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Nigel D. F. Grindley

Affiliations:

Molecular Biophysics and Biochemistry

Yale University, New Haven, CT

Area:

DNA Replication and Repair

Website:

http://medicine.yale.edu/mbb/faculty/research/nigel_grindley.profile

Google:

"Nigel D. F. Grindley"

Bio:

http://academy.asm.org/index.php/fellows-info/fellows-elected-in-2011/620-nigel-df-grindley

Mean distance: 8.66

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Parents

Ephraim S. Anderson	grad student	1974	University of London
William S. Kelley	post-doc	1973-1975	Carnegie Mellon
Joan A. Steitz	post-doc	1975-1978	Yale

Children

Earl May	grad student		Yale
Robert E. Hughes	grad student	1987-1992	Yale
Andres E. Leschziner	grad student	2000	Yale
Angela M. DeLucia	grad student	2007	Yale
Graham F. Hatfull	post-doc	1984-1988	Yale

Collaborators

BETA: Related publications

Publications

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Keenholtz RA, Grindley ND, Hatfull GF, et al. (2016) Crossover-site sequence and DNA torsional stress control strand interchanges by the Bxb1 site-specific serine recombinase. Nucleic Acids Research
Bermek O, Grindley ND, Joyce CM. (2013) Prechemistry nucleotide selection checkpoints in the reaction pathway of DNA polymerase I and roles of glu710 and tyr766. Biochemistry. 52: 6258-74
Hohlbein J, Aigrain L, Craggs TD, et al. (2013) Conformational landscapes of DNA polymerase I and mutator derivatives establish fidelity checkpoints for nucleotide insertion. Nature Communications. 4: 2131
Bai H, Kath JE, Zörgiebel FM, et al. (2012) Remote control of DNA-acting enzymes by varying the Brownian dynamics of a distant DNA end. Proceedings of the National Academy of Sciences of the United States of America. 109: 16546-51
Bai H, Kath J, Zorgebiel F, et al. (2012) Remote Control of DNA-Acting Enzymes by Molecular Boundary Conditions Biophysical Journal. 102: 70a
Bai H, Sun M, Ghosh P, et al. (2011) Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase. Proceedings of the National Academy of Sciences of the United States of America. 108: 7419-24
Bermek O, Grindley ND, Joyce CM. (2011) Distinct roles of the active-site Mg2+ ligands, Asp882 and Asp705, of DNA polymerase I (Klenow fragment) during the prechemistry conformational transitions. The Journal of Biological Chemistry. 286: 3755-66
Hohlbein J, Joyce CM, Shoolizadeh P, et al. (2011) Novel Conformational States in Mutator DNA Polymerases Observed Using Single-Molecule FRET Biophysical Journal. 100: 240a-241a
Santoso Y, Joyce CM, Potapova O, et al. (2010) Conformational transitions in DNA polymerase I revealed by single-molecule FRET. Proceedings of the National Academy of Sciences of the United States of America. 107: 715-20
Torella JP, Santoso Y, Holden SJ, et al. (2010) Separating Static and Dynamic Heterogeneity in Single-Molecule FRET Experiments with Burst Variance Analysis (BVA) Biophysical Journal. 98: 591a

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