| Year |
Citation |
Score |
| 2023 |
Shrestha A, Hwang SY, Kunwar S, Man Kadayat T, Park S, Liu Y, Jo H, Sheen N, Seo M, Lee ES, Kwon Y. Di-indenopyridines as topoisomerase II-selective anticancer agents: Design, synthesis, and structure-activity relationships. Bioorganic & Medicinal Chemistry. 91: 117403. PMID 37418826 DOI: 10.1016/j.bmc.2023.117403 |
0.489 |
|
| 2022 |
Chaudhary CL, Ko S, Lee C, Kim Y, Jung C, Hyun S, Kwon Y, Kang JS, Jung JK, Lee H. Design, Synthesis, and Cytotoxicity and Topoisomerase I/IIα Inhibition Activity of Pyrazolo[4,3-]quinoline Derivatives. Pharmaceuticals (Basel, Switzerland). 15. PMID 35455396 DOI: 10.3390/ph15040399 |
0.468 |
|
| 2022 |
Kunwar S, Hwang SY, Katila P, Man Kadayat T, Jung AR, Kwon Y, Lee ES. Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships. Bioorganic & Medicinal Chemistry Letters. 60: 128606. PMID 35123005 DOI: 10.1016/j.bmcl.2022.128606 |
0.473 |
|
| 2021 |
Jeon KH, Park S, Jang HJ, Hwang SY, Shrestha A, Lee ES, Kwon Y. AK-I-190, a New Catalytic Inhibitor of Topoisomerase II with Anti-Proliferative and Pro-Apoptotic Activity on Androgen-Negative Prostate Cancer Cells. International Journal of Molecular Sciences. 22. PMID 34681904 DOI: 10.3390/ijms222011246 |
0.316 |
|
| 2021 |
Hwang SY, Shrestha A, Park S, Bist G, Kunwar S, Kadayat TM, Jang H, Seo M, Sheen N, Kim S, Jeon KH, Lee ES, Kwon Y. Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors. European Journal of Medicinal Chemistry. 227: 113916. PMID 34678573 DOI: 10.1016/j.ejmech.2021.113916 |
0.449 |
|
| 2021 |
Kunwar S, Hwang SY, Katila P, Park S, Jeon KH, Kim D, Kadayat TM, Kwon Y, Lee ES. Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison. European Journal of Medicinal Chemistry. 226: 113860. PMID 34597897 DOI: 10.1016/j.ejmech.2021.113860 |
0.506 |
|
| 2021 |
Kunwar S, Hwang SY, Katila P, Seo M, Man Kadayat T, Kwon Y, Lee ES. 4-Flourophenyl-substituted 5H-indeno[1,2-b]pyridinols with enhanced topoisomerase IIα inhibitory activity: Synthesis, biological evaluation, and structure-activity relationships. Bioorganic Chemistry. 116: 105349. PMID 34536927 DOI: 10.1016/j.bioorg.2021.105349 |
0.491 |
|
| 2021 |
Jeon KH, Shrestha A, Jang HJ, Kim JA, Sheen N, Seo M, Lee ES, Kwon Y. Anticancer Activity of Indeno[1,2-b]-Pyridinol Derivative as a New DNA Minor Groove Binding Catalytic Inhibitor of Topoisomerase IIα. Biomolecules & Therapeutics. PMID 34011695 DOI: 10.4062/biomolther.2020.231 |
0.403 |
|
| 2021 |
Thapa Magar TB, Hee Seo S, Shrestha A, Kim JA, Kunwar S, Bist G, Kwon Y, Lee ES. Synthesis and structure-activity relationships of hydroxylated and halogenated 2,4-diaryl benzofuro[3,2-b]pyridin-7-ols as selective topoisomerase IIα inhibitors. Bioorganic Chemistry. 111: 104884. PMID 33872925 DOI: 10.1016/j.bioorg.2021.104884 |
0.441 |
|
| 2020 |
Kim EK, Lee KA, Hyeon DY, Kyung M, Jun KY, Seo SH, Hwang D, Kwon Y, Lee WJ. Bacterial Nucleoside Catabolism Controls Quorum Sensing and Commensal-to-Pathogen Transition in the Drosophila Gut. Cell Host & Microbe. PMID 32078802 DOI: 10.1016/J.Chom.2020.01.025 |
0.62 |
|
| 2019 |
Park S, Hwang SY, Shin J, Jo H, Na Y, Kwon Y. A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform. Chemical Communications (Cambridge, England). PMID 31598611 DOI: 10.1039/C9Cc05524J |
0.335 |
|
| 2019 |
Kadayat TM, Park S, Shrestha A, Jo H, Hwang SY, Katila P, Shrestha R, Nepal MR, Noh K, Kim SK, Koh WS, Kim KS, Jeon YH, Jeong TC, Kwon Y, et al. Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2-]pyridinol Derivatives as Potent Topoisomerase IIα-targeted Chemotherapeutic Agents for Breast Cancer. Journal of Medicinal Chemistry. PMID 31398033 DOI: 10.1021/acs.jmedchem.9b00970 |
