David O. Okonkwo, Ph.D. - Publications

Affiliations: 
Virginia Commonwealth University, Richmond, VA, United States 

164 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Yue JK, Yuh EL, Elguindy MM, Sun X, Van Essen TA, Deng H, Belton PJ, Satris GG, Wong JC, Valadka A, Korley FK, Robertson CS, McCrea M, Stein MB, Diaz-Arrastia R, ... ... Okonkwo DO, et al. Isolated Traumatic Subarachnoid Hemorrhage on Head Computed Tomography Scan May Not Be Isolated: A TRACK-TBI Study. Journal of Neurotrauma. PMID 38450561 DOI: 10.1089/neu.2023.0253  0.391
2024 Puccio AM, Yue JK, Korley FK, Okonkwo DO, Diaz-Arrastia R, Yuh EL, Ferguson AR, Mukherjee P, Wang KKW, Taylor S, Deng H, Markowitz AJ, Sun X, Jain S, Manley GT. Diagnostic Utility of Glial Fibrillary Acidic Protein Beyond 12 Hours After Traumatic Brain Injury: A TRACK-TBI Study. Journal of Neurotrauma. PMID 38251868 DOI: 10.1089/neu.2023.0186  0.33
2023 MacLean MA, Muradov JH, Greene R, Van Hameren G, Clarke DB, Dreier JP, Okonkwo DO, Friedman A. Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury. Science Advances. 9: eadj2417. PMID 38091390 DOI: 10.1126/sciadv.adj2417  0.357
2023 Etemad LL, Yue JK, Barber J, Nelson LD, Bodien YG, Satris GG, Belton PJ, Madhok DY, Huie JR, Hamidi S, Tracey JX, Coskun BC, Wong JC, Yuh EL, Mukherjee P, ... ... Okonkwo DO, et al. Longitudinal Recovery Following Repetitive Traumatic Brain Injury. Jama Network Open. 6: e2335804. PMID 37751204 DOI: 10.1001/jamanetworkopen.2023.35804  0.434
2023 Deng H, Puccio DJ, Anand SK, Yue JK, Hudson JS, Legarreta AD, Wei Z, Okonkwo DO, Puccio AM, Nwachuku EL. Power Drill Craniostomy for Bedside Intracranial Access in Traumatic Brain Injury Patients. Diagnostics (Basel, Switzerland). 13. PMID 37510178 DOI: 10.3390/diagnostics13142434  0.316
2023 Robbins EM, Jaquins-Gerstl AS, Okonkwo DO, Boutelle MG, Michael AC. Dexamethasone-Enhanced Continuous Online Microdialysis for Neuromonitoring of O after Brain Injury. Acs Chemical Neuroscience. PMID 37369003 DOI: 10.1021/acschemneuro.2c00703  0.397
2023 Brett BL, Temkin N, Barber JK, Okonkwo DO, Stein M, Bodien YG, Corrigan J, Diaz-Arrastia R, Giacino JT, McCrea MA, Manley GT, Nelson L. Long-term Multi-domain Patterns of Change Following Traumatic Brain Injury: A TRACK-TBI LONG Study. Neurology. PMID 37344231 DOI: 10.1212/WNL.0000000000207501  0.392
2023 Chesnut RM, Aguilera S, Buki A, Bulger EM, Citerio G, Cooper DJ, Arrastia RD, Diringer M, Figaji A, Gao G, Geocadin RG, Ghajar J, Harris O, Hawryluk GWJ, Hoffer A, ... ... Okonkwo DO, et al. Perceived Utility of Intracranial Pressure Monitoring in Traumatic Brain Injury: A Seattle International Brain Injury Consensus Conference Consensus-Based Analysis and Recommendations. Neurosurgery. PMID 37171175 DOI: 10.1227/neu.0000000000002516  0.367
2023 Pease M, Elmer J, Shahabadi AZ, Mallela AN, Ruiz-Rodriguez JF, Sexton D, Barot N, Gonzalez-Martinez JA, Shutter L, Okonkwo DO, Castellano JF. Predicting post-traumatic epilepsy using admission electroencephalography after severe traumatic brain injury. Epilepsia. PMID 37073101 DOI: 10.1111/epi.17622  0.394
2023 Pease M, Mallela AN, Elmer J, Okonkwo DO, Shutter L, Barot N, Gonzalez-Martinez J, Castellano JF. Association of Posttraumatic Epilepsy With Long-term Functional Outcomes in Individuals With Severe Traumatic Brain Injury. Neurology. PMID 36948595 DOI: 10.1212/WNL.0000000000207183  0.374
2023 Nelson LD, Temkin NR, Barber J, Brett BL, Okonkwo DO, McCrea MA, Giacino JT, Bodien YG, Robertson C, Corrigan JD, Diaz-Arrastia R, Markowitz AJ, Manley GT. Functional Recovery, Symptoms, and Quality of Life 1 to 5 Years After Traumatic Brain Injury. Jama Network Open. 6: e233660. PMID 36939699 DOI: 10.1001/jamanetworkopen.2023.3660  0.378
2023 Yue JK, Krishnan N, Kanter JH, Deng H, Okonkwo DO, Puccio AM, Madhok DY, Belton PJ, Lindquist BE, Satris GG, Lee YM, Umbach G, Duhaime AC, Mukherjee P, Yuh EL, et al. Neuroworsening in the Emergency Department Is a Predictor of Traumatic Brain Injury Intervention and Outcome: A TRACK-TBI Pilot Study. Journal of Clinical Medicine. 12. PMID 36902811 DOI: 10.3390/jcm12052024  0.424
2023 Eagle SR, Nwachuku E, Elmer J, Deng H, Okonkwo DO, Pease M. Performance of CRASH and IMPACT Prognostic Models for Traumatic Brain Injury at 12 and 24 Months Post-Injury. Neurotrauma Reports. 4: 118-123. PMID 36895818 DOI: 10.1089/neur.2022.0082  0.366
2023 Barton DJ, Coppler PJ, Talia NN, Charalambides A, Stancil B, Puccio AM, Okonkwo DO, Callaway CW, Guyette FX, Elmer J. Prehospital electroencephalography to detect traumatic brain injury during helicopter transport: a pilot observational cohort study. Prehospital Emergency Care. 1-10. PMID 36857200 DOI: 10.1080/10903127.2023.2185333  0.336
2022 Eagle SR, Okonkwo DO. In Reply: Prognostic Models for Traumatic Brain Injury Have Good Discrimination But Poor Overall Model Performance for Predicting Mortality and Unfavorable Outcomes. Neurosurgery. PMID 36700676 DOI: 10.1227/neu.0000000000002321  0.316
2022 Gardner RC, Puccio AM, Korley FK, Wang KKW, Diaz-Arrastia R, Okonkwo DO, Puffer RC, Yuh EL, Yue JK, Sun X, Taylor SR, Mukherjee P, Jain S, Manley GT. Effects of age and time since injury on traumatic brain injury blood biomarkers: a TRACK-TBI study. Brain Communications. 5: fcac316. PMID 36642999 DOI: 10.1093/braincomms/fcac316  0.422
2022 Agarwal N, Wilkins TE, Nwachuku EL, Deng H, Algattas H, Lavadi RS, Chang YF, Puccio A, Okonkwo DO. Long-term Benefits for Younger Patients with Aggressive Immediate Intervention following Severe Traumatic Brain Injury: A Longitudinal Cohort Analysis of 175 Patients from a Prospective Registry. Clinical Neurology and Neurosurgery. 224: 107545. PMID 36584586 DOI: 10.1016/j.clineuro.2022.107545  0.401
2022 Enam N, Deng H, Race NS, Majid DS, Okonkwo DO, Franzese KM. Continuum of care and longitudinal recovery in a 17-year-old athlete with second impact syndrome. Brain Injury. 1-5. PMID 36519359 DOI: 10.1080/02699052.2022.2158227  0.315
2022 Maas AIR, Menon DK, Manley GT, Abrams M, Åkerlund C, Andelic N, Aries M, Bashford T, Bell MJ, Bodien YG, Brett BL, Büki A, Chesnut RM, Citerio G, Clark D, ... ... Okonkwo D, et al. Traumatic brain injury: progress and challenges in prevention, clinical care, and research. The Lancet. Neurology. PMID 36183712 DOI: 10.1016/S1474-4422(22)00309-X  0.348
2022 Kulbe JR, Jain S, Nelson LD, Korley FK, Mukherjee P, Sun X, Okonkwo DO, Giacino JT, Vassar MJ, Robertson CS, McCrea MA, Wang KKW, Temkin N, Mac Donald CL, Taylor SR, et al. Correction to: Association of day-of-injury plasma glial fibrillary acidic protein concentration and six-month posttraumatic stress disorder in patients with mild traumatic brain injury. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 36180785 DOI: 10.1038/s41386-022-01466-3  0.386
