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Karen M. Wagner, Ph.D. - Publications

Affiliations: 
2012 Pharmacology and Toxicology University of California, Davis, Davis, CA 
Area:
Pesticide Biotechnology
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49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wang W, Wang Y, Wagner KM, Lee RD, Hwang SH, Morisseau C, Wulff H, Hammock BD. Aflatoxin B Increases Soluble Epoxide Hydrolase in the Brain and Induces Neuroinflammation and Dopaminergic Neurotoxicity. International Journal of Molecular Sciences. 24. PMID 37373086 DOI: 10.3390/ijms24129938  0.307
2023 Wang W, Wagner KM, Wang Y, Singh N, Yang J, He Q, Morisseau C, Hammock BD. Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon. International Journal of Molecular Sciences. 24. PMID 36901999 DOI: 10.3390/ijms24054570  0.331
2023 Takeshita AA, Hammock BD, Wagner KM. Soluble epoxide hydrolase inhibition alleviates chemotherapy induced neuropathic pain. Frontiers in Pain Research (Lausanne, Switzerland). 3: 1100524. PMID 36700145 DOI: 10.3389/fpain.2022.1100524  0.516
2023 Atone J, Wagner K, Koike S, Yang J, Hwang SH, Hammock BD. Inhibition of Soluble Epoxide Hydrolase Reduces Paraquat Neurotoxicity in Rodents. Environmental Toxicology and Pharmacology. 104070. PMID 36682504 DOI: 10.1016/j.etap.2023.104070  0.391
2022 Nguyen PT, Nguyen HM, Wagner KM, Stewart R, Singh V, Thapa P, Chen YJ, Lillya MW, Ton AT, Kondo R, Ghetti A, Pennington MW, Hammock B, Griffith TN, Sack JT, et al. Computational design of peptides to target Na1.7 channel with high potency and selectivity for the treatment of pain. Elife. 11. PMID 36576241 DOI: 10.7554/eLife.81727  0.385
2022 Wang W, Wang Y, Yang J, Wagner KM, Hwang SH, Cheng J, Singh N, Edwards P, Morisseau C, Zhang G, Panigrahy D, Hammock BD. Aflatoxin B exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-mediated manner. Ecotoxicology and Environmental Safety. 249: 114417. PMID 36525946 DOI: 10.1016/j.ecoenv.2022.114417  0.352
2022 Zhang C, Li W, Li X, Wan D, Mack S, Zhang J, Wagner K, Wang C, Tan B, Chen J, Wu CW, Tsuji K, Takeuchi M, Chen Z, Hammock BD, et al. Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor. Plos One. 17: e0266608. PMID 35443010 DOI: 10.1371/journal.pone.0266608  0.34
2021 Wagner KM, Yang J, Morisseau C, Hammock BD. Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation. Frontiers in Pharmacology. 12: 778470. PMID 34975481 DOI: 10.3389/fphar.2021.778470  0.34
2021 McReynolds CB, Yang J, Guedes A, Morisseau C, Garcia R, Knych H, Tearney C, Hamamoto B, Hwang SH, Wagner K, Hammock BD. Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development. Molecules (Basel, Switzerland). 26. PMID 34443621 DOI: 10.3390/molecules26165034  0.409
2021 Singh N, Barnych B, Wagner KM, Wan D, Morisseau C, Hammock BD. Adrenic Acid-Derived Epoxy Fatty Acids Are Naturally Occurring Lipids and Their Methyl Ester Prodrug Reduces Endoplasmic Reticulum Stress and Inflammatory Pain. Acs Omega. 6: 7165-7174. PMID 33748630 DOI: 10.1021/acsomega.1c00241  0.466
2021 Hammock BD, McReynolds CB, Wagner K, Buckpitt A, Cortes-Puch I, Croston G, Lee KSS, Yang J, Schmidt WK, Hwang SH. Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative. Journal of Medicinal Chemistry. PMID 33550801 DOI: 10.1021/acs.jmedchem.0c01886  0.538
2021 Wang Y, Wagner KM, Morisseau C, Hammock BD. Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Evidence. Journal of Pain Research. 14: 61-72. PMID 33488116 DOI: 10.2147/JPR.S241893  0.549
2020 Singh N, Barnych B, Morisseau C, Wagner KM, Wan D, Takeshita A, Pham H, Xu T, Dandekar A, Liu JY, Hammock BD. -Benzyl-linoleamide, a Constituent of (Maca), Is an Orally Bioavailable Soluble Epoxide Hydrolase Inhibitor That Alleviates Inflammatory Pain. Journal of Natural Products. PMID 33320645 DOI: 10.1021/acs.jnatprod.0c00938  0.475
2020 Lee KSS, Ng JC, Yang J, Hwang SH, Morisseau C, Wagner K, Hammock BD. Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain. Bioorganic & Medicinal Chemistry. 28: 115735. PMID 33007552 DOI: 10.1016/J.Bmc.2020.115735  0.577
