| Year |
Citation |
Score |
| 2023 |
Motallebnejad P, Kantardjieff A, Cichocki F, Azarin SM, Hu WS. Process engineering of natural killer cell-based immunotherapy. Trends in Biotechnology. PMID 37142447 DOI: 10.1016/j.tibtech.2023.03.018 |
0.764 |
|
| 2022 |
Lee Z, Lu M, Irfanullah E, Soukup M, Hu WS. Construction of an rAAV Producer Cell Line through Synthetic Biology. Acs Synthetic Biology. PMID 36219557 DOI: 10.1021/acssynbio.2c00207 |
0.318 |
|
| 2021 |
O'Brien CM, Zhang Q, Daoutidis P, Hu WS. A hybrid mechanistic-empirical model for in silico mammalian cell bioprocess simulation. Metabolic Engineering. PMID 33813033 DOI: 10.1016/j.ymben.2021.03.016 |
0.569 |
|
| 2021 |
Lee Z, Raabe M, Hu WS. Epigenomic features revealed by ATAC-seq impact transgene expression in CHO cells. Biotechnology and Bioengineering. PMID 33521928 DOI: 10.1002/bit.27701 |
0.3 |
|
| 2020 |
O'Brien SA, Hu WS. Cell culture bioprocessing - the road taken and the path forward. Current Opinion in Chemical Engineering. 30. PMID 33391982 DOI: 10.1016/j.coche.2020.100663 |
0.312 |
|
| 2020 |
O'Brien CM, Mulukutla BC, Mashek DG, Hu WS. Regulation of Metabolic Homeostasis in Cell Culture Bioprocesses. Trends in Biotechnology. 38: 1113-1127. PMID 32941791 DOI: 10.1016/J.Tibtech.2020.02.005 |
0.794 |
|
| 2020 |
Erickson RJB, Bandyopadhyay AA, Barnes AMT, O'Brien SA, Hu WS, Dunny GM. Single-Cell Analysis Reveals that the Enterococcal Sex Pheromone Response Results in Expression of Full-length Conjugation Operon Transcripts in All Induced Cells. Journal of Bacteriology. PMID 32041799 DOI: 10.1128/Jb.00685-19 |
0.399 |
|
| 2020 |
O'Brien SA, Ojha J, Wu P, Hu WS. Multiplexed clonality verification of cell lines for protein biologic production. Biotechnology Progress. e2978. PMID 32034880 DOI: 10.1002/Btpr.2978 |
0.394 |
|
| 2019 |
Stach C, McCann M, O'Brien C, Le TS, Somia N, Chen X, Lee K, Fu HY, Daoutidis P, Zhao L, Hu WS, Smanski MJ. Model-driven engineering of N-linked glycosylation in Chinese Hamster Ovary cells. Acs Synthetic Biology. PMID 31596566 DOI: 10.1021/Acssynbio.9B00215 |
0.55 |
|
| 2019 |
O'Brien C, Allman A, Daoutidis P, Hu WS. Kinetic model optimization and its application to mitigating the Warburg effect through multiple enzyme alterations. Metabolic Engineering. PMID 31400493 DOI: 10.1016/J.Ymben.2019.08.005 |
0.578 |
|
| 2019 |
Le T, O'Brien C, Gupta U, Sousa G, Daoutidis P, Hu WS. An integrated platform for mucin-type o-glycosylation network generation and visualization. Biotechnology and Bioengineering. PMID 30739313 DOI: 10.1002/Bit.26952 |
0.541 |
|
| 2019 |
O'Brien SA, Ojha J, Wu P, Hu W. Author response for "Multiplexed clonality verification of cell lines for protein biologic production" Biotechnology Progress. DOI: 10.1002/Btpr.2978/V2/Response1 |
0.37 |
|
| 2018 |
Bandyopadhyay AA, O'Brien SA, Zhao L, Fu HY, Vishwanathan N, Hu WS. Recurring Genomic Structural Variation Leads to Clonal Instability and Loss of Productivity. Biotechnology and Bioengineering. PMID 30144379 DOI: 10.1002/Bit.26823 |
0.746 |
|
| 2018 |
Gupta U, Le T, Hu WS, Bhan A, Daoutidis P. Automated Network Generation and Analysis of Biochemical Reaction Pathways Using RING. Metabolic Engineering. PMID 30031851 DOI: 10.1016/J.Ymben.2018.07.009 |
0.52 |
|
| 2018 |
O'Brien SA, Lee K, Fu HY, Lee Z, Le TS, Stach CS, McCann MG, Zhang AQ, Smanski MJ, Somia NV, Hu WS. Single Copy Transgene Integration in a Transcriptionally Active Site for Recombinant Protein Synthesis. Biotechnology Journal. e1800226. PMID 30024101 DOI: 10.1002/Biot.201800226 |
0.308 |
|
| 2017 |
Pei H, Fu HY, Hirai H, Cho DS, O'Brien TD, Dutton J, Verfaillie CM, Hu WS. Generation of induced pluripotent stem cells from Chinese hamster embryonic fibroblasts. Stem Cell Research. 21: 132-136. PMID 28677528 DOI: 10.1016/J.Scr.2017.04.010 |
0.368 |
|
| 2017 |
Breuer RJ, Bandyopadhyay A, O'Brien SA, Barnes AMT, Hunter RC, Hu WS, Dunny GM. Stochasticity in the enterococcal sex pheromone response revealed by quantitative analysis of transcription in single cells. Plos Genetics. 13: e1006878. PMID 28671948 DOI: 10.1371/Journal.Pgen.1006878 |
0.413 |
|
| 2017 |
Yusufi FNK, Lakshmanan M, Ho YS, Loo BLW, Ariyaratne P, Yang Y, Ng SK, Tan TRM, Yeo HC, Lim HL, Ng SW, Hiu AP, Chow CP, Wan C, Chen S, ... ... Hu WS, et al. Mammalian Systems Biotechnology Reveals Global Cellular Adaptations in a Recombinant CHO Cell Line. Cell Systems. 4: 530-542.e6. PMID 28544881 DOI: 10.1016/J.Cels.2017.04.009 |
