| Year |
Citation |
Score |
| 2024 |
Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Melloni GEM, Kanoni S, Rayner NW, Bocher O, Arruda AL, Sonehara K, Namba S, ... ... Florez JC, et al. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature. PMID 38374256 DOI: 10.1038/s41586-024-07019-6 |
0.332 |
|
| 2024 |
Kwak SH, Srinivasan S, Chen L, Todd J, Mercader JM, Jensen ET, Divers J, Mottl AK, Pihoker C, Gandica RG, Laffel LM, Isganaitis E, Haymond MW, Levitsky LL, Pollin TI, ... Florez JC, et al. Genetic architecture and biology of youth-onset type 2 diabetes. Nature Metabolism. PMID 38278947 DOI: 10.1038/s42255-023-00970-0 |
0.375 |
|
| 2023 |
Srinivasan S, Wu P, Mercader JM, Udler MS, Porneala BC, Bartz TM, Floyd JS, Sitlani C, Guo X, Haessler J, Kooperberg C, Liu J, Ahmad S, van Duijn C, Liu CT, ... ... Florez JC, et al. A Type 1 Diabetes Polygenic Score Is Not Associated With Prevalent Type 2 Diabetes in Large Population Studies. Journal of the Endocrine Society. 7: bvad123. PMID 37841955 DOI: 10.1210/jendso/bvad123 |
0.353 |
|
| 2023 |
Schroeder P, Mandla R, Huerta-Chagoya A, Alkanak A, Nagy D, Szczerbinski L, Madsen JGS, Cole JB, Porneala B, Westerman K, Li JH, Pollin TI, Florez JC, Gloyn AL, Cebola I, et al. Rare variant association analysis in 51,256 type 2 diabetes cases and 370,487 controls informs the spectrum of pathogenicity of monogenic diabetes genes. Medrxiv : the Preprint Server For Health Sciences. PMID 37808701 DOI: 10.1101/2023.09.28.23296244 |
0.356 |
|
| 2023 |
Misra S, Ke C, Srinivasan S, Goyal A, Nyriyenda MJ, Florez JC, Khunti K, Magliano DJ, Luk A. Current insights and emerging trends in early-onset type 2 diabetes. The Lancet. Diabetes & Endocrinology. 11: 768-782. PMID 37708901 DOI: 10.1016/S2213-8587(23)00225-5 |
0.309 |
|
| 2023 |
Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG, Chen S, Todorov PV, Sharapov S, David A, Marullo L, Mägi R, Rujan RM, ... ... Florez JC, et al. GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification. Nature Genetics. 55: 1448-1461. PMID 37679419 DOI: 10.1038/s41588-023-01462-3 |
0.326 |
|
| 2023 |
Kwak SH, Hernandez-Cancela RB, DiCorpo DA, Condon DE, Merino J, Wu P, Brody JA, Yao J, Guo X, Ahmadizar F, Meyer M, Sincan M, Mercader JM, Lee S, Haessler J, ... ... Florez JC, et al. Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus. Medrxiv : the Preprint Server For Health Sciences. PMID 37546893 DOI: 10.1101/2023.07.25.23293180 |
0.331 |
|
| 2023 |
Deutsch AJ, Schroeder PH, Mandla R, Kang S, Erenler F, Mercader JM, Udler MS, Florez JC, Brenner LN. Type 2 Diabetes Polygenic Score Predicts the Risk of Glucocorticoid-Induced Hyperglycemia in Patients Without Diabetes. Diabetes Care. PMID 37353344 DOI: 10.2337/dc23-0353 |
0.357 |
|
| 2023 |
Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A, Udler MS, Leong A, Mercader JM, Florez JC. Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH. Diabetologia. PMID 37233759 DOI: 10.1007/s00125-023-05922-7 |
0.321 |
|
| 2023 |
Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbiński L, ... ... Florez JC, et al. The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes. Diabetologia. PMID 37148359 DOI: 10.1007/s00125-023-05912-9 |
0.32 |
|
| 2023 |
Misra S, Wagner R, Ozkan B, Schön M, Sevilla-Gonzalez M, Prystupa K, Wang CC, Kreienkamp RJ, Cromer SJ, Rooney MR, Duan D, Thuesen ACB, Wallace AS, Leong A, Deutsch AJ, ... ... Florez JC, et al. Systematic review of precision subclassification of type 2 diabetes. Medrxiv : the Preprint Server For Health Sciences. PMID 37131632 DOI: 10.1101/2023.04.19.23288577 |
0.302 |
|
| 2023 |
Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Rayner NW, Bocher O, Ana Luiza de SVA, Sonehara K, Namba S, Lee SSK, Preuss MH, ... ... Florez JC, et al. Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications. Medrxiv : the Preprint Server For Health Sciences. PMID 37034649 DOI: 10.1101/2023.03.31.23287839 |
0.345 |
|
| 2023 |
Costanzo MC, von Grotthuss M, Massung J, Jang D, Caulkins L, Koesterer R, Gilbert C, Welch RP, Kudtarkar P, Hoang Q, Boughton AP, Singh P, Sun Y, Duby M, Moriondo A, ... ... Florez JC, et al. The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits. Cell Metabolism. PMID 36963395 DOI: 10.1016/j.cmet.2023.03.001 |
0.312 |
|
| 2023 |
Cromer SJ, Lakhani CM, Mercader JM, Majarian TD, Schroeder P, Cole JB, Florez JC, Patel CJ, Manning AK, Burnett-Bowie SM, Merino J, Udler MS. Association and Interaction of Genetics and Area-Level Socioeconomic Factors on the Prevalence of Type 2 Diabetes and Obesity. Diabetes Care. PMID 36787958 DOI: 10.2337/dc22-1954 |
0.304 |
|
| 2022 |
Smyth LJ, Dahlström EH, Syreeni A, Kerr K, Kilner J, Doyle R, Brennan E, Nair V, Fermin D, Nelson RG, Looker HC, Wooster C, Andrews D, Anderson K, McKay GJ, ... ... Florez JC, et al. Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease. Nature Communications. 13: 7891. PMID 36550108 DOI: 10.1038/s41467-022-34963-6 |
0.309 |
|
| 2022 |
Kim H, Westerman KE, Smith K, Chiou J, Cole JB, Majarian T, von Grotthuss M, Kwak SH, Kim J, Mercader JM, Florez JC, Gaulton K, Manning AK, Udler MS. High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease. Diabetologia. PMID 36538063 DOI: 10.1007/s00125-022-05848-6 |
0.339 |
|
| 2022 |
Li JH, Perry JA, Jablonski KA, Srinivasan S, Chen L, Todd JN, Harden M, Mercader JM, Pan Q, Dawed AY, Yee SW, Pearson ER, Giacomini KM, Giri A, Hung AM, ... ... Florez JC, et al. Identification of Genetic Variation Influencing Metformin Response in a Multi-Ancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP). Diabetes. PMID 36525397 DOI: 10.2337/db22-0702 |
0.399 |
|
| 2022 |
Dornbos P, Koesterer R, Ruttenburg A, Nguyen T, Cole JB, Leong A, Meigs JB, Florez JC, Rotter JI, Udler MS, Flannick J. A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels. Nature Genetics. PMID 36280733 DOI: 10.1038/s41588-022-01200-1 |
0.307 |
|
| 2022 |
DiCorpo D, Gaynor SM, Russell EM, Westerman KE, Raffield LM, Majarian TD, Wu P, Sarnowski C, Highland HM, Jackson A, Hasbani NR, de Vries PS, Brody JA, Hidalgo B, Guo X, ... ... Florez JC, et al. Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program. Communications Biology. 5: 756. PMID 35902682 DOI: 10.1038/s42003-022-03702-4 |
0.314 |
|
| 2022 |
Florez JC, Pearson ER. A roadmap to achieve pharmacological precision medicine in diabetes. Diabetologia. PMID 35748917 DOI: 10.1007/s00125-022-05732-3 |
0.339 |
|
| 2022 |
Dorsey-Trevino EG, Kaur V, Mercader JM, Florez JC, Leong A. Association of GLP1R polymorphisms with the incretin response. The Journal of Clinical Endocrinology and Metabolism. PMID 35723666 DOI: 10.1210/clinem/dgac374 |
0.301 |
|
| 2022 |
Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Rüeger S, Speidel L, Kim YJ, Horikoshi M, Mercader JM, Taliun D, Moon S, Kwak SH, ... ... Florez JC, et al. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nature Genetics. PMID 35551307 DOI: 10.1038/s41588-022-01058-3 |
0.385 |
|
| 2022 |
Merino J, Guasch-Ferré M, Li J, Chung W, Hu Y, Ma B, Li Y, Kang JH, Kraft P, Liang L, Sun Q, Franks PW, Manson JE, Willet WC, Florez JC, et al. Polygenic scores, diet quality, and type 2 diabetes risk: An observational study among 35,759 adults from 3 US cohorts. Plos Medicine. 19: e1003972. PMID 35472203 DOI: 10.1371/journal.pmed.1003972 |
0.327 |
|
| 2022 |
Maxwell TJ, Franks PW, Kahn SE, Knowler WC, Mather KJ, Florez JC, Jablonski KA. Quantitative trait loci, G×E and G×G for glycemic traits: response to metformin and placebo in the Diabetes Prevention Program (DPP). Journal of Human Genetics. PMID 35260800 DOI: 10.1038/s10038-022-01027-y |
0.386 |
|
| 2022 |
DiCorpo D, LeClair J, Cole JB, Sarnowski C, Ahmadizar F, Bielak LF, Blokstra A, Bottinger EP, Chaker L, Chen YI, Chen Y, de Vries PS, Faquih T, Ghanbari M, Gudmundsdottir V, ... ... Florez JC, et al. Type 2 Diabetes Partitioned Polygenic Scores Associate With Disease Outcomes in 454,193 individuals Across 13 Cohorts. Diabetes Care. PMID 35085396 DOI: 10.2337/dc21-1395 |
0.301 |
|
| 2022 |
Garaulet M, Lopez-Minguez J, Dashti HS, Vetter C, Hernández-Martínez AM, Pérez-Ayala M, Baraza JC, Wang W, Florez JC, Scheer FAJL, Saxena R. Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. Diabetes Care. PMID 35015083 DOI: 10.2337/dc21-1314 |
0.325 |
|
| 2022 |
Srinivasan S, Chen L, Todd J, Divers J, Gidding S, Chernausek S, Gubitosi-Klug RA, Kelsey MM, Shah R, Black MH, Wagenknecht LE, Manning A, Flannick J, Imperatore G, Mercader JM, ... ... Florez JC, et al. Erratum. The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium. Diabetes 2021;70:996-1005. Diabetes. PMID 34957479 DOI: 10.2337/db22-er01a |
0.361 |
|
| 2021 |
O'Connor MJ, Schroeder P, Huerta-Chagoya A, Cortés-Sánchez P, Bonàs-Guarch S, Guindo-Martínez M, Cole JB, Kaur V, Torrents D, Veerapen K, Grarup N, Kurki M, Rundsten CF, Pedersen O, Brandslund I, ... ... Florez JC, et al. Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes. Diabetes. PMID 34862199 DOI: 10.2337/db21-0545 |
0.397 |
|
| 2021 |
Mansour Aly D, Dwivedi OP, Prasad RB, Käräjämäki A, Hjort R, Thangam M, Åkerlund M, Mahajan A, Udler MS, Florez JC, McCarthy MI, Brosnan J, Melander O, Carlsson S, et al. Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes. Nature Genetics. 53: 1534-1542. PMID 34737425 DOI: 10.1038/s41588-021-00948-2 |
0.416 |
|
| 2021 |
Srinivasan S, Chen L, Todd J, Divers J, Gidding S, Chernausek S, Gubitosi-Klug RA, Kelsey MM, Shah R, Black MH, Wagenknecht LE, Manning A, Flannick J, Imperatore G, Mercader JM, ... ... Florez JC, et al. Erratum. The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium. Diabetes 2021;70:996-1005. Diabetes. PMID 34716200 DOI: 10.2337/db22-er01a |
0.361 |
|
| 2021 |
Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A, Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC, Mercader JM, ... ... Florez JC, et al. Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas. Diabetes Care. PMID 34607834 DOI: 10.2337/dc21-1152 |
0.306 |
|
| 2021 |
Santoro N, Chen L, Todd J, Divers J, Shah AS, Gidding SS, Burke B, Haymond M, Lange L, Marcovina S, Flannick J, Caprio S, Florez JC, Srinivasan S. Genome-wide Association Study of Lipid Traits in Youth With Type 2 Diabetes. Journal of the Endocrine Society. 5: bvab139. PMID 34568709 DOI: 10.1210/jendso/bvab139 |
0.324 |
|
| 2021 |
Todd JN, Kleinberger JW, Zhang H, Srinivasan S, Tollefsen SE, Levitsky LL, Levitt Katz LE, Tryggestad JB, Bacha F, Imperatore G, Lawrence JM, Pihoker C, Divers J, Flannick J, Dabelea D, ... Florez JC, et al. Monogenic Diabetes in Youth With Presumed Type 2 Diabetes: Results From the Progress in Diabetes Genetics in Youth (ProDiGY) Collaboration. Diabetes Care. PMID 34362814 DOI: 10.2337/dc21-0491 |
0.33 |
|
| 2021 |
