Rakan El-Mayta

Affiliations: 
2018- Bioengineering University of Pennsylvania, Philadelphia, PA, United States 
Area:
drug delivery, mRNA, vaccines, lipid nanoparticles
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"Rakan El-Mayta"

Parents

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Erin B. Lavik research assistant 2016-2018 UMBC (Neurotree)
Michael J. Mitchell research assistant 2018-2023 Penn
Drew Weissman grad student 2023- University of Pennsylvania Perelman School of Medicine (Epi Tree)
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Publications

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Han X, Alameh MG, Xu Y, et al. (2024) Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution. Nature Biomedical Engineering. 8: 1412-1424
Xue L, Zhao G, Gong N, et al. (2024) Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery. Nature Nanotechnology
Gong N, Zhong W, Alameh MG, et al. (2024) Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery. Nature Materials
Han X, Alameh MG, Gong N, et al. (2024) Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo. Nature Chemistry
Gong N, Alameh MG, El-Mayta R, et al. (2024) Enhancing in situ cancer vaccines using delivery technologies. Nature Reviews. Drug Discovery
Hamilton AG, Swingle KL, Thatte AS, et al. (2024) High-Throughput Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route. Acs Nano
Gong N, Han X, Xue L, et al. (2024) Author Correction: Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Nature Biomedical Engineering
Xue L, Hamilton AG, Zhao G, et al. (2024) High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nature Communications. 15: 1884
Yang F, Akhtar MN, Zhang D, et al. (2024) An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Science Advances. 10: eadj4678
Han X, Xu J, Xu Y, et al. (2024) In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors. Nature Communications. 15: 1762
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