Shankar Subramaniam - Publications

Affiliations: 
Bioengineering University of California, San Diego, La Jolla, CA 
Area:
Biomedical Engineering, Biomechanics Biophysics

75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Valdes P, Henry KW, Fitzgerald MQ, Muralidharan K, Caldwell AB, Ramachandran S, Goldstein LSB, Mobley WC, Galasko DR, Subramaniam S. Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease. Molecular Brain. 16: 75. PMID 37924159 DOI: 10.1186/s13041-023-01063-5  0.637
2023 Patel AO, Caldwell AB, Ramachandran S, Subramaniam S. Endotype Characterization Reveals Mechanistic Differences Across Brain Regions in Sporadic Alzheimer's Disease. Journal of Alzheimer's Disease Reports. 7: 957-972. PMID 37849634 DOI: 10.3233/ADR-220098  0.635
2023 Dwivedi I, Caldwell AB, Zhou D, Wu W, Subramaniam S, Haddad GG. Methadone alters transcriptional programs associated with synapse formation in human cortical organoids. Translational Psychiatry. 13: 151. PMID 37147277 DOI: 10.1038/s41398-023-02397-3  0.661
2022 Caldwell AB, Anantharaman BG, Ramachandran S, Nguyen P, Liu Q, Trinh I, Galasko DR, Desplats PA, Wagner SL, Subramaniam S. Transcriptomic profiling of sporadic Alzheimer's disease patients. Molecular Brain. 15: 83. PMID 36224601 DOI: 10.1186/s13041-022-00963-2  0.63
2022 Azad P, Caldwell AB, Ramachandran S, Spann NJ, Akbari A, Villafuerte FC, Bermudez D, Zhao H, Poulsen O, Zhou D, Bafna V, Subramaniam S, Haddad GG. ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge's disease. Experimental & Molecular Medicine. PMID 35672450 DOI: 10.1038/s12276-022-00769-1  0.654
2022 Caldwell AB, Liu Q, Zhang C, Schroth GP, Galasko DR, Rynearson KD, Tanzi RE, Yuan SH, Wagner SL, Subramaniam S. Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35084109 DOI: 10.1002/alz.12553  0.634
2021 Raghunandan S, Ramachandran S, Ke E, Miao Y, Lal R, Chen ZB, Subramaniam S. Heme Oxygenase-1 at the Nexus of Endothelial Cell Fate Decision Under Oxidative Stress. Frontiers in Cell and Developmental Biology. 9: 702974. PMID 34595164 DOI: 10.3389/fcell.2021.702974  0.698
2020 Caldwell AB, Liu Q, Schroth GP, Galasko DR, Yuan SH, Wagner SL, Subramaniam S. Dedifferentiation and neuronal repression define familial Alzheimer's disease. Science Advances. 6. PMID 33188013 DOI: 10.1126/sciadv.aba5933  0.651
2020 Min J, Ningappa M, So J, Shin D, Sindhi R, Subramaniam S. Systems Analysis of Biliary Atresia Through Integration of High-Throughput Biological Data. Frontiers in Physiology. 11: 966. PMID 32848883 DOI: 10.3389/Fphys.2020.00966  0.31
2020 Masnadi-Shirazi M, Subramaniam S. Attractor Ranked Radial Basis Function Network: A Nonparametric Forecasting Approach for Chaotic Dynamic Systems. Scientific Reports. 10: 3780. PMID 32123218 DOI: 10.1038/S41598-020-60606-1  0.313
2019 Masnadi-Shirazi M, Maurya MR, Pao G, Ke E, Verma IM, Subramaniam S. Time varying causal network reconstruction of a mouse cell cycle. Bmc Bioinformatics. 20: 294. PMID 31142274 DOI: 10.1186/S12859-019-2895-1  0.722
2018 Subramaniam S, Caldwell A, Bhargava V, Friedman-Morvinski D, Lu Q, Yuan S, Galasko D, Verma I, Wagner S. Mechanisms Defining the Neuronal State Space Biophysical Journal. 114: 23a-24a. DOI: 10.1016/J.Bpj.2017.11.172  0.638
2017 Mukund K, Subramaniam S. Co-expression Network Approach Reveals Functional Similarities among Diseases Affecting Human Skeletal Muscle. Frontiers in Physiology. 8: 980. PMID 29249983 DOI: 10.3389/Fphys.2017.00980  0.316
2017 Mukund K, Ward SR, Lieber RL, Subramaniam S. Co-expression Network Approach to Studying the Effects of Botulinum Neurotoxin-A. Ieee/Acm Transactions On Computational Biology and Bioinformatics. 1. PMID 29053464 DOI: 10.1109/Tcbb.2017.2763949  0.325