2022 Eagle SR, Pease M, Nwachuku E, Deng H, Okonkwo DO. Prognostic Models for Traumatic Brain Injury Have Good Discrimination but Poor Overall Model Performance for Predicting Mortality and Unfavorable Outcomes. Neurosurgery. PMID 36173200 DOI: 10.1227/neu.0000000000002150  0.389
2022 Cai LT, Brett BL, Palacios EM, Yuh EL, Bourla I, Wren-Jarvis J, Wang Y, Donald CM, Diaz-Arrastia R, Giacino JT, Okonkwo DO, Levin HS, Robertson CS, Temkin N, Markowitz AJ, et al. Emotional Resilience Predicts Preserved White Matter Microstructure following Mild Traumatic Brain Injury. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. PMID 36152948 DOI: 10.1016/j.bpsc.2022.08.015  0.375
2022 Deng H, Luy DD, Abou-Al-Shaar H, Yue JK, Zinn PO, Puccio AM, Okonkwo DO. Critical care for concomitant severe traumatic brain injury and acute spinal cord injury in the polytrauma patient: illustrative case. Journal of Neurosurgery. Case Lessons. 3. PMID 36130580 DOI: 10.3171/CASE21521  0.35
2022 Korley FK, Jain S, Sun X, Puccio AM, Yue JK, Gardner RC, Wang KKW, Okonkwo DO, Yuh EL, Mukherjee P, Nelson LD, Taylor SR, Markowitz AJ, Diaz-Arrastia R, Manley GT. Prognostic value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI cohort: an observational cohort study. The Lancet. Neurology. 21: 803-813. PMID 35963263 DOI: 10.1016/S1474-4422(22)00256-3  0.404
2022 Hawryluk GWJ, Selph S, Lumba-Brown A, Totten AM, Ghajar J, Aarabi B, Ecklund J, Shackelford S, Adams B, Adelson D, Armonda RA, Benjamin J, Boone D, Brody D, Dengler B, ... ... Okonkwo DO, et al. Rationale and Methods for Updated Guidelines for the Management of Penetrating Traumatic Brain Injury. Neurotrauma Reports. 3: 240-247. PMID 35919507 DOI: 10.1089/neur.2022.0008  0.331
2022 Deng H, Nwachuku EL, Wilkins TE, Yue JK, Fetzick A, Chang YF, Beers SR, Okonkwo DO, Puccio AM. Time to Follow Commands in Severe Traumatic Brain Injury Survivors With Favorable Recovery at 2 Years. Neurosurgery. PMID 35833650 DOI: 10.1227/neu.0000000000002087  0.401
2022 Kulbe JR, Jain S, Nelson LD, Korley FK, Mukherjee P, Sun X, Okonkwo DO, Giacino JT, Vassar MJ, Robertson CS, McCrea MA, Wang KKW, Temkin N, Mac Donald CL, Taylor SR, et al. Association of day-of-injury serum glial fibrillary acidic protein concentration and six-month posttraumatic stress disorder in patients with mild traumatic brain injury. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 35717463 DOI: 10.1038/s41386-022-01359-5  0.385
2022 Kals M, Kunzmann K, Parodi L, Radmanesh F, Wilson L, Izzy S, Anderson CD, Puccio AM, Okonkwo DO, Temkin N, Steyerberg EW, Stein MB, Manley GT, Maas AIR, Richardson S, et al. A genome-wide association study of outcome from traumatic brain injury. Ebiomedicine. 77: 103933. PMID 35301180 DOI: 10.1016/j.ebiom.2022.103933  0.401
2022 Foreman B, Lee H, Okonkwo DO, Strong AJ, Pahl C, Shutter LA, Dreier JP, Ngwenya LB, Hartings JA. The Relationship Between Seizures and Spreading Depolarizations in Patients with Severe Traumatic Brain Injury. Neurocritical Care. PMID 35174446 DOI: 10.1007/s12028-022-01441-2  0.32
2022 Pease M, Nwachuku E, Goldschmidt E, Elmer J, Okonkwo DO. Complications from Multi-modal Monitoring do not Affect Long-term Outcomes in Severe Traumatic Brain Injury. World Neurosurgery. PMID 35077890 DOI: 10.1016/j.wneu.2022.01.059  0.357
2022 Liu D, Zusman BE, Shaffer JR, Li Y, Arockiaraj AI, Liu S, Weeks DE, Desai SM, Kochanek PM, Puccio AM, Okonkwo DO, Conley YP, Jha RM. Decreased DNA Methylation of RGMA is Associated with Intracranial Hypertension After Severe Traumatic Brain Injury: An Exploratory Epigenome-Wide Association Study. Neurocritical Care. PMID 35028889 DOI: 10.1007/s12028-021-01424-9  0.341
2021 Wu J, Vodovotz Y, Abdelhamid S, Guyette FX, Yaffe MB, Gruen DS, Cyr A, Okonkwo DO, Kar UK, Krishnamoorthi N, Voinchet RG, Billiar IM, Yazer MH, Namas RA, Daley BJ, et al. Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses. Cell Reports. Medicine. 2: 100478. PMID 35028617 DOI: 10.1016/j.xcrm.2021.100478  0.362
2021 Burke J, Gugger J, Ding K, Kim JA, Foreman B, Yue JK, Puccio AM, Yuh EL, Sun X, Rabinowitz M, Vassar MJ, Taylor SR, Winkler EA, Deng H, McCrea M, ... ... Okonkwo DO, et al. Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury. Jama Network Open. 4: e2140191. PMID 34964854 DOI: 10.1001/jamanetworkopen.2021.40191  0.408
2021 Wang KK, Munoz Pareja JC, Mondello S, Diaz-Arrastia R, Wellington C, Kenney K, Puccio AM, Hutchison J, McKinnon N, Okonkwo DO, Yang Z, Kobeissy F, Tyndall JA, Büki A, Czeiter E, et al. Blood-based Traumatic Brain Injury Biomarkers - Clinical Utilities and Regulatory Pathways in the United States, Europe and Canada. Expert Review of Molecular Diagnostics. PMID 34783274 DOI: 10.1080/14737159.2021.2005583  0.367
2021 Deng H, Goldschmidt E, Nwachuku E, Yue JK, Angriman F, Wei Z, Agarwal N, Puccio AM, Okonkwo DO. Hydrocephalus and Cerebrospinal Fluid Analysis Following Severe Traumatic Brain Injury: Evaluation of a Prospective Cohort. Neurology International. 13: 527-534. PMID 34698266 DOI: 10.3390/neurolint13040052  0.427
2021 Williams JR, Nieblas-Bedolla E, Feroze A, Young C, Temkin NR, Giacino JT, Okonkwo DO, Manley GT, Barber J, Durfy S, Markowitz AJ, Yuh EL, Mukherjee P, Mac Donald CL. Correction to: Prognostic Value of Hemorrhagic Brainstem Injury on Early Computed Tomography: A TRACK-TBI Study. Neurocritical Care. PMID 34591257 DOI: 10.1007/s12028-021-01356-4  0.31
2021 Hergenroeder GW, Yokobori S, Choi HA, Schmitt K, Detry MA, Schmitt LH, McGlothlin A, Puccio AM, Jagid J, Kuroda Y, Nakamura Y, Suehiro E, Ahmad F, Viele K, Wilde EA, ... ... Okonkwo DO, et al. Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: A Multicenter Randomized Clinical Trial. Neurocritical Care. PMID 34518968 DOI: 10.1007/s12028-021-01334-w  0.374
2021 Gifford EK, Robbins EM, Jaquins-Gerstl A, Rerick MT, Nwachuku EL, Weber SG, Boutelle MG, Okonkwo DO, Puccio AM, Michael AC. Validation of Dexamethasone-Enhanced Continuous-Online Microdialysis for Monitoring Glucose for 10 Days after Brain Injury. Acs Chemical Neuroscience. PMID 34506125 DOI: 10.1021/acschemneuro.1c00231  0.341
2021 McCrea MA, Cramer SC, Okonkwo DO, Mattke S, Paadre S, Bates D, Nejadnik B, Giacino JT. Determining Minimally Clinically Important Differences for Outcome Measures in Patients with Chronic Motor Deficits Secondary to Traumatic Brain Injury. Expert Review of Neurotherapeutics. PMID 34402352 DOI: 10.1080/14737175.2021.1968299  0.313
