Mohamad-Gabriel Alameh, Ph.D

Affiliations: 
2023- Children’s Hospital of Philadelphia, Philadelphia, PA, United States 
 2023- Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine 
Area:
lipid nanoparticles, mRNA, vaccines, biomaterials
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"Mohamad-Gabriel Alameh"
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Publications

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Han X, Alameh MG, Xu Y, et al. (2024) Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution. Nature Biomedical Engineering. 8: 1412-1424
Leonard RA, Burke KN, Spreng RL, et al. (2024) Improved influenza vaccine responses after expression of multiple viral glycoproteins from a single mRNA. Nature Communications. 15: 8712
Alameh MG, Semon A, Bayard NU, et al. (2024) A multivalent mRNA-LNP vaccine protects against infection. Science (New York, N.Y.). 386: 69-75
Xue L, Zhao G, Gong N, et al. (2024) Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery. Nature Nanotechnology
Hajnik RL, Plante JA, Reddy Bonam S, et al. (2024) Broad protection and respiratory immunity of dual mRNA vaccination against SARS-CoV-2 variants. Npj Vaccines. 9: 160
Gong N, Zhong W, Alameh MG, et al. (2024) Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery. Nature Materials
Mu Z, Whitley J, Martik D, et al. (2024) Comparison of the immunogenicity of mRNA-encoded and protein HIV-1 Env-ferritin nanoparticle designs. Journal of Virology. e0013724
Guenaga J, Alirezaei M, Feng Y, et al. (2024) mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies. Frontiers in Immunology. 15: 1426232
Palanki R, Riley JS, Bose SK, et al. (2024) In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 121: e2400783121
Han X, Alameh MG, Gong N, et al. (2024) Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo. Nature Chemistry
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