| Year |
Citation |
Score |
| 2020 |
Neidlin M, Chantzi E, Macheras G, Gustafsson MG, Alexopoulos LG. A Novel Multiplex Based Platform for Osteoarthritis Drug Candidate Evaluation. Annals of Biomedical Engineering. PMID 32472364 DOI: 10.1007/S10439-020-02539-4 |
0.386 |
|
| 2020 |
Chantzi E, Neidlin M, Macheras GA, Alexopoulos LG, Gustafsson MG. COMBSecretomics: A pragmatic methodological framework for higher-order drug combination analysis using secretomics. Plos One. 15: e0232989. PMID 32407402 DOI: 10.1371/Journal.Pone.0232989 |
0.388 |
|
| 2019 |
Sakellaropoulos T, Vougas K, Narang S, Koinis F, Kotsinas A, Polyzos A, Moss TJ, Piha-Paul S, Zhou H, Kardala E, Damianidou E, Alexopoulos LG, Aifantis I, Townsend PA, Panayiotidis MI, et al. A Deep Learning Framework for Predicting Response to Therapy in Cancer. Cell Reports. 29: 3367-3373.e4. PMID 31825821 DOI: 10.1016/J.Celrep.2019.11.017 |
0.335 |
|
| 2019 |
Neidlin M, Dimitrakopoulou S, Alexopoulos LG. Multi-tissue network analysis for drug prioritization in knee osteoarthritis. Scientific Reports. 9: 15176. PMID 31645614 DOI: 10.1038/S41598-019-51627-6 |
0.39 |
|
| 2019 |
Neidlin M, Chantzi E, Macheras G, Gustafsson MG, Alexopoulos LG. An ex vivo tissue model of cartilage degradation suggests that cartilage state can be determined from secreted key protein patterns. Plos One. 14: e0224231. PMID 31634377 DOI: 10.1371/Journal.Pone.0224231 |
0.331 |
|
| 2019 |
Kalli M, Voutouri C, Minia A, Pliaka V, Fotis C, Alexopoulos LG, Stylianopoulos T. Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression. Frontiers in Oncology. 9: 992. PMID 31612114 DOI: 10.3389/Fonc.2019.00992 |
0.302 |
|
| 2019 |
Vougas K, Sakelaropoulos T, Kotsinas A, Foukas GP, Ntargaras A, Koinis F, Polyzos A, Myrianthopoulos V, Zhou H, Narang S, Georgoulias V, Alexopoulos L, Aifantis I, Townsend PA, Sfikakis P, et al. Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining. Pharmacology & Therapeutics. 107395. PMID 31374225 DOI: 10.1016/J.Pharmthera.2019.107395 |
0.366 |
|
| 2019 |
Goulielmaki M, Assimomytis N, Rozanc J, Taki E, Christodoulou I, Alexopoulos LG, Zoumpourlis V, Pintzas A, Papahatjis D. DPS-2: A Novel Dual MEK/ERK and PI3K/AKT Pathway Inhibitor with Powerful Ex Vivo and In Vivo Anticancer Properties. Translational Oncology. 12: 932-950. PMID 31096110 DOI: 10.1016/J.Tranon.2019.04.005 |
0.32 |
|
| 2019 |
Podder B, Guttà C, Rožanc J, Gerlach E, Feoktistova M, Panayotova-Dimitrova D, Alexopoulos LG, Leverkus M, Rehm M. TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma. Cell Death and Differentiation. PMID 30850732 DOI: 10.1038/S41418-019-0315-8 |
0.315 |
|
| 2019 |
Melas IN, Sakellaropoulos T, Hur J, Messinis D, Guo EY, Alexopoulos LG, Bai JPF. A Computational Platform and Guide for Acceleration of Novel Medicines and Personalized Medicine. Methods in Molecular Biology (Clifton, N.J.). 1939: 181-198. PMID 30848462 DOI: 10.1007/978-1-4939-9089-4_10 |
0.745 |
|
| 2019 |
Kalli M, Minia A, Pliaka V, Fotis C, Alexopoulos LG, Stylianopoulos T. Solid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cells. Scientific Reports. 9: 978. PMID 30700740 DOI: 10.1038/S41598-018-37425-6 |
0.316 |
|
| 2018 |
Rožanc J, Sakellaropoulos T, Antoranz A, Guttà C, Podder B, Vetma V, Rufo N, Agostinis P, Pliaka V, Sauter T, Kulms D, Rehm M, Alexopoulos LG. Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma. Cell Death and Differentiation. PMID 30323272 DOI: 10.1038/S41418-018-0210-8 |
0.328 |
|
| 2018 |
