Kevin Janes, Ph.D. - Publications

Affiliations: 
Biomedical Engineering University of Virginia, Charlottesville, VA 

37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Przanowska RK, Labban N, Przanowski P, Hawes RB, Atkins KA, Showalter SL, Janes KA. Patient-derived response estimates from zero-passage organoids of luminal breast cancer. Biorxiv : the Preprint Server For Biology. PMID 38585922 DOI: 10.1101/2024.03.24.586432  0.745
2024 Griffiths CD, Shah M, Shao W, Borgman CA, Janes KA. Three Modes of Viral Adaption by the Heart. Biorxiv : the Preprint Server For Biology. PMID 38585853 DOI: 10.1101/2024.03.28.587274  0.547
2022 Przanowska RK, Weidmann CA, Saha S, Cichewicz MA, Jensen KN, Przanowski P, Irving PS, Janes KA, Guertin MJ, Weeks KM, Dutta A. Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors. Cell Reports. 38: 110361. PMID 35172143 DOI: 10.1016/j.celrep.2022.110361  0.732
2021 Lopacinski AB, Sweatt AJ, Smolko CM, Gray-Gaillard E, Borgman CA, Shah M, Janes KA. Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback. Cell Systems. PMID 33740397 DOI: 10.1016/j.cels.2021.02.004  0.583
2021 Singh S, Sutcliffe MD, Repich K, Atkins KA, Harvey JA, Janes KA. Pan-cancer Drivers are Recurrent Transcriptional Regulatory Heterogeneities in Early-stage Luminal Breast Cancer. Cancer Research. PMID 33531373 DOI: 10.1158/0008-5472.CAN-20-1034  0.327
2018 Borten MA, Bajikar SS, Sasaki N, Clevers H, Janes KA. Automated brightfield morphometry of 3D organoid populations by OrganoSeg. Scientific Reports. 8: 5319. PMID 29593296 DOI: 10.1038/S41598-017-18815-8  0.744
2017 Bajikar SS, Wang CC, Borten MA, Pereira EJ, Atkins KA, Janes KA. Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer. Developmental Cell. 43: 418-435.e13. PMID 29161592 DOI: 10.1016/J.Devcel.2017.10.027  0.748
2017 Janes KA, Chandran PL, Ford RM, Lazzara MJ, Papin JA, Peirce SM, Saucerman JJ, Lauffenburger DA. An engineering design approach to systems biology. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28590470 DOI: 10.1039/C7Ib00014F  0.552
2017 Shah M, Smolko CM, Kinicki S, Chapman ZD, Brautigan DL, Janes KA. Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes. Molecular & Cellular Proteomics : McP. PMID 28174228 DOI: 10.1074/Mcp.O116.063487  0.618
2017 Pereira E, Janes K. Abstract 3954: Single-cell misregulation of NRF2 in basal-like breast cancer Cancer Research. 77: 3954-3954. DOI: 10.1158/1538-7445.Am2017-3954  0.469
2016 Chitforoushzadeh Z, Ye Z, Sheng Z, LaRue S, Fry RC, Lauffenburger DA, Janes KA. TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors. Science Signaling. 9: ra59. PMID 27273097 DOI: 10.1126/Scisignal.Aad3373  0.647
2016 Janes KA, VanHook AM. Science Signaling Podcast for 7 June 2016: Modeling signal integration. Science Signaling. 9: pc13. PMID 27273095 DOI: 10.1126/Scisignal.Aag1902  0.351
2016 Jensen KJ, Moyer CB, Janes KA. Network Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting. Cell Systems. 2: 112-121. PMID 26942229 DOI: 10.1016/j.cels.2016.01.012  0.568
2014 Wang CC, Janes KA. Non-genetic heterogeneity caused by differential single-cell adhesion. Cell Cycle (Georgetown, Tex.). 13: 2149-50. PMID 24956151 DOI: 10.4161/Cc.29660  0.334
2014 Wang CC, Bajikar SS, Jamal L, Atkins KA, Janes KA. A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies. Nature Cell Biology. 16: 345-56. PMID 24658685 DOI: 10.1038/Ncb2930  0.758
2014 Bajikar SS, Fuchs C, Roller A, Theis FJ, Janes KA. Parameterizing cell-to-cell regulatory heterogeneities via stochastic transcriptional profiles. Proceedings of the National Academy of Sciences of the United States of America. 111: E626-35. PMID 24449900 DOI: 10.1073/pnas.1311647111  0.76
2013 Kang BH, Jensen KJ, Hatch JA, Janes KA. Simultaneous profiling of 194 distinct receptor transcripts in human cells. Science Signaling. 6: rs13. PMID 23921087 DOI: 10.1126/scisignal.2003624  0.616
