| Year |
Citation |
Score |
| 2023 |
Mills CM, Benton TZ, Piña I, Francis MJ, Reyes L, Dolloff NG, Peterson YK, Woster PM. Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma. Chemical Science. 14: 2168-2182. PMID 36845935 DOI: 10.1039/d2sc05749b |
0.803 |
|
| 2022 |
Mills CM, Turner J, Piña IC, Garrabrant KA, Geerts D, Bachmann AS, Peterson YK, Woster PM. Synthesis and evaluation of small molecule inhibitors of LSD1 for use against MYCN-expressing neuroblastoma. European Journal of Medicinal Chemistry. 244: 114818. PMID 36223680 DOI: 10.1016/j.ejmech.2022.114818 |
0.822 |
|
| 2022 |
Furbish AB, Alford AS, Burger P, Peterson YK, Murray-Stewart T, Casero RA, Woster PM. Identification and Characterization of Novel Small-Molecule SMOX Inhibitors. Medical Sciences (Basel, Switzerland). 10. PMID 36135832 DOI: 10.3390/medsci10030047 |
0.822 |
|
| 2022 |
Reader J, Opperman D, van der Watt M, Theron A, Leshabane M, da Rocha S, Turner J, Garrabrant K, Piña I, Mills C, Woster P, Birkholtz LM. New Transmission-Selective Antimalarial Agents through Hit-To-Lead Optimization of 2-([1,1'-biphenyl]-4-carboxamido)benzoic acid Derivatives. Chembiochem : a European Journal of Chemical Biology. PMID 36106425 DOI: 10.1002/cbic.202200427 |
0.801 |
|
| 2022 |
Beck TC, Springs K, Morningstar JE, Mills C, Stoddard A, Guo L, Moore K, Gensemer C, Biggs R, Petrucci T, Kwon J, Stayer K, Koren N, Dunne J, Fulmer D, ... ... Woster P, et al. Application of Pharmacokinetic Prediction Platforms in the Design of Optimized Anti-Cancer Drugs. Molecules (Basel, Switzerland). 27. PMID 35744803 DOI: 10.3390/molecules27123678 |
0.628 |
|
| 2022 |
Heslop KA, Burger P, Kappler C, Solanki AK, Gooz M, Peterson YK, Mills C, Benton T, Duncan SA, Woster PM, Maldonado EN. Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 150: 112928. PMID 35447542 DOI: 10.1016/j.biopha.2022.112928 |
0.775 |
|
| 2021 |
Benton TZ, Mills CM, Turner JM, Francis MJ, Solomon DJ, Burger PB, Peterson YK, Dolloff NG, Bachmann AS, Woster PM. Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation. Rsc Advances. 11: 33260-33270. PMID 35497564 DOI: 10.1039/d1ra06266b |
0.785 |
|
| 2021 |
Urban-Wójciuk Z, Graham A, Barker K, Kwok C, Sbirkov Y, Howell L, Campbell J, Woster PM, Poon E, Petrie K, Chesler L. The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme. Cancer Gene Therapy. PMID 34522028 DOI: 10.1038/s41417-021-00386-6 |
0.301 |
|
| 2020 |
Holshouser S, Cafiero R, Robinson M, Kirkpatrick J, Casero RA, Hyacinth HI, Woster PM. Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease. Acs Omega. 5: 14750-14758. PMID 32596612 DOI: 10.1021/acsomega.0c01585 |
0.804 |
|
| 2020 |
Sierra JC, Piazuelo MB, Luis PB, Barry DP, Allaman MM, Asim M, Sebrell TA, Finley JL, Rose KL, Hill S, Holshouser SL, Casero RA, Cleveland JL, Woster PM, Schey KL, et al. Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling. Oncogene. PMID 32350444 DOI: 10.1038/S41388-020-1304-6 |
0.758 |
|
| 2019 |
Holshouser S, Dunworth M, Murray-Stewart T, Peterson YK, Burger P, Kirkpatrick J, Chen HH, Casero RA, Woster PM. Dual inhibitors of LSD1 and spermine oxidase. Medchemcomm. 10: 778-790. PMID 31191868 DOI: 10.1039/C8Md00610E |
0.824 |
|
| 2019 |
El Bissati K, Redel H, Ting LM, Lykins JD, McPhillie MJ, Upadhya R, Woster PM, Yarlett N, Kim K, Weiss LM. Novel Synthetic Polyamines Have Potent Antimalarial Activities and by Decreasing Intracellular Spermidine and Spermine Concentrations. Frontiers in Cellular and Infection Microbiology. 9: 9. PMID 30838177 DOI: 10.3389/Fcimb.2019.00009 |
