| Year |
Citation |
Score |
| 2023 |
Nayak AP, Javed E, Villalba DR, Wang Y, Morelli HP, Shah SD, Kim N, Ostrom RS, Panettieri RA, An SS, Tang DD, Penn RB. Pro-Relaxant EP Receptors Functionally Partition to Different Pro-Contractile Receptors in Airway Smooth Muscle. American Journal of Respiratory Cell and Molecular Biology. PMID 37523713 DOI: 10.1165/rcmb.2022-0445OC |
0.404 |
|
| 2023 |
Cattani-Cavalieri I, Li Y, Margolis J, Bogard A, Roosan MR, Ostrom RS. Quantitative phosphoproteomic analysis reveals unique cAMP signaling pools emanating from AC2 and AC6 in human airway smooth muscle cells. Frontiers in Physiology. 14: 1149063. PMID 36926196 DOI: 10.3389/fphys.2023.1149063 |
0.75 |
|
| 2021 |
Ostrom KF, LaVigne JE, Brust TF, Seifert R, Dessauer CW, Watts VJ, Ostrom RS. Physiological Roles of Mammalian Transmembrane Adenylyl Cyclase Isoforms. Physiological Reviews. PMID 34698552 DOI: 10.1152/physrev.00013.2021 |
0.624 |
|
| 2019 |
Nuñez FJ, Johnstone TB, Corpuz ML, Kazarian AG, Mohajer NN, Tliba O, Panettieri RA, Koziol-White C, Roosan MR, Ostrom RS. Glucocorticoids rapidly activate cAMP production via G to initiate non-genomic signaling that contributes to one-third of their canonical genomic effects. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31908022 DOI: 10.1096/fj.201902521R |
0.382 |
|
| 2019 |
Nunez FJ, Schulte NA, Fogel DM, Michalski J, Rennard SI, Penn RB, Toews ML, Ostrom RS. Agonist-specific desensitization of PGE-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 31884570 DOI: 10.1007/S00210-019-01800-5 |
0.386 |
|
| 2019 |
Koziol-White CJ, Johnstone TB, Corpuz ML, Cao G, Orfanos S, Parikh V, Deeney BT, Tliba O, Ostrom RS, Dainty I, Panettieri RA. Budesonide enhances agonist-induced bronchodilation in human small airways by increasing cAMP production in airway smooth muscle. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 31747297 DOI: 10.1152/ajplung.00393.2019 |
0.357 |
|
| 2019 |
Agarwal SR, Fiore C, Miyashiro K, Ostrom RS, Harvey RD. Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by Beta-2 Adrenoceptors in Human Airway Smooth Muscle Cells. The Journal of Pharmacology and Experimental Therapeutics. PMID 31068382 DOI: 10.1124/jpet.119.256594 |
0.5 |
|
| 2019 |
Sherpa RT, Mohieldin AM, Pala R, Wachten D, Ostrom RS, Nauli SM. Sensory primary cilium is a responsive cAMP microdomain in renal epithelia. Scientific Reports. 9: 6523. PMID 31024067 DOI: 10.1038/s41598-019-43002-2 |
0.334 |
|
| 2019 |
Dessauer CW, Ostrom R, Seifert R, Watts VJ. Adenylyl cyclases (ACs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f257/2019.4 |
0.52 |
|
| 2018 |
Agarwal SR, Miyashiro K, Latt H, Fiore C, Ostrom RS, Harvey RD. Differential Association of Adenylyl Cyclase Isoforms with Membrane Microdomains Regulates cAMP Compartmentation in Human Airway Smooth Muscle Cells Biophysical Journal. 114: 463a-464a. DOI: 10.1016/j.bpj.2017.11.2557 |
0.371 |
|
| 2017 |
Johnstone TB, Smith KH, Koziol-White CJ, Li F, Kazarian AG, Corpuz ML, Shumyatcher M, Ehlert FJ, Himes BE, Panettieri RA, Ostrom RS. PDE8 is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2AR-AC6. American Journal of Respiratory Cell and Molecular Biology. PMID 29262264 DOI: 10.1165/rcmb.2017-0294OC |
0.599 |
|
| 2017 |
Johnstone TB, Agarwal SR, Harvey RD, Ostrom RS. cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes. Molecular Pharmacology. PMID 29217670 DOI: 10.1124/mol.117.110825 |
0.403 |
|
| 2017 |
Du A, Huang S, Zhao X, Feng K, Zhang S, Huang J, Miao X, Baggi F, Ostrom RS, Zhang Y, Chen X, Xu C. Suppression of CHRN endocytosis by carbonic anhydrase CAR3 in the pathogenesis of myasthenia gravis. Autophagy. 0. PMID 28933591 DOI: 10.1080/15548627.2017.1375633 |
0.318 |
|
| 2017 |
Agarwal SR, Miyashiro K, Latt H, Ostrom RS, Harvey RD. Compartmentalized cAMP Responses to Prostaglandin EP2 Receptor Activation in Human Airway Smooth Muscle Cells. British Journal of Pharmacology. PMID 28603838 DOI: 10.1111/bph.13904 |
0.482 |
|
| 2017 |
Dessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, Seifert R. International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacological Reviews. 69: 93-139. PMID 28255005 DOI: 10.1124/Pr.116.013078 |
0.518 |
|
| 2014 |
Bogard AS, Birg AV, Ostrom RS. Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms. Naunyn-Schmiedeberg's Archives of Pharmacology. 387: 329-39. PMID 24363043 DOI: 10.1007/S00210-013-0950-4 |
0.73 |
|
| 2013 |
