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Megan L. McCain, Ph.D. - Publications

Affiliations: 
2012 Engineering and Applied Sciences Harvard University, Cambridge, MA, United States 
Area:
cardiac cell biology and tissue engineering, traumatic brain injury, and biological applications of micro- and nanotechnologies
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Maxey AP, Travis JM, McCain ML. Regulation of oxytocin-induced calcium transients and gene expression in engineered myometrial tissues by tissue architecture and matrix rigidity. Current Research in Physiology. 6: 100108. PMID 38107790 DOI: 10.1016/j.crphys.2023.100108  0.374
2023 Bakis I, Sun Y, Abd Elmagid L, Feng X, Garibyan M, Yip J, Yu FZ, Chowdhary S, Fernandez E, Cao J, McCain M, Lien CL, Harrison MR. Methods for dynamic and whole volume imaging of the zebrafish heart. Developmental Biology. PMID 37708968 DOI: 10.1016/j.ydbio.2023.09.002  0.796
2023 Khalil NN, Petersen AP, Song CJ, Chen Y, Takamoto K, Kellogg AC, Chen EZ, McMahon AP, McCain ML. User-friendly microfluidic system reveals native-like morphological and transcriptomic phenotypes induced by shear stress in proximal tubule epithelium. Apl Bioengineering. 7: 036106. PMID 37584027 DOI: 10.1063/5.0143614  0.713
2023 Garibyan M, Hoffman T, Makaske T, Do S, March AR, Cho N, Pedroncelli N, Lima RE, Soto J, Jackson B, Khademhosseini A, Li S, McCain M, Morsut L. Engineering Programmable Material-To-Cell Pathways Via Synthetic Notch Receptors To Spatially Control Cellular Phenotypes In Multi-Cellular Constructs. Biorxiv : the Preprint Server For Biology. PMID 37293089 DOI: 10.1101/2023.05.19.541497  0.74
2022 Rexius-Hall ML, Khalil NN, Escopete SS, Li X, Hu J, Yuan H, Parker SJ, McCain ML. A myocardial infarct border-zone-on-a-chip demonstrates distinct regulation of cardiac tissue function by an oxygen gradient. Science Advances. 8: eabn7097. PMID 36475790 DOI: 10.1126/sciadv.abn7097  0.828
2022 Petersen AP, McCain ML. Quantifying Propagation Velocity from Engineered Cardiac Tissues with High-Speed Fluorescence Microscopy and Automated Analysis Software. Methods in Molecular Biology (Clifton, N.J.). 2485: 133-145. PMID 35618903 DOI: 10.1007/978-1-0716-2261-2_9  0.8
2022 Barthélémy F, Santoso JW, Rabichow L, Jin R, Little I, Nelson SF, McCain ML, Miceli MC. Modeling Patient-Specific Muscular Dystrophy Phenotypes and Therapeutic Responses in Reprogrammed Myotubes Engineered on Micromolded Gelatin Hydrogels. Frontiers in Cell and Developmental Biology. 10: 830415. PMID 35465312 DOI: 10.3389/fcell.2022.830415  0.808
2022 Kapuria S, Bai H, Fierros J, Huang Y, Ma F, Yoshida T, Aguayo A, Kok F, Wiens KM, Yip JK, McCain ML, Pellegrini M, Nagashima M, Hitchcock PF, Mochizuki N, et al. Heterogeneous pdgfrβ+ cells regulate coronary vessel development and revascularization during heart regeneration. Development (Cambridge, England). PMID 35088848 DOI: 10.1242/dev.199752  0.788
2021 Khalil NN, McCain ML. Engineering the Cellular Microenvironment of Post-infarct Myocardium on a Chip. Frontiers in Cardiovascular Medicine. 8: 709871. PMID 34336962 DOI: 10.3389/fcvm.2021.709871  0.309
2021 Santoso JW, Li X, Gupta D, Suh GC, Hendricks E, Lin S, Perry S, Ichida JK, Dickman D, McCain ML. Engineering skeletal muscle tissues with advanced maturity improves synapse formation with human induced pluripotent stem cell-derived motor neurons. Apl Bioengineering. 5: 036101. PMID 34286174 DOI: 10.1063/5.0054984  0.816
