Ivan Rusyn - Publications

Affiliations: 
Environmental Sciences and Engineering University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Toxicology

197 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Burnett SD, Blanchette AD, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA, Rusyn I. Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicology and Applied Pharmacology. 114711. PMID 31425687 DOI: 10.1016/j.taap.2019.114711  0.52
2019 Luo YS, Cichocki JA, Hsieh NH, Lewis L, Wright FA, Threadgill DW, Chiu WA, Rusyn I. Using Collaborative Cross Mouse Population to Fill Data Gaps in Risk Assessment: A Case Study of Population-Based Analysis of Toxicokinetics and Kidney Toxicodynamics of Tetrachloroethylene. Environmental Health Perspectives. 127: 67011. PMID 31246107 DOI: 10.1289/EHP5105  0.52
2019 Borowa-Mazgaj B, de Conti A, Tryndyak V, Steward CR, Jimenez L, Melnyk S, Seneshaw M, Mirshahi F, Rusyn I, Beland FA, Sanyal AJ, Pogribny IP. Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31086990 DOI: 10.1093/toxsci/kfz110  0.36
2019 Lewis L, Borowa-Mazgaj B, de Conti A, Chappell GA, Luo YS, Bodnar W, Konganti K, Wright FA, Threadgill DW, Chiu WA, Pogribny IP, Rusyn I. Population-based analysis of DNA damage and epigenetic effects of 1,3-butadiene in the mouse. Chemical Research in Toxicology. PMID 30990016 DOI: 10.1021/acs.chemrestox.9b00035  0.52
2019 Perry A, Lynch RM, Rusyn I, Threadgill DW. Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes. G3 (Bethesda, Md.). PMID 30898898 DOI: 10.1534/g3.119.400161  0.48
2019 Alves VM, Borba J, Capuzzi SJ, Muratov E, Andrade CH, Rusyn I, Tropsha A. Oy Vey! A Comment on "Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships Outperforming Animal Test Reproducibility". Toxicological Sciences : An Official Journal of the Society of Toxicology. 167: 3-4. PMID 30500930 DOI: 10.1093/toxsci/kfy286  0.56
2018 Lewis L, Chappell GA, Kobets T, O'Brian BE, Sangaraju D, Kosyk O, Bodnar W, Tretyakova NY, Pogribny IP, Rusyn I. Sex-specific differences in genotoxic and epigenetic effects of 1,3-butadiene among mouse tissues. Archives of Toxicology. PMID 30552462 DOI: 10.1007/s00204-018-2374-x  0.52
2018 Onel M, Beykal B, Wang M, Grimm FA, Zhou L, Wright FA, Phillips TD, Rusyn I, Pistikopoulos EN. Optimal Chemical Grouping and Sorbent Material Design by Data Analysis, Modeling and Dimensionality Reduction Techniques. Escape. European Symposium On Computer Aided Process Engineering. 43: 421-426. PMID 30534632 DOI: 10.1016/B978-0-444-64235-6.50076-0  0.52
2018 Furuya S, Cichocki JA, Konganti K, Dreval K, Uehara T, Katou Y, Fukushima H, Kono H, Pogribny IP, Argemi J, Bataller R, Rusyn I. Histopathological and molecular signatures of a mouse model of acute-on-chronic alcoholic liver injury demonstrate concordance with human alcoholic hepatitis. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30517762 DOI: 10.1093/toxsci/kfy292  0.36
2018 Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I. Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers. Regulatory Toxicology and Pharmacology : Rtp. PMID 30471335 DOI: 10.1016/j.yrtph.2018.11.011  0.52
2018 Low Y, Alves VM, Fourches D, Sedykh A, Andrade CH, Muratov EN, Rusyn I, Tropsha A. Chemistry-Wide Association Studies (CWAS): A Novel Framework for Identifying and Interpreting Structure-Activity Relationships. Journal of Chemical Information and Modeling. PMID 30376324 DOI: 10.1021/acs.jcim.8b00450  0.56
2018 Cichocki JA, Luo YS, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. Modulation of tetrachloroethylene-associated kidney effects by nonalcoholic fatty liver or steatohepatitis in male C57BL/6J mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30202895 DOI: 10.1093/toxsci/kfy223  0.48
2018 Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh NH, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I. A human population-based organotypic in vitro model for cardiotoxicity screening. Altex. PMID 29999168 DOI: 10.14573/altex.1805301  0.52
2018 Luo YS, Furuya S, Soldatov VY, Kosyk O, Yoo HS, Fukushima H, Lewis L, Iwata Y, Rusyn I. Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29897530 DOI: 10.1093/toxsci/kfy099  0.32
2018 Konganti K, Ehrlich A, Rusyn I, Threadgill DW. gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population. G3 (Bethesda, Md.). PMID 29880557 DOI: 10.1534/g3.118.200230  0.48
2018 Wignall JA, Muratov E, Sedykh A, Guyton KZ, Tropsha A, Rusyn I, Chiu WA. Conditional Toxicity Value (CTV) Predictor: An Approach for Generating Quantitative Risk Estimates for Chemicals. Environmental Health Perspectives. 126: 057008. PMID 29847084 DOI: 10.1289/EHP2998  0.56
2018 Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models. Bmc Bioinformatics. 19: 80. PMID 29506467 DOI: 10.1186/s12859-018-2089-2  0.52
2018 Rusyn I, Kleeberger SR, McAllister KA, French JE, Svenson KL. Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 29460122 DOI: 10.1007/s00335-018-9740-0  0.48
2018 Israel JW, Chappell GA, Simon JM, Pott S, Safi A, Lewis L, Cotney P, Boulos HS, Bodnar W, Lieb JD, Crawford GE, Furey TS, Rusyn I. Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 29429127 DOI: 10.1007/s00335-018-9739-6  0.52
2018 Venkatratnam A, House JS, Konganti K, McKenney C, Threadgill DW, Chiu WA, Aylor DL, Wright FA, Rusyn I. Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 29353386 DOI: 10.1007/s00335-018-9734-y  0.52
2018 Seniutkin O, Furuya S, Luo YS, Cichocki JA, Fukushima H, Kato Y, Sugimoto H, Matsumoto T, Uehara T, Rusyn I. Effects of pirfenidone in acute and sub-chronic liver fibrosis, and an initiation-promotion cancer model in the mouse. Toxicology and Applied Pharmacology. 339: 1-9. PMID 29197520 DOI: 10.1016/j.taap.2017.11.024  0.32
2017 Rusyn I, Pogribny IP. Editorial overview of the special issue on genomic toxicology epigenetics. Current Opinion in Toxicology. 6: i-iii. PMID 29607421 DOI: 10.1016/j.cotox.2017.11.006  0.36
