Brian P. Sorrentino - Publications

Molecular Therapeutics and Cell Signaling University of Tennessee Health Science Center, Memphis, TN, United States 
Molecular Biology, Immunology, Epidemiology, Oncology

92 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mamcarz E, Zhou S, Lockey T, Abdelsamed H, Cross SJ, Kang G, Ma Z, Condori J, Dowdy J, Triplett B, Li C, Maron G, Aldave Becerra JC, Church JA, Dokmeci E, ... ... Sorrentino BP, et al. Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1. The New England Journal of Medicine. 380: 1525-1534. PMID 30995372 DOI: 10.1056/NEJMoa1815408  0.68
2018 Fatima S, Zhou S, Sorrentino BP. Marking of definitive HSC precursors in E7.5-E8.5 embryos using an Abcg2-CreER lineage tracing mouse model. Experimental Hematology. PMID 29964089 DOI: 10.1016/j.exphem.2018.06.286  0.68
2016 De Ravin SS, Wu X, Moir S, Anaya-O'Brien S, Kwatemaa N, Littel P, Theobald N, Choi U, Su L, Marquesen M, Hilligoss D, Lee J, Buckner CM, Zarember KA, O'Connor G, ... ... Sorrentino BP, et al. Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency. Science Translational Medicine. 8: 335ra57. PMID 27099176 DOI: 10.1126/scitranslmed.aad8856  0.68
2016 Zhou S, Fatima S, Ma Z, Wang YD, Lu T, Janke LJ, Du Y, Sorrentino BP. Evaluating the safety of retroviral vectors based on insertional oncogene activation and blocked differentiation in cultured thymocytes. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26957223 DOI: 10.1038/mt.2016.55  0.68
2015 Morfouace M, Cheepala S, Jackson S, Fukuda Y, Patel YT, Fatima S, Kawauchi D, Shelat AA, Stewart CF, Sorrentino BP, Schuetz JD, Roussel MF. ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy. Cancer Research. PMID 26199091 DOI: 10.1158/0008-5472.CAN-15-0030  0.4
2015 Zhou S, Bonner MA, Wang YD, Rapp S, De Ravin SS, Malech HL, Sorrentino BP. Quantitative shearing linear amplification polymerase chain reaction: an improved method for quantifying lentiviral vector insertion sites in transplanted hematopoietic cell systems. Human Gene Therapy Methods. 26: 4-12. PMID 25545666 DOI: 10.1089/hgtb.2014.122  0.68
2014 Yu H, Neale G, Zhang H, Lee HM, Ma Z, Zhou S, Forget BG, Sorrentino BP. Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo. Blood. 124: 1737-47. PMID 25082879 DOI: 10.1182/blood-2013-10-534735  0.68
2014 Maher TJ, Ren Y, Li Q, Braunlin E, Garry MG, Sorrentino BP, Martin CM. ATP-binding cassette transporter Abcg2 lineage contributes to the cardiac vasculature after oxidative stress. American Journal of Physiology. Heart and Circulatory Physiology. 306: H1610-8. PMID 24727496 DOI: 10.1152/ajpheart.00638.2013  0.68
2014 Treanor LM, Zhou S, Janke L, Churchman ML, Ma Z, Lu T, Chen SC, Mullighan CG, Sorrentino BP. Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential. The Journal of Experimental Medicine. 211: 701-13. PMID 24687960 DOI: 10.1084/jem.20122727  0.68
2014 De Ravin SS, Gray JT, Throm RE, Spindler J, Kearney M, Wu X, Coffin JM, Hughes SH, Malderelli F, Sorrentino BP, Malech HL. False-positive HIV PCR test following ex vivo lentiviral gene transfer treatment of X-linked severe combined immunodeficiency vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 244-5. PMID 24487563 DOI: 10.1038/mt.2013.296  0.68