2020 McReynolds C, Morisseau C, Wagner K, Hammock B. Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation. Advances in Experimental Medicine and Biology. 1274: 71-99. PMID 32894508 DOI: 10.1007/978-3-030-50621-6_5  0.539
2020 Wagner KM, Gomes A, McReynolds CB, Hammock BD. Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 32875445 DOI: 10.1007/S13311-020-00916-4  0.597
2020 Li D, Cui Y, Morisseau C, Wagner KM, Cho YS, Hammock BD. Development of Highly Sensitive ELISA for Mouse Soluble Epoxide Hydrolase Detection by Combining a Polyclonal Capture Antibody with a Nanobody Tracer. Analytical Chemistry. PMID 32786492 DOI: 10.1021/Acs.Analchem.0C01511  0.423
2020 YANG J, Wagner K, Wan D, Hwang S, McReynolds CB, Hammock BD. Pharmacokinetics of a potent soluble epoxide hydrolase inhibitor in three formulations The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.09963  0.484
2019 Wagner KM, Atone J, Hammock BD. Soluble epoxide hydrolase inhibitor mediated analgesia lacks tolerance in rat models. Brain Research. 1728: 146573. PMID 31790682 DOI: 10.1016/J.Brainres.2019.146573  0.581
2019 Atone J, Wagner K, Hashimoto K, Hammock B. Prostaglandins and Other Lipid Mediators Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases. Prostaglandins & Other Lipid Mediators. 106385. PMID 31698143 DOI: 10.1016/J.Prostaglandins.2019.106385  0.488
2019 Lee KSS, Yang J, Niu J, Ng CJ, Wagner KM, Dong H, Kodani SD, Wan D, Morisseau C, Hammock BD. Drug-Target Residence Time Affects Target Occupancy through Multiple Pathways. Acs Central Science. 5: 1614-1624. PMID 31572788 DOI: 10.1021/Acscentsci.9B00770  0.415
2019 Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, Morisseau C, Angioni C, Geisslinger G, Kahnt AS, Kaiser A, Proschak A, Steinhilber D, Pogoryelov D, Wagner K, et al. Computer-Aided Selective Optimization of Side Activities of Talinolol. Acs Medicinal Chemistry Letters. 10: 899-903. PMID 31223445 DOI: 10.2210/Pdb6Hgv/Pdb  0.494
2019 McReynolds CB, Hwang SH, Yang J, Wan D, Wagner K, Morisseau C, Li D, Schmidt WK, Hammock BD. Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis. Frontiers in Pharmacology. 10: 533. PMID 31214021 DOI: 10.3389/Fphar.2019.00533  0.609
2019 Wan D, Yang J, McReynolds CB, Barnych B, Wagner KM, Morisseau C, Hwang SH, Sun J, Blöcher R, Hammock BD. and Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea. Frontiers in Pharmacology. 10: 464. PMID 31143115 DOI: 10.3389/Fphar.2019.00464  0.414
2018 Hiesinger K, Wagner KM, Hammock BD, Proschak E, Hwang SH. Development of Multitarget Agents Possessing Soluble Epoxide Hydrolase Inhibitory Activity. Prostaglandins & Other Lipid Mediators. PMID 30593866 DOI: 10.1016/J.Prostaglandins.2018.12.003  0.483
2018 Kodani SD, Wan D, Wagner KM, Hwang SH, Morisseau C, Hammock BD. Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors. Acs Omega. 3: 14076-14086. PMID 30411058 DOI: 10.1021/acsomega.8b01625  0.522
2018 Lee KSS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, et al. Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy. Journal of Medicinal Chemistry. PMID 29701466 DOI: 10.1021/Acs.Jmedchem.8B00582  0.644
2018 Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD. Orally available soluble epoxide hydrolase/phosphodiesterase 4 dual inhibitor treats inflammatory pain. Journal of Medicinal Chemistry. PMID 29614224 DOI: 10.1021/Acs.Jmedchem.7B01804  0.597
2017 Wagner KM, McReynolds CB, Schmidt WK, Hammock BD. Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases. Pharmacology & Therapeutics. PMID 28642117 DOI: 10.1016/J.Pharmthera.2017.06.006  0.611
2017 Fiala M, Kooij G, Wagner K, Hammock B, Pellegrini M. Modulation of innate immunity of patients with Alzheimer's disease by omega-3 fatty acids. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28420693 DOI: 10.1096/Fj.201700065R  0.406
2017 Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behavioural Brain Research. PMID 28259677 DOI: 10.1016/J.Bbr.2017.02.048  0.541
2016 Hwang SH, Wagner K, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee KS, Hammock BD. Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids. Bioorganic & Medicinal Chemistry Letters. PMID 28025003 DOI: 10.1016/J.Bmcl.2016.12.002  0.52