2017 Huang TS, Wang KC, Quon S, Nguyen P, Chang TY, Chen Z, Li YS, Subramaniam S, Shyy JY, Chien S. LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1. Physiological Genomics. physiolgenomics.0013. PMID 28500253 DOI: 10.1152/Physiolgenomics.00132.2016  0.303
2017 Asadi B, Maurya MR, Tartakovsky DM, Subramaniam S. Doubly Penalized LASSO for Reconstruction of Biological Networks Proceedings of the Ieee. 105: 319-329. DOI: 10.1109/JPROC.2016.2535282  0.621
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Subramaniam S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.438
2015 Mukund K, Subramaniam S. Dysregulated mechanisms underlying Duchenne muscular dystrophy from co-expression network preservation analysis. Bmc Research Notes. 8: 182. PMID 25935398 DOI: 10.1186/S13104-015-1141-9  0.307
2014 Farhangmehr F, Maurya MR, Tartakovsky DM, Subramaniam S. Information theoretic approach to complex biological network reconstruction: application to cytokine release in RAW 264.7 macrophages. Bmc Systems Biology. 8: 77. PMID 24964861 DOI: 10.1186/1752-0509-8-77  0.335
2014 Masnadi-Shirazi M, Maurya MR, Subramaniam S. Time-varying causal inference from phosphoproteomic measurements in macrophage cells. Ieee Transactions On Biomedical Circuits and Systems. 8: 74-86. PMID 24681921 DOI: 10.1109/Tbcas.2013.2288035  0.356
2014 Gupta S, Kim SM, Wang Y, Dinasarapu AR, Subramaniam S. Statistical insights into major human muscular diseases. Human Molecular Genetics. 23: 3772-8. PMID 24569163 DOI: 10.1093/Hmg/Ddu090  0.31
2014 Kihara Y, Gupta S, Maurya MR, Armando A, Shah I, Quehenberger O, Glass CK, Dennis EA, Subramaniam S. Modeling of eicosanoid fluxes reveals functional coupling between cyclooxygenases and terminal synthases. Biophysical Journal. 106: 966-75. PMID 24559999 DOI: 10.1016/J.Bpj.2014.01.015  0.319
2014 Ramarathnam R, Subramaniam S. Phylogenomics of orthologous protein families in prokaryotes: Comparison of evolutionary profiles Current Bioinformatics. 9: 113-131. DOI: 10.2174/157489360902140313105531  0.765
2014 Friedmann-Morvinski D, Bhargava V, Gupta S, Verma IM, Subramaniam S. Abstract 1914: Functional characterization of oncogenic-induced dedifferentiation in neurons and astrocytes using DP-seq Cancer Research. 74: 1914-1914. DOI: 10.1158/1538-7445.Am2014-1914  0.306
2013 Mohammadi S, Subramaniam S, Grama A. Inferring the effective TOR-dependent network: a computational study in yeast. Bmc Systems Biology. 7: 84. PMID 24005029 DOI: 10.1186/1752-0509-7-84  0.348
2013 Narayanan T, Subramaniam S. Community Structure Analysis of Gene Interaction Networks in Duchenne Muscular Dystrophy. Plos One. 8: e67237. PMID 23840633 DOI: 10.1371/Journal.Pone.0067237  0.333
2013 Maurya MR, Gupta S, Li X, Fahy E, Dinasarapu AR, Sud M, Brown HA, Glass CK, Murphy RC, Russell DW, Dennis EA, Subramaniam S. Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages. Journal of Lipid Research. 54: 2525-42. PMID 23776196 DOI: 10.1194/Jlr.M040212  0.301
2013 Yang K, Dinasarapu AR, Reis ES, Deangelis RA, Ricklin D, Subramaniam S, Lambris JD. CMAP: Complement Map Database. Bioinformatics (Oxford, England). 29: 1832-3. PMID 23661693 DOI: 10.1093/Bioinformatics/Btt269  0.319
2012 Asadi B, Maurya MR, Tartakovsky DM, Subramaniam S. Comparison of statistical and optimisation-based methods for data-driven network reconstruction of biochemical systems. Iet Systems Biology. 6: 155-63. PMID 23101870 DOI: 10.1049/Iet-Syb.2011.0052  0.67
2012 Wang Y, Winters J, Subramaniam S. Functional classification of skeletal muscle networks. I. Normal physiology. Journal of Applied Physiology (Bethesda, Md. : 1985). 113: 1884-901. PMID 23085959 DOI: 10.1152/Japplphysiol.01514.2011  0.305