2013 Koldej RM, Carney G, Wielgosz MM, Zhou S, Zhan J, Sorrentino BP, Nienhuis AW. Comparison of insulators and promoters for expression of the Wiskott-Aldrich syndrome protein using lentiviral vectors. Human Gene Therapy. Clinical Development. 24: 77-85. PMID 23786330 DOI: 10.1089/humc.2012.244  0.68
2013 Zhou S, Ma Z, Lu T, Janke L, Gray JT, Sorrentino BP. Mouse transplant models for evaluating the oncogenic risk of a self-inactivating XSCID lentiviral vector. Plos One. 8: e62333. PMID 23626802 DOI: 10.1371/journal.pone.0062333  0.68
2013 Yasuda K, Cline C, Vogel P, Onciu M, Fatima S, Sorrentino BP, Thirumaran RK, Ekins S, Urade Y, Fujimori K, Schuetz EG. Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 923-31. PMID 23298861 DOI: 10.1124/dmd.112.050344  0.68
2012 Greene MR, Lockey T, Mehta PK, Kim YS, Eldridge PW, Gray JT, Sorrentino BP. Transduction of human CD34+ repopulating cells with a self-inactivating lentiviral vector for SCID-X1 produced at clinical scale by a stable cell line. Human Gene Therapy Methods. 23: 297-308. PMID 23075105 DOI: 10.1089/hgtb.2012.150  0.68
2012 Sorrentino BP. Chemoprotection in brain tumor patients: another success for stem cell gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1485-7. PMID 22850719 DOI: 10.1038/mt.2012.139  0.68
2012 Corrigan-Curay J, Cohen-Haguenauer O, O'Reilly M, Ross SR, Fan H, Rosenberg N, Somia N, King N, Friedmann T, Dunbar C, Aiuti A, Naldini L, Baum C, von Kalle C, Kiem HP, ... ... Sorrentino BP, et al. Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1084-94. PMID 22652996 DOI: 10.1038/mt.2012.93  0.68
2012 Fatima S, Zhou S, Sorrentino BP. Abcg2 expression marks tissue-specific stem cells in multiple organs in a mouse progeny tracking model. Stem Cells (Dayton, Ohio). 30: 210-21. PMID 22134889 DOI: 10.1002/stem.1002  0.68
2012 Telbisz Á, Hegedüs C, Özvegy-Laczka C, Goda K, Várady G, Takáts Z, Szabó E, Sorrentino BP, Váradi A, Sarkadi B. Antibody binding shift assay for rapid screening of drug interactions with the human ABCG2 multidrug transporter. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 45: 101-9. PMID 22115866 DOI: 10.1016/j.ejps.2011.10.021  0.68
2011 Doyle MJ, Zhou S, Tanaka KK, Pisconti A, Farina NH, Sorrentino BP, Olwin BB. Abcg2 labels multiple cell types in skeletal muscle and participates in muscle regeneration. The Journal of Cell Biology. 195: 147-63. PMID 21949413 DOI: 10.1083/jcb.201103159  0.68
2011 Campbell PK, Zong Y, Yang S, Zhou S, Rubnitz JE, Sorrentino BP. Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemia. Leukemia Research. 35: 1321-9. PMID 21640380 DOI: 10.1016/j.leukres.2011.05.004  0.68
2011 Treanor LM, Volanakis EJ, Zhou S, Lu T, Sherr CJ, Sorrentino BP. Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies. Blood. 117: 5453-62. PMID 21427293 DOI: 10.1182/blood-2010-09-309831  0.68
2010 Zhou S, Mody D, DeRavin SS, Hauer J, Lu T, Ma Z, Hacein-Bey Abina S, Gray JT, Greene MR, Cavazzana-Calvo M, Malech HL, Sorrentino BP. A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells. Blood. 116: 900-8. PMID 20457870 DOI: 10.1182/blood-2009-10-250209  0.68
2010 Jiang J, Yu H, Shou Y, Neale G, Zhou S, Lu T, Sorrentino BP. Hemgn is a direct transcriptional target of HOXB4 and induces expansion of murine myeloid progenitor cells. Blood. 116: 711-9. PMID 20393131 DOI: 10.1182/blood-2009-07-235341  0.68
