Joseph A. Chemler, Ph.D.
Affiliations: | 2009 | Chemical and Biological Engineering | State University of New York, Buffalo, Buffalo, NY, United States |
Area:
Chemical Engineering, Biochemistry, Microbiology BiologyGoogle:
"Joseph Chemler"Parents
Sign in to add mentor| Mattheos A. G. Koffas | grad student | 2009 | SUNY Buffalo | |
| (Metabolic engineering of Escherichia coli and Saccharomyces cerevisiae to mutasynthesize natural phenylpropanoids and novel analogs.) | ||||
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Publications
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| Sherman DH, Koch AA, Schmidt J, et al. (2020) Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases. Angewandte Chemie (International Ed. in English) |
| Ratnayake AS, Chang LP, Tumey LN, et al. (2018) Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates. Bioconjugate Chemistry |
| Lowell AN, DeMars MD, Slocum ST, et al. (2017) Chemoenzymatic total synthesis and structural diversification of tylactone-based macrolide antibiotics through late-stage polyketide assembly, tailoring, and C-H functionalization. Journal of the American Chemical Society |
| Koryakina I, Kasey C, McArthur JB, et al. (2017) Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering. Acs Chemical Biology. 12: 114-123 |
| Chemler JA, Tripathi A, Hansen DA, et al. (2015) Evolution of Efficient Modular Polyketide Synthases by Homeologous Recombination. Journal of the American Chemical Society |
| Whicher JR, Dutta S, Hansen DA, et al. (2014) Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature. 510: 560-4 |
| Dutta S, Whicher JR, Hansen DA, et al. (2014) Structure of a modular polyketide synthase. Nature. 510: 512-7 |
| Chemler JA, Buchholz TJ, Geders TW, et al. (2012) Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor. Journal of the American Chemical Society. 134: 7359-66 |
| Bonnett SA, Rath CM, Shareef AR, et al. (2011) Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS. Chemistry & Biology. 18: 1075-81 |
| Chemler JA, Lim CG, Daiss JL, et al. (2010) A versatile microbial system for biosynthesis of novel polyphenols with altered estrogen receptor binding activity. Chemistry & Biology. 17: 392-401 |