2012 Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, ... ... Subramaniam S, et al. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 151: 138-52. PMID 23021221 DOI: 10.1016/J.Cell.2012.06.054  0.3
2012 Towfic F, Gupta S, Honavar V, Subramaniam S. B-cell ligand processing pathways detected by large-scale comparative analysis. Genomics, Proteomics & Bioinformatics. 10: 142-52. PMID 22917187 DOI: 10.1016/J.Gpb.2012.03.001  0.336
2012 Subramaniam S, Hsiao G. Gene-expression measurement: variance-modeling considerations for robust data analysis. Nature Immunology. 13: 199-203. PMID 22344273 DOI: 10.1038/Ni.2244  0.571
2012 Asadi B, Tartakovsky DM, Maurya MR, Subramaniam S. Doubly penalized LASSO for reconstruction of biological networks Proceedings - 2012 Ieee 2nd Conference On Healthcare Informatics, Imaging and Systems Biology, Hisb 2012. 129. DOI: 10.1109/HISB.2012.54  0.648
2011 Narayanan T, Gersten M, Subramaniam S, Grama A. Modularity detection in protein-protein interaction networks. Bmc Research Notes. 4: 569. PMID 22206604 DOI: 10.1186/1756-0500-4-569  0.306
2011 Escoubet-Lozach L, Benner C, Kaikkonen MU, Lozach J, Heinz S, Spann NJ, Crotti A, Stender J, Ghisletti S, Reichart D, Cheng CS, Luna R, Ludka C, Sasik R, Garcia-Bassets I, ... ... Subramaniam S, et al. Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. Plos Genetics. 7: e1002401. PMID 22174696 DOI: 10.1371/Journal.Pgen.1002401  0.66
2011 Garmire LX, Garmire DG, Huang W, Yao J, Glass CK, Subramaniam S. A global clustering algorithm to identify long intergenic non-coding RNA--with applications in mouse macrophages. Plos One. 6: e24051. PMID 21980340 DOI: 10.1371/Journal.Pone.0024051  0.302
2011 Subramaniam S, Fahy E, Gupta S, Sud M, Byrnes RW, Cotter D, Dinasarapu AR, Maurya MR. Bioinformatics and systems biology of the lipidome. Chemical Reviews. 111: 6452-90. PMID 21939287 DOI: 10.1021/Cr200295K  0.311
2011 Fahy E, Cotter D, Sud M, Subramaniam S. Lipid classification, structures and tools. Biochimica Et Biophysica Acta. 1811: 637-47. PMID 21704189 DOI: 10.1016/J.Bbalip.2011.06.009  0.303
2011 Dinasarapu AR, Saunders B, Ozerlat I, Azam K, Subramaniam S. Signaling gateway molecule pages--a data model perspective. Bioinformatics (Oxford, England). 27: 1736-8. PMID 21505029 DOI: 10.1093/Bioinformatics/Btr190  0.304
2011 Subramaniam S, Nadeau JH. Pathways, networks, and systems medicine--the meeting place of the Aegean and the mind. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 3: 253-4. PMID 21462354 DOI: 10.1002/Wsbm.153  0.36
2011 Gupta S, Maurya MR, Merrill AH, Glass CK, Subramaniam S. Integration of lipidomics and transcriptomics data towards a systems biology model of sphingolipid metabolism. Bmc Systems Biology. 5: 26. PMID 21303545 DOI: 10.1186/1752-0509-5-26  0.336
2011 Hsiao G, Chapman J, Ofrecio JM, Wilkes J, Resnik JL, Thapar D, Subramaniam S, Sears DD. Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats. American Journal of Physiology. Endocrinology and Metabolism. 300: E164-74. PMID 20959535 DOI: 10.1152/Ajpendo.00219.2010  0.529
2010 Gupta S, Maurya MR, Subramaniam S. Identification of crosstalk between phosphoprotein signaling pathways in RAW 264.7 macrophage cells. Plos Computational Biology. 6: e1000654. PMID 20126526 DOI: 10.1371/Journal.Pcbi.1000654  0.318
2010 Andreyev AY, Shen Z, Guan Z, Ryan A, Fahy E, Subramaniam S, Raetz CR, Briggs S, Dennis EA. Application of proteomic marker ensembles to subcellular organelle identification. Molecular & Cellular Proteomics : McP. 9: 388-402. PMID 19884172 DOI: 10.1074/Mcp.M900432-Mcp200  0.309
