Nicholas Boylan, Ph.D.

Affiliations: 
2012 Johns Hopkins University, Baltimore, MD 
Area:
Chemical Engineering
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"Nicholas Boylan"

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Justin Hanes grad student 2012 Johns Hopkins
 (New nanoparticle-based systems for pulmonary drug and gene delivery.)
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Publications

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Schneider CS, Xu Q, Boylan NJ, et al. (2017) Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation. Science Advances. 3: e1601556
Young HS, Shin E, Wang H, et al. (2016) A novel in situ hydrophobic ion paring (HIP) formulation strategy for clinical product selection of a nanoparticle drug delivery system. Journal of Controlled Release : Official Journal of the Controlled Release Society
Xu Q, Ensign LM, Boylan NJ, et al. (2015) Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo. Acs Nano. 9: 9217-27
Pan Q, Xu Q, Boylan NJ, et al. (2015) Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats. Journal of Controlled Release : Official Journal of the Controlled Release Society. 201: 32-40
Kim AJ, Woodworth GF, Boylan NJ, et al. (2014) Highly compacted pH-responsive DNA nanoparticles mediate transgene silencing in experimental glioma. Journal of Materials Chemistry. B, Materials For Biology and Medicine. 2: 8165-8173
da Silva AL, Martini SV, Abreu SC, et al. (2014) DNA nanoparticle-mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma. Journal of Controlled Release : Official Journal of the Controlled Release Society. 180: 125-33
Suk JS, Kim AJ, Trehan K, et al. (2014) Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier. Journal of Controlled Release : Official Journal of the Controlled Release Society. 178: 8-17
Xu Q, Boylan NJ, Cai S, et al. (2013) Scalable method to produce biodegradable nanoparticles that rapidly penetrate human mucus. Journal of Controlled Release : Official Journal of the Controlled Release Society. 170: 279-86
Kim AJ, Boylan NJ, Suk JS, et al. (2013) Use of single-site-functionalized PEG dendrons to prepare gene vectors that penetrate human mucus barriers. Angewandte Chemie (International Ed. in English). 52: 3985-8
Xu Q, Boylan NJ, Suk JS, et al. (2013) Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo. Journal of Controlled Release : Official Journal of the Controlled Release Society. 167: 76-84
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