2010 Sorrentino BP. Scl and stem cell quiescence. Blood. 115: 751-2. PMID 20110428 DOI: 10.1182/blood-2009-11-251264  0.68
2009 Larochelle A, Choi U, Shou Y, Naumann N, Loktionova NA, Clevenger JR, Krouse A, Metzger M, Donahue RE, Kang E, Stewart C, Persons D, Malech HL, Dunbar CE, Sorrentino BP. In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene. The Journal of Clinical Investigation. 119: 1952-63. PMID 19509470 DOI: 10.1172/JCI37506  0.68
2009 Cicero SA, Johnson D, Reyntjens S, Frase S, Connell S, Chow LM, Baker SJ, Sorrentino BP, Dyer MA. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 6685-90. PMID 19346468 DOI: 10.1073/pnas.0901596106  0.68
2009 Throm RE, Ouma AA, Zhou S, Chandrasekaran A, Lockey T, Greene M, De Ravin SS, Moayeri M, Malech HL, Sorrentino BP, Gray JT. Efficient construction of producer cell lines for a SIN lentiviral vector for SCID-X1 gene therapy by concatemeric array transfection. Blood. 113: 5104-10. PMID 19286997 DOI: 10.1182/blood-2008-11-191049  0.68
2009 Persons DA, Sorrentino BP, Nienhuis AW. Prospects for gene therapy of sickle cell disease and thalassemia Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management, Second Edition. 791-814. DOI: 10.1017/CBO9780511596582.044  0.68
2008 Ozvegy-Laczka C, Laczkó R, Hegedus C, Litman T, Várady G, Goda K, Hegedus T, Dokholyan NV, Sorrentino BP, Váradi A, Sarkadi B. Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter. The Journal of Biological Chemistry. 283: 26059-70. PMID 18644784 DOI: 10.1074/jbc.M803230200  0.68
2007 Will E, Bailey J, Schuesler T, Modlich U, Balcik B, Burzynski B, Witte D, Layh-Schmitt G, Rudolph C, Schlegelberger B, von Kalle C, Baum C, Sorrentino BP, Wagner LM, Kelly P, et al. Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 782-91. PMID 17299409 DOI: 10.1038/  0.68
2007 Zong Y, Zhou S, Sorrentino BP. Reply to 'Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels' by Widmer et al. [2] Leukemia. 21: 1562-1563. DOI: 10.1038/sj.leu.2404672  0.68
2006 Husain SM, Shou Y, Sorrentino BP, Handgretinger R. Isolation, molecular cloning and in vitro expression of rhesus monkey (Macaca mulatta) prominin-1.s1 complementary DNA encoding a potential hematopoietic stem cell antigen. Tissue Antigens. 68: 317-24. PMID 17026467 DOI: 10.1111/j.1399-0039.2006.00679.x  0.68
2006 Zong Y, Zhou S, Fatima S, Sorrentino BP. Expression of mouse Abcg2 mRNA during hematopoiesis is regulated by alternative use of multiple leader exons and promoters. The Journal of Biological Chemistry. 281: 29625-32. PMID 16885162 DOI: 10.1074/jbc.M606314200  0.68
2006 Shou Y, Ma Z, Lu T, Sorrentino BP. Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy. Proceedings of the National Academy of Sciences of the United States of America. 103: 11730-5. PMID 16864781 DOI: 10.1073/pnas.0603635103  0.68
2006 Nienhuis AW, Dunbar CE, Sorrentino BP. Genotoxicity of retroviral integration in hematopoietic cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 1031-49. PMID 16624621 DOI: 10.1016/j.ymthe.2006.03.001  0.68
2006 Tadjali M, Zhou S, Rehg J, Sorrentino BP. Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele. Stem Cells (Dayton, Ohio). 24: 1556-63. PMID 16484343 DOI: 10.1634/stemcells.2005-0562  0.68