Goodrich JK, Singer-Berk M, Son R, Sveden A, Wood J, England E, Cole JB, Weisburd B, Watts N, Caulkins L, Dornbos P, Koesterer R, Zappala Z, Zhang H, Maloney KA, ... ... Florez JC, et al. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nature Communications. 12: 3505. PMID 34108472 DOI: 10.1038/s41467-021-23556-4 |
0.325 |
|
| 2021 |
Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y, Zhang X, Horikoshi M, Boutin TS, Mägi R, Waage J, Li-Gao R, Chan KHK, ... ... Florez JC, et al. The trans-ancestral genomic architecture of glycemic traits. Nature Genetics. PMID 34059833 DOI: 10.1038/s41588-021-00852-9 |
0.358 |
|
| 2021 |
Srinivasan S, Chen L, Todd J, Divers J, Gidding S, Chernausek S, Gubitosi-Klug RA, Kelsey MM, Shah R, Black MH, Wagenknecht LE, Manning A, Flannick J, Imperatore G, Mercader JM, ... ... Florez JC, et al. The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium. Diabetes. PMID 33479058 DOI: 10.2337/db20-0443 |
0.386 |
|
| 2021 |
Raghavan S, Jablonski K, Delahanty LM, Maruthur NM, Leong A, Franks PW, Knowler WC, Florez JC, Dabelea D. Interaction of diabetes genetic risk and successful lifestyle modification in the Diabetes Prevention Program. Diabetes, Obesity & Metabolism. PMID 33394545 DOI: 10.1111/dom.14309 |
0.333 |
|
| 2020 |
Brenner LN, Mercader JM, Robertson CC, Cole J, Chen L, Jacobs SBR, Rich SS, Florez JC. Analysis of Glucocorticoid-Related Genes Reveal as a New Candidate Gene for Type 2 Diabetes. Journal of the Endocrine Society. 4: bvaa121. PMID 33150273 DOI: 10.1210/Jendso/Bvaa121 |
0.45 |
|
| 2020 |
Li JH, Szczerbinski L, Dawed AY, Kaur V, Todd JN, Pearson ER, Florez JC. A Polygenic Score for Type 2 Diabetes Risk is Associated with Both the Acute and Sustained Response to Sulfonylureas. Diabetes. PMID 33106254 DOI: 10.2337/db20-0530 |
0.376 |
|
| 2020 |
Ezzat S, Zheng L, Florez JC, Stefan N, Mayr T, Hliang MM, Jablonski K, Harden M, Stanĉáková A, Laakso M, Haring HU, Ullrich A, Asa SL. Retraction Notice to: The Cancer-Associated FGFR4-G388R Polymorphism Enhances Pancreatic Insulin Secretion and Modifies the Risk of Diabetes. Cell Metabolism. 32: 691. PMID 33027678 DOI: 10.1016/j.cmet.2020.09.009 |
0.311 |
|
| 2020 |
Chung WK, Erion K, Florez JC, Hattersley AT, Hivert MF, Lee CG, McCarthy MI, Nolan JJ, Norris JM, Pearson ER, Philipson L, McElvaine AT, Cefalu WT, Rich SS, Franks PW. Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 43: 1617-1635. PMID 32561617 DOI: 10.2337/Dci20-0022 |
0.44 |
|
| 2020 |
Chung WK, Erion K, Florez JC, Hattersley AT, Hivert MF, Lee CG, McCarthy MI, Nolan JJ, Norris JM, Pearson ER, Philipson L, McElvaine AT, Cefalu WT, Rich SS, Franks PW. Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. PMID 32556613 DOI: 10.1007/S00125-020-05181-W |
0.44 |
|
| 2020 |
Cole JB, Florez JC. Genetics of diabetes mellitus and diabetes complications. Nature Reviews. Nephrology. PMID 32398868 DOI: 10.1038/S41581-020-0278-5 |
0.473 |
|
| 2020 |
Wu P, Rybin D, Bielak LF, Feitosa MF, Franceschini N, Li Y, Lu Y, Marten J, Musani SK, Noordam R, Raghavan S, Rose LM, Schwander K, Smith AV, Tajuddin SM, ... ... Florez JC, et al. Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose. Plos One. 15: e0230815. PMID 32379818 DOI: 10.1371/Journal.Pone.0230815 |
0.361 |
|
| 2020 |
Cole JB, Florez JC, Hirschhorn JN. Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations. Nature Communications. 11: 1467. PMID 32193382 DOI: 10.1038/S41467-020-15193-0 |
0.348 |
|
| 2020 |
Klonoff DC, Florez JC, German M, Fleming A. The Need for Precision Medicine to be Applied to Diabetes. Journal of Diabetes Science and Technology. 1932296819894295. PMID 31903769 DOI: 10.1177/1932296819894295 |
0.374 |
|
| 2020 |
Garaulet M, Qian J, Florez JC, Arendt J, Saxena R, Scheer FAJL. Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy. Trends in Endocrinology and Metabolism: Tem. PMID 31901302 DOI: 10.1016/J.Tem.2019.11.011 |
0.381 |
|
| 2020 |
Mercader JM, Florez JC, Leong A, Kaur V, Udler M, Meigs JB, Porneala B. 240-OR: Combining Type 2 Diabetes Polygenic Scores Improves Prediction in 36,000 European and Non-European Participants in the Partners Healthcare Biobank Diabetes. 69. DOI: 10.2337/Db20-240-Or |
0.402 |
|
| 2020 |
Powe CE, Udler M, Hsu S, Kuang A, Allard C, Manning A, Bouchard L, Perron P, Florez JC, Lowe W, Scholtens D, Hivert M. 193-OR: Physiology-Informed Type 2 Diabetes Genetic Clusters and Gestational Diabetes Diabetes. 69. DOI: 10.2337/Db20-193-Or |
0.424 |
|
| 2020 |
Kwak SH, Mercader JM, Leong A, Porneala B, Wu P, Cole JB, Merino J, Park KS, Cho NH, Dupuis J, Florez JC, Meigs JB. 1655-P: Genetic Risk Factors for Incident Cardiovascular Disease in Type 2 Diabetes Patients Diabetes. 69. DOI: 10.2337/Db20-1655-P |
0.423 |
|
| 2020 |
Kim H, Grotthuss MV, Mercader JM, Chiou J, Gaulton KJ, Manning A, Florez JC, Udler M. 1644-P: High Throughput Approach Enables Expanded Clustering of Type 2 Diabetes Genetic Loci Informed by Phenotypic Associations Diabetes. 69. DOI: 10.2337/Db20-1644-P |
0.373 |
|
| 2020 |
O’Connor MJ, Cortes-Sanchez P, Bonàs-Guarch S, Cole JB, Torrents D, Leong A, Florez JC, Mercader JM. 1643-P: A Recessive Genome-Wide Meta-analysis of Type 2 Diabetes in 300,000 Individuals of European Ancestry Identifies Multiple Novel Variants of Large Effect Size Diabetes. 69. DOI: 10.2337/Db20-1643-P |
0.436 |
|
| 2019 |
Chen L, Li JH, Kaur V, Muhammad A, Fernandez M, Hudson MS, Goldfine AB, Florez JC. The presence of two reduced function variants in CYP2C9 influences the acute response to glipizide. Diabetic Medicine : a Journal of the British Diabetic Association. PMID 31709648 DOI: 10.1111/Dme.14176 |
0.37 |
|
| 2019 |
Merino J, Jablonski KA, Mercader JM, Kahn SE, Chen L, Harden M, Delahanty LM, Araneta MRG, Walford GA, Jacobs SBR, Ibebuogu UN, Franks PW, Knowler WC, Florez JC. Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors. Diabetes. PMID 31636172 DOI: 10.2337/Db19-0097 |
0.412 |
|
| 2019 |
Hoch E, Florez JC, Lander ES, Jacobs SBR. Gain-of-Function Claims for Type-2-Diabetes-Associated Coding Variants in SLC16A11 Are Not Supported by the Experimental Data. Cell Reports. 29: 778-780. PMID 31618643 DOI: 10.1016/J.Celrep.2019.09.021 |
0.372 |
|
| 2019 |
Chen ZZ, Liu J, Morningstar J, Heckman-Stoddard BM, Lee CG, Dagogo-Jack S, Ferguson JF, Hamman RF, Knowler WC, Mather KJ, Perreault L, Florez JC, Wang TJ, Clish C, Temprosa M, et al. Metabolite Profiles of Incident Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program. Diabetes. PMID 31582408 DOI: 10.2337/Db19-0236 |
0.444 |
|
| 2019 |
Salem RM, Todd JN, Sandholm N, Cole JB, Chen WM, Andrews D, Pezzolesi MG, McKeigue PM, Hiraki LT, Qiu C, Nair V, Di Liao C, Cao JJ, Valo E, Onengut-Gumuscu S, ... ... Florez JC, et al. Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen. Journal of the American Society of Nephrology : Jasn. PMID 31537649 DOI: 10.1681/Asn.2019030218 |
0.443 |
|
| 2019 |
Srinivasan S, Jablonski KA, Knowler WC, Dagogo-Jack S, E Kahn S, Boyko EJ, Bray GA, Horton ES, Hivert MF, Goldberg R, Chen L, Mercader J, Harden M, Florez JC. A Polygenic Lipodystrophy Genetic Risk Score Characterizes Risk Independent of BMI in the Diabetes Prevention Program. Journal of the Endocrine Society. 3: 1663-1677. PMID 31428720 DOI: 10.1210/Js.2019-00069 |
0.437 |
|
| 2019 |
Udler MS, McCarthy MI, Florez JC, Mahajan A. Genetic risk scores for diabetes diagnosis and precision medicine. Endocrine Reviews. PMID 31322649 DOI: 10.1210/Er.2019-00088 |
0.444 |
|
| 2019 |
Liu CT, Merino J, Rybin D, DiCorpo D, Benke KS, Bragg-Gresham JL, Canouil M, Corre T, Grallert H, Isaacs A, Kutalik Z, Lahti J, Marullo L, Marzi C, Rasmussen-Torvik LJ, ... ... Florez JC, et al. Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals. Scientific Reports. 9: 9439. PMID 31263163 DOI: 10.1038/S41598-019-45823-7 |
0.419 |
|
| 2019 |
Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, ... ... Florez JC, et al. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. PMID 31118516 DOI: 10.1038/s41586-019-1231-2 |
0.342 |
|
| 2019 |
Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL, Fine RS, Guo X, Schurmann C, Lempradl A, Marouli E, Mahajan A, Winkler TW, ... ... Florez JC, et al. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics. PMID 30778226 DOI: 10.1038/S41588-018-0334-2 |
0.311 |
|
| 2019 |
Kim W, Deik A, Gonzalez C, Gonzalez ME, Fu F, Ferrari M, Churchhouse CL, Florez JC, Jacobs SBR, Clish CB, Rhee EP. Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD Recycling. Cell Metabolism. PMID 30686744 DOI: 10.1016/J.Cmet.2018.12.023 |
0.314 |
|
| 2019 |
Powe CE, Udler M, Allard C, Kim J, Perron P, Bouchard L, Florez JC, Hivert M. 354-OR: Physiologic Pathways in Pregnancy Glycemic Regulation Implicated through Genetic Clustering Analysis Diabetes. 68. DOI: 10.2337/Db19-354-Or |
0.41 |
|
| 2019 |
COLE JB, LEONG A, HIRSCHHORN J, FLOREZ JC. 308-OR: Genome-Wide Association Study of Food Frequency Questionnaire Single Nutrients and Dietary Patterns Uncover Hundreds of Genetic Associations Diabetes. 68: 308-OR. DOI: 10.2337/Db19-308-Or |
0.436 |
|
| 2019 |
Raghavan S, Jablonski KA, Delahanty LM, Maruthur N, Leong A, Franks PW, Knowler WC, Florez JC, Dabelea D. 307-OR: Interaction of Diabetes Genetic Risk and Successful Lifestyle Modification in the Diabetes Prevention Program Diabetes. 68. DOI: 10.2337/Db19-307-Or |
0.379 |
|
| 2019 |
CHEN L, SRINIVASAN S, SANTORO N, TODD J, DIVERS J, SHAH AS, GIDDING S, BURKE BK, HAYMOND MW, LANGE L, MARCOVINA SM, CHAIT A, FLANNICK J, CAPRIO S, FLOREZ JC. 177-OR: Genome-Wide Association Study of Lipid Traits in Youth with Type 2 Diabetes: The ProDiGY (Progress in Diabetes Genetics in Youth) Consortium Diabetes. 68: 177-OR. DOI: 10.2337/Db19-177-Or |
0.422 |
|
| 2019 |
Li JH, Szczerbinski L, Kaur V, Todd J, Florez JC. 1723-P: Genetic Risk Scores Predict Glycemic Traits and Response to Glipizide Treatment in the Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH) Diabetes. 68. DOI: 10.2337/Db19-1723-P |
0.327 |
|
| 2019 |
Merino J, Cole JB, Lim E, Yates K, Liu C, Florez JC. 1572-P: Association of Genetic Variants Related to Hyperinsulinemia with Dietary Intake Diabetes. 68. DOI: 10.2337/Db19-1572-P |
0.358 |
|
| 2019 |
Chen Z, Liu J, Morningstar J, Heckman-Stoddard BM, Lee C, Dagogo-Jack S, Ferguson JF, Hamman RF, Knowler WC, Mather KJ, Perreault L, Florez JC, Wang T, Clish CB, Temprosa M, et al. 1507-P: Baseline Metabolite Profiles of Incident Type 2 Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program (DPP) Diabetes. 68. DOI: 10.2337/Db19-1507-P |
0.356 |
|
| 2019 |
Powe C, Allard C, Perron P, Bouchard L, Florez J, Hivert M. SAT-123 Burden of Type 2 Diabetes Genetic Risk Alleles Differs Among Physiologic Subtypes of Gestational Diabetes Mellitus Journal of the Endocrine Society. 3. DOI: 10.1210/Js.2019-Sat-123 |
0.468 |
|
| 2018 |
