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Jarrod B. French, Ph.D. - Publications

Affiliations: 
2010 Cornell University, Ithaca, NY, United States 
Area:
structure and function of proteins using X-ray crystallography
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Belfon KKJ, Sharma N, Zigweid R, Bolejack M, Davies D, Edwards TE, Myler PJ, French JB. Structure-Guided Discovery of N-CAIR Mutase Inhibitors. Biochemistry. 62: 2587-2596. PMID 37552766 DOI: 10.1021/acs.biochem.2c00705  0.311
2023 Kim-Holzapfel DM, Dey R, Richardson BC, Arachchige D, Reddy K, De Vitto H, Bhandari J, French JB. Human Uridine 5'-Monophosphate Synthase Stores Metabolic Potential in Inactive Biomolecular Condensates. The Journal of Biological Chemistry. 102949. PMID 36708921 DOI: 10.1016/j.jbc.2023.102949  0.307
2022 Richardson BC, Shek R, Van Voorhis WC, French JB. Structure of Klebsiella pneumoniae adenosine monophosphate nucleosidase. Plos One. 17: e0275023. PMID 36264993 DOI: 10.1371/journal.pone.0275023  0.359
2021 Chitrakar I, Ahmed SF, Torelli AT, French JB. Structure of the E. coli agmatinase, SPEB. Plos One. 16: e0248991. PMID 33857156 DOI: 10.1371/journal.pone.0248991  0.312
2020 Chitrakar I, Iuliano JN, He Y, Woroniecka H, Tolentino Collado J, Wint J, Walker SG, Tonge PJ, French JB. Structural basis for the regulation of biofilm formation and iron uptake in A. baumannii by the blue-light using photoreceptor, BlsA. Acs Infectious Diseases. PMID 32926768 DOI: 10.1021/Acsinfecdis.0C00156  0.352
2020 Iuliano JN, Tolentino Collado J, Gil AA, Ravindran PT, Lukacs A, Shin S, Woroniecka HA, Adamczyk K, Aramini JM, Edupuganti UR, Hall CR, Greetham GM, Sazanovich IV, Clark IP, Daryaee T, ... ... French JB, et al. Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix. Acs Chemical Biology. PMID 32880430 DOI: 10.1021/Acschembio.0C00543  0.334
2020 Yin Y, Frank D, Zhou W, Kaur N, French JB, Carpino N. An unexpected 2-histidine phosphoesterase activity of Suppressor of T cell receptor signaling protein-1 contributes to the suppression of cell signaling. The Journal of Biological Chemistry. PMID 32371395 DOI: 10.1074/Jbc.Ra120.013482  0.384
2020 Ahmed SF, Chitrakar I, Torelli AT, French JB. X‐ray Crystal Structure of Agmatinase from Escherichia coli The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03183  0.334
2019 Shek R, Hilaire T, Sim J, French JB. Structural determinants for substrate selectivity in guanine deaminase enzymes of the amidohydrolase superfamily. Biochemistry. PMID 31283204 DOI: 10.2210/Pdb6Oh9/Pdb  0.475
2019 Evans CE, Si Y, Matarlo JS, Yin Y, French JB, Tonge PJ, Tan DS. Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE. Biochemistry. PMID 30912442 DOI: 10.1021/Acs.Biochem.9B00003  0.41
2019 Zhou W, Tsai A, Dattmore DA, Stives DP, Chitrakar I, D'alessandro AM, Patil S, Hicks KA, French JB. Crystal structure of E. coli PRPP synthetase. Bmc Structural Biology. 19: 1. PMID 30646888 DOI: 10.2210/Pdb6Asv/Pdb  0.415
2018 Zhou W, Yin Y, Smith E, Chou J, Shumate J, Scampavia L, Spicer T, Carpino N, French JB. Discovery and Characterization of Two Classes of Selective Inhibitors of the Suppressor of TCR Signaling Family of Proteins. Acs Infectious Diseases. PMID 30485744 DOI: 10.1021/Acsinfecdis.8B00238  0.359