0.445 |
|
| 2018 |
Cho H, Hee Seo S, Na Y, Kwon Y. The synthesis and anticancer activities of chiral epoxy-substituted chromone analogs. Bioorganic Chemistry. 84: 347-354. PMID 30530076 DOI: 10.1016/J.Bioorg.2018.11.054 |
0.485 |
|
| 2018 |
Shrestha A, Park S, Jang HJ, Katila P, Shrestha R, Kwon Y, Lee ES. A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships. Bioorganic & Medicinal Chemistry. PMID 30262132 DOI: 10.1016/j.bmc.2018.09.021 |
0.448 |
|
| 2018 |
Arepalli SK, Lee C, Sim S, Lee K, Jo H, Jun KY, Kwon Y, Kang JS, Jung JK, Lee H. Development of 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and their salts as potent cytotoxic agents and topoisomerase I/IIα inhibitors. Bioorganic & Medicinal Chemistry. PMID 30253887 DOI: 10.1016/J.Bmc.2018.09.019 |
0.77 |
|
| 2018 |
Shrestha A, Park S, Shin S, Man Kadayat T, Bist G, Katila P, Kwon Y, Lee ES. Design, synthesis, biological evaluation, structure-activity relationship study, and mode of action of 2-phenol-4,6-dichlorophenyl-pyridines. Bioorganic Chemistry. 79: 1-18. PMID 29715635 DOI: 10.1016/j.bioorg.2018.03.033 |
0.491 |
|
| 2018 |
Bae HD, Lee J, Jun KY, Kwon Y, Lee K. Modification of translationally controlled tumor protein-derived protein transduction domain for improved intranasal delivery of insulin. Drug Delivery. 25: 1025-1032. PMID 29688087 DOI: 10.1080/10717544.2018.1464081 |
0.633 |
|
| 2018 |
Magar TBT, Seo SH, Kadayat TM, Jo H, Shrestha A, Bist G, Katila P, Kwon Y, Lee ES. Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase IIα-targeting anticancer agents. Bioorganic & Medicinal Chemistry. PMID 29510948 DOI: 10.1016/j.bmc.2018.02.035 |
0.492 |
|
| 2018 |
Shrestha A, Jo H, Kwon Y, Lee ES. Design, synthesis, and structure-activity relationships of new benzofuro[3,2-b]pyridin-7-ols as DNA topoisomerase II inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29402741 DOI: 10.1016/j.bmcl.2018.01.048 |
0.477 |
|
| 2018 |
Motiur Rahman AFM, Lu Y, Lee HJ, Jo H, Yin W, Alam MS, Cha H, Kadi AA, Kwon Y, Jahng Y. Linear diarylheptanoids as potential anticancer therapeutics: synthesis, biological evaluation, and structure-activity relationship studies. Archives of Pharmacal Research. PMID 29397550 DOI: 10.1007/s12272-018-1004-8 |
0.478 |
|
| 2018 |
Khadka DB, Park S, Jin Y, Han J, Kwon Y, Cho WJ. Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitors. European Journal of Medicinal Chemistry. 143: 200-215. PMID 29174815 DOI: 10.1016/j.ejmech.2017.11.011 |
0.477 |
|
| 2017 |
Choi B, Choi SK, Park YN, Kwak SY, Lee HJ, Kwon Y, Na Y, Lee YS. Sensitization of lung cancer cells by altered dimerization of HSP27. Oncotarget. 8: 105372-105382. PMID 29285257 DOI: 10.18632/Oncotarget.22192 |
0.31 |
|
| 2017 |
Arepalli SK, Park B, Lee K, Jo H, Jun KY, Kwon Y, Kang JS, Jung JK, Lee H. Design, synthesis and biological evaluation of 1,3-diphenylbenzo[f][1,7]naphthyrdines. Bioorganic & Medicinal Chemistry. PMID 28870801 DOI: 10.1016/J.Bmc.2017.08.030 |
0.758 |
|
| 2017 |
Hwang SY, Kwak SY, Kwon Y, Lee YS, Na Y. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shock protein 27. European Journal of Medicinal Chemistry. 139: 892-900. PMID 28869891 DOI: 10.1016/J.Ejmech.2017.08.065 |
0.37 |
|
| 2017 |
Thapa Magar TB, Kadayat TM, Lee HJ, Park S, Bist G, Shrestha A, Kwon Y, Lee ES. 2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent. Bioorganic & Medicinal Chemistry Letters. PMID 28633898 DOI: 10.1016/j.bmcl.2017.06.025 |
0.434 |
|
| 2017 |