Cai W, Du A, Feng K, Zhao X, Qian L, Ostrom RS, Xu C. Adenylyl cyclase 6 activation negatively regulates TLR4 signaling through lipid raft-mediated endocytosis. Journal of Immunology (Baltimore, Md. : 1950). 191: 6093-100. PMID 24218452 DOI: 10.4049/jimmunol.1301912 |
0.364 |
|
| 2013 |
Conley JM, Brand CS, Bogard AS, Pratt EP, Xu R, Hockerman GH, Ostrom RS, Dessauer CW, Watts VJ. Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 347: 276-87. PMID 24008337 DOI: 10.1124/Jpet.113.207449 |
0.715 |
|
| 2012 |
Bogard AS, Adris P, Ostrom RS. Adenylyl cyclase 2 selectively couples to E prostanoid type 2 receptors, whereas adenylyl cyclase 3 is not receptor-regulated in airway smooth muscle. The Journal of Pharmacology and Experimental Therapeutics. 342: 586-95. PMID 22619251 DOI: 10.1124/Jpet.112.193425 |
0.758 |
|
| 2012 |
Ostrom RS, Bogard AS, Gros R, Feldman RD. Choreographing the adenylyl cyclase signalosome: sorting out the partners and the steps. Naunyn-Schmiedeberg's Archives of Pharmacology. 385: 5-12. PMID 22012074 DOI: 10.1007/S00210-011-0696-9 |
0.72 |
|
| 2011 |
Bogard AS, Xu C, Ostrom RS. Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. The Journal of Pharmacology and Experimental Therapeutics. 337: 209-17. PMID 21228062 DOI: 10.1124/Jpet.110.177923 |
0.75 |
|
| 2010 |
Liu X, Li F, Sun SQ, Thangavel M, Kaminsky J, Balazs L, Ostrom RS. Fibroblast-specific expression of AC6 enhances beta-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 298: L819-29. PMID 20348281 DOI: 10.1152/ajplung.00429.2009 |
0.302 |
|
| 2008 |
Liu X, Thangavel M, Sun SQ, Kaminsky J, Mahautmr P, Stitham J, Hwa J, Ostrom RS. Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 359-69. PMID 17934720 DOI: 10.1007/s00210-007-0196-0 |
0.422 |
|
| 2005 |
Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM. Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes. Annals of the New York Academy of Sciences. 1047: 166-72. PMID 16093494 DOI: 10.1196/Annals.1341.015 |
0.32 |
|
| 2004 |
Ostrom RS, Insel PA. The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. British Journal of Pharmacology. 143: 235-45. PMID 15289291 DOI: 10.1038/sj.bjp.0705930 |
0.431 |
|
| 2004 |
Liu X, Ostrom RS, Insel PA. cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts. American Journal of Physiology. Cell Physiology. 286: C1089-99. PMID 15075208 DOI: 10.1152/ajpcell.00461.2003 |
0.346 |
|
| 2004 |
Ostrom RS, Bundey RA, Insel PA. Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes. The Journal of Biological Chemistry. 279: 19846-53. PMID 15007069 DOI: 10.1074/jbc.M313440200 |
0.445 |
|
| 2003 |
Insel PA, Ostrom RS. Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling. Cellular and Molecular Neurobiology. 23: 305-14. PMID 12825829 DOI: 10.1023/A:1023684503883 |
0.536 |
|
| 2003 |
Ostrom RS, Naugle JE, Hase M, Gregorian C, Swaney JS, Insel PA, Brunton LL, Meszaros JG. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. The Journal of Biological Chemistry. 278: 24461-8. PMID 12711600 DOI: 10.1074/Jbc.M212659200 |
0.425 |
|
| 2002 |
Ostrom RS, Liu X, Head BP, Gregorian C, Seasholtz TM, Insel PA. Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: expression in caveolin-rich and noncaveolin domains. Molecular Pharmacology. 62: 983-92. PMID 12391260 DOI: 10.1124/Mol.62.5.983 |
0.621 |
|
| 2002 |
Ostrom RS, Rana BK, Insel PA. Stoichiometry of G protein-coupled receptor signaling: Implications in the genomic era Pharmaceutical News. 9: 295-303. DOI: 10.1080/10718940216630 |
0.401 |
|
| 2001 |
Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG. RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Science (New York, N.Y.). 294: 1939-42. PMID 11729322 DOI: 10.1126/Science.1064757 |
0.338 |
|
| 2001 |
Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. The Journal of Biological Chemistry. 276: 42063-9. PMID 11533056 DOI: 10.1074/Jbc.M105348200 |
0.356 |
|
| 2001 |
Ostrom RS, Gregorian C, Drenan RM, Gabot K, Rana BK, Insel PA. Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP. American Journal of Physiology. Cell Physiology. 281: C524-31. PMID 11443051 DOI: 10.1152/Ajpcell.2001.281.2.C524 |
0.434 |
|
| 1999 |
Xing M, Post S, Ostrom RS, Samardzija M, Insel PA. Inhibition of phospholipase A2-mediated arachidonic acid release by cyclic AMP defines a negative feedback loop for P2Y receptor activation in Madin-Darby canine kidney D1 cells. The Journal of Biological Chemistry. 274: 10035-8. PMID 10187781 DOI: 10.1074/Jbc.274.15.10035 |
0.383 |
|
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