0.472 |
|
| 2018 |
Murray-Stewart T, Dunworth M, Lui Y, Giardiello FM, Woster PM, Casero RA. Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. Plos One. 13: e0202677. PMID 30138353 DOI: 10.1371/Journal.Pone.0202677 |
0.427 |
|
| 2018 |
Kirkpatrick JE, Kirkwood KL, Woster PM. Inhibition of the Histone Demethylase KDM4B Leads to Activation of KDM1A, Attenuates Bacterial-Induced Pro-Inflammatory Cytokine Release, and Reduces Osteoclastogenesis. Epigenetics. PMID 29927684 DOI: 10.1080/15592294.2018.1481703 |
0.645 |
|
| 2018 |
Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA, Woster PM. Corrigendum to "Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures" [Bioorg. Med. Chem. 23 (2015) 1601-1612]. Bioorganic & Medicinal Chemistry. PMID 29859749 DOI: 10.1016/J.Bmc.2018.05.032 |
0.766 |
|
| 2018 |
Kumarasinghe IR, Woster PM. Cyclic by peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis. European Journal of Medicinal Chemistry. 148: 210-220. PMID 29459279 DOI: 10.1016/J.Ejmech.2018.01.098 |
0.459 |
|
| 2016 |
Murray-Stewart TR, Woster PM, Casero RA. Targeting polyamine metabolism for cancer therapy and prevention. The Biochemical Journal. 473: 2937-53. PMID 27679855 DOI: 10.1042/Bcj20160383 |
0.306 |
|
| 2016 |
Wang B, Pachaiyappan B, Gruber JD, Schmidt MG, Zhang Y, Woster PM. Antibacterial Diamines Targeting Bacterial Membranes. Journal of Medicinal Chemistry. PMID 26964758 DOI: 10.1021/Acs.Jmedchem.5B01912 |
0.318 |
|
| 2016 |
Conway SJ, Woster PM, Greenlee WJ, Georg G, Wang S. Epigenetics: Novel Therapeutics Targeting Epigenetics. Journal of Medicinal Chemistry. PMID 26824165 DOI: 10.1021/Acs.Jmedchem.6B00098 |
0.363 |
|
| 2015 |
Li Y, Woster PM. Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group. Medchemcomm. 6: 613-618. PMID 26005563 DOI: 10.1039/C4Md00401A |
0.732 |
|
| 2015 |
Nowotarski SL, Pachaiyappan B, Holshouser SL, Kutz CJ, Li Y, Huang Y, Sharma SK, Casero RA, Woster PM. Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures. Bioorganic & Medicinal Chemistry. 23: 1601-12. PMID 25725609 DOI: 10.1016/J.Bmc.2015.01.049 |
0.805 |
|
| 2015 |
Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG. Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9. The Journal of Biological Chemistry. 290: 9812-22. PMID 25713082 DOI: 10.1074/Jbc.M114.616219 |
0.305 |
|
| 2015 |
Verlinden BK, de Beer M, Pachaiyappan B, Besaans E, Andayi WA, Reader J, Niemand J, van Biljon R, Guy K, Egan T, Woster PM, Birkholtz LM. Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites. Bioorganic & Medicinal Chemistry. 23: 5131-43. PMID 25684422 DOI: 10.1016/J.Bmc.2015.01.036 |
0.425 |
|
| 2015 |
Cafiero RM, Holshouser S, Kutz C, Kanter J, Woster P. Novel Epigenetic Modulators That Promote Fetal Hemoglobin Production for the Prevention of Sickle Cell Disease Related Complications Blood. 126: 973-973. DOI: 10.1182/Blood.V126.23.973.973 |
0.796 |
|
| 2015 |
Li Y, Woster PM. Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group Medchemcomm. 6: 613-618. DOI: 10.1039/c4md00401a |
0.636 |
|
| 2014 |
Kutz CJ, Holshouser SL, Marrow EA, Woster PM. 3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors. Medchemcomm. 5: 1863-1870. PMID 25580204 DOI: 10.1039/C4Md00283K |
0.825 |
|
| 2014 |
Kumarasinghe IR, Woster PM. Synthesis and evaluation of novel cyclic Peptide inhibitors of lysine-specific demethylase 1. Acs Medicinal Chemistry Letters. 5: 29-33. PMID 24883177 DOI: 10.1021/Ml4002997 |