Bist G, Park S, Song C, Thapa Magar TB, Shrestha A, Kwon Y, Lee ES. Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity. European Journal of Medicinal Chemistry. 133: 69-84. PMID 28384547 DOI: 10.1016/j.ejmech.2017.03.048 |
0.498 |
|
| 2017 |
Park S, Thapa Magar TB, Kadayat TM, Lee HJ, Bist G, Shrestha A, Lee ES, Kwon Y. Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor. European Journal of Medicinal Chemistry. 127: 318-333. PMID 28068603 DOI: 10.1016/j.ejmech.2017.01.003 |
0.516 |
|
| 2016 |
Jeon KH, Yu HB, Kwak SY, Kwon Y, Na Y. Synthesis and topoisomerases inhibitory activity of heteroaromatic chalcones. Bioorganic & Medicinal Chemistry. PMID 27707625 DOI: 10.1016/J.Bmc.2016.09.051 |
0.454 |
|
| 2016 |
Islam MS, Park S, Song C, Kadi AA, Kwon Y, Rahman AF. Fluorescein hydrazones: A series of novel non-intercalative topoisomerase IIα catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cells. European Journal of Medicinal Chemistry. 125: 49-67. PMID 27654394 DOI: 10.1016/j.ejmech.2016.09.004 |
0.409 |
|
| 2016 |
Park S, Kadayat TM, Jun KY, Thapa Magar TB, Bist G, Shrestha A, Lee ES, Kwon Y. Novel 2-aryl-4-(4'-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors. European Journal of Medicinal Chemistry. 125: 14-28. PMID 27643560 DOI: 10.1016/J.Ejmech.2016.09.019 |
0.77 |
|
| 2016 |
Jun KY, Kwon Y. Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90. Biomolecules & Therapeutics. 24: 453-68. PMID 27582553 DOI: 10.4062/Biomolther.2016.168 |
0.706 |
|
| 2016 |
Park S, Hong E, Kwak SY, Jun KY, Lee ES, Kwon Y, Na Y. Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors. European Journal of Medicinal Chemistry. 123: 211-225. PMID 27484510 DOI: 10.1016/J.Ejmech.2016.07.046 |
0.763 |
|
| 2016 |
Jeon KH, Lee E, Jun KY, Eom JE, Kwak SY, Na Y, Kwon Y. Neuroprotective effect of synthetic chalcone derivatives as competitive dual inhibitors against μ-calpain and cathepsin B through the downregulation of tau phosphorylation and insoluble Aβ peptide formation. European Journal of Medicinal Chemistry. 121: 433-444. PMID 27318120 DOI: 10.1016/J.Ejmech.2016.06.008 |
0.752 |
|
| 2016 |
Thapa P, Kadayat TM, Park S, Shin S, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents. Bioorganic Chemistry. 66: 145-159. PMID 27174797 DOI: 10.1016/J.Bioorg.2016.04.007 |
0.518 |
|
| 2016 |
Ahmad P, Woo H, Jun KY, Kadi AA, Abdel-Aziz HA, Kwon Y, Rahman AF. Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor. Bioorganic & Medicinal Chemistry. PMID 26988802 DOI: 10.1016/j.bmc.2016.03.017 |
0.777 |
|
| 2016 |
Karki R, Jun KY, Kadayat TM, Shin S, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study. European Journal of Medicinal Chemistry. 113: 228-245. PMID 26945111 DOI: 10.1016/J.Ejmech.2016.02.050 |
0.779 |
|
| 2016 |
Kadayat TM, Park S, Jun KY, Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Effect of chlorine substituent on cytotoxic activities: Design and synthesis of systematically modified 2,4-diphenyl-5H-indeno[1,2-b]pyridines. Bioorganic & Medicinal Chemistry Letters. PMID 26927425 DOI: 10.1016/J.Bmcl.2016.02.053 |
0.76 |
|
| 2015 |
Lee BR, Oh IJ, Lee HS, Ban HJ, Kim KS, Kim YI, Lim SC, Kim YC, Park YW, Kwon YS. Usefulness of Rigid Bronchoscopic Intervention Using Argon Plasma Coagulation for Central Airway Tumors. Clinical and Experimental Otorhinolaryngology. 8: 396-401. PMID 26622961 DOI: 10.3342/ceo.2015.8.4.396 |
0.383 |
|
| 2015 |
Min B, Park H, Lee S, Li Y, Choi JM, Lee JY, Kim J, Choi YD, Kwon YG, Lee HW, Bae SC, Yun CO, Chung KC. CHIP-mediated degradation of transglutaminase 2 negatively regulates tumor growth and angiogenesis in renal cancer. Oncogene. PMID 26568304 DOI: 10.1038/onc.2015.439 |