2006 Seggewiss R, Pittaluga S, Adler RL, Guenaga FJ, Ferguson C, Pilz IH, Ryu B, Sorrentino BP, Young WS, Donahue RE, von Kalle C, Nienhuis AW, Dunbar CE. Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque. Blood. 107: 3865-7. PMID 16439674 DOI: 10.1182/blood-2005-10-4108  0.68
2006 Zong Y, Zhou S, Sorrentino BP. Reply to Rumpold et al. Leukemia. 20: 144-145. PMID 16270041 DOI: 10.1038/sj.leu.2404002  0.68
2005 Zong Y, Zhou S, Sorrentino BP. Loss of P-glycoprotein expression in hematopoietic stem cells does not improve responses to imatinib in a murine model of chronic myelogenous leukemia. Leukemia. 19: 1590-6. PMID 16001089 DOI: 10.1038/sj.leu.2403853  0.68
2005 Stepanova L, Sorrentino BP. A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress. Blood. 106: 827-32. PMID 15692066 DOI: 10.1182/blood-2004-06-2242  0.68
2005 Ozvegy-Laczka C, Várady G, Köblös G, Ujhelly O, Cervenak J, Schuetz JD, Sorrentino BP, Koomen GJ, Váradi A, Német K, Sarkadi B. Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface. The Journal of Biological Chemistry. 280: 4219-27. PMID 15557326 DOI: 10.1074/jbc.M411338200  0.68
2005 Zhou S, Zong Y, Ney PA, Nair G, Stewart CF, Sorrentino BP. Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels. Blood. 105: 2571-6. PMID 15546952 DOI: 10.1182/blood-2004-04-1566  0.68
2005 Sorrentino BP. Improved human stem-cell transaction: The cat's meow Blood. 106: 8. DOI: 10.1182/blood-2005-04-1498  0.68
2004 Sorrentino BP. Clinical strategies for expansion of haematopoietic stem cells. Nature Reviews. Immunology. 4: 878-88. PMID 15516967 DOI: 10.1038/nri1487  0.68
2004 Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE, Sarkadi B, Sorrentino BP, Schuetz JD. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. The Journal of Biological Chemistry. 279: 24218-25. PMID 15044468 DOI: 10.1074/jbc.M313599200  0.68
2004 Persons DA, Allay JA, Bonifacino A, Lu T, Agricola B, Metzger ME, Donahue RE, Dunbar CE, Sorrentino BP. Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors. Blood. 103: 796-803. PMID 12920024 DOI: 10.1182/blood-2003-05-1572  0.68
2003 Zhou S, Zong Y, Lu T, Sorrentino BP. Hematopoietic cells from mice that are deficient in both Bcrp1/Abcg2 and Mdr1a/1b develop normally but are sensitized to mitoxantrone. Biotechniques. 35: 1248-52. PMID 14682060  0.68
2003 Sawai N, Persons DA, Zhou S, Lu T, Sorrentino BP. Reduction in hematopoietic stem cell numbers with in vivo drug selection can be partially abrogated by HOXB4 gene expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 376-84. PMID 12946310 DOI: 10.1016/S1525-0016(03)00205-3  0.68
2003 Nienhuis AW, Hanawa H, Sawai N, Sorrentino BP, Persons DA. Development of gene therapy for hemoglobin disorders. Annals of the New York Academy of Sciences. 996: 101-11. PMID 12799288  0.68
2003 Persons DA, Allay ER, Sawai N, Hargrove PW, Brent TP, Hanawa H, Nienhuis AW, Sorrentino BP. Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells. Blood. 102: 506-13. PMID 12663444 DOI: 10.1182/blood-2003-03-0677  0.68
2002 Abbott BL, Colapietro AM, Barnes Y, Marini F, Andreeff M, Sorrentino BP. Low levels of ABCG2 expression in adult AML blast samples. Blood. 100: 4594-601. PMID 12393637 DOI: 10.1182/blood-2002-01-0271  0.68