2017 de Conti A, Ortega JF, Tryndyak V, Dreval K, Moreno FS, Rusyn I, Beland FA, Pogribny IP. MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis. Oncotarget. 8: 88517-88528. PMID 29179453 DOI: 10.18632/oncotarget.19774  0.36
2017 House JS, Grimm FA, Jima DD, Zhou YH, Rusyn I, Wright FA. A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics. Frontiers in Genetics. 8: 168. PMID 29163636 DOI: 10.3389/fgene.2017.00168  0.52
2017 Pogribny IP, Dreval K, Kindrat I, Melnyk S, Jimenez L, de Conti A, Tryndyak V, Pogribna M, Ortega JF, James SJ, Rusyn I, Beland FA. Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29127188 DOI: 10.1096/fj.201700866R  0.36
2017 Chappell GA, Israel JW, Simon JM, Pott S, Safi A, Eklund K, Sexton KG, Bodnar W, Lieb JD, Crawford GE, Rusyn I, Furey TS. Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice. Environmental Health Perspectives. 125: 107006. PMID 29038090 DOI: 10.1289/EHP1937  0.52
2017 Li G, Shabalin AA, Rusyn I, Wright FA, Nobel AB. An empirical Bayes approach for multiple tissue eQTL analysis. Biostatistics (Oxford, England). PMID 29029013 DOI: 10.1093/biostatistics/kxx048  0.52
2017 Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 159: 481. PMID 28962530 DOI: 10.1093/toxsci/kfx158  0.48
2017 Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 159: 102-113. PMID 28903486 DOI: 10.1093/toxsci/kfx120  0.48
2017 Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chiu WA, Threadgill DW, Rusyn I. Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population. Environmental Health Perspectives. 125: 057006. PMID 28572074 DOI: 10.1289/EHP788  0.48
2017 Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar W, Konganti K, Threadgill DW, Gillespie KM, Aylor DL, Wright FA, Chiu WA, Rusyn I. Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28369613 DOI: 10.1093/toxsci/kfx065  0.52
2017 Dreval K, de Conti A, Furuya S, Beland FA, Rusyn I, Pogribny IP. miR-1247 blocks SOX9-mediated regeneration in alcohol- and fibrosis-associated acute kidney injury in mice. Toxicology. PMID 28285099 DOI: 10.1016/j.tox.2017.03.004  0.36
2017 Cichocki JA, Furuya S, Konganti K, Luo YS, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene. The Journal of Pharmacology and Experimental Therapeutics. PMID 28148637 DOI: 10.1124/jpet.116.238790  0.48
2016 Grimm FA, Iwata Y, Sirenko O, Chappell GA, Wright FA, Reif DM, Braisted J, Gerhold DL, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde AM, ... Rusyn I, et al. A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. Green Chemistry : An International Journal and Green Chemistry Resource : Gc. 18: 4407-4419. PMID 28035192 DOI: 10.1039/c6gc01147k  0.52
2016 Chiu WA, Wright FA, Rusyn I. A tiered, Bayesian approach to estimating of population variability for regulatory decision-making. Altex. PMID 27960008 DOI: 10.14573/altex.1608251  0.52
2016 Furuya S, Chappell GA, Iwata Y, Uehara T, Kato Y, Kono H, Bataller R, Rusyn I. A mouse model of alcoholic liver fibrosis-associated acute kidney injury identifies key molecular pathways. Toxicology and Applied Pharmacology. PMID 27641628 DOI: 10.1016/j.taap.2016.09.011  0.52
2016 Chappell G, Pogribny IP, Guyton KZ, Rusyn I. Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review. Mutation Research. Reviews in Mutation Research. 768: 27-45. PMID 27234561 DOI: 10.1016/j.mrrev.2016.03.004  0.56
2016 Chappell G, Silva GO, Uehara T, Pogribny IP, Rusyn I. Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease. Cancer Medicine. PMID 26778414 DOI: 10.1002/cam4.606  0.36
2015 Pogribny IP, Beland FA, Rusyn I. The role of microRNAs in the development and progression of chemical-associated cancers. Toxicology and Applied Pharmacology. PMID 26621330 DOI: 10.1016/j.taap.2015.11.013  0.36
2015 Grimm FA, Iwata Y, Sirenko O, Bittner M, Rusyn I. High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes. Assay and Drug Development Technologies. PMID 26539751 DOI: 10.1089/adt.2015.659  0.56
2015 Low YS, Caster O, Bergvall T, Fourches D, Zang X, Norén GN, Rusyn I, Edwards R, Tropsha A. Cheminformatics-aided pharmacovigilance: application to Stevens-Johnson Syndrome. Journal of the American Medical Informatics Association : Jamia. PMID 26499102 DOI: 10.1093/jamia/ocv127  0.56
2015 Eduati F, Mangravite LM, Wang T, Tang H, Bare JC, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, ... ... Rusyn I, et al. Erratum: Prediction of human population responses to toxic compounds by a collaborative competition. Nature Biotechnology. 33: 1109. PMID 26448092 DOI: 10.1038/nbt1015-1109a  0.52
2015 Abdo N, Wetmore BA, Chappell GA, Shea D, Wright FA, Rusyn I. In vitro screening for population variability in toxicity of pesticide-containing mixtures. Environment International. 85: 147-55. PMID 26386728 DOI: 10.1016/j.envint.2015.09.012  0.56
2015 Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar W, Sweet S, Knap A, Wade T, Campbell J, Clewell HJ, Melnyk SB, Chiu WA, Rusyn I. The contribution of peroxisome proliferator-activated receptor alpha to the relationship between toxicokinetics and toxicodynamics of trichloroethylene. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26136231 DOI: 10.1093/toxsci/kfv134  0.56
2015 Marrone AK, Shpyleva S, Chappell G, Tryndyak V, Uehara T, Tsuchiya M, Beland FA, Rusyn I, Pogribny IP. Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice. Molecular Carcinogenesis. PMID 25865624 DOI: 10.1002/mc.22323  0.56
2015 Pearce N, Blair A, Vineis P, Ahrens W, Andersen A, Anto JM, Armstrong BK, Baccarelli AA, Beland FA, Berrington A, Bertazzi PA, Birnbaum LS, Brownson RC, Bucher JR, Cantor KP, ... ... Rusyn I, et al. IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans. Environmental Health Perspectives. 123: 507-14. PMID 25712798 DOI: 10.1289/ehp.1409149  0.56
2015 Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, ... Rusyn I, et al. Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environmental Health Perspectives. 123: 458-66. PMID 25622337 DOI: 10.1289/ehp.1408775  0.52
