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Michael L Nickels, Ph.D. - Publications

Affiliations: 
2002-2007 Chemistry University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
 2008-2019 Radiology and Radiological Sciences Vanderbilt University School of Medicine, Nashville, TN, United States 
 2019- Mallinckrodt Institute of Radiology Washington University School of medicine in Saint Louis 
Area:
steroid hormones, Radiochemistry, Chemistry, PET
Website:
https://www.mir.wustl.edu/research/research-support-facilities/cyclotron-facility/our-staff

23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zhang X, Liu F, Payne AC, Nickels ML, Bellan LM, Manning HC. High-Yielding Radiosynthesis of [Ga]Ga-PSMA-11 Using a Low-Cost Microfluidic Device. Molecular Imaging and Biology. PMID 32632739 DOI: 10.1007/S11307-020-01515-7  0.315
2020 Buck JR, Saleh S, Claus T, Lovly C, Hight MR, Nickels ML, Noor Tantawy M, Charles Manning H. N-[F]-Fluoroacetylcrizotinib: A potentially potent and selective PET tracer for molecular imaging of non-small cell lung cancer. Bioorganic & Medicinal Chemistry Letters. 30: 127257. PMID 32631505 DOI: 10.1016/J.Bmcl.2020.127257  0.426
2019 Knapp KA, Nickels ML, Manning HC. The Current Role of Microfluidics in Radiofluorination Chemistry. Molecular Imaging and Biology. PMID 31485889 DOI: 10.1007/S11307-019-01414-6  0.348
2019 Uddin MJ, Wilson AJ, Crews BC, Malerba P, Uddin MI, Kingsley PJ, Ghebreselasie K, Daniel CK, Nickels ML, Tantawy MN, Jashim E, Manning HC, Khabele D, Marnett LJ. Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX-1 in Ovarian Cancer. Acs Omega. 4: 9251-9261. PMID 31172046 DOI: 10.1021/acsomega.9b01093  0.343
2018 Tang D, Li J, Nickels ML, Huang G, Cohen AS, Manning HC. Preclinical Evaluation of a Novel TSPO PET Ligand 2-(7-Butyl-2-(4-(2-[F]Fluoroethoxy)phenyl)-5-Methylpyrazolo[1,5-a]Pyrimidin-3-yl)-N,N-Diethylacetamide (F-VUIIS1018A) to Image Glioma. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 29869061 DOI: 10.1007/S11307-018-1198-7  0.441
2018 Zhang X, Liu F, Knapp KA, Nickels ML, Manning HC, Bellan LM. A simple microfluidic platform for rapid and efficient production of the radiotracer [F]fallypride. Lab On a Chip. PMID 29658049 DOI: 10.1039/C8Lc00167G  0.414
2017 Li J, Smith JA, Dawson ES, Fu A, Nickels M, Schulte ML, Manning HC. An Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening. Bioconjugate Chemistry. PMID 28156095 DOI: 10.1021/Acs.Bioconjchem.6B00711  0.349
2016 Tang D, Li J, Buck JR, Tantawy MN, Xia Y, Harp JM, Nickels ML, Meiler J, Manning HC. Evaluation of TSPO PET Ligands [(18)F]VUIIS1009A and [(18)F]VUIIS1009B: Tracers for Cancer Imaging. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 27853987 DOI: 10.1007/S11307-016-1027-9  0.435
2016 Kavanaugh G, Williams J, Morris AS, Nickels ML, Walker R, Koglin N, Stephens AW, Washington MK, Geevarghese SK, Liu Q, Ayers D, Shyr Y, Manning HC. Utility of [(18)F]FSPG PET to Image Hepatocellular Carcinoma: First Clinical Evaluation in a US Population. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 27677886 DOI: 10.1007/S11307-016-1007-0  0.352
2016 Li J, Schulte ML, Nickels ML, Manning HC. New structure-activity relationships of N-acetamide substituted pyrazolopyrimidines as pharmacological ligands of TSPO. Bioorganic & Medicinal Chemistry Letters. PMID 27353534 DOI: 10.1016/J.Bmcl.2016.06.041  0.305
2015 Hassanein M, Hight MR, Buck JR, Tantawy MN, Nickels ML, Hoeksema MD, Harris BK, Boyd K, Massion PP, Manning HC. Preclinical Evaluation of 4-[(18)F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung Cancer. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 25971659 DOI: 10.1007/S11307-015-0862-4  0.36
