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Alexander Titz, Ph.D. - Publications

Affiliations: 
1998-2004 Chemistry TU Darmstadt 
 2000-2001 Chemistry University of Bordeaux 1, France 
 2003-2004 Novartis Institutes of Biomedical Research, Basel 
 2004-2008 Pharmacy Universität Basel, Basel, Basel-Stadt, Switzerland 
 2008-2010 Biology Eidgenössische Technische Hochschule Zürich, Zürich, ZH, Switzerland 
 2010-2013 Chemistry University of Konstanz, Konstanz, Germany 
 2013- Helmholtz Institute for Pharmaceutical Research Saarland 
 2020- Chemistry Saarland University, Saarbrücken, Saarland, Germany 
Area:
Carbohydrates, Biofilms, Glycobiology, Carbohydrate Chemistry, Medicinal Chemistry, Antiinfectives
Website:
https://www.helmholtz-hips.de/en/research/teams/team/chemical-biology-of-carbohydrates/
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59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wojtczak K, Zahorska E, Murphy IJ, Koppel F, Cooke G, Titz A, Byrne JP. Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(III) glycoconjugate systems. Chemical Communications (Cambridge, England). PMID 37318770 DOI: 10.1039/d3cc02300a  0.783
2023 Leusmann S, Ménová P, Shanin E, Titz A, Rademacher C. Glycomimetics for the inhibition and modulation of lectins. Chemical Society Reviews. 52: 3663-3740. PMID 37232696 DOI: 10.1039/d2cs00954d  0.621
2022 Shanina E, Kuhaudomlarp S, Siebs E, Fuchsberger FF, Denis M, da Silva Figueiredo Celestino Gomes P, Clausen MH, Seeberger PH, Rognan D, Titz A, Imberty A, Rademacher C. Targeting undruggable carbohydrate recognition sites through focused fragment library design. Communications Chemistry. 5: 64. PMID 36697615 DOI: 10.1038/s42004-022-00679-3  0.723
2022 Meiers J, Dastbaz J, Adam S, Rasheed S, Kirsch SH, Meiser P, Gross P, Müller R, Titz A. Pineapple Lectin AcmJRL binds SARS-CoV-2 Spike Protein in a carbohydrate-dependent fashion. Chembiochem : a European Journal of Chemical Biology. PMID 36420784 DOI: 10.1002/cbic.202200463  0.799
2022 Zahorska E, Rosato F, Stober K, Kuhaudomlarp S, Meiers J, Hauck D, Reith D, Gillon E, Rox K, Imberty A, Römer W, Titz A. Neutralizing the Impact of the Virulence Factor LecA from Pseudomonas aeruginosa on Human Cells with New Glycomimetic Inhibitors. Angewandte Chemie (International Ed. in English). PMID 36398566 DOI: 10.1002/anie.202215535  0.805
2022 Mała P, Siebs E, Meiers J, Rox K, Varrot A, Imberty A, Titz A. Discovery of -β-l-Fucosyl Amides as High-Affinity Ligands for the Lectin LecB. Journal of Medicinal Chemistry. 65: 14180-14200. PMID 36256875 DOI: 10.1021/acs.jmedchem.2c01373  0.813
2022 Meiers J, Rox K, Titz A. Lectin-Targeted Prodrugs Activated by for Self-Destructive Antibiotic Release. Journal of Medicinal Chemistry. 65: 13988-14014. PMID 36201248 DOI: 10.1021/acs.jmedchem.2c01214  0.813
2022 Hoffmann C, Jourdain M, Grandjean A, Titz A, Jung G. β-Boronic Acid-Substituted Bodipy Dyes for Fluorescence Anisotropy Analysis of Carbohydrate Binding. Analytical Chemistry. PMID 35426308 DOI: 10.1021/acs.analchem.1c04654  0.336
2022 Borisova M, Balbuchta K, Lovering A, Titz A, Mayer C. NamZ1 and NamZ2 from the oral pathogen are peptidoglycan processing exo-β--acetylmuramidases with distinct substrate specificity. Journal of Bacteriology. jb0059721. PMID 35129368 DOI: 10.1128/jb.00597-21  0.367