2021 Williams JR, Nieblas-Bedolla E, Feroze A, Young C, Temkin NR, Giacino JT, Okonkwo DO, Manley GT, Barber J, Durfy S, Markowitz AJ, Yu EL, Mukherjee P, Mac Donald CL. Prognostic Value of Hemorrhagic Brainstem Injury on Early Computed Tomography: A TRACK-TBI Study. Neurocritical Care. PMID 34309784 DOI: 10.1007/s12028-021-01263-8  0.413
2021 Jha RM, Zusman BE, Puccio AM, Okonkwo DO, Pease M, Desai SM, Leach M, Conley YP, Kochanek PM. Genetic Variants Associated With Intraparenchymal Hemorrhage Progression After Traumatic Brain Injury. Jama Network Open. 4: e2116839. PMID 34309670 DOI: 10.1001/jamanetworkopen.2021.16839  0.364
2021 Yuh EL, Jain S, Sun X, Pisica D, Harris MH, Taylor SR, Markowitz AJ, Mukherjee P, Verheyden J, Giacino JT, Levin HS, McCrea M, Stein MB, Temkin NR, Diaz-Arrastia R, ... ... Okonkwo DO, et al. Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI. Jama Neurology. PMID 34279565 DOI: 10.1001/jamaneurol.2021.2120  0.322
2021 McCrea MA, Giacino JT, Barber J, Temkin NR, Nelson LD, Levin HS, Dikmen S, Stein M, Bodien YG, Boase K, Taylor SR, Vassar M, Mukherjee P, Robertson C, Diaz-Arrastia R, ... Okonkwo DO, et al. Functional Outcomes Over the First Year After Moderate to Severe Traumatic Brain Injury in the Prospective, Longitudinal TRACK-TBI Study. Jama Neurology. PMID 34228047 DOI: 10.1001/jamaneurol.2021.2043  0.4
2021 Yue JK, Phelps RR, Hemmerle DD, Upadhyayula PS, Winkler EA, Deng H, Chang D, Vassar MJ, Taylor SR, Schnyer DM, Lingsma HF, Puccio AM, Yuh EL, Mukherjee P, Huang MC, ... ... Okonkwo DO, et al. Predictors of six-month inability to return to work in previously employed subjects after mild traumatic brain injury: A TRACK-TBI pilot study. Journal of Concussion. 5. PMID 34046212 DOI: 10.1177/20597002211007271  0.375
2021 Levin HS, Temkin NR, Barber J, Nelson LD, Robertson C, Brennan J, Stein MB, Yue JK, Giacino JT, McCrea MA, Diaz-Arrastia R, Mukherjee P, Okonkwo DO, Boase K, Markowitz AJ, et al. Association of Sex and Age With Mild Traumatic Brain Injury-Related Symptoms: A TRACK-TBI Study. Jama Network Open. 4: e213046. PMID 33822070 DOI: 10.1001/jamanetworkopen.2021.3046  0.367
2021 Brett BL, Kramer MD, Whyte J, McCrea MA, Stein MB, Giacino JT, Sherer M, Markowitz AJ, Manley GT, Nelson LD, Adeoye O, Badjatia N, Boase K, Barber J, ... ... Okonkwo D, et al. Latent Profile Analysis of Neuropsychiatric Symptoms and Cognitive Function of Adults 2 Weeks After Traumatic Brain Injury: Findings From the TRACK-TBI Study. Jama Network Open. 4: e213467. PMID 33783518 DOI: 10.1001/jamanetworkopen.2021.3467  0.392
2021 Zuckerman SL, Yengo-Kahn AM, Tang AR, Bailes JE, Beauchamp K, Berger MS, Bonfield CM, Camarata PJ, Cantu RC, Davis GA, Ellenbogen RG, Ellis MJ, Feuer H, Guazzo E, Harris OA, ... ... Okonkwo DO, et al. Sport-Related Structural Brain Injury and Return to Play: Systematic Review and Expert Insight. Neurosurgery. PMID 33693899 DOI: 10.1093/neuros/nyab041  0.397
2021 Smith DH, Dollé JP, Ameen-Ali KE, Bretzin A, Cortes E, Crary JF, Dams-O'Connor K, Diaz-Arrastia R, Edlow BL, Folkerth R, Hazrati LN, Hinds SR, Iacono D, Johnson VE, Keene CD, ... ... Okonkwo DO, et al. COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI). Acta Neuropathologica Communications. 9: 32. PMID 33648593 DOI: 10.1186/s40478-021-01122-9  0.356
2020 Yue JK, Satris GG, Dalle Ore CL, Huie JR, Deng H, Winkler EA, Lee YM, Vassar MJ, Taylor SR, Schnyer DM, Lingsma HF, Puccio AM, Yuh EL, Mukherjee P, Valadka AB, ... ... Okonkwo DO, et al. Polytrauma Is Associated with Increased Three- and Six-Month Disability after Traumatic Brain Injury: A TRACK-TBI Pilot Study. Neurotrauma Reports. 1: 32-41. PMID 34223528 DOI: 10.1089/neur.2020.0004  0.367
2020 Stein MB, Yuh E, Jain S, Okonkwo DO, Mac Donald CL, Levin H, Giacino JT, Dikmen S, Vassar MJ, Diaz-Arrastia R, Robertson CS, Nelson LD, McCrea M, Sun X, Temkin N, et al. Smaller Regional Brain Volumes Predict Posttraumatic Stress Disorder at 3 Months After Mild Traumatic Brain Injury. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. PMID 33386283 DOI: 10.1016/j.bpsc.2020.10.008  0.337
2020 Xu L, Yue JK, Korley FK, Puccio AM, Yuh EL, Sun X, Rabinowitz M, Vassar M, Taylor SR, Winkler EA, Puffer R, Deng H, McCrea M, Stein MB, Robertson CS, ... ... Okonkwo DO, et al. High-sensitivity C-Reactive Protein is a Prognostic Biomarker of 6-month Disability After Traumatic Brain Injury: Results from the TRACK-TBI Study. Journal of Neurotrauma. PMID 33161875 DOI: 10.1089/neu.2020.7177  0.393
2020 Gruen DS, Guyette FX, Brown JB, Okonkwo DO, Puccio AM, Campwala IK, Tessmer MT, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Phelan HA, Neal MD, Zuckerbraun BS, Yazer MH, et al. Association of Prehospital Plasma With Survival in Patients With Traumatic Brain Injury: A Secondary Analysis of the PAMPer Cluster Randomized Clinical Trial. Jama Network Open. 3: e2016869. PMID 33057642 DOI: 10.1001/jamanetworkopen.2020.16869  0.361
2020 Zusman BE, Kochanek PM, Bailey ZS, Leung LY, Vagni VA, Okonkwo DO, Puccio AM, Shutter LA, Janesko-Feldman KL, Gilsdorf JS, Shear DA, Jha RM. Multifaceted Benefit of Whole Blood Versus Lactated Ringer's Resuscitation After Traumatic Brain Injury and Hemorrhagic Shock in Mice. Neurocritical Care. PMID 32886294 DOI: 10.1007/S12028-020-01084-1  0.349
2020 Puffer RC, Cumba Garcia LM, Himes BT, Jung MY, Meyer FB, Okonkwo DO, Parney IF. Plasma extracellular vesicles as a source of biomarkers in traumatic brain injury. Journal of Neurosurgery. 1-8. PMID 32707544 DOI: 10.3171/2020.4.JNS20305  0.418
2020 Deng H, Yue JK, Zusman BE, Nwachuku EL, Abou-Al-Shaar H, Upadhyayula PS, Okonkwo DO, Puccio AM. B-Cell Lymphoma 2 (Bcl-2) and Regulation of Apoptosis after Traumatic Brain Injury: A Clinical Perspective. Medicina (Kaunas, Lithuania). 56. PMID 32570722 DOI: 10.3390/medicina56060300  0.424
2020 Mellett K, Ren D, Alexander S, Osier N, Beers SR, Okonkwo DO, Puccio AM, Conley YP. Genetic Variation in the Gene and Patient Outcomes Following Severe Traumatic Brain Injury. Biological Research For Nursing. 1099800420912335. PMID 32207313 DOI: 10.1177/1099800420912335  0.333
2020 Yue JK, Phelps RRL, Winkler EA, Deng H, Upadhyayula PS, Vassar MJ, Madhok DY, Schnyer DM, Puccio AM, Lingsma HF, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Manley GT, et al. Substance use on admission toxicology screen is associated with peri-injury factors and six-month outcome after traumatic brain injury: A TRACK-TBI Pilot study. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. PMID 32173156 DOI: 10.1016/J.Jocn.2020.02.021  0.342