2015 Felix DD, Gore JC, Yankeelov TE, Peterson TE, Barnes S, Whisenant J, Weis J, Shoukouhi S, Virostko J, Nickels M, McIntyre JO, Sanders M, Abramson V, Tantawy MN. Detection of breast cancer microcalcification using (99m)Tc-MDP SPECT or Osteosense 750EX FMT imaging. Nuclear Medicine and Biology. 42: 269-73. PMID 25533764 DOI: 10.1016/J.Nucmedbio.2014.11.010  0.328
2015 Cheung YY, Nickels ML, McKinley ET, Buck JR, Manning HC. High-yielding, automated production of 3'-deoxy-3'-[(18)F]fluorothymidine using a modified Bioscan Coincidence FDG reaction module. Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine. 97: 47-51. PMID 25531913 DOI: 10.1016/J.Apradiso.2014.11.011  0.403
2014 Cheung YY, Nickels ML, Tang D, Buck JR, Manning HC. Facile synthesis of SSR180575 and discovery of 7-chloro-N,N,5-trimethyl-4-oxo-3(6-[(18)F]fluoropyridin-2-yl)-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, a potent pyridazinoindole ligand for PET imaging of TSPO in cancer. Bioorganic & Medicinal Chemistry Letters. 24: 4466-71. PMID 25172419 DOI: 10.1016/J.Bmcl.2014.07.091  0.402
2014 Tang D, Nickels ML, Tantawy MN, Buck JR, Manning HC. Preclinical imaging evaluation of novel TSPO-PET ligand 2-(5,7-Diethyl-2-(4-(2-[(18)F]fluoroethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide ([ (18)F]VUIIS1008) in glioma. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 16: 813-20. PMID 24845529 DOI: 10.1007/S11307-014-0743-2  0.429
2014 Perrone MG, Malerba P, Uddin MJ, Vitale P, Panella A, Crews BC, Daniel CK, Ghebreselasie K, Nickels M, Tantawy MN, Manning HC, Marnett LJ, Scilimati A. PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation. European Journal of Medicinal Chemistry. 80: 562-8. PMID 24832612 DOI: 10.1016/J.Ejmech.2014.04.074  0.333
2014 Hight MR, Cheung YY, Nickels ML, Dawson ES, Zhao P, Saleh S, Buck JR, Tang D, Washington MK, Coffey RJ, Manning HC. A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 2126-35. PMID 24573549 DOI: 10.1158/1078-0432.Ccr-13-2444  0.344
2014 Cheung Y, Buck JR, Nickels ML, Tang D, Manning HC. Abstract 110: Preclinical evaluation of 7-chloro-N,N,5-trimethyl-4-oxo-3(6-[18F]fluoropyridin-2-yl)-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide: A novel pyridazinoindole ligand for PET imaging of TSPO in cancer Cancer Research. 74: 110-110. DOI: 10.1158/1538-7445.Am2014-110  0.447
2013 Tang D, McKinley ET, Hight MR, Uddin MI, Harp JM, Fu A, Nickels ML, Buck JR, Manning HC. Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging. Journal of Medicinal Chemistry. 56: 3429-33. PMID 23521048 DOI: 10.1021/Jm4001874  0.442
2012 Nolting DD, Nickels M, Tantawy MN, Yu JY, Xie J, Peterson TE, Crews BC, Marnett L, Gore JC, Pham W. Convergent synthesis and evaluation of (18)F-labeled azulenic COX2 probes for cancer imaging. Frontiers in Oncology. 2: 207. PMID 23316477 DOI: 10.3389/Fonc.2012.00207  0.461
2012 Tang D, Hight MR, McKinley ET, Fu A, Buck JR, Smith RA, Tantawy MN, Peterson TE, Colvin DC, Ansari MS, Nickels M, Manning HC. Quantitative preclinical imaging of TSPO expression in glioma using N,N-diethyl-2-(2-(4-(2-18F-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 53: 287-94. PMID 22251555 DOI: 10.2967/Jnumed.111.095653  0.418
2011 Miller CP, Shomali M, Lyttle CR, O'Dea LS, Herendeen H, Gallacher K, Paquin D, Compton DR, Sahoo B, Kerrigan SA, Burge MS, Nickels M, Green JL, Katzenellenbogen JA, Tchesnokov A, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. Acs Medicinal Chemistry Letters. 2: 124-9. PMID 24900290 DOI: 10.1021/Ml1002508  0.513
2009 Nolting DD, Nickels M, Price R, Gore JC, Pham W. Synthesis of bicyclo[5.3.0]azulene derivatives. Nature Protocols. 4: 1113-7. PMID 19617883 DOI: 10.1038/Nprot.2009.99  0.457
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