2021 Yip JK, Sarkar D, Petersen AP, Gipson JN, Tao J, Kale S, Rexius-Hall ML, Cho N, Khalil NN, Kapadia R, McCain ML. Contact photolithography-free integration of patterned and semi-transparent indium tin oxide stimulation electrodes into polydimethylsiloxane-based heart-on-a-chip devices for streamlining physiological recordings. Lab On a Chip. PMID 33439202 DOI: 10.1039/d0lc00948b  0.777
2021 Gupta D, Santoso JW, McCain ML. Characterization of Gelatin Hydrogels Cross-Linked with Microbial Transglutaminase as Engineered Skeletal Muscle Substrates. Bioengineering (Basel, Switzerland). 8. PMID 33418892 DOI: 10.3390/bioengineering8010006  0.811
2021 Rexius-Hall ML, Ariyasinghe NR, McCain ML. Engineering Shape-Controlled Microtissues on Compliant Hydrogels with Tunable Rigidity and Extracellular Matrix Ligands. Methods in Molecular Biology (Clifton, N.J.). 2258: 57-72. PMID 33340354 DOI: 10.1007/978-1-0716-1174-6_5  0.828
2020 Lyra-Leite DM, Petersen AP, Ariyasinghe NR, Cho N, McCain ML. Mitochondrial architecture in cardiac myocytes depends on cell shape and matrix rigidity. Journal of Molecular and Cellular Cardiology. PMID 33038389 DOI: 10.1016/j.yjmcc.2020.10.004  0.793
2020 Santoso JW, McCain ML. Neuromuscular disease modeling on a chip. Disease Models & Mechanisms. 13. PMID 32817118 DOI: 10.1242/Dmm.044867  0.804
2020 Ariyasinghe NR, Santoso JW, Gupta D, Pincus MJ, August PR, McCain ML. Optical Clearing of Skeletal Muscle Bundles Engineered in 3-D Printed Templates. Annals of Biomedical Engineering. PMID 32748107 DOI: 10.1007/S10439-020-02583-0  0.784
2020 Rexius-Hall ML, Khalil NN, Andres AM, McCain ML. Mitochondrial division inhibitor 1 (mdivi-1) increases oxidative capacity and contractile stress generated by engineered skeletal muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32652761 DOI: 10.1096/Fj.201901039Rr  0.792
2020 Petersen AP, Cho N, Lyra-Leite DM, Santoso JW, Gupta D, Ariyasinghe NR, McCain ML. Regulation of calcium dynamics and propagation velocity by tissue microstructure in engineered strands of cardiac tissue. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 32118279 DOI: 10.1093/Intbio/Zyaa003  0.76
2019 Yip JK, Harrison M, Villafuerte J, Fernandez GE, Petersen AP, Lien CL, McCain ML. Extended culture and imaging of normal and regenerating adult zebrafish hearts in a fluidic device. Lab On a Chip. PMID 31872200 DOI: 10.1039/C9Lc01044K  0.796
2019 Lyra-Leite DM, Andres AM, Cho N, Petersen AP, Ariyasinghe NR, Sarah Kim S, Gottlieb RA, McCain ML. Matrix-Guided Control of Mitochondrial Function in Cardiac Myocytes. Acta Biomaterialia. PMID 31401347 DOI: 10.1016/J.Actbio.2019.08.007  0.81
2019 McCain ML. Cyborg fibroblasts: Cardiac pacemakers of the future? Science Translational Medicine. 11: eaaz3722. DOI: 10.1126/Scitranslmed.Aaz3722  0.424
2019 McCain ML. Placing skin cells on the assembly line for cardiac repair Science Translational Medicine. 11: eaaz0306. DOI: 10.1126/Scitranslmed.Aaz0306  0.404
2019 McCain ML. And the beat goes on Science Translational Medicine. 11: eaax2729. DOI: 10.1126/Scitranslmed.Aax2729  0.34
2018 Petersen AP, Lyra-Leite DM, Ariyasinghe NR, Cho N, Goodwin CM, Kim JY, McCain ML. Microenvironmental Modulation of Calcium Wave Propagation Velocity in Engineered Cardiac Tissues. Cellular and Molecular Bioengineering. 11: 337-352. PMID 31719889 DOI: 10.1007/S12195-018-0522-2  0.801