2020 Goldschmidt E, Deng H, Puccio AM, Okonkwo DO. Post-traumatic hydrocephalus following decompressive hemicraniectomy: Incidence and risk factors in a prospective cohort of severe TBI patients. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. PMID 31987632 DOI: 10.1016/j.jocn.2020.01.027  0.369
2020 Chesnut R, Aguilera S, Buki A, Bulger E, Citerio G, Cooper DJ, Arrastia RD, Diringer M, Figaji A, Gao G, Geocadin R, Ghajar J, Harris O, Hoffer A, Hutchinson P, ... ... Okonkwo D, et al. A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC). Intensive Care Medicine. PMID 31965267 DOI: 10.1007/S00134-019-05900-X  0.309
2019 Hartings JA, Andaluz N, Bullock MR, Hinzman JM, Mathern B, Pahl C, Puccio A, Shutter LA, Strong AJ, Vagal A, Wilson JA, Dreier JP, Ngwenya LB, Foreman B, Pahren L, ... ... Okonkwo DO, et al. Prognostic Value of Spreading Depolarizations in Patients With Severe Traumatic Brain Injury. Jama Neurology. PMID 31886870 DOI: 10.1001/Jamaneurol.2019.4476  0.379
2019 Picetti E, Rossi S, Abu-Zidan FM, Ansaloni L, Armonda R, Baiocchi GL, Bala M, Balogh ZJ, Berardino M, Biffl WL, Bouzat P, Buki A, Ceresoli M, Chesnut RM, Chiara O, ... ... Okonkwo DO, et al. WSES consensus conference guidelines: monitoring and management of severe adult traumatic brain injury patients with polytrauma in the first 24 hours. World Journal of Emergency Surgery : Wjes. 14: 53. PMID 31798673 DOI: 10.1186/s13017-019-0270-1  0.344
2019 Hawryluk GWJ, Aguilera S, Buki A, Bulger E, Citerio G, Cooper DJ, Arrastia RD, Diringer M, Figaji A, Gao G, Geocadin R, Ghajar J, Harris O, Hoffer A, Hutchinson P, ... ... Okonkwo D, et al. A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC). Intensive Care Medicine. PMID 31659383 DOI: 10.1007/S00134-019-05805-9  0.333
2019 Yue JK, Yuh EL, Korley FK, Winkler EA, Sun X, Puffer RC, Deng H, Choy W, Chandra A, Taylor SR, Ferguson AR, Huie JR, Rabinowitz M, Puccio AM, Mukherjee P, ... ... Okonkwo DO, et al. Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study. The Lancet. Neurology. PMID 31451409 DOI: 10.1016/S1474-4422(19)30282-0  0.337
2019 Shuttleworth CW, Andrew RD, Akbari Y, Ayata C, Balu R, Brennan KC, Boutelle M, Carlson AP, Dreier JP, Fabricius M, Farkas E, Foreman B, Helbok R, Henninger N, Jewell SL, ... ... Okonkwo D, et al. Which Spreading Depolarizations Are Deleterious To Brain Tissue? Neurocritical Care. PMID 31388871 DOI: 10.1007/S12028-019-00776-7  0.342
2019 Osier ND, Ziari M, Puccio AM, Poloyac S, Okonkwo DO, Minnigh MB, Beers SR, Conley YP. Elevated cerebrospinal fluid concentrations of N-acetylaspartate correlate with poor outcome in a pilot study of severe brain trauma. Brain Injury. 1-8. PMID 31305157 DOI: 10.1080/02699052.2019.1641743  0.311
2019 Wilkins T, Beers SR, Hricik AJ, Brooks J, Mesley M, Puffer R, Chang Y, Okonkwo DO, Puccio AM. Favorable Functional Recovery in Severe Traumatic Brain Injury Survivors Beyond Six Months. Journal of Neurotrauma. PMID 31210093 DOI: 10.1089/neu.2018.6153  0.305
2019 Nelson LD, Temkin NR, Dikmen S, Barber J, Giacino JT, Yuh E, Levin HS, McCrea MA, Stein MB, Mukherjee P, Okonkwo DO, Diaz-Arrastia R, Manley GT, Adeoye O, et al. Recovery After Mild Traumatic Brain Injury in Patients Presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study. Jama Neurology. PMID 31157856 DOI: 10.1001/Jamaneurol.2019.1313  0.427
2019 Hutchinson PJ, Kolias AG, Tajsic T, Adeleye A, Aklilu AT, Apriawan T, Bajamal AH, Barthélemy EJ, Devi BI, Bhat D, Bulters D, Chesnut R, Citerio G, Cooper DJ, Czosnyka M, ... ... Okonkwo DO, et al. Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury : Consensus statement. Acta Neurochirurgica. PMID 31134383 DOI: 10.1007/S00701-019-03936-Y  0.392
2019 Eriksen N, Pakkenberg B, Rostrup E, Okonkwo DO, Mathern B, Shutter LA, Strong AJ, Woitzik J, Pahl C, Dreier JP, Martus P, Lauritzen MJ, Fabricius M, Hartings JA. Neurostereologic Lesion Volumes and Spreading Depolarizations in Severe Traumatic Brain Injury Patients: A Pilot Study. Neurocritical Care. PMID 30972614 DOI: 10.1007/S12028-019-00692-W  0.376
2019 Gardner RC, Cheng J, Ferguson AR, Boylan R, Boscardin WJ, Zafonte RD, Manley GT, Bagiella E, Ansel BM, Novack TA, Friedewald WT, Hesdorffer DC, Timmons S, Jallo J, Eisenberg H, ... ... Okonkwo DO, et al. Divergent 6-Month Functional Recovery Trajectories and Predictors after Traumatic Brain Injury: Novel Insights from the COBRIT Study. Journal of Neurotrauma. PMID 30909795 DOI: 10.1089/Neu.2018.6167  0.349
2019 Puffer RC, Yue JK, Mesley M, Billigen JB, Sharpless J, Fetzick AL, Puccio AM, Diaz-Arrastia R, Okonkwo DO. Recovery trajectories and long-term outcomes in traumatic brain injury: A secondary analysis of the phase 3 COBRIT clinical trial. World Neurosurgery. PMID 30763755 DOI: 10.1016/J.Wneu.2019.01.207  0.387
2018 Seabury SA, Gaudette É, Goldman DP, Markowitz AJ, Brooks J, McCrea MA, Okonkwo DO, Manley GT, Adeoye O, Badjatia N, Boase K, Bodien Y, Bullock MR, Chesnut R, et al. Assessment of Follow-up Care After Emergency Department Presentation for Mild Traumatic Brain Injury and Concussion: Results From the TRACK-TBI Study. Jama Network Open. 1: e180210. PMID 30646055 DOI: 10.1001/jamanetworkopen.2018.0210  0.391
2018 Yue JK, Winkler EA, Puffer RC, Deng H, Phelps RRL, Wagle S, Morrissey MR, Rivera EJ, Runyon SJ, Vassar MJ, Taylor SR, Cnossen MC, Lingsma HF, Yuh EL, Mukherjee P, ... ... Okonkwo DO, et al. Temporal lobe contusions on computed tomography are associated with impaired 6-month functional recovery after mild traumatic brain injury: a TRACK-TBI study. Neurological Research. 1-10. PMID 30175944 DOI: 10.1080/01616412.2018.1505416  0.414
2018 Jha RM, Elmer J, Zusman BE, Desai S, Puccio AM, Okonkwo DO, Park SY, Shutter LA, Wallisch JS, Conley YP, Kochanek PM. Intracranial Pressure Trajectories: A Novel Approach to Informing Severe Traumatic Brain Injury Phenotypes. Critical Care Medicine. PMID 30119071 DOI: 10.1097/Ccm.0000000000003361  0.374
2018 Huie JR, Diaz-Arrastia R, Yue JK, Sorani M, Puccio A, Okonkwo DO, Manley GT, Ferguson AR. TESTING A MULTIVARIATE PROTEOMIC PANEL FOR TBI BIOMARKER DISCOVERY: A TRACK-TBI PILOT STUDY. Journal of Neurotrauma. PMID 30084741 DOI: 10.1089/Neu.2017.5449  0.458
2018 Bazarian JJ, Biberthaler P, Welch RD, Lewis LM, Barzo P, Bogner-Flatz V, Gunnar Brolinson P, Büki A, Chen JY, Christenson RH, Hack D, Huff JS, Johar S, Jordan JD, Leidel BA, ... ... Okonkwo DO, et al. Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study. The Lancet. Neurology. PMID 30054151 DOI: 10.1016/S1474-4422(18)30231-X  0.369