0.463 |
|
| 2014 |
Pachaiyappan B, Woster PM. Design of small molecule epigenetic modulators Bioorganic and Medicinal Chemistry Letters. 24: 21-32. PMID 24300735 DOI: 10.1016/J.Bmcl.2013.11.001 |
0.386 |
|
| 2014 |
Hayes CS, DeFeo-Mattox K, Woster PM, Gilmour SK. Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites Amino Acids. 46: 543-552. PMID 23884694 DOI: 10.1007/S00726-013-1559-0 |
0.304 |
|
| 2014 |
Murray-Stewart T, Woster PM, Casero RA. The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines Amino Acids. 46: 585-594. PMID 23508577 DOI: 10.1007/S00726-013-1485-1 |
0.455 |
|
| 2014 |
Kutz CJ, Holshouser SL, Marrow EA, Woster PM. 3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors Medchemcomm. 5: 1863-1870. DOI: 10.1039/c4md00283k |
0.805 |
|
| 2013 |
Murray-Stewart T, Hanigan CL, Woster PM, Marton LJ, Casero RA. Histone deacetylase inhibition overcomes drug resistance through a miRNA-dependent mechanism Molecular Cancer Therapeutics. 12: 2088-2099. PMID 23943804 DOI: 10.1158/1535-7163.Mct-13-0418 |
0.445 |
|
| 2013 |
Nowotarski SL, Woster PM, Casero RA. Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert Reviews in Molecular Medicine. 15: e3. PMID 23432971 DOI: 10.1017/Erm.2013.3 |
0.336 |
|
| 2013 |
Jin L, Hanigan CL, Wu Y, Wang W, Park BH, Woster PM, Casero RA. Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1 (DNA methyltransferase 1)-independent manner Biochemical Journal. 449: 459-468. PMID 23072722 DOI: 10.1042/Bj20121360 |
0.38 |
|
| 2013 |
Woster PM. Synthetic small molecule epigenetic modulators as antitumor agents Medicinal Chemistry. DOI: 10.4172/2161-0444.S1.009 |
0.37 |
|
| 2012 |
Sharma SK, Hazeldine S, Crowley ML, Hanson A, Beattie R, Varghese S, Senanayake TM, Hirata A, Hirata F, Huang Y, Wu Y, Steinbergs N, Murray-Stewart T, Bytheway I, Casero RA, ... Woster PM, et al. Polyamine-based small molecule epigenetic modulators. Medchemcomm. 3: 14-21. PMID 23293738 DOI: 10.1039/C1Md00220A |
0.813 |
|
| 2012 |
Hazeldine S, Pachaiyappan B, Steinbergs N, Nowotarski S, Hanson AS, Casero RA, Woster PM. Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1 Journal of Medicinal Chemistry. 55: 7378-7391. PMID 22876979 DOI: 10.1021/Jm3002845 |
0.529 |
|
| 2012 |
Yedidi RS, Liu Z, Wang Y, Brunzelle JS, Kovari IA, Woster PM, Kovari LC, Gupta D. Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds Biochemical and Biophysical Research Communications. 421: 413-417. PMID 22469467 DOI: 10.1016/J.Bbrc.2012.03.096 |
0.522 |
|
| 2012 |
Schenk T, Chen WC, Göllner S, Howell L, Jin L, Hebestreit K, Klein HU, Popescu AC, Burnett A, Mills K, Casero RA, Marton L, Woster P, Minden MD, Dugas M, et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nature Medicine. 18: 605-11. PMID 22406747 DOI: 10.1038/Nm.2661 |
0.393 |
|
| 2012 |
Fraser AV, Goodwin AC, Hacker-Prietz A, Sugar E, Woster PM, Casero RA. Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells. Amino Acids. 42: 529-38. PMID 21814790 DOI: 10.1007/S00726-011-1030-Z |
0.392 |
|
| 2012 |
Zhu Q, Huang Y, Marton LJ, Woster PM, Davidson NE, Casero RA. Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells. Amino Acids. 42: 887-98. PMID 21805138 DOI: 10.1007/S00726-011-1004-1 |
0.371 |
|
| 2012 |
Sharma SK, Hazeldine S, Crowley ML, Hanson A, Beattie R, Varghese S, Senanayake TMD, Hirata A, Hirata F, Huang Y, Wu Y, Steinbergs N, Murray-Stewart T, Bytheway I, Casero RA, ... Woster PM, et al. Polyamine-based small molecule epigenetic modulators Medchemcomm. 3: 14-21. DOI: 10.1039/c1md00220a |