Rukhlenko OS, Khorsand F, Krstic A, Rozanc J, Alexopoulos LG, Rauch N, Erickson KE, Hlavacek WS, Posner RG, Gómez-Coca S, Rosta E, Fitzgibbon C, Matallanas D, Rauch J, Kolch W, et al. Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling. Cell Systems. PMID 30007540 DOI: 10.1016/J.Cels.2018.06.002 |
0.347 |
|
| 2018 |
Messinis DE, Melas IN, Hur J, Varshney N, Alexopoulos LG, Bai JPF. Translational systems pharmacology-based predictive assessment of drug-induced cardiomyopathy. Cpt: Pharmacometrics & Systems Pharmacology. PMID 29341478 DOI: 10.1002/psp4.12272 |
0.736 |
|
| 2017 |
Fotis C, Antoranz A, Hatziavramidis D, Sakellaropoulos T, Alexopoulos LG. Pathway-based technologies for early drug discovery. Drug Discovery Today. PMID 29294361 DOI: 10.1016/J.Drudis.2017.12.001 |
0.38 |
|
| 2017 |
Neidlin M, Korcari A, Macheras G, Alexopoulos LG. Cue-Signal-Response Analysis in 3D Chondrocyte Scaffolds with Anabolic Stimuli. Annals of Biomedical Engineering. PMID 29147820 DOI: 10.1007/S10439-017-1964-8 |
0.374 |
|
| 2017 |
Talikka M, Bukharov N, Hayes WS, Hofmann-Apitius M, Alexopoulos L, Peitsch MC, Hoeng J. Novel approaches to develop community-built biological network models for potential drug discovery. Expert Opinion On Drug Discovery. 1-9. PMID 28585481 DOI: 10.1080/17460441.2017.1335302 |
0.379 |
|
| 2017 |
Vetma V, Rožanc J, Charles EM, Hellwig CT, Alexopoulos LG, Rehm M. Examining the In-Vitro Efficacy of the IAP Antagonist Birinapant as a Single-Agent or in Combination with Dacarbazine to Induce Melanoma Cell Death. Oncology Research. PMID 28337955 DOI: 10.3727/096504017X14897145996933 |
0.334 |
|
| 2017 |
Bai JP, Sakellaropoulos T, Alexopoulos LG. A Biologically-Based Computational Approach to Drug Repurposing for Anthrax Infection. Toxins. 9. PMID 28287432 DOI: 10.3390/Toxins9030099 |
0.355 |
|
| 2016 |
Sakellaropoulos T, Herod TJ, Alexopoulos LG, Bai JP. Computed biological relations among 5 select treatment-related organ/tissue toxicities. Chemical Research in Toxicology. PMID 27063352 DOI: 10.1021/Acs.Chemrestox.6B00060 |
0.334 |
|
| 2016 |
Sakellaropoulos T, Hur J, Melas IN, Guo EY, Alexopoulos L, Bohlooly M, Bai JP. Computational Approaches to Accelerating Novel Medicine and Better Patient Care from Bedside to Benchtop. Advances in Protein Chemistry and Structural Biology. 102: 147-79. PMID 26827605 DOI: 10.1016/Bs.Apcsb.2015.09.005 |
0.699 |
|
| 2015 |
Videla S, Konokotina I, Alexopoulos LG, Saez-Rodriguez J, Schaub T, Siegel A, Guziolowski C. Designing Experiments to Discriminate Families of Logic Models. Frontiers in Bioengineering and Biotechnology. 3: 131. PMID 26389116 DOI: 10.3389/Fbioe.2015.00131 |
0.348 |
|
| 2015 |
Stavrakas V, Melas IN, Sakellaropoulos T, Alexopoulos LG. Network reconstruction based on proteomic data and prior knowledge of protein connectivity using graph theory. Plos One. 10: e0128411. PMID 26020784 DOI: 10.1371/Journal.Pone.0128411 |
0.754 |
|
| 2015 |
Melas IN, Sakellaropoulos T, Iorio F, Alexopoulos LG, Loh WY, Lauffenburger DA, Saez-Rodriguez J, Bai JP. Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 25932872 DOI: 10.1039/C4Ib00294F |
0.754 |
|
| 2015 |
Bilal E, Sakellaropoulos T, Melas IN, Messinis DE, Belcastro V, Rhrissorrakrai K, Meyer P, Norel R, Iskandar A, Blaese E, Rice JJ, Peitsch MC, Hoeng J, Stolovitzky G, Alexopoulos LG, et al. A crowd-sourcing approach for the construction of species-specific cell signaling networks. Bioinformatics (Oxford, England). 31: 484-91. PMID 25294919 DOI: 10.1093/Bioinformatics/Btu659 |
0.756 |
|
| 2015 |