2015 Linkov I, Massey O, Keisler J, Rusyn I, Hartung T. From "weight of evidence" to quantitative data integration using multicriteria decision analysis and Bayesian methods. Altex. 32: 3-8. PMID 25592482 DOI: 10.14573/altex.1412231  0.56
2015 Yoo HS, Bradford BU, Kosyk O, Uehara T, Shymonyak S, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. Journal of Toxicology and Environmental Health. Part A. 78: 32-49. PMID 25424545 DOI: 10.1080/15287394.2015.958418  0.56
2015 Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects. Journal of Toxicology and Environmental Health. Part A. 78: 15-31. PMID 25424544 DOI: 10.1080/15287394.2015.958417  0.56
2015 Guyton KZ, Loomis D, Grosse Y, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Scoccianti C, Mattock H, Straif K, Blair A, Fritschi L, McLaughlin J, Sergi CM, Calaf GM, Le Curieux F, ... ... Rusyn I, et al. Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate The Lancet Oncology. 16: 490-491. DOI: 10.1016/S1470-2045(15)70134-8  0.56
2014 Sirenko O, Hesley J, Rusyn I, Cromwell EF. High-content high-throughput assays for characterizing the viability and morphology of human iPSC-derived neuronal cultures. Assay and Drug Development Technologies. 12: 536-47. PMID 25506803 DOI: 10.1089/adt.2014.592  0.56
2014 Lash LH, Chiu WA, Guyton KZ, Rusyn I. Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity. Mutation Research. Reviews in Mutation Research. 762: 22-36. PMID 25484616 DOI: 10.1016/j.mrrev.2014.04.003  0.56
2014 Chappell G, Kobets T, O'Brien B, Tretyakova N, Sangaraju D, Kosyk O, Sexton KG, Bodnar W, Pogribny IP, Rusyn I. Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 142: 375-84. PMID 25237060 DOI: 10.1093/toxsci/kfu191  0.56
2014 Benbrahim-Tallaa L, Lauby-Secretan B, Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Guha N, Mattock H, Straif K, Rusyn II, Bartell SM, Cesta MF, Chiu W, Cooper G, et al. Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone The Lancet Oncology. 15: 924-925. PMID 25225686 DOI: 10.1016/S1470-2045(14)70316-X  0.56
2014 Uehara T, Pogribny IP, Rusyn I. The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. 66: 14.30.1-14.30.10. PMID 25181010 DOI: 10.1002/0471141755.ph1430s66  0.36
2014 Politi R, Rusyn I, Tropsha A. Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods. Toxicology and Applied Pharmacology. 280: 177-89. PMID 25058446 DOI: 10.1016/j.taap.2014.07.009  0.56
2014 Low YS, Sedykh AY, Rusyn I, Tropsha A. Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays. Current Topics in Medicinal Chemistry. 14: 1356-64. PMID 24805064 DOI: 10.2174/1568026614666140506121116  0.56
2014 Wignall JA, Shapiro AJ, Wright FA, Woodruff TJ, Chiu WA, Guyton KZ, Rusyn I. Standardizing benchmark dose calculations to improve science-based decisions in human health assessments. Environmental Health Perspectives. 122: 499-505. PMID 24569956 DOI: 10.1289/ehp.1307539  0.56
2014 Chiu WA, Campbell JL, Clewell HJ, Zhou YH, Wright FA, Guyton KZ, Rusyn I. Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse. Environmental Health Perspectives. 122: 456-63. PMID 24518055 DOI: 10.1289/ehp.1307623  0.56
2014 Chappell G, Kutanzi K, Uehara T, Tryndyak V, Hong HH, Hoenerhoff M, Beland FA, Rusyn I, Pogribny IP. Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. International Journal of Cancer. Journal International Du Cancer. 134: 2778-88. PMID 24242335 DOI: 10.1002/ijc.28610  0.56
2014 Sirenko O, Hesley J, Rusyn I, Cromwell EF. High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells. Assay and Drug Development Technologies. 12: 43-54. PMID 24229356 DOI: 10.1089/adt.2013.520  0.56
2014 Buck LD, Inman SW, Rusyn I, Griffith LG. Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix. Biotechnology and Bioengineering. 111: 1018-27. PMID 24222008 DOI: 10.1002/bit.25152  0.56
2014 Rusyn I, Chiu WA, Lash LH, Kromhout H, Hansen J, Guyton KZ. Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard. Pharmacology & Therapeutics. 141: 55-68. PMID 23973663 DOI: 10.1016/j.pharmthera.2013.08.004  0.56
2014 Rusyn I, Lemon SM. Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies? Cancer Letters. 345: 210-5. PMID 23871966 DOI: 10.1016/j.canlet.2013.06.028  0.56
2014 Pogribny IP, Rusyn I. Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma. Cancer Letters. 342: 223-30. PMID 22306342 DOI: 10.1016/j.canlet.2012.01.038  0.56
2013 Sirenko O, Cromwell EF, Crittenden C, Wignall JA, Wright FA, Rusyn I. Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity. Toxicology and Applied Pharmacology. 273: 500-7. PMID 24095675 DOI: 10.1016/j.taap.2013.09.017  0.56
2013 Kushman ME, Kraft AD, Guyton KZ, Chiu WA, Makris SL, Rusyn I. A systematic approach for identifying and presenting mechanistic evidence in human health assessments. Regulatory Toxicology and Pharmacology : Rtp. 67: 266-77. PMID 23959061 DOI: 10.1016/j.yrtph.2013.08.005  0.56
2013 Low Y, Sedykh A, Fourches D, Golbraikh A, Whelan M, Rusyn I, Tropsha A. Integrative chemical-biological read-across approach for chemical hazard classification. Chemical Research in Toxicology. 26: 1199-208. PMID 23848138 DOI: 10.1021/tx400110f  0.56
2013 Zhang L, Sedykh A, Tripathi A, Zhu H, Afantitis A, Mouchlis VD, Melagraki G, Rusyn I, Tropsha A. Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches. Toxicology and Applied Pharmacology. 272: 67-76. PMID 23707773 DOI: 10.1016/j.taap.2013.04.032  0.56
2013 Hakenewerth AM, Millikan RC, Rusyn I, Herring AH, Weissler MC, Funkhouser WK, North KE, Barnholtz-Sloan JS, Olshan AF. Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer. Cancer Epidemiology. 37: 479-91. PMID 23632049 DOI: 10.1016/j.canep.2013.03.010  0.56
2013 Rusyn I, Bataller R. Reply to: "The autophagic response to alcohol toxicity: the missing layer". Journal of Hepatology. 59: 399-400. PMID 23624250 DOI: 10.1016/j.jhep.2013.04.015  0.56
2013 Soldatow VY, Lecluyse EL, Griffith LG, Rusyn I. In vitro models for liver toxicity testing. Toxicology Research. 2: 23-39. PMID 23495363 DOI: 10.1039/C2TX20051A  0.56
