI: 10.1158/1538-7445.Am2014-949  0.386
2014 Verhaak RGW, Kim H, Zheng S, Amini SS, Virk SM, Mikkelsen T, Brat DJ, Grimsby J, Sougnez C, Muller F, Hu J, Sloan AE, Cohen ML, Van Meir EG, Scarpace L, et al. THE P53 PATHWAY AND ANCESTRAL PROGENITORS ARE ASSOCIATED WITH TUMOR RECURRENCE IN GLIOBLASTOMA Neuro-Oncology. 16: iii3-iii3. DOI: 10.1093/Neuonc/Nou206.10  0.301
2013 Malu S, Mbofung R, Khalili J, Satani N, Forget M, Haymaker C, Muller F, Bernatchez C, Radvanyi L, Hwu P. Development of novel combinations of targeted and immunotherapies by understanding immune resistance using a high throughput assay of T cell mediated cytotoxicity Journal For Immunotherapy of Cancer. 1: 164. DOI: 10.1186/2051-1426-1-S1-P164  0.307
2012 Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee MA, Hu B, Hu J, Sahin E, Ong D, et al. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 488: 337-42. PMID 22895339 DOI: 10.1038/Nature11331  0.316
2012 Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H. Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell. 11: 770-82. PMID 22672615 DOI: 10.1111/J.1474-9726.2012.00843.X  0.572
2012 Lustgarten MS, Bhattacharya A, Muller FL, Jang YC, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels. Biochemical and Biophysical Research Communications. 422: 515-21. PMID 22613204 DOI: 10.1016/J.Bbrc.2012.05.055  0.49
2012 Bhattacharya A, Bokov A, Muller FL, Jernigan AL, Maslin K, Diaz V, Richardson A, Van Remmen H. Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS. Neurobiology of Aging. 33: 1829-32. PMID 21763036 DOI: 10.1016/J.Neurobiolaging.2011.06.002  0.674
2011 Lustgarten MS, Jang YC, Liu Y, Qi W, Qin Y, Dahia PL, Shi Y, Bhattacharya A, Muller FL, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging. Aging Cell. 10: 493-505. PMID 21385310 DOI: 10.1111/J.1474-9726.2011.00695.X  0.571
2011 Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, Horner JW, Maratos-Flier E, Depinho RA. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 469: 102-6. PMID 21113150 DOI: 10.1038/Nature09603  0.343
2011 Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, et al. Erratum: Telomere dysfunction induces metabolic and mitochondrial compromise Nature. 475: 254-254. DOI: 10.1038/Nature10223  0.317
2010 Jang YC, Lustgarten MS, Liu Y, Muller FL, Bhattacharya A, Liang H, Salmon AB, Brooks SV, Larkin L, Hayworth CR, Richardson A, Van Remmen H. Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 1376-90. PMID 20040516 DOI: 10.1096/Fj.09-146308  0.669
2009 Lustgarten MS, Jang YC, Liu Y, Muller FL, Qi W, Steinhelper M, Brooks SV, Larkin L, Shimizu T, Shirasawa T, McManus LM, Bhattacharya A, Richardson A, Van Remmen H. Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity. American Journal of Physiology. Cell Physiology. 297: C1520-32. PMID 19776389 DOI: 10.1152/Ajpcell.00372.2009  0.551
2009 Bhattacharya A, Muller FL, Liu Y, Sabia M, Liang H, Song W, Jang YC, Ran Q, Van Remmen H. Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria. The Journal of Biological Chemistry. 284: 46-55. PMID 19001413 DOI: 10.1074/Jbc.M806311200  0.569
2008 Muller FL, Liu Y, Jernigan A, Borchelt D, Richardson A, Van Remmen H. MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models Muscle and Nerve. 38: 1173-1183. PMID 18720509 DOI: 10.1002/Mus.21049  0.533
2008 Pierce A, Mirzaei H, Muller F, De Waal E, Taylor AB, Leonard S, Van Remmen H, Regnier F, Richardson A, Chaudhuri A. GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis. Journal of Molecular Biology. 382: 1195-210. PMID 18706911 DOI: 10.1016/J.Jmb.2008.07.088  0.49
2008 Abdul-Ghani MA, Muller FL, Liu Y, Chavez AO, Balas B, Zuo P, Chang Z, Tripathy D, Jani R, Molina-Carrion M, Monroy A, Folli F, Van Remmen H, DeFronzo RA. Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance. American Journal of Physiology. Endocrinology and Metabolism. 295: E678-85. PMID 18593850 DOI: 10.1152/Ajpendo.90287.2008  0.302
2008 Han ES, Muller FL, Pérez VI, Qi W, Liang H, Xi L, Fu C, Doyle E, Hickey M, Cornell J, Epstein CJ, Roberts LJ, Van Remmen H, Richardson A. The in vivo gene expression signature of oxidative stress. Physiological Genomics. 34: 112-26. PMID 18445702 DOI: 10.1152/Physiolgenomics.00239.2007  0.642
2007 Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Trends in oxidative aging theories. Free Radical Biology & Medicine. 43: 477-503. PMID 17640558 DOI: 10.1016/J.Freeradbiomed.2007.03.034  0.505
2007 Muller FL, Song W, Jang YC, Liu Y, Sabia M, Richardson A, Van Remmen H. Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 293: R1159-68. PMID 17584954 DOI: 10.1152/Ajpregu.00767.2006  0.545
2006 Muller FL, Song W, Liu Y, Chaudhuri A, Pieke-Dahl S, Strong R, Huang TT, Epstein CJ, Roberts LJ, Csete M, Faulkner JA, Van Remmen H. Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radical Biology & Medicine. 40: 1993-2004. PMID 16716900 DOI: 10.1016/J.Freeradbiomed.2006.01.036  0.39
2006 Mansouri A, Muller FL, Liu Y, Ng R, Faulkner J, Hamilton M, Richardson A, Huang TT, Epstein CJ, Van Remmen H. Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging. Mechanisms of Ageing and Development. 127: 298-306. PMID 16405961 DOI: 10.1016/J.Mad.2005.11.004  0.569
2004 Muller FL, Liu Y, Van Remmen H. Complex III releases superoxide to both sides of the inner mitochondrial membrane. The Journal of Biological Chemistry. 279: 49064-73. PMID 15317809 DOI: 10.1074/Jbc.M407715200  0.326
2000 Muller F. The nature and mechanism of superoxide production by the electron transport chain: Its relevance to aging Age. 23: 227-253. PMID 23604868 DOI: 10.1007/S11357-000-0022-9  0.336
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