2018 Yue JK, Rick JW, Morrissey MR, Taylor SR, Deng H, Suen CG, Vassar MJ, Cnossen MC, Lingsma HF, Yuh EL, Mukherjee P, Gardner RC, Valadka AB, Okonkwo DO, Cage TA, et al. Preinjury employment status as a risk factor for symptomatology and disability in mild traumatic brain injury: A TRACK-TBI analysis. Neurorehabilitation. PMID 30040754 DOI: 10.3233/Nre-172375  0.421
2018 Si B, Dumkrieger G, Wu T, Zafonte R, Valadka AB, Okonkwo DO, Manley GT, Wang L, Dodick DW, Schwedt TJ, Li J. Sub-classifying patients with mild traumatic brain injury: A clustering approach based on baseline clinical characteristics and 90-day and 180-day outcomes. Plos One. 13: e0198741. PMID 29995912 DOI: 10.1371/Journal.Pone.0198741  0.348
2018 Stocchetti N, Poole D, Okonkwo DO. Intracranial pressure thresholds in severe traumatic brain injury: we are not sure : Prudent clinical practice despite dogma or nihilism. Intensive Care Medicine. PMID 29978390 DOI: 10.1007/s00134-018-5251-4  0.358
2018 Osier N, Conley YP, Okonkwo DO, Puccio AM. Variation in candidate TBI biomarker genes are associated with gross neurological outcomes after severe TBI. Journal of Neurotrauma. PMID 29969943 DOI: 10.1089/Neu.2017.5268  0.302
2018 Ngwenya LB, Gardner RC, Yue JK, Burke JF, Ferguson AR, Huang MC, Winkler EA, Pirracchio R, Satris GG, Yuh EL, Mukherjee P, Valadka AB, Okonkwo DO, Manley GT. Concordance of common data elements for assessment of subjective cognitive complaints after mild-traumatic brain injury: a TRACK-TBI Pilot Study. Brain Injury. 1-8. PMID 29863894 DOI: 10.1080/02699052.2018.1481527  0.347
2018 Korley FK, Yue JK, Wilson D, Hrusovsky K, Diaz-Arrasta R, Ferguson AR, Yuh EL, Mukherjee P, Wang KKW, Valadka A, Puccio A, Okonkwo DO, Manley G. Performance Evaluation of a Multiplex Assay for Simultaneous Detection of Four Clinically Relevant TBI Biomarkers. Journal of Neurotrauma. PMID 29690824 DOI: 10.1089/Neu.2017.5623  0.302
2018 Jha RM, Koleck TA, Puccio AM, Okonkwo DO, Park SY, Zusman BE, Clark RSB, Shutter LA, Wallisch JS, Empey PE, Kochanek PM, Conley YP. Regionally clustered polymorphisms in a prospective cohort predict cerebral oedema and outcome in severe traumatic brain injury. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 29674479 DOI: 10.1136/Jnnp-2017-317741  0.351
2018 Fehlings MG, Kim KD, Aarabi B, Rizzo M, Bond LM, McKerracher L, Vaccaro A, Okonkwo DO. Rho Inhibitor VX-210 in Acute Traumatic Subaxial Cervical Spinal Cord Injury: Design of the SPinal Cord Injury Rho INhibition InvestiGation (SPRING) Clinical Trial. Journal of Neurotrauma. PMID 29316845 DOI: 10.1089/Neu.2017.5434  0.325
2017 Alarcon JD, Rubiano AM, Okonkwo DO, Alarcón J, Martinez-Zapata MJ, Urrútia G, Bonfill Cosp X. Elevation of the head during intensive care management in people with severe traumatic brain injury. The Cochrane Database of Systematic Reviews. 12: CD009986. PMID 29283434 DOI: 10.1002/14651858.CD009986.pub2  0.386
2017 Yue JK, Winkler EA, Sharma S, Vassar MJ, Ratcliff JJ, Korley FK, Seabury SA, Ferguson AR, Lingsma HF, Meeuws S, Adeoye OM, Rick JW, Robinson CK, Duarte SM, Yuh EL, ... ... Okonkwo DO, et al. Temporal profile of care following mild traumatic brain injury: predictors of hospital admission, follow-up referral and six-month outcome. Brain Injury. 31: 1820-1829. PMID 29166203 DOI: 10.1080/02699052.2017.1351000  0.377
2017 Albayram O, Kondo A, Mannix R, Smith C, Tsai CY, Li C, Herbert MK, Qiu J, Monuteaux M, Driver J, Yan S, Gormley W, Puccio AM, Okonkwo DO, Lucke-Wold B, et al. Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae. Nature Communications. 8: 1000. PMID 29042562 DOI: 10.1038/S41467-017-01068-4  0.394
2017 Okonkwo DO, Shutter LA, Moore C, Temkin NR, Puccio AM, Madden CJ, Andaluz N, Chesnut RM, Bullock MR, Grant GA, McGregor J, Weaver M, Jallo J, LeRoux PD, Moberg D, et al. Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial. Critical Care Medicine. 45: 1907-1914. PMID 29028696 DOI: 10.1097/Ccm.0000000000002619  0.431
2017 Agoston D, Arun P, Bellgowan P, Broglio S, Cantu R, Cook D, da Silva UO, Dickstein D, Elder G, Fudge E, Gandy S, Gill J, Glenn JF, Gupta RK, Hinds S, ... ... Okonkwo D, et al. Military Blast Injury and Chronic Neurodegeneration: Research Presentations from the 2015 International State-of-the-Science Meeting. Journal of Neurotrauma. 34: S6-S17. PMID 28937955 DOI: 10.1089/Neu.2017.5220  0.365
2017 Yue JK, Ngwenya LB, Upadhyayula PS, Deng H, Winkler EA, Burke JF, Lee YM, Robinson CK, Ferguson AR, Lingsma HF, Cnossen MC, Pirracchio R, Korley FK, Vassar MJ, Yuh EL, ... ... Okonkwo DO, et al. Emergency department blood alcohol level associates with injury factors and six-month outcome after uncomplicated mild traumatic brain injury. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. PMID 28789959 DOI: 10.1016/J.Jocn.2017.07.022  0.333
2017 Adams SM, Conley YP, Ren D, Okonkwo DO, Puccio A, Dixon CE, Clark RS, Kochanek PM, Empey PE. ABCG2 c.421C>A is Associated with Outcomes Following Severe Traumatic Brain Injury. Journal of Neurotrauma. PMID 28747144 DOI: 10.1089/neu.2017.5000  0.346
2017 Rubenstein R, Chang B, Yue JK, Chiu A, Winkler EA, Puccio AM, Diaz-Arrastia R, Yuh EL, Mukherjee P, Valadka AB, Gordon WA, Okonkwo DO, Davies P, Agarwal S, Lin F, et al. Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau-Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers. Jama Neurology. PMID 28738126 DOI: 10.1001/Jamaneurol.2017.0655  0.411
2017 Parry PV, Choi PA, Bauer JS, Panczykowski DM, Puccio AM, Okonkwo DO. Utility of the Aspirin and P2Y12 Response Assays to Determine the Effect of Antiplatelet Agents on Platelet Reactivity in Traumatic Brain Injury. Neurosurgery. 80: 92-96. PMID 28362884 DOI: 10.1227/NEU.0000000000001406  0.398
2017 Nielson JL, Cooper SR, Yue JK, Sorani MD, Inoue T, Yuh EL, Mukherjee P, Petrossian TC, Paquette J, Lum PY, Carlsson GE, Vassar MJ, Lingsma HF, Gordon WA, Valadka AB, ... Okonkwo DO, et al. Uncovering precision phenotype-biomarker associations in traumatic brain injury using topological data analysis. Plos One. 12: e0169490. PMID 28257413 DOI: 10.1371/Journal.Pone.0169490  0.384
2016 Jha R, Puccio A, Okonkwo D, Zusman B, Wallisch J, Shutter L, Kochanek P, Conley Y. 738: ABCC8 TAG SINGLE NUCLEOTIDE POLYMORPHISMS CORRELATE WITH EDEMA AND OUTCOME IN TRAUMATIC BRAIN INJURY. Critical Care Medicine. 44: 260. PMID 27850376 DOI: 10.1097/01.Ccm.0000509414.75123.25  0.353