0.441 |
|
| 2015 |
Kwon Y, Song J, Lee H, Kim EY, Lee K, Lee SK, Kim S. Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. Journal of Medicinal Chemistry. PMID 26393416 DOI: 10.1021/acs.jmedchem.5b00764 |
0.385 |
|
| 2015 |
Thapa P, Jun KY, Kadayat TM, Park C, Zheng Z, Thapa Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Design and synthesis of conformationally constrained hydroxylated 4-phenyl-2-aryl chromenopyridines as novel and selective topoisomerase II-targeted antiproliferative agents. Bioorganic & Medicinal Chemistry. PMID 26361737 DOI: 10.1016/J.Bmc.2015.08.018 |
0.765 |
|
| 2015 |
Khadka DB, Tran GH, Shin S, Nguyen HT, Cao HT, Zhao C, Jin Y, Van HT, Chau MV, Kwon Y, Le TN, Cho WJ. Substituted 2-arylquinazolinones: Design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerases. European Journal of Medicinal Chemistry. 103: 69-79. PMID 26334499 DOI: 10.1016/j.ejmech.2015.08.040 |
0.461 |
|
| 2015 |
Kadayat TM, Song C, Kwon Y, Lee ES. Modified 2,4-diaryl-5H-indeno[1,2-b]pyridines with hydroxyl and chlorine moiety: Synthesis, anticancer activity, and structure-activity relationship study. Bioorganic Chemistry. 62: 30-40. PMID 26218799 DOI: 10.1016/j.bioorg.2015.07.002 |
0.449 |
|
| 2015 |
Kadayat TM, Song C, Shin S, Magar TB, Bist G, Shrestha A, Thapa P, Na Y, Kwon Y, Lee ES. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines. Bioorganic & Medicinal Chemistry. 23: 3499-512. PMID 26022080 DOI: 10.1016/J.Bmc.2015.04.031 |
0.487 |
|
| 2015 |
Karki R, Song C, Kadayat TM, Magar TB, Bist G, Shrestha A, Na Y, Kwon Y, Lee ES. Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines. Bioorganic & Medicinal Chemistry. 23: 3638-54. PMID 25936262 DOI: 10.1016/j.bmc.2015.04.002 |
0.495 |
|
| 2015 |
Jun KY, Park SE, Liang JL, Jahng Y, Kwon Y. Benzo[b]tryptanthrin inhibits MDR1, topoisomerase activity, and reverses adriamycin resistance in breast cancer cells. Chemmedchem. 10: 827-35. PMID 25809558 DOI: 10.1002/Cmdc.201500068 |
0.732 |
|
| 2015 |
Khadka DB, Woo H, Yang SH, Zhao C, Jin Y, Le TN, Kwon Y, Cho WJ. Modification of 3-arylisoquinolines into 3,4-diarylisoquinolines and assessment of their cytotoxicity and topoisomerase inhibition. European Journal of Medicinal Chemistry. 92: 583-607. PMID 25613224 DOI: 10.1016/j.ejmech.2015.01.016 |
0.508 |
|
| 2015 |
Kwon HB, Park C, Jeon KH, Lee E, Park SE, Jun KY, Kadayat TM, Thapa P, Karki R, Na Y, Park MS, Rho SB, Lee ES, Kwon Y. A series of novel terpyridine-skeleton molecule derivants inhibit tumor growth and metastasis by targeting topoisomerases. Journal of Medicinal Chemistry. 58: 1100-22. PMID 25603122 DOI: 10.1021/Jm501023Q |
0.747 |
|
| 2015 |
Al-Sanea MM, Elkamhawy A, Zakaria A, Park BS, Kwon Y, Lee SH, Lee SW, Kim IT. Synthesis and in vitro screening of phenylbipyridinylpyrazole derivatives as potential antiproliferative agents. Molecules (Basel, Switzerland). 20: 1031-45. PMID 25584833 DOI: 10.3390/molecules20011031 |
0.444 |
|
| 2015 |
Kadayat TM, Park C, Jun KY, Magar TB, Bist G, Yoo HY, Kwon Y, Lee ES. Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicity. Bioorganic & Medicinal Chemistry. 23: 160-73. PMID 25481396 DOI: 10.1016/J.Bmc.2014.11.010 |
0.779 |
|
| 2015 |
Karki R, Park C, Jun KY, Kadayat TM, Lee ES, Kwon Y. Synthesis and biological activity of 2,4-di-p-phenolyl-6-2-furanyl-pyridine as a potent topoisomerase II poison. European Journal of Medicinal Chemistry. 90: 360-78. PMID 25437622 DOI: 10.1016/J.Ejmech.2014.11.045 |
0.784 |
|
| 2015 |