2022 Huck BC, Thiyagarajan D, Bali A, Boese A, Besecke KFW, Hozsa C, Gieseler RK, Furch M, Carvalho-Wodarz C, Waldow F, Schwudke D, Metelkina O, Titz A, Huwer H, Schwarzkopf K, et al. Nano-in-Microparticles for Aerosol Delivery of Antibiotic-Loaded, Fucose-Derivatized, and Macrophage-Targeted Liposomes to Combat Mycobacterial Infections: In Vitro Deposition, Pulmonary Barrier Interactions, and Targeted Delivery. Advanced Healthcare Materials. e2102117. PMID 35112802 DOI: 10.1002/adhm.202102117  0.364
2022 Metelkina O, Huck B, O'Connor JS, Koch M, Manz A, Lehr CM, Titz A. Targeting extracellular lectins of with glycomimetic liposomes. Journal of Materials Chemistry. B. PMID 34985094 DOI: 10.1039/d1tb02086b  0.49
2021 Siebs E, Shanina E, Kuhaudomlarp S, da Silva Figueiredo Celestino Gomes P, Fortin C, Seeberger PH, Rognan D, Rademacher C, Imberty A, Titz A. Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA. Chembiochem : a European Journal of Chemical Biology. PMID 34788491 DOI: 10.1002/cbic.202100563  0.792
2021 Panjla A, Kaul G, Chopra S, Titz A, Verma S. Short Peptides and Their Mimetics as Potent Antibacterial Agents and Antibiotic Adjuvants. Acs Chemical Biology. PMID 34779605 DOI: 10.1021/acschembio.1c00626  0.348
2021 Wawrzinek R, Wamhoff EC, Lefebre J, Rentzsch M, Bachem G, Domeniconi G, Schulze J, Fuchsberger FF, Zhang H, Modenutti C, Schnirch L, Marti MA, Schwardt O, Bräutigam M, Guberman M, ... ... Titz A, et al. A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN. Journal of the American Chemical Society. 143: 18977-18988. PMID 34748320 DOI: 10.1021/jacs.1c07235  0.714
2021 Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo PB, Glaser P, Aigle B, Bode HB, Moreira R, Li Y, Luzhetskyy A, Medema MH, Pernodet JL, ... ... Titz A, et al. Towards the sustainable discovery and development of new antibiotics. Nature Reviews. Chemistry. 1-24. PMID 34426795 DOI: 10.1038/s41570-021-00313-1  0.373
2021 Müller M, Calvert M, Hottmann I, Kluj RM, Teufel T, Balbuchta K, Engelbrecht A, Selim KA, Xu Q, Borisova M, Titz A, Mayer C. The exo-β-N-acetylmuramidase NamZ from Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosaminidases. The Journal of Biological Chemistry. 100519. PMID 33684445 DOI: 10.1016/j.jbc.2021.100519  0.748
2020 Kuhaudomlarp S, Siebs E, Shanina E, Topin J, Joachim I, da Silva Figueiredo Celestino Gomes P, Varrot A, Rognan D, Rademacher C, Imberty A, Titz A. Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-binding Lectins. Angewandte Chemie (International Ed. in English). PMID 33314528 DOI: 10.1002/anie.202013217  0.77
2020 Meiers J, Zahorska E, Röhrig T, Hauck D, Wagner S, Titz A. Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates targeting Biofilm-associated Lectins of Pseudomonas aeruginosa. Journal of Medicinal Chemistry. PMID 32924479 DOI: 10.1021/Acs.Jmedchem.0C00856  0.775
2020 Zahorska E, Kuhaudomlarp S, Minervini S, Yousaf S, Lepsik M, Kinsinger T, Hirsch AKH, Imberty A, Titz A. A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate. Chemical Communications (Cambridge, England). PMID 32628229 DOI: 10.1039/D0Cc03490H  0.828
2020 Shanina E, Siebs E, Zhang H, Silva DV, Joachim I, Titz A, Rademacher C. Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa. Glycobiology. PMID 32573695 DOI: 10.1093/Glycob/Cwaa057  0.717
2020 Wohlschlager T, Titz A, Künzler M, Varrot A. Expression, Purification, and Functional Characterization of Tectonin 2 from Laccaria bicolor: A Six-Bladed Beta-Propeller Lectin Specific for O-Methylated Glycans. Methods in Molecular Biology (Clifton, N.J.). 2132: 669-682. PMID 32306366 DOI: 10.1007/978-1-0716-0430-4_58  0.406