0.336 |
|
| 2017 |
Vishwanathan N, Bandyopadhyay A, Fu HY, Johnson KC, Springer NM, Hu WS. A COMPARATIVE GENOMIC HYBRIDIZATION APPROACH TO STUDY GENE COPY NUMBER VARIATIONS AMONG CHINESE HAMSTER CELL LINES. Biotechnology and Bioengineering. PMID 28409824 DOI: 10.1002/Bit.26311 |
0.731 |
|
| 2017 |
Zhao L, Fu HY, Raju R, Vishwanathan N, Hu WS. Unveiling gene trait relationship by cross-platform meta-analysis on Chinese hamster ovary cell transcriptome. Biotechnology and Bioengineering. PMID 28218403 DOI: 10.1002/Bit.26272 |
0.741 |
|
| 2016 |
Vishwanathan N, Bandyopadhyay AA, Fu HY, Sharma M, Johnson KC, Mudge J, Ramaraj T, Onsongo G, Silverstein KA, Jacob NM, Le H, Karypis G, Hu WS. Augmenting Chinese hamster genome assembly by identifying regions of high confidence. Biotechnology Journal. PMID 27374913 DOI: 10.1002/Biot.201500455 |
0.803 |
|
| 2016 |
Mulukutla BC, Yongky A, Le T, Mashek DG, Hu WS. Regulation of Glucose Metabolism - A Perspective From Cell Bioprocessing. Trends in Biotechnology. PMID 27265890 DOI: 10.1016/J.Tibtech.2016.04.012 |
0.811 |
|
| 2015 |
Le H, Vishwanathan N, Jacob NM, Gadgil M, Hu WS. Cell line development for biomanufacturing processes: recent advances and an outlook. Biotechnology Letters. 37: 1553-64. PMID 25971160 DOI: 10.1007/S10529-015-1843-Z |
0.81 |
|
| 2015 |
Mulukutla BC, Yongky A, Grimm S, Daoutidis P, Hu WS. Multiplicity of steady states in glycolysis and shift of metabolic state in cultured mammalian cells. Plos One. 10: e0121561. PMID 25806512 DOI: 10.1371/Journal.Pone.0121561 |
0.809 |
|
| 2015 |
Yongky A, Lee J, Le T, Mulukutla BC, Daoutidis P, Hu WS. Mechanism for multiplicity of steady states with distinct cell concentration in continuous culture of mammalian cells. Biotechnology and Bioengineering. 112: 1437-45. PMID 25676211 DOI: 10.1002/Bit.25566 |
0.807 |
|
| 2015 |
Vishwanathan N, Yongky A, Johnson KC, Fu HY, Jacob NM, Le H, Yusufi FN, Lee DY, Hu WS. Global insights into the Chinese hamster and CHO cell transcriptomes. Biotechnology and Bioengineering. 112: 965-76. PMID 25450749 DOI: 10.1002/Bit.25513 |
0.824 |
|
| 2014 |
Vishwanathan N, Le H, Le T, Hu WS. Advancing biopharmaceutical process science through transcriptome analysis. Current Opinion in Biotechnology. 30: 113-9. PMID 25014889 DOI: 10.1016/J.Copbio.2014.06.011 |
0.793 |
|
| 2014 |
Mulukutla BC, Yongky A, Daoutidis P, Hu WS. Bistability in glycolysis pathway as a physiological switch in energy metabolism. Plos One. 9: e98756. PMID 24911170 DOI: 10.1371/Journal.Pone.0098756 |
0.787 |
|
| 2014 |
Johnson KC, Yongky A, Vishwanathan N, Jacob NM, Jayapal KP, Goudar CT, Karypis G, Hu WS. Exploring the transcriptome space of a recombinant BHK cell line through next generation sequencing. Biotechnology and Bioengineering. 111: 770-81. PMID 24249083 DOI: 10.1002/Bit.25135 |
0.812 |
|
| 2014 |
Vishwanathan N, Le H, Jacob NM, Tsao YS, Ng SW, Loo B, Liu Z, Kantardjieff A, Hu WS. Transcriptome dynamics of transgene amplification in Chinese hamster ovary cells. Biotechnology and Bioengineering. 111: 518-28. PMID 24108600 DOI: 10.1002/Bit.25117 |
0.823 |
|
| 2013 |
Shu CC, Chatterjee A, Hu WS, Ramkrishna D. Role of intracellular stochasticity in biofilm growth. Insights from population balance modeling. Plos One. 8: e79196. PMID 24232571 DOI: 10.1371/Journal.Pone.0079196 |
0.633 |
|
| 2013 |
Rodrigues AF, Formas-Oliveira AS, Bandeira VS, Alves PM, Hu WS, Coroadinha AS. Metabolic pathways recruited in the production of a recombinant enveloped virus: Mining targets for process and cell engineering Metabolic Engineering. 20: 131-145. PMID 24120735 DOI: 10.1016/J.Ymben.2013.10.001 |
0.429 |
|
| 2013 |
Le H, Vishwanathan N, Kantardjieff A, Doo I, Srienc M, Zheng X, Somia N, Hu WS. Dynamic gene expression for metabolic engineering of mammalian cells in culture. Metabolic Engineering. 20: 212-20. PMID 24055788 DOI: 10.1016/J.Ymben.2013.09.004 |
0.828 |
|
| 2013 |
Chatterjee A, Cook LC, Shu CC, Chen Y, Manias DA, Ramkrishna D, Dunny GM, Hu WS. Antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer. Proceedings of the National Academy of Sciences of the United States of America. 110: 7086-90. PMID 23569272 DOI: 10.1073/Pnas.1212256110 |