Almeda-Valdes P, Gomez-Velasco D, Arellano-Campos O, Bello-Chavolla OY, Sevilla-González MDR, Viveros-Ruiz T, Martagón AJ, Bautista CJ, Muñoz Hernández L, Cruz-Bautista I, Moreno-Macias H, Huerta-Chagoya A, Rodríguez-Álvarez KG, Walford GA, Jacobs S, ... ... Florez JC, et al. The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-sized adipocytes. European Journal of Endocrinology. PMID 30475225 DOI: 10.1530/Eje-18-0677 |
0.438 |
|
| 2018 |
Hivert MF, Christophi C, Jablonski K, Edelstein S, Kahn S, Golden SH, Dagogo-Jack S, Mather KJ, Luchsinger JA, Caballero AE, Barrett-Connor E, Knowler WC, Florez JC, Herman WH. Genetic ancestry markers and difference in A1c between African-American and White in the Diabetes Prevention Program. The Journal of Clinical Endocrinology and Metabolism. PMID 30358859 DOI: 10.1210/Jc.2018-01416 |
0.406 |
|
| 2018 |
Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, Payne AJ, Steinthorsdottir V, Scott RA, Grarup N, Cook JP, Schmidt EM, Wuttke M, Sarnowski C, Mägi R, ... ... Florez JC, et al. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics. PMID 30297969 DOI: 10.1038/S41588-018-0241-6 |
0.422 |
|
| 2018 |
Powe CE, Nodzenski M, Talbot O, Allard C, Briggs C, Leya MV, Perron P, Bouchard L, Florez JC, Scholtens DM, Lowe WL, Hivert MF. Genetic Determinants of Glycemic Traits and the Risk of Gestational Diabetes Mellitus. Diabetes. PMID 30257980 DOI: 10.2337/Db18-0203 |
0.405 |
|
| 2018 |
Udler MS, Kim J, von Grotthuss M, Bonàs-Guarch S, Cole JB, Chiou J, Boehnke M, Laakso M, Atzmon G, Glaser B, Mercader JM, Gaulton K, Flannick J, Getz G, ... Florez JC, et al. Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis. Plos Medicine. 15: e1002654. PMID 30240442 DOI: 10.1371/Journal.Pmed.1002654 |
0.41 |
|
| 2018 |
Fitipaldi H, McCarthy MI, Florez JC, Franks PW. A Global Overview of Precision Medicine in Type 2 Diabetes. Diabetes. 67: 1911-1922. PMID 30237159 DOI: 10.2337/Dbi17-0045 |
0.314 |
|
| 2018 |
Merino J, Dashti HS, Li SX, Sarnowski C, Justice AE, Graff M, Papoutsakis C, Smith CE, Dedoussis GV, Lemaitre RN, Wojczynski MK, Männistö S, Ngwa JS, Kho M, Ahluwalia TS, ... ... Florez JC, et al. Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Molecular Psychiatry. PMID 29988085 DOI: 10.1038/S41380-018-0079-4 |
0.37 |
|
| 2018 |
Gusarova V, O'Dushlaine C, Teslovich TM, Benotti PN, Mirshahi T, Gottesman O, Van Hout CV, Murray MF, Mahajan A, Nielsen JB, Fritsche L, Wulff AB, Gudbjartsson DF, Sjögren M, Emdin CA, ... ... Florez JC, et al. Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nature Communications. 9: 2252. PMID 29899519 DOI: 10.1038/S41467-018-04611-Z |
0.437 |
|
| 2018 |
Bonàs-Guarch S, Guindo-Martínez M, Miguel-Escalada I, Grarup N, Sebastian D, Rodriguez-Fos E, Sánchez F, Planas-Fèlix M, Cortes-Sánchez P, González S, Timshel P, Pers TH, Morgan CC, Moran I, Atla G, ... ... Florez JC, et al. Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. Nature Communications. 9: 2162. PMID 29849136 DOI: 10.1038/S41467-018-04170-3 |
0.346 |
|
| 2018 |
Martagón AJ, Bello-Chavolla OY, Arellano-Campos O, Almeda-Valdés P, Walford GA, Cruz-Bautista I, Gómez-Velasco DV, Mehta R, Muñoz-Hernández L, Sevilla-González M, Viveros-Ruiz TL, Ordoñez-Sánchez ML, Rodríguez-Guillen R, Florez JC, Tusié-Luna MT, et al. Mexican Carriers of the p.E508K Variant Do Not Experience an Enhanced Response to Sulfonylureas. Diabetes Care. PMID 29844095 DOI: 10.2337/Dc18-0384 |
0.386 |
|
| 2018 |
van Zuydam NR, Ahlqvist E, Sandholm N, Deshmukh H, Rayner NW, Abdalla M, Ladenvall C, Ziemek D, Fauman E, Robertson NR, McKeigue PM, Valo E, Forsblom C, Harjutsalo V, ... ... Florez JC, et al. A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. Diabetes. PMID 29703844 DOI: 10.2337/Db17-0914 |
0.45 |
|
| 2018 |
Vassy JL, Hivert MF, Porneala B, Dauriz M, Florez JC, Dupuis J, Siscovick DS, Fornage M, Rasmussen-Torvik LJ, Bouchard C, Meigs JB. Erratum. Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection. Diabetes 2014;63:2172-2182. Diabetes. PMID 29669744 DOI: 10.2337/Db18-Er06A |
0.435 |
|
| 2018 |
Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H, Taliun D, Rayner NW, Guo X, Lu Y, Li M, Jensen RA, Hu Y, ... ... Florez JC, et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics. 50: 559-571. PMID 29632382 DOI: 10.1038/S41588-018-0084-1 |
0.378 |
|
| 2018 |
Merino J, Leong A, Liu CT, Porneala B, Walford GA, von Grotthuss M, Wang TJ, Flannick J, Dupuis J, Levy D, Gerszten RE, Florez JC, Meigs JB. Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose. Diabetologia. PMID 29626220 DOI: 10.1007/S00125-018-4599-X |
0.423 |
|
| 2018 |
Kayatekin C, Amasino A, Gaglia G, Flannick J, Bonner JM, Fanning S, Narayan P, Barrasa MI, Pincus D, Landgraf D, Nelson J, Hesse WR, Costanzo M, Myers CL, ... ... Florez JC, et al. Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity. Cell. PMID 29526462 DOI: 10.1016/J.Cell.2018.02.026 |
0.386 |
|
| 2018 |
Merino J, Florez JC. Precision medicine in diabetes: an opportunity for clinical translation. Annals of the New York Academy of Sciences. 1411: 140-152. PMID 29377200 DOI: 10.1111/Nyas.13588 |
0.433 |
|
| 2018 |
Bonàs-Guarch S, Guindo-Martínez M, Miguel-Escalada I, Grarup N, Sebastian D, Rodriguez-Fos E, Sánchez F, Planas-Fèlix M, Cortes-Sánchez P, González S, Timshel P, Pers TH, Morgan CC, Moran I, Atla G, ... ... Florez JC, et al. Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. Nature Communications. 9: 321. PMID 29358691 DOI: 10.1038/S41467-017-02380-9 |
0.469 |
|
| 2018 |
Srinivasan S, Kaur V, Chamarthi B, Littleton KR, Chen L, Manning AK, Merino J, Thomas MK, Hudson M, Goldfine A, Florez JC. TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH). Diabetes Care. PMID 29326107 DOI: 10.2337/Dc17-1386 |
0.44 |
|
| 2018 |
Vassy JL, He W, Florez JC, Meigs JB, Grant RW. Six-Year Diabetes Incidence After Genetic Risk Testing and Counseling: A Randomized Clinical Trial. Diabetes Care. PMID 29305403 DOI: 10.2337/Dc17-1793 |
0.463 |
|
| 2018 |
Astley CM, Todd JN, Salem RM, Vedantam S, Ebbeling CB, Huang PL, Ludwig DS, Hirschhorn JN, Florez JC. Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity. Clinical Chemistry. 64: 192-200. PMID 29295838 DOI: 10.1373/Clinchem.2017.280727 |
0.302 |
|
| 2018 |
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, ... ... Florez JC, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics. 50: 26-41. PMID 29273807 DOI: 10.1038/S41588-017-0011-X |
0.339 |
|
| 2018 |
TODD J, KLEINBERGER JW, SRINIVASAN S, TOLLEFSEN SE, LEVITSKY LL, KATZ LE, TRYGGESTAD JB, BACHA F, IMPERATORE G, LAWRENCE JM, PIHOKER C, DIVERS J, FLANNICK J, DABELEA D, FLOREZ JC, et al. Monogenic Diabetes in the Progress for Diabetes Genetics in Youth (ProDiGY) Collaboration Diabetes. 67: 268-OR. DOI: 10.2337/Db18-268-Or |
0.437 |
|
| 2018 |
Merino J, Dashti HS, Guasch M, Ellervik C, Smith C, Kilpelainen TO, Chasman D, Florez JC. Dietary Fat Quality and Genetic Risk of Type 2 Diabetes Diabetes. 67. DOI: 10.2337/Db18-21-Or |
0.375 |
|
| 2018 |
DASHTI HS, MERINO J, LANE JM, FLOREZ JC, RUTTER MK, SAXENA R. Multitrait Genome-Wide Association Analysis of Macronutrient Intake Identifies 12 Novel Loci for Dietary Intake and Unravels Genetic Overlap with Lifestyle Traits and Cardiometabolic Diseases Diabetes. 67: 176-OR. DOI: 10.2337/Db18-176-Or |
0.335 |
|
| 2018 |
Maxwell TJ, Jablonski KA, Franks PW, Kahn SE, Knowler WC, Mather KJ, Florez JC. Quantitative Trait Loci G×E and G×G for Glycemic Traits—Response to Metformin and Placebo in the Diabetes Prevention Program (DPP) Diabetes. 67. DOI: 10.2337/Db18-1711-P |
0.418 |
|
| 2018 |
Hivert M, Christophi CA, Jablonski KA, Edelstein S, Kahn SE, Golden S, Dagogo-Jack S, Mather KJ, Luchsinger JA, Caballero AE, Barrett-Connor E, Knowler WC, Florez JC, Herman WH. Genetic Markers Explain Differences in HbA1c Levels between African-American (AA) and Non-Hispanic White (NHW) Participants of the Diabetes Prevention Program (DPP) Diabetes. 67. DOI: 10.2337/Db18-1704-P |
0.403 |
|
| 2017 |
Mercader JM, Florez JC. The Genetic Basis of Type 2 Diabetes in Hispanics and Latin Americans: Challenges and Opportunities. Frontiers in Public Health. 5: 329. PMID 29376044 DOI: 10.3389/Fpubh.2017.00329 |
0.411 |
|
| 2017 |
Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Cingolani P, Gaulton KJ, Dyer T, Blackwell TW, Chen H, Chines PS, Choi S, ... ... Florez JC, et al. Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proceedings of the National Academy of Sciences of the United States of America. PMID 29279374 DOI: 10.1073/Pnas.1705859115 |
0.452 |
|
| 2017 |
Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, ... ... Florez JC, et al. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data. 4: 170179. PMID 29257133 DOI: 10.1038/Sdata.2017.179 |
0.393 |
|
| 2017 |
Florez JC. Genetics and biobanks converge to resolve a vexing knowledge gap in diabetes. The Lancet. Diabetes & Endocrinology. PMID 29199113 DOI: 10.1016/S2213-8587(17)30399-6 |
0.427 |
|
| 2017 |
Strawbridge RJ, Silveira A, Hoed MD, Gustafsson S, Luan J, Rybin D, Dupuis J, Li-Gao R, Kavousi M, Dehghan A, Haljas K, Lahti J, Gådin JR, Bäcklund A, de Faire U, ... ... Florez JC, et al. Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation. Atherosclerosis. 266: 196-204. PMID 29040868 DOI: 10.1016/J.Atherosclerosis.2017.09.031 |
0.362 |
|
| 2017 |
Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, Chu AY, Zhang W, Wang X, Chen P, Maruthur NM, ... ... Florez JC, et al. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. Plos Medicine. 14: e1002383. PMID 28898252 DOI: 10.1371/Journal.Pmed.1002383 |
0.505 |
|
| 2017 |
Mercader JM, Liao RG, Davis A, Dymek Z, Estrada K, Tukiainen T, Huerta-Chagoya A, Moreno-Macías H, Jablonski KA, Hanson RL, Walford GA, Moran I, Chen L, Agarwala V, Ordoñez-Sánchez ML, ... ... Florez JC, et al. A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes. Diabetes. PMID 28838971 DOI: 10.2337/Db17-0187 |
0.44 |
|
| 2017 |
Florez JC. The pharmacogenetics of metformin. Diabetologia. PMID 28770331 DOI: 10.1007/S00125-017-4335-Y |
0.378 |
|
| 2017 |
Rusu V, Hoch E, Mercader JM, Tenen DE, Gymrek M, Hartigan CR, DeRan M, von Grotthuss M, Fontanillas P, Spooner A, Guzman G, Deik AA, Pierce KA, Dennis C, Clish CB, ... ... Florez JC, et al. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Cell. 170: 199-212.e20. PMID 28666119 DOI: 10.1016/J.Cell.2017.06.011 |
0.466 |
|
| 2017 |
Florez JC. Mining the Genome for Therapeutic Targets. Diabetes. PMID 28603140 DOI: 10.2337/Dbi16-0069 |
0.373 |
|
| 2017 |
Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH, Johnson AD, Eicher JD, Jackson AU, Ferreira T, Lee Y, Ma C, Steinthorsdottir V, ... ... Florez JC, et al. An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes. PMID 28566273 DOI: 10.2337/Db16-1253 |
0.46 |
|
| 2017 |