Rhrissorrakrai K, Belcastro V, Bilal E, Norel R, Poussin C, Mathis C, Dulize RH, Ivanov NV, Alexopoulos L, Rice JJ, Peitsch MC, Stolovitzky G, Meyer P, Hoeng J. Understanding the limits of animal models as predictors of human biology: lessons learned from the sbv IMPROVER Species Translation Challenge. Bioinformatics (Oxford, England). 31: 471-83. PMID 25236459 DOI: 10.1093/Bioinformatics/Btu611 |
0.365 |
|
| 2015 |
Kotelnikova E, Bernardo-Faura M, Silberberg G, Kiani NA, Messinis D, Melas IN, Artigas L, Schwartz E, Mazo I, Masso M, Alexopoulos LG, Mas JM, Olsson T, Tegner J, Martin R, et al. Signaling networks in MS: a systems-based approach to developing new pharmacological therapies. Multiple Sclerosis (Houndmills, Basingstoke, England). 21: 138-46. PMID 25112814 DOI: 10.1177/1352458514543339 |
0.738 |
|
| 2014 |
Poussin C, Mathis C, Alexopoulos LG, Messinis DE, Dulize RH, Belcastro V, Melas IN, Sakellaropoulos T, Rhrissorrakrai K, Bilal E, Meyer P, Talikka M, Boué S, Norel R, Rice JJ, et al. The species translation challenge-a systems biology perspective on human and rat bronchial epithelial cells. Scientific Data. 1: 140009. PMID 25977767 DOI: 10.1038/Sdata.2014.9 |
0.722 |
|
| 2014 |
Melas IN, Chairakaki AD, Chatzopoulou EI, Messinis DE, Katopodi T, Pliaka V, Samara S, Mitsos A, Dailiana Z, Kollia P, Alexopoulos LG. Modeling of signaling pathways in chondrocytes based on phosphoproteomic and cytokine release data Osteoarthritis and Cartilage. 22: 509-518. PMID 24457104 DOI: 10.1016/J.Joca.2014.01.001 |
0.386 |
|
| 2014 |
Morris MK, Chi A, Melas IN, Alexopoulos LG. Phosphoproteomics in drug discovery. Drug Discovery Today. 19: 425-32. PMID 24141136 DOI: 10.1016/J.Drudis.2013.10.010 |
0.732 |
|
| 2014 |
Samara S, Chatzopoulou E, Melas I, Messinis D, Dailiana Z, Kollia P, Alexopoulos L. Meniscus - Cartilage paracrine crosstalk in osteoarthritis Bone Abstracts. DOI: 10.1530/Boneabs.3.Pp183 |
0.703 |
|
| 2013 |
Melas IN, Lauffenburger DA, Alexopoulos LG. Identification of signaling pathways related to drug efficacy in hepatocellular carcinoma via integration of phosphoproteomic, genomic and clinical data. Proceedings / Annual Ieee International Symposium On Bioinformatics and Bioengineering (Bibe). Ieee International Symposium On Bioinformatics and Bioengineering. 2013. PMID 25729777 DOI: 10.1109/BIBE.2013.6701683 |
0.708 |
|
| 2013 |
Melas IN, Samaga R, Alexopoulos LG, Klamt S. Detecting and removing inconsistencies between experimental data and signaling network topologies using integer linear programming on interaction graphs. Plos Computational Biology. 9: e1003204. PMID 24039561 DOI: 10.1371/Journal.Pcbi.1003204 |
0.74 |
|
| 2013 |
Melas IN, Kretsos K, Alexopoulos LG. Leveraging systems biology approaches in clinical pharmacology. Biopharmaceutics & Drug Disposition. 34: 477-88. PMID 23983165 DOI: 10.1002/Bdd.1859 |
0.736 |
|
| 2013 |
Poussin C, Alexopoulos L, Belcastro V, Bilal E, Mathis C, Meyer P, Norel R, Rice JJ, Stolovitzky G, Hoeng J, Peitsch M. Translational systems biology understanding the limits of animal models as predictors of human biology Embnet.Journal. 19: 30. DOI: 10.14806/Ej.19.A.624 |
0.332 |
|
| 2012 |
Mitsos A, Melas IN, Morris MK, Saez-Rodriguez J, Lauffenburger DA, Alexopoulos LG. Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways. Plos One. 7: e50085. PMID 23226239 DOI: 10.1371/Journal.Pone.0050085 |
0.75 |
|
| 2012 |