2013 Pogribny IP, Kutanzi K, Melnyk S, de Conti A, Tryndyak V, Montgomery B, Pogribna M, Muskhelishvili L, Latendresse JR, James SJ, Beland FA, Rusyn I. Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2233-43. PMID 23439872 DOI: 10.1096/fj.12-227116  0.56
2013 Rusyn I, Bataller R. Alcohol and toxicity. Journal of Hepatology. 59: 387-8. PMID 23391479 DOI: 10.1016/j.jhep.2013.01.035  0.56
2013 Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymonyak S, Bradford BU, Boorman GA, Bataller R, Rusyn I. Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 132: 53-63. PMID 23288052 DOI: 10.1093/toxsci/kfs342  0.56
2013 Reif DM, Sypa M, Lock EF, Wright FA, Wilson A, Cathey T, Judson RR, Rusyn I. ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence. Bioinformatics (Oxford, England). 29: 402-3. PMID 23202747 DOI: 10.1093/bioinformatics/bts686  0.56
2013 Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I. Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicology and Applied Pharmacology. 266: 224-32. PMID 23200774 DOI: 10.1016/j.taap.2012.11.019  0.56
2013 Zeise L, Bois FY, Chiu WA, Hattis D, Rusyn I, Guyton KZ. Addressing human variability in next-generation human health risk assessments of environmental chemicals. Environmental Health Perspectives. 121: 23-31. PMID 23086705 DOI: 10.1289/ehp.1205687  0.56
2013 Sirenko O, Crittenden C, Callamaras N, Hesley J, Chen YW, Funes C, Rusyn I, Anson B, Cromwell EF. Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells. Journal of Biomolecular Screening. 18: 39-53. PMID 22972846 DOI: 10.1177/1087057112457590  0.56
2013 Pogribny IP, Rusyn I. Environmental toxicants, epigenetics, and cancer. Advances in Experimental Medicine and Biology. 754: 215-32. PMID 22956504 DOI: 10.1007/978-1-4419-9967-2_11  0.56
2013 Zeise L, Bois FY, Chiu WA, Hattis D, Rusyn I, Guyton KZ. Towards a better consideration of the interindividual variability in chemical risk assessment Environnement, Risques Et Sante. 12: 211-212.  0.56
2012 Tryndyak V, de Conti A, Kobets T, Kutanzi K, Koturbash I, Han T, Fuscoe JC, Latendresse JR, Melnyk S, Shymonyak S, Collins L, Ross SA, Rusyn I, Beland FA, Pogribny IP. Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4592-602. PMID 22872676 DOI: 10.1096/fj.12-209569  0.56
2012 Tryndyak VP, Latendresse JR, Montgomery B, Ross SA, Beland FA, Rusyn I, Pogribny IP. Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet. Toxicology and Applied Pharmacology. 262: 52-9. PMID 22561871 DOI: 10.1016/j.taap.2012.04.018  0.56
2012 Rusyn I, Sedykh A, Low Y, Guyton KZ, Tropsha A. Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 1-9. PMID 22387746 DOI: 10.1093/toxsci/kfs095  0.56
2012 Yeatts KB, El-Sadig M, Leith D, Kalsbeek W, Al-Maskari F, Couper D, Funk WE, Zoubeidi T, Chan RL, Trent CB, Davidson CA, Boundy MG, Kassab MM, Hasan MY, Rusyn I, et al. Indoor air pollutants and health in the United Arab Emirates. Environmental Health Perspectives. 120: 687-94. PMID 22357138 DOI: 10.1289/ehp.1104090  0.56
2012 Yeatts KB, El-Sadig M, Ali HI, Al-Maskari F, Campbell A, Ng SW, Reeves L, Chan RL, Davidson CA, Funk WE, Boundy MG, Leith D, Popkin B, Gibson JM, Rusyn I, et al. Conducting environmental health research in the Arabian Middle East: lessons learned and opportunities. Environmental Health Perspectives. 120: 632-6. PMID 22356946 DOI: 10.1289/ehp.1104031  0.56
2012 Tsuchiya M, Ji C, Kosyk O, Shymonyak S, Melnyk S, Kono H, Tryndyak V, Muskhelishvili L, Pogribny IP, Kaplowitz N, Rusyn I. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology (Baltimore, Md.). 56: 130-9. PMID 22307928 DOI: 10.1002/hep.25641  0.56
2012 Wright FA, Shabalin AA, Rusyn I. Computational tools for discovery and interpretation of expression quantitative trait loci. Pharmacogenomics. 13: 343-52. PMID 22304583 DOI: 10.2217/pgs.11.185  0.56
2012 Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou YH, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 126: 578-88. PMID 22268004 DOI: 10.1093/toxsci/kfs023  0.56
2012 Rusyn I, Corton JC. Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate. Mutation Research. 750: 141-58. PMID 22198209 DOI: 10.1016/j.mrrev.2011.12.004  0.56
2012 Jeannot E, Boorman GA, Kosyk O, Bradford BU, Shymoniak S, Tumurbaatar B, Weinman SA, Melnyk SB, Tryndyak V, Pogribny IP, Rusyn I. Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice. International Journal of Cancer. Journal International Du Cancer. 130: 1347-56. PMID 21500192 DOI: 10.1002/ijc.26140  0.56
2011 Hakenewerth AM, Millikan RC, Rusyn I, Herring AH, North KE, Barnholtz-Sloan JS, Funkhouser WF, Weissler MC, Olshan AF. Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 20: 2438-49. PMID 21940907 DOI: 10.1158/1055-9965.EPI-11-0649  0.56
2011 Low Y, Uehara T, Minowa Y, Yamada H, Ohno Y, Urushidani T, Sedykh A, Muratov E, Kuz'min V, Fourches D, Zhu H, Rusyn I, Tropsha A. Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches. Chemical Research in Toxicology. 24: 1251-62. PMID 21699217 DOI: 10.1021/tx200148a  0.56
2011 Gatti DM, Lu L, Williams RW, Sun W, Wright FA, Threadgill DW, Rusyn I. MicroRNA expression in the livers of inbred mice. Mutation Research. 714: 126-33. PMID 21616085 DOI: 10.1016/j.mrfmmm.2011.05.007  0.56
2011 Koturbash I, Scherhag A, Sorrentino J, Sexton K, Bodnar W, Swenberg JA, Beland FA, Pardo-Manuel Devillena F, Rusyn I, Pogribny IP. Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene. Toxicological Sciences : An Official Journal of the Society of Toxicology. 122: 448-56. PMID 21602187 DOI: 10.1093/toxsci/kfr133  0.56
2011 Jeannot E, Pogribny IP, Beland FA, Rusyn I. Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells. Cancer Letters. 301: 161-7. PMID 21168264 DOI: 10.1016/j.canlet.2010.11.010  0.56
2011 Koturbash I, Scherhag A, Sorrentino J, Sexton K, Bodnar W, Tryndyak V, Latendresse JR, Swenberg JA, Beland FA, Pogribny IP, Rusyn I. Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene. Environmental Health Perspectives. 119: 635-40. PMID 21147608 DOI: 10.1289/ehp.1002910  0.56