0.766 |
|
| 2011 |
Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ. Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. The Journal of Biological Chemistry. 286: 43301-12. PMID 22025614 DOI: 10.1074/Jbc.M111.307835 |
0.319 |
|
| 2011 |
Verlinden BK, Niemand J, Snyman J, Sharma SK, Beattie RJ, Woster PM, Birkholtz LM. Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities Journal of Medicinal Chemistry. 54: 6624-6633. PMID 21882831 DOI: 10.1021/jm200463z |
0.323 |
|
| 2011 |
Goodwin AC, Destefano Shields CE, Wu S, Huso DL, Wu X, Murray-Stewart TR, Hacker-Prietz A, Rabizadeh S, Woster PM, Sears CL, Casero RA. Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 15354-9. PMID 21876161 DOI: 10.1073/Pnas.1010203108 |
0.321 |
|
| 2011 |
Woster PM. Use of polyamine derivatives as selective histone deacetylase inhibitors. Methods in Molecular Biology (Clifton, N.J.). 720: 475-491. PMID 21318894 DOI: 10.1007/978-1-61779-034-8_31 |
0.465 |
|
| 2011 |
Schenk T, Göllner S, Chen WC, Howell L, Jin L, Hebestreit K, Klein H, Burnett AK, Mills KI, Marton L, Casero R, Woster P, Dugas M, Wang JC, Dick JE, et al. Histone H3 Methylation Mediates All-Trans-Retinoic Acid Responsiveness in Acute Myeloid Leukemia Blood. 118: 224-224. DOI: 10.1182/Blood.V118.21.224.224 |
0.415 |
|
| 2010 |
Cervelli M, Bellavia G, Fratini E, Amendola R, Polticelli F, Barba M, Federico R, Signore F, Gucciardo G, Grillo R, Woster PM, Casero RA, Mariottini P. Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm Bmc Cancer. 10. PMID 20946629 DOI: 10.1186/1471-2407-10-555 |
0.33 |
|
| 2010 |
Sharma SK, Wu Y, Steinbergs N, Crowley ML, Hanson AS, Casero RA, Woster PM. (Bis)urea and (Bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators Journal of Medicinal Chemistry. 53: 5197-5212. PMID 20568780 DOI: 10.1021/Jm100217A |
0.675 |
|
| 2010 |
Gupta D, Yedidi RS, Varghese S, Kovari LC, Woster PM. Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents Journal of Medicinal Chemistry. 53: 4234-4247. PMID 20438064 DOI: 10.1021/Jm100233B |
0.813 |
|
| 2010 |
Lee SB, Park JH, Woster PM, Casero RA, Park MH. Suppression of exogenous gene expression by spermidine/spermine N 1-acetyltransferase 1 (SSAT1) cotransfection Journal of Biological Chemistry. 285: 15548-15556. PMID 20212040 DOI: 10.1074/Jbc.M109.092007 |
0.342 |
|
| 2010 |
Pledgie-Tracy A, Billam M, Hacker A, Sobolewski MD, Woster PM, Zhang Z, Casero RA, Davidson NE. The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines. Cancer Chemotherapy and Pharmacology. 65: 1067-81. PMID 19727732 DOI: 10.1007/S00280-009-1112-8 |
0.343 |
|
| 2010 |
Wu Y, Marton LJ, Woster PM, Casero RA. Abstract 4884: Polyamine analogues in combination with DFMO inhibits lysine-specific demethylase 1 and induces re-expression of aberrantly silenced genes Cancer Research. 70: 4884-4884. DOI: 10.1158/1538-7445.Am10-4884 |
0.435 |
|
| 2010 |
Zhu Q, Huang Y, Marton LJ, Woster PM, Davidson NE, Casero RA. Abstract 4877: Polyamine analogues modulate gene expression by inhibiting KDM1/LSD1 and altering chromatin structure in human breast cancer cells Cancer Research. 70: 4877-4877. DOI: 10.1158/1538-7445.Am10-4877 |
0.382 |
|
| 2010 |
Woster PM. Epigenetic Targets and Cancer Drug Discovery Annual Reports in Medicinal Chemistry. 45: 245-260. DOI: 10.1016/S0065-7743(10)45015-0 |
0.464 |
|
| 2009 |