Melas IN, Mitsos A, Messinis DE, Weiss TS, Rodriguez JS, Alexopoulos LG. Construction of large signaling pathways using an adaptive perturbation approach with phosphoproteomic data. Molecular Biosystems. 8: 1571-84. PMID 22446821 DOI: 10.1039/C2Mb05482E |
0.751 |
|
| 2011 |
Melas IN, Chairakaki AD, Mitsos A, Dailiana Z, Provatidis CG, Alexopoulos LG. Modeling signaling pathways in articular cartilage. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2011: 3712-5. PMID 22255146 DOI: 10.1109/IEMBS.2011.6090630 |
0.749 |
|
| 2011 |
Ryll A, Samaga R, Schaper F, Alexopoulos LG, Klamt S. Large-scale network models of IL-1 and IL-6 signalling and their hepatocellular specification Molecular Biosystems. 7: 3253-3270. PMID 21968890 DOI: 10.1039/C1Mb05261F |
0.333 |
|
| 2011 |
Prill RJ, Saez-Rodriguez J, Alexopoulos LG, Sorger PK, Stolovitzky G. Crowdsourcing network inference: the DREAM predictive signaling network challenge. Science Signaling. 4: mr7. PMID 21900204 DOI: 10.1126/Scisignal.2002212 |
0.371 |
|
| 2011 |
Saez-Rodriguez J, Alexopoulos LG, Zhang M, Morris MK, Lauffenburger DA, Sorger PK. Comparing signaling networks between normal and transformed hepatocytes using discrete logical models. Cancer Research. 71: 5400-11. PMID 21742771 DOI: 10.1158/0008-5472.Can-10-4453 |
0.407 |
|
| 2011 |
Melas IN, Mitsos A, Messinis DE, Weiss TS, Alexopoulos LG. Combined logical and data-driven models for linking signalling pathways to cellular response. Bmc Systems Biology. 5: 107. PMID 21729292 DOI: 10.1186/1752-0509-5-107 |
0.753 |
|
| 2011 |
Saez-Rodriguez J, Alexopoulos LG, Stolovitzky G. Setting the standards for signal transduction research. Science Signaling. 4: pe10. PMID 21325202 DOI: 10.1126/Scisignal.2001844 |
0.355 |
|
| 2010 |
Alexopoulos LG, Melas IN, Chairakaki AD, Saez-Rodriguez J, Mitsos A. Construction of signaling pathways and identification of drug effects on the liver cancer cell HepG2. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2010: 6717-20. PMID 21096084 DOI: 10.1109/IEMBS.2010.5626246 |
0.752 |
|
| 2010 |
Alexopoulos LG, Saez-Rodriguez J, Cosgrove BD, Lauffenburger DA, Sorger PK. Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes. Molecular & Cellular Proteomics : McP. 9: 1849-65. PMID 20460255 DOI: 10.1074/Mcp.M110.000406 |
0.399 |
|
| 2010 |
Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA. Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. Molecular Biosystems. 6: 1195-206. PMID 20361094 DOI: 10.1039/B926287C |
0.421 |
|
| 2010 |
Prill RJ, Marbach D, Saez-Rodriguez J, Sorger PK, Alexopoulos LG, Xue X, Clarke ND, Altan-Bonnet G, Stolovitzky G. Towards a rigorous assessment of systems biology models: the DREAM3 challenges. Plos One. 5: e9202. PMID 20186320 DOI: 10.1371/Journal.Pone.0009202 |
0.345 |
|
| 2010 |
Alexopoulos L, Chairakaki A, Melas I, Provatidis C, Kolia P, Dailiana Z. 280 Systems Biology Approach and High-throughput Proteomic Analysis Identifies Toll-Like-Receptor Activators as Major Players of Cartilage Degeneration Osteoarthritis and Cartilage. 18. DOI: 10.1016/S1063-4584(10)60307-X |
0.709 |
|
| 2009 |
Mitsos A, Melas IN, Siminelakis P, Chairakaki AD, Saez-Rodriguez J, Alexopoulos LG. Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data. Plos Computational Biology. 5: e1000591. PMID 19997482 DOI: 10.1371/Journal.Pcbi.1000591 |
0.756 |
|
| 2009 |
Cosgrove BD, Alexopoulos LG, Saez-Rodriguez J, Griffith LG, Lauffenburger DA. A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 5452-5. PMID 19964679 DOI: 10.1109/IEMBS.2009.5334019 |
0.31 |
|
| 2009 |