Kadayat TM, Park C, Jun KY, Thapa Magar TB, Bist G, Yoo HY, Kwon Y, Lee ES. Hydroxylated 2,4-diphenyl indenopyridine derivatives as a selective non-intercalative topoisomerase IIα catalytic inhibitor. European Journal of Medicinal Chemistry. 90: 302-14. PMID 25437617 DOI: 10.1016/J.Ejmech.2014.11.046 |
0.774 |
|
| 2014 |
Jin CH, Jun KY, Lee E, Kim S, Kwon Y, Kim K, Na Y. Ethyl 2-(benzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate analogues as a new scaffold for protein kinase casein kinase 2 inhibitor. Bioorganic & Medicinal Chemistry. 22: 4553-65. PMID 25131958 DOI: 10.1016/J.Bmc.2014.07.037 |
0.755 |
|
| 2014 |
Karki R, Park C, Jun KY, Jee JG, Lee JH, Thapa P, Kadayat TM, Kwon Y, Lee ES. Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors. European Journal of Medicinal Chemistry. 84: 555-65. PMID 25062006 DOI: 10.1016/J.Ejmech.2014.07.058 |
0.783 |
|
| 2014 |
My Van HT, Woo H, Jeong HM, Khadka DB, Yang SH, Zhao C, Jin Y, Lee ES, Youl Lee K, Kwon Y, Cho WJ. Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors. European Journal of Medicinal Chemistry. 82: 181-94. PMID 24904965 DOI: 10.1016/j.ejmech.2014.05.047 |
0.422 |
|
| 2014 |
Jun KY, Kwon H, Park SE, Lee E, Karki R, Thapa P, Lee JH, Lee ES, Kwon Y. Discovery of dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridine as a non-intercalative DNA-binding topoisomerase II-specific catalytic inhibitor. European Journal of Medicinal Chemistry. 80: 428-38. PMID 24796883 DOI: 10.1016/J.Ejmech.2014.04.066 |
0.777 |
|
| 2013 |
Baek KH, Karki R, Lee ES, Na Y, Kwon Y. Synthesis and investigation of dihydroxychalcones as calpain and cathepsin inhibitors. Bioorganic Chemistry. 51: 24-30. PMID 24095934 DOI: 10.1016/J.Bioorg.2013.09.002 |
0.346 |
|
| 2013 |
Abdel-Aziz M, Park SE, Abuo-Rahma Gel-D, Sayed MA, Kwon Y. Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity. European Journal of Medicinal Chemistry. 69: 427-38. PMID 24090914 DOI: 10.1016/j.ejmech.2013.08.040 |
0.415 |
|
| 2013 |
Park SE, Chang IH, Jun KY, Lee E, Lee ES, Na Y, Kwon Y. 3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage. European Journal of Medicinal Chemistry. 69: 139-45. PMID 24013413 DOI: 10.1016/J.Ejmech.2013.07.048 |
0.75 |
|
| 2013 |
Nam JM, Jeon KH, Kwon H, Lee E, Jun KY, Jin YB, Lee YS, Na Y, Kwon Y. Dithiiranylmethyloxy azaxanthone shows potent anti-tumor activity via suppression of HER2 expression and HER2-mediated signals in HER2-overexpressing breast cancer cells. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 50: 181-90. PMID 23835029 DOI: 10.1016/J.Ejps.2013.06.014 |
0.691 |
|
| 2013 |
Kim SH, Lee E, Baek KH, Kwon HB, Woo H, Lee ES, Kwon Y, Na Y. Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents. Bioorganic & Medicinal Chemistry Letters. 23: 3320-4. PMID 23608763 DOI: 10.1016/J.Bmcl.2013.03.106 |
0.408 |
|
| 2013 |
Jeon KH, Jun KY, Kim EY, Kwon Y. Expression and purification of a soluble ESX-binding core domain of SUR2. Preparative Biochemistry & Biotechnology. 43: 364-75. PMID 23464919 DOI: 10.1080/10826068.2012.738273 |
0.667 |
|
| 2013 |
Lee E, Eom JE, Kim HL, Baek KH, Jun KY, Kim HJ, Lee M, Mook-Jung I, Kwon Y. Effect of conjugated linoleic acid, μ-calpain inhibitor, on pathogenesis of Alzheimer's disease. Biochimica Et Biophysica Acta. 1831: 709-18. PMID 23246577 DOI: 10.1016/j.bbalip.2012.12.003 |
0.678 |
|
| 2013 |
Thapa P, Jahng Y, Park PH, Jee JG, Kwon Y, Lee ES. 2,4-Diaryl benzofuro[3,2-b]pyridine derivatives: Design, synthesis, and evaluation of topoisomerase inhibitory activity and cytotoxicity Bulletin of the Korean Chemical Society. 34: 3073-3082. DOI: 10.5012/bkcs.2013.34.10.3073 |
0.465 |
|
| 2012 |