2019 Siebert DCB, Sommer R, Pogorevc D, Hoffmann M, Wenzel SC, Müller R, Titz A. Chemical synthesis of tripeptide thioesters for the biotechnological incorporation into the myxobacterial secondary metabolite argyrin via mutasynthesis. Beilstein Journal of Organic Chemistry. 15: 2922-2929. PMID 31839838 DOI: 10.3762/Bjoc.15.286  0.642
2019 Sommer R, Rox K, Wagner S, Hauck D, Henrikus S, Newsad S, Arnold T, Ryckmans T, Brönstrup M, Imberty A, Varrot A, Hartmann RW, Titz A. Anti-Biofilm Agents against Pseudomonas aeruginosa: a Structure-Activity Relationship Study of C-Glycosidic LecB Inhibitors. Journal of Medicinal Chemistry. PMID 31553873 DOI: 10.1021/Acs.Jmedchem.9B01120  0.824
2019 Meiers J, Siebs E, Zahorska E, Titz A. Lectin antagonists in infection, immunity, and inflammation. Current Opinion in Chemical Biology. 53: 51-67. PMID 31470348 DOI: 10.1016/J.Cbpa.2019.07.005  0.784
2019 Lepsik M, Sommer R, Kuhaudomlarp S, Lelimousin M, Paci E, Varrot A, Titz A, Imberty A. Induction of rare conformation of oligosaccharide by binding to calcium-dependent bacterial lectin: X-ray crystallography and modelling study. European Journal of Medicinal Chemistry. 177: 212-220. PMID 31146126 DOI: 10.1016/J.Ejmech.2019.05.049  0.733
2018 Calvert MB, Jumde VR, Titz A. Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections. Beilstein Journal of Organic Chemistry. 14: 2607-2617. PMID 30410623 DOI: 10.3762/Bjoc.14.239  0.802
2018 Dingjan T, Gillon É, Imberty A, Perez S, Titz A, Ramsland PA, Yuriev E. Virtual Screening Against Carbohydrate-binding Proteins: Evaluation and Application to Bacterial Burkholderia ambifaria Lectin. Journal of Chemical Information and Modeling. PMID 30075071 DOI: 10.1021/Acs.Jcim.8B00185  0.632
2018 Hottmann I, Mayer VMT, Tomek MB, Friedrich V, Calvert MB, Titz A, Schäffer C, Mayer C. -Acetylmuramic Acid (MurNAc) Auxotrophy of the Oral Pathogen: Characterization of a MurNAc Kinase and Analysis of Its Role in Cell Wall Metabolism. Frontiers in Microbiology. 9: 19. PMID 29434575 DOI: 10.3389/Fmicb.2018.00019  0.774
2018 Sommer R, Makshakova ON, Wohlschlager T, Hutin S, Marsh M, Titz A, Künzler M, Varrot A. Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense. Structure (London, England : 1993). 26: 391-402.e4. PMID 29398527 DOI: 10.1016/J.Str.2018.01.003  0.67
2017 Calvert MB, Mayer C, Titz A. An efficient synthesis of 1,6-anhydro--acetylmuramic acid from -acetylglucosamine. Beilstein Journal of Organic Chemistry. 13: 2631-2636. PMID 30018663 DOI: 10.3762/Bjoc.13.261  0.755
2017 Sommer R, Wagner S, Rox K, Varrot A, Hauck D, Wamhoff EC, Schreiber J, Ryckmans T, Brunner T, Rademacher C, Hartmann RW, Brönstrup M, Imberty A, Titz A. Glycomimetic, orally bioavailable LecB inhibitors block biofilm formation of Pseudomonas aeruginosa. Journal of the American Chemical Society. PMID 29272578 DOI: 10.1021/Jacs.7B11133  0.826
2017 Beshr G, Sikandar A, Jemiller EM, Klymiuk N, Hauck D, Wagner S, Wolf E, Koehnke J, Titz A. Photorhabdus luminescens lectin A (PllA) - a new probe for detecting α-galactoside-terminating glycoconjugates. The Journal of Biological Chemistry. PMID 28972138 DOI: 10.1074/Jbc.M117.812792  0.777
2017 Wagner S, Hauck D, Hoffmann M, Sommer R, Joachim I, Müller R, Imberty A, Varrot A, Titz A. Covalent lectin inhibition and application in bacterial biofilm imaging. Angewandte Chemie (International Ed. in English). PMID 28960731 DOI: 10.1002/Anie.201709368  0.826
2017 Hu Y, Beshr G, Garvey CJ, Tabor RF, Titz A, Wilkinson BL. Photoswitchable Janus glycodendrimer micelles as multivalent inhibitors of LecA and LecB from Pseudomonas aeruginosa. Colloids and Surfaces. B, Biointerfaces. 159: 605-612. PMID 28858663 DOI: 10.1016/J.Colsurfb.2017.08.016  0.759