Billings LK, Jablonski KA, Warner AS, Cheng YC, McAteer JB, Tipton L, Shuldiner AR, Ehrmann DA, Manning AK, Dabelea D, Franks PW, Kahn SE, Pollin TI, Knowler WC, Altshuler D, ... Florez JC, et al. Variation in Maturity-Onset Diabetes of the Young genes influence response to interventions for diabetes prevention. The Journal of Clinical Endocrinology and Metabolism. PMID 28453780 DOI: 10.1210/Jc.2016-3429 |
0.449 |
|
| 2017 |
Emdin CA, Klarin D, Natarajan P, Florez JC, Kathiresan S, Khera AV. Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease. Diabetes. PMID 28411266 DOI: 10.2337/Db17-0149 |
0.43 |
|
| 2017 |
Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, ... ... Florez JC, et al. A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes. PMID 28341696 DOI: 10.2337/Db16-1329 |
0.459 |
|
| 2017 |
Merino J, Leong A, Posner DC, Porneala B, Masana L, Dupuis J, Florez JC. Genetically Driven Hyperglycemia Increases Risk of Coronary Artery Disease Separately From Type 2 Diabetes. Diabetes Care. PMID 28298470 DOI: 10.2337/Dc16-2625 |
0.386 |
|
| 2017 |
Florez JC. Pharmacogenetics in type 2 diabetes: precision medicine or discovery tool? Diabetologia. PMID 28283684 DOI: 10.1007/S00125-017-4227-1 |
0.479 |
|
| 2017 |
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, Rüeger S, Thorleifsson G, Justice AE, Lamparter D, Stirrups KE, ... ... Florez JC, et al. Rare and low-frequency coding variants alter human adult height. Nature. PMID 28146470 DOI: 10.1038/Nature21039 |
0.366 |
|
| 2016 |
Florez JC. Genetics of Diabetic Kidney Disease. Seminars in Nephrology. 36: 474-480. PMID 27987549 DOI: 10.1016/J.Semnephrol.2016.09.012 |
0.425 |
|
| 2016 |
Varga TV, Winters AH, Jablonski KA, Horton ES, Khare-Ranade P, Knowler WC, Marcovina SM, Renström F, Watson KE, Goldberg R, Florez JC, Pollin TI, Franks PW. Comprehensive Analysis of Established Dyslipidemia-Associated Loci in the Diabetes Prevention Program. Circulation. Cardiovascular Genetics. PMID 27784733 DOI: 10.1161/Circgenetics.116.001457 |
0.395 |
|
| 2016 |
Majithia AR, Tsuda B, Agostini M, Gnanapradeepan K, Rice R, Peloso G, Patel KA, Zhang X, Broekema MF, Patterson N, Duby M, Sharpe T, Kalkhoven E, Rosen ED, Barroso I, ... ... Florez JC, et al. Prospective functional classification of all possible missense variants in PPARG. Nature Genetics. PMID 27749844 DOI: 10.1038/Ng.3700 |
0.37 |
|
| 2016 |
Sandholm N, Van Zuydam N, Ahlqvist E, Juliusdottir T, Deshmukh HA, Rayner NW, Di Camillo B, Forsblom C, Fadista J, Ziemek D, Salem RM, Hiraki LT, Pezzolesi M, Trégouët D, Dahlström E, ... ... Florez JC, et al. The Genetic Landscape of Renal Complications in Type 1 Diabetes. Journal of the American Society of Nephrology : Jasn. PMID 27647854 DOI: 10.1681/Asn.2016020231 |
0.481 |
|
| 2016 |
Chen BH, Hivert MF, Peters MJ, Pilling LC, Hogan JD, Pham LM, Harries LW, Fox CS, Bandinelli S, Dehghan A, Hernandez DG, Hofman A, Hong J, Joehanes R, Johnson AD, ... ... Florez JC, et al. Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations. Diabetes. PMID 27625022 DOI: 10.2337/Db16-0470 |
0.398 |
|
| 2016 |
McCaffery JM, Jablonski KA, Franks PW, Delahanty LM, Aroda V, Marrero D, Hamman RF, Horton ES, Dagogo-Jack S, Wylie-Rosett J, Barrett-Connor E, Kitabchi A, Knowler WC, Wing RR, Florez JC, et al. Replication of the Association of BDNF and MC4R Variants With Dietary Intake in the Diabetes Prevention Program. Psychosomatic Medicine. PMID 27551991 DOI: 10.1097/Psy.0000000000000380 |
0.371 |
|
| 2016 |
Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E, Fennell T, O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T, Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K, ... ... Florez JC, et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 536: 285-291. PMID 27535533 DOI: 10.1038/Nature19057 |
0.329 |
|
| 2016 |
Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, ... ... Florez JC, et al. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nature Genetics. PMID 27500523 DOI: 10.1038/Ng.3632 |
0.37 |
|
| 2016 |
Florez JC. Leveraging Genetics to Advance Type 2 Diabetes Prevention. Plos Medicine. 13: e1002102. PMID 27458973 DOI: 10.1371/Journal.Pmed.1002102 |
0.437 |
|
| 2016 |
Rhee EP, Yang Q, Yu B, Liu X, Cheng S, Deik A, Pierce KA, Bullock K, Ho JE, Levy D, Florez JC, Kathiresan S, Larson MG, Vasan RS, Clish CB, et al. An exome array study of the plasma metabolome. Nature Communications. 7: 12360. PMID 27453504 DOI: 10.1038/Ncomms12360 |
0.373 |
|
| 2016 |
Walford GA, Gustafsson S, Rybin D, Stančáková A, Chen H, Liu CT, Hong J, Jensen RA, Rice K, Morris AP, Mägi R, Tönjes A, Prokopenko I, Kleber ME, Delgado G, ... ... Florez JC, et al. Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci. Diabetes. PMID 27416945 DOI: 10.2337/Db16-0199 |
0.375 |
|
| 2016 |
Flannick J, Florez JC. Type 2 diabetes: genetic data sharing to advance complex disease research. Nature Reviews. Genetics. PMID 27402621 DOI: 10.1038/Nrg.2016.56 |
0.453 |
|
| 2016 |
Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, ... ... Florez JC, et al. The genetic architecture of type 2 diabetes. Nature. PMID 27398621 DOI: 10.1038/Nature18642 |
0.472 |
|
| 2016 |
Piccolo RS, Subramanian SV, Pearce N, Florez JC, McKinlay JB. Relative Contributions of Socioeconomic, Local Environmental, Psychosocial, Lifestyle/Behavioral, Biophysiological, and Ancestral Factors to Racial/Ethnic Disparities in Type 2 Diabetes. Diabetes Care. 39: 1208-17. PMID 27330127 DOI: 10.2337/Dc15-2255 |
0.387 |
|
| 2016 |
Liu CT, Raghavan S, Maruthur N, Kabagambe EK, Hong J, Ng MC, Hivert MF, Lu Y, An P, Bentley AR, Drolet AM, Gaulton KJ, Guo X, Armstrong LL, Irvin MR, ... ... Florez JC, et al. Trans-ethnic Meta-Analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. American Journal of Human Genetics. PMID 27321945 DOI: 10.1016/J.Ajhg.2016.05.006 |
0.46 |
|
| 2016 |
Florez JC. Precision Medicine in Diabetes: Is It Time? Diabetes Care. PMID 27289125 DOI: 10.2337/Dc16-0586 |
0.442 |
|
| 2016 |
Hall KT, Jablonski KA, Chen L, Harden M, Tolkin BR, Kaptchuk TJ, Bray GA, Ridker PM, Florez JC, Mukamal KJ, Chasman DI. Catechol-O-methyltransferase association with hemoglobin A1c. Metabolism: Clinical and Experimental. 65: 961-7. PMID 27282867 DOI: 10.1016/J.Metabol.2016.04.001 |
0.389 |
|
| 2016 |
Powe CE, Allard C, Battista MC, Doyon M, Bouchard L, Ecker JL, Perron P, Florez JC, Thadhani R, Hivert MF. Heterogeneous Contribution of Insulin Sensitivity and Secretion Defects to Gestational Diabetes Mellitus. Diabetes Care. PMID 27208340 DOI: 10.2337/Dc15-2672 |
0.436 |
|
| 2016 |
Horikoshi M, Pasquali L, Wiltshire S, Huyghe JR, Mahajan A, Asimit JL, Ferreira T, Locke AE, Robertson NR, Wang X, Sim X, Fujita H, Hara K, Young R, Zhang W, ... ... Florez JC, et al. Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Human Molecular Genetics. PMID 26911676 DOI: 10.1093/Hmg/Ddw048 |
0.426 |
|
| 2016 |
Florez JC. Found in Translation: A Type 1 Diabetes Genetic Risk Score Applied to Clinical Diagnosis. Diabetes Care. 39: 330-2. PMID 26908929 DOI: 10.2337/Dci15-0029 |
0.405 |
|
| 2016 |
Leong A, Porneala B, Dupuis J, Florez JC, Meigs JB. Type 2 Diabetes Genetic Predisposition, Obesity, and All-Cause Mortality Risk in the U.S.: A Multiethnic Analysis. Diabetes Care. PMID 26884474 DOI: 10.2337/Dc15-2080 |
0.427 |
|
| 2016 |
Walford GA, Ma Y, Clish C, Florez JC, Wang TJ, Gerszten RE. Metabolite profiles of diabetes incidence and intervention response in the Diabetes Prevention Program. Diabetes. PMID 26861782 DOI: 10.2337/Db15-1063 |
0.461 |
|
| 2016 |
Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N, Zhao W, Wang X, Huerta-Chagoya A, Hu C, Moon S, Long J, Kwak SH, Rasheed A, Saxena R, ... ... Florez JC, et al. Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications. 7: 10531. PMID 26818947 DOI: 10.1038/Ncomms10531 |
0.404 |
|
| 2016 |
Fadista J, Manning AK, Florez JC, Groop L. The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants. European Journal of Human Genetics : Ejhg. PMID 26733288 DOI: 10.1038/Ejhg.2015.269 |
0.415 |
|
| 2016 |
Todd JN, Salem R, Sandholm N, Valo EA, Hiraki LT, Liao CD, Pezzolesi MG, Smiles A, Onengut-Gumuscu S, Chen WM, McGurnaghan S, McKeigue P, McKnight AJ, Maxwell AP, Colhoun HM, ... ... Florez JC, et al. Novel Genetic Determinants of Diabetic Kidney Disease Diabetes. 65. DOI: 10.2337/Db16-1-381 |
0.431 |
|
| 2015 |
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, William Rayner N, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, ... ... Florez JC, et al. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics. PMID 26551672 DOI: 10.1038/Ng.3437 |
0.434 |
|
| 2015 |
Hivert MF, Christophi CA, Franks PW, Jablonski KA, Ehrmann DA, Kahn SE, Horton ES, Pollin TI, Mather KJ, Perreault L, Barrett-Connor E, Knowler WC, Florez JC. Lifestyle and metformin ameliorate insulin sensitivity independently of the genetic burden of established insulin resistance variants in Diabetes Prevention Program participants. Diabetes. PMID 26525880 DOI: 10.2337/Db15-0950 |
0.422 |
|
| 2015 |
Todd JN, Dahlström EH, Salem RM, Sandholm N, Forsblom C, McKnight AJ, Maxwell AP, Brennan E, Sadlier D, Godson C, Groop PH, Hirschhorn JN, Florez JC. Genetic Evidence for a Causal Role of Obesity in Diabetic Kidney Disease. Diabetes. PMID 26307587 DOI: 10.2337/Db15-0254 |
0.388 |
|
| 2015 |
Papandonatos GD, Pan Q, Pajewski NM, Delahanty LM, Peter I, Erar B, Ahmad S, Harden M, Chen L, Fontanillas P, Wagenknecht LE, Kahn SE, Wing RR, Jablonski KA, ... ... Florez JC, et al. Genetic predisposition to weight loss & regain with lifestyle intervention: analyses from the Diabetes Prevention Program & the Look AHEAD randomized controlled trials. Diabetes. PMID 26253612 DOI: 10.2337/Db15-0441 |
0.382 |
|
| 2015 |
Mather KM, Kim C, Christophi CA, Aroda VR, Knowler WC, Edelstein SE, Florez JC, Labrie F, Kahn SE, Goldberg RB, Barrett-Connor E. Steroid sex hormones, sex hormone binding globulin and diabetes incidence in the Diabetes Prevention Program. The Journal of Clinical Endocrinology and Metabolism. jc20152328. PMID 26200237 DOI: 10.1210/Jc.2015-2328 |
0.414 |
|
| 2015 |
Srinivasan S, Florez JC. Therapeutic Challenges in Diabetes Prevention: We Have Not Found the "Exercise Pill". Clinical Pharmacology and Therapeutics. 98: 162-9. PMID 25974616 DOI: 10.1002/Cpt.146 |
0.395 |
|
| 2015 |
Walford GA, Colomo N, Todd JN, Billings LK, Fernandez M, Chamarthi B, Warner AS, Davis J, Littleton KR, Hernandez AM, Fanelli RR, Lanier A, Barbato C, Ackerman RJ, Khan SQ, ... ... Florez JC, et al. The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes. Plos One. 10: e0121553. PMID 25812009 DOI: 10.1371/Journal.Pone.0121553 |
0.461 |
|
| 2015 |
