| Year |
Citation |
Score |
| 2017 |
Ugbode CI, Smith I, Whalley BJ, Hirst WD, Rattray M. SHH signalling mediates astrocyte crosstalk with neurons to confer neuroprotection. Journal of Neurochemistry. PMID 28485896 DOI: 10.1111/Jnc.14064 |
0.379 |
|
| 2016 |
Volpicelli-Daley LA, Abdelmotilib H, Liu Z, Stoyka L, Daher JP, Milnerwood AJ, Unni VK, Hirst WD, Yue Z, Zhao HT, Fraser K, Kennedy RE, West AB. G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7415-27. PMID 27413152 DOI: 10.1523/Jneurosci.3642-15.2016 |
0.319 |
|
| 2015 |
Delenclos M, Trendafilova T, Jones DR, Moussaud S, Baine AM, Yue M, Hirst WD, McLean PJ. A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo. Frontiers in Neuroscience. 9: 511. PMID 26834539 DOI: 10.3389/Fnins.2015.00511 |
0.32 |
|
| 2015 |
Norkett R, Modi S, Birsa N, Atkin TA, Ivankovic D, Pathania M, Trossbach SV, Korth C, Hirst WD, Kittler JT. DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites. The Journal of Biological Chemistry. PMID 26553875 DOI: 10.1074/Jbc.M115.699447 |
0.309 |
|
| 2015 |
Henry AG, Aghamohammadzadeh S, Samaroo H, Chen Y, Mou K, Needle E, Hirst WD. Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression. Human Molecular Genetics. 24: 6013-28. PMID 26251043 DOI: 10.1093/Hmg/Ddv314 |
0.331 |
|
| 2015 |
Daher JP, Abdelmotilib HA, Hu X, Volpicelli-Daley LA, Moehle MS, Fraser KB, Needle E, Chen Y, Steyn SJ, Galatsis P, Hirst WD, West AB. LRRK2 Pharmacological Inhibition Abates α-Synuclein Induced Neurodegeneration. The Journal of Biological Chemistry. PMID 26078453 DOI: 10.1074/Jbc.M115.660001 |
0.34 |
|
| 2015 |
Henderson JL, Kormos BL, Hayward MM, Coffman KJ, Jasti J, Kurumbail RG, Wager TT, Verhoest PR, Noell GS, Chen Y, Needle E, Berger Z, Steyn SJ, Houle C, Hirst WD, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. Journal of Medicinal Chemistry. 58: 419-32. PMID 25353650 DOI: 10.1021/Jm5014055 |
0.317 |
|
| 2014 |
Ugbode CI, Hirst WD, Rattray M. Neuronal influences are necessary to produce mitochondrial co-localization with glutamate transporters in astrocytes. Journal of Neurochemistry. 130: 668-77. PMID 24814819 DOI: 10.1111/Jnc.12759 |
0.342 |
|
| 2014 |
Birsa N, Norkett R, Wauer T, Mevissen TE, Wu HC, Foltynie T, Bhatia K, Hirst WD, Komander D, Plun-Favreau H, Kittler JT. Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. The Journal of Biological Chemistry. 289: 14569-82. PMID 24671417 DOI: 10.1074/Jbc.M114.563031 |
0.325 |
|
| 2014 |
Shen W, Henry AG, Paumier KL, Li L, Mou K, Dunlop J, Berger Z, Hirst WD. Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons. Journal of Neurochemistry. 129: 884-94. PMID 24494600 DOI: 10.1111/Jnc.12672 |
0.638 |
|
| 2014 |
McFarland NR, Dimant H, Kibuuka L, Ebrahimi-Fakhari D, Desjardins CA, Danzer KM, Danzer M, Fan Z, Schwarzschild MA, Hirst W, McLean PJ. Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss. Plos One. 9: e86048. PMID 24465863 DOI: 10.1371/Journal.Pone.0086048 |
0.326 |
|
| 2014 |
Luerman GC, Nguyen C, Samaroo H, Loos P, Xi H, Hurtado-Lorenzo A, Needle E, Stephen Noell G, Galatsis P, Dunlop J, Geoghegan KF, Hirst WD. Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1. Journal of Neurochemistry. 128: 561-76. PMID 24117733 DOI: 10.1111/Jnc.12483 |
0.355 |
|
| 2014 |
Galatsis P, Henderson J, Kormos BL, Hirst WD. Development of LRRK2 kinase inhibitors for parkinson's disease Annual Reports in Medicinal Chemistry. 49: 43-58. DOI: 10.1016/B978-0-12-800167-7.00004-3 |
0.311 |
|
| 2013 |
Li L, Nadanaciva S, Berger Z, Shen W, Paumier K, Schwartz J, Mou K, Loos P, Milici AJ, Dunlop J, Hirst WD. Human A53T α-synuclein causes reversible deficits in mitochondrial function and dynamics in primary mouse cortical neurons. Plos One. 8: e85815. PMID 24392030 DOI: 10.1371/Journal.Pone.0085815 |