2016 Wagner K, Lee KS, Yang J, Hammock BD. Epoxy fatty acids mediate analgesia in murine diabetic neuropathy. European Journal of Pain (London, England). PMID 27634339 DOI: 10.1002/Ejp.939  0.56
2016 Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang JC, Yang C, Yao W, Dong C, Han M, Hammock BD, Hashimoto K. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976569 DOI: 10.1073/Pnas.1601532113  0.39
2015 Sasso O, Wagner K, Morisseau C, Inceoglu B, Hammock BD, Piomelli D. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 97: 7-15. PMID 25882247 DOI: 10.1016/J.Phrs.2015.04.001  0.643
2014 Wagner K, Vito S, Inceoglu B, Hammock BD. The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling. Prostaglandins & Other Lipid Mediators. 113: 2-12. PMID 25240260 DOI: 10.1016/J.Prostaglandins.2014.09.001  0.588
2014 Lee KS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, et al. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. Journal of Medicinal Chemistry. 57: 7016-30. PMID 25079952 DOI: 10.1021/Jm500694P  0.709
2014 Wagner K, Yang J, Inceoglu B, Hammock BD. Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. The Journal of Pain : Official Journal of the American Pain Society. 15: 907-14. PMID 24924124 DOI: 10.1016/J.Jpain.2014.05.008  0.596
2014 Hammock BD, Wagner K, Inceoglu B. The soluble epoxide hydrolase as a pharmaceutical target for pain management. Pain Management. 1: 383-6. PMID 24645702 DOI: 10.2217/Pmt.11.47  0.618
2013 Inceoglu B, Zolkowska D, Yoo HJ, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD. Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures. Plos One. 8: e80922. PMID 24349022 DOI: 10.1371/Journal.Pone.0080922  0.46
2013 Hwang SH, Wecksler AT, Wagner K, Hammock BD. Rationally designed multitarget agents against inflammation and pain. Current Medicinal Chemistry. 20: 1783-99. PMID 23410172 DOI: 10.2174/0929867311320130013  0.58
2013 Wagner K, Inceoglu B, Dong H, Yang J, Hwang SH, Jones P, Morisseau C, Hammock BD. Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. European Journal of Pharmacology. 700: 93-101. PMID 23276668 DOI: 10.1016/J.Ejphar.2012.12.015  0.628
2012 Inceoglu B, Wagner KM, Yang J, Bettaieb A, Schebb NH, Hwang SH, Morisseau C, Haj FG, Hammock BD. Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes. Proceedings of the National Academy of Sciences of the United States of America. 109: 11390-5. PMID 22733772 DOI: 10.1073/Pnas.1208708109  0.583
2011 Wagner K, Inceoglu B, Hammock BD. Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception Prostaglandins and Other Lipid Mediators. 96: 76-83. PMID 21854866 DOI: 10.1016/J.Prostaglandins.2011.08.001  0.618
2011 Schebb NH, Inceoglu B, Rose T, Wagner K, Hammock BD. Development of an ultra fast online-solid phase extraction (SPE) liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) based approach for the determination of drugs in pharmacokinetic studies. Analytical Methods : Advancing Methods and Applications. 3: 420-428. PMID 21660124 DOI: 10.1039/C0Ay00714E  0.37
2011 Hwang SH, Wagner KM, Morisseau C, Liu JY, Dong H, Wecksler AT, Hammock BD. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. Journal of Medicinal Chemistry. 54: 3037-50. PMID 21434686 DOI: 10.1021/Jm2001376  0.522
2011 Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proceedings of the National Academy of Sciences of the United States of America. 108: 5093-7. PMID 21383170 DOI: 10.1073/Pnas.1101073108  0.729
2011 Wagner K, Inceoglu B, Gill SS, Hammock BD. Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction. Journal of Agricultural and Food Chemistry. 59: 2816-24. PMID 20958046 DOI: 10.1021/Jf102559Q  0.64
2008 Inceoglu B, Jinks SL, Ulu A, Hegedus CM, Georgi K, Schmelzer KR, Wagner K, Jones PD, Morisseau C, Hammock BD. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proceedings of the National Academy of Sciences of the United States of America. 105: 18901-6. PMID 19028872 DOI: 10.1073/Pnas.0809765105  0.718
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