Susick L, Senanayake T, Veluthakal R, Woster PM, Kowluru A. A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells Journal of Cellular and Molecular Medicine. 13: 1877-1885. PMID 20141611 DOI: 10.1111/J.1582-4934.2009.00672.X |
0.773 |
|
| 2009 |
Huang Y, Marton LJ, Woster PM, Casero RA. Polyamine analogues targeting epigenetic gene regulation Essays in Biochemistry. 46: 95-110. PMID 20095972 DOI: 10.1042/Bse0460007 |
0.503 |
|
| 2009 |
Senanayake MDT, Amunugama H, Boncher TD, Casero RA, Woster PM. Design of polyamine-based therapeutic agents: New targets and new directions Essays in Biochemistry. 46: 77-94. PMID 20095971 DOI: 10.1042/Bse0460006 |
0.8 |
|
| 2009 |
Huang Y, Stewart TM, Wu Y, Baylin SB, Marton LJ, Perkins B, Jones RJ, Woster PM, Casero RA. Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 7217-28. PMID 19934284 DOI: 10.1158/1078-0432.Ccr-09-1293 |
0.415 |
|
| 2009 |
Casero RA, Woster PM. Recent advances in the development of polyamine analogues as antitumor agents Journal of Medicinal Chemistry. 52: 4551-4573. PMID 19534534 DOI: 10.1021/Jm900187V |
0.447 |
|
| 2009 |
Uimari A, Keinänen TA, Karppinen A, Woster P, Uimari P, Jänne J, Alhonen L. Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts Biochemical Journal. 422: 101-109. PMID 19473115 DOI: 10.1042/Bj20090411 |
0.353 |
|
| 2008 |
Wei G, DeFeo K, Hayes CS, Woster PM, Mandik-Nayak L, Gilmour SK. Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes Cancer Research. 68: 2214-2222. PMID 18381427 DOI: 10.1158/0008-5472.Can-07-5030 |
0.35 |
|
| 2008 |
Varghese S, Senanayake T, Murray-Stewart T, Doering K, Fraser A, Casero RA, Woster PM. Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors Journal of Medicinal Chemistry. 51: 2447-2456. PMID 18348516 DOI: 10.1021/Jm701384X |
0.815 |
|
| 2007 |
Huang Y, Greene E, Murray Stewart T, Goodwin AC, Baylin SB, Woster PM, Casero RA. Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proceedings of the National Academy of Sciences of the United States of America. 104: 8023-8. PMID 17463086 DOI: 10.1073/Pnas.0700720104 |
0.41 |
|
| 2007 |
Boncher T, Bi X, Varghese S, Casero RA, Woster PM. Polyamine-based analogues as biochemical probes and potential therapeutics Biochemical Society Transactions. 35: 356-363. PMID 17371278 DOI: 10.1042/Bst0350356 |
0.833 |
|
| 2006 |
Bi X, Lopez C, Bacchi CJ, Rattendi D, Woster PM. Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity Bioorganic and Medicinal Chemistry Letters. 16: 3229-3232. PMID 16616495 DOI: 10.1016/J.Bmcl.2006.03.048 |
0.406 |
|
| 2006 |
Woster PM. A Review of: “Evaluation of Enzyme Inhibitors in Drug Discovery” Drug Development and Industrial Pharmacy. 32: 399-400. DOI: 10.1080/03639040500519466 |
0.346 |
|
| 2005 |
Casero RA, Frydman B, Stewart TM, Woster PM. Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues. Proceedings of the Western Pharmacology Society. 48: 24-30. PMID 16416654 |
0.312 |
|
| 2005 |
Pledgie A, Huang Y, Hacker A, Zhang Z, Woster PM, Davidson NE, Casero RA. Spermine oxidase SMO(PAOh1), not N1-acetylpolyamine oxidase PAO, is the primary source of Cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines Journal of Biological Chemistry. 280: 39843-39851. PMID 16207710 DOI: 10.1074/Jbc.M508177200 |
0.384 |
|
| 2005 |
Varghese S, Gupta D, Baran T, Jiemjit A, Gore SD, Casero RA, Woster PM. Alkyl-substituted polyaminohydroxamic acids: A novel class of targeted histone deacetylase inhibitors Journal of Medicinal Chemistry. 48: 6350-6365. PMID 16190761 DOI: 10.1021/Jm0505009 |