2016 Jha RM, Puccio AM, Chou SH, Chang CH, Wallisch JS, Molyneaux BJ, Zusman BE, Shutter LA, Poloyac SM, Janesko-Feldman KL, Okonkwo DO, Kochanek PM. Sulfonylurea Receptor-1: A Novel Biomarker for Cerebral Edema in Severe Traumatic Brain Injury. Critical Care Medicine. PMID 27845954 DOI: 10.1097/Ccm.0000000000002079  0.393
2016 Abboud A, Mi Q, Puccio A, Okonkwo D, Buliga M, Constantine G, Vodovotz Y. Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death. Frontiers in Pharmacology. 7: 342. PMID 27729864 DOI: 10.3389/Fphar.2016.00342  0.3
2016 Nwachuku EL, Puccio AM, Adeboye A, Chang YF, Kim J, Okonkwo DO. Time course of cerebrospinal fluid inflammatory biomarkers and relationship to 6-month neurologic outcome in adult severe traumatic brain injury. Clinical Neurology and Neurosurgery. 149: 1-5. PMID 27450760 DOI: 10.1016/j.clineuro.2016.06.009  0.367
2015 Winkler EA, Yue JK, McAllister TW, Temkin NR, Oh SS, Burchard EG, Hu D, Ferguson AR, Lingsma HF, Burke JF, Sorani MD, Rosand J, Yuh EL, Barber J, Tarapore PE, ... ... Okonkwo DO, et al. COMT Val (158) Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury. Neurogenetics. PMID 26576546 DOI: 10.1007/S10048-015-0467-8  0.325
2015 Wang KK, Yang Z, Yue JK, Zhang Z, Winkler EA, Puccio A, Diaz-Arrastia R, Lingsma H, Yuh EL, Mukherjee P, Valadka A, Gordon WA, Okonkwo DO, Manley GT. Plasma Anti-Glial Fibrillary Acidic Protein (GFAP) Autoantibody Levels During the Acute and Chronic Phases of Traumatic Brain Injury - A TRACK-TBI Pilot Study. Journal of Neurotrauma. PMID 26560343 DOI: 10.1089/Neu.2015.3881  0.337
2015 Yue JK, Winkler EA, McAllister TW, Temkin N, Ferguson A, Lingsma HF, Yuh E, Tarapore PE, Sharma S, Puccio A, Wang K, Mukherjee P, Valadka AB, Okonkwo DO, Diaz-Arrastia R, et al. 178 COMT Val158Met is Associated With Domain-Specific Cognitive Impairment Following Mild Traumatic Brain Injury. Neurosurgery. 62: 225. PMID 26182024 DOI: 10.1227/01.Neu.0000467142.58514.77  0.329
2015 Korley FK, Diaz-Arrastia R, Wu AH, Yue JK, Manley GT, Sair HI, Van Eyk J, Everett AD, Okonkwo DO, Valadka A, Gordon WA, Maas A, Mukherjee P, Yuh EL, Lingsma H, et al. Circulating Brain Derived Neurotrophic Factor (BDNF) Has Diagnostic and Prognostic Value in Traumatic Brain Injury. Journal of Neurotrauma. PMID 26159676 DOI: 10.1089/Neu.2015.3949  0.346
2015 Grandhi R, Shutter LA, Okonkwo DO. Risks and benefits of resumption of anticoagulation following traumatic brain injury remain complex and uncertain. Jama Internal Medicine. 175: 866. PMID 25938318 DOI: 10.1001/jamainternmed.2015.0298  0.388
2015 Willyerd FA, Empey PE, Philbrick A, Ikonomovic MD, Puccio AM, Kochanek PM, Okonkwo DO, Clark RS. Expression of ATP-Binding Cassette Transporters B1 and C1 after Severe Traumatic Brain Injury in Humans. Journal of Neurotrauma. PMID 25891836 DOI: 10.1089/Neu.2015.3879  0.34
2015 Chmura J, Presson N, Benso S, Puccio AM, Fissel K, Hachey R, Braun E, Okonkwo DO, Schneider W. A high-definition fiber tracking report for patients with traumatic brain injury and their doctors. Military Medicine. 180: 122-34. PMID 25747643 DOI: 10.7205/Milmed-D-14-00441  0.321
2015 Presson N, Krishnaswamy D, Wagener L, Bird W, Jarbo K, Pathak S, Puccio AM, Borasso A, Benso S, Okonkwo DO, Schneider W. Quantifying white matter structural integrity with high-definition fiber tracking in traumatic brain injury. Military Medicine. 180: 109-21. PMID 25747642 DOI: 10.7205/Milmed-D-14-00413  0.389
2015 Grandhi R, Harrison G, Voronovich Z, Bauer J, Chen SH, Nicholas D, Alarcon LH, Okonkwo DO. Preinjury warfarin, but not antiplatelet medications, increases mortality in elderly traumatic brain injury patients. The Journal of Trauma and Acute Care Surgery. 78: 614-21. PMID 25710435 DOI: 10.1097/TA.0000000000000542  0.345
2015 McMahon PJ, Panczykowski DM, Yue JK, Puccio AM, Inoue T, Sorani MD, Lingsma HF, Maas AI, Valadka AB, Yuh EL, Mukherjee P, Manley GT, Okonkwo DO, Casey SS, Cheong M, et al. Measurement of the glial fibrillary acidic protein and its breakdown products GFAP-BDP biomarker for the detection of traumatic brain injury compared to computed tomography and magnetic resonance imaging. Journal of Neurotrauma. 32: 527-33. PMID 25264814 DOI: 10.1089/Neu.2014.3635  0.395
2015 Lingsma HF, Yue JK, Maas AI, Steyerberg EW, Manley GT, Cooper SR, Dams-O'Connor K, Gordon WA, Menon DK, Mukherjee P, Okonkwo DO, Puccio AM, Schnyer DM, Valadka AB, et al. Outcome prediction after mild and complicated mild traumatic brain injury: external validation of existing models and identification of new predictors using the TRACK-TBI pilot study. Journal of Neurotrauma. 32: 83-94. PMID 25025611 DOI: 10.1089/Neu.2014.3384  0.339
2014 Grandhi R, Bonfield CM, Newman WC, Okonkwo DO. Surgical management of traumatic brain injury: a review of guidelines, pathophysiology, neurophysiology, outcomes, and controversies. Journal of Neurosurgical Sciences. 58: 249-59. PMID 25418276  0.316
2014 Shin SS, Dixon CE, Okonkwo DO, Richardson RM. Neurostimulation for traumatic brain injury. Journal of Neurosurgery. 121: 1219-31. PMID 25170668 DOI: 10.3171/2014.7.Jns131826  0.402
2014 Salibi PN, Agarwal V, Panczykowski DM, Puccio AM, Sheetz MA, Okonkwo DO. Lifetime attributable risk of cancer from CT among patients surviving severe traumatic brain injury. Ajr. American Journal of Roentgenology. 202: 397-400. PMID 24370078 DOI: 10.2214/AJR.12.10294  0.329
2014 McMahon P, Hricik A, Yue JK, Puccio AM, Inoue T, Lingsma HF, Beers SR, Gordon WA, Valadka AB, Manley GT, Okonkwo DO. Symptomatology and functional outcome in mild traumatic brain injury: results from the prospective TRACK-TBI study. Journal of Neurotrauma. 31: 26-33. PMID 23952719 DOI: 10.1089/Neu.2013.2984  0.347
2014 Nwachuku EL, Puccio AM, Fetzick A, Scruggs B, Chang YF, Shutter LA, Okonkwo DO. Intermittent versus continuous cerebrospinal fluid drainage management in adult severe traumatic brain injury: assessment of intracranial pressure burden. Neurocritical Care. 20: 49-53. PMID 23943318 DOI: 10.1007/s12028-013-9885-3  0.305
2014 Diaz-Arrastia R, Wang KK, Papa L, Sorani MD, Yue JK, Puccio AM, McMahon PJ, Inoue T, Yuh EL, Lingsma HF, Maas AI, Valadka AB, Okonkwo DO, Manley GT. Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein. Journal of Neurotrauma. 31: 19-25. PMID 23865516 DOI: 10.1089/Neu.2013.3040  0.356
2014 Panczykowski DM, Puccio A, Chang Y, Shutter LA, Okonkwo DO. 163 Brain Tissue Oxygenation and 3- and 6-month Neurological Outcome in Severe Traumatic Brain Injury Neurosurgery. 61: 213-214. DOI: 10.1227/01.neu.0000452438.67788.7b  0.365