0.591 |
|
| 2012 |
Le H, Kabbur S, Pollastrini L, Sun Z, Mills K, Johnson K, Karypis G, Hu WS. Multivariate analysis of cell culture bioprocess data--lactate consumption as process indicator. Journal of Biotechnology. 162: 210-23. PMID 22974585 DOI: 10.1016/J.Jbiotec.2012.08.021 |
0.554 |
|
| 2012 |
Clark DS, Blanch HW, Wang DI, Demain AL, Wandrey C, Hu WS, Schultz JS, Shuler ML, Hoare M, Lightfoot EN, Humphrey AE, Dordick JS, Asenjo JA. Elmer L. Gaden, Jr. Tribute. Biotechnology and Bioengineering. 109: 2417-21. PMID 22910882 DOI: 10.1002/Bit.24610 |
0.6 |
|
| 2012 |
Lo Nigro A, Geraerts M, Notelaers T, Roobrouck VD, Muijtjens M, Eggermont K, Subramanian K, Ulloa-Montoya F, Park Y, Owens J, Burns TC, Low W, Sharma S, Sohni A, Crabbe A, ... ... Hu WS, et al. MAPC culture conditions support the derivation of cells with nascent hypoblast features from bone marrow and blastocysts. Journal of Molecular Cell Biology. 4: 423-6. PMID 22878264 DOI: 10.1093/Jmcb/Mjs046 |
0.43 |
|
| 2012 |
Shu CC, Chatterjee A, Hu WS, Ramkrishna D. MODELING OF GENE REGULATORY PROCESSES BY POPULATION MEDIATED SIGNALING. NEW APPLICATIONS OF POPULATION BALANCES. Chemical Engineering Science. 70: 188-199. PMID 22581980 DOI: 10.1016/J.Ces.2011.07.062 |
0.626 |
|
| 2012 |
Zhou W, Rehm J, Europa A, Hu WS. Alteration of mammalian cell metabolism by dynamic nutrient feeding. Cytotechnology. 24: 99-108. PMID 22358650 DOI: 10.1023/A:1007945826228 |
0.814 |
|
| 2012 |
Kim JH, Hu WS. Initial culture conditions affect the sensitivity of HepG2 cells to excessive mechanical agitation. Cytotechnology. 2: 135-40. PMID 22358626 DOI: 10.1007/Bf00386146 |
0.382 |
|
| 2012 |
Mulukutla BC, Gramer M, Hu WS. On metabolic shift to lactate consumption in fed-batch culture of mammalian cells. Metabolic Engineering. 14: 138-49. PMID 22244936 DOI: 10.1016/J.Ymben.2011.12.006 |
0.788 |
|
| 2012 |
Castro-Melchor M, Le H, Hu WS. Transcriptome data analysis for cell culture processes. Advances in Biochemical Engineering/Biotechnology. 127: 27-70. PMID 22194060 DOI: 10.1007/10_2011_116 |
0.809 |
|
| 2012 |
Hu WS, Meier J, Wang DI. A mechanistic analysis of the inoculum requirement for the cultivation of mammalian cells on microcarriers. Biotechnology and Bioengineering. 27: 585-95. PMID 18553713 DOI: 10.1002/Bit.260270507 |
0.592 |
|
| 2012 |
Shu CC, Chatterjee A, Hu WS, Ramkrishna D. Modeling of gene regulatory processes by population-mediated signaling: New applications of population balances Chemical Engineering Science. 70: 188-199. DOI: 10.1016/j.ces.2011.07.062 |
0.595 |
|
| 2011 |
Szperalski B, Jung C, Shao Z, Kantardjieff A, Hu WS. LDH-C can be differentially expressed during fermentation of CHO cells. Bmc Proceedings. 5: P107. PMID 22373157 DOI: 10.1186/1753-6561-5-S8-P107 |
0.796 |
|
| 2011 |
Le H, Castro-Melchor M, Hakemeyer C, Jung C, Szperalski B, Karypis G, Hu WS. Discerning key parameters influencing high productivity and quality through recognition of patterns in process data. Bmc Proceedings. 5: P91. PMID 22373092 DOI: 10.1186/1753-6561-5-S8-P91 |
0.782 |
|
| 2011 |
Shu CC, Chatterjee A, Dunny G, Hu WS, Ramkrishna D. Bistability versus bimodal distributions in gene regulatory processes from population balance Plos Computational Biology. 7. PMID 21901083 DOI: 10.1371/Journal.Pcbi.1002140 |
0.671 |
|
| 2011 |
Cook L, Chatterjee A, Barnes A, Yarwood J, Hu WS, Dunny G. Biofilm growth alters regulation of conjugation by a bacterial pheromone. Molecular Microbiology. 81: 1499-510. PMID 21843206 DOI: 10.1111/J.1365-2958.2011.07786.X |
0.647 |
|
| 2011 |
Chatterjee A, Drews L, Mehra S, Takano E, Kaznessis YN, Hu WS. Convergent transcription in the butyrolactone regulon in Streptomyces coelicolor confers a bistable genetic switch for antibiotic biosynthesis. Plos One. 6: e21974. PMID 21765930 DOI: 10.1371/Journal.Pone.0021974 |
0.713 |
|
| 2011 |
Sharma S, Raju R, Sui S, Hu WS. Stem cell culture engineering - process scale up and beyond. Biotechnology Journal. 6: 1317-29. PMID 21721127 DOI: 10.1002/Biot.201000435 |
0.653 |
|
| 2011 |
Ruffing AM, Castro-Melchor M, Hu WS, Chen RR. Genome sequence of the curdlan-producing Agrobacterium sp. strain ATCC 31749. Journal of Bacteriology. 193: 4294-5. PMID 21685288 DOI: 10.1128/Jb.05302-11 |
0.776 |
|
| 2011 |