2018 Shek R, French JB. Structural and functional studies of E. coli guanine deaminase Acta Crystallographica Section a Foundations and Advances. 74: a42-a42. DOI: 10.1107/S0108767318099579  0.302
2017 Iuliano JN, Gil AA, Laptenok SP, Hall CR, Tolentino Collado J, Lukacs A, Hag Ahmed SA, Abyad J, Daryaee T, Greetham GM, Sazanovich IV, Illarionov B, Bacher A, Fischer M, Towrie M, ... French JB, et al. Variation in LOV Photoreceptor Activation Dynamics Probed by Time Resolved Infrared Spectroscopy. Biochemistry. PMID 29239168 DOI: 10.1021/Acs.Biochem.7B01040  0.338
2017 Shek R, Dattmore DA, Stives DP, Jackson AL, Chatfield CH, Hicks KA, French JB. Structural and Functional Basis for Targeting Campylobacter jejuni Agmatine Deiminase To Overcome Antibiotic Resistance. Biochemistry. 56: 6734-6742. PMID 29190068 DOI: 10.1021/Acs.Biochem.7B00982  0.428
2017 Gil AA, Laptenok SP, Iuliano JN, Lukacs A, Verma A, Hall CR, Yoon E, Brust R, Greetham GM, Towrie M, French JB, Meech SR, Tonge PJ. Photoactivation of the BLUF protein PixD Probed by the Site-Specific Incorporation of Fluorotyrosine Residues. Journal of the American Chemical Society. PMID 28876066 DOI: 10.1021/Jacs.7B07849  0.326
2017 Zhou W, Yin Y, Weinheimer AS, Kaur N, Carpino N, French JB. Structural and functional characterization of the histidine phosphatase domains of human Sts-1 and Sts-2. Biochemistry. PMID 28759203 DOI: 10.1021/Acs.Biochem.7B00638  0.39
2017 Chitrakar I, Kim-Holzapfel DM, Zhou W, French JB. Higher Order Structures in Purine and Pyrimidine Metabolism. Journal of Structural Biology. PMID 28115257 DOI: 10.1016/J.Jsb.2017.01.003  0.416
2017 Gil AA, Laptenok SP, French JB, Iuliano JN, Lukacs A, Hall CR, Sazanovich IV, Greetham GM, Bacher A, Illarionov B, Fischer M, Tonge PJ, Meech SR. Femtosecond To Millisecond Dynamics Of Light Induced Allostery In The Avena Sativa Lov Domain. The Journal of Physical Chemistry. B. PMID 28068090 DOI: 10.1021/Acs.Jpcb.7B00088  0.397
2016 French JB, Jones SA, Deng H, Pedley AM, Kim D, Chan CY, Hu H, Pugh RJ, Zhao H, Zhang Y, Huang TJ, Fang Y, Zhuang X, Benkovic SJ. Spatial colocalization and functional link of purinosomes with mitochondria. Science (New York, N.Y.). 351: 733-7. PMID 26912862 DOI: 10.1126/Science.Aac6054  0.353
2015 Gil AA, Haigney AL, Laptenok SP, Brust RJ, Lukacs A, Iuliano J, Jeng J, Melief E, Zhao RK, Yoon E, Clark IP, Towrie M, Greetham GM, Ng A, Truglio JJ, ... French JB, et al. The Mechanism of the AppABLUF Photocycle Probed by Site-Specific Incorporation of Fluorotyrosine Residues: The Effect of the Y21 pKa on the Forward and Reverse Ground State Reactions. Journal of the American Chemical Society. PMID 26708408 DOI: 10.1021/Jacs.5B11115  0.317
2015 Matarlo JS, Evans CE, Sharma I, Lavaud LJ, Ngo SC, Shek R, Rajashankar KR, French JB, Tan DS, Tonge PJ. Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents. Biochemistry. PMID 26394156 DOI: 10.1021/Acs.Biochem.5B00966  0.401
2015 Chan CY, Zhao H, Pugh RJ, Pedley AM, French J, Jones SA, Zhuang X, Jinnah H, Huang TJ, Benkovic SJ. Purinosome formation as a function of the cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 112: 1368-73. PMID 25605889 DOI: 10.1073/Pnas.1423009112  0.306
2015 Zhao H, Chiaro CR, Zhang L, Smith PB, Chan CY, Pedley AM, Pugh RJ, French JB, Patterson AD, Benkovic SJ. Quantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis. The Journal of Biological Chemistry. 290: 6705-13. PMID 25605736 DOI: 10.1074/Jbc.M114.628701  0.36
