Brian G. Lefebvre, Ph.D.

Affiliations: 
2002 University of Delaware, Newark, DE, United States 
Area:
Chemical Engineering, Biochemistry, General Biophysics
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"Brian Lefebvre"

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Anne Skaja Robinson grad student 2002 University of Delaware
 (High pressure dissociates tailspike aggregates and promotes native structure formation.)
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Publications

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Gage MJ, Lefebvre BG, Robinson AS. (2006) Determinants of protein folding and aggregation in P22 tailspike protein Misbehaving Proteins: Protein (Mis)Folding, Aggregation, and Stability. 247-264
Peterson RW, Lefebvre BG, Wand AJ. (2005) High-resolution NMR studies of encapsulated proteins in liquid ethane. Journal of the American Chemical Society. 127: 10176-7
Lefebvre BG, Liu W, Peterson RW, et al. (2005) NMR spectroscopy of proteins encapsulated in a positively charged surfactant. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 175: 158-62
Lefebvre BG, Comolli NK, Gage MJ, et al. (2004) Pressure dissociation studies provide insight into oligomerization competence of temperature-sensitive folding mutants of P22 tailspike. Protein Science : a Publication of the Protein Society. 13: 1538-46
Lefebvre BG, Gage MJ, Robinson AS. (2004) Maximizing recovery of native protein from aggregates by optimizing pressure treatment. Biotechnology Progress. 20: 623-9
Lefebvre BG, Robinson AS. (2003) Pressure treatment of tailspike aggregates rapidly produces on-pathway folding intermediates. Biotechnology and Bioengineering. 82: 595-604
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