Saez-Rodriguez J, Alexopoulos LG, Epperlein J, Samaga R, Lauffenburger DA, Klamt S, Sorger PK. Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction. Molecular Systems Biology. 5: 331. PMID 19953085 DOI: 10.1038/Msb.2009.87 |
0.419 |
|
| 2009 |
Samaga R, Saez-Rodriguez J, Alexopoulos LG, Sorger PK, Klamt S. The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data. Plos Computational Biology. 5: e1000438. PMID 19662154 DOI: 10.1371/Journal.Pcbi.1000438 |
0.409 |
|
| 2009 |
Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicology and Applied Pharmacology. 237: 317-30. PMID 19362101 DOI: 10.1016/J.Taap.2009.04.002 |
0.339 |
|
| 2009 |
Alexopoulos LG, Youn I, Bonaldo P, Guilak F. Developmental and osteoarthritic changes in Col6a1-knockout mice: biomechanics of type VI collagen in the cartilage pericellular matrix. Arthritis and Rheumatism. 60: 771-9. PMID 19248115 DOI: 10.1002/Art.24293 |
0.68 |
|
| 2006 |
Guilak F, Alexopoulos LG, Upton ML, Youn I, Choi JB, Cao L, Setton LA, Haider MA. The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage. Annals of the New York Academy of Sciences. 1068: 498-512. PMID 16831947 DOI: 10.1196/Annals.1346.011 |
0.694 |
|
| 2006 |
Qi J, Fox AM, Alexopoulos LG, Chi L, Bynum D, Guilak F, Banes AJ. IL-1beta decreases the elastic modulus of human tenocytes. Journal of Applied Physiology (Bethesda, Md. : 1985). 101: 189-95. PMID 16627678 DOI: 10.1152/Japplphysiol.01128.2005 |
0.452 |
|
| 2006 |
Trickey WR, Baaijens FP, Laursen TA, Alexopoulos LG, Guilak F. Determination of the Poisson's ratio of the cell: recovery properties of chondrocytes after release from complete micropipette aspiration. Journal of Biomechanics. 39: 78-87. PMID 16271590 DOI: 10.1016/J.Jbiomech.2004.11.006 |
0.75 |
|
| 2006 |
Trickey WR, Baaijens FPT, Laursen TA, Alexopoulos LG, Guilak F. Response to Dr. Schachar Journal of Biomechanics. 39: 2344-2345. DOI: 10.1016/J.Jbiomech.2006.06.002 |
0.72 |
|
| 2005 |
Alexopoulos LG, Setton LA, Guilak F. The biomechanical role of the chondrocyte pericellular matrix in articular cartilage. Acta Biomaterialia. 1: 317-25. PMID 16701810 DOI: 10.1016/J.Actbio.2005.02.001 |
0.506 |
|
| 2005 |
Guilak F, Alexopoulos LG, Haider MA, Ting-Beall HP, Setton LA. Zonal uniformity in mechanical properties of the chondrocyte pericellular matrix: micropipette aspiration of canine chondrons isolated by cartilage homogenization. Annals of Biomedical Engineering. 33: 1312-8. PMID 16240080 DOI: 10.1007/S10439-005-4479-7 |
0.509 |
|
| 2005 |
Alexopoulos LG, Williams GM, Upton ML, Setton LA, Guilak F. Osteoarthritic changes in the biphasic mechanical properties of the chondrocyte pericellular matrix in articular cartilage. Journal of Biomechanics. 38: 509-17. PMID 15652549 DOI: 10.1016/J.Jbiomech.2004.04.012 |
0.517 |
|
| 2003 |
Alexopoulos LG, Haider MA, Vail TP, Guilak F. Alterations in the mechanical properties of the human chondrocyte pericellular matrix with osteoarthritis. Journal of Biomechanical Engineering. 125: 323-33. PMID 12929236 DOI: 10.1115/1.1579047 |
0.516 |
|
| 2002 |
Alexopoulos LG, Erickson GR, Guilak F. A method for quantifying cell size from differential interference contrast images: validation and application to osmotically stressed chondrocytes. Journal of Microscopy. 205: 125-35. PMID 11879427 DOI: 10.1046/J.0022-2720.2001.00976.X |
0.747 |
|
| 2001 |
Erickson GR, Alexopoulos LG, Guilak F. Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways. Journal of Biomechanics. 34: 1527-35. PMID 11716854 DOI: 10.1016/S0021-9290(01)00156-7 |
0.749 |
|
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