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Roberto Zoncu, Ph.D. - Publications

Affiliations: 
Molecular and Cell Biology University of California, Berkeley, Berkeley, CA, United States 
 2007 Yale University, New Haven, CT 
Area:
How organelles sense nutrients and regulate cellular growth
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Goul C, Peruzzo R, Zoncu R. The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease. Nature Reviews. Molecular Cell Biology. PMID 37612414 DOI: 10.1038/s41580-023-00641-8  0.302
2021 Gupta S, Yano J, Mercier V, Htwe HH, Shin HR, Rademaker G, Cakir Z, Ituarte T, Wen KW, Kim GE, Zoncu R, Roux A, Dawson DW, Perera RM. Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth. Nature Cell Biology. PMID 33686253 DOI: 10.1038/s41556-021-00644-7  0.556
2020 Su MY, Fromm SA, Zoncu R, Hurley JH. Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD. Nature. PMID 32848248 DOI: 10.1038/S41586-020-2633-X  0.342
2020 Higuchi-Sanabria R, Shen K, Kelet N, Frankino PA, Durieux J, Bar-Ziv R, Sing CN, Garcia EJ, Homentcovschi S, Sanchez M, Wu R, Tronnes SU, Joe L, Webster B, Ahilon-Jeronimo A, ... ... Zoncu R, et al. Lysosomal recycling of amino acids affects ER quality control. Science Advances. 6: eaaz9805. PMID 32637599 DOI: 10.1126/Sciadv.Aaz9805  0.319
2020 Shin HR, Zoncu R. The Lysosome at the Intersection of Cellular Growth and Destruction. Developmental Cell. PMID 32610045 DOI: 10.1016/J.Devcel.2020.06.010  0.409
2020 Citron YR, Zoncu R. A zinc-sensing protein gives flies a gut feeling for growth. Nature. 580: 187-188. PMID 32203359 DOI: 10.1038/D41586-020-00728-8  0.319
2019 Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R. Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. Science (New York, N.Y.). PMID 31672913 DOI: 10.1126/Science.Aax0364  0.396
2019 Bersuker K, Hendricks J, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. PMID 31634900 DOI: 10.1038/S41586-019-1705-2  0.347
2019 Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R. ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C. Nature Cell Biology. PMID 31548609 DOI: 10.1038/S41556-019-0391-5  0.378
2019 Lawrence RE, Zoncu R. The lysosome as a cellular centre for signalling, metabolism and quality control. Nature Cell Biology. PMID 30602725 DOI: 10.1038/s41556-018-0244-7  0.302
2018 Lawrence RE, Cho KF, Rappold R, Thrun A, Tofaute M, Kim DJ, Moldavski O, Hurley JH, Zoncu R. A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold. Nature Cell Biology. PMID 30061680 DOI: 10.1038/S41556-018-0148-6  0.449
2018 Shin HR, Zoncu R. Finding Sugar in the Pantry: How Galectins Detect and Signal Lysosomal Damage. Molecular Cell. 70: 5-7. PMID 29625038 DOI: 10.1016/J.Molcel.2018.03.017  0.313
2017 De Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo ZQ, Vance RE. Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors. Cell Reports. 21: 2031-2038. PMID 29166595 DOI: 10.1016/J.Celrep.2017.10.088  0.313
2017 Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, ... ... Zoncu R, et al. A unified approach to targeting the lysosome's degradative and growth signaling roles. Cancer Discovery. PMID 28899863 DOI: 10.1158/2159-8290.Cd-17-0741  0.351
2017 Thelen AM, Zoncu R. Emerging Roles for the Lysosome in Lipid Metabolism. Trends in Cell Biology. PMID 28838620 DOI: 10.1016/J.Tcb.2017.07.006  0.373
2017 Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA. DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy. Developmental Cell. 42: 9-21.e5. PMID 28697336 DOI: 10.1016/J.Devcel.2017.06.003  0.342
2017 Di Malta C, Siciliano D, Calcagni A, Monfregola J, Punzi S, Pastore N, Eastes AN, Davis O, De Cegli R, Zampelli A, Di Giovannantonio LG, Nusco E, Platt N, Guida A, Ogmundsdottir MH, ... ... Zoncu R, et al. Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth. Science (New York, N.Y.). 356: 1188-1192. PMID 28619945 DOI: 10.1126/Science.Aag2553  0.393
2017 Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex. Science (New York, N.Y.). 355: 1306-1311. PMID 28336668 DOI: 10.1126/Science.Aag1417  0.401
2017 Belyy V, Shih SM, Bandaria J, Huang Y, Lawrence RE, Zoncu R, Yildiz A. PhotoGate microscopy to track single molecules in crowded environments. Nature Communications. 8: 13978. PMID 28071667 DOI: 10.1038/Ncomms13978  0.309
2016 Manifava M, Smith M, Rotondo S, Walker S, Niewczas I, Zoncu R, Clark J, Ktistakis NT. Dynamics of mTORC1 activation in response to amino acids. Elife. 5. PMID 27725083 DOI: 10.7554/Elife.19960  0.368
2016 Lim CY, Zoncu R. The lysosome as a command-and-control center for cellular metabolism. The Journal of Cell Biology. 214: 653-64. PMID 27621362 DOI: 10.1083/Jcb.201607005  0.395
2016 Perera RM, Zoncu R. The Lysosome as a Regulatory Hub. Annual Review of Cell and Developmental Biology. PMID 27501449 DOI: 10.1146/Annurev-Cellbio-111315-125125  0.42
2016 Young LN, Cho K, Lawrence R, Zoncu R, Hurley JH. Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy. Proceedings of the National Academy of Sciences of the United States of America. PMID 27385829 DOI: 10.1073/Pnas.1603650113  0.334