2002 Zhou S, Morris JJ, Barnes Y, Lan L, Schuetz JD, Sorrentino BP. Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 99: 12339-44. PMID 12218177 DOI: 10.1073/pnas.192276999  0.68
2002 Sorrentino BP. Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs. Nature Reviews. Cancer. 2: 431-41. PMID 12189385 DOI: 10.1038/nrc823  0.68
2002 Bunting KD, Bradley HL, Hawley TS, Moriggl R, Sorrentino BP, Ihle JN. Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood. 99: 479-87. PMID 11781228 DOI: 10.1182/blood.V99.2.479  0.68
2001 Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nature Medicine. 7: 1028-34. PMID 11533706 DOI: 10.1038/nm0901-1028  0.68
2001 Donahue RE, Sorrentino BP, Hawley RG, An DS, Chen ISY, Wersto RP. Fibronectin fragment CH-296 inhibits apoptosis and enhances ex vivo gene transfer by murine retrovirus and human lentivirus vectors independent of viral tropism in nonhuman primate CD34+ cells Molecular Therapy. 3: 359-367. PMID 11273778 DOI: 10.1006/mthe.2001.0269  0.68
2001 Sellers SE, Tisdale JF, Agricola BA, Metzger ME, Donahue RE, Dunbar CE, Sorrentino BP. The effect of multidrug-resistance 1 gene versus neo transduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells. Blood. 97: 1888-91. PMID 11238136 DOI: 10.1182/blood.V97.6.1888  0.68
2001 Sawai N, Zhou S, Vanin EF, Houghton P, Brent TP, Sorrentino BP. Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector Molecular Therapy. 3: 78-87. PMID 11162314 DOI: 10.1006/mthe.2000.0223  0.68
2000 Bunting KD, Zhou S, Lu T, Sorrentino BP. Enforced P-glycoprotein pump function in murine bone marrow cells results in expression of side population stem cells in vitro and repopulating cells in vivo Blood. 96: 902-909. PMID 10910903  0.68
2000 Giorgianni F, Bridson PK, Sorrentino BP, Pohl J, Blakley RL. Inactivation of aldophosphamide by human aldehyde dehydrogenase isozyme 3. Biochemical Pharmacology. 60: 325-38. PMID 10856427 DOI: 10.1016/S0006-2952(00)00344-0  0.68
2000 Patel DH, Allay JA, Belt JA, Sorrentino BP. Retroviral transfer of the hENT2 nucleoside transporter cDNA confers broad-spectrum antifolate resistance in murine bone marrow cells Blood. 95: 2356-2363. PMID 10733507  0.68
2000 Donahue RE, Wersto RP, Allay JA, Agricola BA, Metzger ME, Nienhuis AW, Persons DA, Sorrentino BP. High levels of lymphoid expression of enhanced green fluorescent protein in nonhuman primates transplanted with cytokine-mobilized peripheral blood CD34(+) cells. Blood. 95: 445-52. PMID 10627448  0.68
2000 Bunting KD, Lu T, Kelly PF, Sorrentino BP. Self-selection by genetically modified committed lymphocyte precursors reverses the phenotype of JAK3-deficient mice without myeloablation Human Gene Therapy. 11: 2353-2364. DOI: 10.1089/104303400750038462  0.68
1999 Sorrentino BP, Allay JA, Blakley RL. In vivo selection of hematopoietic stem cells transduced with DHFR-expressing retroviral vectors. Progress in Experimental Tumor Research. 36: 143-61. PMID 10386071  0.68
1999 Bunting KD, Galipeau J, Topham D, Benaim E, Sorrentino BP. Effects of retroviral-mediated MDR1 expression on hematopoietic stem cell self-renewal and differentiation in culture Annals of the New York Academy of Sciences. 872: 125-141. PMID 10372117 DOI: 10.1111/j.1749-6632.1999.tb08459.x  0.68
