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Fengtian Xue, Ph.D. - Publications

Affiliations: 
2007 Brown University, Providence, RI 
Area:
molecular recognition in biological systems
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Liang D, Li L, Lynch C, Mackowiak B, Hedrich WD, Ai Y, Yin Y, Heyward S, Xia M, Wang H, Xue F. Human constitutive androstane receptor agonist DL5016: A novel sensitizer for cyclophosphamide-based chemotherapies. European Journal of Medicinal Chemistry. 179: 84-99. PMID 31247375 DOI: 10.1016/J.Ejmech.2019.06.031  0.314
2019 Zhao J, Liang D, Robinson E, Xue F. The effects of novel heme oxygenase inhibitors on the growth of Pseudomonas aeruginosa. Microbial Pathogenesis. PMID 30716393 DOI: 10.1016/J.Micpath.2019.01.047  0.326
2018 Liang D, Robinson E, Hom K, Yu W, Nguyen N, Li Y, Zong Q, Wilks A, Xue F. Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme oxygenase (pa-HemO). Bioorganic & Medicinal Chemistry Letters. PMID 29459206 DOI: 10.1016/J.Bmcl.2018.02.027  0.331
2017 Liang D, Yu W, Nguyen N, Deschamps JR, Imler GH, Li Y, MacKerell A, Jiang C, Xue F. Iodobenzene-Catalyzed Synthesis of Phenanthridinones via Oxidative C-H Amidation. The Journal of Organic Chemistry. PMID 28245353 DOI: 10.1021/Acs.Joc.7B00106  0.312
2016 Cardenas MG, Oswald E, Yu W, Xue F, MacKerell AD, Melnick AM. The expanding role of the BCL6 oncoprotein as a cancer therapeutic target. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27881582 DOI: 10.1158/1078-0432.Ccr-16-2071  0.335
2016 Cardenas MG, Yu W, Beguelin W, Teater MR, Geng H, Goldstein RL, Oswald E, Hatzi K, Yang SN, Cohen J, Shaknovich R, Vanommeslaeghe K, Cheng H, Liang D, Cho HJ, ... ... Xue F, et al. Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma. The Journal of Clinical Investigation. PMID 27482887 DOI: 10.1172/Jci85795  0.328
2016 Heinzl GA, Huang W, Yu W, Giardina BJ, Zhou Y, MacKerell AD, Wilks A, Xue F. Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa. Journal of Medicinal Chemistry. PMID 27353344 DOI: 10.1021/Acs.Jmedchem.6B00757  0.36
2015 Holden JK, Dejam D, Lewis MC, Huang H, Kang S, Jing Q, Xue F, Silverman RB, Poulos TL. Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase. Biochemistry. 54: 4075-82. PMID 26062720 DOI: 10.1021/Acs.Biochem.5B00431  0.363
2015 Lakkaraju SK, Mbatia H, Hanscom M, Zhao Z, Wu J, Stoica B, MacKerell AD, Faden AI, Xue F. Cyclopropyl-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5. Bioorganic & Medicinal Chemistry Letters. 25: 2275-9. PMID 25937015 DOI: 10.1016/J.Bmcl.2015.04.042  0.336
2015 Li T, He X, Thomas JM, Yang D, Zhong S, Xue F, Smith WW. A novel GTP-binding inhibitor, FX2149, attenuates LRRK2 toxicity in Parkinson's disease models. Plos One. 10: e0122461. PMID 25816252 DOI: 10.1371/Journal.Pone.0122461  0.369
2015 He X, Lakkaraju SK, Hanscom M, Zhao Z, Wu J, Stoica B, MacKerell AD, Faden AI, Xue F. Acyl-2-aminobenzimidazoles: a novel class of neuroprotective agents targeting mGluR5. Bioorganic & Medicinal Chemistry. 23: 2211-20. PMID 25801156 DOI: 10.1016/J.Bmc.2015.02.054  0.339
2015 Holden JK, Kang S, Hollingsworth SA, Li H, Lim N, Chen S, Huang H, Xue F, Tang W, Silverman RB, Poulos TL. Structure-based design of bacterial nitric oxide synthase inhibitors. Journal of Medicinal Chemistry. 58: 994-1004. PMID 25522110 DOI: 10.1021/Jm501723P  0.402
2014 Li T, Yang D, Zhong S, Thomas JM, Xue F, Liu J, Kong L, Voulalas P, Hassan HE, Park JS, MacKerell AD, Smith WW. Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models. Human Molecular Genetics. 23: 6212-22. PMID 24993787 DOI: 10.1093/Hmg/Ddu341  0.338
2013 Hom K, Heinzl GA, Eakanunkul S, Lopes PE, Xue F, MacKerell AD, Wilks A. Small molecule antivirulents targeting the iron-regulated heme oxygenase (HemO) of P. aeruginosa. Journal of Medicinal Chemistry. 56: 2097-109. PMID 23379514 DOI: 10.1021/Jm301819K  0.358
2013 Li H, Xue F, Kraus JM, Ji H, Labby KJ, Mataka J, Delker SL, Martásek P, Roman LJ, Poulos TL, Silverman RB. Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 21: 1333-1343. PMID 23352768 DOI: 10.1016/J.Bmc.2012.12.019  0.416
2013 Nagagarajan S, Xue F, MacKerell AD. Impact of substrate protonation and tautomerization states on interactions with the active site of arginase I. Journal of Chemical Information and Modeling. 53: 452-60. PMID 23327293 DOI: 10.1021/Ci300506Y  0.329