2011 Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, DeSimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: 206-17. PMID 21135412 DOI: 10.1093/toxsci/kfq362  0.56
2011 Sedykh A, Zhu H, Tang H, Zhang L, Richard A, Rusyn I, Tropsha A. Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity. Environmental Health Perspectives. 119: 364-70. PMID 20980217 DOI: 10.1289/ehp.1002476  0.56
2011 O'Shea SH, Schwarz J, Kosyk O, Ross PK, Ha MJ, Wright FA, Rusyn I. In vitro screening for population variability in chemical toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 119: 398-407. PMID 20952501 DOI: 10.1093/toxsci/kfq322  0.56
2010 Starlard-Davenport A, Tryndyak V, Kosyk O, Ross SR, Rusyn I, Beland FA, Pogribny IP. Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis. Journal of Nutrigenetics and Nutrigenomics. 3: 259-66. PMID 21474957 DOI: 10.1159/000324362  0.56
2010 Gatti DM, Barry WT, Nobel AB, Rusyn I, Wright FA. Heading down the wrong pathway: on the influence of correlation within gene sets. Bmc Genomics. 11: 574. PMID 20955544 DOI: 10.1186/1471-2164-11-574  0.56
2010 Martinez SM, Bradford BU, Soldatow VY, Kosyk O, Sandot A, Witek R, Kaiser R, Stewart T, Amaral K, Freeman K, Black C, LeCluyse EL, Ferguson SS, Rusyn I. Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicity. Toxicology and Applied Pharmacology. 249: 208-16. PMID 20869979 DOI: 10.1016/j.taap.2010.09.012  0.56
2010 Cowherd RB, Cowerd RB, Asmar MM, Alderman JM, Alderman EA, Garland AL, Busby WH, Bodnar WM, Rusyn I, Medoff BD, Tisch R, Mayer-Davis E, Swenberg JA, Zeisel SH, Combs TP. Adiponectin lowers glucose production by increasing SOGA. The American Journal of Pathology. 177: 1936-45. PMID 20813965 DOI: 10.2353/ajpath.2010.100363  0.56
2010 Formeister EJ, Tsuchiya M, Fujii H, Shpyleva S, Pogribny IP, Rusyn I. Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma. Mutation Research. 692: 26-33. PMID 20736025 DOI: 10.1016/j.mrfmmm.2010.07.013  0.56
2010 Rusyn I, Gatti DM, Wiltshire T, Wilshire T, Kleeberger SR, Threadgill DW. Toxicogenetics: population-based testing of drug and chemical safety in mouse models. Pharmacogenomics. 11: 1127-36. PMID 20704464 DOI: 10.2217/pgs.10.100  0.56
2010 Gatti DM, Zhao N, Chesler EJ, Bradford BU, Shabalin AA, Yordanova R, Lu L, Rusyn I. Sex-specific gene expression in the BXD mouse liver. Physiological Genomics. 42: 456-68. PMID 20551147 DOI: 10.1152/physiolgenomics.00110.2009  0.56
2010 Pogribny IP, Starlard-Davenport A, Tryndyak VP, Han T, Ross SA, Rusyn I, Beland FA. Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Laboratory Investigation; a Journal of Technical Methods and Pathology. 90: 1437-46. PMID 20548288 DOI: 10.1038/labinvest.2010.113  0.56
2010 Rusyn I, Daston GP. Computational toxicology: realizing the promise of the toxicity testing in the 21st century. Environmental Health Perspectives. 118: 1047-50. PMID 20483702 DOI: 10.1289/ehp.1001925  0.56
2010 Starlard-Davenport A, Tryndyak V, Kosyk O, Ross SR, Rusyn I, Beland FA, Pogribny IP. Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis. World Review of Nutrition and Dietetics. 101: 123-30. PMID 20436259 DOI: 10.1159/000314517  0.56
2010 Jeannot E, Mellottee L, Bioulac-Sage P, Balabaud C, Scoazec JY, Tran Van Nhieu J, Bacq Y, Michalak S, Buob D, Laurent-Puig P, Rusyn I, Zucman-Rossi J. Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage. Diabetes. 59: 1836-44. PMID 20393147 DOI: 10.2337/db09-1819  0.56
2010 Tsuchiya M, Parker JS, Kono H, Matsuda M, Fujii H, Rusyn I. Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma. Molecular Cancer. 9: 74. PMID 20380719 DOI: 10.1186/1476-4598-9-74  0.56
2010 Rodgers AD, Zhu H, Fourches D, Rusyn I, Tropsha A. Modeling liver-related adverse effects of drugs using knearest neighbor quantitative structure-activity relationship method. Chemical Research in Toxicology. 23: 724-32. PMID 20192250 DOI: 10.1021/tx900451r  0.56
2010 Powell CL, Bradford BU, Craig CP, Tsuchiya M, Uehara T, O'Connell TM, Pogribny IP, Melnyk S, Koop DR, Bleyle L, Threadgill DW, Rusyn I. Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicological Sciences : An Official Journal of the Society of Toxicology. 115: 131-9. PMID 20118189 DOI: 10.1093/toxsci/kfq031  0.56
2010 Allen N, Anderson LM, Beland FA, Bénichou J, Beral V, Bloomfield K, Brooks PJ, Cai L, Cho SI, Crabb DW, Eriksson P, Gapstur SM, Gmel G, Griciute LL, Kono S, ... ... Rusyn I, et al. Alcohol consumption and ethyl carbamate Iarc Monographs On the Evaluation of Carcinogenic Risks to Humans. 96: 1-1379.  0.56
2009 Zhu H, Ye L, Richard A, Golbraikh A, Wright FA, Rusyn I, Tropsha A. A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents. Environmental Health Perspectives. 117: 1257-64. PMID 19672406 DOI: 10.1289/ehp.0800471  0.56
2009 Gatti DM, Harrill AH, Wright FA, Threadgill DW, Rusyn I. Replication and narrowing of gene expression quantitative trait loci using inbred mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 20: 437-46. PMID 19609828 DOI: 10.1007/s00335-009-9199-0  0.56
2009 Kim S, Collins LB, Boysen G, Swenberg JA, Gold A, Ball LM, Bradford BU, Rusyn I. Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicology. 262: 230-8. PMID 19549554 DOI: 10.1016/j.tox.2009.06.013  0.56
2009 Pogribny IP, Tryndyak VP, Bagnyukova TV, Melnyk S, Montgomery B, Ross SA, Latendresse JR, Rusyn I, Beland FA. Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. Journal of Hepatology. 51: 176-86. PMID 19450891 DOI: 10.1016/j.jhep.2009.03.021  0.56
2009 Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicological Sciences : An Official Journal of the Society of Toxicology. 110: 235-43. PMID 19420014 DOI: 10.1093/toxsci/kfp096  0.56
2009 Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, ... ... Rusyn I, et al. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Research. 19: 1507-15. PMID 19416960 DOI: 10.1101/gr.090241.108  0.56