2014 Liu CT, Layfield JP, Stewart RJ, French JB, Hanoian P, Asbury JB, Hammes-Schiffer S, Benkovic SJ. Probing the electrostatics of active site microenvironments along the catalytic cycle for Escherichia coli dihydrofolate reductase. Journal of the American Chemical Society. 136: 10349-60. PMID 24977791 DOI: 10.1021/Ja5038947  0.384
2013 Fang Y, French J, Zhao H, Benkovic S. G-protein-coupled receptor regulation of de novo purine biosynthesis: a novel druggable mechanism. Biotechnology & Genetic Engineering Reviews. 29: 31-48. PMID 24568251 DOI: 10.1080/02648725.2013.801237  0.348
2013 Liu CT, Hanoian P, French JB, Pringle TH, Hammes-Schiffer S, Benkovic SJ. Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans. Proceedings of the National Academy of Sciences of the United States of America. 110: 10159-64. PMID 23733948 DOI: 10.1073/Pnas.1307130110  0.398
2013 Zhao H, French JB, Fang Y, Benkovic SJ. The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans. Chemical Communications (Cambridge, England). 49: 4444-52. PMID 23575936 DOI: 10.1039/C3Cc41437J  0.323
2012 Deng Y, Gam J, French JB, Zhao H, An S, Benkovic SJ. Mapping protein-protein proximity in the purinosome. The Journal of Biological Chemistry. 287: 36201-7. PMID 22955281 DOI: 10.1074/Jbc.M112.407056  0.375
2011 French JB, Begley TP, Ealick SE. Structure of trifunctional THI20 from yeast. Acta Crystallographica. Section D, Biological Crystallography. 67: 784-91. PMID 21904031 DOI: 10.1107/S0907444911024814  0.587
2011 French JB, Ealick SE. Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae. Acta Crystallographica. Section D, Biological Crystallography. 67: 671-7. PMID 21795808 DOI: 10.1107/S090744491101746X  0.607
2011 French JB, Neau DB, Ealick SE. Characterization of the structure and function of Klebsiella pneumoniae allantoin racemase. Journal of Molecular Biology. 410: 447-60. PMID 21616082 DOI: 10.1016/J.Jmb.2011.05.016  0.613
2011 French JB, Yates PA, Soysa DR, Boitz JM, Carter NS, Chang B, Ullman B, Ealick SE. The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization. The Journal of Biological Chemistry. 286: 20930-41. PMID 21507942 DOI: 10.1074/Jbc.M111.228213  0.603
2010 French JB, Cen Y, Vrablik TL, Xu P, Allen E, Hanna-Rose W, Sauve AA. Characterization of nicotinamidases: steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism. Biochemistry. 49: 10421-39. PMID 20979384 DOI: 10.1021/Bi1012518  0.431
2010 French JB, Cen Y, Sauve AA, Ealick SE. High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes . Biochemistry. 49: 8803-12. PMID 20853856 DOI: 10.1021/Bi1012436  0.62
2010 French JB, Ealick SE. Structural and mechanistic studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. The Journal of Biological Chemistry. 285: 35446-54. PMID 20826786 DOI: 10.1074/Jbc.M110.156034  0.609
2010 French JB, Ealick SE. Biochemical and structural characterization of a ureidoglycine aminotransferase in the Klebsiella pneumoniae uric acid catabolic pathway. Biochemistry. 49: 5975-7. PMID 20565126 DOI: 10.1021/Bi1006755  0.545
2008 French JB, Cen Y, Sauve AA. Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase. Biochemistry. 47: 10227-39. PMID 18729382 DOI: 10.1021/Bi800767T  0.354
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