Chatterjee A, Johnson CM, Shu CC, Kaznessis YN, Ramkrishna D, Dunny GM, Hu WS. Convergent transcription confers a bistable switch in Enterococcus faecalis conjugation Proceedings of the National Academy of Sciences of the United States of America. 108: 9721-9726. PMID 21606359 DOI: 10.1073/Pnas.1101569108 |
0.636 |
|
| 2011 |
Johnson KC, Jacob NM, Nissom PM, Hackl M, Lee LH, Yap M, Hu WS. Conserved microRNAs in Chinese hamster ovary cell lines. Biotechnology and Bioengineering. 108: 475-80. PMID 20830683 DOI: 10.1002/Bit.22940 |
0.715 |
|
| 2011 |
Subramanian K, Park Y, Verfaillie CM, Hu WS. Scalable expansion of multipotent adult progenitor cells as three-dimensional cell aggregates. Biotechnology and Bioengineering. 108: 364-75. PMID 20830682 DOI: 10.1002/Bit.22939 |
0.382 |
|
| 2011 |
Shu C, Chatterjee A, Dunny G, Hu W, Ramkrishna D. Correction: Bistability versus Bimodal Distributions in Gene Regulatory Processes from Population Balance Plos Computational Biology. 7. DOI: 10.1371/Annotation/9C1B51D2-1957-43Ff-81Bc-Da833Eda0B8C |
0.625 |
|
| 2010 |
Deshpande R, Sharma S, Verfaillie CM, Hu WS, Myers CL. A scalable approach for discovering conserved active subnetworks across species. Plos Computational Biology. 6: e1001028. PMID 21170309 DOI: 10.1371/Journal.Pcbi.1001028 |
0.48 |
|
| 2010 |
Castro-Melchor M, Charaniya S, Karypis G, Takano E, Hu WS. Genome-wide inference of regulatory networks in Streptomyces coelicolor. Bmc Genomics. 11: 578. PMID 20955611 DOI: 10.1186/1471-2164-11-578 |
0.79 |
|
| 2010 |
Park Y, Subramanian K, Verfaillie CM, Hu WS. Expansion and hepatic differentiation of rat multipotent adult progenitor cells in microcarrier suspension culture. Journal of Biotechnology. 150: 131-9. PMID 20696191 DOI: 10.1016/J.Jbiotec.2010.08.001 |
0.404 |
|
| 2010 |
Mulukutla BC, Khan S, Lange A, Hu WS. Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways. Trends in Biotechnology. 28: 476-84. PMID 20691487 DOI: 10.1016/J.Tibtech.2010.06.005 |
0.805 |
|
| 2010 |
Yee JC, Jacob NM, Jayapal KP, Kok YJ, Philp R, Griffin TJ, Hu WS. Global assessment of protein turnover in recombinant antibody producing myeloma cells. Journal of Biotechnology. 148: 182-93. PMID 20540971 DOI: 10.1016/J.Jbiotec.2010.06.005 |
0.787 |
|
| 2010 |
Charaniya S, Le H, Rangwala H, Mills K, Johnson K, Karypis G, Hu WS. Mining manufacturing data for discovery of high productivity process characteristics. Journal of Biotechnology. 147: 186-97. PMID 20416347 DOI: 10.1016/J.Jbiotec.2010.04.005 |
0.8 |
|
| 2010 |
Jayapal KP, Sui S, Philp RJ, Kok YJ, Yap MG, Griffin TJ, Hu WS. Multitagging proteomic strategy to estimate protein turnover rates in dynamic systems. Journal of Proteome Research. 9: 2087-97. PMID 20184388 DOI: 10.1021/Pr9007738 |
0.785 |
|
| 2010 |
Jacob NM, Kantardjieff A, Yusufi FN, Retzel EF, Mulukutla BC, Chuah SH, Yap M, Hu WS. Reaching the depth of the Chinese hamster ovary cell transcriptome. Biotechnology and Bioengineering. 105: 1002-9. PMID 19882695 DOI: 10.1002/Bit.22588 |
0.796 |
|
| 2010 |
Kantardjieff A, Jacob NM, Yee JC, Epstein E, Kok YJ, Philp R, Betenbaugh M, Hu WS. Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment. Journal of Biotechnology. 145: 143-59. PMID 19770009 DOI: 10.1016/J.Jbiotec.2009.09.008 |
0.814 |
|
| 2009 |
Kantardjieff A, Nissom PM, Chuah SH, Yusufi F, Jacob NM, Mulukutla BC, Yap M, Hu WS. Developing genomic platforms for Chinese hamster ovary cells. Biotechnology Advances. 27: 1028-35. PMID 19470403 DOI: 10.1016/J.Biotechadv.2009.05.023 |
0.804 |
|
| 2009 |
Charaniya S, Karypis G, Hu WS. Mining transcriptome data for function-trait relationship of hyper productivity of recombinant antibody. Biotechnology and Bioengineering. 102: 1654-69. PMID 19132744 DOI: 10.1002/Bit.22210 |
0.812 |
|
| 2009 |
Yee JC, Gerdtzen ZP, Hu WS. Comparative transcriptome analysis to unveil genes affecting recombinant protein productivity in mammalian cells. Biotechnology and Bioengineering. 102: 246-63. PMID 18726962 DOI: 10.1002/Bit.22039 |
0.678 |
|
| 2008 |
Charaniya S, Hu WS, Karypis G. Mining bioprocess data: opportunities and challenges. Trends in Biotechnology. 26: 690-9. PMID 18977046 DOI: 10.1016/J.Tibtech.2008.09.003 |
0.759 |
|
| 2008 |