Dauriz M, Porneala BC, Guo X, Bielak LF, Peyser PA, Durant NH, Carnethon MR, Bonadonna RC, Bonora E, Bowden DW, Florez JC, Fornage M, Hivert MF, Jacobs DR, Kabagambe EK, et al. Association of a 62 Variants Type 2 Diabetes Genetic Risk Score With Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study. Circulation. Cardiovascular Genetics. 8: 507-15. PMID 25805414 DOI: 10.1161/Circgenetics.114.000740 |
0.465 |
|
| 2015 |
Renström F, Koivula RW, Varga TV, Hallmans G, Mulder H, Florez JC, Hu FB, Franks PW. Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study. Diabetologia. 58: 997-1005. PMID 25707907 DOI: 10.1007/S00125-015-3533-8 |
0.339 |
|
| 2015 |
Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert MF, Raghavan S, Lipovich L, Hidalgo B, Fox K, Huffman JE, An P, Lu Y, ... ... Florez JC, et al. Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nature Communications. 6: 5897. PMID 25631608 DOI: 10.1038/Ncomms6897 |
0.434 |
|
| 2015 |
Mahajan A, Sim X, Ng HJ, Manning A, Rivas MA, Highland HM, Locke AE, Grarup N, Im HK, Cingolani P, Flannick J, Fontanillas P, Fuchsberger C, Gaulton KJ, Teslovich TM, ... ... Florez JC, et al. Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. Plos Genetics. 11: e1004876. PMID 25625282 DOI: 10.1371/Journal.Pgen.1004876 |
0.433 |
|
| 2015 |
Segrè AV, Wei N, Altshuler D, Florez JC. Pathways targeted by antidiabetes drugs are enriched for multiple genes associated with type 2 diabetes risk. Diabetes. 64: 1470-83. PMID 25368101 DOI: 10.2337/Db14-0703 |
0.387 |
|
| 2015 |
Hamman RF, Horton E, Barrett-Connor E, Bray GA, Christophi CA, Crandall J, Florez JC, Fowler S, Goldberg R, Kahn SE, Knowler WC, Lachin JM, Murphy MB, Venditti E. Factors affecting the decline in incidence of diabetes in the Diabetes Prevention Program Outcomes Study (DPPOS). Diabetes. 64: 989-98. PMID 25277389 DOI: 10.2337/Db14-0333 |
0.399 |
|
| 2015 |
Knowler WC, Edelstein SL, Goldberg RB, Ackermann RT, Crandall JP, Florez JC, Fowler SE, Herman WH, Horton ES, Kahn SE, Mather KJ, Nathan DM. HbA1c as a predictor of diabetes and as an outcome in the diabetes prevention program: A randomized clinical trial Diabetes Care. 38: 51-58. DOI: 10.2337/Dc14-0886 |
0.435 |
|
| 2015 |
Mather K, Kim C, Christophi CA, Aroda VR, Knowler WC, Edelstein SE, Florez JC, Labrie F, Kahn SE, Goldberg RB, Barrett-Connor E. Erratum: Steroid sex hormones, sex hormone binding globulin, and diabetes incidence in the diabetes prevention program (The Journal of Clinical Endocrinology & Metabolism (2015) 100:10 (3778-3786) DOI: 10.1210/jc.2015-2328) The Journal of Clinical Endocrinology and Metabolism. 100. DOI: 10.1210/Jc.2015-3911 |
0.386 |
|
| 2014 |
Florez JC. It's not black and white: individualizing metformin treatment in type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism. 99: 3125-8. PMID 25192381 DOI: 10.1210/Jc.2014-2733 |
0.416 |
|
| 2014 |
Pawlyk AC, Giacomini KM, McKeon C, Shuldiner AR, Florez JC. Metformin pharmacogenomics: current status and future directions. Diabetes. 63: 2590-9. PMID 25060887 DOI: 10.2337/Db13-1367 |
0.394 |
|
| 2014 |
Delahanty LM, Pan Q, Jablonski KA, Aroda VR, Watson KE, Bray GA, Kahn SE, Florez JC, Perreault L, Franks PW. Effects of weight loss, weight cycling, and weight loss maintenance on diabetes incidence and change in cardiometabolic traits in the Diabetes Prevention Program. Diabetes Care. 37: 2738-45. PMID 25024396 DOI: 10.2337/Dc14-0018 |
0.383 |
|
| 2014 |
Cornes BK, Brody JA, Nikpoor N, Morrison AC, Dang HC, Ahn BS, Wang S, Dauriz M, Barzilay JI, Dupuis J, Florez JC, Coresh J, Gibbs RA, Kao WH, Liu CT, et al. Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circulation. Cardiovascular Genetics. 7: 374-82. PMID 24951664 DOI: 10.1161/Circgenetics.113.000169 |
0.345 |
|
| 2014 |
Walford GA, Porneala BC, Dauriz M, Vassy JL, Cheng S, Rhee EP, Wang TJ, Meigs JB, Gerszten RE, Florez JC. Metabolite traits and genetic risk provide complementary information for the prediction of future type 2 diabetes. Diabetes Care. 37: 2508-14. PMID 24947790 DOI: 10.2337/Dc14-0560 |
0.467 |
|
| 2014 |
Meigs JB, Grant RW, Piccolo R, López L, Florez JC, Porneala B, Marceau L, McKinlay JB. Association of African genetic ancestry with fasting glucose and HbA1c levels in non-diabetic individuals: the Boston Area Community Health (BACH) Prediabetes Study. Diabetologia. 57: 1850-8. PMID 24942103 DOI: 10.1007/S00125-014-3301-1 |
0.433 |
|
| 2014 |
Estrada K, Aukrust I, Bjørkhaug L, Burtt NP, Mercader JM, García-Ortiz H, Huerta-Chagoya A, Moreno-Macías H, Walford G, Flannick J, Williams AL, Gómez-Vázquez MJ, Fernandez-Lopez JC, Martínez-Hernández A, ... ... Florez JC, et al. Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. Jama. 311: 2305-14. PMID 24915262 DOI: 10.1001/Jama.2014.6511 |
0.417 |
|
| 2014 |
Lim S, Bae JH, Chun EJ, Kim H, Kim SY, Kim KM, Choi SH, Park KS, Florez JC, Jang HC. Differences in pancreatic volume, fat content, and fat density measured by multidetector-row computed tomography according to the duration of diabetes. Acta Diabetologica. 51: 739-48. PMID 24671510 DOI: 10.1007/S00592-014-0581-3 |
0.335 |
|
| 2014 |
Todd JN, Florez JC. An update on the pharmacogenomics of metformin: progress, problems and potential. Pharmacogenomics. 15: 529-39. PMID 24624919 DOI: 10.2217/Pgs.14.21 |
0.407 |
|
| 2014 |
Walford GA, Ma Y, Christophi CA, Goldberg RB, Jarolim P, Horton E, Mather KJ, Barrett-Connor E, Davis J, Florez JC, Wang TJ. Circulating natriuretic peptide concentrations reflect changes in insulin sensitivity over time in the Diabetes Prevention Program. Diabetologia. 57: 935-9. PMID 24554005 DOI: 10.1007/S00125-014-3183-2 |
0.369 |
|
| 2014 |
Vassy JL, Hivert MF, Porneala B, Dauriz M, Florez JC, Dupuis J, Siscovick DS, Fornage M, Rasmussen-Torvik LJ, Bouchard C, Meigs JB. Polygenic type 2 diabetes prediction at the limit of common variant detection. Diabetes. 63: 2172-82. PMID 24520119 DOI: 10.2337/Db13-1663 |
0.392 |
|
| 2014 |
Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MC, Prokopenko I, ... ... Florez JC, et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics. 46: 234-44. PMID 24509480 DOI: 10.1038/Ng.2897 |
0.459 |
|
| 2014 |
Billings LK, Jablonski KA, Ackerman RJ, Taylor A, Fanelli RR, McAteer JB, Guiducci C, Delahanty LM, Dabelea D, Kahn SE, Franks PW, Hanson RL, Maruthur NM, Shuldiner AR, Mayer-Davis EJ, ... ... Florez JC, et al. The influence of rare genetic variation in SLC30A8 on diabetes incidence and β-cell function. The Journal of Clinical Endocrinology and Metabolism. 99: E926-30. PMID 24471563 DOI: 10.1210/Jc.2013-2378 |
0.506 |
|
| 2014 |
Florez JC. Insights from monogenic diabetes and glycemic treatment goals for common types of diabetes. Jama. 311: 249-51. PMID 24430318 DOI: 10.1001/Jama.2013.283981 |
0.456 |
|
| 2014 |
Williams AL, Jacobs SB, Moreno-Macías H, Huerta-Chagoya A, Churchhouse C, Márquez-Luna C, García-Ortíz H, Gómez-Vázquez MJ, Burtt NP, Aguilar-Salinas CA, González-Villalpando C, Florez JC, Orozco L, Haiman CA, et al. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature. 506: 97-101. PMID 24390345 DOI: 10.1038/Nature12828 |
0.506 |
|
| 2014 |
Franks PW, Christophi CA, Jablonski KA, Billings LK, Delahanty LM, Horton ES, Knowler WC, Florez JC. Common variation at PPARGC1A/B and change in body composition and metabolic traits following preventive interventions: the Diabetes Prevention Program. Diabetologia. 57: 485-90. PMID 24317794 DOI: 10.1007/S00125-013-3133-4 |
0.426 |
|
| 2014 |
Dimas AS, Lagou V, Barker A, Knowles JW, Mägi R, Hivert MF, Benazzo A, Rybin D, Jackson AU, Stringham HM, Song C, Fischer-Rosinsky A, Boesgaard TW, Grarup N, Abbasi FA, ... ... Florez JC, et al. Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes. 63: 2158-71. PMID 24296717 DOI: 10.2337/Db13-0949 |
0.446 |
|
| 2014 |
Sullivan SD, Jablonski KA, Florez JC, Dabelea D, Franks PW, Dagogo-Jack S, Kim C, Knowler WC, Christophi CA, Ratner R. Genetic risk of progression to type 2 diabetes and response to intensive lifestyle or metformin in prediabetic women with and without a history of gestational diabetes mellitus. Diabetes Care. 37: 909-11. PMID 24271189 DOI: 10.2337/Dc13-0700 |
0.437 |
|
| 2013 |
Prudente S, Copetti M, Morini E, Mendonca C, Andreozzi F, Chandalia M, Baratta R, Pellegrini F, Mercuri L, Bailetti D, Abate N, Frittitta L, Sesti G, Florez JC, et al. The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry. Nutrition, Metabolism, and Cardiovascular Diseases : Nmcd. 23: 1043-9. PMID 24103803 DOI: 10.1016/J.Numecd.2013.05.001 |
0.391 |
|
| 2013 |
Flannick J, Beer NL, Bick AG, Agarwala V, Molnes J, Gupta N, Burtt NP, Florez JC, Meigs JB, Taylor H, Lyssenko V, Irgens H, Fox E, Burslem F, Johansson S, et al. Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nature Genetics. 45: 1380-5. PMID 24097065 DOI: 10.1038/Ng.2794 |
0.393 |
|
| 2013 |
Wang TJ, Ngo D, Psychogios N, Dejam A, Larson MG, Vasan RS, Ghorbani A, O'Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox CS, O'Donnell CJ, Ho JE, ... Florez JC, et al. 2-Aminoadipic acid is a biomarker for diabetes risk. The Journal of Clinical Investigation. 123: 4309-17. PMID 24091325 DOI: 10.1172/Jci64801 |
0.453 |
|
| 2013 |
Fesinmeyer MD, Meigs JB, North KE, Schumacher FR, Bůžková P, Franceschini N, Haessler J, Goodloe R, Spencer KL, Voruganti VS, Howard BV, Jackson R, Kolonel LN, Liu S, Manson JE, ... ... Florez JC, et al. Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. Bmc Medical Genetics. 14: 98. PMID 24063630 DOI: 10.1186/1471-2350-14-98 |
0.401 |
|
| 2013 |
Sandholm N, McKnight AJ, Salem RM, Brennan EP, Forsblom C, Harjutsalo V, Mäkinen VP, McKay GJ, Sadlier DM, Williams WW, Martin F, Panduru NM, Tarnow L, Tuomilehto J, Tryggvason K, ... ... Florez JC, et al. Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes. Journal of the American Society of Nephrology : Jasn. 24: 1537-43. PMID 24029427 DOI: 10.1681/Asn.2012111122 |
0.477 |
|
| 2013 |
Florez JC. Pharmacogenetic perturbations in humans as a tool to generate mechanistic insight. Diabetes. 62: 3019-21. PMID 23970522 DOI: 10.2337/Db13-0871 |
0.421 |
|
| 2013 |
Walford GA, Davis J, Warner AS, Ackerman RJ, Billings LK, Chamarthi B, Fanelli RR, Hernandez AM, Huang C, Khan SQ, Littleton KR, Lo J, McCarthy RM, Rhee EP, Deik A, ... ... Florez JC, et al. Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus. Metabolism: Clinical and Experimental. 62: 1772-8. PMID 23953891 DOI: 10.1016/J.Metabol.2013.07.003 |
0.374 |
|
| 2013 |
Rhee EP, Ho JE, Chen MH, Shen D, Cheng S, Larson MG, Ghorbani A, Shi X, Helenius IT, O'Donnell CJ, Souza AL, Deik A, Pierce KA, Bullock K, Walford GA, ... ... Florez JC, et al. A genome-wide association study of the human metabolome in a community-based cohort. Cell Metabolism. 18: 130-43. PMID 23823483 DOI: 10.1016/J.Cmet.2013.06.013 |
0.342 |
|
| 2013 |