2012 Labby KJ, Xue F, Kraus JM, Ji H, Mataka J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Intramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 20: 2435-2443. PMID 22370337 DOI: 10.1016/J.Bmc.2012.01.037  0.341
2011 Xue F, Kraus JM, Labby KJ, Ji H, Mataka J, Xia G, Li H, Delker SL, Roman LJ, Martásek P, Poulos TL, Silverman RB. Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 6399-6403. PMID 21809851 DOI: 10.1021/Jm200411J  0.375
2011 Xue F, Fang J, Delker SL, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 2039-2048. PMID 21410186 DOI: 10.1021/Jm101071N  0.411
2011 Xue F, Seto CT. Kinetic delay of cyclization/elimination-coupled enzyme assays: analysis and solution. Bioorganic & Medicinal Chemistry Letters. 21: 1069-71. PMID 21211970 DOI: 10.1016/J.Bmcl.2010.09.104  0.587
2010 Delker SL, Xue F, Li H, Jamal J, Silverman RB, Poulos TL. Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase Biochemistry. 49: 10803-10810. PMID 21138269 DOI: 10.1021/Bi1013479  0.401
2010 Xue F, Li H, Delker SL, Fang J, Martásek P, Roman LJ, Poulos TL, Silverman RB. Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase Journal of the American Chemical Society. 132: 14229-14238. PMID 20843082 DOI: 10.1021/Ja106175Q  0.379
2010 Xue F, Li H, Fang J, Roman LJ, Martásek P, Poulos TL, Silverman RB. Peripheral but crucial: A hydrophobic pocket (Tyr706, Leu 337, and Met336) for potent and selective inhibition of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry Letters. 20: 6258-6261. PMID 20833542 DOI: 10.1016/J.Bmcl.2010.08.096  0.407
2010 Xue F, Huang J, Ji H, Fang J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 18: 6526-6537. PMID 20673724 DOI: 10.1016/J.Bmc.2010.06.074  0.389
2010 Xue F, Seto CT. Fluorogenic peptide substrates for serine and threonine phosphatases. Organic Letters. 12: 1936-9. PMID 20359238 DOI: 10.1021/Ol1003065  0.612
2010 Delker SL, Ji H, Li H, Jamal J, Fang J, Xue F, Silverman RB, Poulos TL. Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model Journal of the American Chemical Society. 132: 5437-5442. PMID 20337441 DOI: 10.1021/Ja910228A  0.414
2010 Delker SL, Ji H, Li H, Jamal J, Fang J, Xue F, Silverman RB, Poulos TL. Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model Journal of the American Chemical Society. 132: 14688-14688. DOI: 10.1021/Ja107808U  0.301
2009 Xue F, Gu W, Silverman RB. Concise route to the chiral pyrrolidine core of selective inhibitors of neuronal nitric oxide Organic Letters. 11: 5194-5197. PMID 19860389 DOI: 10.1021/Ol902109T  0.313
2009 Fang J, Ji H, Lawton GR, Xue F, Roman LJ, Silverman RB. L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors Journal of Medicinal Chemistry. 52: 4533-4537. PMID 19537690 DOI: 10.1021/Jm900380J  0.326
2009 Lawton GR, Ralay Ranaivo H, Chico LK, Ji H, Xue F, Martásek P, Roman LJ, Watterson DM, Silverman RB. Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability. Bioorganic & Medicinal Chemistry. 17: 2371-80. PMID 19268602 DOI: 10.1016/J.Bmc.2009.02.017  0.364
2009 Xue F, Seto CT. Macrocyclic inhibitors for the serine protease plasmin. Journal of Enzyme Inhibition and Medicinal Chemistry. 24: 779-94. PMID 18825554 DOI: 10.1080/14756360802364401  0.655
2007 Hassanein M, Xue F, Seto CT, Mason RW. Development of a specific inhibitor for the placental protease, cathepsin P. Archives of Biochemistry and Biophysics. 464: 288-94. PMID 17531191 DOI: 10.1016/J.Abb.2007.04.019  0.616
2006 Xue F, Seto CT. Structure-activity studies of cyclic ketone inhibitors of the serine protease plasmin: design, synthesis, and biological activity. Bioorganic & Medicinal Chemistry. 14: 8467-87. PMID 16971130 DOI: 10.1016/J.Bmc.2006.08.040  0.663
2005 Xue F, Seto CT. Selective inhibitors of the serine protease plasmin: probing the S3 and S3' subsites using a combinatorial library. Journal of Medicinal Chemistry. 48: 6908-17. PMID 16250649 DOI: 10.1021/Jm050488K  0.649
2005 Xue F, Seto CT. A comparison of cyclohexanone and tetrahydro-4H-thiopyran-4-one 1,1-dioxide as pharmacophores for the design of peptide-based inhibitors of the serine protease plasmin. The Journal of Organic Chemistry. 70: 8309-21. PMID 16209572 DOI: 10.1021/Jo0508954  0.653
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