Yee JC, Wlaschin KF, Chuah SH, Nissom PM, Hu WS. Quality assessment of cross-species hybridization of CHO transcriptome on a mouse DNA oligo microarray. Biotechnology and Bioengineering. 101: 1359-65. PMID 18814282 DOI: 10.1002/Bit.21984 |
0.8 |
|
| 2008 |
Chatterjee A, Kaznessis YN, Hu WS. Tweaking biological switches through a better understanding of bistability behavior. Current Opinion in Biotechnology. 19: 475-81. PMID 18804166 DOI: 10.1016/J.Copbio.2008.08.010 |
0.584 |
|
| 2008 |
Mehra S, Charaniya S, Takano E, Hu WS. A bistable gene switch for antibiotic biosynthesis: the butyrolactone regulon in Streptomyces coelicolor. Plos One. 3: e2724. PMID 18628968 DOI: 10.1371/Journal.Pone.0002724 |
0.802 |
|
| 2008 |
Cameron CM, Harding F, Hu WS, Kaufman DS. Activation of hypoxic response in human embryonic stem cell-derived embryoid bodies. Experimental Biology and Medicine (Maywood, N.J.). 233: 1044-57. PMID 18535160 DOI: 10.3181/0709-RM-263 |
0.527 |
|
| 2008 |
Jayapal KP, Philp RJ, Kok YJ, Yap MG, Sherman DH, Griffin TJ, Hu WS. Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. Plos One. 3: e2097. PMID 18461186 DOI: 10.1371/Journal.Pone.0002097 |
0.798 |
|
| 2008 |
Lian W, Jayapal KP, Charaniya S, Mehra S, Glod F, Kyung YS, Sherman DH, Hu WS. Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2). Bmc Genomics. 9: 56. PMID 18230178 DOI: 10.1186/1471-2164-9-56 |
0.799 |
|
| 2008 |
Yee JC, de Leon Gatti M, Philp RJ, Yap M, Hu WS. Genomic and proteomic exploration of CHO and hybridoma cells under sodium butyrate treatment. Biotechnology and Bioengineering. 99: 1186-204. PMID 17929327 DOI: 10.1002/Bit.21665 |
0.82 |
|
| 2008 |
Hu W. KN-019Toward genomic cell culture engineering via physiological fundamentals Journal of Biotechnology. 136. DOI: 10.1016/J.Jbiotec.2008.07.369 |
0.374 |
|
| 2007 |
Seth G, Charaniya S, Wlaschin KF, Hu WS. In pursuit of a super producer-alternative paths to high producing recombinant mammalian cells. Current Opinion in Biotechnology. 18: 557-64. PMID 18082393 DOI: 10.1016/J.Copbio.2007.10.012 |
0.821 |
|
| 2007 |
Charaniya S, Mehra S, Lian W, Jayapal KP, Karypis G, Hu WS. Transcriptome dynamics-based operon prediction and verification in Streptomyces coelicolor. Nucleic Acids Research. 35: 7222-36. PMID 17959654 DOI: 10.1093/Nar/Gkm501 |
0.799 |
|
| 2007 |
Hossler P, Mulukutla BC, Hu WS. Systems analysis of N-glycan processing in mammalian cells. Plos One. 2: e713. PMID 17684559 DOI: 10.1371/Journal.Pone.0000713 |
0.789 |
|
| 2007 |
Griffin TJ, Seth G, Xie H, Bandhakavi S, Hu WS. Advancing mammalian cell culture engineering using genome-scale technologies. Trends in Biotechnology. 25: 401-8. PMID 17681628 DOI: 10.1016/J.Tibtech.2007.07.004 |
0.644 |
|
| 2007 |
Wlaschin KF, Hu WS. Engineering cell metabolism for high-density cell culture via manipulation of sugar transport. Journal of Biotechnology. 131: 168-76. PMID 17662499 DOI: 10.1016/J.Jbiotec.2007.06.006 |
0.814 |
|
| 2007 |
Jayapal KP, Lian W, Glod F, Sherman DH, Hu WS. Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans. Bmc Genomics. 8: 229. PMID 17623098 DOI: 10.1186/1471-2164-8-229 |
0.8 |
|
| 2007 |
Wlaschin KF, Hu WS. A scaffold for the Chinese hamster genome. Biotechnology and Bioengineering. 98: 429-39. PMID 17390381 DOI: 10.1002/Bit.21430 |
0.804 |
|
| 2007 |
De Leon Gatti M, Wlaschin KF, Nissom PM, Yap M, Hu WS. Comparative transcriptional analysis of mouse hybridoma and recombinant Chinese hamster ovary cells undergoing butyrate treatment. Journal of Bioscience and Bioengineering. 103: 82-91. PMID 17298905 DOI: 10.1263/Jbb.103.82 |
0.811 |
|
| 2007 |
Seth G, Philp RJ, Lau A, Jiun KY, Yap M, Hu WS. Molecular portrait of high productivity in recombinant NS0 cells. Biotechnology and Bioengineering. 97: 933-51. PMID 17149768 DOI: 10.1002/Bit.21234 |
0.697 |
|
| 2006 |
Wlaschin KF, Seth G, Hu WS. Toward genomic cell culture engineering. Cytotechnology. 50: 121-40. PMID 19003075 DOI: 10.1007/S10616-006-9004-9 |
0.825 |
|
| 2006 |
Nissom PM, Sanny A, Kok YJ, Hiang YT, Chuah SH, Shing TK, Lee YY, Wong KT, Hu WS, Sim MY, Philp R. Transcriptome and proteome profiling to understanding the biology of high productivity CHO cells. Molecular Biotechnology. 34: 125-40. PMID 17172658 |
0.308 |
|
| 2006 |
Seth G, Hossler P, Yee JC, Hu WS. Engineering cells for cell culture bioprocessing--physiological fundamentals. Advances in Biochemical Engineering/Biotechnology. 101: 119-64. PMID 16989260 DOI: 10.1007/10_017 |