Liang JL, Park SE, Kwon Y, Jahng Y. Synthesis of benzo-annulated tryptanthrins and their biological properties. Bioorganic & Medicinal Chemistry. 20: 4962-7. PMID 22819942 DOI: 10.1016/j.bmc.2012.06.034 |
0.364 |
|
| 2012 |
Kim HL, Jeon KH, Jun KY, Choi Y, Kim DK, Na Y, Kwon Y. A-62176, a potent topoisomerase inhibitor, inhibits the expression of human epidermal growth factor receptor 2. Cancer Letters. 325: 72-9. PMID 22732416 DOI: 10.1016/J.Canlet.2012.06.004 |
0.713 |
|
| 2012 |
Thapa P, Karki R, Yun M, Kadayat TM, Lee E, Kwon HB, Na Y, Cho WJ, Kim ND, Jeong BS, Kwon Y, Lee ES. Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety. European Journal of Medicinal Chemistry. 52: 123-36. PMID 22503656 DOI: 10.1016/J.Ejmech.2012.03.010 |
0.495 |
|
| 2012 |
Lee E, Eom JE, Kim HL, Kang DH, Jun KY, Jung DS, Kwon Y. Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 46: 17-25. PMID 22333440 DOI: 10.1016/J.Ejps.2012.01.015 |
0.69 |
|
| 2012 |
Karki R, Thapa P, Yoo HY, Kadayat TM, Park PH, Na Y, Lee E, Jeon KH, Cho WJ, Choi H, Kwon Y, Lee ES. Dihydroxylated 2,4,6-triphenyl pyridines: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. European Journal of Medicinal Chemistry. 49: 219-28. PMID 22318164 DOI: 10.1016/j.ejmech.2012.01.015 |
0.45 |
|
| 2012 |
Thapa P, Karki R, Yoo HY, Park PH, Lee E, Jeon KH, Na Y, Cho WJ, Kwon Y, Lee ES. 2,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. Bioorganic Chemistry. 40: 67-78. PMID 22000119 DOI: 10.1016/J.Bioorg.2011.09.001 |
0.399 |
|
| 2011 |
Van HT, Khadka DB, Yang SH, Le TN, Cho SH, Zhao C, Lee IS, Kwon Y, Lee KT, Kim YC, Cho WJ. Synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones from 3-arylisoquinolines via ring closing metathesis and evaluation of topoisomerase I inhibitory activity, cytotoxicity and docking study. Bioorganic & Medicinal Chemistry. 19: 5311-20. PMID 21873069 DOI: 10.1016/j.bmc.2011.08.006 |
0.429 |
|
| 2011 |
Rhee HK, Yoo JH, Lee E, Kwon YJ, Seo HR, Lee YS, Choo HY. Synthesis and cytotoxicity of 2-phenylquinazolin-4(3H)-one derivatives. European Journal of Medicinal Chemistry. 46: 3900-8. PMID 21704436 DOI: 10.1016/j.ejmech.2011.05.061 |
0.364 |
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| 2011 |
Le TN, Yang SH, Khadka DB, Van HT, Cho SH, Kwon Y, Lee ES, Lee KT, Cho WJ. Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling. Bioorganic & Medicinal Chemistry. 19: 4399-404. PMID 21684168 DOI: 10.1016/j.bmc.2011.05.012 |
0.373 |
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| 2011 |
Thapa U, Thapa P, Karki R, Yun M, Choi JH, Jahng Y, Lee E, Jeon KH, Na Y, Ha EM, Cho WJ, Kwon Y, Lee ES. Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. European Journal of Medicinal Chemistry. 46: 3201-9. PMID 21601964 DOI: 10.1016/j.ejmech.2011.04.029 |
0.422 |
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| 2011 |
Sapkota K, Roh E, Lee E, Ha EM, Yang JH, Lee ES, Kwon Y, Kim Y, Na Y. Synthesis and anti-melanogenic activity of hydroxyphenyl benzyl ether analogues. Bioorganic & Medicinal Chemistry. 19: 2168-75. PMID 21429753 DOI: 10.1016/J.Bmc.2011.02.044 |
0.413 |
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| 2011 |
Jun KY, Lee EY, Jung MJ, Lee OH, Lee ES, Park Choo HY, Na Y, Kwon Y. Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor. European Journal of Medicinal Chemistry. 46: 1964-71. PMID 21419530 DOI: 10.1016/J.Ejmech.2011.01.011 |
0.77 |
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| 2011 |
Rhee HK, Kwon Y, Chung HJ, Lee SK, Choo HYP. Synthesis, cytotoxicity and topoisomerase II inhibitory activity of benzonaphthofurandiones Bulletin of the Korean Chemical Society. 32: 2391-2396. DOI: 10.5012/bkcs.2011.32.7.2391 |