2018 Ariyasinghe NR, Lyra-Leite DM, McCain ML. Engineering Cardiac Microphysiological Systems to Model Pathological Extracellular Matrix Remodeling. American Journal of Physiology. Heart and Circulatory Physiology. PMID 29906229 DOI: 10.1152/Ajpheart.00110.2018  0.822
2018 Cho N, Razipour SE, McCain ML. TGF-β1 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblasts. Experimental Biology and Medicine (Maywood, N.J.). 1535370218761628. PMID 29504479 DOI: 10.1177/1535370218761628  0.772
2017 Suh GC, Bettadapur A, Santoso JW, McCain ML. Fabrication of Micromolded Gelatin Hydrogels for Long-Term Culture of Aligned Skeletal Myotubes. Methods in Molecular Biology (Clifton, N.J.). 1668: 147-163. PMID 28842908 DOI: 10.1007/978-1-4939-7283-8_11  0.794
2017 Lyra-Leite DM, Andres AM, Petersen AP, Ariyasinghe NR, Cho N, Lee JA, Gottlieb RA, McCain ML. Mitochondrial Function in Engineered Cardiac Tissues is Co-Regulated by Extracellular Matrix Elasticity and Tissue Alignment. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00290.2017. PMID 28733449 DOI: 10.1152/Ajpheart.00290.2017  0.814
2017 Ariyasinghe NR, Reck CH, Viscio AA, Petersen AP, Lyra-Leite DM, Cho N, McCain ML. Engineering micromyocardium to delineate cellular and extracellular regulation of myocardial tissue contractility. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 28726917 DOI: 10.1039/C7Ib00081B  0.811
2017 Sheehy SP, Grosberg A, Qin P, Behm DJ, Ferrier JP, Eagleson MA, Nesmith AP, Krull D, Falls JG, Campbell PH, McCain ML, Willette RN, Hu E, Parker KK. Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes. Experimental Biology and Medicine (Maywood, N.J.). 1535370217701006. PMID 28343439 DOI: 10.1177/1535370217701006  0.712
2016 Bettadapur A, Suh GC, Geisse NA, Wang ER, Hua C, Huber HA, Viscio AA, Kim JY, Strickland JB, McCain ML. Prolonged Culture of Aligned Skeletal Myotubes on Micromolded Gelatin Hydrogels. Scientific Reports. 6: 28855. PMID 27350122 DOI: 10.1038/Srep28855  0.405
2016 Aratyn-Schaus Y, Pasqualini FS, Yuan H, McCain ML, Ye GJ, Sheehy SP, Campbell PH, Parker KK. Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy. The Journal of Cell Biology. PMID 26858266 DOI: 10.1085/Jgp.1473Oia17  0.801
2016 Horton RE, Yadid M, McCain ML, Sheehy SP, Pasqualini FS, Park SJ, Cho A, Campbell P, Parker KK. Angiotensin II Induced Cardiac Dysfunction on a Chip. Plos One. 11: e0146415. PMID 26808388 DOI: 10.1371/Journal.Pone.0146415  0.812
2015 Lee H, Adams WJ, Alford PW, McCain ML, Feinberg AW, Sheehy SP, Goss JA, Parker KK. Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes. Experimental Biology and Medicine (Maywood, N.J.). PMID 25908635 DOI: 10.1177/1535370215583799  0.785
2015 Knight MB, Grosberg A, McCain ML. In vitro tools for quantifying structure-function relationships in cardiac myocyte cells and tissues Cardiac Cytoarchitecture: How to Maintain a Working Heart. 15-39. DOI: 10.1007/978-3-319-15263-9_2  0.448
2014 Nesmith AP, Agarwal A, McCain ML, Parker KK. Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation. Lab On a Chip. 14: 3925-36. PMID 25093641 DOI: 10.1039/C4Lc00688G  0.738
2014 Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nature Medicine. 20: 616-23. PMID 24813252 DOI: 10.1038/Nm.3545  0.816
2014 McCain ML, Desplantez T, Kléber AG. Engineering cardiac cell junctions in vitro to study the intercalated disc. Cell Communication & Adhesion. 21: 181-91. PMID 24754499 DOI: 10.3109/15419061.2014.905931  0.445
2014 McCain ML, Agarwal A, Nesmith HW, Nesmith AP, Parker KK. Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues. Biomaterials. 35: 5462-71. PMID 24731714 DOI: 10.1016/J.Biomaterials.2014.03.052  0.81