0.832 |
|
| 2005 |
Huang Y, Pledgie A, Rubin E, Marton LJ, Woster PM, Sukumar S, Casero RA, Davidson NE. Role of p53/p21Waf1/Cip1 in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells Cancer Biology and Therapy. 4: 1006-1013. PMID 16131835 DOI: 10.4161/Cbt.4.9.1970 |
0.396 |
|
| 2005 |
Vyas PM, Roychowdhury S, Woster PM, Svensson CK. Reactive oxygen species generation and its role in the differential cytotoxicity of the arylhydroxylamine metabolites of sulfamethoxazole and dapsone in normal human epidermal keratinocytes Biochemical Pharmacology. 70: 275-286. PMID 15894292 DOI: 10.1016/J.Bcp.2005.04.023 |
0.302 |
|
| 2005 |
Wang Y, Hacker A, Murray-Stewart T, Frydman B, Valasinas A, Fraser AV, Woster PM, Casero RA. Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): Potential role in determining drug sensitivity Cancer Chemotherapy and Pharmacology. 56: 83-90. PMID 15791459 DOI: 10.1007/S00280-004-0936-5 |
0.385 |
|
| 2005 |
Wang Y, Hacker A, Murray-Stewart T, Fleischer JG, Woster PM, Casero RA. Induction of human spermine oxidase SMO(PAOh1) is regulated at the levels of new mRNA synthesis, mRNA stabilization and newly synthesized protein. The Biochemical Journal. 386: 543-7. PMID 15496143 DOI: 10.1042/Bj20041084 |
0.362 |
|
| 2004 |
Bacchi CJ, Rattendi D, Faciane E, Yarlett N, Weiss LM, Frydman B, Woster P, Wei B, Marton LJ, Wittner M. Polyamine metabolism in a member of the phylum microspora (Encephalitozoon cuniculi): Effects of polyamine analogues Microbiology. 150: 1215-1224. PMID 15133083 DOI: 10.1099/Mic.0.26889-0 |
0.41 |
|
| 2003 |
Devereux W, Wang Y, Stewart TM, Hacker A, Smith R, Frydman B, Valasinas AL, Reddy VK, Marton LJ, Ward TD, Woster PM, Casero RA. Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. Cancer Chemotherapy and Pharmacology. 52: 383-90. PMID 12827295 DOI: 10.1007/S00280-003-0662-4 |
0.788 |
|
| 2003 |
Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA. Properties of purified recombinant human polyamine oxidase, PAOh1/SMO Biochemical and Biophysical Research Communications. 304: 605-611. PMID 12727196 DOI: 10.1016/S0006-291X(03)00636-3 |
0.356 |
|
| 2003 |
Casero RA, Wang Y, Stewart TM, Devereux W, Hacker A, Wang Y, Smith R, Woster PM. The role of polyamine catabolism in anti-tumour drug response. Biochemical Society Transactions. 31: 361-5. PMID 12653639 DOI: 10.1042/Bst0310361 |
0.416 |
|
| 2002 |
Fraser AV, Woster PM, Wallace HM. Induction of apoptosis in human leukaemic cells by IPENSpm, a novel polyamine analogue and anti-metabolite. The Biochemical Journal. 367: 307-12. PMID 12086584 DOI: 10.1042/Bj20020156 |
0.44 |
|
| 2001 |
Wang Y, Devereux W, Woster PM, Stewart TM, Hacker A, Casero RA. Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. Cancer Research. 61: 5370-3. PMID 11454677 |
0.327 |
|
| 2001 |
Zou Y, Wu Z, Sirisoma N, Woster PM, Casero RA, Weiss LM, Rattendi D, Lane S, Bacchi CJ. Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity Bioorganic and Medicinal Chemistry Letters. 11: 1613-1617. PMID 11412992 DOI: 10.1016/S0960-894X(01)00315-8 |
0.415 |
|
| 2001 |
Casero JA, Woster PM. Terminally alkylated polyamine analogues as chemotherapeutic agents Journal of Medicinal Chemistry. 44: 1-26. PMID 11141084 DOI: 10.1021/Jm000084M |
0.396 |
|
| 2001 |
Woster PM. Chapter 10. New therapies for parasitic infection Annual Reports in Medicinal Chemistry. 36: 99-108. DOI: 10.1016/S0065-7743(01)36050-5 |
0.349 |
|
| 2000 |