Ezzat S, Zheng L, Florez JC, Stefan N, Mayr T, Hliang MM, Jablonski K, Harden M, StanÄáková A, Laakso M, Haring HU, Ullrich A, Asa SL. The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes. Cell Metabolism. 17: 929-40. PMID 23747250 DOI: 10.1016/J.Cmet.2013.05.002 |
0.399 |
|
| 2013 |
Lim S, Hong J, Liu CT, Hivert MF, White CC, Murabito JM, O'Donnell CJ, Dupuis J, Florez JC, Meigs JB. Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study. Atherosclerosis. 229: 149-54. PMID 23659870 DOI: 10.1016/J.Atherosclerosis.2013.03.037 |
0.371 |
|
| 2013 |
Franks PW, Christophi CA, Jablonski KA, Delahanty LM, Horton ES, Knowler WC, Florez JC. RETRACTED ARTICLE: Common variation in PPARGC1A/B and progression to diabetes or change in metabolic traits following preventive interventions: the Diabetes Prevention Program Diabetologia. 56: 2102-2102. PMID 23616238 DOI: 10.1007/S00125-013-2911-3 |
0.501 |
|
| 2013 |
Franks PW, Pearson E, Florez JC. Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects. Diabetes Care. 36: 1413-21. PMID 23613601 DOI: 10.2337/Dc12-2211 |
0.436 |
|
| 2013 |
Pan Q, Delahanty LM, Jablonski KA, Knowler WC, Kahn SE, Florez JC, Franks PW. Variation at the melanocortin 4 receptor gene and response to weight-loss interventions in the diabetes prevention program. Obesity (Silver Spring, Md.). 21: E520-6. PMID 23512951 DOI: 10.1002/Oby.20459 |
0.398 |
|
| 2013 |
de Miguel-Yanes JM, Porneala B, Pencina MJ, Fox CS, Florez JC, Siscovick DS, Dupuis J, Meigs JB. Lack of interaction of beta-cell-function-associated variants with hypertension on change in fasting glucose and diabetes risk: the Framingham Offspring Study. Journal of Hypertension. 31: 1001-9. PMID 23425704 DOI: 10.1097/Hjh.0B013E32835F5A83 |
0.404 |
|
| 2013 |
Ho JE, Larson MG, Vasan RS, Ghorbani A, Cheng S, Rhee EP, Florez JC, Clish CB, Gerszten RE, Wang TJ. Metabolite profiles during oral glucose challenge. Diabetes. 62: 2689-98. PMID 23382451 DOI: 10.2337/Db12-0754 |
0.311 |
|
| 2013 |
Grant RW, O'Brien KE, Waxler JL, Vassy JL, Delahanty LM, Bissett LG, Green RC, Stember KG, Guiducci C, Park ER, Florez JC, Meigs JB. Personalized genetic risk counseling to motivate diabetes prevention: a randomized trial. Diabetes Care. 36: 13-9. PMID 22933432 DOI: 10.2337/Dc12-0884 |
0.447 |
|
| 2013 |
Florez JC. Diabetes Genomic and Personalized Medicine. 2: 990-1005. DOI: 10.1016/B978-0-12-382227-7.00082-3 |
0.306 |
|
| 2012 |
Mercader JM, Puiggros M, Segrè AV, Planet E, Sorianello E, Sebastian D, Rodriguez-Cuenca S, Ribas V, Bonà s-Guarch S, Draghici S, Yang C, Mora S, Vidal-Puig A, Dupuis J, ... Florez JC, et al. Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems. Plos Genetics. 8: e1003046. PMID 23236286 DOI: 10.1371/Journal.Pgen.1003046 |
0.42 |
|
| 2012 |
Sandholm N, Salem RM, McKnight AJ, Brennan EP, Forsblom C, Isakova T, McKay GJ, Williams WW, Sadlier DM, Mäkinen VP, Swan EJ, Palmer C, Boright AP, Ahlqvist E, Deshmukh HA, ... ... Florez JC, et al. New susceptibility loci associated with kidney disease in type 1 diabetes. Plos Genetics. 8: e1002921. PMID 23028342 DOI: 10.1371/Journal.Pgen.1002921 |
0.462 |
|
| 2012 |
Florez JC, Jablonski KA, McAteer JB, Franks PW, Mason CC, Mather K, Horton E, Goldberg R, Dabelea D, Kahn SE, Arakaki RF, Shuldiner AR, Knowler WC. Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program. Plos One. 7: e44424. PMID 22984506 DOI: 10.1371/Journal.Pone.0044424 |
0.503 |
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| 2012 |
Pollin TI, Isakova T, Jablonski KA, de Bakker PI, Taylor A, McAteer J, Pan Q, Horton ES, Delahanty LM, Altshuler D, Shuldiner AR, Goldberg RB, Florez JC, Franks PW. Genetic modulation of lipid profiles following lifestyle modification or metformin treatment: the Diabetes Prevention Program. Plos Genetics. 8: e1002895. PMID 22951888 DOI: 10.1371/Journal.Pgen.1002895 |
0.358 |
|
| 2012 |
Liu CT, Ng MC, Rybin D, Adeyemo A, Bielinski SJ, Boerwinkle E, Borecki I, Cade B, Chen YD, Djousse L, Fornage M, Goodarzi MO, Grant SF, Guo X, Harris T, ... ... Florez JC, et al. Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource. Diabetologia. 55: 2970-84. PMID 22893027 DOI: 10.1007/S00125-012-2656-4 |
0.382 |
|
| 2012 |
Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Shungin D, ... ... Florez JC, et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics. 44: 991-1005. PMID 22885924 DOI: 10.1038/Ng.2385 |
0.479 |
|
| 2012 |
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, Prokopenko I, Kang HM, Dina C, Esko T, Fraser RM, ... ... Florez JC, et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics. 44: 981-90. PMID 22885922 DOI: 10.1038/Ng.2383 |
0.492 |
|
| 2012 |
Florez JC, Jablonski KA, Taylor A, Mather K, Horton E, White NH, Barrett-Connor E, Knowler WC, Shuldiner AR, Pollin TI. The C allele of ATM rs11212617 does not associate with metformin response in the Diabetes Prevention Program. Diabetes Care. 35: 1864-7. PMID 22751958 DOI: 10.2337/Dc11-2301 |
0.461 |
|
| 2012 |
Williams WW, Salem RM, McKnight AJ, Sandholm N, Forsblom C, Taylor A, Guiducci C, McAteer JB, McKay GJ, Isakova T, Brennan EP, Sadlier DM, Palmer C, Söderlund J, Fagerholm E, ... ... Florez JC, et al. Association testing of previously reported variants in a large case-control meta-analysis of diabetic nephropathy. Diabetes. 61: 2187-94. PMID 22721967 DOI: 10.2337/Db11-0751 |
0.482 |
|
| 2012 |
Billings LK, Hsu YH, Ackerman RJ, Dupuis J, Voight BF, Rasmussen-Torvik LJ, Hercberg S, Lathrop M, Barnes D, Langenberg C, Hui J, Fu M, Bouatia-Naji N, Lecoeur C, An P, ... ... Florez JC, et al. Impact of common variation in bone-related genes on type 2 diabetes and related traits. Diabetes. 61: 2176-86. PMID 22698912 DOI: 10.2337/Db11-1515 |
0.493 |
|
| 2012 |
Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, ... ... Florez JC, et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature Genetics. 44: 659-69. PMID 22581228 DOI: 10.1038/Ng.2274 |
0.42 |
|
| 2012 |
Grimsby JL, Porneala BC, Vassy JL, Yang Q, Florez JC, Dupuis J, Liu T, Yesupriya A, Chang MH, Ned RM, Dowling NF, Khoury MJ, Meigs JB. Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III). Bmc Medical Genetics. 13: 30. PMID 22540250 DOI: 10.1186/1471-2350-13-30 |
0.398 |
|
| 2012 |
Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, ... ... Florez JC, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. Plos Genetics. 8: e1002607. PMID 22479202 DOI: 10.1371/Journal.Pgen.1002607 |
0.417 |
|
| 2012 |
Haiman CA, Fesinmeyer MD, Spencer KL, Buzková P, Voruganti VS, Wan P, Haessler J, Franceschini N, Monroe KR, Howard BV, Jackson RD, Florez JC, Kolonel LN, Buyske S, Goodloe RJ, et al. Consistent directions of effect for established type 2 diabetes risk variants across populations: the population architecture using Genomics and Epidemiology (PAGE) Consortium. Diabetes. 61: 1642-7. PMID 22474029 DOI: 10.2337/Db11-1296 |
0.425 |
|
| 2012 |
Mather KJ, Christophi CA, Jablonski KA, Knowler WC, Goldberg RB, Kahn SE, Spector T, Dastani Z, Waterworth D, Richards JB, Funahashi T, Pi-Sunyer FX, Pollin TI, Florez JC, Franks PW, et al. Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program. Diabetic Medicine : a Journal of the British Diabetic Association. 29: 1579-88. PMID 22443353 DOI: 10.1111/J.1464-5491.2012.03662.X |
0.438 |
|
| 2012 |
Scott RA, Chu AY, Grarup N, Manning AK, Hivert MF, Shungin D, Tönjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, ... ... Florez JC, et al. No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes. 61: 1291-6. PMID 22415877 DOI: 10.2337/Db11-0973 |
0.402 |
|
| 2012 |
Waxler JL, O'Brien KE, Delahanty LM, Meigs JB, Florez JC, Park ER, Pober BR, Grant RW. Genetic counseling as a tool for type 2 diabetes prevention: a genetic counseling framework for common polygenetic disorders. Journal of Genetic Counseling. 21: 684-91. PMID 22302620 DOI: 10.1007/S10897-012-9486-X |
0.459 |
|
| 2012 |
Vassy JL, O'Brien KE, Waxler JL, Park ER, Delahanty LM, Florez JC, Meigs JB, Grant RW. Impact of literacy and numeracy on motivation for behavior change after diabetes genetic risk testing. Medical Decision Making : An International Journal of the Society For Medical Decision Making. 32: 606-15. PMID 22247420 DOI: 10.1177/0272989X11431608 |
0.449 |
|
| 2012 |
Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP, Ferrara A, ... ... Florez JC, et al. A genome-wide association search for type 2 diabetes genes in African Americans. Plos One. 7: e29202. PMID 22238593 DOI: 10.1371/Journal.Pone.0029202 |
0.416 |
|
| 2012 |
Delahanty LM, Pan Q, Jablonski KA, Watson KE, McCaffery JM, Shuldiner A, Kahn SE, Knowler WC, Florez JC, Franks PW. Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. Diabetes Care. 35: 363-6. PMID 22179955 DOI: 10.2337/Dc11-1328 |
0.341 |
|
| 2012 |
Walford GA, Green T, Neale B, Isakova T, Rotter JI, Grant SF, Fox CS, Pankow JS, Wilson JG, Meigs JB, Siscovick DS, Bowden DW, Daly MJ, Florez JC. Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism. Diabetologia. 55: 331-9. PMID 22038522 DOI: 10.1007/S00125-011-2353-8 |
0.432 |
|
| 2011 |
Huang C, Florez JC. Pharmacogenetics in type 2 diabetes: potential implications for clinical practice. Genome Medicine. 3: 76. PMID 22126607 DOI: 10.1186/Gm292 |
0.472 |
|
| 2011 |
Grant RW, Meigs JB, Florez JC, Park ER, Green RC, Waxler JL, Delahanty LM, O'Brien KE. Design of a randomized trial of diabetes genetic risk testing to motivate behavior change: the Genetic Counseling/lifestyle Change (GC/LC) Study for Diabetes Prevention. Clinical Trials (London, England). 8: 609-15. PMID 22013171 DOI: 10.1177/1740774511414159 |
0.456 |
|
| 2011 |
Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, ... ... Florez JC, et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes. 60: 2624-34. PMID 21873549 DOI: 10.2337/Db11-0415 |
0.463 |
|
| 2011 |
Vassy JL, Shrader P, Yang Q, Liu T, Yesupriya A, Chang MH, Dowling NF, Ned RM, Dupuis J, Florez JC, Khoury MJ, Meigs JB. Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States. Metabolic Syndrome and Related Disorders. 9: 475-82. PMID 21848424 DOI: 10.1089/Met.2011.0021 |
0.351 |
|
| 2011 |
McCaffery JM, Jablonski KA, Franks PW, Dagogo-Jack S, Wing RR, Knowler WC, Delahanty L, Dabelea D, Hamman R, Shuldiner AR, Florez JC. TCF7L2 polymorphism, weight loss and proinsulin:insulin ratio in the diabetes prevention program. Plos One. 6: e21518. PMID 21814547 DOI: 10.1371/Journal.Pone.0021518 |
0.443 |
|
| 2011 |
Kanoni S, Nettleton JA, Hivert MF, Ye Z, van Rooij FJ, Shungin D, Sonestedt E, Ngwa JS, Wojczynski MK, Lemaitre RN, Gustafsson S, Anderson JS, Tanaka T, Hindy G, Saylor G, ... ... Florez JC, et al. Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis. Diabetes. 60: 2407-16. PMID 21810599 DOI: 10.2337/Db11-0176 |
0.362 |
|
| 2011 |