0.812 |
|
| 2006 |
Wlaschin KF, Hu WS. Fedbatch culture and dynamic nutrient feeding. Advances in Biochemical Engineering/Biotechnology. 101: 43-74. PMID 16989257 DOI: 10.1007/10_015 |
0.815 |
|
| 2006 |
Hossler P, Goh LT, Lee MM, Hu WS. GlycoVis: visualizing glycan distribution in the protein N-glycosylation pathway in mammalian cells. Biotechnology and Bioengineering. 95: 946-60. PMID 16807922 DOI: 10.1002/Bit.21062 |
0.792 |
|
| 2006 |
Cameron CM, Hu WS, Kaufman DS. Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivation. Biotechnology and Bioengineering. 94: 938-48. PMID 16547998 DOI: 10.1002/bit.20919 |
0.564 |
|
| 2006 |
Gadgil M, Mehra S, Kapur V, Hu WS. TimeView: for comparative gene expression analysis. Applied Bioinformatics. 5: 41-4. PMID 16539536 DOI: 10.2165/00822942-200605010-00005 |
0.661 |
|
| 2006 |
Mehra S, Lian W, Jayapal KP, Charaniya SP, Sherman DH, Hu WS. A framework to analyze multiple time series data: a case study with Streptomyces coelicolor. Journal of Industrial Microbiology & Biotechnology. 33: 159-72. PMID 16217633 DOI: 10.1007/S10295-005-0034-7 |
0.799 |
|
| 2006 |
Seth G, Ozturk M, Hu WS. Reverting cholesterol auxotrophy of NS0 cells by altering epigenetic gene silencing. Biotechnology and Bioengineering. 93: 820-7. PMID 16189819 DOI: 10.1002/Bit.20720 |
0.601 |
|
| 2006 |
Seth G, McIvor RS, Hu WS. 17Beta-hydroxysteroid dehydrogenase type 7 (Hsd17b7) reverts cholesterol auxotrophy in NS0 cells. Journal of Biotechnology. 121: 241-52. PMID 16126295 DOI: 10.1016/J.Jbiotec.2005.07.017 |
0.591 |
|
| 2006 |
Harding FJ, Cameron CM, Hu W, Kaufman DS. Scaleable Production of Hematopoietic Cells Suitable for Transfusion from Human Embryonic Stem Cells in a Stirred Bioreactor System. Blood. 108: 728-728. DOI: 10.1182/Blood.V108.11.728.728 |
0.606 |
|
| 2005 |
Wlaschin KF, Nissom PM, Gatti Mde L, Ong PF, Arleen S, Tan KS, Rink A, Cham B, Wong K, Yap M, Hu WS. EST sequencing for gene discovery in Chinese hamster ovary cells. Biotechnology and Bioengineering. 91: 592-606. PMID 16003777 DOI: 10.1002/Bit.20511 |
0.82 |
|
| 2005 |
Mehra S, Hu WS. A kinetic model of quantitative real-time polymerase chain reaction. Biotechnology and Bioengineering. 91: 848-60. PMID 15986490 DOI: 10.1002/Bit.20555 |
0.478 |
|
| 2005 |
Gadgil M, Kapur V, Hu WS. Transcriptional response of Escherichia coli to temperature shift. Biotechnology Progress. 21: 689-99. PMID 15932244 DOI: 10.1021/Bp049630L |
0.575 |
|
| 2005 |
Gadgil M, Lian W, Gadgil C, Kapur V, Hu WS. An analysis of the use of genomic DNA as a universal reference in two channel DNA microarrays. Bmc Genomics. 6: 66. PMID 15877823 DOI: 10.1186/1471-2164-6-66 |
0.758 |
|
| 2005 |
Abu-Absi SF, Hu WS, Hansen LK. Dexamethasone effects on rat hepatocyte spheroid formation and function. Tissue Engineering. 11: 415-26. PMID 15869420 DOI: 10.1089/Ten.2005.11.415 |
0.8 |
|
| 2005 |
Abu-Absi SF, Seth G, Narayanan RA, Groehler K, Lai P, Anderson ML, Sielaff T, Hu WS. Characterization of a hollow fiber bioartificial liver device. Artificial Organs. 29: 419-22. PMID 15854219 DOI: 10.1111/J.1525-1594.2005.29070.X |
0.767 |
|
| 2005 |
Seth G, Philp RJ, Denoya CD, McGrath K, Stutzman-Engwall KJ, Yap M, Hu WS. Large-scale gene expression analysis of cholesterol dependence in NS0 cells. Biotechnology and Bioengineering. 90: 552-67. PMID 15830340 DOI: 10.1002/Bit.20429 |
0.631 |
|
| 2005 |
Adams DN, Kao EY, Hypolite CL, Distefano MD, Hu WS, Letourneau PC. Growth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptide. Journal of Neurobiology. 62: 134-47. PMID 15452851 DOI: 10.1002/Neu.20075 |
0.751 |
|
| 2004 |
Abu-Absi SF, Hansen LK, Hu WS. Three-dimensional co-culture of hepatocytes and stellate cells. Cytotechnology. 45: 125-40. PMID 19003250 DOI: 10.1007/S10616-004-7996-6 |
0.799 |
|
| 2004 |
Mehra S, Hu WS, Karypis G. A Boolean algorithm for reconstructing the structure of regulatory networks. Metabolic Engineering. 6: 326-39. PMID 15491862 DOI: 10.1016/J.Ymben.2004.05.002 |
0.524 |
|
| 2004 |
Gadgil C, Yeckel A, Derby JJ, Hu WS. A diffusion-reaction model for DNA microarray assays. Journal of Biotechnology. 114: 31-45. PMID 15464596 DOI: 10.1016/J.Jbiotec.2004.05.008 |
0.684 |
|
| 2004 |