Reilly TP, Lash LH, Doll MA, Hein DW, Woster PM, Svensson CK. A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions. The Journal of Investigative Dermatology. 114: 1164-73. PMID 10844561 DOI: 10.1046/J.1523-1747.2000.00985.X |
0.321 |
|
| 2000 |
Iyer R, Wu Z, Woster PM, Delcour AH. Molecular basis for the polyamine-ompF porin interactions: inhibitor and mutant studies. Journal of Molecular Biology. 297: 933-45. PMID 10736228 DOI: 10.1006/Jmbi.2000.3599 |
0.371 |
|
| 2000 |
Nairn LM, Lindsay GS, Woster PM, Wallace HM. Cytotoxicity of novel unsymmetrically substituted inhibitors of polyamine biosynthesis in human cancer cells. Journal of Cellular Physiology. 182: 209-13. PMID 10623884 DOI: 10.1002/(Sici)1097-4652(200002)182:2<209::Aid-Jcp9>3.0.Co;2-8 |
0.412 |
|
| 1999 |
Davidson NE, Hahm HA, McCloskey DE, Woster PM, Casero RA. Clinical aspects of cell death in breast cancer: The polyamine pathway as a new target for treatment Endocrine-Related Cancer. 6: 69-73. PMID 10732790 DOI: 10.1677/Erc.0.0060069 |
0.336 |
|
| 1999 |
Webb HK, Wu Z, Sirisoma N, Ha HC, Casero RA, Woster PM. 1-(N-alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: Simple synthetic polyamine analogues that differentially alter tubulin polymerization Journal of Medicinal Chemistry. 42: 1415-1421. PMID 10212127 DOI: 10.1021/Jm980603+ |
0.404 |
|
| 1998 |
Reilly TP, Bellevue FH, Woster PM, Svensson CK. Comparison of the in vitro cytotoxicity of hydroxylamine metabolites of sulfamethoxazole and dapsone Biochemical Pharmacology. 55: 803-810. PMID 9586952 DOI: 10.1016/S0006-2952(97)00547-9 |
0.315 |
|
| 1998 |
Woster PM, Aoyama T, Satoh T, Yonemato M, Shibata J, Nonoshita K, Arai S, Kawakami K, Iwasawa Y, Sano H, Tanaka K, Monden Y, Kodera T, Arakawa H, Suzuki-Takahashi I, et al. A new class of highly potent farnesyl diphosphate-competitive inhibitors of farnesyl transferase Chemtracts. 11: 840-844. |
0.319 |
|
| 1997 |
Ha HC, Woster PM, Yager JD, Casero RA. The role of polyamine catabolism in polyamine analogue-induced programmed cell death Proceedings of the National Academy of Sciences of the United States of America. 94: 11557-11562. PMID 9326648 DOI: 10.1073/Pnas.94.21.11557 |
0.408 |
|
| 1997 |
Bellevue FH, Woster PM, Edwards DJ, He K, Hollenberg PF. Synthesis and biological evaluation of 6',7'-dihydroxybergamottin (6,7-DHB, a naturally occurring inhibitor of cytochrome P450 3A4 Bioorganic and Medicinal Chemistry Letters. 7: 2593-2598. DOI: 10.1016/S0960-894X(97)10043-9 |
0.355 |
|
| 1996 |
Wu R, Saab NH, Huang H, Wiest L, Pegg AE, Casero RA, Woster PM. Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase Bioorganic and Medicinal Chemistry. 4: 825-836. PMID 8818232 DOI: 10.1016/0968-0896(96)00072-7 |
0.829 |
|
| 1996 |
Bellevue FH, Boahbedason M, Wu R, Woster PM, Casero RA, Rattendi D, Lane S, Bacchi CJ. Structural comparison of alkylpolyamine analogues with potent in vitro antitumor or antiparasitic activity Bioorganic and Medicinal Chemistry Letters. 6: 2765-2770. DOI: 10.1016/S0960-894X(96)00510-0 |
0.718 |
|
| 1995 |
Guo J, Wu YQ, Rattendi D, Bacchi CJ, Woster PM. S-(5′-deoxy-5′-adenosyl)-1-aminoxy-4-(methylsulfonio)-2- cyclopentene (AdoMao): An irreversible inhibitor of S-adenosylmethionine decarboxylase with potent in vitro antitrypanosomal activity Journal of Medicinal Chemistry. 38: 1770-1777. PMID 7752200 DOI: 10.1021/Jm00010A021 |
0.478 |
|
| 1995 |