2017 Torge A, Wagner S, Chaves PS, Oliveira EG, Guterres SS, Pohlmann AR, Titz A, Schneider M, Beck RCR. Ciprofloxacin-loaded lipid-core nanocapsules as mucus penetrating drug delivery system intended for the treatment of bacterial infections in cystic fibrosis. International Journal of Pharmaceutics. PMID 28499793 DOI: 10.1016/J.Ijpharm.2017.05.013  0.773
2016 Sommer R, Wagner S, Varrot A, Nycholat CM, Khaledi A, Häussler S, Paulson JC, Imberty A, Titz A. The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery. Chemical Science. 7: 4990-5001. PMID 30155149 DOI: 10.1039/C6Sc00696E  0.82
2016 Sommer R, Hauck D, Varrot A, Imberty A, Künzler M, Titz A. -Alkylated heavy atom carbohydrate probes for protein X-ray crystallography: Studies towards the synthesis of methyl 2--methyl-L-selenofucopyranoside. Beilstein Journal of Organic Chemistry. 12: 2828-2833. PMID 28144356 DOI: 10.3762/Bjoc.12.282  0.691
2016 Joachim I, Rikker S, Hauck D, Ponader D, Boden S, Sommer R, Hartmann L, Titz A. Development and optimization of a competitive binding assay for the galactophilic low affinity lectin LecA from Pseudomonas aeruginosa. Organic & Biomolecular Chemistry. PMID 27488655 DOI: 10.1039/C6Ob01313A  0.729
2016 Wagner S, Sommer R, Hinsberger S, Lu C, Hartmann RW, Empting M, Titz A. Novel Strategies for the treatment of Pseudomonas aeruginosa infections. Journal of Medicinal Chemistry. PMID 26804741 DOI: 10.1021/Acs.Jmedchem.5B01698  0.812
2016 Beshr G, Sommer R, Hauck D, Siebert DCB, Hofmann A, Imberty A, Titz A. Development of a competitive binding assay for the Burkholderia cenocepacia lectin BC2L-A and structure activity relationship of natural and synthetic inhibitors Medchemcomm. 7: 519-530. DOI: 10.1039/C5Md00557D  0.804
2015 Sommer R, Hauck D, Varrot A, Wagner S, Audfray A, Prestel A, Möller HM, Imberty A, Titz A. Cinnamide Derivatives of d-Mannose as Inhibitors of the Bacterial Virulence Factor LecB from Pseudomonas aeruginosa. Chemistryopen. 4: 756-67. PMID 27308201 DOI: 10.1002/Open.201500162  0.839
2015 Rodrigues JA, Acosta-Serrano A, Aebi M, Ferguson MA, Routier FH, Schiller I, Soares S, Spencer D, Titz A, Wilson IB, Izquierdo L. Parasite Glycobiology: A Bittersweet Symphony. Plos Pathogens. 11: e1005169. PMID 26562305 DOI: 10.1371/Journal.Ppat.1005169  0.687
2015 Hofmann A, Sommer R, Hauck D, Stifel J, Göttker-Schnetmann I, Titz A. Synthesis of mannoheptose derivatives and their evaluation as inhibitors of the lectin LecB from the opportunistic pathogen Pseudomonas aeruginosa. Carbohydrate Research. 412: 34-42. PMID 26004349 DOI: 10.1016/J.Carres.2015.04.010  0.711
2015 Yan S, Brecker L, Jin C, Titz A, Dragosits M, Karlsson NG, Jantsch V, Wilson IB, Paschinger K. Bisecting Galactose as a Feature of N-Glycans of Wild-type and Mutant Caenorhabditis elegans. Molecular & Cellular Proteomics : McP. 14: 2111-25. PMID 26002521 DOI: 10.1074/Mcp.M115.049817  0.599
2014 Sommer R, Exner TE, Titz A. A biophysical study with carbohydrate derivatives explains the molecular basis of monosaccharide selectivity of the Pseudomonas aeruginosa lectin LecB. Plos One. 9: e112822. PMID 25415418 DOI: 10.1371/Journal.Pone.0112822  0.738
2014 Wohlschlager T, Butschi A, Grassi P, Sutov G, Gauss R, Hauck D, Schmieder SS, Knobel M, Titz A, Dell A, Haslam SM, Hengartner MO, Aebi M, Künzler M. Methylated glycans as conserved targets of animal and fungal innate defense. Proceedings of the National Academy of Sciences of the United States of America. 111: E2787-96. PMID 24879441 DOI: 10.1073/Pnas.1401176111  0.63