Majithia AR, Jablonski KA, McAteer JB, Mather KJ, Goldberg RB, Kahn SE, Florez JC. Association of the SLC30A8 missense polymorphism R325W with proinsulin levels at baseline and after lifestyle, metformin or troglitazone intervention in the Diabetes Prevention Program. Diabetologia. 54: 2570-4. PMID 21779873 DOI: 10.1007/S00125-011-2234-1 |
0.49 |
|
| 2011 |
de Miguel-Yanes JM, Manning AK, Shrader P, McAteer JB, Goel A, Hamsten A, Fox CS, Florez JC, Dupuis J, Meigs JB. Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease. Obesity (Silver Spring, Md.). 19: 2031-7. PMID 21633404 DOI: 10.1038/Oby.2011.135 |
0.452 |
|
| 2011 |
Pollin TI, Jablonski KA, McAteer JB, Saxena R, Kathiresan S, Kahn SE, Goldberg RB, Altshuler D, Florez JC. Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism. The Journal of Clinical Endocrinology and Metabolism. 96: E1142-7. PMID 21525158 DOI: 10.1210/Jc.2010-2324 |
0.422 |
|
| 2011 |
Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, et al. Metabolite profiles and the risk of developing diabetes. Nature Medicine. 17: 448-53. PMID 21423183 DOI: 10.1038/Nm.2307 |
0.408 |
|
| 2011 |
Rhee EP, Cheng S, Larson MG, Walford GA, Lewis GD, McCabe E, Yang E, Farrell L, Fox CS, O'Donnell CJ, Carr SA, Vasan RS, Florez JC, Clish CB, Wang TJ, et al. Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. The Journal of Clinical Investigation. 121: 1402-11. PMID 21403394 DOI: 10.1172/Jci44442 |
0.431 |
|
| 2011 |
Hivert MF, Jablonski KA, Perreault L, Saxena R, McAteer JB, Franks PW, Hamman RF, Kahn SE, Haffner S, Meigs JB, Altshuler D, Knowler WC, Florez JC. Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program. Diabetes. 60: 1340-8. PMID 21378175 DOI: 10.2337/Db10-1119 |
0.483 |
|
| 2011 |
Böger CA, Chen MH, Tin A, Olden M, Köttgen A, de Boer IH, Fuchsberger C, O'Seaghdha CM, Pattaro C, Teumer A, Liu CT, Glazer NL, Li M, O'Connell JR, Tanaka T, ... ... Florez JC, et al. CUBN is a gene locus for albuminuria. Journal of the American Society of Nephrology : Jasn. 22: 555-70. PMID 21355061 DOI: 10.1681/Asn.2010060598 |
0.51 |
|
| 2011 |
Manning AK, LaValley M, Liu CT, Rice K, An P, Liu Y, Miljkovic I, Rasmussen-Torvik L, Harris TB, Province MA, Borecki IB, Florez JC, Meigs JB, Cupples LA, Dupuis J. Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients. Genetic Epidemiology. 35: 11-8. PMID 21181894 DOI: 10.1002/Gepi.20546 |
0.365 |
|
| 2011 |
Dabelea D, Dolan LM, D'Agostino R, Hernandez AM, McAteer JB, Hamman RF, Mayer-Davis EJ, Marcovina S, Lawrence JM, Pihoker C, Florez JC. Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth. Diabetologia. 54: 535-9. PMID 21109996 DOI: 10.1007/S00125-010-1982-7 |
0.47 |
|
| 2011 |
de Miguel-Yanes JM, Shrader P, Pencina MJ, Fox CS, Manning AK, Grant RW, Dupuis J, Florez JC, D'Agostino RB, Cupples LA, Meigs JB. Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms. Diabetes Care. 34: 121-5. PMID 20889853 DOI: 10.2337/Dc10-1265 |
0.443 |
|
| 2011 |
Renström F, Shungin D, Johansson I, Florez JC, Hallmans G, Hu FB, Franks PW. Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study. Diabetes. 60: 345-54. PMID 20870969 DOI: 10.2337/Db10-0933 |
0.401 |
|
| 2011 |
Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert MF, Ngwa J, Van Rooij FJA, Sonestedt E, Wojczynski MK, Ye Z, Tanaka T, Garcia M, Anderson JS, Follis JL, Djousse L, ... ... Florez JC, et al. Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies (Diabetes Care (2010) 33 (2684-2691)) Diabetes Care. 34: 785-786. DOI: 10.2337/Dc11-Er03 |
0.408 |
|
| 2011 |
Wang TJ, Zhang F, Richards JB, Kestenbaum B, Van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, Koller DL, Peltonen L, Cooper JD, O'Reilly PF, Houston DK, Glazer NL, ... ... Florez JC, et al. Common genetic determinants of vitamin D insufficiency: A genome-wide association study Obstetrical and Gynecological Survey. 66: 91-93. DOI: 10.1097/Ogx.0B013E318216B03D |
0.302 |
|
| 2010 |
Billings LK, Florez JC. The genetics of type 2 diabetes: what have we learned from GWAS? Annals of the New York Academy of Sciences. 1212: 59-77. PMID 21091714 DOI: 10.1111/J.1749-6632.2010.05838.X |
0.48 |
|
| 2010 |
Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS, Heeney MM, Devaney JM, Reilly MP, Ricketts SL, ... ... Florez JC, et al. Common variants at 10 genomic loci influence hemoglobin Aâ‚(C) levels via glycemic and nonglycemic pathways. Diabetes. 59: 3229-39. PMID 20858683 DOI: 10.2337/Db10-0502 |
0.412 |
|
| 2010 |
Yang Q, Liu T, Shrader P, Yesupriya A, Chang MH, Dowling NF, Ned RM, Dupuis J, Florez JC, Khoury MJ, Meigs JB. Racial/ethnic differences in association of fasting glucose-associated genomic loci with fasting glucose, HOMA-B, and impaired fasting glucose in the U.S. adult population. Diabetes Care. 33: 2370-7. PMID 20805255 DOI: 10.2337/Dc10-0898 |
0.333 |
|
| 2010 |
Jablonski KA, McAteer JB, de Bakker PI, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S, Shuldiner AR, Knowler WC, Altshuler D, Florez JC. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. Diabetes. 59: 2672-81. PMID 20682687 DOI: 10.2337/Db10-0543 |
0.473 |
|
| 2010 |
Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, ... ... Florez JC, et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature Genetics. 42: 579-89. PMID 20581827 DOI: 10.1038/Ng.609 |
0.451 |
|
| 2010 |
Qi L, Cornelis MC, Kraft P, Stanya KJ, Linda Kao WH, Pankow JS, Dupuis J, Florez JC, Fox CS, Paré G, Sun Q, Girman CJ, Laurie CC, Mirel DB, Manolio TA, et al. Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Human Molecular Genetics. 19: 2706-15. PMID 20418489 DOI: 10.1093/Hmg/Ddq156 |
0.463 |
|
| 2010 |
Ingelsson E, Langenberg C, Hivert MF, Prokopenko I, Lyssenko V, Dupuis J, Mägi R, Sharp S, Jackson AU, Assimes TL, Shrader P, Knowles JW, Zethelius B, Abbasi FA, Bergman RN, ... ... Florez JC, et al. Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes. 59: 1266-75. PMID 20185807 DOI: 10.2337/Db09-1568 |
0.352 |
|
| 2010 |
Florez JC. A genome-wide association study of treated A1C: a genetic needle in an environmental haystack? Diabetes. 59: 332-4. PMID 20103712 DOI: 10.2337/Db09-1636 |
0.42 |
|
| 2010 |
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, ... ... Florez JC, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics. 42: 105-16. PMID 20081858 DOI: 10.1038/Ng.520 |
0.456 |
|
| 2010 |
Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, Dupuis J, Jackson AU, Kao WH, Li M, Glazer NL, Manning AK, Luan J, ... ... Florez JC, et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nature Genetics. 42: 142-8. PMID 20081857 DOI: 10.1038/Ng.521 |
0.373 |
|
| 2010 |
Heid IM, Henneman P, Hicks A, Coassin S, Winkler T, Aulchenko YS, Fuchsberger C, Song K, Hivert MF, Waterworth DM, Timpson NJ, Richards JB, Perry JR, Tanaka T, Amin N, ... ... Florez JC, et al. Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals. Atherosclerosis. 208: 412-20. PMID 20018283 DOI: 10.1016/J.Atherosclerosis.2009.11.035 |
0.344 |
|
| 2010 |
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, ... ... Florez JC, et al. Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nature Genetics. 42: 464-464. DOI: 10.1038/Ng0510-464A |
0.45 |
|
| 2010 |
Walford GA, Florez JC. Type 2 Diabetes and Genetics, 2010: Translating Knowledge into Understanding Current Cardiovascular Risk Reports. 4: 437-445. DOI: 10.1007/S12170-010-0129-1 |
0.446 |
|
| 2009 |
Florez JC. Novel genetic findings applied to the clinic in type 2 diabetes. Endocrinologãa Y Nutriciã³N : ã³Rgano De La Sociedad Espaã±Ola De Endocrinologãa Y Nutriciã³N. 56: 21-5. PMID 20629226 DOI: 10.1016/S1575-0922(09)73512-0 |
0.441 |
|
| 2009 |
Florez JC. Genetic susceptibility to type 2 diabetes and implications for therapy. Journal of Diabetes Science and Technology. 3: 690-6. PMID 20144315 DOI: 10.1177/193229680900300413 |
0.419 |
|
| 2009 |
Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, Perry JR, Tanaka T, Timpson NJ, Semple RK, Soranzo N, Song K, Rocha N, Grundberg E, Dupuis J, Florez JC, et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. Plos Genetics. 5: e1000768. PMID 20011104 DOI: 10.1371/Journal.Pgen.1000768 |
0.402 |
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| 2009 |
Grant RW, Hivert M, Pandiscio JC, Florez JC, Nathan DM, Meigs JB. The clinical application of genetic testing in type 2 diabetes: a patient and physician survey. Diabetologia. 52: 2299-305. PMID 19727660 DOI: 10.1007/S00125-009-1512-7 |
0.42 |
|
| 2009 |
Stolerman ES, Florez JC. Genomics of type 2 diabetes mellitus: implications for the clinician. Nature Reviews. Endocrinology. 5: 429-36. PMID 19564886 DOI: 10.1038/Nrendo.2009.129 |
0.498 |
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| 2009 |
Florez JC, Price AL, Campbell D, Riba L, Parra MV, Yu F, Duque C, Saxena R, Gallego N, Tello-Ruiz M, Franco L, RodrÃguez-Torres M, Villegas A, Bedoya G, Aguilar-Salinas CA, et al. Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetes. Diabetologia. 52: 1528-36. PMID 19526211 DOI: 10.1007/S00125-009-1412-X |
0.452 |
|
| 2009 |
Grant RW, Moore AF, Florez JC. Genetic architecture of type 2 diabetes: recent progress and clinical implications. Diabetes Care. 32: 1107-14. PMID 19460916 DOI: 10.2337/Dc08-2171 |
0.486 |
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| 2009 |
Florez JC. The dawn of prospective pharmacogenetic testing in type 2 diabetes. Current Diabetes Reports. 9: 95-7. PMID 19323951 DOI: 10.1007/S11892-009-0016-7 |
0.409 |
|
| 2009 |
Majithia AR, Florez JC. Clinical translation of genetic predictors for type 2 diabetes. Current Opinion in Endocrinology, Diabetes, and Obesity. 16: 100-6. PMID 19306524 DOI: 10.1097/Med.0B013E3283292354 |
0.459 |
|
| 2009 |
Stolerman ES, Manning AK, McAteer JB, Fox CS, Dupuis J, Meigs JB, Florez JC. TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study. Diabetologia. 52: 614-20. PMID 19183934 DOI: 10.1007/S00125-009-1266-2 |
0.413 |
|
| 2009 |
Lieb W, Manning AK, Florez JC, Dupuis J, Cupples LA, McAteer JB, Vasan RS, Hoffmann U, O'Donnell CJ, Meigs JB, Fox CS. Variants in the CNR1 and the FAAH genes and adiposity traits in the community. Obesity (Silver Spring, Md.). 17: 755-60. PMID 19165169 DOI: 10.1038/Oby.2008.608 |
0.341 |
|
| 2009 |
Hivert MF, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC. Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study. Diabetes. 58: 750-6. PMID 19074981 DOI: 10.2337/Db08-1339 |
0.439 |
|
| 2009 |
Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, et al. Variants in MTNR1B influence fasting glucose levels. Nature Genetics. 41: 77-81. PMID 19060907 DOI: 10.1038/Ng.290 |
0.399 |
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| 2009 |
Moore AF, Jablonski KA, Mason CC, McAteer JB, Arakaki RF, Goldstein BJ, Kahn SE, Kitabchi AE, Hanson RL, Knowler WC, Florez JC. The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program. The Journal of Clinical Endocrinology and Metabolism. 94: 449-55. PMID 19017751 DOI: 10.1210/Jc.2008-1583 |