Wu YQ, Woster PM. Irreversible inhibition of human S-adenosylmethionine decarboxylase by the pure diastereomeric forms of S-(5′-deoxy-5′-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene (AdoMac) Biochemical Pharmacology. 49: 1125-1133. PMID 7748194 DOI: 10.1016/0006-2952(95)98510-G |
0.514 |
|
| 1995 |
Casero RA, Mank AR, Saab NH, Wu R, Dyer WJ, Woster PM. Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1. Cancer Chemotherapy and Pharmacology. 36: 69-74. PMID 7720179 DOI: 10.1007/Bf00685735 |
0.796 |
|
| 1995 |
Felschow DM, MacDiarmid J, Bardos T, Wu R, Woster PM, Porter CW. Photoaffinity labeling of a cell surface polyamine binding protein Journal of Biological Chemistry. 270: 28705-28711. PMID 7499391 DOI: 10.1074/Jbc.270.48.28705 |
0.661 |
|
| 1994 |
Vage C, Saab N, Woster PM, Svensson CK. Dapsone-induced hematologic toxicity: comparison of the methemoglobin-forming ability of hydroxylamine metabolites of dapsone in rat and human blood. Toxicology and Applied Pharmacology. 129: 309-16. PMID 7992320 DOI: 10.1006/Taap.1994.1255 |
0.664 |
|
| 1993 |
Saab NH, West EE, Bieszk NC, Preuss CV, Mank AR, Casero RA, Woster PM. Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents. Journal of Medicinal Chemistry. 36: 2998-3004. PMID 8411017 DOI: 10.1021/Jm00072A020 |
0.756 |
|
| 1993 |
Wu YQ, Woster PM. Preparation of the pure diastereomeric forms of S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene and their evaluation as irreversible inhibitors of S-adenosylmethionine decarboxylase from Escherichia coli. Bioorganic & Medicinal Chemistry. 1: 349-60. PMID 8081865 DOI: 10.1016/S0968-0896(00)82141-0 |
0.513 |
|
| 1993 |
Guo JQ, Wu YQ, Farmer WL, Douglas KA, Woster PM, Garofalo J, Basshi CJ. Restricted rotation analogs of S-adenosylmethionine: synthesis, evaluation as inhibitors of S-adenosylmethionine decarboxylase, and potential use as selective antitrypanosomal agents Bioorganic and Medicinal Chemistry Letters. 3: 147-152. DOI: 10.1016/S0960-894X(01)80865-9 |
0.606 |
|
| 1993 |
Wu YQ, Lawrence T, Guo JQ, Woster PM. α-cyano-substituted analogoues of decarboxylated S-adenosylmethionine as enzyme activated, irreversible inhibitors of S-adenosylmethionine decarboxylase Bioorganic and Medicinal Chemistry Letters. 3: 2811-2816. DOI: 10.1016/S0960-894X(01)80770-8 |
0.55 |
|
| 1992 |
Wu Y, Woster PM. S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2-cyclopentene: A potent, enzyme-activated irreversible inhibitor of S-adenosylmethionine decarboxylase. Journal of Medicinal Chemistry. 35: 3196-201. PMID 1507205 DOI: 10.1021/Jm00095A015 |
0.422 |
|
| 1991 |
Douglas KA, Zormeier MM, Marcolina LM, Woster PM. Restricted rotation analogs of decarboxylated S-adenosylmethionine as inhibitors of polyamine biosynthesis Bioorganic and Medicinal Chemistry Letters. 1: 267-270. DOI: 10.1016/S0960-894X(01)81040-4 |
0.409 |
|
| 1989 |
Woster PM, Black AY, Duff KJ, Coward JK, Pegg AE. Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase. Journal of Medicinal Chemistry. 32: 1300-7. PMID 2724300 DOI: 10.1021/Jm00126A026 |
0.638 |
|
| 1989 |
Pegg AE, Wechter R, Poulin R, Woster PM, Coward JK. Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry. 28: 8446-53. PMID 2605194 DOI: 10.1021/Bi00447A026 |
0.657 |
|
| 1986 |
Woster PM, Murray WJ. Synthesis and biological evaluation of cyclic analogues of 1-carnitine as potential agents in the treatment of myocardial ischemia. Journal of Medicinal Chemistry. 29: 865-8. PMID 3084787 DOI: 10.1021/Jm00155A045 |
0.585 |
|
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