1999 Bunting KD, Flynn KJ, Riberdy JM, Doherty PC, Sorrentino BP. Virus-specific immunity after gene therapy in a murine model of severe combined immunodeficiency Proceedings of the National Academy of Sciences of the United States of America. 96: 232-237. PMID 9874801 DOI: 10.1073/pnas.96.1.232  0.68
1998 Allay JA, Galipeau J, Blakley RL, Sorrentino BP. Retroviral vectors containing a variant dihydrofolate reductase gene for drug protection and in vivo selection of hematopoietic cells. Stem Cells (Dayton, Ohio). 16: 223-33. PMID 11012166 DOI: 10.1002/stem.5530160827  0.68
1998 Persons DA, Allay JA, Riberdy JM, Wersto RP, Donahue RE, Sorrentino BP, Nienhuis AW. Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells. Nature Medicine. 4: 1201-5. PMID 9771757 DOI: 10.1038/2704  0.68
1998 Allay JA, Persons DA, Galipeau J, Riberdy JM, Ashmun RA, Blakley RL, Sorrentino BP. In vivo selection of retrovirally transduced hematopoietic stem cells. Nature Medicine. 4: 1136-43. PMID 9771746 DOI: 10.1038/2632  0.68
1998 Bunting KD, Galipeau J, Topham D, Benaim E, Sorrentino BP. Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice Blood. 92: 2269-2279. PMID 9746764  0.68
1998 Mareya SM, Sorrentino BP, Blakley RL. Protection of CCRF-CEM human lymphoid cells from antifolates by retroviral gene transfer of variants of murine dihydrofolate reductase. Cancer Gene Therapy. 5: 225-35. PMID 9694074  0.68
1998 Blakley RL, Sorrentino BP. In vitro mutations in dihydrofolate reductase that confer resistance to methotrexate: potential for clinical application. Human Mutation. 11: 259-63. PMID 9554740 DOI: 10.1002/(SICI)1098-1004(1998)11:4<259::AID-HUMU1>3.0.CO;2-W  0.68
1998 Bunting KD, Sangster MY, Ihle JN, Sorrentino BP. Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer. Nature Medicine. 4: 58-64. PMID 9427607 DOI: 10.1038/nm0198-058  0.68
1997 Patel M, Sleep SE, Lewis WS, Spencer HT, Mareya SM, Sorrentino BP, Blakley RL. Comparison of the protection of cells from antifolates by transduced human dihydrofolate reductase mutants. Human Gene Therapy. 8: 2069-77. PMID 9414255 DOI: 10.1089/hum.1997.8.17-2069  0.68
1997 Galipeau J, Benaim E, Spencer HT, Blakley RL, Sorrentino BP. A bicistronic retroviral vector for protecting hematopoietic cells against antifolates and P-glycoprotein effluxed drugs. Human Gene Therapy. 8: 1773-83. PMID 9358027 DOI: 10.1089/hum.1997.8.15-1773  0.68
1997 Allay JA, Spencer HT, Wilkinson SL, Belt JA, Blakley RL, Sorrentino BP. Sensitization of hematopoietic stem and progenitor cells to trimetrexate using nucleoside transport inhibitors. Blood. 90: 3546-54. PMID 9345038  0.68
1997 Bunting KD, Webb M, Giorgianni F, Galipeau J, Blakley RL, Townsend AJ, Sorrentino BP. Coding region-specific destabilization of mRNA transcripts attenuates expression from retroviral vectors containing class 1 aldehyde dehydrogenase cDNAs. Human Gene Therapy. 8: 1531-43. PMID 9322086 DOI: 10.1089/hum.1997.8.13-1531  0.68
1997 Persons DA, Allay JA, Allay ER, Smeyne RJ, Ashmun RA, Sorrentino BP, Nienhuis AW. Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo. Blood. 90: 1777-86. PMID 9292510  0.68
1996 Benaim E, Sorrentino BP. Gene therapy in pediatric oncology Investigational New Drugs. 14: 87-99. PMID 8880396  0.68