2013 Janes KA, Lauffenburger DA. Models of signalling networks - what cell biologists can gain from them and give to them. Journal of Cell Science. 126: 1913-21. PMID 23720376 DOI: 10.1242/jcs.112045  0.476
2013 Jensen KJ, Garmaroudi FS, Zhang J, Lin J, Boroomand S, Zhang M, Luo Z, Yang D, Luo H, McManus BM, Janes KA. An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection. Cell Host & Microbe. 13: 67-76. PMID 23332156 DOI: 10.1016/J.Chom.2012.11.009  0.612
2012 Jensen KJ, Janes KA. Modeling the latent dimensions of multivariate signaling datasets. Physical Biology. 9: 045004. PMID 22871687 DOI: 10.1088/1478-3975/9/4/045004  0.646
2012 Bajikar SS, Janes KA. Multiscale models of cell signaling. Annals of Biomedical Engineering. 40: 2319-27. PMID 22476894 DOI: 10.1007/s10439-012-0560-1  0.77
2012 Wang L, Janes K. Abstract 1082: Stochastic control of abnormal morphogenesis induced by the ErbB2 oncoprotein Cancer Research. 72: 1082-1082. DOI: 10.1158/1538-7445.Am2012-1082  0.422
2011 Wang L, Brugge JS, Janes KA. Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 108: E803-12. PMID 21873240 DOI: 10.1073/Pnas.1103423108  0.371
2011 Janes K, Wang C, Jamal L, Bajikar S, Atkins K. Abstract SY17-01: Heterogeneous single-cell expression programs and basal-like breast cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Sy17-01  0.79
2010 Janes KA, Wang CC, Holmberg KJ, Cabral K, Brugge JS. Identifying single-cell molecular programs by stochastic profiling. Nature Methods. 7: 311-7. PMID 20228812 DOI: 10.1038/Nmeth.1442  0.34
2008 Janes KA, Reinhardt HC, Yaffe MB. Cytokine-induced signaling networks prioritize dynamic range over signal strength. Cell. 135: 343-54. PMID 18957207 DOI: 10.1016/J.Cell.2008.08.034  0.307
2007 Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA. Common effector processing mediates cell-specific responses to stimuli. Nature. 448: 604-8. PMID 17637676 DOI: 10.1038/Nature06001  0.541
2006 Miller-Jensen K, Janes KA, Wong YL, Griffith LG, Lauffenburger DA. Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis. Journal of Cell Science. 119: 3788-98. PMID 16940353 DOI: 10.1242/Jcs.03102  0.522
2006 Kumar N, Hendriks BS, Janes KA, de Graaf D, Lauffenburger DA. Applying computational modeling to drug discovery and development. Drug Discovery Today. 11: 806-11. PMID 16935748 DOI: 10.1016/j.drudis.2006.07.010  0.415
2006 Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell. 124: 1225-39. PMID 16564013 DOI: 10.1016/j.cell.2006.01.041  0.448
2006 Janes KA, Lauffenburger DA. A biological approach to computational models of proteomic networks. Current Opinion in Chemical Biology. 10: 73-80. PMID 16406679 DOI: 10.1016/j.cbpa.2005.12.016  0.418
2005 Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science (New York, N.Y.). 310: 1646-53. PMID 16339439 DOI: 10.1126/Science.1116598  0.529
2005 Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK. A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Molecular & Cellular Proteomics : McP. 4: 1569-90. PMID 16030008 DOI: 10.1074/mcp.M500158-MCP200  0.557
2005 Shults MD, Janes KA, Lauffenburger DA, Imperiali B. A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates. Nature Methods. 2: 277-83. PMID 15782220 DOI: 10.1038/Nmeth747  0.399
2004 Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA. Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 11: 544-61. PMID 15579231 DOI: 10.1089/1066527041887258  0.545
2004 Janes KA, Albeck JG, Gaudet S, Nielsen UB, Sorger PK, Lauffenburger DA, Yaffe MB. MULTIVARIATE APPROACHES FOR REVEALING BIOLOGICAL SIGNAL-RESPONSE RELATIONSHIPS RELEVANT TO SEPSIS Shock. 21: 3. DOI: 10.1097/00024382-200403001-00009  0.437
2003 Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Molecular & Cellular Proteomics : McP. 2: 463-73. PMID 12832460 DOI: 10.1074/Mcp.M300045-Mcp200  0.508
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