0.469 |
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| 2010 |
Hong YH, Lee WJ, Lee SH, Son JK, Kim HL, Nam JM, Kwon Y, Jahng Y. Synthesis and biological properties of benzo-annulated rutaecarpines. Biological & Pharmaceutical Bulletin. 33: 1704-9. PMID 20930379 DOI: 10.1248/bpb.33.1704 |
0.328 |
|
| 2010 |
Woo S, Kang DH, Nam JM, Lee CS, Ha EM, Lee ES, Kwon Y, Na Y. Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues. European Journal of Medicinal Chemistry. 45: 4221-8. PMID 20619511 DOI: 10.1016/j.ejmech.2010.06.017 |
0.438 |
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| 2010 |
Choi Y, Jeon S, Choi M, Lee MH, Park M, Lee DR, Jun KY, Kwon Y, Lee OH, Song SH, Kim JY, Lee KA, Yoon TK, Rajkovic A, Shim SH. Mutations in SOHLH1 gene associate with nonobstructive azoospermia. Human Mutation. 31: 788-93. PMID 20506135 DOI: 10.1002/Humu.21264 |
0.632 |
|
| 2010 |
Karki R, Thapa P, Kang MJ, Jeong TC, Nam JM, Kim HL, Na Y, Cho WJ, Kwon Y, Lee ES. Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines. Bioorganic & Medicinal Chemistry. 18: 3066-77. PMID 20392646 DOI: 10.1016/j.bmc.2010.03.051 |
0.411 |
|
| 2010 |
Thapa P, Karki R, Choi H, Choi JH, Yun M, Jeong BS, Jung MJ, Nam JM, Na Y, Cho WJ, Kwon Y, Lee ES. Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship. Bioorganic & Medicinal Chemistry. 18: 2245-54. PMID 20188578 DOI: 10.1016/j.bmc.2010.01.065 |
0.453 |
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| 2010 |
Cho HJ, Jung MJ, Woo S, Kim J, Lee ES, Kwon Y, Na Y. New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers. Bioorganic & Medicinal Chemistry. 18: 1010-7. PMID 20093033 DOI: 10.1016/j.bmc.2009.12.069 |
0.479 |
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| 2010 |
Basnet A, Thapa P, Karki R, Choi H, Choi JH, Yun M, Jeong BS, Jahng Y, Na Y, Cho WJ, Kwon Y, Lee CS, Lee ES. 2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study. Bioorganic & Medicinal Chemistry Letters. 20: 42-7. PMID 19954977 DOI: 10.1016/j.bmcl.2009.11.041 |
0.517 |
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| 2010 |
Thapa P, Karki R, Thapa U, Jahng Y, Jung MJ, Nam JM, Na Y, Kwon Y, Lee ES. 2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study. Bioorganic & Medicinal Chemistry. 18: 377-86. PMID 19939682 DOI: 10.1016/j.bmc.2009.10.049 |
0.497 |
|
| 2010 |
Karki R, Thapa P, Kwon Y, Lee ES. Synthesis, topoisomerase i and II inhibitory activities, and cytotoxicity of 4,6-diaryl-2,4'-bipyridine derivatives Bulletin of the Korean Chemical Society. 31: 1747-1750. DOI: 10.5012/bkcs.2010.31.6.1747 |
0.362 |
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| 2010 |
Sapkota K, Lee E, Yang JH, Kwon Y, Choi J, Na Y. 4-Hydroxy-2'-nitrodiphenyl ether analogues as novel tyrosinase inhibitors Bulletin of the Korean Chemical Society. 31: 1319-1325. DOI: 10.5012/Bkcs.2010.31.5.1319 |
0.408 |
|
| 2009 |
Cho HJ, Jung MJ, Kwon Y, Na Y. Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 6766-9. PMID 19836231 DOI: 10.1016/j.bmcl.2009.09.091 |
0.491 |
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| 2009 |
Rhee HK, Lim SY, Jung MJ, Kwon Y, Kim MH, Choo HY. Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors. Bioorganic & Medicinal Chemistry. 17: 7537-41. PMID 19800803 DOI: 10.1016/j.bmc.2009.09.014 |
0.454 |
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| 2009 |
Kang DH, Jun KY, Lee JP, Pak CS, Na Y, Kwon Y. Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity. Journal of Medicinal Chemistry. 52: 3093-7. PMID 19419206 DOI: 10.1021/Jm8014734 |
0.743 |