2009 Kim S, Kim D, Pollack GM, Collins LB, Rusyn I. Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicology and Applied Pharmacology. 238: 90-9. PMID 19409406 DOI: 10.1016/j.taap.2009.04.019  0.56
2009 Ross PK, Woods CG, Bradford BU, Kosyk O, Gatti DM, Cunningham ML, Rusyn I. Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver. Toxicology and Applied Pharmacology. 235: 199-207. PMID 19136022 DOI: 10.1016/j.taap.2008.12.011  0.56
2009 Gatti DM, Sypa M, Rusyn I, Wright FA, Barry WT. SAFEGUI: resampling-based tests of categorical significance in gene expression data made easy. Bioinformatics (Oxford, England). 25: 541-2. PMID 19098030 DOI: 10.1093/bioinformatics/btn655  0.56
2009 Gatti DM, Shabalin AA, Lam TC, Wright FA, Rusyn I, Nobel AB. FastMap: fast eQTL mapping in homozygous populations. Bioinformatics (Oxford, England). 25: 482-9. PMID 19091771 DOI: 10.1093/bioinformatics/btn648  0.56
2008 Han J, Danell RM, Patel JR, Gumerov DR, Scarlett CO, Speir JP, Parker CE, Rusyn I, Zeisel S, Borchers CH. Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry. Metabolomics : Official Journal of the Metabolomic Society. 4: 128-140. PMID 19081807 DOI: 10.1007/s11306-008-0104-8  0.56
2008 Harrill AH, Rusyn I. Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity. Expert Opinion On Drug Metabolism & Toxicology. 4: 1379-89. PMID 18950280 DOI: 10.1517/17425255.4.11.1379  0.56
2008 Tsuchiya M, Kono H, Matsuda M, Fujii H, Rusyn I. Protective effect of Juzen-taiho-to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell-induced oxidative stress. International Journal of Cancer. Journal International Du Cancer. 123: 2503-11. PMID 18785209 DOI: 10.1002/ijc.23828  0.56
2008 Bradford BU, O'Connell TM, Han J, Kosyk O, Shymonyak S, Ross PK, Winnike J, Kono H, Rusyn I. Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease. Toxicology and Applied Pharmacology. 232: 236-43. PMID 18674555 DOI: 10.1016/j.taap.2008.06.022  0.56
2008 Pogribny IP, Tryndyak VP, Boureiko A, Melnyk S, Bagnyukova TV, Montgomery B, Rusyn I. Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. Mutation Research. 644: 17-23. PMID 18639561 DOI: 10.1016/j.mrfmmm.2008.06.009  0.56
2008 Zhu H, Rusyn I, Richard A, Tropsha A. Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity. Environmental Health Perspectives. 116: 506-13. PMID 18414635 DOI: 10.1289/ehp.10573  0.56
2008 Pogribny IP, Rusyn I, Beland FA. Epigenetic aspects of genotoxic and non-genotoxic hepatocarcinogenesis: studies in rodents. Environmental and Molecular Mutagenesis. 49: 9-15. PMID 17879298 DOI: 10.1002/em.20342  0.56
2008 Stotts D, Lee K, Rusyn I. Supporting computational systems science: Genomic analysis tool federations using aspects and AOP Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 4983: 457-468. DOI: 10.1007/978-3-540-79450-9_43  0.56
2007 Rusyn I, Fry RC, Begley TJ, Klapacz J, Svensson JP, Ambrose M, Samson LD. Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates. Plos One. 2: e1252. PMID 18043759 DOI: 10.1371/journal.pone.0001252  0.56
2007 Woods CG, Kosyk O, Bradford BU, Ross PK, Burns AM, Cunningham ML, Qu P, Ibrahim JG, Rusyn I. Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression. Toxicology and Applied Pharmacology. 225: 267-77. PMID 17950772 DOI: 10.1016/j.taap.2007.08.028  0.56
2007 Roberts A, McMillan L, Wang W, Parker J, Rusyn I, Threadgill D. Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows. Bioinformatics (Oxford, England). 23: i401-7. PMID 17646323 DOI: 10.1093/bioinformatics/btm220  0.56
2007 Pogribny IP, Tryndyak VP, Woods CG, Witt SE, Rusyn I. Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha. Mutation Research. 625: 62-71. PMID 17586532 DOI: 10.1016/j.mrfmmm.2007.05.004  0.56
2007 Yamashina S, Ikejima K, Rusyn I, Sato N. Glycine as a potent anti-angiogenic nutrient for tumor growth. Journal of Gastroenterology and Hepatology. 22: S62-4. PMID 17567469 DOI: 10.1111/j.1440-1746.2006.04655.x  0.56
2007 Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU, Cranson AB, Cunningham ML, Fannin RD, Higgins GM, Hurban P, ... ... Rusyn I, et al. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicological Sciences : An Official Journal of the Society of Toxicology. 99: 326-37. PMID 17562736 DOI: 10.1093/toxsci/kfm150  0.56
2007 Woods CG, Heuvel JP, Rusyn I. Genomic profiling in nuclear receptor-mediated toxicity. Toxicologic Pathology. 35: 474-94. PMID 17562482 DOI: 10.1080/01926230701311351  0.56
2007 Peffer RC, Moggs JG, Pastoor T, Currie RA, Wright J, Milburn G, Waechter F, Rusyn I. Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. Toxicological Sciences : An Official Journal of the Society of Toxicology. 99: 315-25. PMID 17557908 DOI: 10.1093/toxsci/kfm154  0.56
2007 Gatti D, Maki A, Chesler EJ, Kirova R, Kosyk O, Lu L, Manly KF, Williams RW, Perkins A, Langston MA, Threadgill DW, Rusyn I. Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology (Baltimore, Md.). 46: 548-57. PMID 17542012 DOI: 10.1002/hep.21682  0.56
2007 Woods CG, Burns AM, Bradford BU, Ross PK, Kosyk O, Swenberg JA, Cunningham ML, Rusyn I. WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. Toxicological Sciences : An Official Journal of the Society of Toxicology. 98: 366-74. PMID 17483499 DOI: 10.1093/toxsci/kfm104  0.56
2007 Hammond LE, Albright CD, He L, Rusyn I, Watkins SM, Doughman SD, Lemasters JJ, Coleman RA. Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. Experimental and Molecular Pathology. 82: 210-9. PMID 17258706 DOI: 10.1016/j.yexmp.2006.12.004  0.56
2007 Woods CG, Burns AM, Maki A, Bradford BU, Cunningham ML, Connor HD, Kadiiska MB, Mason RP, Peters JM, Rusyn I. Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase. Free Radical Biology & Medicine. 42: 335-42. PMID 17210446 DOI: 10.1016/j.freeradbiomed.2006.10.053  0.56
2007 Maki A, Kono H, Gupta M, Asakawa M, Suzuki T, Matsuda M, Fujii H, Rusyn I. Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Annals of Surgical Oncology. 14: 1182-90. PMID 17195915 DOI: 10.1245/s10434-006-9049-1  0.56