2013 Dams-O'Connor K, Spielman L, Singh A, Gordon WA, Lingsma HF, Maas AI, Manley GT, Mukherjee P, Okonkwo DO, Puccio AM, Schnyer DM, Valadka AB, Yue JK, Yuh EL. The impact of previous traumatic brain injury on health and functioning: a TRACK-TBI study. Journal of Neurotrauma. 30: 2014-20. PMID 23924069 DOI: 10.1089/neu.2013.3049  0.402
2013 Cousar JL, Conley YP, Willyerd FA, Sarnaik AA, Puccio AM, Empey PE, Kochanek PM, Bell MJ, Okonkwo DO, Clark RS. Influence of ATP-binding cassette polymorphisms on neurological outcome after traumatic brain injury. Neurocritical Care. 19: 192-8. PMID 23896815 DOI: 10.1007/S12028-013-9881-7  0.31
2013 Yue JK, Vassar MJ, Lingsma HF, Cooper SR, Okonkwo DO, Valadka AB, Gordon WA, Maas AI, Mukherjee P, Yuh EL, Puccio AM, Schnyer DM, Manley GT. Transforming research and clinical knowledge in traumatic brain injury pilot: multicenter implementation of the common data elements for traumatic brain injury. Journal of Neurotrauma. 30: 1831-44. PMID 23815563 DOI: 10.1089/Neu.2013.2970  0.347
2013 Okonkwo DO, Yue JK, Puccio AM, Panczykowski DM, Inoue T, McMahon PJ, Sorani MD, Yuh EL, Lingsma HF, Maas AI, Valadka AB, Manley GT. GFAP-BDP as an acute diagnostic marker in traumatic brain injury: results from the prospective transforming research and clinical knowledge in traumatic brain injury study. Journal of Neurotrauma. 30: 1490-7. PMID 23489259 DOI: 10.1089/Neu.2013.2883  0.397
2013 Yuh EL, Mukherjee P, Lingsma HF, Yue JK, Ferguson AR, Gordon WA, Valadka AB, Schnyer DM, Okonkwo DO, Maas AI, Manley GT. Magnetic resonance imaging improves 3-month outcome prediction in mild traumatic brain injury. Annals of Neurology. 73: 224-35. PMID 23224915 DOI: 10.1002/Ana.23783  0.326
2012 Bonfield CM, Maserati MB, Okonkwo DO, Kanter AS. 147 Correlation between the Thoracolumbar Injury Classification and Severity Score (TLICS) and Delayed Surgery for Acute Thoracolumbar Compression and Burst Fractures in Patients without Neurologic Injury. Neurosurgery. 71: E559. PMID 28175804 DOI: 10.1227/01.neu.0000417737.01677.f7  0.321
2012 Ji J, Kline AE, Amoscato A, Samhan-Arias AK, Sparvero LJ, Tyurin VA, Tyurina YY, Fink B, Manole MD, Puccio AM, Okonkwo DO, Cheng JP, Alexander H, Clark RS, Kochanek PM, et al. Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury. Nature Neuroscience. 15: 1407-13. PMID 22922784 DOI: 10.1038/Nn.3195  0.357
2012 Clifton GL, Coffey CS, Fourwinds S, Zygun D, Valadka A, Smith KR, Frisby ML, Bucholz RD, Wilde EA, Levin HS, Okonkwo DO. Early induction of hypothermia for evacuated intracranial hematomas: a post hoc analysis of two clinical trials. Journal of Neurosurgery. 117: 714-20. PMID 22839656 DOI: 10.3171/2012.6.Jns111690  0.325
2012 Shin SS, Verstynen T, Pathak S, Jarbo K, Hricik AJ, Maserati M, Beers SR, Puccio AM, Boada FE, Okonkwo DO, Schneider W. High-definition fiber tracking for assessment of neurological deficit in a case of traumatic brain injury: finding, visualizing, and interpreting small sites of damage. Journal of Neurosurgery. 116: 1062-9. PMID 22381003 DOI: 10.3171/2012.1.Jns111282  0.484
2012 Hartings JA, Strong AJ, Okonkwo DO, Bullock MR. Spreading depolarisations and traumatic brain injury: time course and mechanisms – Authors' reply The Lancet Neurology. 11: 389-390. DOI: 10.1016/S1474-4422(12)70085-6  0.405
2012 Grandhi R, Okonkwo DO. Perioperative Management of Severe Traumatic Brain Injury in Adults Schmidek and Sweet Operative Neurosurgical Techniques: Indications, Methods, and Results: Sixth Edition. 2: 1495-1512. DOI: 10.1016/B978-1-4160-6839-6.10132-7  0.371
2011 Clifton MG, Valadka PA, Aisuku IP, Okonkwo DO. Future of rewarming in therapeutic hypothermia for traumatic brain injury: a personalized plan. Therapeutic Hypothermia and Temperature Management. 1: 3-7. PMID 24716882 DOI: 10.1089/ther.2010.1500  0.377
2011 Hartings JA, Bullock MR, Okonkwo DO, Murray LS, Murray GD, Fabricius M, Maas AI, Woitzik J, Sakowitz O, Mathern B, Roozenbeek B, Lingsma H, Dreier JP, Puccio AM, Shutter LA, et al. Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study. The Lancet. Neurology. 10: 1058-64. PMID 22056157 DOI: 10.1016/S1474-4422(11)70243-5  0.403
2011 Hartings JA, Watanabe T, Bullock MR, Okonkwo DO, Fabricius M, Woitzik J, Dreier JP, Puccio A, Shutter LA, Pahl C, Strong AJ. Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma. Brain : a Journal of Neurology. 134: 1529-40. PMID 21478187 DOI: 10.1093/Brain/Awr048  0.334
2011 Clifton GL, Valadka A, Zygun D, Coffey CS, Drever P, Fourwinds S, Janis LS, Wilde E, Taylor P, Harshman K, Conley A, Puccio A, Levin HS, McCauley SR, Bucholz RD, ... ... Okonkwo DO, et al. Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial. The Lancet. Neurology. 10: 131-9. PMID 21169065 DOI: 10.1016/S1474-4422(10)70300-8  0.389
2010 Dimar JR, Fisher C, Vaccaro AR, Okonkwo DO, Dvorak M, Fehlings M, Rampersaud R, Carreon LY. Predictors of complications after spinal stabilization of thoracolumbar spine injuries. The Journal of Trauma. 69: 1497-500. PMID 20404758 DOI: 10.1097/Ta.0B013E3181Cc853B  0.321
2010 Ochalski PG, Fellows-Mayle W, Hsieh LB, Srinivas R, Okonkwo DO, Dixon CE, Adelson PD. Flumazenil administration attenuates cognitive impairment in immature rats after controlled cortical impact. Journal of Neurotrauma. 27: 647-51. PMID 19929186 DOI: 10.1089/neu.2009.1142  0.302
2010 Dimar JR, Fisher CG, Vaccaro AR, Okonkwo DO, Dvorak MF, Fehlings MG, Rampersaud YR, Carreon LY. Predictors of Clinical Outcomes following Stabilization of Thoracolumbar Spine Injuries The Spine Journal. 10: S15-S16. DOI: 10.1016/J.Spinee.2010.07.045  0.308
2009 Namas R, Ghuma A, Hermus L, Zamora R, Okonkwo DO, Billiar TR, Vodovotz Y. The acute inflammatory response in trauma / hemorrhage and traumatic brain injury: current state and emerging prospects. The Libyan Journal of Medicine. 4: 97-103. PMID 21483522 DOI: 10.4176/090325  0.34
2009 Ochalski PG, Okonkwo DO, Bell MJ, Adelson PD. Reversal of sedation with flumazenil in a child after traumatic brain injury. Journal of Neurosurgery. Pediatrics. 3: 240-3. PMID 19338472 DOI: 10.3171/2008.12.PEDS08185  0.395
2009 Puccio AM, Fischer MR, Jankowitz BT, Yonas H, Darby JM, Okonkwo DO. Induced normothermia attenuates intracranial hypertension and reduces fever burden after severe traumatic brain injury. Neurocritical Care. 11: 82-7. PMID 19337864 DOI: 10.1007/S12028-009-9213-0  0.388
2009 Clifton GL, Drever P, Valadka A, Zygun D, Okonkwo D. Multicenter trial of early hypothermia in severe brain injury. Journal of Neurotrauma. 26: 393-7. PMID 19245306 DOI: 10.1089/neu.2008.0556  0.362