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| 2009 |
Lee SH, Van HT, Yang SH, Lee KT, Kwon Y, Cho WJ. Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 2444-7. PMID 19345580 DOI: 10.1016/j.bmcl.2009.03.058 |
0.332 |
|
| 2008 |
Hashem MA, Jun KY, Lee E, Lim S, Choo HY, Kwon Y. A rapid and sensitive screening system for human type I collagen with the aim of discovering potent anti-aging or anti-fibrotic compounds. Molecules and Cells. 26: 625-30. PMID 18810249 |
0.72 |
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| 2008 |
Motiur Rahman AF, Liang JL, Lee SH, Son JK, Jung MJ, Kwon Y, Jahng Y. 2,2-dimethyl-2H-pyran-derived alkaloids I. Practical synthesis of acronycine and benzo[b]acronycine and their biological properties. Archives of Pharmacal Research. 31: 1087-93. PMID 18806949 DOI: 10.1007/s12272-001-1273-7 |
0.364 |
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| 2008 |
Kang DH, Kim JS, Jung MJ, Lee ES, Jahng Y, Kwon Y, Na Y. New insight for fluoroquinophenoxazine derivatives as possibly new potent topoisomerase I inhibitor. Bioorganic & Medicinal Chemistry Letters. 18: 1520-4. PMID 18178085 DOI: 10.1016/j.bmcl.2007.12.053 |
0.494 |
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| 2008 |
Woo S, Kang DH, Kim J, Lee CS, Lee ES, Jahng Y, Kwon Y, Na Y. Synthesis, cytotoxicity and topoisomerase II inhibition study of new thioxanthone analogues Bulletin of the Korean Chemical Society. 29: 471-474. DOI: 10.5012/Bkcs.2008.29.2.471 |
0.435 |
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| 2008 |
Rahman AFMM, Dong HK, Jing LL, Lee ES, Na Y, Jun KY, Kwon Y, Jahng Y. Synthesis and Biological Properties of Luotonin a Derivatives Bulletin of the Korean Chemical Society. 29: 1988-1992. DOI: 10.5012/Bkcs.2008.29.10.1988 |
0.779 |
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| 2007 |
Van HT, Le QM, Lee KY, Lee ES, Kwon Y, Kim TS, Le TN, Lee SH, Cho WJ. Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA-topoisomerase I complex. Bioorganic & Medicinal Chemistry Letters. 17: 5763-7. PMID 17827007 DOI: 10.1016/j.bmcl.2007.08.062 |
0.353 |
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| 2007 |
Cho WJ, Le QM, My Van HT, Youl Lee K, Kang BY, Lee ES, Lee SK, Kwon Y. Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 3531-4. PMID 17498951 DOI: 10.1016/j.bmcl.2007.04.064 |
0.3 |
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| 2007 |
Woo S, Jung J, Lee C, Kwon Y, Na Y. Synthesis of new xanthone analogues and their biological activity test--cytotoxicity, topoisomerase II inhibition, and DNA cross-linking study. Bioorganic & Medicinal Chemistry Letters. 17: 1163-6. PMID 17194586 DOI: 10.1016/j.bmcl.2006.12.030 |
0.443 |
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| 2006 |
Kwon Y, Na Y. Study on the synthesis and cytotoxicity of new quinophenoxazine derivatives. Chemical & Pharmaceutical Bulletin. 54: 248-51. PMID 16462076 DOI: 10.1248/Cpb.54.248 |
0.401 |
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| 2003 |
Kwon Y, Xi Z, Kappen LS, Goldberg IH, Gao X. New complex of post-activated neocarzinostatin chromophore with DNA: bulge DNA binding from the minor groove. Biochemistry. 42: 1186-98. PMID 12564921 DOI: 10.1021/Bi0206210 |
0.592 |
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| 2002 |
Gao X, Stassinopoulos A, Ji J, Kwon Y, Bare S, Goldberg IH. Induced formation of a DNA bulge structure by a molecular wedge ligand-postactivated neocarzinostatin chromophore. Biochemistry. 41: 5131-43. PMID 11955061 DOI: 10.1021/Bi012112O |
0.59 |
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