2010 Asadi B, Tartakovsky DM, Maurya MR, Subramaniam S. Comparison of statistical and optimization-based methods for data-driven network reconstruction of biochemical systems Proceedings of the Iasted International Conference On Computational Bioscience, Compbio 2010. 587-592. DOI: 10.2316/P.2010.728-025  0.643
2009 Sears DD, Hsiao G, Hsiao A, Yu JG, Courtney CH, Ofrecio JM, Chapman J, Subramaniam S. Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. Proceedings of the National Academy of Sciences of the United States of America. 106: 18745-50. PMID 19841271 DOI: 10.1073/Pnas.0903032106  0.629
2009 Green CE, Liu T, Montel V, Hsiao G, Lester RD, Subramaniam S, Gonias SL, Klemke RL. Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. Plos One. 4: e6713. PMID 19696929 DOI: 10.1371/Journal.Pone.0006713  0.527
2009 Gupta S, Maurya MR, Stephens DL, Dennis EA, Subramaniam S. An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis. Biophysical Journal. 96: 4542-51. PMID 19486676 DOI: 10.1016/J.Bpj.2009.03.011  0.31
2009 Hill-Baskin AE, Markiewski MM, Buchner DA, Shao H, DeSantis D, Hsiao G, Subramaniam S, Berger NA, Croniger C, Lambris JD, Nadeau JH. Diet-induced hepatocellular carcinoma in genetically predisposed mice. Human Molecular Genetics. 18: 2975-88. PMID 19454484 DOI: 10.1093/Hmg/Ddp236  0.509
2009 Maurya MR, Bornheimer SJ, Venkatasubramanian V, Subramaniam S. Mixed-integer nonlinear optimisation approach to coarse-graining biochemical networks. Iet Systems Biology. 3: 24-39. PMID 19154082 DOI: 10.1049/Iet-Syb:20080098  0.74
2008 Hsiao A, Subramaniam S. Bivariate microarray analysis: statistical interpretation of two-channel functional genomics data. Systems and Synthetic Biology. 2: 95-104. PMID 19680790 DOI: 10.1007/S11693-009-9033-8  0.562
2008 Walsh CT, Radeff-Huang J, Matteo R, Hsiao A, Subramaniam S, Stupack D, Brown JH. Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 4011-21. PMID 18687805 DOI: 10.1096/Fj.08-113266  0.541
2007 Maurya MR, Benner C, Pradervand S, Glass C, Subramaniam S. Systems biology of macrophages. Advances in Experimental Medicine and Biology. 598: 62-79. PMID 17892205 DOI: 10.1007/978-0-387-71767-8_6  0.612
2007 Pandey J, Koyutürk M, Kim Y, Szpankowski W, Subramaniam S, Grama A. Functional annotation of regulatory pathways. Bioinformatics (Oxford, England). 23: i377-86. PMID 17646320 DOI: 10.1093/bioinformatics/btm203  0.486
2007 Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, Leung HY, Watt MJ, Benner C, Febbraio MA, Nguyen AK, Folian B, Subramaniam S, Gonzalez FJ, Glass CK, Ricote M. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. The Journal of Clinical Investigation. 117: 1658-69. PMID 17525798 DOI: 10.1172/Jci31561  0.54
2007 Zavzavadjian JR, Couture S, Park WS, Whalen J, Lyon S, Lee G, Fung E, Mi Q, Liu J, Wall E, Santat L, Dhandapani K, Kivork C, Driver A, Zhu X, ... ... Subramaniam S, et al. The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis. Molecular & Cellular Proteomics : McP. 6: 413-24. PMID 17192258 DOI: 10.1074/Mcp.M600437-Mcp200  0.329
2006 Koyutürk M, Kim Y, Subramaniam S, Szpankowski W, Grama A. Detecting conserved interaction patterns in biological networks. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 13: 1299-322. PMID 17037960 DOI: 10.1089/Cmb.2006.13.1299  0.507
2006 Koyutürk M, Kim Y, Topkara U, Subramaniam S, Szpankowski W, Grama A. Pairwise alignment of protein interaction networks. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 13: 182-99. PMID 16597234 DOI: 10.1089/Cmb.2006.13.182  0.527
2006 Raetz CR, Garrett TA, Reynolds CM, Shaw WA, Moore JD, Smith DC, Ribeiro AA, Murphy RC, Ulevitch RJ, Fearns C, Reichart D, Glass CK, Benner C, Subramaniam S, Harkewicz R, et al. Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. Journal of Lipid Research. 47: 1097-111. PMID 16479018 DOI: 10.1194/Jlr.M600027-Jlr200  0.56