0.634 |
|
| 2010 |
Childers WE, Havran LM, Asselin M, Bicksler JJ, Chong DC, Grosu GT, Shen Z, Abou-Gharbia MA, Bach AC, Harrison BL, Kagan N, Kleintop T, Magolda R, Marathias V, Robichaud AJ, ... ... Hirst WD, et al. The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists. Journal of Medicinal Chemistry. 53: 4066-84. PMID 20443629 DOI: 10.1021/Jm1000908 |
0.319 |
|
| 2008 |
Liu F, Day M, Muñiz LC, Bitran D, Arias R, Revilla-Sanchez R, Grauer S, Zhang G, Kelley C, Pulito V, Sung A, Mervis RF, Navarra R, Hirst WD, Reinhart PH, et al. Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nature Neuroscience. 11: 334-43. PMID 18297067 DOI: 10.1038/Nn2057 |
0.307 |
|
| 2008 |
Ray AM, Hirst WD, Ahmed M, Johnson CN, Witty DR, Sunter D, Quinn LP, Stean TO, Trail BK, Foley A, Upton N, Medhurst AD, Chuang TT. P4-327: Effects of the novel 5-HT6
SB-742457 antagonist and the cholinesterase inhibitor donepezil in models of cognition Alzheimer's & Dementia. 4: T768-T768. DOI: 10.1016/J.Jalz.2008.05.2397 |
0.317 |
|
| 2007 |
Medhurst AD, Atkins AR, Beresford IJ, Brackenborough K, Briggs MA, Calver AR, Cilia J, Cluderay JE, Crook B, Davis JB, Davis RK, Davis RP, Dawson LA, Foley AG, Gartlon J, ... ... Hirst WD, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. The Journal of Pharmacology and Experimental Therapeutics. 321: 1032-45. PMID 17327487 DOI: 10.1124/Jpet.107.120311 |
0.329 |
|
| 2007 |
Medhurst AD, Briggs MA, Bruton G, Calver AR, Chessell I, Crook B, Davis JB, Davis RP, Foley AG, Heslop T, Hirst WD, Medhurst SJ, Ociepka S, Ray A, Regan CM, et al. Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats. Biochemical Pharmacology. 73: 1182-94. PMID 17276409 DOI: 10.1016/J.Bcp.2007.01.007 |
0.328 |
|
| 2006 |
Hirst WD, Stean TO, Rogers DC, Sunter D, Pugh P, Moss SF, Bromidge SM, Riley G, Smith DR, Bartlett S, Heidbreder CA, Atkins AR, Lacroix LP, Dawson LA, Foley AG, et al. SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. European Journal of Pharmacology. 553: 109-19. PMID 17069795 DOI: 10.1016/J.Ejphar.2006.09.049 |
0.378 |
|
| 2006 |
Marcos B, Gil-Bea FJ, Hirst WD, GarcÃa-Alloza M, RamÃrez MJ. Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release. The European Journal of Neuroscience. 24: 1299-306. PMID 16987217 DOI: 10.1111/J.1460-9568.2006.05003.X |
0.389 |
|
| 2004 |
Gadalla AE, Pearson T, Currie AJ, Dale N, Hawley SA, Sheehan M, Hirst W, Michel AD, Randall A, Hardie DG, Frenguelli BG. AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus. Journal of Neurochemistry. 88: 1272-82. PMID 15009683 DOI: 10.1046/J.1471-4159.2003.02253.X |
0.351 |
|
| 2004 |
Foley AG, Murphy KJ, Hirst WD, Gallagher HC, Hagan JJ, Upton N, Walsh FS, Regan CM. The 5-HT(6) receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 93-100. PMID 14571256 DOI: 10.1038/Sj.Npp.1300332 |
0.303 |
|
| 2004 |
Garcia-Alloza M, Hirst WD, Chen CP, Lasheras B, Francis PT, RamÃrez MJ. Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 410-6. PMID 14571255 DOI: 10.1038/Sj.Npp.1300330 |
0.349 |
|
| 2003 |
Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD. Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Molecular Pharmacology. 64: 1295-308. PMID 14645659 DOI: 10.1124/Mol.64.6.1295 |
0.398 |
|
| 2003 |
Hirst WD, Babbs AJ, Green A, Minton JA, Shaw TE, Wise A, Rice SQ, Pangalos MN, Price GW. Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits. Biochemical Pharmacology. 65: 1103-13. PMID 12663046 DOI: 10.1016/S0006-2952(02)01658-1 |
0.332 |
|
| 2002 |
Couve A, Thomas P, Calver AR, Hirst WD, Pangalos MN, Walsh FS, Smart TG, Moss SJ. Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling. Nature Neuroscience. 5: 415-24. PMID 11976702 DOI: 10.1038/Nn833 |
0.344 |
|
| 2002 |