1996 Spencer HT, Sorrentino BP, Pui CH, Chunduru SK, Sleep SE, Blakley RL. Mutations in the gene for human dihydrofolate reductase: an unlikely cause of clinical relapse in pediatric leukemia after therapy with methotrexate. Leukemia. 10: 439-46. PMID 8642859  0.68
1996 Spencer HT, Sleep SE, Rehg JE, Blakley RL, Sorrentino BP. A gene transfer strategy for making bone marrow cells resistant to trimetrexate. Blood. 87: 2579-87. PMID 8630426  0.68
1996 Sorrentino BP, Spencer HT, Blaklev RL, Allav JA. Protection of hematopoietic cells from antifolate toxicity by a novel variant of human dihydrofolate reductase Experimental Hematology. 24: 1157.  0.68
1995 Harris LC, Marathi UK, Edwards CC, Houghton PJ, Srivastava DK, Vanin EF, Sorrentino BP, Brent TP. Retroviral Transfer of a Bacterial Alkyltransferase Gene into Murine Bone Marrow Protects Against Chloroethylnitrosourea Cytotoxicity Clinical Cancer Research. 1: 1359-1368. PMID 9815932  0.68
1995 Brenner MK, Cunningham JM, Sorrentino BP, Heslop HE. Gene transfer into human hemopoietic progenitor cells British Medical Bulletin. 51: 167-191. PMID 7767642  0.68
1995 Sorrentino BP, McDonagh KT, Woods D, Orlic D. Expression of retroviral vectors containing the human multidrug resistance 1 cDNA in hematopoietic cells of transplanted mice Blood. 86: 491-501. PMID 7605985  0.68
1995 Orlic D, Anderson S, Biesecker LG, Sorrentino BP, Bodine DM. Pluripotent hematopoietic stem cells contain high levels of mRNA for c- kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7 Proceedings of the National Academy of Sciences of the United States of America. 92: 4601-4605. PMID 7538677  0.68
1994 O'Shaughnessy JA, Cowan KH, Nienhuis AW, McDonagh KT, Sorrentino BP, Dunbar CE, Chiang Y, Wilson W, Goldspiel B, Kohler D. Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer. Human Gene Therapy. 5: 891-911. PMID 7526902 DOI: 10.1089/hum.1994.5.7-891  0.68
1993 Dunbar CE, Nienhuis AW, Stewart FM, Quesenberry P, O'Shaughnessy J, Cowan K, Cottler-Fox M, Leitman S, Goodman S, Sorrentino BP. Amendment to clinical research projects. Genetic marking with retroviral vectors to study the feasibility of stem cell gene transfer and the biology of hematopoietic reconstitution after autologous transplantation in multiple myeloma, chronic myelogenous leukemia, or metastatic breast cancer. Human Gene Therapy. 4: 205-22. PMID 8098622 DOI: 10.1089/hum.1993.4.2-205  0.68
1992 Sorrentino BP, Brandt SJ, Bodine D, Gottesman M, Pastan I, Cline A, Nienhuis AW. Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1 Science. 257: 99-103. PMID 1352414  0.68
1990 Sorrentino BP, Ney PA, Nienhuis AW. Localization and characterization of the DNase I-hypersensitive site II (HS II) enhancer: A critical regulatory element within the β-globin locus-activating region Annals of the New York Academy of Sciences. 612: 141-151. PMID 2291542 DOI: 10.1111/j.1749-6632.1990.tb24300.x  0.68
1990 Ney PA, Sorrentino BP, Lowrey CH, Nienhuis AW. Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein Nucleic Acids Research. 18: 6011-6017. PMID 2235483 DOI: 10.1093/nar/18.20.6011  0.68
1990 Ney PA, Sorrentino BP, McDonagh KT, Nienhuis AW. Tandem AP-1-binding sites within the human β-globin dominant control region function as an inducible enhancer in erythroid cells Genes and Development. 4: 993-1006. PMID 2116990  0.68
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