2007 Pogribny IP, Tryndyak VP, Muskhelishvili L, Rusyn I, Ross SA. Methyl deficiency, alterations in global histone modifications, and carcinogenesis. The Journal of Nutrition. 137: 216S-222S. PMID 17182829  0.56
2007 Roberts RA, Ganey PE, Ju C, Kamendulis LM, Rusyn I, Klaunig JE. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 96: 2-15. PMID 17122412 DOI: 10.1093/toxsci/kfl173  0.56
2006 Rusyn I, Peters JM, Cunningham ML. Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver. Critical Reviews in Toxicology. 36: 459-79. PMID 16954067 DOI: 10.1080/10408440600779065  0.56
2006 Kono H, Woods CG, Maki A, Connor HD, Mason RP, Rusyn I, Fujii H. Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. Free Radical Research. 40: 579-88. PMID 16753835 DOI: 10.1080/10715760600606374  0.56
2006 Powell CL, Kosyk O, Ross PK, Schoonhoven R, Boysen G, Swenberg JA, Heinloth AN, Boorman GA, Cunningham ML, Paules RS, Rusyn I. Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 93: 213-22. PMID 16751229 DOI: 10.1093/toxsci/kfl030  0.56
2005 Powell CL, Kosyk O, Bradford BU, Parker JS, Lobenhofer EK, Denda A, Uematsu F, Nakae D, Rusyn I. Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury. Hepatology (Baltimore, Md.). 42: 1137-47. PMID 16250055 DOI: 10.1002/hep.20910  0.56
2005 Powell CL, Swenberg JA, Rusyn I. Expression of base excision DNA repair genes as a biomarker of oxidative DNA damage. Cancer Letters. 229: 1-11. PMID 16157213 DOI: 10.1016/j.canlet.2004.12.002  0.56
2005 Uematsu F, Takahashi M, Yoshida M, Igarashi M, Watanabe N, Suzuki N, Abe M, Rusyn I, Floyd RA, Nakae D. Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non-cancerous, cirrhotic liver tissues in rats fed a choline-deficient, L-amino acid-defined diet. Cancer Science. 96: 414-24. PMID 16053513 DOI: 10.1111/j.1349-7006.2005.00069.x  0.56
2005 Rusyn I, Asakura S, Li Y, Kosyk O, Koc H, Nakamura J, Upton PB, Swenberg JA. Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver. Dna Repair. 4: 1099-110. PMID 16051529 DOI: 10.1016/j.dnarep.2005.05.009  0.56
2005 Bradford BU, Rusyn I. Swift increase in alcohol metabolism (SIAM): understanding the phenomenon of hypermetabolism in liver. Alcohol (Fayetteville, N.Y.). 35: 13-7. PMID 15922133 DOI: 10.1016/j.alcohol.2004.12.001  0.56
2005 Bammler T, Beyer RP, Bhattacharya S, Boorman GA, Boyles A, Bradford BU, Bumgarner RE, Bushel PR, Chaturvedi K, Choi D, Cunningham ML, Deng S, Dressman HK, Fannin RD, Farin FM, ... ... Rusyn I, et al. Standardizing global gene expression analysis between laboratories and across platforms. Nature Methods. 2: 351-6. PMID 15846362 DOI: 10.1038/nmeth754  0.56
2005 Bradford BU, Kono H, Isayama F, Kosyk O, Wheeler MD, Akiyama TE, Bleye L, Krausz KW, Gonzalez FJ, Koop DR, Rusyn I. Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver. Hepatology (Baltimore, Md.). 41: 336-44. PMID 15660387 DOI: 10.1002/hep.20532  0.56
2005 Hays T, Rusyn I, Burns AM, Kennett MJ, Ward JM, Gonzalez FJ, Peters JM. Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis. 26: 219-27. PMID 15447978 DOI: 10.1093/carcin/bgh285  0.56
2004 Qin LX, Kerr KF. Empirical evaluation of data transformations and ranking statistics for microarray analysis. Nucleic Acids Research. 32: 5471-9. PMID 15479783 DOI: 10.1093/nar/gkh866  0.56
2004 Rusyn I, Asakura S, Pachkowski B, Bradford BU, Denissenko MF, Peters JM, Holland SM, Reddy JK, Cunningham ML, Swenberg JA. Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators. Cancer Research. 64: 1050-7. PMID 14871837 DOI: 10.1158/0008-5472.CAN-03-3027  0.56
2003 Wheeler MD, Smutney OM, Check JF, Rusyn I, Schulte-Hermann R, Thurman RG. Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomy. American Journal of Physiology. Gastrointestinal and Liver Physiology. 284: G302-12. PMID 12388208 DOI: 10.1152/ajpgi.00175.2002  0.56
2002 Kono H, Fujii H, Asakawa M, Yamamoto M, Maki A, Matsuda M, Rusyn I, Matsumoto Y. Functional heterogeneity of the kupffer cell population is involved in the mechanism of gadolinium chloride in rats administered endotoxin. The Journal of Surgical Research. 106: 179-87. PMID 12127824 DOI: 10.1006/jsre.2002.6434  0.56
2002 Yin M, Zhong Z, Connor HD, Bunzendahl H, Finn WF, Rusyn I, Li X, Raleigh JA, Mason RP, Thurman RG. Protective effect of glycine on renal injury induced by ischemia-reperfusion in vivo. American Journal of Physiology. Renal Physiology. 282: F417-23. PMID 11832421 DOI: 10.1152/ajprenal.00011.2001  0.56
2001 Yamashina S, Konno A, Wheeler MD, Rusyn I, Rusyn EV, Cox AD, Thurman RG. Endothelial cells contain a glycine-gated chloride channel Nutrition and Cancer. 40: 197-204. PMID 11962256  0.56
2001 Rusyn I. In memoriam: Ronald G.Thurman (1941-2001) Carcinogenesis. 22: 1899-1901. PMID 11751420  0.56
2001 Wheeler MD, Kono H, Yin M, Nakagami M, Uesugi T, Arteel GE, Gäbele E, Rusyn I, Yamashina S, Froh M, Adachi Y, Iimuro Y, Bradford BU, Smutney OM, Connor HD, et al. The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radical Biology & Medicine. 31: 1544-9. PMID 11744328 DOI: 10.1016/S0891-5849(01)00748-1  0.56
2001 Yin M, Gäbele E, Wheeler MD, Connor H, Bradford BU, Dikalova A, Rusyn I, Mason R, Thurman RG. Alcohol-induced free radicals in mice: Direct toxicants or signaling molecules? Hepatology. 34: 935-942. PMID 11679964 DOI: 10.1053/jhep.2001.28888  0.56
2001 Xu S, Zhu BT, Turan V, Rusyn I, Thurman R, Peters JM, Gonzalez FJ, Conney AH. PPARα-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator Endocrinology. 142: 3554-3557. PMID 11459802 DOI: 10.1210/en.142.8.3554  0.56
2001 Kono H, Uesugi T, Froh M, Rusyn I, Bradford BU, Thurman RG. ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 280: G1289-95. PMID 11352823  0.56
2001 Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B, Brenner DA, Mason RP, Arteel GE, Thurman RG. Development of an animal model of chronic alcohol-induced pancreatitis in the rat American Journal of Physiology - Gastrointestinal and Liver Physiology. 280. PMID 11352811  0.56