Stean TO, Hirst WD, Thomas DR, Price GW, Rogers D, Riley G, Bromidge SM, Serafinowska HT, Smith DR, Bartlett S, Deeks N, Duxon M, Upton N. Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist. Pharmacology, Biochemistry, and Behavior. 71: 645-54. PMID 11888556 DOI: 10.1016/S0091-3057(01)00742-0 |
0.398 |
|
| 2001 |
Lanneau C, Green A, Hirst WD, Wise A, Brown JT, Donnier E, Charles KJ, Wood M, Davies CH, Pangalos MN. Gabapentin is not a GABAB receptor agonist. Neuropharmacology. 41: 965-75. PMID 11747901 DOI: 10.1016/S0028-3908(01)00140-X |
0.305 |
|
| 2000 |
Langmead CJ, Szekeres PG, Chambers JK, Ratcliffe SJ, Jones DN, Hirst WD, Price GW, Herdon HJ. Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. British Journal of Pharmacology. 131: 683-8. PMID 11030716 DOI: 10.1038/Sj.Bjp.0703617 |
0.342 |
|
| 2000 |
Routledge C, Bromidge SM, Moss SF, Price GW, Hirst W, Newman H, Riley G, Gager T, Stean T, Upton N, Clarke SE, Brown AM, Middlemiss DN. Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist. British Journal of Pharmacology. 130: 1606-12. PMID 10928964 DOI: 10.1038/Sj.Bjp.0703457 |
0.394 |
|
| 2000 |
Hirst WD, Minton JA, Bromidge SM, Moss SF, Latter AJ, Riley G, Routledge C, Middlemiss DN, Price GW. Characterization of [(125)I]-SB-258585 binding to human recombinant and native 5-HT(6) receptors in rat, pig and human brain tissue. British Journal of Pharmacology. 130: 1597-605. PMID 10928963 DOI: 10.1038/Sj.Bjp.0703458 |
0.389 |
|
| 2000 |
Bendotti C, Guglielmetti F, Tortarolo M, Samanin R, Hirst WD. Differential expression of S100beta and glial fibrillary acidic protein in the hippocampus after kainic acid-induced lesions and mossy fiber sprouting in adult rat. Experimental Neurology. 161: 317-29. PMID 10683297 DOI: 10.1006/Exnr.1999.7262 |
0.341 |
|
| 1999 |
Medhurst AD, Hirst WD, Jerman JC, Meakin J, Roberts JC, Testa T, Smart D. Molecular and pharmacological characterization of a functional tachykinin NK3 receptor cloned from the rabbit iris sphincter muscle. British Journal of Pharmacology. 128: 627-36. PMID 10516642 DOI: 10.1038/Sj.Bjp.0702854 |
0.307 |
|
| 1999 |
Young KA, Hirst WD, Solito E, Wilkin GP. De novo expression of lipocortin-1 in reactive microglia and astrocytes in kainic acid lesioned rat cerebellum. Glia. 26: 333-43. PMID 10383052 DOI: 10.1002/(Sici)1098-1136(199906)26:4<333::Aid-Glia7>3.0.Co;2-S |
0.582 |
|
| 1999 |
Hirst WD, Young KA, Newton R, Allport VC, Marriott DR, Wilkin GP. Expression of COX-2 by normal and reactive astrocytes in the adult rat central nervous system. Molecular and Cellular Neurosciences. 13: 57-68. PMID 10049531 DOI: 10.1006/Mcne.1998.0731 |
0.6 |
|
| 1998 |
Hirst WD, Cheung NY, Rattray M, Price GW, Wilkin GP. Cultured astrocytes express messenger RNA for multiple serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes to adenylyl cyclase. Brain Research. Molecular Brain Research. 61: 90-9. PMID 9795156 DOI: 10.1016/S0169-328X(98)00206-X |
0.617 |
|
| 1998 |
Hirst WD, Price GW, Rattray M, Wilkin GP. Serotonin transporters in adult rat brain astrocytes revealed by [3H]5-HT uptake into glial plasmalemmal vesicles. Neurochemistry International. 33: 11-22. PMID 9694037 DOI: 10.1016/S0197-0186(05)80003-8 |
0.617 |
|
| 1998 |
Davletov BA, Meunier FA, Ashton AC, Matsushita H, Hirst WD, Lelianova VG, Wilkin GP, Dolly JO, Ushkaryov YA. Vesicle exocytosis stimulated by alpha-latrotoxin is mediated by latrophilin and requires both external and stored Ca2+. The Embo Journal. 17: 3909-20. PMID 9670008 DOI: 10.1093/Emboj/17.14.3909 |
0.511 |
|
| 1997 |
Hirst WD, Price GW, Rattray M, Wilkin GP. Identification of 5-hydroxytryptamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes. British Journal of Pharmacology. 120: 509-15. PMID 9031757 DOI: 10.1038/Sj.Bjp.0700921 |
0.624 |
|
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