0.469 |
|
| 2008 |
Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, Manning AK, Florez JC, Wilson PW, D'Agostino RB, Cupples LA. Genotype score in addition to common risk factors for prediction of type 2 diabetes. The New England Journal of Medicine. 359: 2208-19. PMID 19020323 DOI: 10.1056/Nejmoa0804742 |
0.444 |
|
| 2008 |
Franks PW, Jablonski KA, Delahanty LM, McAteer JB, Kahn SE, Knowler WC, Florez JC. Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program. Diabetologia. 51: 2214-23. PMID 18839134 DOI: 10.1007/S00125-008-1158-X |
0.361 |
|
| 2008 |
Florez JC. Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008. The Journal of Clinical Endocrinology and Metabolism. 93: 4633-42. PMID 18782870 DOI: 10.1210/Jc.2008-1345 |
0.495 |
|
| 2008 |
Hivert MF, Manning AK, McAteer JB, Florez JC, Dupuis J, Fox CS, O'Donnell CJ, Cupples LA, Meigs JB. Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study. Diabetes. 57: 3353-9. PMID 18776141 DOI: 10.2337/Db08-0700 |
0.457 |
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| 2008 |
Meigs JB, Manning AK, Dupuis J, Liu C, Florez JC, Cupples LA. Ordered stratification to reduce heterogeneity in linkage to diabetes-related quantitative traits. Obesity (Silver Spring, Md.). 16: 2314-22. PMID 18719643 DOI: 10.1038/Oby.2008.354 |
0.449 |
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| 2008 |
Frayling TM, Colhoun H, Florez JC. A genetic link between type 2 diabetes and prostate cancer. Diabetologia. 51: 1757-60. PMID 18696045 DOI: 10.1007/S00125-008-1114-9 |
0.418 |
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| 2008 |
Köttgen A, Hwang SJ, Rampersaud E, Coresh J, North KE, Pankow JS, Meigs JB, Florez JC, Parsa A, Levy D, Boerwinkle E, Shuldiner AR, Fox CS, Kao WH. TCF7L2 variants associate with CKD progression and renal function in population-based cohorts. Journal of the American Society of Nephrology : Jasn. 19: 1989-99. PMID 18650481 DOI: 10.1681/Asn.2007121291 |
0.433 |
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| 2008 |
Moore AF, Jablonski KA, McAteer JB, Saxena R, Pollin TI, Franks PW, Hanson RL, Shuldiner AR, Knowler WC, Altshuler D, Florez JC. Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program. Diabetes. 57: 2503-10. PMID 18544707 DOI: 10.2337/Db08-0284 |
0.463 |
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| 2008 |
Florez JC. Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? Diabetologia. 51: 1100-10. PMID 18504548 DOI: 10.1007/S00125-008-1025-9 |
0.48 |
|
| 2008 |
Crandall JP, Knowler WC, Kahn SE, Marrero D, Florez JC, Bray GA, Haffner SM, Hoskin M, Nathan DM. The prevention of type 2 diabetes. Nature Clinical Practice. Endocrinology & Metabolism. 4: 382-93. PMID 18493227 DOI: 10.1038/Ncpendmet0843 |
0.431 |
|
| 2008 |
Stolerman ES, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC. Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study. Diabetes. 57: 1971-7. PMID 18426862 DOI: 10.2337/Db08-0266 |
0.408 |
|
| 2008 |
McAteer JB, Prudente S, Bacci S, Lyon HN, Hirschhorn JN, Trischitta V, Florez JC. The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects. Diabetes. 57: 1125-30. PMID 18071025 DOI: 10.2337/Db07-1336 |
0.483 |
|
| 2008 |
Florez JC, Jablonski KA, McAteer J, Sandhu MS, Wareham NJ, Barroso I, Franks PW, Altshuler D, Knowler WC. Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program. Diabetologia. 51: 451-7. PMID 18060660 DOI: 10.1007/S00125-007-0891-X |
0.457 |
|
| 2008 |
Moore AF, Florez JC. Genetic susceptibility to type 2 diabetes and implications for antidiabetic therapy. Annual Review of Medicine. 59: 95-111. PMID 17937592 DOI: 10.1146/Annurev.Med.59.090706.135315 |
0.494 |
|
| 2007 |
Meigs JB, Manning AK, Fox CS, Florez JC, Liu C, Cupples LA, Dupuis J. Genome-wide association with diabetes-related traits in the Framingham Heart Study. Bmc Medical Genetics. 8: S16. PMID 17903298 DOI: 10.1186/1471-2350-8-S1-S16 |
0.488 |
|
| 2007 |
Franks PW, Jablonski KA, Delahanty L, Hanson RL, Kahn SE, Altshuler D, Knowler WC, Florez JC. The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program. Diabetologia. 50: 2451-60. PMID 17898990 DOI: 10.1007/S00125-007-0826-6 |
0.336 |
|
| 2007 |
Tsao H, Florez JC. Introduction to genetic association studies. The Journal of Investigative Dermatology. 127: 2283-7. PMID 17853910 DOI: 10.1038/Sj.Jid.5701054 |
0.346 |
|
| 2007 |
Florez JC, Manning AK, Dupuis J, McAteer J, Irenze K, Gianniny L, Mirel DB, Fox CS, Cupples LA, Meigs JB. A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets. Diabetes. 56: 3063-74. PMID 17848626 DOI: 10.2337/Db07-0451 |
0.43 |
|
| 2007 |
Florez JC. The new type 2 diabetes gene TCF7L2. Current Opinion in Clinical Nutrition and Metabolic Care. 10: 391-6. PMID 17563454 DOI: 10.1097/Mco.0B013E3281E2C9Be |
0.492 |
|
| 2007 |
Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, ... Florez JC, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (New York, N.Y.). 316: 1331-6. PMID 17463246 DOI: 10.1126/Science.1142358 |
0.452 |
|
| 2007 |
Florez JC, Sjögren M, Agapakis CM, Burtt NP, Almgren P, Lindblad U, Berglund G, Tuomi T, Gaudet D, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, Groop L. Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes. Diabetologia. 50: 1209-17. PMID 17443311 DOI: 10.1007/S00125-007-0657-5 |
0.426 |
|
| 2007 |
Florez JC, Jablonski KA, Kahn SE, Franks PW, Dabelea D, Hamman RF, Knowler WC, Nathan DM, Altshuler D. Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program. Diabetes. 56: 531-6. PMID 17259403 DOI: 10.2337/Db06-0966 |
0.473 |
|
| 2007 |
Florez JC, Jablonski KA, Sun MW, Bayley N, Kahn SE, Shamoon H, Hamman RF, Knowler WC, Nathan DM, Altshuler D. Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone. The Journal of Clinical Endocrinology and Metabolism. 92: 1502-9. PMID 17213274 DOI: 10.1210/Jc.2006-2275 |
0.449 |
|
| 2006 |
Florez JC, Saxena R, Winckler W, Burtt NP, Almgren P, Bengtsson Boström K, Tuomi T, Gaudet D, Ardlie KG, Daly MJ, Altshuler D, Hirschhorn JN, Groop L. The Krüppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people. Diabetes. 55: 3620-4. PMID 17130512 DOI: 10.2337/Db06-0867 |
0.483 |
|
| 2006 |
Lyon HN, Florez JC, Bersaglieri T, Saxena R, Winckler W, Almgren P, Lindblad U, Tuomi T, Gaudet D, Zhu X, Cooper R, Ardlie KG, Daly MJ, Altshuler D, Groop L, et al. Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. Diabetes. 55: 3180-4. PMID 17065359 DOI: 10.2337/Db06-0407 |
0.447 |
|
| 2006 |
Saxena R, Gianniny L, Burtt NP, Lyssenko V, Giuducci C, Sjögren M, Florez JC, Almgren P, Isomaa B, Orho-Melander M, Lindblad U, Daly MJ, Tuomi T, Hirschhorn JN, Ardlie KG, et al. Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes. 55: 2890-5. PMID 17003358 DOI: 10.2337/Db06-0381 |
0.467 |
|
| 2006 |
Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. The New England Journal of Medicine. 355: 241-50. PMID 16855264 DOI: 10.1056/Nejmoa062418 |
0.474 |
|
| 2006 |
Sun MW, Lee JY, de Bakker PI, Burtt NP, Almgren P, RÃ¥stam L, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, Altshuler D, Groop L, Florez JC. Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes. Diabetes. 55: 849-55. PMID 16505254 DOI: 10.2337/Diabetes.55.03.06.Db05-1418 |
0.498 |
|
| 2006 |
Florez JC, Wiltshire S, Agapakis CM, Burtt NP, de Bakker PI, Almgren P, Bengtsson Boström K, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, McCarthy MI, Altshuler D, Groop L. High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. Diabetes. 55: 128-35. PMID 16380485 DOI: 10.2337/Diabetes.55.01.06.Db05-0954 |
0.499 |
|
| 2005 |
Florez JC, Agapakis CM, Burtt NP, Sun M, Almgren P, RÃ¥stam L, Tuomi T, Gaudet D, Hudson TJ, Daly MJ, Ardlie KG, Hirschhorn JN, Groop L, Altshuler D. Association testing of the protein tyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7,883 people. Diabetes. 54: 1884-91. PMID 15919813 DOI: 10.2337/Diabetes.54.6.1884 |
0.492 |
|
| 2004 |
Florez JC, Sjögren M, Burtt N, Orho-Melander M, Schayer S, Sun M, Almgren P, Lindblad U, Tuomi T, Gaudet D, Hudson TJ, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, et al. Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes. Diabetes. 53: 3313-8. PMID 15561965 DOI: 10.2337/Diabetes.53.12.3313 |
0.467 |
|
| 2004 |
Florez JC. Phenotypic consequences of the peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism: the weight of the evidence in genetic association studies. The Journal of Clinical Endocrinology and Metabolism. 89: 4234-7. PMID 15356013 DOI: 10.1210/Jc.2004-1402 |
0.325 |
|
| 2004 |
Florez JC, Burtt N, de Bakker PI, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D. Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region. Diabetes. 53: 1360-8. PMID 15111507 DOI: 10.2337/Diabetes.53.5.1360 |
0.478 |
|
| 2004 |
Florez JC, Burtt N, de Bakker PW, Almgren P, Tuomi T, Holmkvist J, Gaudet D, Hudson TJ, Schaffner SF, Daly MJ, Hirschhorn JN, Groop L, Altshuler D. 42 HAPLOTYPE STRUCTURE AND ASSOCIATION OF COMMON VARIANTS IN THE GENE ENCODING THE ISLET ATP-SENSITIVE POTASSIUM CHANNEL WITH TYPE 2 DIABETES. Journal of Investigative Medicine. 52: S384.2-S384. DOI: 10.1136/Jim-52-Suppl2-116 |
0.407 |
|
| 2003 |
Florez JC, Hirschhorn J, Altshuler D. The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annual Review of Genomics and Human Genetics. 4: 257-91. PMID 14527304 DOI: 10.1146/Annurev.Genom.4.070802.110436 |
0.477 |
|
| 1996 |
Florez JC, Seidenman KJ, Barrett RK, Sangoram AM, Takahashi JS. Molecular cloning of chick pineal tryptophan hydroxylase and circadian oscillation of its mRNA levels. Brain Research. Molecular Brain Research. 42: 25-30. PMID 8915576 DOI: 10.1016/S0169-328X(96)00104-0 |
0.677 |
|
| 1996 |
Florez JC, Takahashi JS. Quantitative two-dimensional gel electrophoretic analysis of clock-controlled proteins in cultured chick pineal cells: circadian regulation of tryptophan hydroxylase. Journal of Biological Rhythms. 11: 241-57. PMID 8872596 DOI: 10.1177/074873049601100306 |
0.519 |
|
| 1996 |
Florez JC, Takahashi JS. Regulation of tryptophan hydroxylase by cyclic AMP, calcium, norepinephrine, and light in cultured chick pineal cells. Journal of Neurochemistry. 67: 242-50. PMID 8666997 DOI: 10.1046/J.1471-4159.1996.67010242.X |
0.509 |
|
| 1995 |
Florez JC, Takahashi JS. The circadian clock: from molecules to behaviour. Annals of Medicine. 27: 481-90. PMID 8519510 DOI: 10.3109/07853899709002457 |
0.517 |
|
| 1995 |
Janavs JL, Florez JC, Pierce ME, Takahashi JS. Forskolin and camptothecin induce a 30 kDa protein associated with melatonin production in Y79 human retinoblastoma cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 298-309. PMID 7823135 DOI: 10.1523/Jneurosci.15-01-00298.1995 |
0.724 |
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