Gerdtzen ZP, Daoutidis P, Hu WS. Non-linear reduction for kinetic models of metabolic reaction networks. Metabolic Engineering. 6: 140-54. PMID 15113567 DOI: 10.1016/J.Ymben.2003.11.003 |
0.495 |
|
| 2004 |
Korke R, Gatti Mde L, Lau AL, Lim JW, Seow TK, Chung MC, Hu WS. Large scale gene expression profiling of metabolic shift of mammalian cells in culture. Journal of Biotechnology. 107: 1-17. PMID 14687967 DOI: 10.1016/J.Jbiotec.2003.09.007 |
0.821 |
|
| 2003 |
Gambhir A, Korke R, Lee J, Fu PC, Europa A, Hu WS. Analysis of cellular metabolism of hybridoma cells at distinct physiological states. Journal of Bioscience and Bioengineering. 95: 317-27. PMID 16233414 DOI: 10.1016/S1389-1723(03)80062-2 |
0.788 |
|
| 2002 |
Gadgil C, Rink A, Beattie C, Hu WS. A mathematical model for suppression subtractive hybridization. Comparative and Functional Genomics. 3: 405-22. PMID 18629052 DOI: 10.1002/Cfg.206 |
0.706 |
|
| 2002 |
Narayanan RA, Rink A, Beattie CW, Hu WS. Differential gene expression analysis during porcine hepatocyte spheroid formation. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 13: 515-23. PMID 12370782 DOI: 10.1007/S00335-002-2179-2 |
0.73 |
|
| 2002 |
Abu-Absi SF, Friend JR, Hansen LK, Hu WS. Structural polarity and functional bile canaliculi in rat hepatocyte spheroids. Experimental Cell Research. 274: 56-67. PMID 11855857 DOI: 10.1006/Excr.2001.5467 |
0.764 |
|
| 2002 |
Korke R, Rink A, Seow TK, Chung MC, Beattie CW, Hu WS. Genomic and proteomic perspectives in cell culture engineering. Journal of Biotechnology. 94: 73-92. PMID 11792453 DOI: 10.1016/S0168-1656(01)00420-5 |
0.829 |
|
| 2001 |
Tzanakakis ES, Hsiao CC, Matsushita T, Remmel RP, Hu WS. Probing enhanced cytochrome P450 2B1/2 activity in rat hepatocyte spheroids through confocal laser scanning microscopy. Cell Transplantation. 10: 329-42. PMID 11437078 DOI: 10.3727/000000001783986783 |
0.312 |
|
| 2001 |
Anderson D, Abu-Absi S, Lai P, Groehler K, Ruiz LP, Sielaff TD, Hu W. BIOARTIFICIAL LIVER DEVICES Asaio Journal. 47: 175. DOI: 10.1097/00002480-200103000-00295 |
0.749 |
|
| 2000 |
Guardia MJ, Gambhir A, Europa AF, Ramkrishna D, Hu WS. Cybernetic modeling and regulation of metabolic pathways in multiple steady states of hybridoma cells. Biotechnology Progress. 16: 847-53. PMID 11027180 DOI: 10.1021/Bp000069A |
0.369 |
|
| 2000 |
Khetan A, Hu WS, Sherman DH. Heterogeneous distribution of lysine 6-aminotransferase during cephamycin C biosynthesis in Streptomyces clavuligerus demonstrated using green fluorescent protein as a reporter. Microbiology (Reading, England). 146: 1869-80. PMID 10931891 DOI: 10.1099/00221287-146-8-1869 |
0.307 |
|
| 2000 |
Europa AF, Gambhir A, Fu PC, Hu WS. Multiple steady states with distinct cellular metabolism in continuous culture of mammalian cells. Biotechnology and Bioengineering. 67: 25-34. PMID 10581433 DOI: 10.1002/(Sici)1097-0290(20000105)67:1<25::Aid-Bit4>3.0.Co;2-K |
0.399 |
|
| 1999 |
Hansen LK, Friend JR, Remmel R, Cerra FB, Hu WS. Development of a bioartificial liver device. Methods in Molecular Medicine. 18: 423-31. PMID 21370193 DOI: 10.1385/0-89603-516-6:423 |
0.558 |
|
| 1999 |
Friend JR, Wu FJ, Hansen LK, Remmel RP, Hu WS. Formation and characterization of hepatocyte spheroids. Methods in Molecular Medicine. 18: 245-52. PMID 21370181 DOI: 10.1385/0-89603-516-6:245 |
0.625 |
|
| 1999 |
Gambhir A, Zhang C, Europa A, Hu WS. Analysis of the use of fortified medium in continuous culture of mammalian cells. Cytotechnology. 31: 243-54. PMID 19003148 DOI: 10.1023/A:1008026613975 |
0.8 |
|
| 1999 |
Wu FJ, Friend JR, Remmel RP, Cerra FB, Hu WS. Enhanced cytochrome P450 IA1 activity of self-assembled rat hepatocyte spheroids. Cell Transplantation. 8: 233-46. PMID 10442736 DOI: 10.1177/096368979900800304 |
0.56 |
|
| 1998 |
Zeng AP, Deckwer WD, Hu W. Determinants and rate laws of growth and death of hybridoma cells in continuous culture. Biotechnology and Bioengineering. 57: 642-654. PMID 10099244 DOI: 10.1002/(Sici)1097-0290(19980320)57:6<642::Aid-Bit2>3.0.Co;2-L |
0.407 |
|
| 1998 |
Zeng AP, Hu W, Deckwer WD. Variation of Stoichiometric Ratios and Their Correlation for Monitoring and Control of Animal Cell Cultures Biotechnology Progress. 14: 434-441. PMID 9622524 DOI: 10.1021/Bp9800337 |
0.354 |
|
| 1997 |