2001 Wheeler MD, Yamashina S, Froh M, Rusyn I, Thurman RG. Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF-kappaB activation and cytokine production. Journal of Leukocyte Biology. 69: 622-30. PMID 11310849  0.56
2001 Kono H, Rusyn I, Uesugi T, Yamashina S, Connor HD, Dikalova A, Mason RP, Thurman RG. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat American Journal of Physiology - Gastrointestinal and Liver Physiology. 280. PMID 11292610  0.56
2001 Wheeler MD, Kono H, Yin M, Rusyn I, Froh M, Connor HD, Mason RP, Samulski RJ, Thurman RG. Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats. Gastroenterology. 120: 1241-50. PMID 11266387 DOI: 10.1053/gast.2001.23253  0.56
2001 Rusyn I, Kadiiska MB, Dikalova A, Kono H, Yin M, Tsuchiya K, Mason RP, Peters JM, Gonzalez FJ, Segal BH, Holland SM, Thurman RG. Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells. Molecular Pharmacology. 59: 744-50. PMID 11259618  0.56
2001 Kono H, Arteel GE, Rusyn I, Sies H, Thurman RG. Ebselen prevents early alcohol-induced liver injury in rats. Free Radical Biology & Medicine. 30: 403-11. PMID 11182296 DOI: 10.1016/S0891-5849(00)00490-1  0.56
2000 Rusyn I, Rose ML, Bojes HK, Thurman RG. Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators Antioxidants and Redox Signaling. 2: 607-621. PMID 11229371  0.56
2000 Kono H, Bradford BU, Rusyn I, Fujii H, Matsumoto Y, Yin M, Thurman RG. Development of an intragastric enteral model in the mouse: Studies of alcohol-induced liver disease using knockout technology Journal of Hepato-Biliary-Pancreatic Surgery. 7: 395-400. PMID 11180860  0.56
2000 Rusyn I, Denissenko MF, Wong VA, Butterworth BE, Cunningham ML, Upton PB, Thurman RG, Swenberg JA. Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency. Carcinogenesis. 21: 2141-5. PMID 11133801  0.56
2000 Yamashina S, Wheeler MD, Rusyn I, Ikejima K, Sato N, Thurman RG. Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor-associated kinase Biochemical and Biophysical Research Communications. 277: 686-690. PMID 11062014 DOI: 10.1006/bbrc.2000.3738  0.56
2000 Wheeler MD, Kono H, Rusyn I, Arteel GE, McCarty D, Jude Samulski R, Thurman RG. Chronic ethanol increases adeno-associated viral transgene expression in rat liver via oxidant and NFκB-dependent mechanisms Hepatology. 32: 1050-1059. PMID 11050056  0.56
2000 Kono H, Rusyn I, Yin M, Gäbele E, Yamashina S, Dikalova A, Kadiiska MB, Connor HD, Mason RP, Segal BH, Bradford BU, Holland SM, Thurman RG. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. The Journal of Clinical Investigation. 106: 867-72. PMID 11018074 DOI: 10.1172/JCI9020  0.56
2000 Rusyn I, Yamashina S, Segal BH, Schoonhoven R, Holland SM, Cattley RC, Swenberg JA, Thurman RG. Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators. Cancer Research. 60: 4798-803. PMID 10987289  0.56
2000 Kono H, Wheeler MD, Rusyn I, Lin M, Seabra V, Rivera CA, Bradford BU, Forman DT, Thurman RG. Gender differences in early alcohol-induced liver injury: Role of CD14, NF-κB, and TNF-α American Journal of Physiology - Gastrointestinal and Liver Physiology. 278. PMID 10762620  0.56
2000 Yin M, Rusyn I, Schoonhoven R, Graves LM, Rusyn EV, Li X, Li F, Cox AD, Harding TW, Bunzendahl H, Swenberg JA, Thurman RG. Inhibition of chronic rejection of aortic allografts by dietary glycine. Transplantation. 69: 773-80. PMID 10755525  0.56
2000 Peters JM, Rusyn I, Rose ML, Gonzalez FJ, Thurman RG. Peroxisome proliferator-activated receptor α is restricted to hepatic parenchymal cells, not Kupffer cells: Implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis Carcinogenesis. 21: 823-826. PMID 10753222  0.56
2000 Kono H, Rusyn I, Bradford BU, Connor HD, Mason RP, Thurman RG. Allopurinol prevents early alcohol-induced liver injury in rats Journal of Pharmacology and Experimental Therapeutics. 293: 296-303. PMID 10734182  0.56
2000 Rose ML, Rusyn I, Bojes HK, Belyea J, Cattley RC, Thurman RG. Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 448: 179-192. PMID 10725471 DOI: 10.1016/S0027-5107(99)00235-3  0.56
2000 Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D, Brenner D, Thurman RG. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat Hepatology. 31: 391-398. PMID 10655262  0.56
1999 Wheeler MD, Ikejema K, Enomoto N, Stacklewitz RF, Seabra V, Zhong Z, Yin M, Schemmer P, Rose ML, Rusyn I, Bradford B, Thurman RG. Glycine: A new anti-inflammatory immunonutrient Cellular and Molecular Life Sciences. 56: 843-856. PMID 11212343  0.56
1999 Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA, Brenner DA, Thurman RG. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Carcinogenesis. 20: 2095-100. PMID 10545411 DOI: 10.1093/carcin/20.11.2095  0.56
1999 Arteel GE, Kadiiska MB, Rusyn I, Bradford BU, Mason RP, Raleigh JA, Thurman RG. Oxidative stress occurs in perfused rat liver at low oxygen tension by mechanisms involving peroxynitrite Molecular Pharmacology. 55: 708-715. PMID 10101029  0.56
1999 Rose ML, Rusyn I, Bojes HK, Germolec DR, Luster M, Thurman RG. Role of kupffer cells in peroxisome proliferator-induced hepatocyte proliferation Drug Metabolism Reviews. 31: 87-116. PMID 10065367 DOI: 10.1081/DMR-100101909  0.56
1999 Stachlewitz RF, Seabra V, Bradford B, Bradham CA, Rusyn I, Germolec D, Thurman RG. Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: Role of Kupffer cells Hepatology. 29: 737-745. PMID 10051475  0.56
1998 Yin M, Ikejima K, Arteel GE, Seabra V, Bradford BU, Kono H, Rusyn I, Thurman RG. Glycine accelerates recovery from alcohol-induced liver injury Journal of Pharmacology and Experimental Therapeutics. 286: 1014-1019. PMID 9694963  0.56
1998 Rusyn I, Tsukamoto H, Thurman RG. WY-14 643 rapidly activates nuclear factor κB in Kupffer cells before hepatocytes Carcinogenesis. 19: 1217-1222. PMID 9683180 DOI: 10.1093/carcin/19.7.1217  0.56
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