2014 McCain ML, Yuan H, Pasqualini FS, Campbell PH, Parker KK. Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. American Journal of Physiology. Heart and Circulatory Physiology. 306: H1525-39. PMID 24682394 DOI: 10.1152/Ajpheart.00799.2013  0.817
2013 Agarwal A, Farouz Y, Nesmith AP, Deravi LF, McCain ML, Parker KK. Micropatterning Alginate Substrates for in vitro Cardiovascular Muscle on a Chip. Advanced Functional Materials. 23: 3738-3746. PMID 26213529 DOI: 10.1002/Adfm.201203319  0.819
2013 Agarwal A, Goss JA, Cho A, McCain ML, Parker KK. Microfluidic heart on a chip for higher throughput pharmacological studies. Lab On a Chip. 13: 3599-608. PMID 23807141 DOI: 10.1039/C3Lc50350J  0.784
2013 McCain ML, Sheehy SP, Grosberg A, Goss JA, Parker KK. Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. Proceedings of the National Academy of Sciences of the United States of America. 110: 9770-5. PMID 23716679 DOI: 10.1073/Pnas.1304913110  0.67
2012 Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A, Dabiri JO, Parker KK. A tissue-engineered jellyfish with biomimetic propulsion. Nature Biotechnology. 30: 792-7. PMID 22820316 DOI: 10.1038/Nbt.2269  0.722
2012 McCain ML, Lee H, Aratyn-Schaus Y, Kléber AG, Parker KK. Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle. Proceedings of the National Academy of Sciences of the United States of America. 109: 9881-6. PMID 22675119 DOI: 10.1073/Pnas.1203007109  0.688
2012 Grosberg A, Nesmith AP, Goss JA, Brigham MD, McCain ML, Parker KK. Muscle on a chip: in vitro contractility assays for smooth and striated muscle. Journal of Pharmacological and Toxicological Methods. 65: 126-35. PMID 22521339 DOI: 10.1016/J.Vascn.2012.04.001  0.625
2012 Beauchamp P, Desplantez T, McCain ML, Li W, Asimaki A, Rigoli G, Parker KK, Saffitz JE, Kleber AG. Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43. Circulation Research. 110: 1445-53. PMID 22518032 DOI: 10.1161/Circresaha.111.259705  0.589
2012 Desplantez T, McCain ML, Beauchamp P, Rigoli G, Rothen-Rutishauser B, Parker KK, Kleber AG. Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current. Cardiovascular Research. 94: 58-65. PMID 22287588 DOI: 10.1093/Cvr/Cvs025  0.541
2012 McCain ML, Desplantez T, Geisse NA, Rothen-Rutishauser B, Oberer H, Parker KK, Kleber AG. Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance. American Journal of Physiology. Heart and Circulatory Physiology. 302: H443-50. PMID 22081700 DOI: 10.1152/Ajpheart.01218.2010  0.582
2011 Grosberg A, Alford PW, McCain ML, Parker KK. Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Lab On a Chip. 11: 4165-73. PMID 22072288 DOI: 10.1039/C1Lc20557A  0.803
2011 McCain ML, Parker KK. Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. PflüGers Archiv : European Journal of Physiology. 462: 89-104. PMID 21499986 DOI: 10.1007/S00424-011-0951-4  0.647
2009 McCain ML, Desplantez T, Geisse NA, Oberer H, Parker KK, Kléber AG. Relating Electrical Conductance, Connexin 43 Immunostaining, and Cell Shape in Micropatterned Cardiac Cell Pairs Biophysical Journal. 96: 285a. DOI: 10.1016/J.Bpj.2008.12.1410  0.597
2008 Hucker WJ, McCain ML, Laughner JI, Iaizzo PA, Efimov IR. Connexin 43 expression delineates two discrete pathways in the human atrioventricular junction. Anatomical Record (Hoboken, N.J. : 2007). 291: 204-15. PMID 18085635 DOI: 10.1002/Ar.20631  0.311
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