2014 Mosca S, Keller J, Azzouz N, Wagner S, Titz A, Seeberger PH, Brezesinski G, Hartmann L. Amphiphilic cationic β(3R3)-peptides: membrane active peptidomimetics and their potential as antimicrobial agents. Biomacromolecules. 15: 1687-95. PMID 24694059 DOI: 10.1021/Bm500101W  0.742
2013 Sommer R, Joachim I, Wagner S, Titz A. New approaches to control infections: anti-biofilm strategies against gram-negative bacteria. Chimia. 67: 286-90. PMID 23967708 DOI: 10.2533/Chimia.2013.286  0.816
2013 Hauck D, Joachim I, Frommeyer B, Varrot A, Philipp B, Möller HM, Imberty A, Exner TE, Titz A. Discovery of two classes of potent glycomimetic inhibitors of Pseudomonas aeruginosa LecB with distinct binding modes. Acs Chemical Biology. 8: 1775-84. PMID 23719508 DOI: 10.1021/Cb400371R  0.7
2012 Titz A, Marra A, Cutting B, Smieško M, Papandreou G, Dondoni A, Ernst B. Conformational constraints: Nature does it best with sialyl Lewis x European Journal of Organic Chemistry. 5534-5539. DOI: 10.1002/Ejoc.201200744  0.611
2010 Butschi A, Titz A, Wälti MA, Olieric V, Paschinger K, Nöbauer K, Guo X, Seeberger PH, Wilson IB, Aebi M, Hengartner MO, Künzler M. Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2. Plos Pathogens. 6: e1000717. PMID 20062796 DOI: 10.1371/Journal.Ppat.1000717  0.713
2010 Titz A, Patton J, Smiesko M, Radic Z, Schwardt O, Magnani JL, Ernst B. Probing the carbohydrate recognition domain of E-selectin: the importance of the acid orientation in sLex mimetics. Bioorganic & Medicinal Chemistry. 18: 19-27. PMID 19948406 DOI: 10.1016/J.Bmc.2009.11.024  0.599
2009 Titz A, Butschi A, Henrissat B, Fan YY, Hennet T, Razzazi-Fazeli E, Hengartner MO, Wilson IB, Künzler M, Aebi M. Molecular basis for galactosylation of core fucose residues in invertebrates: identification of caenorhabditis elegans N-glycan core alpha1,6-fucoside beta1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family. The Journal of Biological Chemistry. 284: 36223-33. PMID 19858195 DOI: 10.1074/Jbc.M109.058354  0.689
2008 Titz A, Patton J, Alker AM, Porro M, Schwardt O, Hennig M, Francotte E, Magnani J, Ernst B. Is adamantane a suitable substituent to pre-organize the acid orientation in E-selectin antagonists? Bioorganic & Medicinal Chemistry. 16: 1046-56. PMID 17845854 DOI: 10.1016/J.Bmc.2007.07.025  0.598
2007 Titz A, Ernst B. Mimetics of Sialyl Lewis x : The Pre-Organization of the Carboxylic Acid is Essential for Binding to Selectins Chimia. 61: 194-197. DOI: 10.2533/Chimia.2007.194  0.616
2006 Ramić E, Eichel RA, Dinse KP, Titz A, Schmidt B. Complexation of copper(II)-Chelidamate: A multifrequency-pulsed electron paramagnetic resonance and electron nuclear double resonance analysis. The Journal of Physical Chemistry. B. 110: 20655-63. PMID 17034256 DOI: 10.1021/jp061940u  0.444
2006 Titz A, Radic Z, Schwardt O, Ernst B. A Safe and Convenient Method for the Preparation of Triflyl Azide, and Its Use in Diazo Transfer Reactions to Primary Amines. Cheminform. 37. DOI: 10.1016/J.Tetlet.2006.01.157  0.541
2004 Deffieux D, Fabre I, Titz A, Léger JM, Quideau S. Electrochemical synthesis of dimerizing and nondimerizing orthoquinone monoketals. The Journal of Organic Chemistry. 69: 8731-8. PMID 15575750 DOI: 10.1021/Jo048677I  0.596
2004 Schmidt B, Jiricek J, Titz A, Ye G, Parang K. Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain. Bioorganic & Medicinal Chemistry Letters. 14: 4203-6. PMID 15261270 DOI: 10.1016/J.Bmcl.2004.06.018  0.579
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