2006 Kim Y, Subramaniam S. Locally defined protein phylogenetic profiles reveal previously missed protein interactions and functional relationships. Proteins. 62: 1115-24. PMID 16385560 DOI: 10.1002/Prot.20830  0.52
2006 Kim Y, Koyutürk M, Topkara U, Grama A, Subramaniam S. Inferring functional information from domain co-evolution. Bioinformatics (Oxford, England). 22: 40-9. PMID 16301205 DOI: 10.1093/Bioinformatics/Bti723  0.499
2005 Maurya MR, Bornheimer SJ, Venkatasubramanian V, Subramaniam S. Reduced-order modelling of biochemical networks: application to the GTPase-cycle signalling module. Systems Biology. 152: 229-42. PMID 16986265 DOI: 10.1049/ip-syb:20050014  0.73
2005 Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass CK. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 122: 707-21. PMID 16143103 DOI: 10.1016/J.Cell.2005.06.029  0.653
2005 Hsiao A, Ideker T, Olefsky JM, Subramaniam S. VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data. Nucleic Acids Research. 33: W627-32. PMID 15980550 DOI: 10.1093/Nar/Gki443  0.56
2004 Zhu X, Hart R, Chang MS, Kim JW, Lee SY, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Lin KM, Yan Z, Hsueh R, Lee J, ... ... Subramaniam S, et al. Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. Journal of Immunology (Baltimore, Md. : 1950). 173: 7141-9. PMID 15585835 DOI: 10.4049/Jimmunol.173.12.7141  0.715
2004 Bornheimer SJ, Maurya MR, Farquhar MG, Subramaniam S. Computational modeling reveals how interplay between components of a GTPase-cycle module regulates signal transduction. Proceedings of the National Academy of Sciences of the United States of America. 101: 15899-904. PMID 15520372 DOI: 10.1073/Pnas.0407009101  0.759
2004 Hsiao A, Worrall DS, Olefsky JM, Subramaniam S. Variance-modeled posterior inference of microarray data: detecting gene-expression changes in 3T3-L1 adipocytes. Bioinformatics (Oxford, England). 20: 3108-27. PMID 15217816 DOI: 10.1093/Bioinformatics/Bth371  0.561
2004 Avidor-Reiss T, Maer AM, Koundakjian E, Polyanovsky A, Keil T, Subramaniam S, Zuker CS. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Cell. 117: 527-39. PMID 15137945 DOI: 10.1016/S0092-8674(04)00412-X  0.318
2004 Papin J, Subramaniam S. Bioinformatics and cellular signaling Current Opinion in Biotechnology. 15: 78-81. PMID 15102471 DOI: 10.1016/J.Copbio.2004.01.003  0.327
2004 Cotter D, Guda P, Fahy E, Subramaniam S. MitoProteome: mitochondrial protein sequence database and annotation system. Nucleic Acids Research. 32: D463-7. PMID 14681458 DOI: 10.1093/Nar/Gkh048  0.304
2003 Shealy RT, Murphy AD, Ramarathnam R, Jakobsson E, Subramaniam S. Sequence-function analysis of the K+-selective family of ion channels using a comprehensive alignment and the KcsA channel structure. Biophysical Journal. 84: 2929-42. PMID 12719225 DOI: 10.1016/S0006-3495(03)70020-4  0.748
2003 Subramaniam S. Bioinformatics of cellular signalling. Novartis Foundation Symposium. 247: 104-16; discussion 1. PMID 12539952 DOI: 10.1002/0470857897.Ch9  0.341
2000 Ramarathnam R, Subramaniam S. A novel microarray strategy for detecting genes and pathways in microbes with unsequenced genomes. Microbial & Comparative Genomics. 5: 153-61. PMID 11252352 DOI: 10.1089/Omi.1.2000.5.153  0.769
1996 Singh C, Sankararamakrishnan R, Subramaniam S, Jakobsson E. Solvation, water permeation, and ionic selectivity of a putative model for the pore region of the voltage-gated sodium channel. Biophysical Journal. 71: 2276-88. PMID 8913570 DOI: 10.1016/S0006-3495(96)79438-9  0.616
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