2009 Dimar J, Fisher C, Vaccaro A, Okonkwo D, Dvorak M, Fehlings M, Rampersaud R, Carreon L. 70. Predictors of Complications Following Spinal Stabilization of Thoracolumbar Spine Injuries The Spine Journal. 9: 35S-36S. DOI: 10.1016/J.Spinee.2009.08.085  0.309
2008 Jagannathan J, Okonkwo DO, Yeoh HK, Dumont AS, Saulle D, Haizlip J, Barth JT, Jane JA, Jane JA. Long-term outcomes and prognostic factors in pediatric patients with severe traumatic brain injury and elevated intracranial pressure. Journal of Neurosurgery. Pediatrics. 2: 240-9. PMID 18831656 DOI: 10.3171/PED.2008.2.10.240  0.308
2008 Rangel-Castilla L, Gasco J, Nauta HJ, Okonkwo DO, Robertson CS. Cerebral pressure autoregulation in traumatic brain injury. Neurosurgical Focus. 25: E7. PMID 18828705 DOI: 10.3171/FOC.2008.25.10.E7  0.303
2008 Okonkwo DO. Introduction: traumatic brain injury. Neurosurgical Focus. 25: E1. PMID 18828699 DOI: 10.3171/FOC.2008.25.10.E1  0.439
2007 Jagannathan J, Okonkwo DO, Dumont AS, Ahmed H, Bahari A, Prevedello DM, Jane JA, Jane JA. Outcome following decompressive craniectomy in children with severe traumatic brain injury: a 10-year single-center experience with long-term follow up. Journal of Neurosurgery. 106: 268-75. PMID 17465359 DOI: 10.3171/ped.2007.106.4.268  0.375
2006 Okonkwo DO, Reece TB, Laurent JJ, Hawkins AS, Ellman PI, Linden J, Kron IL, Tribble CG, Stone JR, Kern JA. A comparison of adenosine A2A agonism and methylprednisolone in attenuating neuronal damage and improving functional outcome after experimental traumatic spinal cord injury in rabbits. Journal of Neurosurgery. Spine. 4: 64-70. PMID 16506468 DOI: 10.3171/Spi.2006.4.1.64  0.475
2006 Puccio AM, Jankowitz BT, Fischer MR, Okonkwo DO. CONTROLLED NORMOTHERMIA ATTENUATES INTRACRANIAL HYPERTENSION AFTER SEVERE TRAUMATIC BRAIN INJURY. Critical Care Medicine. 34: A82. DOI: 10.1097/00003246-200612002-00284  0.401
2006 Fischer MR, Puccio AM, Stippler M, Carson-Walter E, Walter KA, Okonkwo DO. CORRELATION OF INITIAL CEREBROSPINAL FLUID MAGNESIUM LEVEL AND OUTCOME IN SEVERE TRAUMATIC BRAIN INJURY. Critical Care Medicine. 34: A17. DOI: 10.1097/00003246-200612002-00066  0.372
2005 Okonkwo DO, Katz AJ, Lee KS, Jane JA. Repopulation of injured brain with human adipo-derived stem cells after traumatic brain injury Journal of the American College of Surgeons. 201: S47. DOI: 10.1016/j.jamcollsurg.2005.06.101  0.346
2005 Mills JD, Stone JR, Okonkwo DO, Periasamy A, Helm GA. Multiphoton FRET Microscopy for Protein Localization in Tissue Molecular Imaging. 112-125. DOI: 10.1016/B978-019517720-6.50015-8  0.373
2004 Stone JR, Okonkwo DO, Dialo AO, Rubin DG, Mutlu LK, Povlishock JT, Helm GA. Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injury. Experimental Neurology. 190: 59-69. PMID 15473980 DOI: 10.1016/J.Expneurol.2004.05.022  0.76
2004 Reece TB, Davis JD, Okonkwo DO, Maxey TS, Ellman PI, Li X, Linden J, Tribble CG, Kron IL, Kern JA. Adenosine A2A analogue reduces long-term neurologic injury after blunt spinal trauma. The Journal of Surgical Research. 121: 130-4. PMID 15313386 DOI: 10.1016/J.Jss.2004.04.006  0.307
2004 Mills JD, Stone JR, Okonkwo DO, Periasamy A, Helm GA. Multiphoton tissue FRET demonstrates in vivo BAD/Bcl-xL heterodimerization in injured axons following traumatic brain injury in rats Proceedings of Spie - the International Society For Optical Engineering. 5323: 52-62. DOI: 10.1117/12.533830  0.701
2003 Okonkwo DO, Wagner J, Melon DE, Alden T, Stone JR, Helm GA, Jane JA. Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation Neuroscience Letters. 352: 97-100. PMID 14625032 DOI: 10.1016/j.neulet.2003.08.044  0.438
2003 Mills JD, Stone JR, Rubin DG, Melon DE, Okonkwo DO, Periasamy A, Helm GA. Illuminating protein interactions in tissue using confocal and two-photon excitation fluorescent resonance energy transfer microscopy. Journal of Biomedical Optics. 8: 347-56. PMID 12880338 DOI: 10.1117/1.1584443  0.635
2003 Okonkwo DO, Stone JR. Basic science of closed head injuries and spinal cord injuries Clinics in Sports Medicine. 22: 467-481. PMID 12852680 DOI: 10.1016/S0278-5919(02)00107-2  0.59
2003 Okonkwo DO, Melon DE, Pellicane AJ, Mutlu LK, Rubin DG, Stone JR, Helm GA. Dose-response of cyclosporin A in attenuating traumatic axonal injury in rat Neuroreport. 14: 463-466. PMID 12634504  0.69
2002 Stone JR, Okonkwo DO, Singleton RH, Mutlu LK, Helm GA, Povlishock JT. Caspase-3-mediated cleavage of amyloid precursor protein and formation of amyloid Beta peptide in traumatic axonal injury. Journal of Neurotrauma. 19: 601-14. PMID 12042095 DOI: 10.1089/089771502753754073  0.737
2001 Dumont RJ, Okonkwo DO, Verma S, Hurlbert RJ, Boulos PT, Ellegala DB, Dumont AS. Acute spinal cord injury, part I: Pathophysiologic mechanisms Clinical Neuropharmacology. 24: 254-264. PMID 11586110 DOI: 10.1097/00002826-200109000-00002  0.386
2001 Singleton RH, Stone JR, Okonkwo DO, Pellicane AJ, Povlishock JT. The immunophilin ligand FK506 attenuates axonal injury in an impact-acceleration model of traumatic brain injury. Journal of Neurotrauma. 18: 607-14. PMID 11437083 DOI: 10.1089/089771501750291846  0.753
2000 Büki A, Okonkwo DO, Wang KK, Povlishock JT. Cytochrome c release and caspase activation in traumatic axonal injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 2825-34. PMID 10751434 DOI: 10.1523/Jneurosci.20-08-02825.2000  0.688
1999 Povlishock JT, Buki A, Koiziumi H, Stone J, Okonkwo DO. Initiating mechanisms involved in the pathobiology of traumatically induced axonal injury and interventions targeted at blunting their progression. Acta Neurochirurgica. Supplement. 73: 15-20. PMID 10494336 DOI: 10.1007/978-3-7091-6391-7_3  0.741
1999 Büki A, Okonkwo DO, Povlishock JT. Postinjury cyclosporin A administration limits axonal damage and disconnection in traumatic brain injury. Journal of Neurotrauma. 16: 511-21. PMID 10391367 DOI: 10.1089/Neu.1999.16.511  0.745
1999 Okonkwo DO, Büki A, Siman R, Povlishock JT. Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury. Neuroreport. 10: 353-8. PMID 10203334 DOI: 10.1097/00001756-199902050-00026  0.726
1999 Okonkwo DO, Povlishock JT. An intrathecal bolus of cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 19: 443-51. PMID 10197514 DOI: 10.1097/00004647-199904000-00010  0.739
1998 Okonkwo DO, Pettus EH, Moroi J, Povlishock JT. Alteration of the neurofilament sidearm and its relation to neurofilament compaction occurring with traumatic axonal injury. Brain Research. 784: 1-6. PMID 9518527 DOI: 10.1016/S0006-8993(97)01075-5  0.703
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