Hu WS, Friend JR, Wu FJ, Sielaff T, Peshwa MV, Lazar A, Nyberg SL, Remmel RP, Cerra FB. Development of a bioartificial liver employing xenogeneic hepatocytes. Cytotechnology. 23: 29-38. PMID 22358518 DOI: 10.1023/A:1007906512616 |
0.588 |
|
| 1997 |
Herbert CB, McLernon TL, Hypolite CL, Adams DN, Pikus L, Huang CC, Fields GB, Letourneau PC, Distefano MD, Hu WS. Micropatterning gradients and controlling surface densities of photoactivatable biomolecules on self-assembled monolayers of oligo(ethylene glycol) alkanethiolates. Chemistry & Biology. 4: 731-7. PMID 9375251 DOI: 10.1016/S1074-5521(97)90311-2 |
0.774 |
|
| 1997 |
Hypolite CL, McLernon TL, Adams DN, Chapman KE, Herbert CB, Huang CC, Distefano MD, Hu WS. Formation of microscale gradients of protein using heterobifunctional photolinkers. Bioconjugate Chemistry. 8: 658-63. PMID 9327128 DOI: 10.1021/Bc9701252 |
0.762 |
|
| 1996 |
Wu FJ, Friend JR, Lazar A, Mann HJ, Remmel RP, Cerra FB, Hu WS. Hollow fiber bioartificial liver utilizing collagen-entrapped porcine hepatocyte spheroids. Biotechnology and Bioengineering. 52: 34-44. PMID 18629850 DOI: 10.1002/(Sici)1097-0290(19961005)52:1<34::Aid-Bit4>3.0.Co;2-# |
0.589 |
|
| 1996 |
Wu FJ, Friend JR, Hsiao CC, Zilliox MJ, Ko WJ, Cerra FB, Hu WS. Efficient assembly of rat hepatocyte spheroids for tissue engineering applications. Biotechnology and Bioengineering. 50: 404-15. PMID 18626989 DOI: 10.1002/(Sici)1097-0290(19960520)50:4<404::Aid-Bit7>3.0.Co;2-P |
0.647 |
|
| 1996 |
Bancel S, Hu W. Confocal Laser Scanning Microscopy Examination of Cell Distribution in Macroporous Microcarriers Biotechnology Progress. 12: 398-402. PMID 8652124 DOI: 10.1021/Bp960023A |
0.378 |
|
| 1995 |
Lazar A, Peshwa MV, Wu FJ, Chi CM, Cerra FB, Hu WS. Formation of porcine hepatocyte spheroids for use in a bioartificial liver. Cell Transplantation. 4: 259-68. PMID 7640865 DOI: 10.1016/0963-6897(94)00058-R |
0.331 |
|
| 1995 |
Gonzalez JF, Hu W. Pentachlorophenol biodegradation: Simple models Environmental Technology. 16: 287-293. DOI: 10.1080/09593331608616271 |
0.335 |
|
| 1994 |
Zhou W, Hu W. On‐line characterization of a hybridoma cell culture process Biotechnology and Bioengineering. 44: 170-177. PMID 18618682 DOI: 10.1002/Bit.260440205 |
0.375 |
|
| 1993 |
Malmberg LH, Hu WS, Sherman DH. Precursor flux control through targeted chromosomal insertion of the lysine epsilon-aminotransferase (lat) gene in cephamycin C biosynthesis. Journal of Bacteriology. 175: 6916-24. PMID 8226634 DOI: 10.1128/Jb.175.21.6916-6924.1993 |
0.359 |
|
| 1993 |
Malmberg LH, Hu WS. Identification of rate-limiting steps in cephalosporin C biosynthesis in Cephalosporium acremonium: a theoretical analysis. Applied Microbiology and Biotechnology. 38: 122-8. PMID 1369008 DOI: 10.1007/Bf00169431 |
0.315 |
|
| 1992 |
Shatford RA, Nyberg SL, Meier SJ, White JG, Payne WD, Hu W, Cerra FB. Hepatocyte function in a hollow fiber bioreactor: a potential bioartificial liver. Journal of Surgical Research. 53: 549-557. PMID 1494286 DOI: 10.1016/0022-4804(92)90253-V |
0.323 |
|
| 1991 |
Frame KK, Hu W. Kinetic study of hybridoma cell growth in continuous culture. I. A model for non-producing cells. Biotechnology and Bioengineering. 37: 55-64. PMID 18597307 DOI: 10.1002/Bit.260370109 |
0.328 |
|
| 1991 |
Philippidis GP, Malmberg LH, Hu WS, Schottel JL. Effect of gene amplification on mercuric ion reduction activity of Escherichia coli Applied and Environmental Microbiology. 57: 3558-3564. PMID 1785930 DOI: 10.1128/Aem.57.12.3558-3564.1991 |
0.389 |
|
| 1991 |
Goetghebeur S, Hu WS. Cultivation of anchorage-dependent animal cells in microsphere-induced aggregate culture. Applied Microbiology and Biotechnology. 34: 735-41. PMID 1367199 DOI: 10.1007/Bf00169343 |
0.376 |
|
| 1991 |
Nikolai TJ, Peshwa MV, Goetghebeur S, Hu WS. Improved microscopic observation of mammalian cells on microcarriers by fluorescent staining. Cytotechnology. 5: 141-6. PMID 1367155 DOI: 10.1007/Bf00365430 |
0.323 |
|
| 1991 |
Goetghebeur S, Hu W. Microsphere-Induced Aggregate Culture Of Animal Cells Production of Biologicals From Animal Cells in Culture. 3: 423-428. DOI: 10.1016/B978-0-7506-1103-9.50079-2 |
0.373 |
|
| 1987 |
Dodge TC, Ji GY, Hu W. Loss of viability in hybridoma cell culture ― a kinetic study Enzyme and Microbial Technology. 9: 607-611. DOI: 10.1016/0141-0229(87)90114-1 |
0.358 |
|
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