2015 Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL. Identification of an oncogenic RAB protein. Science (New York, N.Y.). 350: 211-7. PMID 26338797 DOI: 10.1126/Science.Aaa4903  0.414
2015 Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 524: 361-5. PMID 26168401 DOI: 10.1038/Nature14587  0.418
2015 Tooze S, Zoncu R. Control of cellular homeostasis: organelles take the pilot's seat. Molecular Biology of the Cell. 26: 1009-10. PMID 25767200 DOI: 10.1091/Mbc.E14-12-1589  0.368
2015 Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, et al. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science (New York, N.Y.). 347: 188-94. PMID 25567906 DOI: 10.1126/Science.1257132  0.384
2015 Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, et al. Abstract NG08: Transcriptional mechanisms for autophagy regulation and metabolic reprogramming in pancreatic cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Ng08  0.449
2013 Tsun ZY, Bar-Peled L, Chantranupong L, Zoncu R, Wang T, Kim C, Spooner E, Sabatini DM. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Molecular Cell. 52: 495-505. PMID 24095279 DOI: 10.1016/J.Molcel.2013.09.016  0.344
2013 Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y, Schroeder A, Langer R, Anderson DG. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nature Biotechnology. 31: 653-8. PMID 23792629 DOI: 10.1038/Nbt.2614  0.361
2013 Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL, Kirak O, Sabatini DD, Sabatini DM. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature. 493: 679-83. PMID 23263183 DOI: 10.1038/Nature11745  0.35
2012 Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell. 150: 1196-208. PMID 22980980 DOI: 10.1016/J.Cell.2012.07.032  0.356
2012 Efeyan A, Zoncu R, Sabatini DM. Amino acids and mTORC1: from lysosomes to disease. Trends in Molecular Medicine. 18: 524-33. PMID 22749019 DOI: 10.1016/J.Molmed.2012.05.007  0.414
2012 Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, Facchinetti V, Sabatini DM, Ballabio A. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. The Embo Journal. 31: 1095-108. PMID 22343943 DOI: 10.1038/Emboj.2012.32  0.447
2011 Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y, Sabatini DM. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science (New York, N.Y.). 334: 678-83. PMID 22053050 DOI: 10.1126/Science.1207056  0.354
2011 Zoncu R, Sabatini DM. Cell biology. The TASCC of secretion. Science (New York, N.Y.). 332: 923-5. PMID 21596981 DOI: 10.1126/Science.1207552  0.378
2011 Sheen JH, Zoncu R, Kim D, Sabatini DM. Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell. 19: 613-28. PMID 21575862 DOI: 10.1016/J.Ccr.2011.03.012  0.316
2011 Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nature Reviews. Molecular Cell Biology. 12: 21-35. PMID 21157483 DOI: 10.1038/Nrm3025  0.39
2010 Nakatsu F, Perera RM, Lucast L, Zoncu R, Domin J, Gertler FB, Toomre D, De Camilli P. The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. The Journal of Cell Biology. 190: 307-15. PMID 20679431 DOI: 10.1083/Jcb.201005018  0.561
2010 Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 141: 290-303. PMID 20381137 DOI: 10.1016/J.Cell.2010.02.024  0.4
2009 Mao Y, Balkin DM, Zoncu R, Erdmann KS, Tomasini L, Hu F, Jin MM, Hodsdon ME, De Camilli P. A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism. The Embo Journal. 28: 1831-42. PMID 19536138 DOI: 10.1038/Emboj.2009.155  0.488
2009 Zoncu R, Perera RM, Balkin DM, Pirruccello M, Toomre D, De Camilli P. A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes. Cell. 136: 1110-21. PMID 19303853 DOI: 10.1016/J.Cell.2009.01.032  0.567
2007 Erdmann KS, Mao Y, McCrea HJ, Zoncu R, Lee S, Paradise S, Modregger J, Biemesderfer D, Toomre D, De Camilli P. A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway. Developmental Cell. 13: 377-90. PMID 17765681 DOI: 10.1016/J.Devcel.2007.08.004  0.688
2007 Zoncu R, Perera RM, Sebastian R, Nakatsu F, Chen H, Balla T, Ayala G, Toomre D, De Camilli PV. Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate. Proceedings of the National Academy of Sciences of the United States of America. 104: 3793-8. PMID 17360432 DOI: 10.1073/Pnas.0611733104  0.541
2006 Perera RM, Zoncu R, Lucast L, De Camilli P, Toomre D. Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages. Proceedings of the National Academy of Sciences of the United States of America. 103: 19332-7. PMID 17158794 DOI: 10.1073/Pnas.0609795104  0.557
2006 Sebastian R, Díaz E, Ayala G, Díaz ME, Zoncu R, Toomre D. Studying endocytosis in space and time by means of temporal Boolean models Pattern Recognition. 39: 2175-2185. DOI: 10.1016/J.Patcog.2006.04.030  0.312
2002 Di Paolo G, Pellegrini L, Letinic K, Cestra G, Zoncu R, Voronov S, Chang S, Guo J, Wenk MR, De Camilli P. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Nature. 420: 85-9. PMID 12422219 DOI: 10.1038/Nature01147  0.669
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